NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|528511867|ref|XP_005160819|]
View 

thrombospondin-1 isoform X1 [Danio rerio]

Protein Classification

LamG domain-containing protein( domain architecture ID 10430211)

LamG (Laminin G) domain-containing protein may serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules; similar to Oncorhynchus mykiss sex hormone-binding globulin beta form that may participate in the local control of ovarian functions in salmonids

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TSP_C pfam05735
Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and ...
 973-1170 9.72e-120

Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and related proteins.


:

Pssm-ID: 461725  Cd Length: 198  Bit Score: 367.73  E-value: 9.72e-120
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511867   973 QIDPNWVVRHQGKELVQTVNCDPGIAVGFDEFNSVDFSGTFFINTERDDDYAGFVFGYQSSSRFYVVMWKQITQTYWSST 1052
Cdd:pfam05735    1 QIDPIWVIRNQGREIQQTDNSDPGLAIGFDRFGSVDFSGTFFVNTDDDDDYIGFVFGYQSNSKFYVVMWKQVNQSYWPFK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511867  1053 PTKAQGYSGLSIKVVNSTTGPGEHLRNALWHTGDTPGQVRTLWHDPKNVGWKDFTAYRWHLTHRPRTGHIRVVMYEGKKI 1132
Cdd:pfam05735   81 PFRATGLKGIQLKVVKSTTGPGENLRNALWHTGDTTNQVRLLWHDPTWRGWKDRTAYRWHLQHRPSIGLIRVRVYEGITL 160

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 528511867  1133 MADSGRIYDKTYAGGRLGLFVFSQEMVYFSDLKYECRD 1170
Cdd:pfam05735  161 LADSGNVYDTTIRGGRLGVFCFSQENVIWSDLKYKCLD 198
LamG super family cl22861
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 25-220 7.53e-32

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


The actual alignment was detected with superfamily member smart00210:

Pssm-ID: 473984  Cd Length: 184  Bit Score: 122.85  E-value: 7.53e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511867     25 DDNSVYDLFELvqvprkNHGVTLVKGDDPYSPAYKILNPdliPPVPESAfRDLIDSIHAEkGFLLLVNFKQFKRTRGSLL 104
Cdd:smart00210    3 DLLQVFDLPSL------SFAIRQVVGPEPGSPAYRLGDP---ALVPQPT-RDLFPSGLPE-DFSLLTTFRQTPKSRGVLF 71

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511867    105 TVEKNDGSgPVFEIVSNGKANTLDIVFSTEN-KQQVVSIEEADLAVGHWKNITLFVQEDRVQFYVGCEEVNVAELDASIH 183
Cdd:smart00210   72 AIYDAQNV-RQFGLEVDGRANTLLLRYQGVDgKQHTVSFRNLPLADGQWHKLALSVSGSSATLYVDCNEIDSRPLDRPGQ 150

                           170       180       190
                    ....*....|....*....|....*....|....*..
gi 528511867    184 TilTQEIPGVAkMRIGKGAVKDRFMGVLQNVRFVFGT 220
Cdd:smart00210  151 P--PIDTDGIE-VRGAQAADRKPFQGDLQQLKIVCDP 184
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 496-548 2.61e-17

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 76.86  E-value: 2.61e-17
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 528511867    496 WGPWSPWDTCSVTCGGGVQNRKRLCNNPVPKHGGKECVGDAKVSQICNKQACP 548
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 318-372 1.80e-16

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


:

Pssm-ID: 278520  Cd Length: 57  Bit Score: 74.38  E-value: 1.80e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 528511867   318 CLHNGIVHKNKEEWTVDDCTECTCQNSATVCRKISCPLIPCANAT--VPDGECCPRC 372
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRleIPPGECCPVC 57
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 383-430 2.37e-13

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 65.69  E-value: 2.37e-13
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 528511867    383 WSPWSEWTHCSVSCGRGIQQRGRSCDRINNN-----CEGTSVQTRDCYLQECD 430
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQngggpCTGEDVETRACNEQPCP 53
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 847-883 1.55e-09

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


:

Pssm-ID: 367074  Cd Length: 36  Bit Score: 54.29  E-value: 1.55e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 528511867   847 DSDSDRVGDKCDsnQDIDEDGHQNNLDNCPYIPNANQ 883
Cdd:pfam02412    2 DSDSDGVGDACD--NDFDNDGVPDLLDNCPNNANIDQ 36
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 787-822 1.18e-08

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


:

Pssm-ID: 367074  Cd Length: 36  Bit Score: 51.60  E-value: 1.18e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 528511867   787 TDTDNNGEGDACAVDIDGDGILNEKDNCPYLYNVDQ 822
Cdd:pfam02412    1 TDSDSDGVGDACDNDFDNDGVPDLLDNCPNNANIDQ 36
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 448-491 1.85e-07

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 48.74  E-value: 1.85e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 528511867    448 CSVTCGAGVITRIRLCNSPTPQMDGKDCQGEGRQTERCEKSPCP 491
Cdd:smart00209   10 CSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 921-950 3.54e-07

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


:

Pssm-ID: 367074  Cd Length: 36  Bit Score: 47.36  E-value: 3.54e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 528511867   921 DSDGDGRGDACKDDFDMDNVLDIYDVCPEN 950
Cdd:pfam02412    2 DSDSDGVGDACDNDFDNDGVPDLLDNCPNN 31
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 651-690 6.36e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 43.74  E-value: 6.36e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 528511867   651 CLDGSHDCNKNARCNYlghfSDPMFRCECKPGFAGNGHIC 690
Cdd:pfam12947    1 CSDNNGGCHPNATCTN----TGGSFTCTCNDGYTGDGVTC 36
 
Name Accession Description Interval E-value
TSP_C pfam05735
Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and ...
 973-1170 9.72e-120

Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and related proteins.


Pssm-ID: 461725  Cd Length: 198  Bit Score: 367.73  E-value: 9.72e-120
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511867   973 QIDPNWVVRHQGKELVQTVNCDPGIAVGFDEFNSVDFSGTFFINTERDDDYAGFVFGYQSSSRFYVVMWKQITQTYWSST 1052
Cdd:pfam05735    1 QIDPIWVIRNQGREIQQTDNSDPGLAIGFDRFGSVDFSGTFFVNTDDDDDYIGFVFGYQSNSKFYVVMWKQVNQSYWPFK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511867  1053 PTKAQGYSGLSIKVVNSTTGPGEHLRNALWHTGDTPGQVRTLWHDPKNVGWKDFTAYRWHLTHRPRTGHIRVVMYEGKKI 1132
Cdd:pfam05735   81 PFRATGLKGIQLKVVKSTTGPGENLRNALWHTGDTTNQVRLLWHDPTWRGWKDRTAYRWHLQHRPSIGLIRVRVYEGITL 160

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 528511867  1133 MADSGRIYDKTYAGGRLGLFVFSQEMVYFSDLKYECRD 1170
Cdd:pfam05735  161 LADSGNVYDTTIRGGRLGVFCFSQENVIWSDLKYKCLD 198
TSPN smart00210
Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of ...
 25-220 7.53e-32

Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of thrombospondin


Pssm-ID: 214560  Cd Length: 184  Bit Score: 122.85  E-value: 7.53e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511867     25 DDNSVYDLFELvqvprkNHGVTLVKGDDPYSPAYKILNPdliPPVPESAfRDLIDSIHAEkGFLLLVNFKQFKRTRGSLL 104
Cdd:smart00210    3 DLLQVFDLPSL------SFAIRQVVGPEPGSPAYRLGDP---ALVPQPT-RDLFPSGLPE-DFSLLTTFRQTPKSRGVLF 71

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511867    105 TVEKNDGSgPVFEIVSNGKANTLDIVFSTEN-KQQVVSIEEADLAVGHWKNITLFVQEDRVQFYVGCEEVNVAELDASIH 183
Cdd:smart00210   72 AIYDAQNV-RQFGLEVDGRANTLLLRYQGVDgKQHTVSFRNLPLADGQWHKLALSVSGSSATLYVDCNEIDSRPLDRPGQ 150

                           170       180       190
                    ....*....|....*....|....*....|....*..
gi 528511867    184 TilTQEIPGVAkMRIGKGAVKDRFMGVLQNVRFVFGT 220
Cdd:smart00210  151 P--PIDTDGIE-VRGAQAADRKPFQGDLQQLKIVCDP 184
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 496-548 2.61e-17

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 76.86  E-value: 2.61e-17
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 528511867    496 WGPWSPWDTCSVTCGGGVQNRKRLCNNPVPKHGGKECVGDAKVSQICNKQACP 548
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 318-372 1.80e-16

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 74.38  E-value: 1.80e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 528511867   318 CLHNGIVHKNKEEWTVDDCTECTCQNSATVCRKISCPLIPCANAT--VPDGECCPRC 372
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRleIPPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
318-372 1.19e-13

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 66.39  E-value: 1.19e-13
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 528511867    318 CLHNGIVHKNKEEWTVDDCTECTCQNSATV-CRKISCPL-IPCANAT--VPDGECCPRC 372
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTVlCDPVECPPpPDCPNPErvKPPGECCPRC 59
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 383-430 2.37e-13

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 65.69  E-value: 2.37e-13
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 528511867    383 WSPWSEWTHCSVSCGRGIQQRGRSCDRINNN-----CEGTSVQTRDCYLQECD 430
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQngggpCTGEDVETRACNEQPCP 53
TSP_1 pfam00090
Thrombospondin type 1 domain;
497-547 4.24e-13

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 64.75  E-value: 4.24e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 528511867   497 GPWSPWDTCSVTCGGGVQNRKRLCNNPVPkhGGKECVGDAKVSQICNKQAC 547
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKMDKC 49
TSP_1 pfam00090
Thrombospondin type 1 domain;
384-429 3.91e-11

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 58.97  E-value: 3.91e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 528511867   384 SPWSEWTHCSVSCGRGIQQRGRSCD---RINNNCEGTSVQTRDCYLQEC 429
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKspfPGGEPCTGDDIETQACKMDKC 49
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 847-883 1.55e-09

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 54.29  E-value: 1.55e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 528511867   847 DSDSDRVGDKCDsnQDIDEDGHQNNLDNCPYIPNANQ 883
Cdd:pfam02412    2 DSDSDGVGDACD--NDFDNDGVPDLLDNCPNNANIDQ 36
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 787-822 1.18e-08

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 51.60  E-value: 1.18e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 528511867   787 TDTDNNGEGDACAVDIDGDGILNEKDNCPYLYNVDQ 822
Cdd:pfam02412    1 TDSDSDGVGDACDNDFDNDGVPDLLDNCPNNANIDQ 36
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 448-491 1.85e-07

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 48.74  E-value: 1.85e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 528511867    448 CSVTCGAGVITRIRLCNSPTPQMDGKDCQGEGRQTERCEKSPCP 491
Cdd:smart00209   10 CSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 921-950 3.54e-07

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 47.36  E-value: 3.54e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 528511867   921 DSDGDGRGDACKDDFDMDNVLDIYDVCPEN 950
Cdd:pfam02412    2 DSDSDGVGDACDNDFDNDGVPDLLDNCPNN 31
TSP_1 pfam00090
Thrombospondin type 1 domain;
448-490 5.60e-06

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 44.33  E-value: 5.60e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 528511867   448 CSVTCGAGVITRIRLCNSPTPqmDGKDCQGEGRQTERCEKSPC 490
Cdd:pfam00090    9 CSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKMDKC 49
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 651-690 6.36e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 43.74  E-value: 6.36e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 528511867   651 CLDGSHDCNKNARCNYlghfSDPMFRCECKPGFAGNGHIC 690
Cdd:pfam12947    1 CSDNNGGCHPNATCTN----TGGSFTCTCNDGYTGDGVTC 36
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 497-518 1.24e-03

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 43.03  E-value: 1.24e-03
                          10        20
                  ....*....|....*....|..
gi 528511867  497 GPWSPWDTCSVTCGGGVQNRKR 518
Cdd:PTZ00441  241 GPWDEWTPCSVTCGKGTHSRSR 262
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 385-429 1.74e-03

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 42.26  E-value: 1.74e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 528511867  385 PWSEWTHCSVSCGRGIQQRGRSCdrINNNCegTSVQTRDCYLQEC 429
Cdd:PTZ00441  242 PWDEWTPCSVTCGKGTHSRSRPI--LHEGC--TTHMVEECEEEEC 282
 
Name Accession Description Interval E-value
TSP_C pfam05735
Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and ...
 973-1170 9.72e-120

Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and related proteins.


Pssm-ID: 461725  Cd Length: 198  Bit Score: 367.73  E-value: 9.72e-120
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511867   973 QIDPNWVVRHQGKELVQTVNCDPGIAVGFDEFNSVDFSGTFFINTERDDDYAGFVFGYQSSSRFYVVMWKQITQTYWSST 1052
Cdd:pfam05735    1 QIDPIWVIRNQGREIQQTDNSDPGLAIGFDRFGSVDFSGTFFVNTDDDDDYIGFVFGYQSNSKFYVVMWKQVNQSYWPFK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511867  1053 PTKAQGYSGLSIKVVNSTTGPGEHLRNALWHTGDTPGQVRTLWHDPKNVGWKDFTAYRWHLTHRPRTGHIRVVMYEGKKI 1132
Cdd:pfam05735   81 PFRATGLKGIQLKVVKSTTGPGENLRNALWHTGDTTNQVRLLWHDPTWRGWKDRTAYRWHLQHRPSIGLIRVRVYEGITL 160

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 528511867  1133 MADSGRIYDKTYAGGRLGLFVFSQEMVYFSDLKYECRD 1170
Cdd:pfam05735  161 LADSGNVYDTTIRGGRLGVFCFSQENVIWSDLKYKCLD 198
TSPN smart00210
Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of ...
 25-220 7.53e-32

Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of thrombospondin


Pssm-ID: 214560  Cd Length: 184  Bit Score: 122.85  E-value: 7.53e-32
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511867     25 DDNSVYDLFELvqvprkNHGVTLVKGDDPYSPAYKILNPdliPPVPESAfRDLIDSIHAEkGFLLLVNFKQFKRTRGSLL 104
Cdd:smart00210    3 DLLQVFDLPSL------SFAIRQVVGPEPGSPAYRLGDP---ALVPQPT-RDLFPSGLPE-DFSLLTTFRQTPKSRGVLF 71

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528511867    105 TVEKNDGSgPVFEIVSNGKANTLDIVFSTEN-KQQVVSIEEADLAVGHWKNITLFVQEDRVQFYVGCEEVNVAELDASIH 183
Cdd:smart00210   72 AIYDAQNV-RQFGLEVDGRANTLLLRYQGVDgKQHTVSFRNLPLADGQWHKLALSVSGSSATLYVDCNEIDSRPLDRPGQ 150

                           170       180       190
                    ....*....|....*....|....*....|....*..
gi 528511867    184 TilTQEIPGVAkMRIGKGAVKDRFMGVLQNVRFVFGT 220
Cdd:smart00210  151 P--PIDTDGIE-VRGAQAADRKPFQGDLQQLKIVCDP 184
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 496-548 2.61e-17

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 76.86  E-value: 2.61e-17
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 528511867    496 WGPWSPWDTCSVTCGGGVQNRKRLCNNPVPKHGGKECVGDAKVSQICNKQACP 548
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 318-372 1.80e-16

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 74.38  E-value: 1.80e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 528511867   318 CLHNGIVHKNKEEWTVDDCTECTCQNSATVCRKISCPLIPCANAT--VPDGECCPRC 372
Cdd:pfam00093    1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRleIPPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
318-372 1.19e-13

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 66.39  E-value: 1.19e-13
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 528511867    318 CLHNGIVHKNKEEWTVDDCTECTCQNSATV-CRKISCPL-IPCANAT--VPDGECCPRC 372
Cdd:smart00214    1 CVHNGRVYNDGETWKPDPCQICTCLDGTTVlCDPVECPPpPDCPNPErvKPPGECCPRC 59
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 383-430 2.37e-13

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 65.69  E-value: 2.37e-13
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 528511867    383 WSPWSEWTHCSVSCGRGIQQRGRSCDRINNN-----CEGTSVQTRDCYLQECD 430
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQngggpCTGEDVETRACNEQPCP 53
TSP_1 pfam00090
Thrombospondin type 1 domain;
497-547 4.24e-13

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 64.75  E-value: 4.24e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 528511867   497 GPWSPWDTCSVTCGGGVQNRKRLCNNPVPkhGGKECVGDAKVSQICNKQAC 547
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKMDKC 49
TSP_1 pfam00090
Thrombospondin type 1 domain;
384-429 3.91e-11

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 58.97  E-value: 3.91e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 528511867   384 SPWSEWTHCSVSCGRGIQQRGRSCD---RINNNCEGTSVQTRDCYLQEC 429
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKspfPGGEPCTGDDIETQACKMDKC 49
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 847-883 1.55e-09

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 54.29  E-value: 1.55e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 528511867   847 DSDSDRVGDKCDsnQDIDEDGHQNNLDNCPYIPNANQ 883
Cdd:pfam02412    2 DSDSDGVGDACD--NDFDNDGVPDLLDNCPNNANIDQ 36
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 787-822 1.18e-08

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 51.60  E-value: 1.18e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 528511867   787 TDTDNNGEGDACAVDIDGDGILNEKDNCPYLYNVDQ 822
Cdd:pfam02412    1 TDSDSDGVGDACDNDFDNDGVPDLLDNCPNNANIDQ 36
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 497-547 3.20e-08

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 50.74  E-value: 3.20e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 528511867   497 GPWSPWDTCSVTCGGGVQNRKRLCNNPvPKHGGKECVGDAKvSQICNKQAC 547
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTRTVIVE-PQNGGRPCPELLE-RRPCNLPPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 448-491 1.85e-07

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 48.74  E-value: 1.85e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 528511867    448 CSVTCGAGVITRIRLCNSPTPQMDGKDCQGEGRQTERCEKSPCP 491
Cdd:smart00209   10 CSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 921-950 3.54e-07

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 47.36  E-value: 3.54e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 528511867   921 DSDGDGRGDACKDDFDMDNVLDIYDVCPEN 950
Cdd:pfam02412    2 DSDSDGVGDACDNDFDNDGVPDLLDNCPNN 31
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 384-429 5.23e-07

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 47.27  E-value: 5.23e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 528511867   384 SPWSEWTHCSVSCGRGIQQR-----------GRSCdrinnnceGTSVQTRDCYLQEC 429
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRtrtvivepqngGRPC--------PELLERRPCNLPPC 52
TSP_1 pfam00090
Thrombospondin type 1 domain;
448-490 5.60e-06

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 44.33  E-value: 5.60e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 528511867   448 CSVTCGAGVITRIRLCNSPTPqmDGKDCQGEGRQTERCEKSPC 490
Cdd:pfam00090    9 CSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKMDKC 49
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 651-690 6.36e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 43.74  E-value: 6.36e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 528511867   651 CLDGSHDCNKNARCNYlghfSDPMFRCECKPGFAGNGHIC 690
Cdd:pfam12947    1 CSDNNGGCHPNATCTN----TGGSFTCTCNDGYTGDGVTC 36
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 497-547 9.51e-06

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 43.98  E-value: 9.51e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 528511867   497 GPWSPwdtCSVTCGGGVQNRKRLCNNPVPK--HGGKECVGDAK--VSQICNKQAC 547
Cdd:pfam19030    4 GPWGE---CSVTCGGGVQTRLVQCVQKGGGsiVPDSECSAQKKppETQSCNLKPC 55
Amnionless pfam14828
Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for ...
 335-381 7.98e-04

Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake.


Pssm-ID: 464340  Cd Length: 449  Bit Score: 43.53  E-value: 7.98e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 528511867   335 DCTECTCQNSAT---VCRKIS--CPLIPCANATVPDGECCPRCG----TPSDSAED 381
Cdd:pfam14828  193 DPSGCGCGNDENlerICANVLqrCPPPHCLSPLRPEGHCCDVCGaivsLDYSSCFD 248
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 497-518 1.24e-03

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 43.03  E-value: 1.24e-03
                          10        20
                  ....*....|....*....|..
gi 528511867  497 GPWSPWDTCSVTCGGGVQNRKR 518
Cdd:PTZ00441  241 GPWDEWTPCSVTCGKGTHSRSR 262
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 385-429 1.74e-03

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 42.26  E-value: 1.74e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 528511867  385 PWSEWTHCSVSCGRGIQQRGRSCdrINNNCegTSVQTRDCYLQEC 429
Cdd:PTZ00441  242 PWDEWTPCSVTCGKGTHSRSRPI--LHEGC--TTHMVEECEEEEC 282
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
 387-429 5.73e-03

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


Pssm-ID: 465952  Cd Length: 44  Bit Score: 35.77  E-value: 5.73e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 528511867   387 SEWTHCSVSCGRGIQQRgrscdRINNNCEGTSV-QTRDCYLQEC 429
Cdd:pfam19035    6 TEWSPCSKTCGMGVSTR-----VSNDNAECKLVtETRLCQLRPC 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH