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Conserved domains on  [gi|530378898|ref|XP_005248399|]
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excitatory amino acid transporter 1 isoform X1 [Homo sapiens]

Protein Classification

dicarboxylate/amino acid:cation symporter( domain architecture ID 10003465)

dicarboxylate/amino acid:cation symporter facilitates H+ or Na+ symport with C4-dicarboxylates, dicarboxylic amino acids (aspartate, glutamate) or other amino acids; belongs to the sodium:dicarboxylate symporter family

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
GltP COG1301
Na+/H+-dicarboxylate symporter [Energy production and conversion];
46-496 2.96e-118

Na+/H+-dicarboxylate symporter [Energy production and conversion];


:

Pssm-ID: 440912 [Multi-domain]  Cd Length: 406  Bit Score: 354.80  E-value: 2.96e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898  46 FRNAFVLLTVTAVIVGTILGFTLRPYrmsyrEVKYFSFPGELLMRMLQMLVLPLIISSLVTGMAAL-DSKASGKMGMRAV 124
Cdd:COG1301    1 FKLSLTLQILIALVLGILLGLLLPEL-----VAAVLKPLGDIFINLLKMIVVPLVFFSIVVGIASLgDLKKLGRIGGKTL 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898 125 VYYMTTTIIAVVIGIIIVIIIHPGKGTKENMHREGKIVRVTAADaFLDLIRNMFPPNLVEAcfkqfktnyekrsfkvpiq 204
Cdd:COG1301   76 LYFLVTTTIALVIGLVVANLFQPGAGLNLDLADAAAAEAAEAPS-LLDFLLNIIPSNIFEA------------------- 135
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898 205 anetlvgavinnvseametltriteelvpvpgSVNGvNALGLVVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMRLVAV 284
Cdd:COG1301  136 --------------------------------FAEG-NMLQIIFFAILFGIALAALGEKGKPLLDFFESLSEVMFKIVGW 182
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898 285 IMWYAPVGILFLIAGKIVEMeDMGVIGgQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIGGLLQALITALGTSS 364
Cdd:COG1301  183 VMKLAPIGVFALIAATVAKY-GLDALG-SLGKLVLTVYLALLLHLFVVLPLILRLLTGLSPLKFLRAIRPALLLAFSTSS 260
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898 365 SSATLPITFKCLEENNGVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQVNNFELNFGQIITISITATAASIGAAGIP 444
Cdd:COG1301  261 SEATLPVTMEKAEEKLGVSKSVASFVLPLGATINMDGTAIYQAVAALFIAQAYGIDLSLGQQLTIVLTAVLASIGAAGVP 340
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|..
gi 530378898 445 QAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRTTTNVLGDSLGAGIVEH 496
Cdd:COG1301  341 GAGLVMLAAVLSAVGLPLEGIALILGIDRILDMARTAVNVTGDAVATVVVAK 392
 
Name Accession Description Interval E-value
GltP COG1301
Na+/H+-dicarboxylate symporter [Energy production and conversion];
46-496 2.96e-118

Na+/H+-dicarboxylate symporter [Energy production and conversion];


Pssm-ID: 440912 [Multi-domain]  Cd Length: 406  Bit Score: 354.80  E-value: 2.96e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898  46 FRNAFVLLTVTAVIVGTILGFTLRPYrmsyrEVKYFSFPGELLMRMLQMLVLPLIISSLVTGMAAL-DSKASGKMGMRAV 124
Cdd:COG1301    1 FKLSLTLQILIALVLGILLGLLLPEL-----VAAVLKPLGDIFINLLKMIVVPLVFFSIVVGIASLgDLKKLGRIGGKTL 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898 125 VYYMTTTIIAVVIGIIIVIIIHPGKGTKENMHREGKIVRVTAADaFLDLIRNMFPPNLVEAcfkqfktnyekrsfkvpiq 204
Cdd:COG1301   76 LYFLVTTTIALVIGLVVANLFQPGAGLNLDLADAAAAEAAEAPS-LLDFLLNIIPSNIFEA------------------- 135
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898 205 anetlvgavinnvseametltriteelvpvpgSVNGvNALGLVVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMRLVAV 284
Cdd:COG1301  136 --------------------------------FAEG-NMLQIIFFAILFGIALAALGEKGKPLLDFFESLSEVMFKIVGW 182
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898 285 IMWYAPVGILFLIAGKIVEMeDMGVIGgQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIGGLLQALITALGTSS 364
Cdd:COG1301  183 VMKLAPIGVFALIAATVAKY-GLDALG-SLGKLVLTVYLALLLHLFVVLPLILRLLTGLSPLKFLRAIRPALLLAFSTSS 260
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898 365 SSATLPITFKCLEENNGVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQVNNFELNFGQIITISITATAASIGAAGIP 444
Cdd:COG1301  261 SEATLPVTMEKAEEKLGVSKSVASFVLPLGATINMDGTAIYQAVAALFIAQAYGIDLSLGQQLTIVLTAVLASIGAAGVP 340
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|..
gi 530378898 445 QAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRTTTNVLGDSLGAGIVEH 496
Cdd:COG1301  341 GAGLVMLAAVLSAVGLPLEGIALILGIDRILDMARTAVNVTGDAVATVVVAK 392
SDF pfam00375
Sodium:dicarboxylate symporter family;
50-497 4.30e-114

Sodium:dicarboxylate symporter family;


Pssm-ID: 425646 [Multi-domain]  Cd Length: 388  Bit Score: 343.73  E-value: 4.30e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898   50 FVLLTVTAVIVGTILGFTLRPYRMsyrevkYFSFPGELLMRMLQMLVLPLIISSLVTGMAAL-DSKASGKMGMRAVVYYM 128
Cdd:pfam00375   1 LLLQILIALVLGILIGLFFPELAA------WLKPLGDLFIRLLKMIIVPLIFASIISGIASLgDGKKLGKLGGKTLLYFL 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898  129 TTTIIAVVIGIIIVIIIHPGKGTKeNMHREGKIVRVTAADAFLDLIRNMFPPNLVEACFKQfktnyekrsfkvpiqanet 208
Cdd:pfam00375  75 VTTAIAALIGLLVANVFQPGSGLA-LIAASLKEAKAAEAPSLLDFILNIIPSNIFEALAEG------------------- 134
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898  209 lvgavinnvseametltriteelvpvpgsvngvNALGLVVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMRLVAVIMWY 288
Cdd:pfam00375 135 ---------------------------------NVLAVIVFAILFGIALAALGEKGEPLLNFIESLQEVMMKVIGWVMKL 181
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898  289 APVGILFLIAGKIVEmEDMGVIGgQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIGGLLQALITALGTSSSSAT 368
Cdd:pfam00375 182 APIGVFALIANTVGT-YGLGILS-SLAKFLLVVYLGLAIHLLIVYPLLIKFLGKVNPFKFLKKMLPALLTAFSTASSAAT 259
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898  369 LPITFKCLEENNGVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQVNNFELNFGQIITISITATAASIGAAGIPQAGL 448
Cdd:pfam00375 260 LPVTLECAEKNLGVSESIASFVLPLGATINMDGTAIYLAVAAIFIAQAYGVDLSFGQQLTLVLTATLASIGAAGVPGGGL 339
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 530378898  449 VTMVIVLTSVGLPTDDITLIIAVDWFLDRLRTTTNVLGDSLGAGIVEHL 497
Cdd:pfam00375 340 VALGLVLSALGLPLEGIALILAIDRLLDMFRTAVNVTGDAAAAVIVAKL 388
gltP PRK11283
glutamate/aspartate:proton symporter; Provisional
57-489 5.20e-37

glutamate/aspartate:proton symporter; Provisional


Pssm-ID: 183075 [Multi-domain]  Cd Length: 437  Bit Score: 142.21  E-value: 5.20e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898  57 AVIVGTILGFTLRpYRMSYRE---VKYFSFPGELLMRMLQMLVLPLIISSLVTGMAAL-DSKASGKMGMRAVVYYMTTTI 132
Cdd:PRK11283  15 ALVLGILLGAYLH-YHSDSRDwlvSNLLSPAGDIFIHLIKMIVVPIVISTLIVGIAGVgDAKQLGRIGAKTIIYFEVITT 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898 133 IAVVIGIIIVIIIHPGKGTKENMhregkivrVTAADAfldlirnmfppnlveacfkqfkTNYEKRSFKVPIQAN---ETL 209
Cdd:PRK11283  94 VAIILGITLANVFQPGAGIDMSQ--------LATVDI----------------------SKYQSTTEEVQSHSHglmGTI 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898 210 VGAVINNVSEAMETltritEELVPVpgsvngvnalglVVFSMCFGFVIGNM-KEQGQALREFFDSLNEAIMRLVAVIMWY 288
Cdd:PRK11283 144 LSLIPTNIFASMAK-----GEMLPI------------IFFSVLFGLGLSSLpATHREPLVTVFRSVSETMFKVTHMVMRY 206
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898 289 APVGILFLIAGKIVEMEDMGVIggQLAMYTVTVIVGLLIHAVIVLPLLYFLVtRKNPWVFIGGLLQALITALGTSSSSAT 368
Cdd:PRK11283 207 APVGVFALIAVTVANFGFASLW--PLAKLVLLVYFAILFFALVVLGIVARLC-GLSIWILIRILKDELILAYSTASSETV 283
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898 369 LPITFKCLEENnGVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQVNNFELNFGQIITISITATAASIGAAGIPQAGL 448
Cdd:PRK11283 284 LPRIIEKMEAY-GAPKSITSFVVPTGYSFNLDGSTLYQSIAAIFIAQLYGIDLSIWQEIILVLTLMVTSKGIAGVPGVSF 362
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
gi 530378898 449 VTMVIVLTSVGLPTDDITLIIAVDWFLDRLRTTTNVLGDSL 489
Cdd:PRK11283 363 VVLLATLGSVGIPLEGLAFIAGVDRILDMARTALNVVGNAL 403
 
Name Accession Description Interval E-value
GltP COG1301
Na+/H+-dicarboxylate symporter [Energy production and conversion];
46-496 2.96e-118

Na+/H+-dicarboxylate symporter [Energy production and conversion];


Pssm-ID: 440912 [Multi-domain]  Cd Length: 406  Bit Score: 354.80  E-value: 2.96e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898  46 FRNAFVLLTVTAVIVGTILGFTLRPYrmsyrEVKYFSFPGELLMRMLQMLVLPLIISSLVTGMAAL-DSKASGKMGMRAV 124
Cdd:COG1301    1 FKLSLTLQILIALVLGILLGLLLPEL-----VAAVLKPLGDIFINLLKMIVVPLVFFSIVVGIASLgDLKKLGRIGGKTL 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898 125 VYYMTTTIIAVVIGIIIVIIIHPGKGTKENMHREGKIVRVTAADaFLDLIRNMFPPNLVEAcfkqfktnyekrsfkvpiq 204
Cdd:COG1301   76 LYFLVTTTIALVIGLVVANLFQPGAGLNLDLADAAAAEAAEAPS-LLDFLLNIIPSNIFEA------------------- 135
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898 205 anetlvgavinnvseametltriteelvpvpgSVNGvNALGLVVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMRLVAV 284
Cdd:COG1301  136 --------------------------------FAEG-NMLQIIFFAILFGIALAALGEKGKPLLDFFESLSEVMFKIVGW 182
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898 285 IMWYAPVGILFLIAGKIVEMeDMGVIGgQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIGGLLQALITALGTSS 364
Cdd:COG1301  183 VMKLAPIGVFALIAATVAKY-GLDALG-SLGKLVLTVYLALLLHLFVVLPLILRLLTGLSPLKFLRAIRPALLLAFSTSS 260
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898 365 SSATLPITFKCLEENNGVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQVNNFELNFGQIITISITATAASIGAAGIP 444
Cdd:COG1301  261 SEATLPVTMEKAEEKLGVSKSVASFVLPLGATINMDGTAIYQAVAALFIAQAYGIDLSLGQQLTIVLTAVLASIGAAGVP 340
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|..
gi 530378898 445 QAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRTTTNVLGDSLGAGIVEH 496
Cdd:COG1301  341 GAGLVMLAAVLSAVGLPLEGIALILGIDRILDMARTAVNVTGDAVATVVVAK 392
SDF pfam00375
Sodium:dicarboxylate symporter family;
50-497 4.30e-114

Sodium:dicarboxylate symporter family;


Pssm-ID: 425646 [Multi-domain]  Cd Length: 388  Bit Score: 343.73  E-value: 4.30e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898   50 FVLLTVTAVIVGTILGFTLRPYRMsyrevkYFSFPGELLMRMLQMLVLPLIISSLVTGMAAL-DSKASGKMGMRAVVYYM 128
Cdd:pfam00375   1 LLLQILIALVLGILIGLFFPELAA------WLKPLGDLFIRLLKMIIVPLIFASIISGIASLgDGKKLGKLGGKTLLYFL 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898  129 TTTIIAVVIGIIIVIIIHPGKGTKeNMHREGKIVRVTAADAFLDLIRNMFPPNLVEACFKQfktnyekrsfkvpiqanet 208
Cdd:pfam00375  75 VTTAIAALIGLLVANVFQPGSGLA-LIAASLKEAKAAEAPSLLDFILNIIPSNIFEALAEG------------------- 134
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898  209 lvgavinnvseametltriteelvpvpgsvngvNALGLVVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMRLVAVIMWY 288
Cdd:pfam00375 135 ---------------------------------NVLAVIVFAILFGIALAALGEKGEPLLNFIESLQEVMMKVIGWVMKL 181
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898  289 APVGILFLIAGKIVEmEDMGVIGgQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIGGLLQALITALGTSSSSAT 368
Cdd:pfam00375 182 APIGVFALIANTVGT-YGLGILS-SLAKFLLVVYLGLAIHLLIVYPLLIKFLGKVNPFKFLKKMLPALLTAFSTASSAAT 259
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898  369 LPITFKCLEENNGVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQVNNFELNFGQIITISITATAASIGAAGIPQAGL 448
Cdd:pfam00375 260 LPVTLECAEKNLGVSESIASFVLPLGATINMDGTAIYLAVAAIFIAQAYGVDLSFGQQLTLVLTATLASIGAAGVPGGGL 339
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 530378898  449 VTMVIVLTSVGLPTDDITLIIAVDWFLDRLRTTTNVLGDSLGAGIVEHL 497
Cdd:pfam00375 340 VALGLVLSALGLPLEGIALILAIDRLLDMFRTAVNVTGDAAAAVIVAKL 388
gltP PRK11283
glutamate/aspartate:proton symporter; Provisional
57-489 5.20e-37

glutamate/aspartate:proton symporter; Provisional


Pssm-ID: 183075 [Multi-domain]  Cd Length: 437  Bit Score: 142.21  E-value: 5.20e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898  57 AVIVGTILGFTLRpYRMSYRE---VKYFSFPGELLMRMLQMLVLPLIISSLVTGMAAL-DSKASGKMGMRAVVYYMTTTI 132
Cdd:PRK11283  15 ALVLGILLGAYLH-YHSDSRDwlvSNLLSPAGDIFIHLIKMIVVPIVISTLIVGIAGVgDAKQLGRIGAKTIIYFEVITT 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898 133 IAVVIGIIIVIIIHPGKGTKENMhregkivrVTAADAfldlirnmfppnlveacfkqfkTNYEKRSFKVPIQAN---ETL 209
Cdd:PRK11283  94 VAIILGITLANVFQPGAGIDMSQ--------LATVDI----------------------SKYQSTTEEVQSHSHglmGTI 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898 210 VGAVINNVSEAMETltritEELVPVpgsvngvnalglVVFSMCFGFVIGNM-KEQGQALREFFDSLNEAIMRLVAVIMWY 288
Cdd:PRK11283 144 LSLIPTNIFASMAK-----GEMLPI------------IFFSVLFGLGLSSLpATHREPLVTVFRSVSETMFKVTHMVMRY 206
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898 289 APVGILFLIAGKIVEMEDMGVIggQLAMYTVTVIVGLLIHAVIVLPLLYFLVtRKNPWVFIGGLLQALITALGTSSSSAT 368
Cdd:PRK11283 207 APVGVFALIAVTVANFGFASLW--PLAKLVLLVYFAILFFALVVLGIVARLC-GLSIWILIRILKDELILAYSTASSETV 283
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898 369 LPITFKCLEENnGVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQVNNFELNFGQIITISITATAASIGAAGIPQAGL 448
Cdd:PRK11283 284 LPRIIEKMEAY-GAPKSITSFVVPTGYSFNLDGSTLYQSIAAIFIAQLYGIDLSIWQEIILVLTLMVTSKGIAGVPGVSF 362
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
gi 530378898 449 VTMVIVLTSVGLPTDDITLIIAVDWFLDRLRTTTNVLGDSL 489
Cdd:PRK11283 363 VVLLATLGSVGIPLEGLAFIAGVDRILDMARTALNVVGNAL 403
PRK01663 PRK01663
C4-dicarboxylate transporter DctA; Reviewed
42-486 7.18e-34

C4-dicarboxylate transporter DctA; Reviewed


Pssm-ID: 234968 [Multi-domain]  Cd Length: 428  Bit Score: 133.10  E-value: 7.18e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898  42 KSYLFRNAFVLLtVTAVIVGTILGF-------TLRPYrmsyrevkyfsfpGELLMRMLQMLVLPLIISSLVTGMAAL-DS 113
Cdd:PRK01663   2 KKPLYKSLYFQV-LVAIIIGILLGHfypelgaQMKPL-------------GDGFIKLIKMIIAPIIFCTVVTGIAGMgDM 67
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898 114 KASGKMGMRAVVYYMTTTIIAVVIGIIIVIIIHPGKGtkenMHR-----EGKIVRVTAADA----FLDLIRNMFPPNLVE 184
Cdd:PRK01663  68 KKVGRVGGKALLYFEIVSTIALIIGLIVVNVVQPGAG----MNIdpatlDAKAVAQYAAQAheqgTVDFLMDIIPTTVVG 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898 185 AcfkqFKTNyekrsfkvpiqanetlvgavinnvseametltriteelvpvpgsvngvNALGLVVFSMCFGFVIGNMKEQG 264
Cdd:PRK01663 144 A----FASG------------------------------------------------DILQVLLFAVLFGFALARLGEKG 171
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898 265 QALREFFDSLNEAIMRLVAVIMWYAPVGILFLIAGKIvemedmGVIG----GQLAMYTVTVIVGLLIHAVIVLPLlyflV 340
Cdd:PRK01663 172 KPVFDFIESLSHVLFGIVNMIMKLAPIGAFGAMAFTI------GKYGvgslVQLGQLIGCFYITCILFVFVVLGA----I 241
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898 341 TRK---NPWVFIGGLLQALITALGTSSSSATLPITFKCLEeNNGVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQVN 417
Cdd:PRK01663 242 ARLtgfSIFKFIRYIKEELLIVLGTSSSESALPRMMEKME-KLGCKKSVVGLVIPTGYSFNLDGTSIYLTMAAVFIAQAT 320
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898 418 NFELNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVG-LPTDDITLIIAVDWFLDRLRTTTNVLG 486
Cdd:PRK01663 321 NTPLSIGHQITLLAVLLLTSKGAAGVTGSGFIVLAATLSAVPhIPVAGLALILGIDRFMSEARALTNLIG 390
PRK13027 PRK13027
C4-dicarboxylate transporter DctA; Reviewed
42-487 2.34e-33

C4-dicarboxylate transporter DctA; Reviewed


Pssm-ID: 183850 [Multi-domain]  Cd Length: 421  Bit Score: 131.71  E-value: 2.34e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898  42 KSYLFRNAFVLLtVTAVIVGTILGFTLRPYRMSYREVkyfsfpGELLMRMLQMLVLPLIISSLVTGMA-ALDSKASGKMG 120
Cdd:PRK13027   1 MKKFLRSLFGQV-VIALVLGVALGAFFPHFAESLKPL------GDGFIKLIKMLIGPIVFCVVVSGIAgAGDLKKVGRVG 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898 121 MRAVVYYMTTTIIAVVIGIIIVIIIHPGKGTKENMH-----------REGKIVRVTAaDAFLDLIRNmfppnlveacfkq 189
Cdd:PRK13027  74 LKAVIYFEVMTTIALVIGLVLAYLTGPGVGMNIDLRsldaaslagyaKNAQSLKGTA-GFLLKLIPT------------- 139
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898 190 fktnyekrsfkvpiqaneTLVGAVINNvseametltriteelvpvpgsvngvNALGLVVFSMCFGFVIGNMKEQGQALRE 269
Cdd:PRK13027 140 ------------------TAVDAFAKG-------------------------DILQVLLFSVLFGSALSLLGERAKRVNR 176
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898 270 FFDSLNEAIMRLVAVIMWYAPVGILFLIA---GK--IVEMEDMGVIggqLAMYTVTVIVGLLIHAVIVLPLLYFLVtrkn 344
Cdd:PRK13027 177 LIDELSHVLFRIMGFIIKLAPLGVLGAIAfttGKygVGSLKQLGML---VAVFYLTCFVFVVVVLGAVMRLAGFSV---- 249
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898 345 pWVFIGGLLQALITALGTSSSSATLPITFKCLEeNNGVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQVNNFELNFG 424
Cdd:PRK13027 250 -FKLIRYLREELLIVLGTASSDAVLPQVMRKLE-HMGIKDSTVGLVIPTGYSFNLDGFSIYLTLAAVFIAQATNTPLSMH 327
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530378898 425 QIITISITATAASIGAAGIPQAGLVTMVIVLTSVG-LPTDDITLIIAVDWFLDRLRTTTNVLGD 487
Cdd:PRK13027 328 DLITILLVSLVTSKGAHGIPGSAIVILAATLSAIPaIPVLGLVLILPVDWFMGIARALTNLIGN 391
TcyP COG1823
L-cystine transporter TcyP, sodium:dicarboxylate symporter family [Amino acid transport and ...
56-494 1.10e-19

L-cystine transporter TcyP, sodium:dicarboxylate symporter family [Amino acid transport and metabolism];


Pssm-ID: 441428  Cd Length: 463  Bit Score: 91.81  E-value: 1.10e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898  56 TAVIVGTILGFTLR-PYRMSYREVK----YFSFPGELLMRMLQMLVLPLIISSLVTGMAALDSKAS-GKMGMRAVVYYMT 129
Cdd:COG1823   36 TGLGLGILFGLILQlIYGAGSPVIKqsidWFNIVGNGYVRLLQMIVMPLVFVSILSAITKLKNASSlGKISGLIIGILLG 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898 130 TTIIAVvigiiiviiihpgkgtkenmhregkIVRVTAADAFldlirnmfppNLVEACFKQfktnyekrsfkvpiQANETL 209
Cdd:COG1823  116 TTAIAA-------------------------LVGILVALLF----------GLTAEGLTQ--------------GAAETA 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898 210 VGAVINNVSEAMETLTrITEELVP-VPGSV----NGVNA---LGLVVFSMCFGF-VIGNMK---EQGQALREFFDSLNEA 277
Cdd:COG1823  147 RGEALEERLGEVEDLS-LPQQILSfIPTNPfadlTGARPtstIAVVIFAAFLGIaALGLRRkkpEQAETFLKGIDALQAI 225
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898 278 IMRLVAVIMWYAPVGILFLIAgKIVEMEDMGVI----GGQLAMYtVTVIVGLLIHAVIVlpllyfLVTRKNPWVFIGGLL 353
Cdd:COG1823  226 VMRLVRLVLRLTPYGVLALMT-KVVATSDFADIlnlgKFVVASY-VALIIMFIVHLLLL------ALAGLNPLTYFKKVW 297
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898 354 QALITALGTSSSSATLPITFKCLEENNGVDKRVTRFVLPVGATINMDGTA-LYEALAAIFIAQ---VNNFELNFgqIITI 429
Cdd:COG1823  298 PVLTFAFTSRSSAGTIPLNIETQTKRLGVPEGIANFAASFGATIGQNGCAgIYPAMLAVMIAPtvgINPLDPSF--ILTL 375
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530378898 430 SITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRTTTNVlGDSLGAGIV 494
Cdd:COG1823  376 IAVVTISSFGVAGVGGGATFAALIVLSAMGLPVALAGLLISIEPLIDMGRTALNV-SGSMTAGTV 439
PRK14695 PRK14695
serine/threonine transporter SstT; Provisional
198-496 2.06e-16

serine/threonine transporter SstT; Provisional


Pssm-ID: 173158  Cd Length: 319  Bit Score: 80.48  E-value: 2.06e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898 198 SFKVPIQANETLVGAVINNVSEAMETLTRITEELVPVP-GSVNGVNALGLVVFSMCFGFVignMKEQGQALREFFDSLNE 276
Cdd:PRK14695  15 SFIVPIEITLNSANTEIAPPDGIGQVLSNLLLKLVDSPvNALLTANYIGILSWAVIFGIA---MREASKNSKELLKTIAD 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898 277 AIMRLVAVIMWYAPVGILFLIAGKIvemEDMGVigGQLAMY---TVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIGGLL 353
Cdd:PRK14695  92 VTSKIVEWIINLAPFGILGLVFKTI---SDKGV--GSLANYgilLVLLVTTMLFVAPVVNPLIAFFFMRRNPYPLVWNCL 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898 354 Q-ALITALGTSSSSATLPITFKcLEENNGVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQVNNFELNFGQIITISIT 432
Cdd:PRK14695 167 RvSGVTAFFTRSSATNIPVNMK-LCHDLGLNPDTYSVSIPLGSTINMAGVAITINLLTLVTVNTLGIPVDFATAFVLSVV 245
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530378898 433 ATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFL----DRLRTTTNVLGDSLGAGIVEH 496
Cdd:PRK14695 246 AAISACGASGIAGGSLLLIPVACSLFGISNDIAIQIVGVGFVIgviqDSCETALNSSTDVLFTAVAEY 313
PRK13628 PRK13628
serine/threonine transporter SstT; Provisional
239-443 1.04e-15

serine/threonine transporter SstT; Provisional


Pssm-ID: 184190 [Multi-domain]  Cd Length: 402  Bit Score: 79.14  E-value: 1.04e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898 239 NGVNAL------GLVVFSMCFGFVignMKEQGQALREFFDSLNEAIMRLVAVIMWYAPVGILFLIAGKIVEMEDMGVIG- 311
Cdd:PRK13628 137 NPINALlnanyiGILAWAIGLGLA---LRHASDTTKNVVNDLSEAVSQIVKWVIRFAPIGIFGLVASTLAETGFSALAGy 213
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898 312 GQLAMytvtVIVG-LLIHAVIVLPLLYFLVTRKNPW--VFIgGLLQALITALGTSSSSATLPITFKcLEENNGVDKRVTR 388
Cdd:PRK13628 214 AQLLA----VLVGcMLFVALVVNPLIVFWKIRRNPYplVFT-CLRESGVTAFFTRSSAANIPVNMA-LCEKLGLDEDTYS 287
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530378898 389 FVLPVGATINMDGtalyealAAIFI-----AQVNNF--ELNFGQIITISITATAASIGAAGI 443
Cdd:PRK13628 288 VSIPLGATINMAG-------AAITItvltlAAVHTLgiPVDLPTALLLSVVAAISACGASGV 342
SstT COG3633
Na+/serine and Na+/threonine symporter SstT [Amino acid transport and metabolism];
233-444 1.25e-14

Na+/serine and Na+/threonine symporter SstT [Amino acid transport and metabolism];


Pssm-ID: 442850  Cd Length: 406  Bit Score: 75.98  E-value: 1.25e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898 233 PVPGSVNGvNALGLVVFSMCFGFVignMKEQGQALREFFDSLNEAIMRLVAVIMWYAPVGILFLIAGKIVEMedmGVigG 312
Cdd:COG3633  137 PVNALANA-NYIGILAWAIGLGLA---LRHASDTTKTVLSDLSDAVSKIVRWVIRFAPLGIFGLVASTVATT---GF--S 207
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378898 313 QLAMYT--VTVIVG-LLIHAVIVLPLLYFLVTRKNPW--VFIGgLLQALITALGTSSSSATLPITFKcLEENNGVDKRVT 387
Cdd:COG3633  208 ALLGYAhlLAVLVGcMLFVALVVNPLIVFLKIRRNPYplVFTC-LRESGITAFFTRSSAANIPVNMA-LCEKLGLDEDTY 285
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530378898 388 RFVLPVGATINMDGtalyealAAIFI-----AQVN--NFELNFGQIITISITATAASIGAAGIP 444
Cdd:COG3633  286 SVSIPLGATINMAG-------AAITItvltlAAVHtlGIEVDLPTALLLSVVAAVSACGASGVA 342
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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