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Conserved domains on  [gi|530391285|ref|XP_005252129|]
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methylglutaconyl-CoA hydratase, mitochondrial isoform X9 [Homo sapiens]

Protein Classification

Clp protease/crotonase-like domain-containing protein( domain architecture ID 581041)

Clp protease/crotonase-like domain-containing protein similar to Oryza sativa enoyl-CoA delta isomerase which plays a role in fatty acid metabolism, which involves stabilization of an enolate anion intermediate derived from an acyl-CoA substrate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
crotonase-like super family cl23717
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
 86-217 3.08e-34

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


The actual alignment was detected with superfamily member PLN02600:

Pssm-ID: 474030 [Multi-domain]  Cd Length: 251  Bit Score: 123.76  E-value: 3.08e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  86 NRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKERAKMSSSEVGPFVSKIRAVI 165
Cdd:PLN02600   2 DSGIVELRLDRPEAKNAIGKEMLRGLRSAFEKIQADASARVVMLRSSVPGVFCAGADLKERRKMSPSEVQKFVNSLRSTF 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 530391285 166 NDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPG 217
Cdd:PLN02600  82 SSLEALSIPTIAVVEGAALGGGLELALSCDLRICGEEAVFGLPETGLAIIPG 133
 
Name Accession Description Interval E-value
PLN02600 PLN02600
enoyl-CoA hydratase
 86-217 3.08e-34

enoyl-CoA hydratase


Pssm-ID: 178210 [Multi-domain]  Cd Length: 251  Bit Score: 123.76  E-value: 3.08e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  86 NRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKERAKMSSSEVGPFVSKIRAVI 165
Cdd:PLN02600   2 DSGIVELRLDRPEAKNAIGKEMLRGLRSAFEKIQADASARVVMLRSSVPGVFCAGADLKERRKMSPSEVQKFVNSLRSTF 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 530391285 166 NDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPG 217
Cdd:PLN02600  82 SSLEALSIPTIAVVEGAALGGGLELALSCDLRICGEEAVFGLPETGLAIIPG 133
crotonase-like cd06558
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
 84-223 9.31e-28

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


Pssm-ID: 119339 [Multi-domain]  Cd Length: 195  Bit Score: 104.95  E-value: 9.31e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  84 EENRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEvPGIFCAGADLKERAKMSSS--EVGPFVSKI 161
Cdd:cd06558    4 ERDGGVATITLNRPEKRNALSLEMLDELAAALDEAEADPDVRVVVLTGA-GKAFCAGADLKELAALSDAgeEARAFIREL 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530391285 162 RAVINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGVTSST 223
Cdd:cd06558   83 QELLRALLRLPKPVIAAVNGAALGGGLELALACDIRIAAEDAKFGLPEVKLGLVPGGGGTQR 144
CaiD COG1024
Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase ...
 84-218 1.55e-25

Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase/carnithine racemase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440647 [Multi-domain]  Cd Length: 249  Bit Score: 100.63  E-value: 1.55e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  84 EENRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEvPGIFCAGADLKE-RAKMSSSEVGPFVSKIR 162
Cdd:COG1024    4 EREGGVATITLNRPEKLNALSLEMLAELAAALDEAEADPDVRVVVLTGA-GKAFCAGADLKElAAAADPEEARAFARGLQ 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 530391285 163 AVINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGG 218
Cdd:COG1024   83 RLFRALRRLPKPVIAAVNGAALGGGLELALACDLRIAAEDARFGLPEVRLGLIPGG 138
ECH_1 pfam00378
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
 84-218 5.33e-18

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase.


Pssm-ID: 395302 [Multi-domain]  Cd Length: 251  Bit Score: 80.48  E-value: 5.33e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285   84 EENRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSeVPGIFCAGADLKERAKMSSSEVGPFVSKIRA 163
Cdd:pfam00378   1 EINAGVAVITLNRPEAVNALSAELITELIQALEKLRTDPSVRAVVLTG-GDKAFCAGADLKEMYGEGPAHQALYRENVLD 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 530391285  164 VINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGG 218
Cdd:pfam00378  80 LWTLLYTCPKPVIAAVNGYAIGGGCELALACDIIIAADNASFGLNETKLGIIPGA 134
fa_ox_alpha_mit TIGR02441
fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of ...
 81-218 2.86e-08

fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of mitochondrial multifunctional fatty acid degradation enzyme complex. Subunit activities include: enoyl-CoA hydratase (EC 4.2.1.17) _ 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35). Some characterization in human (SP:P40939), pig (SP:Q29554), and rat (SP:Q64428). The beta subunit has activity: acetyl-CoA C-acyltransferase (EC 2.3.1.16).


Pssm-ID: 131494 [Multi-domain]  Cd Length: 737  Bit Score: 54.07  E-value: 2.86e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285   81 HLEEENRG-IVVLGINRAYGK-NSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKE-RAKMSSSEVGPF 157
Cdd:TIGR02441  14 HRHYEVKGdVAVVKIDSPNSKvNTLSKELFAEFKEVMNELWTNEAIKSAVLISGKPGSFVAGADIQMiAACKTAQEVTQL 93

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530391285  158 VSKIRAVINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAK--MGLVETKLAIIPGG 218
Cdd:TIGR02441  94 SQEGQEMFERIEKSQKPIVAAISGSCLGGGLELALACHYRIATKDRKtlLGLPEVMLGLLPGA 156
 
Name Accession Description Interval E-value
PLN02600 PLN02600
enoyl-CoA hydratase
 86-217 3.08e-34

enoyl-CoA hydratase


Pssm-ID: 178210 [Multi-domain]  Cd Length: 251  Bit Score: 123.76  E-value: 3.08e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  86 NRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKERAKMSSSEVGPFVSKIRAVI 165
Cdd:PLN02600   2 DSGIVELRLDRPEAKNAIGKEMLRGLRSAFEKIQADASARVVMLRSSVPGVFCAGADLKERRKMSPSEVQKFVNSLRSTF 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 530391285 166 NDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPG 217
Cdd:PLN02600  82 SSLEALSIPTIAVVEGAALGGGLELALSCDLRICGEEAVFGLPETGLAIIPG 133
PRK07657 PRK07657
enoyl-CoA hydratase; Provisional
 86-217 4.00e-33

enoyl-CoA hydratase; Provisional


Pssm-ID: 181069 [Multi-domain]  Cd Length: 260  Bit Score: 120.99  E-value: 4.00e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  86 NRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKERAKMSSSEVGPFVSKIRAVI 165
Cdd:PRK07657  11 TPHVVKITLNRPRAANALSLALLEELQNILTQINEEANVRVVILTGAGEKAFCAGADLKERAGMNEEQVRHAVSLIRTTM 90

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 530391285 166 NDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPG 217
Cdd:PRK07657  91 EMVEQLPQPVIAAINGIALGGGLELALACDFRIAAESASLGLTETTLAIIPG 142
crotonase-like cd06558
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
 84-223 9.31e-28

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


Pssm-ID: 119339 [Multi-domain]  Cd Length: 195  Bit Score: 104.95  E-value: 9.31e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  84 EENRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEvPGIFCAGADLKERAKMSSS--EVGPFVSKI 161
Cdd:cd06558    4 ERDGGVATITLNRPEKRNALSLEMLDELAAALDEAEADPDVRVVVLTGA-GKAFCAGADLKELAALSDAgeEARAFIREL 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530391285 162 RAVINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGVTSST 223
Cdd:cd06558   83 QELLRALLRLPKPVIAAVNGAALGGGLELALACDIRIAAEDAKFGLPEVKLGLVPGGGGTQR 144
CaiD COG1024
Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase ...
 84-218 1.55e-25

Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase/carnithine racemase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440647 [Multi-domain]  Cd Length: 249  Bit Score: 100.63  E-value: 1.55e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  84 EENRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEvPGIFCAGADLKE-RAKMSSSEVGPFVSKIR 162
Cdd:COG1024    4 EREGGVATITLNRPEKLNALSLEMLAELAAALDEAEADPDVRVVVLTGA-GKAFCAGADLKElAAAADPEEARAFARGLQ 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 530391285 163 AVINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGG 218
Cdd:COG1024   83 RLFRALRRLPKPVIAAVNGAALGGGLELALACDLRIAAEDARFGLPEVRLGLIPGG 138
PRK06688 PRK06688
enoyl-CoA hydratase; Provisional
 71-218 2.55e-20

enoyl-CoA hydratase; Provisional


Pssm-ID: 235852 [Multi-domain]  Cd Length: 259  Bit Score: 86.85  E-value: 2.55e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  71 MKTEDELRVrHLEEenrGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSeVPGIFCAGADLKERAKmS 150
Cdd:PRK06688   1 MTMVTDLLV-ELED---GVLTITINRPDKKNALTAAMYQALADALEAAATDPAVRVVVLTG-AGRAFSAGGDIKDFPK-A 74

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530391285 151 SSEVGPFVSKIRAVINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGG 218
Cdd:PRK06688  75 PPKPPDELAPVNRFLRAIAALPKPVVAAVNGPAVGVGVSLALACDLVYASESAKFSLPFAKLGLCPDA 142
fadB PRK11730
fatty acid oxidation complex subunit alpha FadB;
77-217 4.42e-19

fatty acid oxidation complex subunit alpha FadB;


Pssm-ID: 183293 [Multi-domain]  Cd Length: 715  Bit Score: 86.07  E-value: 4.42e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  77 LRVRHLEEenrGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPgIFCAGADLKERA---KMSSSE 153
Cdd:PRK11730   8 LQVDWLED---GIAELVFDAPGSVNKLDRATLASLGEALDALEAQSDLKGLLLTSAKD-AFIVGADITEFLslfAAPEEE 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530391285 154 VGPFVSKIRAVINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPG 217
Cdd:PRK11730  84 LSQWLHFANSIFNRLEDLPVPTVAAINGYALGGGCECVLATDYRVASPDARIGLPETKLGIMPG 147
ECH_1 pfam00378
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
 84-218 5.33e-18

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase.


Pssm-ID: 395302 [Multi-domain]  Cd Length: 251  Bit Score: 80.48  E-value: 5.33e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285   84 EENRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSeVPGIFCAGADLKERAKMSSSEVGPFVSKIRA 163
Cdd:pfam00378   1 EINAGVAVITLNRPEAVNALSAELITELIQALEKLRTDPSVRAVVLTG-GDKAFCAGADLKEMYGEGPAHQALYRENVLD 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 530391285  164 VINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGG 218
Cdd:pfam00378  80 LWTLLYTCPKPVIAAVNGYAIGGGCELALACDIIIAADNASFGLNETKLGIIPGA 134
PRK07658 PRK07658
enoyl-CoA hydratase; Provisional
 88-217 9.54e-18

enoyl-CoA hydratase; Provisional


Pssm-ID: 181070 [Multi-domain]  Cd Length: 257  Bit Score: 80.06  E-value: 9.54e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  88 GIVVLGINRAYGkNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEvpG-IFCAGADLKE-RAKMSSSEVGPFVSKIRAVI 165
Cdd:PRK07658  11 HVAVITLNHPPA-NALSSQVLHELSELLDQVEKDDNVRVVVIHGE--GrFFSAGADIKEfTSVTEAEQATELAQLGQVTF 87

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 530391285 166 NDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPG 217
Cdd:PRK07658  88 ERVEKFSKPVIAAIHGAALGGGLELAMSCHIRFATESAKLGLPELNLGLIPG 139
PRK07468 PRK07468
crotonase/enoyl-CoA hydratase family protein;
81-216 8.25e-16

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 180987 [Multi-domain]  Cd Length: 262  Bit Score: 74.71  E-value: 8.25e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  81 HLEEENRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGiFCAGADLK-ERAKMSSSEVGPFVS 159
Cdd:PRK07468   7 RIAVDARGVATLTLNRPEKHNALSARMIAELTTAARRLAADAAVRVVVLTGAGKS-FCAGGDLGwMRAQMTADRATRIEE 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 530391285 160 --KIRAVINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIP 216
Cdd:PRK07468  86 arRLAMMLKALNDLPKPLIGRIQGQAFGGGVGLISVCDVAIAVSGARFGLTETRLGLIP 144
PRK06143 PRK06143
enoyl-CoA hydratase; Provisional
 87-214 1.58e-15

enoyl-CoA hydratase; Provisional


Pssm-ID: 180423  Cd Length: 256  Bit Score: 73.92  E-value: 1.58e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  87 RGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKERAKMSSSEVGPFVSKIRAVIN 166
Cdd:PRK06143  15 RGVATLTIRNAGSLNILGTPVILALTQALRWLAADPDVRVLVLRGAGEKAFIGGADIKEMATLDQASAEAFISRLRDLCD 94

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 530391285 167 DIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAI 214
Cdd:PRK06143  95 AVRHFPVPVIARIPGWCLGGGLELAAACDLRIAAHDAQFGMPEVRVGI 142
PRK05809 PRK05809
short-chain-enoyl-CoA hydratase;
84-217 1.14e-14

short-chain-enoyl-CoA hydratase;


Pssm-ID: 180270 [Multi-domain]  Cd Length: 260  Bit Score: 71.32  E-value: 1.14e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  84 EENRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKERAKMSSSEVGPFVSKIRA 163
Cdd:PRK05809   9 EKEGHIAVVTINRPKALNALNSETLKELDTVLDDIENDDNVYAVILTGAGEKAFVAGADISEMKDLNEEEGRKFGLLGNK 88

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 530391285 164 VINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPG 217
Cdd:PRK05809  89 VFRKLENLDKPVIAAINGFALGGGCELSMACDIRIASEKAKFGQPEVGLGITPG 142
PRK08138 PRK08138
enoyl-CoA hydratase; Provisional
 74-217 1.69e-13

enoyl-CoA hydratase; Provisional


Pssm-ID: 236162 [Multi-domain]  Cd Length: 261  Bit Score: 68.15  E-value: 1.69e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  74 EDELRVRHLEEenrGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIII--RSEVpgiFCAGADLKERAKMSS 151
Cdd:PRK08138   6 TDVVLLERPAD---GVALLRLNRPEARNALNMEVRQQLAEHFTELSEDPDIRAIVLtgGEKV---FAAGADIKEFATAGA 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530391285 152 SEVgpFVSKIRAVINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPG 217
Cdd:PRK08138  80 IEM--YLRHTERYWEAIAQCPKPVIAAVNGYALGGGCELAMHADIIVAGESASFGQPEIKVGLMPG 143
PRK05995 PRK05995
enoyl-CoA hydratase; Provisional
 81-221 2.63e-13

enoyl-CoA hydratase; Provisional


Pssm-ID: 235664 [Multi-domain]  Cd Length: 262  Bit Score: 67.64  E-value: 2.63e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  81 HLEEENRGIV-VLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGiFCAGADL---KERAKMSSSEVGP 156
Cdd:PRK05995   5 TLEIEQRGQVaTVTLNRPDVRNAFNETVIAELTAAFRALDADDSVRAVVLAGAGKA-FCAGADLnwmKKMAGYSDDENRA 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530391285 157 FVSKIRAVINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGVTS 221
Cdd:PRK05995  84 DARRLADMLRAIYRCPKPVIARVHGDAYAGGMGLVAACDIAVAADHAVFCLSEVRLGLIPATISP 148
PRK08139 PRK08139
enoyl-CoA hydratase; Validated
 82-204 3.33e-13

enoyl-CoA hydratase; Validated


Pssm-ID: 181249  Cd Length: 266  Bit Score: 67.27  E-value: 3.33e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  82 LEEENRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPgIFCAGADLKE-RAKMSSSEVGPFVSK 160
Cdd:PRK08139  14 LREDRDGVATLTLNRPQAFNALSEAMLAALQAALDAIAADPSVRVVVLAAAGK-AFCAGHDLKEmRAARGLAYFRALFAR 92

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 530391285 161 IRAVINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAK 204
Cdd:PRK08139  93 CSRVMQAIVALPQPVIARVHGIATAAGCQLVASCDLAVAADTAR 136
PRK07799 PRK07799
crotonase/enoyl-CoA hydratase family protein;
81-218 5.10e-13

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181122 [Multi-domain]  Cd Length: 263  Bit Score: 67.05  E-value: 5.10e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  81 HLEEENRG-IVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIrSEVPGIFCAGADLKERAKMSSSEV---GP 156
Cdd:PRK07799   6 HALVEQRGhTLIVTMNRPEARNALSTEMLRIMVDAWDRVDNDPDIRSCIL-TGAGGAFCAGMDLKAATKKPPGDSfkdGS 84

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530391285 157 F-VSKIRAVINDiANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGG 218
Cdd:PRK07799  85 YdPSRIDALLKG-RRLTKPLIAAVEGPAIAGGTEILQGTDIRVAGESAKFGISEAKWSLFPMG 146
PRK07827 PRK07827
enoyl-CoA hydratase family protein;
84-216 1.23e-12

enoyl-CoA hydratase family protein;


Pssm-ID: 236109 [Multi-domain]  Cd Length: 260  Bit Score: 65.86  E-value: 1.23e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  84 EENRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIrSEVPGIFCAGADLKERAKMSSSEVGPFVSKIRA 163
Cdd:PRK07827  11 AVDGGVATLTLDSPHNRNALSARLVAQLHDGLRAAAADPAVRAVVL-THTGGTFCAGADLSEAGGGGGDPYDAAVARARE 89

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 530391285 164 VIN---DIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIP 216
Cdd:PRK07827  90 MTAllrAIVELPKPVIAAIDGHVRAGGFGLVGACDIVVAGPESTFALTEARIGVAP 145
PRK09245 PRK09245
crotonase/enoyl-CoA hydratase family protein;
82-217 3.24e-12

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181723  Cd Length: 266  Bit Score: 64.61  E-value: 3.24e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  82 LEEENRGIVVLGINRAYGKNSLSKN-LIKMLSKAVDALKSDKKVRTIIIRSEVPgIFCAGADLKE-RAKMSSSEVGPFVS 159
Cdd:PRK09245   6 LVERDGHIVTLTMNRPETRNALSDNdAVDALVAACAAINADRSVRAVILTGAGT-AFSSGGNVKDmRARVGAFGGSPADI 84

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530391285 160 K------IRAVINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPG 217
Cdd:PRK09245  85 RqgyrhgIQRIPLALYNLEVPVIAAVNGPAIGAGCDLACMCDIRIASETARFAESFVKLGLIPG 148
PRK05870 PRK05870
enoyl-CoA hydratase; Provisional
 88-218 5.61e-12

enoyl-CoA hydratase; Provisional


Pssm-ID: 180298  Cd Length: 249  Bit Score: 63.59  E-value: 5.61e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  88 GIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGiFCAGADLKERAKMSSSEVGPFVSKIRAVIND 167
Cdd:PRK05870  12 GVALITVNDPDRRNAVTAEMSAQLRAAVAAAEADPDVHALVVTGAGKA-FCAGADLTALGAAPGRPAEDGLRRIYDGFLA 90

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 530391285 168 IANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGG 218
Cdd:PRK05870  91 VASCPLPTIAAVNGAAVGAGLNLALAADVRIAGPKALFDARFQKLGLHPGG 141
PRK05862 PRK05862
enoyl-CoA hydratase; Provisional
 85-217 1.83e-11

enoyl-CoA hydratase; Provisional


Pssm-ID: 180295 [Multi-domain]  Cd Length: 257  Bit Score: 62.37  E-value: 1.83e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  85 ENRGIV-VLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIR-SEvpGIFCAGADLKERAKMSSSEVgpFVSKIR 162
Cdd:PRK05862   9 ETRGRVgLITLNRPKALNALNDALMDELGAALAAFDADEGIGAIVITgSE--KAFAAGADIKEMADLSFMDV--YKGDYI 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 530391285 163 AVINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPG 217
Cdd:PRK05862  85 TNWEKVARIRKPVIAAVAGYALGGGCELAMMCDIIIAADTAKFGQPEIKLGVLPG 139
PRK07509 PRK07509
crotonase/enoyl-CoA hydratase family protein;
78-216 1.83e-11

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181008 [Multi-domain]  Cd Length: 262  Bit Score: 62.21  E-value: 1.83e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  78 RVRhLEEENrGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEvPGIFCAGADLKERAKMSSSEVGpf 157
Cdd:PRK07509   4 RVS-VTIED-GIADVRLNRPDKMNALDFAMFEELIATIKRLKKDRGIRAVILSGE-GGAFCAGLDVKSVASSPGNAVK-- 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285 158 vsKIRAVINDIAN-----------LPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIP 216
Cdd:PRK07509  79 --LLFKRLPGNANlaqrvslgwrrLPVPVIAALEGVCFGGGLQIALGADIRIAAPDTKLSIMEAKWGLVP 146
PRK09674 PRK09674
enoyl-CoA hydratase-isomerase; Provisional
 88-217 4.33e-11

enoyl-CoA hydratase-isomerase; Provisional


Pssm-ID: 182026 [Multi-domain]  Cd Length: 255  Bit Score: 61.32  E-value: 4.33e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  88 GIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEvPGIFCAGADLKERAKMSssevgpfvskIRAVIND 167
Cdd:PRK09674  11 RVLLLTLNRPEARNALNNALLTQLVNELEAAATDTSIGVCVITGN-ARFFAAGADLNEMAEKD----------LAATLND 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 530391285 168 --------IANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPG 217
Cdd:PRK09674  80 prpqlwqrLQAFNKPLIAAVNGYALGAGCELALLCDIVIAGENARFGLPEITLGIMPG 137
PRK06144 PRK06144
enoyl-CoA hydratase; Provisional
 68-206 4.66e-10

enoyl-CoA hydratase; Provisional


Pssm-ID: 180424 [Multi-domain]  Cd Length: 262  Bit Score: 58.47  E-value: 4.66e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  68 SSEMKTEDELrvrhLEEENRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKERA 147
Cdd:PRK06144   1 MAMTTSTDEL----LLEVRGGIARITFNRPAARNAMTWAMYEGLAEICEAIAADPSIRAVVLRGAGDKAFVAGTDIAQFR 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285 148 KMSSSEVG-PFVSKIRAVINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMG 206
Cdd:PRK06144  77 AFSTAEDAvAYERRIDRVLGALEQLRVPTIAAIAGACVGGGAAIAAACDLRIATPSARFG 136
PRK08150 PRK08150
crotonase/enoyl-CoA hydratase family protein;
84-218 2.13e-09

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181254  Cd Length: 255  Bit Score: 56.57  E-value: 2.13e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  84 EENRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDkkVRTIIIRSEVPGiFCAGADLKERAKMSSSEVGPFVSKIRA 163
Cdd:PRK08150   7 ELDGGVATIGLNRPAKRNALNDGLIAALRAAFARLPEG--VRAVVLHGEGDH-FCAGLDLSELRERDAGEGMHHSRRWHR 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 530391285 164 VINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGG 218
Cdd:PRK08150  84 VFDKIQYGRVPVIAALHGAVVGGGLELASAAHIRVADESTYFALPEGQRGIFVGG 138
PRK06190 PRK06190
enoyl-CoA hydratase; Provisional
 82-218 7.32e-09

enoyl-CoA hydratase; Provisional


Pssm-ID: 235733  Cd Length: 258  Bit Score: 54.98  E-value: 7.32e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  82 LEEENRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPgIFCAGADLKERAKMSSSEVGPFVSK- 160
Cdd:PRK06190   7 LVETHDRVRTLTLNRPEARNALSAALRRALFAALAEADADDDVDVVVLTGADP-AFCAGLDLKELGGDGSAYGAQDALPn 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 530391285 161 -IRAVindiANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGG 218
Cdd:PRK06190  86 pSPAW----PAMRKPVIGAINGAAVTGGLELALACDILIASERARFADTHARVGILPGW 140
PLN02888 PLN02888
enoyl-CoA hydratase
 82-216 1.14e-08

enoyl-CoA hydratase


Pssm-ID: 215480  Cd Length: 265  Bit Score: 54.37  E-value: 1.14e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  82 LEEENRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGiFCAGADLKerakmSSSEVGPFVSKI 161
Cdd:PLN02888  13 VPKSRNGIATITINRPKALNALTRPMMVELAAAFKRLDEDDSVKVIILTGSGRA-FCSGVDLT-----AAEEVFKGDVKD 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 530391285 162 RAvINDIANLP---VPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIP 216
Cdd:PLN02888  87 VE-TDPVAQMErcrKPIIGAINGFAITAGFEIALACDILVASRGAKFIDTHAKFGIFP 143
PRK05674 PRK05674
gamma-carboxygeranoyl-CoA hydratase; Validated
 82-216 1.59e-08

gamma-carboxygeranoyl-CoA hydratase; Validated


Pssm-ID: 168168  Cd Length: 265  Bit Score: 54.04  E-value: 1.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  82 LEEENRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGiFCAGADL---KERAKMSSSEVGPFV 158
Cdd:PRK05674   9 LIRDPRGFATLWLSRADKNNAFNAQMIRELILALDQVQSDASLRFLLLRGRGRH-FSAGADLawmQQSADLDYNTNLDDA 87

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 530391285 159 SKIRAVINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIP 216
Cdd:PRK05674  88 RELAELMYNLYRLKIPTLAVVQGAAFGGALGLISCCDMAIGADDAQFCLSEVRIGLAP 145
PRK07854 PRK07854
enoyl-CoA hydratase; Provisional
 85-203 1.83e-08

enoyl-CoA hydratase; Provisional


Pssm-ID: 236115 [Multi-domain]  Cd Length: 243  Bit Score: 53.49  E-value: 1.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  85 ENRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALkSDKKVRTIIIRSEVPgIFCAGADLKERAKMSSsevgpFVSKIRAV 164
Cdd:PRK07854   6 RDGQVLTIELQRPERRNALNAELCEELREAVRKA-VDESARAIVLTGQGT-VFCAGADLSGDVYADD-----FPDALIEM 78

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 530391285 165 INDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSA 203
Cdd:PRK07854  79 LHAIDAAPVPVIAAINGPAIGAGLQLAMACDLRVVAPEA 117
fa_ox_alpha_mit TIGR02441
fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of ...
 81-218 2.86e-08

fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of mitochondrial multifunctional fatty acid degradation enzyme complex. Subunit activities include: enoyl-CoA hydratase (EC 4.2.1.17) _ 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35). Some characterization in human (SP:P40939), pig (SP:Q29554), and rat (SP:Q64428). The beta subunit has activity: acetyl-CoA C-acyltransferase (EC 2.3.1.16).


Pssm-ID: 131494 [Multi-domain]  Cd Length: 737  Bit Score: 54.07  E-value: 2.86e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285   81 HLEEENRG-IVVLGINRAYGK-NSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKE-RAKMSSSEVGPF 157
Cdd:TIGR02441  14 HRHYEVKGdVAVVKIDSPNSKvNTLSKELFAEFKEVMNELWTNEAIKSAVLISGKPGSFVAGADIQMiAACKTAQEVTQL 93

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530391285  158 VSKIRAVINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAK--MGLVETKLAIIPGG 218
Cdd:TIGR02441  94 SQEGQEMFERIEKSQKPIVAAISGSCLGGGLELALACHYRIATKDRKtlLGLPEVMLGLLPGA 156
PRK08252 PRK08252
crotonase/enoyl-CoA hydratase family protein;
73-218 3.87e-08

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181325 [Multi-domain]  Cd Length: 254  Bit Score: 52.68  E-value: 3.87e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  73 TEDELRVrhleEENRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIrSEVPGIFCAGADLKERAKmsss 152
Cdd:PRK08252   1 MSDEVLV----ERRGRVLIITINRPEARNAVNAAVAQGLAAALDELDADPDLSVGIL-TGAGGTFCAGMDLKAFAR---- 71

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530391285 153 evGPFVSKIRAVINDIANLPV--PTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGG 218
Cdd:PRK08252  72 --GERPSIPGRGFGGLTERPPrkPLIAAVEGYALAGGFELALACDLIVAARDAKFGLPEVKRGLVAAG 137
PRK06495 PRK06495
enoyl-CoA hydratase/isomerase family protein;
101-218 4.31e-08

enoyl-CoA hydratase/isomerase family protein;


Pssm-ID: 168580 [Multi-domain]  Cd Length: 257  Bit Score: 52.77  E-value: 4.31e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285 101 NSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEvPGIFCAGADLKERAKMSSSEvGPFVS---KIRAVINDIANLPVPTIA 177
Cdd:PRK06495  25 NALSRELRDELIAVFDEISERPDVRVVVLTGA-GKVFCAGADLKGRPDVIKGP-GDLRAhnrRTRECFHAIRECAKPVIA 102

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 530391285 178 AIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGG 218
Cdd:PRK06495 103 AVNGPALGAGLGLVASCDIIVASENAVFGLPEIDVGLAGGG 143
fadJ PRK11154
fatty acid oxidation complex subunit alpha FadJ;
118-218 4.42e-08

fatty acid oxidation complex subunit alpha FadJ;


Pssm-ID: 236864 [Multi-domain]  Cd Length: 708  Bit Score: 53.36  E-value: 4.42e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285 118 LKSDKKVRTIIIRSEVPGIFCAGADLKERAKMSSSEVGPFVSKI-RAVINDIANLPVPTIAAIDGLALGGGLELALACDI 196
Cdd:PRK11154  46 LREDKELKGVVFISGKPDNFIAGADINMLAACKTAQEAEALARQgQQLFAEIEALPIPVVAAIHGACLGGGLELALACHY 125

                         90       100
                 ....*....|....*....|....
gi 530391285 197 RVAASSAK--MGLVETKLAIIPGG 218
Cdd:PRK11154 126 RVCTDDPKtvLGLPEVQLGLLPGS 149
PRK06127 PRK06127
enoyl-CoA hydratase; Provisional
 88-214 6.69e-08

enoyl-CoA hydratase; Provisional


Pssm-ID: 235705  Cd Length: 269  Bit Score: 52.02  E-value: 6.69e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  88 GIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKERAKMSSSE--VGPFVSKIRAVI 165
Cdd:PRK06127  20 GLGRITFNNPARHNAMSLDMWEALPQALAAAEDDDAIRVVVLTGAGEKAFVSGADISQFEESRSDAeaVAAYEQAVEAAQ 99

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 530391285 166 NDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAI 214
Cdd:PRK06127 100 AALADYAKPTIACIRGYCIGGGMGIALACDIRIAAEDSRFGIPAARLGL 148
PRK07511 PRK07511
enoyl-CoA hydratase; Provisional
 91-222 6.97e-08

enoyl-CoA hydratase; Provisional


Pssm-ID: 181009 [Multi-domain]  Cd Length: 260  Bit Score: 51.92  E-value: 6.97e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  91 VLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEvPGIFCAGADLK---ERAKMSSSEVGPFVSKIRAVIND 167
Cdd:PRK07511  15 VLTLSNPGARNALHPDMYAAGIEALNTAERDPSIRAVVLTGA-GGFFCAGGNLNrllENRAKPPSVQAASIDGLHDWIRA 93

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 530391285 168 IANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIP-GGVTSS 222
Cdd:PRK07511  94 IRAFPKPVIAAVEGAAAGAGFSLALACDLLVAARDAKFVMAYVKVGLTPdGGGSWF 149
PRK05980 PRK05980
crotonase/enoyl-CoA hydratase family protein;
82-216 2.00e-07

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 180335 [Multi-domain]  Cd Length: 260  Bit Score: 50.53  E-value: 2.00e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  82 LEEENRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKE----RAKMSSSEVGPF 157
Cdd:PRK05980   6 LIEIRDGIALLTLNRPEKLNALNYALIDRLLARLDAIEVDESVRAVILTGAGDRAFSAGADIHEfsasVAAGADVALRDF 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 530391285 158 VSKIRAVINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIP 216
Cdd:PRK05980  86 VRRGQAMTARLEAFPKPVIAAVNGLAFGGGCEITEAVHLAIASERALFAKPEIRLGMPP 144
PRK05869 PRK05869
enoyl-CoA hydratase; Validated
 84-231 3.96e-07

enoyl-CoA hydratase; Validated


Pssm-ID: 235632 [Multi-domain]  Cd Length: 222  Bit Score: 49.45  E-value: 3.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  84 EENRGIVVLGINRAyGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEvPGIFCAGADLKERAKMSSSEVGPFVSKIRA 163
Cdd:PRK05869  13 SQDAGLATLLLSRP-PTNALTRQVYREIVAAANELGRRDDVAAVILYGG-HEIFSAGDDMPELRTLSAQEADTAARVRQQ 90

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285 164 VINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIP--GGVTSSTEVLNPSKS 231
Cdd:PRK05869  91 AVDAVAAIPKPTVAAITGYALGAGLTLALAADWRVSGDNVKFGATEILAGLAPsgDGMARLTRAAGPSRA 160
PRK06210 PRK06210
enoyl-CoA hydratase; Provisional
 83-204 7.83e-07

enoyl-CoA hydratase; Provisional


Pssm-ID: 180472  Cd Length: 272  Bit Score: 48.93  E-value: 7.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  83 EEENRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGiFCAGADLKE------RAKMSSSEVGP 156
Cdd:PRK06210  10 EVADSGVAVITLNRPDRLNAWTPVMEAEVYAAMDRAEADPAVRVIVLTGAGRG-FCAGADMGElqtidpSDGRRDTDVRP 88

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 530391285 157 FVSKIRAVIND----IANLPVPTIAAIDGLALGGGLELALACDIRVAASSAK 204
Cdd:PRK06210  89 FVGNRRPDYQTryhfLTALRKPVIAAINGACAGIGLTHALMCDVRFAADGAK 140
PRK09076 PRK09076
enoyl-CoA hydratase; Provisional
 80-216 1.52e-06

enoyl-CoA hydratase; Provisional


Pssm-ID: 236373 [Multi-domain]  Cd Length: 258  Bit Score: 47.99  E-value: 1.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  80 RHLEEENRG-IVVLGINR--AygkNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKErakmsssevgp 156
Cdd:PRK09076   3 IELDLEIDGhVAILTLNNppA---NTWTADSLQALKQLVLELNADKDVYALVITGDGEKFFSAGADLNL----------- 68

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530391285 157 FVSKIRAVINDIA-----------NLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIP 216
Cdd:PRK09076  69 FADGDKAVAREMArrfgeafealsAFRGVSIAAINGYAMGGGLECALACDIRIAEEQAQMALPEASVGLLP 139
PLN02664 PLN02664
enoyl-CoA hydratase/delta3,5-delta2,4-dienoyl-CoA isomerase
 86-215 2.75e-06

enoyl-CoA hydratase/delta3,5-delta2,4-dienoyl-CoA isomerase


Pssm-ID: 178269 [Multi-domain]  Cd Length: 275  Bit Score: 47.20  E-value: 2.75e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  86 NRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVrTIIIRSEVPGIFCAGADLKERAKMS----SSEVGPFVSKI 161
Cdd:PLN02664  15 NSSVFHLNLNRPSQRNALSLDFFTEFPKALSSLDQNPNV-SVIILSGAGDHFCSGIDLKTLNSISeqssSGDRGRSGERL 93

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530391285 162 R-------AVINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAII 215
Cdd:PLN02664  94 RrkikflqDAITAIEQCRKPVIAAIHGACIGGGVDIVTACDIRYCSEDAFFSVKEVDLAIT 154
PRK05617 PRK05617
3-hydroxyisobutyryl-CoA hydrolase; Provisional
 73-144 5.01e-06

3-hydroxyisobutyryl-CoA hydrolase; Provisional


Pssm-ID: 235533 [Multi-domain]  Cd Length: 342  Bit Score: 46.74  E-value: 5.01e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530391285  73 TEDELRVrhlEEENR-GIVVLgiNRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLK 144
Cdd:PRK05617   1 TEDEVLA---EVEGGvGVITL--NRPKALNALSLEMIRAIDAALDAWEDDDAVAAVVIEGAGERGFCAGGDIR 68
PRK06072 PRK06072
enoyl-CoA hydratase; Provisional
 84-204 5.49e-06

enoyl-CoA hydratase; Provisional


Pssm-ID: 168377 [Multi-domain]  Cd Length: 248  Bit Score: 46.31  E-value: 5.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  84 EENRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGiFCAGADLkerakmsSSEVGPFVSKIRA 163
Cdd:PRK06072   5 ESREGYAIVTMSRPDKLNALNLEMRNEFISKLKQINADPKIRVVIVTGEGRA-FCVGADL-------SEFAPDFAIDLRE 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 530391285 164 ----VINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAK 204
Cdd:PRK06072  77 tfypIIREIRFSDKIYISAINGVTAGACIGIALSTDFKFASRDVK 121
PRK08260 PRK08260
enoyl-CoA hydratase; Provisional
 88-216 1.34e-05

enoyl-CoA hydratase; Provisional


Pssm-ID: 236206 [Multi-domain]  Cd Length: 296  Bit Score: 45.38  E-value: 1.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  88 GIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIirseVPG---IFCAGADL---------KERAKMSSS--- 152
Cdd:PRK08260  13 GIATITLNRPDKLNAFTVTMARELIEAFDAADADDAVRAVI----VTGagrAFCAGADLsaggntfdlDAPRTPVEAdee 88

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530391285 153 -EVGPFVSKIR----AVINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIP 216
Cdd:PRK08260  89 dRADPSDDGVRdgggRVTLRIFDSLKPVIAAVNGPAVGVGATMTLAMDIRLASTAARFGFVFGRRGIVP 157
PRK08258 PRK08258
enoyl-CoA hydratase family protein;
61-211 1.38e-05

enoyl-CoA hydratase family protein;


Pssm-ID: 181329  Cd Length: 277  Bit Score: 45.34  E-value: 1.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  61 PAPKRGYSSEMKtedELRVRHLE-EENRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGiFCA 139
Cdd:PRK08258   1 MSPFRGSKRPLA---GYEARHFLwEVDDGVATITLNRPERKNPLTFESYAELRDLFRELVYADDVKAVVLTGAGGN-FCS 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530391285 140 GADLKE----RAKMSSSEVGPFVSKIRAVINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETK 211
Cdd:PRK08258  77 GGDVHEiigpLTKMDMPELLAFTRMTGDLVKAMRACPQPIIAAVDGVCAGAGAILAMASDLRLGTPSAKTAFLFTR 152
PRK11423 PRK11423
methylmalonyl-CoA decarboxylase; Provisional
 89-214 1.55e-05

methylmalonyl-CoA decarboxylase; Provisional


Pssm-ID: 236908 [Multi-domain]  Cd Length: 261  Bit Score: 45.02  E-value: 1.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  89 IVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKkVRTIIIRSEVPG-IFCAGADLKE-----RAKMSSSEvgPFVSKIR 162
Cdd:PRK11423  14 IATITFNNPAKRNALSKVLIDDLMQALSDLNRPE-IRVVILRAPSGSkVWSAGHDIHElpsggRDPLSYDD--PLRQILR 90

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 530391285 163 AvindIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAI 214
Cdd:PRK11423  91 M----IQKFPKPVIAMVEGSVWGGAFELIMSCDLIIAASTSTFAMTPANLGV 138
PRK06494 PRK06494
enoyl-CoA hydratase; Provisional
 88-233 1.70e-05

enoyl-CoA hydratase; Provisional


Pssm-ID: 180591 [Multi-domain]  Cd Length: 259  Bit Score: 45.03  E-value: 1.70e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  88 GIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKERAKMSSSEVGP--FVSkiravI 165
Cdd:PRK06494  13 HVTIVTLNRPEVMNALHLDAHFELEEVFDDFAADPEQWVAIVTGAGDKAFSAGNDLKEQAAGGKRGWPEsgFGG-----L 87

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285 166 NDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIP--GGVTSSTEVLnPSKSSM 233
Cdd:PRK06494  88 TSRFDLDKPIIAAVNGVAMGGGFELALACDLIVAAENATFALPEPRVGLAAlaGGLHRLPRQI-GLKRAM 156
PRK08140 PRK08140
enoyl-CoA hydratase; Provisional
 88-208 3.04e-05

enoyl-CoA hydratase; Provisional


Pssm-ID: 236163  Cd Length: 262  Bit Score: 44.13  E-value: 3.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  88 GIVVLGINRAYGKNSLSKNLIKMLSKAVDALKsDKKVRTIIIRSEVPGiFCAGADLKERAKMSSSEV-----------GP 156
Cdd:PRK08140  13 GVATLTLNRPDKLNSFTREMHRELREALDQVE-DDGARALLLTGAGRG-FCAGQDLADRDVTPGGAMpdlgesietfyNP 90

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 530391285 157 FVSKIRAvindianLPVPTIAAIDGLALGGGLELALACDIRVAASSA-------KMGLV 208
Cdd:PRK08140  91 LVRRLRA-------LPLPVIAAVNGVAAGAGANLALACDIVLAARSAsfiqafvKIGLV 142
ECH_2 pfam16113
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
 101-180 3.11e-05

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase. This family differs from pfam00378 in the structure of it's C-terminus.


Pssm-ID: 465024 [Multi-domain]  Cd Length: 331  Bit Score: 44.38  E-value: 3.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  101 NSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKERAKM----SSSEVGPFVSKIRAVINDIANLPVPTI 176
Cdd:pfam16113  13 NALNLEMVRALLAALKAWEDDPAVKLVVLKGAGERAFCAGGDVRALYEAakagGGEAGRDFFREEYRLNYLIATYPKPYV 92


                  ....
gi 530391285  177 AAID 180
Cdd:pfam16113  93 ALMD 96
PRK05864 PRK05864
enoyl-CoA hydratase; Provisional
 88-222 4.03e-05

enoyl-CoA hydratase; Provisional


Pssm-ID: 168278 [Multi-domain]  Cd Length: 276  Bit Score: 43.67  E-value: 4.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  88 GIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGiFCAGADLKERAKMSSSE-VGPFVSKIRA--- 163
Cdd:PRK05864  19 EIALITLNRPERMNSMAFDVMVPLKEALAEVSYDNSVRVVVLTGAGRG-FSSGADHKSAGVVPHVEgLTRPTYALRSmel 97

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530391285 164 ---VINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMglvetKLAIIPGGVTSS 222
Cdd:PRK05864  98 lddVILALRRLHQPVIAAVNGPAIGGGLCLALAADIRVASSSAYF-----RAAGINNGLTAS 154
PRK05981 PRK05981
enoyl-CoA hydratase/isomerase;
84-208 1.46e-04

enoyl-CoA hydratase/isomerase;


Pssm-ID: 235661  Cd Length: 266  Bit Score: 42.03  E-value: 1.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  84 EENRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDK-KVRTIIIRSEVPGiFCAGADLKER---AKMSSSEVG---- 155
Cdd:PRK05981   9 DFDGGVAILTLDHPEVMNAVSIDMLGGLAEALDAIEDGKaEVRCLVLTGAGRG-FCTGANLQGRgsgGRESDSGGDagaa 87

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530391285 156 ------PFVSKIRavindiaNLPVPTIAAIDGLALGGGLELALACDIRVAASSA-------KMGLV 208
Cdd:PRK05981  88 letayhPFLRRLR-------NLPCPIVTAVNGPAAGVGMSFALMGDLILCARSAyflqafrRIGLV 146
PRK07938 PRK07938
enoyl-CoA hydratase family protein;
81-209 1.84e-04

enoyl-CoA hydratase family protein;


Pssm-ID: 181174  Cd Length: 249  Bit Score: 41.88  E-value: 1.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  81 HLEEENRGIVVLGINRAyGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGiFCAGADLKERAKMSSSEV------ 154
Cdd:PRK07938   4 TSTTPEPGIAEVTVDYP-PVNALPSAGWFALADAITAAGADPDTRVVVLRAEGRG-FNAGVDIKELQATPGFTAlidanr 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 530391285 155 GPFVSkIRAVINDianlPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVE 209
Cdd:PRK07938  82 GCFAA-FRAVYEC----AVPVIAAVHGFCLGGGIGLVGNADVIVASDDATFGLPE 131
PLN02921 PLN02921
naphthoate synthase
 88-223 2.76e-04

naphthoate synthase


Pssm-ID: 178509 [Multi-domain]  Cd Length: 327  Bit Score: 41.31  E-value: 2.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  88 GIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKERAKmsSSEVGPFVSKIRAVIN- 166
Cdd:PLN02921  76 GIAKITINRPERRNAFRPRTVKELQRAFNDARDDSSVGVIILTGKGTKAFCSGGDQAVRGK--DGYVGPDDAGRLNVLDl 153

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 530391285 167 --DIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGVTSST 223
Cdd:PLN02921 154 qiQIRRLPKPVIAMVAGYAVGGGHILHMVCDLTIAADNAVFGQTGPKVGSFDAGYGSSI 212
PRK09120 PRK09120
p-hydroxycinnamoyl CoA hydratase/lyase; Validated
 71-221 2.84e-04

p-hydroxycinnamoyl CoA hydratase/lyase; Validated


Pssm-ID: 236383  Cd Length: 275  Bit Score: 41.15  E-value: 2.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  71 MKTEDELRVRHLEEENrGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGiFCAGADLKE--RAK 148
Cdd:PRK09120   1 MSYENRWDTVKVEVED-GIAWVTLNRPEKRNAMSPTLNREMIDVLDALEFDDDAGVLVLTGAGDA-WSAGMDLKEyfRET 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 530391285 149 MSSSEVGpfVSKIRAVIND----IANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGVTS 221
Cdd:PRK09120  79 DAQPEIL--QERIRREAYGwwrrLRWYQKPTIAMVNGWCFGGGFSPLVACDLAIAADEAQFGLSEINWGIPPGGGVS 153
PLN03214 PLN03214
probable enoyl-CoA hydratase/isomerase; Provisional
 101-214 4.08e-04

probable enoyl-CoA hydratase/isomerase; Provisional


Pssm-ID: 215635  Cd Length: 278  Bit Score: 40.63  E-value: 4.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285 101 NSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEV-PGIFCAGADLKE--RAKMSSSEVGPFVSKIRAVINDIANLPVPTIA 177
Cdd:PLN03214  33 NSMTLAMWRSLDDALTALENDPTVRGVVFASGLrRDVFTAGNDIAElyAPKTSAARYAEFWLTQTTFLVRLLRSRLATVC 112

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 530391285 178 AIDGLALGGGLELALACDIRVAASSAKMGLVETKLAI 214
Cdd:PLN03214 113 AIRGACPAGGCAVSLCCDYRLQTTEGTMGLNEVALGI 149
PRK06563 PRK06563
crotonase/enoyl-CoA hydratase family protein;
85-220 4.89e-04

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 180625 [Multi-domain]  Cd Length: 255  Bit Score: 40.33  E-value: 4.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  85 ENRG-IVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGiFCAGADLKERA--------KMSSSEVG 155
Cdd:PRK06563   4 ERRGhVLLIGLDRPAKRNAFDSAMLDDLALALGEYEADDELRVAVLFAHGEH-FTAGLDLADVApklaaggfPFPEGGID 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530391285 156 PF------VSKiravindianlpvPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIP-GGVT 220
Cdd:PRK06563  83 PWgtvgrrLSK-------------PLVVAVQGYCLTLGIELMLAADIVVAADNTRFAQLEVQRGILPfGGAT 141
PRK06142 PRK06142
crotonase/enoyl-CoA hydratase family protein;
70-215 6.27e-04

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 235714  Cd Length: 272  Bit Score: 40.34  E-value: 6.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  70 EMKTEDELRVrhleEENRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEvpG-IFCAGADLKERA- 147
Cdd:PRK06142   1 MMTTYESFTV----ELADHVAQVTLNRPGKGNAMNPAFWSELPEIFRWLDADPEVRAVVLSGS--GkHFSYGIDLPAMAg 74

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530391285 148 ----KMSSSEVGP---FVSKIR---AVINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAII 215
Cdd:PRK06142  75 vfgqLGKDGLARPrtdLRREILrlqAAINAVADCRKPVIAAVQGWCIGGGVDLISACDMRYASADAKFSVREVDLGMV 152
PLN02267 PLN02267
enoyl-CoA hydratase/isomerase family protein
 99-179 1.03e-03

enoyl-CoA hydratase/isomerase family protein


Pssm-ID: 215151  Cd Length: 239  Bit Score: 39.31  E-value: 1.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  99 GKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLK--ERAKMSSSEVGPFVSKIRAVINDIANLPVPTI 176
Cdd:PLN02267  19 GEHRLNPTLIDSIRSALRQVKSQATPGSVLITTAEGKFFSNGFDLAwaQAAGSAPSRLHLMVAKLRPLVADLISLPMPTI 98


                 ...
gi 530391285 177 AAI 179
Cdd:PLN02267  99 AAV 101
PRK07110 PRK07110
polyketide biosynthesis enoyl-CoA hydratase; Validated
 76-208 1.79e-03

polyketide biosynthesis enoyl-CoA hydratase; Validated


Pssm-ID: 235936  Cd Length: 249  Bit Score: 38.80  E-value: 1.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  76 ELRVRHLEEENRGIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSeVPGIFCAGADLK-----ERAKMS 150
Cdd:PRK07110   2 MMKVVELREVEEGIAQVTMQDRVNKNAFSDELCDQLHEAFDTIAQDPRYKVVILTG-YPNYFATGGTQEgllslQTGKGT 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530391285 151 SSEVgPFVSKIravindiANLPVPTIAAIDGLALGGGLELALACDIRVA-------ASSAKMGLV 208
Cdd:PRK07110  81 FTEA-NLYSLA-------LNCPIPVIAAMQGHAIGGGLVLGLYADIVVLsresvytANFMKYGFT 137
PRK07260 PRK07260
enoyl-CoA hydratase; Provisional
 88-219 3.00e-03

enoyl-CoA hydratase; Provisional


Pssm-ID: 180910 [Multi-domain]  Cd Length: 255  Bit Score: 38.18  E-value: 3.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  88 GIVVLGINRAYGKNSLSKNLIKMLSKAVDALKSDKKVRTIIIRSEVPgIFCAGADLKERAKMSSSEVGPFVSKIRAVIND 167
Cdd:PRK07260  11 DLATLTLNRPEVSNGFNIPMCQEILEALRLAEEDPSVRFLLINANGK-VFSVGGDLVEMKRAVDEDDVQSLVKIAELVNE 89

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 530391285 168 IA----NLPVPTIAAIDGLALGGGLELALACDIRVAASSAKM--GLVETKLAIIPGGV 219
Cdd:PRK07260  90 ISfaikQLPKPVIMCVDGAVAGAAANMAVAADFCIASTKTKFiqAFVGVGLAPDAGGL 147
PRK03580 PRK03580
crotonobetainyl-CoA hydratase;
117-216 4.67e-03

crotonobetainyl-CoA hydratase;


Pssm-ID: 179599 [Multi-domain]  Cd Length: 261  Bit Score: 37.37  E-value: 4.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285 117 ALKSDKKVRTIIIRSEVPGIFCAGADLKERAKMSSSE----VGPFvskirAVINDIANLPVPTIAAIDGLALGGGLELAL 192
Cdd:PRK03580  40 NFRDDPELRVAIITGAGEKFFSAGWDLKAAAEGEAPDadfgPGGF-----AGLTEIFDLDKPVIAAVNGYAFGGGFELAL 114

                         90       100
                 ....*....|....*....|....
gi 530391285 193 ACDIRVAASSAKMGLVETKLAIIP 216
Cdd:PRK03580 115 AADFIVCADNASFALPEAKLGIVP 138
PRK07659 PRK07659
enoyl-CoA hydratase; Provisional
 69-218 7.58e-03

enoyl-CoA hydratase; Provisional


Pssm-ID: 236073 [Multi-domain]  Cd Length: 260  Bit Score: 36.93  E-value: 7.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530391285  69 SEMKTedelrVRHLEEENRGIVVLgiNRAYGKNSLSKNLIKMLSKAVDALK-SDKKVrtIIIRSEVPGiFCAGADLKERA 147
Cdd:PRK07659   3 SKMES-----VVVKYEGRVATIML--NRPEALNALDEPMLKELLQALKEVAeSSAHI--VVLRGNGRG-FSAGGDIKMML 72

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530391285 148 KMSSSEVGPFVSK-IRAVINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGG 218
Cdd:PRK07659  73 SSNDESKFDGVMNtISEIVVTLYTMPKLTISAIHGPAAGLGLSIALTADYVIADISAKLAMNFIGIGLIPDG 144
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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