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Conserved domains on  [gi|268638318|ref|XP_002649211|]
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PA14 domain-containing protein [Dictyostelium discoideum AX4]

Protein Classification

similar to PA14 domain-containing protein( domain architecture ID 10020266)

protein similar to PA14 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Fibro_Slime TIGR02148
fibro-slime domain; This model represents a conserved region of about 90 amino acids, shared ...
 153-241 4.28e-45

fibro-slime domain; This model represents a conserved region of about 90 amino acids, shared in at least 4 distinct large putative proteins from the slime mold Dictyostelium discoideum and 10 proteins from the rumen bacterium Fibrobacter succinogenes, and in no other species so far. We propose here the name fibro-slime domain


:

Pssm-ID: 162730  Cd Length: 90  Bit Score: 152.86  E-value: 4.28e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268638318  153 YHNYHFCMKMNTVFTYKGYEVFNFRGDDDVWVFINNKLVIDLGGLHSPIGTSVDTMTLGLTIGNSYNFDLFFCERHTVGS 232
Cdd:TIGR02148   1 YHNFHFCMKINAQFKYVGGQYFEFRGDDDVWVFINNKLVVDIGGQHPAVPGAVDLDTLGLKEGKTYPFDIFYCERHTTGS 80


                  ....*....
gi 268638318  233 TIKIETNLL 241
Cdd:TIGR02148  81 NFRIRTSIQ 89
 
Name Accession Description Interval E-value
Fibro_Slime TIGR02148
fibro-slime domain; This model represents a conserved region of about 90 amino acids, shared ...
 153-241 4.28e-45

fibro-slime domain; This model represents a conserved region of about 90 amino acids, shared in at least 4 distinct large putative proteins from the slime mold Dictyostelium discoideum and 10 proteins from the rumen bacterium Fibrobacter succinogenes, and in no other species so far. We propose here the name fibro-slime domain


Pssm-ID: 162730  Cd Length: 90  Bit Score: 152.86  E-value: 4.28e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268638318  153 YHNYHFCMKMNTVFTYKGYEVFNFRGDDDVWVFINNKLVIDLGGLHSPIGTSVDTMTLGLTIGNSYNFDLFFCERHTVGS 232
Cdd:TIGR02148   1 YHNFHFCMKINAQFKYVGGQYFEFRGDDDVWVFINNKLVVDIGGQHPAVPGAVDLDTLGLKEGKTYPFDIFYCERHTTGS 80


                  ....*....
gi 268638318  233 TIKIETNLL 241
Cdd:TIGR02148  81 NFRIRTSIQ 89
PA14 pfam07691
PA14 domain; This domain forms an insert in bacterial beta-glucosidases and is found in other ...
 122-256 2.31e-17

PA14 domain; This domain forms an insert in bacterial beta-glucosidases and is found in other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins, including anthrax protective antigen (PA). The domain also occurs in a Dictyostelium prespore-cell-inducing factor Psi and in fibrocystin, the mammalian protein whose mutation leads to polycystic kidney and hepatic disease. The crystal structure of PA shows that this domain (named PA14 after its location in the PA20 pro-peptide) has a beta-barrel structure. The PA14 domain sequence suggests a binding function, rather than a catalytic role. The PA14 domain distribution is compatible with carbohydrate binding.


Pssm-ID: 400161 [Multi-domain]  Cd Length: 141  Bit Score: 78.56  E-value: 2.31e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268638318  122 YVYDNQNFFPIDNQGFDVDPAKRIY-LNEK--KTYHNYHFCMKMNTVFTYK--GYEVFNFRGDDDVWVFINNKLVIDLGG 196
Cdd:pfam07691   7 GIYFNDADFSGDPVLIDTDPDNTFYwDTDVpgFGEAPGDFSARWTGYLLPPesGTYTFGVASDDGARLWIDGELVIDNWG 86

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 268638318  197 LHSPIGTSVDTMTLGLTIGNSYNFDLFFCERHTVGSTIkietnLLFYCPFKDYCGVCQGD 256
Cdd:pfam07691  87 QHPPDASPEESNTLYLVAGKLYPIRIEYFHAGTGGSVQ-----LSWTSPDGGGEEIDEDG 141
PA14 smart00758
domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, ...
 122-254 2.74e-14

domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins;


Pssm-ID: 214807 [Multi-domain]  Cd Length: 136  Bit Score: 69.74  E-value: 2.74e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268638318   122 YVYDNQNFFPIDNQGFDVDPAKRIY-----LNEKKTYHNYHFCM----KMNTvftyKGYEVFNFRGDDDVWVFINNKLVI 192
Cdd:smart00758   5 GYYFENEKFSGLPEIIDTDPLNTFYwdsdkFGEGEKADNFSVRWtgylKPPE----DGEYTFSITSDDGARLWIDGKLVI 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 268638318   193 DLGGLHSpiGTSVDTMTLGLTIGNSYNFDLFFCERHTVGStikieTNLLFYCPFKDYCGVCQ 254
Cdd:smart00758  81 DNWGKHE--ARPSTSSTLYLLAGGTYPIRIEYFEAGTGGL-----LKLGWTTPDAAKEAIDD 135
 
Name Accession Description Interval E-value
Fibro_Slime TIGR02148
fibro-slime domain; This model represents a conserved region of about 90 amino acids, shared ...
 153-241 4.28e-45

fibro-slime domain; This model represents a conserved region of about 90 amino acids, shared in at least 4 distinct large putative proteins from the slime mold Dictyostelium discoideum and 10 proteins from the rumen bacterium Fibrobacter succinogenes, and in no other species so far. We propose here the name fibro-slime domain


Pssm-ID: 162730  Cd Length: 90  Bit Score: 152.86  E-value: 4.28e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268638318  153 YHNYHFCMKMNTVFTYKGYEVFNFRGDDDVWVFINNKLVIDLGGLHSPIGTSVDTMTLGLTIGNSYNFDLFFCERHTVGS 232
Cdd:TIGR02148   1 YHNFHFCMKINAQFKYVGGQYFEFRGDDDVWVFINNKLVVDIGGQHPAVPGAVDLDTLGLKEGKTYPFDIFYCERHTTGS 80


                  ....*....
gi 268638318  233 TIKIETNLL 241
Cdd:TIGR02148  81 NFRIRTSIQ 89
PA14 pfam07691
PA14 domain; This domain forms an insert in bacterial beta-glucosidases and is found in other ...
 122-256 2.31e-17

PA14 domain; This domain forms an insert in bacterial beta-glucosidases and is found in other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins, including anthrax protective antigen (PA). The domain also occurs in a Dictyostelium prespore-cell-inducing factor Psi and in fibrocystin, the mammalian protein whose mutation leads to polycystic kidney and hepatic disease. The crystal structure of PA shows that this domain (named PA14 after its location in the PA20 pro-peptide) has a beta-barrel structure. The PA14 domain sequence suggests a binding function, rather than a catalytic role. The PA14 domain distribution is compatible with carbohydrate binding.


Pssm-ID: 400161 [Multi-domain]  Cd Length: 141  Bit Score: 78.56  E-value: 2.31e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268638318  122 YVYDNQNFFPIDNQGFDVDPAKRIY-LNEK--KTYHNYHFCMKMNTVFTYK--GYEVFNFRGDDDVWVFINNKLVIDLGG 196
Cdd:pfam07691   7 GIYFNDADFSGDPVLIDTDPDNTFYwDTDVpgFGEAPGDFSARWTGYLLPPesGTYTFGVASDDGARLWIDGELVIDNWG 86

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 268638318  197 LHSPIGTSVDTMTLGLTIGNSYNFDLFFCERHTVGSTIkietnLLFYCPFKDYCGVCQGD 256
Cdd:pfam07691  87 QHPPDASPEESNTLYLVAGKLYPIRIEYFHAGTGGSVQ-----LSWTSPDGGGEEIDEDG 141
PA14 smart00758
domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, ...
 122-254 2.74e-14

domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins;


Pssm-ID: 214807 [Multi-domain]  Cd Length: 136  Bit Score: 69.74  E-value: 2.74e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 268638318   122 YVYDNQNFFPIDNQGFDVDPAKRIY-----LNEKKTYHNYHFCM----KMNTvftyKGYEVFNFRGDDDVWVFINNKLVI 192
Cdd:smart00758   5 GYYFENEKFSGLPEIIDTDPLNTFYwdsdkFGEGEKADNFSVRWtgylKPPE----DGEYTFSITSDDGARLWIDGKLVI 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 268638318   193 DLGGLHSpiGTSVDTMTLGLTIGNSYNFDLFFCERHTVGStikieTNLLFYCPFKDYCGVCQ 254
Cdd:smart00758  81 DNWGKHE--ARPSTSSTLYLLAGGTYPIRIEYFEAGTGGL-----LKLGWTTPDAAKEAIDD 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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