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Conserved domains on  [gi|530396000|ref|XP_005253286|]
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tumor protein p53-inducible protein 11 isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
p53-inducible11 super family cl20821
Tumour protein p53-inducible protein 11; TP53 is a tumour suppressor gene, when switched on it ...
 10-114 4.62e-64

Tumour protein p53-inducible protein 11; TP53 is a tumour suppressor gene, when switched on it suppresses tumour development by inducing stable growth arrest or cell apoptosis. The tumour protein TP53 inducible protein 11 encoded for by the gene TP53I11, has a protein sequence of 189 amino acids in length and 21 kDa in mass. The role of this protein is thought to negatively regulate cell proliferation in response to stress, and therefore suppress tumour formation.


The actual alignment was detected with superfamily member pfam14936:

Pssm-ID: 464386  Cd Length: 179  Bit Score: 193.90  E-value: 4.62e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396000   10 MKKHSQTDLVSRLKTRKILGVGGEDDDGEVHRSKISQVLGNEIKFTIREPLGLRVWQFVSAVLFSGIAIMALAFPDQLYD 89
Cdd:pfam14936   1 MKKHSQTDLVSRLKTRKILGVGGEDDDGEVHRSKISQVLGNEIKFAVREPLGLRLWQLLSAVTFTAMALMALVFPNQLYE 80

                          90       100
                  ....*....|....*....|....*
gi 530396000   90 AVFDGAQVTSKTPIRLYGGALLNAA 114
Cdd:pfam14936  81 AVFDEELSDTKTSIRLYGGALLSIS 105
 
Name Accession Description Interval E-value
p53-inducible11 pfam14936
Tumour protein p53-inducible protein 11; TP53 is a tumour suppressor gene, when switched on it ...
 10-114 4.62e-64

Tumour protein p53-inducible protein 11; TP53 is a tumour suppressor gene, when switched on it suppresses tumour development by inducing stable growth arrest or cell apoptosis. The tumour protein TP53 inducible protein 11 encoded for by the gene TP53I11, has a protein sequence of 189 amino acids in length and 21 kDa in mass. The role of this protein is thought to negatively regulate cell proliferation in response to stress, and therefore suppress tumour formation.


Pssm-ID: 464386  Cd Length: 179  Bit Score: 193.90  E-value: 4.62e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396000   10 MKKHSQTDLVSRLKTRKILGVGGEDDDGEVHRSKISQVLGNEIKFTIREPLGLRVWQFVSAVLFSGIAIMALAFPDQLYD 89
Cdd:pfam14936   1 MKKHSQTDLVSRLKTRKILGVGGEDDDGEVHRSKISQVLGNEIKFAVREPLGLRLWQLLSAVTFTAMALMALVFPNQLYE 80

                          90       100
                  ....*....|....*....|....*
gi 530396000   90 AVFDGAQVTSKTPIRLYGGALLNAA 114
Cdd:pfam14936  81 AVFDEELSDTKTSIRLYGGALLSIS 105
 
Name Accession Description Interval E-value
p53-inducible11 pfam14936
Tumour protein p53-inducible protein 11; TP53 is a tumour suppressor gene, when switched on it ...
 10-114 4.62e-64

Tumour protein p53-inducible protein 11; TP53 is a tumour suppressor gene, when switched on it suppresses tumour development by inducing stable growth arrest or cell apoptosis. The tumour protein TP53 inducible protein 11 encoded for by the gene TP53I11, has a protein sequence of 189 amino acids in length and 21 kDa in mass. The role of this protein is thought to negatively regulate cell proliferation in response to stress, and therefore suppress tumour formation.


Pssm-ID: 464386  Cd Length: 179  Bit Score: 193.90  E-value: 4.62e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530396000   10 MKKHSQTDLVSRLKTRKILGVGGEDDDGEVHRSKISQVLGNEIKFTIREPLGLRVWQFVSAVLFSGIAIMALAFPDQLYD 89
Cdd:pfam14936   1 MKKHSQTDLVSRLKTRKILGVGGEDDDGEVHRSKISQVLGNEIKFAVREPLGLRLWQLLSAVTFTAMALMALVFPNQLYE 80

                          90       100
                  ....*....|....*....|....*
gi 530396000   90 AVFDGAQVTSKTPIRLYGGALLNAA 114
Cdd:pfam14936  81 AVFDEELSDTKTSIRLYGGALLSIS 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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