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Conserved domains on  [gi|805752177|ref|XP_003699222|]
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PREDICTED: pyruvate kinase-like isoform X1 [Megachile rotundata]

Protein Classification

pyruvate kinase( domain architecture ID 1562468)

pyruvate kinase catalyzes the phosphorylation of pyruvate to form phosphoenolpyruvate and functions in regulating glycolysis

CATH:  2.40.33.10|3.20.20.60|3.40.1380.20
EC:  2.7.1.40
Gene Ontology:  GO:0004743|GO:0006096|GO:0005524|GO:0030955|GO:0000287
PubMed:  31342570
SCOP:  4003255|4002474|4000500

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pyruvate_Kinase super family cl39076
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 60-546 1.46e-117

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


The actual alignment was detected with superfamily member cd00288:

Pssm-ID: 453956 [Multi-domain]  Cd Length: 480  Bit Score: 356.62  E-value: 1.46e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177  60 ARLTKLMVTLGNANSHPEAIVEMMMAGANIVRLNMSHEQEKWHAITVQSIREAgnrMYEYTSdiyPLGVAMNLRGPEIRT 139
Cdd:cd00288    1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREA---AEKTGG---PVAIALDTKGPEIRT 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 140 GIFNGDPlnrgYAQLKEGGIVRlVTNDLAKRAGSACCFWISYPNLPRVCRPGDKILIDRGAAILQVR-CVRETSLVCKVI 218
Cdd:cd00288   75 GLFKGGK----DISLKAGDKFL-VTTDPAAKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLsKDDDKTLVCEVL 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 219 KGGIIKDEKLVQLMDSIIPLPQISETDNEHIRLAADLECDILIANHVRNKRLINGIKSRLKQIGANkVCVMAKISSQQGL 298
Cdd:cd00288  150 NGGVLGSRKGVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKD-IKIIAKIENQEGV 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 299 ENFDEILGAADAILLDRKSVEIDVGPEKMFLVEKVVIGKCMNVGKPV-----MLAFHVPNCGQPRIDMNLIANAVLTGTD 373
Cdd:cd00288  229 NNFDEILEASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVitatqMLESMIYNPRPTRAEVSDVANAVLDGTD 308

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 374 GIFLKTGTLNCKQTSELLKNIDVICREAESARWQREIFNDLSHKIAIPLDPSQAIIVGAIETCSKSNAAAIIVTTTSGRT 453
Cdd:cd00288  309 CVMLSGETAKGKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRT 388

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 454 ATMLSLYRPRCPIVAITRYGIVARSLQLYHGLYPLHYINPPLcDWSKDMETRIESGVNFLRRKKYIKVGDAIIIVSGWRQ 533
Cdd:cd00288  389 ARLVSKYRPNAPIIAVTRNEQTARQLHLYRGVYPVLFEEPKP-GWQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPV 467

                        490
                 ....*....|...
gi 805752177 534 GIGFTNCIRIIYV 546
Cdd:cd00288  468 GSGSTNTMRILTV 480
 
Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 60-546 1.46e-117

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 356.62  E-value: 1.46e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177  60 ARLTKLMVTLGNANSHPEAIVEMMMAGANIVRLNMSHEQEKWHAITVQSIREAgnrMYEYTSdiyPLGVAMNLRGPEIRT 139
Cdd:cd00288    1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREA---AEKTGG---PVAIALDTKGPEIRT 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 140 GIFNGDPlnrgYAQLKEGGIVRlVTNDLAKRAGSACCFWISYPNLPRVCRPGDKILIDRGAAILQVR-CVRETSLVCKVI 218
Cdd:cd00288   75 GLFKGGK----DISLKAGDKFL-VTTDPAAKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLsKDDDKTLVCEVL 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 219 KGGIIKDEKLVQLMDSIIPLPQISETDNEHIRLAADLECDILIANHVRNKRLINGIKSRLKQIGANkVCVMAKISSQQGL 298
Cdd:cd00288  150 NGGVLGSRKGVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKD-IKIIAKIENQEGV 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 299 ENFDEILGAADAILLDRKSVEIDVGPEKMFLVEKVVIGKCMNVGKPV-----MLAFHVPNCGQPRIDMNLIANAVLTGTD 373
Cdd:cd00288  229 NNFDEILEASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVitatqMLESMIYNPRPTRAEVSDVANAVLDGTD 308

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 374 GIFLKTGTLNCKQTSELLKNIDVICREAESARWQREIFNDLSHKIAIPLDPSQAIIVGAIETCSKSNAAAIIVTTTSGRT 453
Cdd:cd00288  309 CVMLSGETAKGKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRT 388

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 454 ATMLSLYRPRCPIVAITRYGIVARSLQLYHGLYPLHYINPPLcDWSKDMETRIESGVNFLRRKKYIKVGDAIIIVSGWRQ 533
Cdd:cd00288  389 ARLVSKYRPNAPIIAVTRNEQTARQLHLYRGVYPVLFEEPKP-GWQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPV 467

                        490
                 ....*....|...
gi 805752177 534 GIGFTNCIRIIYV 546
Cdd:cd00288  468 GSGSTNTMRILTV 480
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 61-546 1.37e-96

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 301.95  E-value: 1.37e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177  61 RLTKLMVTLGNANSHPEAIVEMMMAGANIVRLNMSHEQEKWHAITVQSIREAGNRMYeytsdiYPLGVAMNLRGPEIRTG 140
Cdd:COG0469    3 RRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELG------RPVAILLDLQGPKIRTG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 141 IFNGDPLnrgyaQLKEGGIVRLVTNDLAkraGSACCFWISYPNLPRVCRPGDKILIDRGAAILQVRCVRETSLVCKVIKG 220
Cdd:COG0469   77 KFKEGPV-----ELKKGDTFTLTTDDVE---GDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNG 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 221 GIIKDEKLVQLMDSIIPLPQISETDNEHIRLAADLECDILIANHVRNKRLINGIKSRLKQIGANkVCVMAKISSQQGLEN 300
Cdd:COG0469  149 GVLSSRKGVNLPGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGR-APIIAKIEKPEAVEN 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 301 FDEILGAADAIL-----LdrkSVEIdvGPEKMFLVEKVVIGKCMNVGKPVMLAfhvpncGQ--------PR------IDm 361
Cdd:COG0469  228 LDEIIEASDGIMvargdL---GVEI--PLEEVPLIQKRIIRKARRAGKPVITA------TQmlesmienPRptraevSD- 295

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 362 nlIANAVLTGTDGIFLkTGtlnckQTS------ELLKNIDVICREAESARWQREIFNDLSHKiaIPLDPSQAIIVGAIET 435
Cdd:COG0469  296 --VANAVLDGTDAVML-SG-----ETAvgkypvEAVETMARIAEEAEKSLDYRRILDRLRDE--PERTITDAIARAAVEL 365

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 436 CSKSNAAAIIVTTTSGRTATMLSLYRPRCPIVAITRYGIVARSLQLYHGLYPLHYinpplcDWSKDMETRIESGVNFLRR 515
Cdd:COG0469  366 AEDLGAKAIVAFTESGSTARRISRYRPKVPILALTPNERTARRLALVWGVYPVLV------DDVESTDEMIEEAVEALLE 439

                        490       500       510
                 ....*....|....*....|....*....|..
gi 805752177 516 KKYIKVGDAIIIVSGWRQGI-GFTNCIRIIYV 546
Cdd:COG0469  440 EGLVKPGDLVVITAGVPVGVpGTTNTLKVHRV 471
PRK05826 PRK05826
pyruvate kinase; Provisional
 61-530 1.15e-76

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 250.07  E-value: 1.15e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177  61 RLTKLMVTLGNANSHPEAIVEMMMAGANIVRLNMSHEQEKWHAITVQSIREAGNRMYEytsdiyPLGVAMNLRGPEIRTG 140
Cdd:PRK05826   4 RRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLGR------PVAILLDLKGPKIRVG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 141 IFNGDPLnrgyaQLKEGGIVRLVTNDlaKRAGSACCFWISYPNLPRVCRPGDKILIDRGAAILQVRCVRETSLVCKVIKG 220
Cdd:PRK05826  78 KFKEGKI-----TLKTGDKFTLDTDQ--KEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNG 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 221 GIIKDEKLVQLMDSIIPLPQISETDNEHIRLAADLECDILIANHVRNKRLINGIKSRLKQIGANKVCVMAKISSQQGLEN 300
Cdd:PRK05826 151 GPLSNNKGINIPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCPHAKIIAKIERAEAVDN 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 301 FDEILGAADAILLDRKSVEIDVGPEKMFLVEKVVIGKCMNVGKPV-----MLAFHVPNcgqPR------IDmnlIANAVL 369
Cdd:PRK05826 231 IDEIIEASDGIMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVitatqMLESMIEN---PRptraevSD---VANAVL 304

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 370 TGTDGIFLKTGTLNCKQTSELLKNIDVICREAESARWQREIFNDLSHKIAiplDPSQAIIVGAIET-CSKSNAAAIIVTT 448
Cdd:PRK05826 305 DGTDAVMLSGETAAGKYPVEAVEAMARICKGAEKEFSINLSKHRLDRQFD---RIDEAIAMSAMYAaNHLKGVKAIVALT 381

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 449 TSGRTATMLSLYRPRCPIVAITRYGIVARSLQLYHGLYPLHyinpplCDWSKDMETRIESGVNFLRRKKYIKVGDAIIIV 528
Cdd:PRK05826 382 ESGRTARLISRFRPGAPIFAVTRDEKTQRRLALYRGVYPVL------FDSAADTDDAAEEALRLLLEKGLVESGDLVVVT 455


                 ..
gi 805752177 529 SG 530
Cdd:PRK05826 456 SG 457
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 60-411 2.83e-65

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 216.47  E-value: 2.83e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177   60 ARLTKLMVTLGNANSHPEAIVEMMMAGANIVRLNMSHEQEKWHAITVQSIREAgnrmyeytSDIYP--LGVAMNLRGPEI 137
Cdd:pfam00224   1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREA--------EEKTGgtVAIALDTKGPEI 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177  138 RTGIFNGDPLNrgyAQLKEGGIVRLVTNDLAKRAGSACCFWISYPNLPRVCRPGDKILIDRGAAILQVR-CVRETSLVCK 216
Cdd:pfam00224  73 RTGNTKDGKKD---IELKAGDEMIVSTDAKYKGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLsKDDDKTLVVE 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177  217 VIKGGIIKDEKLVQLMDSIIPLPQISETDNEHIRLAADLECDILIANHVRNKRLINGIKSRLKQIGANkVCVMAKISSQQ 296
Cdd:pfam00224 150 VLNGGVIGSRKGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKN-IQIIAKIENQE 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177  297 GLENFDEILGAADAILLDRKSVEIDVGPEKMFLVEKVVIGKCMNVGKPV-----MLAFHVPNCGQPRIDMNLIANAVLTG 371
Cdd:pfam00224 229 GVNNFDEILEATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVitatqMLESMIYNPRPTRAEVSDVANAVLDG 308

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 805752177  372 TDGIFLKTGTLNCKQTSELLKNIDVICREAESARWQREIF 411
Cdd:pfam00224 309 TDCVMLSGETAKGNYPVEAVRMMHEICLEAEKALPHRNLF 348
 
Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 60-546 1.46e-117

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 356.62  E-value: 1.46e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177  60 ARLTKLMVTLGNANSHPEAIVEMMMAGANIVRLNMSHEQEKWHAITVQSIREAgnrMYEYTSdiyPLGVAMNLRGPEIRT 139
Cdd:cd00288    1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREA---AEKTGG---PVAIALDTKGPEIRT 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 140 GIFNGDPlnrgYAQLKEGGIVRlVTNDLAKRAGSACCFWISYPNLPRVCRPGDKILIDRGAAILQVR-CVRETSLVCKVI 218
Cdd:cd00288   75 GLFKGGK----DISLKAGDKFL-VTTDPAAKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLsKDDDKTLVCEVL 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 219 KGGIIKDEKLVQLMDSIIPLPQISETDNEHIRLAADLECDILIANHVRNKRLINGIKSRLKQIGANkVCVMAKISSQQGL 298
Cdd:cd00288  150 NGGVLGSRKGVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKD-IKIIAKIENQEGV 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 299 ENFDEILGAADAILLDRKSVEIDVGPEKMFLVEKVVIGKCMNVGKPV-----MLAFHVPNCGQPRIDMNLIANAVLTGTD 373
Cdd:cd00288  229 NNFDEILEASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVitatqMLESMIYNPRPTRAEVSDVANAVLDGTD 308

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 374 GIFLKTGTLNCKQTSELLKNIDVICREAESARWQREIFNDLSHKIAIPLDPSQAIIVGAIETCSKSNAAAIIVTTTSGRT 453
Cdd:cd00288  309 CVMLSGETAKGKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRT 388

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 454 ATMLSLYRPRCPIVAITRYGIVARSLQLYHGLYPLHYINPPLcDWSKDMETRIESGVNFLRRKKYIKVGDAIIIVSGWRQ 533
Cdd:cd00288  389 ARLVSKYRPNAPIIAVTRNEQTARQLHLYRGVYPVLFEEPKP-GWQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPV 467

                        490
                 ....*....|...
gi 805752177 534 GIGFTNCIRIIYV 546
Cdd:cd00288  468 GSGSTNTMRILTV 480
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 61-546 1.37e-96

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 301.95  E-value: 1.37e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177  61 RLTKLMVTLGNANSHPEAIVEMMMAGANIVRLNMSHEQEKWHAITVQSIREAGNRMYeytsdiYPLGVAMNLRGPEIRTG 140
Cdd:COG0469    3 RRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELG------RPVAILLDLQGPKIRTG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 141 IFNGDPLnrgyaQLKEGGIVRLVTNDLAkraGSACCFWISYPNLPRVCRPGDKILIDRGAAILQVRCVRETSLVCKVIKG 220
Cdd:COG0469   77 KFKEGPV-----ELKKGDTFTLTTDDVE---GDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNG 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 221 GIIKDEKLVQLMDSIIPLPQISETDNEHIRLAADLECDILIANHVRNKRLINGIKSRLKQIGANkVCVMAKISSQQGLEN 300
Cdd:COG0469  149 GVLSSRKGVNLPGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGR-APIIAKIEKPEAVEN 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 301 FDEILGAADAIL-----LdrkSVEIdvGPEKMFLVEKVVIGKCMNVGKPVMLAfhvpncGQ--------PR------IDm 361
Cdd:COG0469  228 LDEIIEASDGIMvargdL---GVEI--PLEEVPLIQKRIIRKARRAGKPVITA------TQmlesmienPRptraevSD- 295

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 362 nlIANAVLTGTDGIFLkTGtlnckQTS------ELLKNIDVICREAESARWQREIFNDLSHKiaIPLDPSQAIIVGAIET 435
Cdd:COG0469  296 --VANAVLDGTDAVML-SG-----ETAvgkypvEAVETMARIAEEAEKSLDYRRILDRLRDE--PERTITDAIARAAVEL 365

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 436 CSKSNAAAIIVTTTSGRTATMLSLYRPRCPIVAITRYGIVARSLQLYHGLYPLHYinpplcDWSKDMETRIESGVNFLRR 515
Cdd:COG0469  366 AEDLGAKAIVAFTESGSTARRISRYRPKVPILALTPNERTARRLALVWGVYPVLV------DDVESTDEMIEEAVEALLE 439

                        490       500       510
                 ....*....|....*....|....*....|..
gi 805752177 516 KKYIKVGDAIIIVSGWRQGI-GFTNCIRIIYV 546
Cdd:COG0469  440 EGLVKPGDLVVITAGVPVGVpGTTNTLKVHRV 471
PRK05826 PRK05826
pyruvate kinase; Provisional
 61-530 1.15e-76

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 250.07  E-value: 1.15e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177  61 RLTKLMVTLGNANSHPEAIVEMMMAGANIVRLNMSHEQEKWHAITVQSIREAGNRMYEytsdiyPLGVAMNLRGPEIRTG 140
Cdd:PRK05826   4 RRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLGR------PVAILLDLKGPKIRVG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 141 IFNGDPLnrgyaQLKEGGIVRLVTNDlaKRAGSACCFWISYPNLPRVCRPGDKILIDRGAAILQVRCVRETSLVCKVIKG 220
Cdd:PRK05826  78 KFKEGKI-----TLKTGDKFTLDTDQ--KEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNG 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 221 GIIKDEKLVQLMDSIIPLPQISETDNEHIRLAADLECDILIANHVRNKRLINGIKSRLKQIGANKVCVMAKISSQQGLEN 300
Cdd:PRK05826 151 GPLSNNKGINIPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCPHAKIIAKIERAEAVDN 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 301 FDEILGAADAILLDRKSVEIDVGPEKMFLVEKVVIGKCMNVGKPV-----MLAFHVPNcgqPR------IDmnlIANAVL 369
Cdd:PRK05826 231 IDEIIEASDGIMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVitatqMLESMIEN---PRptraevSD---VANAVL 304

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 370 TGTDGIFLKTGTLNCKQTSELLKNIDVICREAESARWQREIFNDLSHKIAiplDPSQAIIVGAIET-CSKSNAAAIIVTT 448
Cdd:PRK05826 305 DGTDAVMLSGETAAGKYPVEAVEAMARICKGAEKEFSINLSKHRLDRQFD---RIDEAIAMSAMYAaNHLKGVKAIVALT 381

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 449 TSGRTATMLSLYRPRCPIVAITRYGIVARSLQLYHGLYPLHyinpplCDWSKDMETRIESGVNFLRRKKYIKVGDAIIIV 528
Cdd:PRK05826 382 ESGRTARLISRFRPGAPIFAVTRDEKTQRRLALYRGVYPVL------FDSAADTDDAAEEALRLLLEKGLVESGDLVVVT 455


                 ..
gi 805752177 529 SG 530
Cdd:PRK05826 456 SG 457
PTZ00300 PTZ00300
pyruvate kinase; Provisional
 88-546 9.45e-76

pyruvate kinase; Provisional


Pssm-ID: 140321 [Multi-domain]  Cd Length: 454  Bit Score: 247.27  E-value: 9.45e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177  88 NIVRLNMSHEQEKWHAITVQSIREAGNrmyEYTSDIyplGVAMNLRGPEIRTGIFNGdplnrGYAQLKEGGIVRLVTNDL 167
Cdd:PTZ00300   2 SVARMNFSHGSHEYHQTTINNVRQAAA---ELGVNI---AIALDTKGPEIRTGLFVG-----GEAVMERGATCYVTTDPA 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 168 AKRAGSACCFWISYPNLPRVCRPGDKILIDRGAAILQVRCVR-ETSLVCKVIKGGIIKDEKLVQLMDSIIPLPQISETDN 246
Cdd:PTZ00300  71 FADKGTKDKFYIDYQNLSKVVRPGGYIYIDDGILILHVQSHEdEQTLKCTVTNAHTISDRRGVNLPGCDVDLPAVSAKDC 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 247 EHIRLAADLECDILIANHVRNKRLINGIKSRLKQIGANkVCVMAKISSQQGLENFDEILGAADAILLDRKSVEIDVGPEK 326
Cdd:PTZ00300 151 ADLQFGVEQGVDMIFASFIRSAEQVGEVRKALGAKGGD-IMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEK 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 327 MFLVEKVVIGKCMNVGKPV-----MLAFHVPNCGQPRIDMNLIANAVLTGTDGIFLKTGTLNCKQTSELLKNIDVICREA 401
Cdd:PTZ00300 230 VVVAQKILISKCNVAGKPVicatqMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEA 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 402 ESARWQREIFNDLSHKIAIPLDPSQAIIVGAIETCSKSNAAAIIVTTTSGRTATMLSLYRPRCPIVAITRYGIVARSLQL 481
Cdd:PTZ00300 310 QSAVNEYVFFNSIKKLQPIPMSAEEAVCSSAVNSVYETKAKALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNI 389

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 805752177 482 YHGLYPLHYINPPLCDwSKDMETRIESGVNFLRRKKYIKVGDAIIIVSGWRQGIGFTNCIRIIYV 546
Cdd:PTZ00300 390 TQGVESVFFDAERLGH-DEGKEQRVAMGVGFAKSKGYVQSGDLMVVVHADHKVKGYANQTRIILV 453
PRK06354 PRK06354
pyruvate kinase; Provisional
 61-543 2.53e-67

pyruvate kinase; Provisional


Pssm-ID: 235784 [Multi-domain]  Cd Length: 590  Bit Score: 228.66  E-value: 2.53e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177  61 RLTKLMVTLGNANSHPEAIVEMMMAGANIVRLNMSHEQEKWHAITVQSIREAGNRMYEytsdiyPLGVAMNLRGPEIRTG 140
Cdd:PRK06354   8 RRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKLGK------TVGILQDLQGPKIRLG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 141 IFNGDPLNrgyaqLKEGGIVRLVTNDLAkraGSACCFWISYPNLPRVCRPGDKILIDRGAAILQVRCV--RETSLVCKVI 218
Cdd:PRK06354  82 RFEDGPIE-----LKTGDEFILTSREVL---GTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVEEVdkADGELHCKVL 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 219 KGGIIKDEKLVQLMDSIIPLPQISETDNEHIRLAADLECDILIANHVRNKRLINGIKSRLKQIGANKVCVMAKISSQQGL 298
Cdd:PRK06354 154 VGGVLSNKKGVNFPGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIEEHNGKHIPIIAKIEKQEAI 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 299 ENFDEILGAADAILLDRKSVEIDVGPEKMFLVEKVVIGKCMNVGKPV-----MLAFHVPNCGQPRIDMNLIANAVLTGTD 373
Cdd:PRK06354 234 DNIDAILELCDGLMVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVitatqMLDSMQRNPRPTRAEASDVANAILDGTD 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 374 GIFLKTGTLNCKQTSELLKNIDVICREAESARWQREIFNDLSH-KIAIPLDPSQAiiVGaiETCSKSNAAAIIVTTTSGR 452
Cdd:PRK06354 314 AVMLSNETAAGDYPVEAVQTMATIAVRIEKDLPYRDILSKRPEfTTTITNAISQA--VS--HIALQLDAAAIVTLTKSGA 389

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 453 TATMLSLYRPRCPIVAITRYGIVARSLQLYHGLYPLHYINPPLCDwskdmETrIESGVNFLRRKKYIKVGDAIIIVSGWR 532
Cdd:PRK06354 390 TARNVSKYRPKTPILAVTPNESVARRLQLVWGVTPLLVLDAPSTD-----ET-FDAAINVAQESGLLKQGDLVVITAGTL 463

                        490
                 ....*....|..
gi 805752177 533 QGI-GFTNCIRI 543
Cdd:PRK06354 464 VGEsGSTDLMKV 475
PTZ00066 PTZ00066
pyruvate kinase; Provisional
 48-547 2.47e-66

pyruvate kinase; Provisional


Pssm-ID: 173361 [Multi-domain]  Cd Length: 513  Bit Score: 224.26  E-value: 2.47e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177  48 NINLDITCCPK-----VARLTKLMVTLGNANSHPEAIVEMMMAGANIVRLNMSHEQEKWHAITVQSIREAGNRMYEYTsd 122
Cdd:PTZ00066  20 NISLDKILEPIsdndlRQKKTHIVCTMGPACKNVETLVKLIDAGMNICRFNFSHGDHESHKKTLNNVREAAKARPNAN-- 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 123 iypLGVAMNLRGPEIRTGIF-NGDPLnrgyaQLKEGGIVRLVTNdlAKRAGSACCFWISYPNLPRVCRPGDKILIDRGAA 201
Cdd:PTZ00066  98 ---LGILLDTKGPEIRTGFLkNHKPI-----TLKEGQTLKITTD--YTFLGDETCISCSYKKLPQSVKVGNIILIADGSL 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 202 ILQVRCVRETSLVCKVIKGGIIKDEKLVQLMDSIIPLPQISETDNEHI-RLAADLECDILIANHVRNKRLINGIKSRLKQ 280
Cdd:PTZ00066 168 SCKVLEVHDDYIITKVLNNATIGERKNMNLPGVKVELPVIGEKDKNDIlNFAIPMGCDFIALSFVQSADDVRLCRQLLGE 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 281 IGANkVCVMAKISSQQGLENFDEILGAADAILLDRKSVEIDVGPEKMFLVEKVVIGKCMNVGKPV-----MLAFHVPNCG 355
Cdd:PTZ00066 248 RGRH-IKIIPKIENIEGLINFDEILAESDGIMVARGDLGMEIPPEKVFLAQKMMISKCNVAGKPVitatqMLESMIKNPR 326

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 356 QPRIDMNLIANAVLTGTDGIFLKTGTLNCKQTSELLKNIDVICREAESARWQREIFNDLSHKIAIPLDPSQAIIVGAIET 435
Cdd:PTZ00066 327 PTRAESTDVANAVLDGTDCVMLSGETANGKFPVEAVNIMAKICFEAETCIDYRVLYHAIHLAVPTPVSVQEAVARSAVET 406

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 436 CSKSNAAAIIVTTTSGRTATMLSLYRPRCPIVAITRYGIVARSLQLYHGLypLHYINPPLcdwsKDMETRIESGVNFLRR 515
Cdd:PTZ00066 407 AEDINAKLIIALTETGNTARLISKYRPSCTILALSASPSVVKSLSVARGV--TTYVVNSF----QGTDVVIRNAIALAKE 480

                        490       500       510
                 ....*....|....*....|....*....|...
gi 805752177 516 KKYIKVGDAIIIVSGWRQGI-GFTNCIRIIYVP 547
Cdd:PTZ00066 481 RGLVESGDSAIAVHGVKEEVaGSSNLMKVVKIP 513
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 60-411 2.83e-65

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 216.47  E-value: 2.83e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177   60 ARLTKLMVTLGNANSHPEAIVEMMMAGANIVRLNMSHEQEKWHAITVQSIREAgnrmyeytSDIYP--LGVAMNLRGPEI 137
Cdd:pfam00224   1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREA--------EEKTGgtVAIALDTKGPEI 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177  138 RTGIFNGDPLNrgyAQLKEGGIVRLVTNDLAKRAGSACCFWISYPNLPRVCRPGDKILIDRGAAILQVR-CVRETSLVCK 216
Cdd:pfam00224  73 RTGNTKDGKKD---IELKAGDEMIVSTDAKYKGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLsKDDDKTLVVE 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177  217 VIKGGIIKDEKLVQLMDSIIPLPQISETDNEHIRLAADLECDILIANHVRNKRLINGIKSRLKQIGANkVCVMAKISSQQ 296
Cdd:pfam00224 150 VLNGGVIGSRKGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKN-IQIIAKIENQE 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177  297 GLENFDEILGAADAILLDRKSVEIDVGPEKMFLVEKVVIGKCMNVGKPV-----MLAFHVPNCGQPRIDMNLIANAVLTG 371
Cdd:pfam00224 229 GVNNFDEILEATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVitatqMLESMIYNPRPTRAEVSDVANAVLDG 308

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 805752177  372 TDGIFLKTGTLNCKQTSELLKNIDVICREAESARWQREIF 411
Cdd:pfam00224 309 TDCVMLSGETAKGNYPVEAVRMMHEICLEAEKALPHRNLF 348
PRK06247 PRK06247
pyruvate kinase; Provisional
 58-549 8.66e-62

pyruvate kinase; Provisional


Pssm-ID: 180487 [Multi-domain]  Cd Length: 476  Bit Score: 210.94  E-value: 8.66e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177  58 KVARLTKLMVTLGNANSHPEAIVEMMMAGANIVRLNMSHEQEKWHAITVQSIREAgnrmyeytSDIY--PLGVAMNLRGP 135
Cdd:PRK06247   2 KRNRRVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREV--------EDETgrPIGILADLQGP 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 136 EIRTGIFNGDPlnrgyAQLKEGGIVRLvtnDLAKRAGSACCFWISYPNLPRVCRPGDKILIDRGAAILQVRCVRETSLVC 215
Cdd:PRK06247  74 KLRLGRFADGK-----VQLANGQTFRL---DVDDAPGDHDRVSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDGDDVVC 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 216 KVIKGGIIKDEKLVQLMDSIIPLPQISETDNEHIRLAADLECDILIANHVRNKRLINGIksrlKQIGANKVCVMAKISSQ 295
Cdd:PRK06247 146 RVVEGGPVSDRKGVSLPGTVLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEV----RKIIGGRVPVMAKIEKP 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 296 QGLENFDEILGAADAILLDRKSVEIDVGPEKMFLVEKVVIGKCMNVGKPV-----MLAFHVPNCGQPRIDMNLIANAVLT 370
Cdd:PRK06247 222 QAIDRLEAIVEASDAIMVARGDLGVEVPLEQVPLIQKRIIRAARRAGKPVvvatqMLESMIENPVPTRAEVSDVATAVLD 301

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 371 GTDGIFLKTGTLNCKQTSELLKNIDVICREAEsarwQREIFNDLSHkiaIPLDPSQAIIVGAI-----ETCSKSNAAAII 445
Cdd:PRK06247 302 GADAVMLSAETASGKYPVEAVRTMARIIRQVE----RDPTYPPLIH---AQRPQPEATKRDAIsyaarDIAERLDLAALV 374

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 446 VTTTSGRTATMLSLYRPRCPIVAITRYGIVARSLQLYHGLYPLhyinppLCDWSKDMETRIESGVNFLRRKKYIKVGDAI 525
Cdd:PRK06247 375 AYTSSGDTALRAARERPPLPILALTPNPETARRLALTWGVHCV------VVDDARDTDDMVRRADRIALAEGFYKRGDRV 448

                        490       500
                 ....*....|....*....|....*
gi 805752177 526 IIVSGWRQGI-GFTNCIRIIYVPPE 549
Cdd:PRK06247 449 VIVAGVPPGTpGSTNMLRIAYIGED 473
PRK09206 PRK09206
pyruvate kinase PykF;
63-543 1.01e-57

pyruvate kinase PykF;


Pssm-ID: 181699 [Multi-domain]  Cd Length: 470  Bit Score: 199.90  E-value: 1.01e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177  63 TKLMVTLGNANSHPEAIVEMMMAGANIVRLNMSHEQEKWHAITVQSIREAGNRMYEytsdiyPLGVAMNLRGPEIRTGif 142
Cdd:PRK09206   4 TKIVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVMSKTGK------KAAILLDTKGPEIRTM-- 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 143 ngdplnrgyaQLKEGGIVRLV-------TNDlAKRAGSACCFWISYPNLPRVCRPGDKILIDRGAAILQVRCVRETSLVC 215
Cdd:PRK09206  76 ----------KLEGGNDVSLKagqtftfTTD-KSVVGNKERVAVTYEGFTADLSVGNTVLVDDGLIGMEVTAITGNEVIC 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 216 KVIKGGIIKDEKLVQLMDSIIPLPQISETDNEHIRLAADLECDILIANHVRNKRLINGIKSRLKQIGANKVCVMAKISSQ 295
Cdd:PRK09206 145 KVLNNGDLGENKGVNLPGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAHGGENIQIISKIENQ 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 296 QGLENFDEILGAADAILLDRKS--VEIDVgpEKMFLVEKVVIGKCMNVGKPV-----MLAFHVPNCGQPRIDMNLIANAV 368
Cdd:PRK09206 225 EGLNNFDEILEASDGIMVARGDlgVEIPV--EEVIFAQKMMIEKCNRARKVVitatqMLDSMIKNPRPTRAEAGDVANAI 302

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 369 LTGTDGIFLKTGTLNCKQTSELLKNIDVICREAESARWQREIFNDLSHKIAIpldpSQAIIVGAIETCSKSNAAAIIVTT 448
Cdd:PRK09206 303 LDGTDAVMLSGESAKGKYPLEAVSIMATICERTDRVMNSRLESNNDNRKLRI----TEAVCRGAVETAEKLDAPLIVVAT 378

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 449 TSGRTATMLSLYRPRCPIVAITRYGIVARSLQLYHGLYPLhyinpplcdwskdMETRIESGVNFLRRKK-------YIKV 521
Cdd:PRK09206 379 QGGKSARSVRKYFPDATILALTTNEKTARQLVLSKGVVPQ-------------LVKEIASTDDFYRLGKelalqsgLAQK 445

                        490       500
                 ....*....|....*....|..
gi 805752177 522 GDAIIIVSGWRQGIGFTNCIRI 543
Cdd:PRK09206 446 GDVVVMVSGALVPSGTTNTASV 467
PLN02765 PLN02765
pyruvate kinase
 62-544 1.99e-56

pyruvate kinase


Pssm-ID: 215409 [Multi-domain]  Cd Length: 526  Bit Score: 197.97  E-value: 1.99e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177  62 LTKLMVTLGNANSHPEAIVEMMMAGANIVRLNMSHEQEKWHAITVQSIREAGNRMYEYTsdiyplGVAMNLRGPEIRTgi 141
Cdd:PLN02765  29 LTKIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEYHQETLENLKIAVKNTKKLC------AVMLDTVGPELQV-- 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 142 fngdpLNRGYAQ--LKEGGIVRLvTNDLAKRAgSACCFWISYPNLPRVCRPGDKILI--------DRGAAILQVRCVRET 211
Cdd:PLN02765 101 -----INKTEKPisLKAGNTVTL-TPDQSKEA-SSEVLPINFPGLAKAVKPGDTIFVgqylftgsETTSVWLEVDEVKGD 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 212 SLVCKVIKGGIIKDEKLVQLMDSI-IPLPQISETDNEHIR-LAADLECDILIANHVRNKRLINGIKSRLKQIGANKVCVM 289
Cdd:PLN02765 174 DVVCTVKNSATLAGSLFTLHVSQVrIDLPTLSEKDKEVIStWGVPNKIDFLSLSYTRHAEDVREAREFLSSLGLSQTQIF 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 290 AKISSQQGLENFDEILGAADAILLDRKSVEIDVGPEKMFLVEKVVIGKCMNVGKPVMLAFHV----PNCGQPRIDMNLIA 365
Cdd:PLN02765 254 AKIENVEGLTHFDEILQEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAVVTRVVdsmtDNLRPTRAEATDVA 333

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 366 NAVLTGTDGIFLKTGTLNCKQTSELLKNIDVICREAESARWQREIFNDLSHKIAIPLDPSQAIIVGAIETCSKSNAAAII 445
Cdd:PLN02765 334 NAVLDGADAILLGAETLRGLYPVETISTVGRICAEAEKVFNQDLYFKKTVKYVGEPMSHLESIASSAVRAAIKVKASVII 413

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 446 VTTTSGRTATMLSLYRPRCPIVAI------------TRYGIV-ARSLQLYHGLYPLhYINP--PLCDWSKDMETRIESGV 510
Cdd:PLN02765 414 VFTSSGRAARLIAKYRPTMPVLSVviprlktnqlkwSFTGAFqARQCLIVRGLFPM-LADPrhSAESTSATNESVLKVAL 492

                        490       500       510
                 ....*....|....*....|....*....|....
gi 805752177 511 NFLRRKKYIKVGDAIIIVsgwrQGIGFTNCIRII 544
Cdd:PLN02765 493 DHGKAAGVIKSHDRVVVC----QKVGDSSVVKII 522
PLN02461 PLN02461
Probable pyruvate kinase
 63-547 1.84e-55

Probable pyruvate kinase


Pssm-ID: 215255 [Multi-domain]  Cd Length: 511  Bit Score: 194.81  E-value: 1.84e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177  63 TKLMVTLGNANSHPEAIVEMMMAGANIVRLNMSHEQEKWHAITVQSIREAGNrmyeyTSDIyPLGVAMNLRGPEIRTGIF 142
Cdd:PLN02461  23 TKIVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLRQAMA-----NTGI-LCAVMLDTKGPEIRTGFL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 143 -NGDPLnrgyaQLKEGGIVRLVTNDLAKraGSACCFWISYPNLPRVCRPGDKILIDRGAAILQV-RCVRETSLV-CKVIK 219
Cdd:PLN02461  97 kDGKPV-----QLKQGQEITITTDYSIK--GDENMIAMSYKKLAVDVKPGSVILCADGTITLTVlSCDVEAGTVrCRCEN 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 220 GGIIKDEKLVQLMDSIIPLPQISETDNEHIrlaadLE------CDILIANHVRNKRLINGIKSRLKQiGANKVCVMAKIS 293
Cdd:PLN02461 170 SAMLGERKNVNLPGVVVDLPTLTEKDKEDI-----LQwgvpnkIDFIALSFVRKGSDLVEVRKVLGE-HAKSILLISKVE 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 294 SQQGLENFDEILGAADAILLDRKSVEIDVGPEKMFLVEKVVIGKCMNVGKPV-----MLAFHVPNCGQPRIDMNLIANAV 368
Cdd:PLN02461 244 NQEGLDNFDDILAESDAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVvtatqMLESMIKSPRPTRAEATDVANAV 323

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 369 LTGTDGIFLKTGTLNCKQTSELLKNIDVICREAESARWQREIFNDLSHKIAIPLDPSQAIIVGAIETCSKSNAAAIIVTT 448
Cdd:PLN02461 324 LDGTDCVMLSGETAAGAYPELAVKTMARICREAEASLDYGALFKEIMRSAPLPMSPLESLASSAVRTANKVKASLIVVLT 403

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 449 TSGRTATMLSLYRPRCPIVA-----ITRYGI--------VARSLQLYHGLYPLHYINPPLCDWSKDMETRIESGVNFLRR 515
Cdd:PLN02461 404 RGGTTARLVAKYRPAVPILSvvvpeITTDSFdwscsdeaPARHSLIYRGLIPVLAEGSAKATDSESTEEILEAAIEHAKK 483

                        490       500       510
                 ....*....|....*....|....*....|..
gi 805752177 516 KKYIKVGDAIIIVsgwrQGIGFTNCIRIIYVP 547
Cdd:PLN02461 484 KGLCKPGDSVVAL----HRIGGASVIKILTVK 511
PLN02623 PLN02623
pyruvate kinase
 57-535 1.59e-40

pyruvate kinase


Pssm-ID: 215334 [Multi-domain]  Cd Length: 581  Bit Score: 155.09  E-value: 1.59e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177  57 PKVARLTKLMVTLGNANSHPEAIVEMMMAGANIVRLNMSHEQEKWHAITVQSIREagnrmYEYTSDIYPLGVAMNLRGPE 136
Cdd:PLN02623 106 PSVRRKTKIVCTIGPSTNTREMIWKLAEAGMNVARLNMSHGDHASHQKVIDLVKE-----YNAQSKDNVIAIMLDTKGPE 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 137 IRTGIFNgDPLnrgyaQLKEGgivRLVTNDLAKRAGSACCFWISYPNLPRVCRPGDKILIDRGAAILQVRCVRETSLVCK 216
Cdd:PLN02623 181 VRSGDLP-QPI-----MLEEG---QEFTFTIKRGVSTEDCVSVNYDDFVNDVEVGDMLLVDGGMMSLAVKSKTSDSVKCE 251

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 217 VIKGGIIKDEKLVQLMDSIIPLPQISETDNEHIRLAADLECDILIANHVRNKRLINGIKSRLKQIGANkVCVMAKISSQQ 296
Cdd:PLN02623 252 VVDGGELKSRRHLNVRGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKDYLKSCNAD-IHVIVKIESAD 330

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 297 GLENFDEILGAADAILLDRKSVEIDVGPEKMFLVEKVVIGKCMNVGKPV-----MLAFHVPNCGQPRIDMNLIANAVLTG 371
Cdd:PLN02623 331 SIPNLHSIITASDGAMVARGDLGAELPIEEVPLLQEEIIRRCRSMGKPVivatnMLESMIVHPTPTRAEVSDIAIAVREG 410

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 372 TDGIFLKTGTLNCKQTSELLKNIDVICREAESARWQREIFNDLSHkiAIPLDPSQAIIVGAiETCSKSNAAAIIVTTTSG 451
Cdd:PLN02623 411 ADAVMLSGETAHGKFPLKAVKVMHTVALRTEATLPEGTTPPNLGQ--AFKNHMSEMFAFHA-TMMANTLGTSIIVFTRTG 487

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 452 RTATMLSLYRPRCPIVAITRYGIVARSLQLYHGLYPLHYinpplcDWSKDMETRIESGVNFLRRKKYIKVGDAIIIVSGW 531
Cdd:PLN02623 488 FMAILLSHYRPSGTIFAFTNEKRIQQRLALYQGVCPIYM------QFSDDAEETFARALSLLLNKGMVKEGEEVALVQSG 561


                 ....
gi 805752177 532 RQGI 535
Cdd:PLN02623 562 RQPI 565
PLN02762 PLN02762
pyruvate kinase complex alpha subunit
 60-529 2.55e-37

pyruvate kinase complex alpha subunit


Pssm-ID: 215407 [Multi-domain]  Cd Length: 509  Bit Score: 144.89  E-value: 2.55e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177  60 ARLTKLMVTLGNANSHPEAIVEMMMAGANIVRLNMSHEQEKWHAITVQSIReagnRMYEYTSdiYPLGVAMNLRGPEIRT 139
Cdd:PLN02762  24 TRRTKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVR----RLNEEKG--FAVAVMMDTEGSEIHM 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 140 GIFNGDPlnrgyAQLKEGGIVRLVTNDLAKRAGSACCFWISYPNLPRVCRPGDKILIDRGAAILQVRCVRETSLVCKVIK 219
Cdd:PLN02762  98 GDLGGAS-----SAKAEDGEEWTFTVRKFDGSRPEFTIQVNYDGFAEDVKVGDELVVDGGMVRFEVIEKIGPDVKCKCTD 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 220 GGII---------KDEKLVQlmDSIIPLPQISETDNEHIRLAADLECDILIANHVRNKRLINGIKSRLKQIGAN-KVCVM 289
Cdd:PLN02762 173 PGLLlpranltfwRDGSLVR--ERNAMLPTISSKDWLDIDFGISEGVDFIAVSFVKSAEVIKHLKSYIAARSRDsDIGVI 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 290 AKISSQQGLENFDEILGAADAILLDRKSVEIDVGPEKMFLVEKVVIGKCMNVGKPV---------MLAFHVPNcgqpRID 360
Cdd:PLN02762 251 AKIESLDSLKNLEEIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVivasqllesMIEYPTPT----RAE 326

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 361 MNLIANAVLTGTDGIFLK----TGTLNCKQTSELLK---NIDVICREA--ESARWQREIFNDLSHKIaipldpSQAIIVG 431
Cdd:PLN02762 327 VADVSEAVRQRADALMLSgesaMGLYPEKALSVLRSvslRMELWSREEkrHEALELPQLSSSLSDRI------SEEICNS 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 432 AIETCSKSNAAAIIVTTTSGRTATMLSLYRPRCPIVAITRYGIVARSLQLYHGLYPLHYinpplcDWSKDMETRIESGVN 511
Cdd:PLN02762 401 AAKMANNLGVDAIFVYTKHGHMASLLSRNRPDCPIFAFTDTTSVRRRLNLQWGLIPFRL------DFSDDMESNLNKTFS 474

                        490
                 ....*....|....*...
gi 805752177 512 FLRRKKYIKVGDAIIIVS 529
Cdd:PLN02762 475 LLKARGMIKSGDLVIAVS 492
PK_C pfam02887
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ...
 426-544 6.56e-32

Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.


Pssm-ID: 460738 [Multi-domain]  Cd Length: 114  Bit Score: 119.12  E-value: 6.56e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177  426 QAIIVGAIETCSKSNAAAIIVTTTSGRTATMLSLYRPRCPIVAITRYGIVARSLQLYHGLYPLHYINPplcdwsKDMETR 505
Cdd:pfam02887   1 EAIAHAAVEAAEELGAKAIVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFDEA------ETTDEM 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 805752177  506 IESGVNFLRRKKYIKVGDAIIIVSGWRQGI-GFTNCIRII 544
Cdd:pfam02887  75 LRRAVKVAKEAGLVKKGDLVVITAGVPFGVsGTTNTLKVI 114
PykA2 COG3848
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
337-546 1.12e-17

Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];


Pssm-ID: 443058  Cd Length: 321  Bit Score: 84.18  E-value: 1.12e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 337 KCMNVGKPV-----MLAFHVPNCGQPRIDMNLIANAVLTGTDGIFLKTGTLNCKQTSELLKNIDVICREAESARWQREIF 411
Cdd:COG3848    1 KCNAAGKPVitatqMLDSMMRNPRPTRAEAADVANAIFDGTDAIMLSGETAAGKYPVEAVVTMVRIAERAEEDLEYREQR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 412 NdlSHKIAIPLDPSQAIIVGAIETCSKSNAAAIIVTTTSGRTATMLSLYRPRCPIVAITRYGIVARSLQLYHGLYPLhyi 491
Cdd:COG3848   81 V--PRAKESSTTITDAISHAVATTAADLGAAAIITATESGATARMVSKYRPKAPIIAVTPSERVARQLSLVWGVYPL--- 155

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 805752177 492 nppLCDWSKDMETRIESGVNFLRRKKYIKVGDAIIIVSGWRQGI-GFTNCIRIIYV 546
Cdd:COG3848  156 ---LVEESASTDEMFAVAVALALEAGLVKDGDLVVITAGVPVGVsGTTNLLKVHVV 208
PRK08187 PRK08187
pyruvate kinase; Validated
 60-308 1.34e-15

pyruvate kinase; Validated


Pssm-ID: 236178  Cd Length: 493  Bit Score: 79.67  E-value: 1.34e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177  60 ARLTKLMVTL-GNANSHPEAIVEMMMAGANIVRLNMSHEQEK-WHAItVQSIREA----GNRMyeytsdiyplGVAMNLR 133
Cdd:PRK08187 132 ARRTRIMVTLpSEAADDPDFVLRLAERGMDCARINCAHDDPAaWQAM-IGHLRQAeratGRRC----------KILMDLA 200

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 134 GPEIRTG-IFNGDPLNRgyaqLKEGGIVRLVTnDLAKRAGSACCFWI--SYPN-LPRVcRPGDKILIDRGAAILQVRCVR 209
Cdd:PRK08187 201 GPKIRTGaVAGPLGKTR----LYTGDRLALVA-QGPPRRIDEEHFQVtcTLPEiLARL-AVGARVWIDDGKLGARVERVG 274

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 210 ETSLVCKVI----KGGIIKDEKLVQLMDSIIPLPQISETDNEHIRLAADlECDILIANHVRN----KRLINGIKSRLkQI 281
Cdd:PRK08187 275 PGGALLEVTharpKGLKLKPEKGLNFPDTALDLPALTEKDRADLDFVAR-HADLVGYSFVQSpgdvEALQAALAARR-PD 352

                        250       260
                 ....*....|....*....|....*..
gi 805752177 282 GANKVCVMAKISSQQGLENFDEILGAA 308
Cdd:PRK08187 353 DWRKLGLVLKIETPRAVANLPELIVQA 379
PRK14725 PRK14725
pyruvate kinase; Provisional
 61-327 6.12e-07

pyruvate kinase; Provisional


Pssm-ID: 237804  Cd Length: 608  Bit Score: 52.26  E-value: 6.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177  61 RLTKLMVTL-GNANSHPEAIVEMMMAGANIVRLNMSHE-QEKWHAItVQSIREAGNRmyeytsdiypLG----VAMNLRG 134
Cdd:PRK14725 139 RPTRIMVTLpTEAADDPDLVRRLLAAGMDIARINCAHDdPEAWRAM-IANVRTAEEE----------LGrrcrIAMDLAG 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 135 PEIRTG-----------------------------IFNGDPLN-------------RGYAQLKEGGIVRL---------- 162
Cdd:PRK14725 208 PKLRTGpiapgprviklrptrdalgrvltparlwlTASESPPPspppgpvglpvdpEWLARLEPGDELRFtdargkkrkl 287

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 163 ----VTNDLAKRAGSACCFWIS----------------------------------------------YPNLPRV-C--- 188
Cdd:PRK14725 288 tvteVDDEGVLAEGSQTAYLANgtllrlgrhdstrvgglppveqklrlkvgdrlvltrddapgdpaqgDAPPARIsCtlp 367

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 805752177 189 ------RPGDKILIDRGAAILQVRCVRETSLVCKVI----KGGIIKDEKLVQLMDSIIPLPQISETDNEHIRLAADLeCD 258
Cdd:PRK14725 368 eafraaRVGERVWFDDGKIGAVVVKVEADEVELRITharpGGSKLKAGKGINLPDSHLPLPALTDKDLEDLAFVAKH-AD 446

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 805752177 259 ILIANHVRNKRLINGIKSRLKQIGANKVCVMAKISSQQGLENFDEILGAA-----DAILLDRKSVEIDVGPEKM 327
Cdd:PRK14725 447 IVALSFVRSPEDVRLLLDALEKLGADDLGVVLKIETRRAFENLPRILLEAmrhprFGVMIARGDLAVEVGFERL 520
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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