NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|383847164|ref|XP_003699225|]
View 

PREDICTED: frataxin homolog, mitochondrial [Megachile rotundata]

Protein Classification

frataxin( domain architecture ID 10022430)

frataxin is a mitochondrial protein that promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways

CATH:  3.30.920.10
Gene Ontology:  GO:0008199|GO:0008198|GO:0016226|GO:0051537|GO:0004322
SCOP:  4001566
TCDB:  9.B.21

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
mito_frataxin TIGR03422
frataxin; Frataxin is a mitochondrial protein, mutation of which leads to the disease ...
 85-182 3.78e-54

frataxin; Frataxin is a mitochondrial protein, mutation of which leads to the disease Friedreich's ataxia. Its orthologs are widely distributed in the bacteria, associated with the ISC system for iron-sulfur cluster assembly, and designated CyaY. This exception-type model allows those examples of frataxin per se that score above the trusted cutoff to the CyaY equivalog-type model (TIGR03421) to be named appropriately.


:

Pssm-ID: 132463  Cd Length: 97  Bit Score: 167.80  E-value: 3.78e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383847164   85 QFEKVSDETLESLTEYFDELIEKAAHLqDADISYGDGVLTIKFGSkYGTYVINRQTPNKQIWLSSPKSGPKRYDFVNGKW 164
Cdd:TIGR03422   1 EYHKVADEYLDHLLDKLEELGESRPDL-DFDVEYSSGVLTLELPS-VGTYVINKQPPNKQIWLSSPVSGPKRYDYVNGEW 78

                          90
                  ....*....|....*...
gi 383847164  165 IYKHDGKSLHELLNNEIP 182
Cdd:TIGR03422  79 IYLRDGSSLTELLEEELS 96
 
Name Accession Description Interval E-value
mito_frataxin TIGR03422
frataxin; Frataxin is a mitochondrial protein, mutation of which leads to the disease ...
 85-182 3.78e-54

frataxin; Frataxin is a mitochondrial protein, mutation of which leads to the disease Friedreich's ataxia. Its orthologs are widely distributed in the bacteria, associated with the ISC system for iron-sulfur cluster assembly, and designated CyaY. This exception-type model allows those examples of frataxin per se that score above the trusted cutoff to the CyaY equivalog-type model (TIGR03421) to be named appropriately.


Pssm-ID: 132463  Cd Length: 97  Bit Score: 167.80  E-value: 3.78e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383847164   85 QFEKVSDETLESLTEYFDELIEKAAHLqDADISYGDGVLTIKFGSkYGTYVINRQTPNKQIWLSSPKSGPKRYDFVNGKW 164
Cdd:TIGR03422   1 EYHKVADEYLDHLLDKLEELGESRPDL-DFDVEYSSGVLTLELPS-VGTYVINKQPPNKQIWLSSPVSGPKRYDYVNGEW 78

                          90
                  ....*....|....*...
gi 383847164  165 IYKHDGKSLHELLNNEIP 182
Cdd:TIGR03422  79 IYLRDGSSLTELLEEELS 96
Frataxin_Cyay pfam01491
Frataxin-like domain; This family contains proteins that have a domain related to the globular ...
 81-185 1.40e-49

Frataxin-like domain; This family contains proteins that have a domain related to the globular C-terminus of Frataxin the protein that is mutated in Friedreich's ataxia. This domain is found in a family of bacterial proteins. The function of this domain is currently unknown. It has been suggested that this family is involved in iron transport.


Pssm-ID: 460230  Cd Length: 106  Bit Score: 156.53  E-value: 1.40e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383847164   81 LSPVQFEKVSDETLESLTEYFDELIEKaahLQDADISYGDGVLTIKFGSkYGTYVINRQTPNKQIWLSSPKSGPKRYDFV 160
Cdd:pfam01491   1 MTDSEFHRLADATLESLEDSLEELLDE---GSDADVEYSGGVLTLEFDN-GGTYVINKQPPNRQIWLSSPISGPFHFDYD 76

                          90       100
                  ....*....|....*....|....*.
gi 383847164  161 N-GKWIYKHDGKSLHELLNNEIPAII 185
Cdd:pfam01491  77 DaGQWIYTRDGEELFELLSRELSEQL 102
Frataxin cd00503
Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), ...
 86-184 2.06e-40

Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate in the mitochondrial matrix suggesting that frataxin is involved in mitochondrial iron homeostasis and possibly in iron transport; the domain has an alpha-beta fold consisting of two helices flanking an antiparallel beta sheet.


Pssm-ID: 238280  Cd Length: 105  Bit Score: 133.16  E-value: 2.06e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383847164  86 FEKVSDETLESLTEYFDELIEKAahlqDADISYGDGVLTIKFGSKyGTYVINRQTPNKQIWLSSPkSGPKRYDFVNGKWI 165
Cdd:cd00503    6 FHRLADDLLLKIEDTLEEQDDDA----DIDVETQGGVLTLTFGNG-STIVINRQEPLRQIWLASK-VGGYHFDYKNGKWI 79

                         90
                 ....*....|....*....
gi 383847164 166 YKHDGKSLHELLNNEIPAI 184
Cdd:cd00503   80 CTRSGEELWELLEEECSAQ 98
CyaY COG1965
Fe-S cluster assembly protein CyaY, frataxin homolog [Inorganic ion transport and metabolism]; ...
 85-181 9.41e-21

Fe-S cluster assembly protein CyaY, frataxin homolog [Inorganic ion transport and metabolism]; Fe-S cluster assembly protein CyaY, frataxin homolog is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441568  Cd Length: 106  Bit Score: 82.92  E-value: 9.41e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383847164  85 QFEKVSDETLESLTEYFDELiekaahlQDADISY--GDGVLTIKF--GSKYgtyVINRQTPNKQIWLSSpKSGPKRYDFV 160
Cdd:COG1965    5 EFHQLADALLEAIEEALDRD-------DDADIDCerSGGVLTLEFdnGSKI---IINRQEPLRQIWLAA-KSGGFHFDYD 73

                         90       100
                 ....*....|....*....|.
gi 383847164 161 NGKWIYKHDGKSLHELLNNEI 181
Cdd:COG1965   74 DGKWIDTRSGEELFALLSRAL 94
cyaY PRK00446
frataxin-like protein; Provisional
 81-181 1.05e-16

frataxin-like protein; Provisional


Pssm-ID: 234765  Cd Length: 105  Bit Score: 72.22  E-value: 1.05e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383847164  81 LSPVQFEKVSDETLESLTEYFDELiekaahlQDADISYGD--GVLTIKF--GSKYgtyVINRQTPNKQIWLSSpKSGPKR 156
Cdd:PRK00446   1 MNDSEFHQLADALWQAIEEQLDDD-------GDADIDCERngGVLTLTFenGSKI---IINRQEPLHELWLAA-KSGGFH 69

                         90       100
                 ....*....|....*....|....*
gi 383847164 157 YDFVNGKWIYKHDGKSLHELLNNEI 181
Cdd:PRK00446  70 FDYKDGEWICDRSGEEFWALLEEAA 94
 
Name Accession Description Interval E-value
mito_frataxin TIGR03422
frataxin; Frataxin is a mitochondrial protein, mutation of which leads to the disease ...
 85-182 3.78e-54

frataxin; Frataxin is a mitochondrial protein, mutation of which leads to the disease Friedreich's ataxia. Its orthologs are widely distributed in the bacteria, associated with the ISC system for iron-sulfur cluster assembly, and designated CyaY. This exception-type model allows those examples of frataxin per se that score above the trusted cutoff to the CyaY equivalog-type model (TIGR03421) to be named appropriately.


Pssm-ID: 132463  Cd Length: 97  Bit Score: 167.80  E-value: 3.78e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383847164   85 QFEKVSDETLESLTEYFDELIEKAAHLqDADISYGDGVLTIKFGSkYGTYVINRQTPNKQIWLSSPKSGPKRYDFVNGKW 164
Cdd:TIGR03422   1 EYHKVADEYLDHLLDKLEELGESRPDL-DFDVEYSSGVLTLELPS-VGTYVINKQPPNKQIWLSSPVSGPKRYDYVNGEW 78

                          90
                  ....*....|....*...
gi 383847164  165 IYKHDGKSLHELLNNEIP 182
Cdd:TIGR03422  79 IYLRDGSSLTELLEEELS 96
Frataxin_Cyay pfam01491
Frataxin-like domain; This family contains proteins that have a domain related to the globular ...
 81-185 1.40e-49

Frataxin-like domain; This family contains proteins that have a domain related to the globular C-terminus of Frataxin the protein that is mutated in Friedreich's ataxia. This domain is found in a family of bacterial proteins. The function of this domain is currently unknown. It has been suggested that this family is involved in iron transport.


Pssm-ID: 460230  Cd Length: 106  Bit Score: 156.53  E-value: 1.40e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383847164   81 LSPVQFEKVSDETLESLTEYFDELIEKaahLQDADISYGDGVLTIKFGSkYGTYVINRQTPNKQIWLSSPKSGPKRYDFV 160
Cdd:pfam01491   1 MTDSEFHRLADATLESLEDSLEELLDE---GSDADVEYSGGVLTLEFDN-GGTYVINKQPPNRQIWLSSPISGPFHFDYD 76

                          90       100
                  ....*....|....*....|....*.
gi 383847164  161 N-GKWIYKHDGKSLHELLNNEIPAII 185
Cdd:pfam01491  77 DaGQWIYTRDGEELFELLSRELSEQL 102
Frataxin cd00503
Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), ...
 86-184 2.06e-40

Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate in the mitochondrial matrix suggesting that frataxin is involved in mitochondrial iron homeostasis and possibly in iron transport; the domain has an alpha-beta fold consisting of two helices flanking an antiparallel beta sheet.


Pssm-ID: 238280  Cd Length: 105  Bit Score: 133.16  E-value: 2.06e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383847164  86 FEKVSDETLESLTEYFDELIEKAahlqDADISYGDGVLTIKFGSKyGTYVINRQTPNKQIWLSSPkSGPKRYDFVNGKWI 165
Cdd:cd00503    6 FHRLADDLLLKIEDTLEEQDDDA----DIDVETQGGVLTLTFGNG-STIVINRQEPLRQIWLASK-VGGYHFDYKNGKWI 79

                         90
                 ....*....|....*....
gi 383847164 166 YKHDGKSLHELLNNEIPAI 184
Cdd:cd00503   80 CTRSGEELWELLEEECSAQ 98
FeS_CyaY TIGR03421
iron donor protein CyaY; Members of this protein family are the iron-sulfur cluster (FeS) ...
 85-181 2.57e-27

iron donor protein CyaY; Members of this protein family are the iron-sulfur cluster (FeS) metabolism protein CyaY, a homolog of eukaryotic frataxin. ISC is one of several bacterial systems for FeS assembly; we find by Partial Phylogenetic Profiling vs. the ISC system that CyaY most like work with the ISC system for FeS cluster biosynthesis. A study of of cyaY mutants in Salmonella enterica bears this out. Although the trusted cutoff is set low enough to include eukaryotic frataxin sequences, a narrower, exception-type model (TIGR03421) identifies identifies members of that specific set. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 274572  Cd Length: 102  Bit Score: 99.59  E-value: 2.57e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383847164   85 QFEKVSDETLESLTEYFDEliekaaHLQDADISYGDGVLTIKFGSKyGTYVINRQTPNKQIWLSSpKSGPKRYDFVNGKW 164
Cdd:TIGR03421   4 EFHQLAEALLDAIEEAIDD------GDADIDCERQGGVLTLTFENG-SQIIINKQEPLHQIWLAA-KSGGFHFDYDGGAW 75

                          90
                  ....*....|....*..
gi 383847164  165 IYKHDGKSLHELLNNEI 181
Cdd:TIGR03421  76 IDTRDGEELWALLARAC 92
CyaY COG1965
Fe-S cluster assembly protein CyaY, frataxin homolog [Inorganic ion transport and metabolism]; ...
 85-181 9.41e-21

Fe-S cluster assembly protein CyaY, frataxin homolog [Inorganic ion transport and metabolism]; Fe-S cluster assembly protein CyaY, frataxin homolog is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441568  Cd Length: 106  Bit Score: 82.92  E-value: 9.41e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383847164  85 QFEKVSDETLESLTEYFDELiekaahlQDADISY--GDGVLTIKF--GSKYgtyVINRQTPNKQIWLSSpKSGPKRYDFV 160
Cdd:COG1965    5 EFHQLADALLEAIEEALDRD-------DDADIDCerSGGVLTLEFdnGSKI---IINRQEPLRQIWLAA-KSGGFHFDYD 73

                         90       100
                 ....*....|....*....|.
gi 383847164 161 NGKWIYKHDGKSLHELLNNEI 181
Cdd:COG1965   74 DGKWIDTRSGEELFALLSRAL 94
cyaY PRK00446
frataxin-like protein; Provisional
 81-181 1.05e-16

frataxin-like protein; Provisional


Pssm-ID: 234765  Cd Length: 105  Bit Score: 72.22  E-value: 1.05e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383847164  81 LSPVQFEKVSDETLESLTEYFDELiekaahlQDADISYGD--GVLTIKF--GSKYgtyVINRQTPNKQIWLSSpKSGPKR 156
Cdd:PRK00446   1 MNDSEFHQLADALWQAIEEQLDDD-------GDADIDCERngGVLTLTFenGSKI---IINRQEPLHELWLAA-KSGGFH 69

                         90       100
                 ....*....|....*....|....*
gi 383847164 157 YDFVNGKWIYKHDGKSLHELLNNEI 181
Cdd:PRK00446  70 FDYKDGEWICDRSGEEFWALLEEAA 94
cyaY PRK01379
iron donor protein CyaY;
85-164 1.32e-08

iron donor protein CyaY;


Pssm-ID: 134546  Cd Length: 103  Bit Score: 50.70  E-value: 1.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 383847164  85 QFEKVSDETLESLTEYFDELIEKAAhlQDADISyGDgvlTIKFGSKYGTYVINRQTPNKQIWLSSPKSGPKRYDFVNGKW 164
Cdd:PRK01379   5 EFSKIAETTIAYIADKIEEQDKEAS--IDVDLQ-GD---ILNLDTDKGIYVINKQSAAKEIWLSSPVSGPYHFFYEQGKW 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH