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Conserved domains on  [gi|432867085|ref|XP_004071021|]
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spermatogenesis-associated serine-rich protein 2 isoform X1 [Oryzias latipes]

Protein Classification

UBA_like_SF and DUF1387 domain-containing protein( domain architecture ID 11707566)

UBA_like_SF and DUF1387 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF1387 pfam07139
Protein of unknown function (DUF1387); This family represents a conserved region approximately ...
 81-365 3.99e-135

Protein of unknown function (DUF1387); This family represents a conserved region approximately 300 residues long within a number of hypothetical proteins of unknown function that seem to be restricted to mammals.


:

Pssm-ID: 462100  Cd Length: 311  Bit Score: 392.56  E-value: 3.99e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432867085   81 WNVTG-KKKPKKKKKPKPQPEPSAEAVQPEAAMSEEGKDE--INGFHANGSVMDGESLDSLSEQLDSASLDAAELDSEPA 157
Cdd:pfam07139   1 WNVTGkKKNPKKKKKKKKQTEENKEAVPSERGGENGYHVNggINNDHENGCSFDTESVDSLSEILDSESTEAAALGGPES 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432867085  158 TSETTG------------AEAES---PGSAQSPASQQGGRNHQgPRGNKSRHRLGSNSHPP--TFPTATSDDPGSSGGKK 220
Cdd:pfam07139  81 SSSRLAngisdledpkcsADAEPqavSHSAPSPASQNAGRPLS-RNASKPKSRPSSNKSLLedAPLSSTDDKLGSSIEKK 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432867085  221 IASNIDRSVKDLQRCTASLTRYRMVVKEEMDSSIKRMKQTFAELQSCLMDREVTLLGEMDKVKAEAMLILDARQKRAEEL 300
Cdd:pfam07139 160 VGPNIEKSVKDLQRCTVSLTRYRVVIKEEMDASIKKIKATFAELQSCLMDREVALLAEMDKVKAEAMEILTARQKKAEEL 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 432867085  301 RRLTDKSASMSEEQLTELRADIKHFVSERKYDEDLGRALRFTFELEPLKTSISGFGSVYHPRTGY 365
Cdd:pfam07139 240 KRLTDLAVQMSEEQLVELRADIKHFVSERKYDEELGRAARFTCDLEQLKTSIPKFGEVSHPKNNY 304
UBA_like_SF super family cl21463
UBA domain-like superfamily; The ubiquitin-associated (UBA) domain-like superfamily contains ...
 33-72 8.54e-03

UBA domain-like superfamily; The ubiquitin-associated (UBA) domain-like superfamily contains alpha-helical structural homology ubiquitin-binding domains, including UBA domains and coupling of ubiquitin conjugation to endoplasmic reticulum degradation (CUE) domains which share a common three-helical bundle architecture. UBA domains are commonly occurring sequence motifs found in proteins involved in ubiquitin-mediated proteolysis. They contribute to ubiquitin (Ub) binding or ubiquitin-like (UbL) domain binding. However, some kinds of UBA domains can only bind the UbL domain, but not the Ub domain. UBA domains are normally comprised of compact three-helix bundles which contain a conserved GF/Y-loop. They can bind polyubiquitin with high affinity. They also bind monoubiquitin and other proteins. Most UBA domain-containing proteins have one UBA domain, but some harbor two or three UBA domains. CUE domain containing proteins are characterized by an FP and a di-leucine-like sequence and bind to monoubiquitin with varying affinities. Some higher eukaryotic CUE domain proteins do not bind monoubiquitin efficiently, since they carry LP, rather than FP among CUE domains. This superfamily also includes many UBA-like domains found in AMP-activated protein kinase (AMPK) related kinases, the NXF family of mRNA nuclear export factors, elongation factor Ts (EF-Ts), nascent polypeptide-associated complex subunit alpha (NACA) and similar proteins. Although many UBA-like domains may have a conserved TG but not GF/Y-loop, they still show a high level of structural and sequence similarity with three-helical ubiquitin binding domains.


The actual alignment was detected with superfamily member cd14364:

Pssm-ID: 473871  Cd Length: 40  Bit Score: 34.26  E-value: 8.54e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 432867085  33 KEKISAVRAVVPNKSNNEIVLVLQHFENSVDKAVQAFLEG 72
Cdd:cd14364    1 DSLISQVKDILPDLGEGFIEACLEHYNGNVERVINALLEG 40
 
Name Accession Description Interval E-value
DUF1387 pfam07139
Protein of unknown function (DUF1387); This family represents a conserved region approximately ...
 81-365 3.99e-135

Protein of unknown function (DUF1387); This family represents a conserved region approximately 300 residues long within a number of hypothetical proteins of unknown function that seem to be restricted to mammals.


Pssm-ID: 462100  Cd Length: 311  Bit Score: 392.56  E-value: 3.99e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432867085   81 WNVTG-KKKPKKKKKPKPQPEPSAEAVQPEAAMSEEGKDE--INGFHANGSVMDGESLDSLSEQLDSASLDAAELDSEPA 157
Cdd:pfam07139   1 WNVTGkKKNPKKKKKKKKQTEENKEAVPSERGGENGYHVNggINNDHENGCSFDTESVDSLSEILDSESTEAAALGGPES 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432867085  158 TSETTG------------AEAES---PGSAQSPASQQGGRNHQgPRGNKSRHRLGSNSHPP--TFPTATSDDPGSSGGKK 220
Cdd:pfam07139  81 SSSRLAngisdledpkcsADAEPqavSHSAPSPASQNAGRPLS-RNASKPKSRPSSNKSLLedAPLSSTDDKLGSSIEKK 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432867085  221 IASNIDRSVKDLQRCTASLTRYRMVVKEEMDSSIKRMKQTFAELQSCLMDREVTLLGEMDKVKAEAMLILDARQKRAEEL 300
Cdd:pfam07139 160 VGPNIEKSVKDLQRCTVSLTRYRVVIKEEMDASIKKIKATFAELQSCLMDREVALLAEMDKVKAEAMEILTARQKKAEEL 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 432867085  301 RRLTDKSASMSEEQLTELRADIKHFVSERKYDEDLGRALRFTFELEPLKTSISGFGSVYHPRTGY 365
Cdd:pfam07139 240 KRLTDLAVQMSEEQLVELRADIKHFVSERKYDEELGRAARFTCDLEQLKTSIPKFGEVSHPKNNY 304
CUE_ASCC2 cd14364
CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar ...
 33-72 8.54e-03

CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins; ASCC2, also called ASC-1 complex subunit p100 or Trip4 complex subunit p100, together with ASCC1 (also called p50) and ASCC3 (also called p300), form the activating signal cointegrator complex (ASCC). ASCC plays an essential role in activating protein 1 (AP-1), serum response factor (SRF), and nuclear factor kappaB (NF-kappaB) transactivation. It acts as a transcriptional coactivator of nuclear receptors and regulates the transrepression between nuclear receptors and either AP-1 or NF-kappaB in vivo. Members in this family all contain a CUE domain.


Pssm-ID: 270547  Cd Length: 40  Bit Score: 34.26  E-value: 8.54e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 432867085  33 KEKISAVRAVVPNKSNNEIVLVLQHFENSVDKAVQAFLEG 72
Cdd:cd14364    1 DSLISQVKDILPDLGEGFIEACLEHYNGNVERVINALLEG 40
 
Name Accession Description Interval E-value
DUF1387 pfam07139
Protein of unknown function (DUF1387); This family represents a conserved region approximately ...
 81-365 3.99e-135

Protein of unknown function (DUF1387); This family represents a conserved region approximately 300 residues long within a number of hypothetical proteins of unknown function that seem to be restricted to mammals.


Pssm-ID: 462100  Cd Length: 311  Bit Score: 392.56  E-value: 3.99e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432867085   81 WNVTG-KKKPKKKKKPKPQPEPSAEAVQPEAAMSEEGKDE--INGFHANGSVMDGESLDSLSEQLDSASLDAAELDSEPA 157
Cdd:pfam07139   1 WNVTGkKKNPKKKKKKKKQTEENKEAVPSERGGENGYHVNggINNDHENGCSFDTESVDSLSEILDSESTEAAALGGPES 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432867085  158 TSETTG------------AEAES---PGSAQSPASQQGGRNHQgPRGNKSRHRLGSNSHPP--TFPTATSDDPGSSGGKK 220
Cdd:pfam07139  81 SSSRLAngisdledpkcsADAEPqavSHSAPSPASQNAGRPLS-RNASKPKSRPSSNKSLLedAPLSSTDDKLGSSIEKK 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432867085  221 IASNIDRSVKDLQRCTASLTRYRMVVKEEMDSSIKRMKQTFAELQSCLMDREVTLLGEMDKVKAEAMLILDARQKRAEEL 300
Cdd:pfam07139 160 VGPNIEKSVKDLQRCTVSLTRYRVVIKEEMDASIKKIKATFAELQSCLMDREVALLAEMDKVKAEAMEILTARQKKAEEL 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 432867085  301 RRLTDKSASMSEEQLTELRADIKHFVSERKYDEDLGRALRFTFELEPLKTSISGFGSVYHPRTGY 365
Cdd:pfam07139 240 KRLTDLAVQMSEEQLVELRADIKHFVSERKYDEELGRAARFTCDLEQLKTSIPKFGEVSHPKNNY 304
CUE_ASCC2 cd14364
CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar ...
 33-72 8.54e-03

CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins; ASCC2, also called ASC-1 complex subunit p100 or Trip4 complex subunit p100, together with ASCC1 (also called p50) and ASCC3 (also called p300), form the activating signal cointegrator complex (ASCC). ASCC plays an essential role in activating protein 1 (AP-1), serum response factor (SRF), and nuclear factor kappaB (NF-kappaB) transactivation. It acts as a transcriptional coactivator of nuclear receptors and regulates the transrepression between nuclear receptors and either AP-1 or NF-kappaB in vivo. Members in this family all contain a CUE domain.


Pssm-ID: 270547  Cd Length: 40  Bit Score: 34.26  E-value: 8.54e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 432867085  33 KEKISAVRAVVPNKSNNEIVLVLQHFENSVDKAVQAFLEG 72
Cdd:cd14364    1 DSLISQVKDILPDLGEGFIEACLEHYNGNVERVINALLEG 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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