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Conserved domains on  [gi|530424023|ref|XP_005256063|]
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lysophosphatidylcholine acyltransferase 2 isoform X2 [Homo sapiens]

Protein Classification

glycerol-3-phosphate acyltransferase( domain architecture ID 10168560)

glycerol-3-phosphate acyltransferase (GPAT) catalyzes the incorporation of an acyl group from acylCoA into the acceptor glycerol 3-phosphate

CATH:  1.10.1200.50
EC:  2.3.1.-
Gene Ontology:  GO:0008374
SCOP:  4003349

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LPLAT_LPCAT1-like cd07991
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; ...
 116-287 2.95e-67

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lysophosphatidylcholine acyltransferase 1 (LPCAT-1), glycerol-3-phosphate acyltransferase 3 (GPAT3), and similar sequences.


:

Pssm-ID: 153253 [Multi-domain]  Cd Length: 211  Bit Score: 209.77  E-value: 2.95e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530424023 116 RAMFFSMGF-IVAVKGKIASPLEAPVFVAaPHSTFFDGIACVVAGLPSMVSRNENAQVPLIGRLLRAVQPVLVSRVDPDS 194
Cdd:cd07991    2 RVLLFAFGFyVIKVHGKPDPPEAPRIIVA-NHTSFIDPLILFSDLFPSIVAKKELGKLPFIGTILRALGCIFVDRSEPKD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530424023 195 RKNTINEIIKRTTSGgEWPQILVFPEGTCTNRSCLITFKPGAFIPGVPVQPVLLRYPNKLDTVTWTWQGYTFIQLCMLTF 274
Cdd:cd07991   81 RKKVVEEIKERATDP-NWPPILIFPEGTTTNGKALIMFKKGAFEPGVPVQPVAIRYPNKFVDAFWNSSGYSSLMYLFRLL 159

                        170
                 ....*....|...
gi 530424023 275 CQLFTKVEVEmFL 287
Cdd:cd07991  160 TQPANVLEVE-FL 171
 
Name Accession Description Interval E-value
LPLAT_LPCAT1-like cd07991
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; ...
 116-287 2.95e-67

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lysophosphatidylcholine acyltransferase 1 (LPCAT-1), glycerol-3-phosphate acyltransferase 3 (GPAT3), and similar sequences.


Pssm-ID: 153253 [Multi-domain]  Cd Length: 211  Bit Score: 209.77  E-value: 2.95e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530424023 116 RAMFFSMGF-IVAVKGKIASPLEAPVFVAaPHSTFFDGIACVVAGLPSMVSRNENAQVPLIGRLLRAVQPVLVSRVDPDS 194
Cdd:cd07991    2 RVLLFAFGFyVIKVHGKPDPPEAPRIIVA-NHTSFIDPLILFSDLFPSIVAKKELGKLPFIGTILRALGCIFVDRSEPKD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530424023 195 RKNTINEIIKRTTSGgEWPQILVFPEGTCTNRSCLITFKPGAFIPGVPVQPVLLRYPNKLDTVTWTWQGYTFIQLCMLTF 274
Cdd:cd07991   81 RKKVVEEIKERATDP-NWPPILIFPEGTTTNGKALIMFKKGAFEPGVPVQPVAIRYPNKFVDAFWNSSGYSSLMYLFRLL 159

                        170
                 ....*....|...
gi 530424023 275 CQLFTKVEVEmFL 287
Cdd:cd07991  160 TQPANVLEVE-FL 171
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 102-254 8.16e-20

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 86.22  E-value: 8.16e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530424023 102 WRRKITQTALKFLGRAMFFSMGFIVAVKGKIASPLEAPVFVAAPHSTFFDG--IACVVAGLPSMVSRNENAQVPLIGRLL 179
Cdd:COG0204    7 LLRRFRYRLVRLWARLLLRLLGVRVRVEGLENLPADGPVLIVANHQSWLDIllLLAALPRPVRFVAKKELFKIPLLGWLL 86

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530424023 180 RAVQPVLVSRVDPDSRKNTINEIIKRTTSGGewpQILVFPEGTCTNRSCLITFKPGAFI----PGVPVQPVLLRYPNKL 254
Cdd:COG0204   87 RALGAIPVDRSKRRAALRALRQAVEALKAGE---SLVIFPEGTRSPDGRLLPFKTGAARlaleAGVPIVPVAIDGTERA 162
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 142-250 3.26e-19

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 81.63  E-value: 3.26e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530424023   142 VAAPHSTFFDGIACVVA-----GLPSMVSRNENAQVPLIGRLLRAVQPVLVSRVDPDSRKNTINEIIKRTTSGGewpQIL 216
Cdd:smart00563   3 VVANHQSFLDPLVLSALlprklGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKARAALREAVELLKEGE---WLL 79

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 530424023   217 VFPEGTCTNRSCLITFKPGAFI----PGVPVQPVLLRY 250
Cdd:smart00563  80 IFPEGTRSRPGKLLPFKKGAARlaleAGVPIVPVAIRG 117
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 126-246 3.31e-13

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 65.76  E-value: 3.31e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530424023  126 VAVKGKIASPLEAPVFVAAPHSTFFDGI--ACVVA---GLPSMVSRNENAQVPLIGRLLRAVQPVLVSRVDPDSRKNTIN 200
Cdd:pfam01553   2 IEVHGLENLPRGGPAIVVANHQSYLDVLllSLALYkrgRPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAGTLE 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 530424023  201 EIIKRTTSGGewpQILVFPEGTCTNRSCLITFKPGAFI----PGVPVQPV 246
Cdd:pfam01553  82 YLVELLREGK---LVVIFPEGTRSREGELLPFKKGAFRlaieAGVPIVPV 128
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 123-249 4.49e-08

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 51.19  E-value: 4.49e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530424023  123 GFIVAVKGKIASPLEAPVFVAAPHSTFFDGIA--CVVAGLPSMVSRNENAQVPLIGRLLRAVQPVLVSRvdpDSRK--NT 198
Cdd:TIGR00530   1 GLKVEVVGPENLPAKSPVLVVANHQSNLDPLTlsAAFPPPIVFIAKKELKWIPFFGIMLWLTGAIFIDR---ENIRaiAT 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 530424023  199 INEIIKRTTSGGEwpQILVFPEGTCTNRSCLITFKPGAFI----PGVPVQPVLLR 249
Cdd:TIGR00530  78 ALKAAIEVLKQGR--SIGVFPEGTRSRGRDILPFKKGAFHiaikAGVPILPVVLS 130
PLN02833 PLN02833
glycerol acyltransferase family protein
 215-254 1.01e-04

glycerol acyltransferase family protein


Pssm-ID: 215447  Cd Length: 376  Bit Score: 43.61  E-value: 1.01e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 530424023 215 ILVFPEGTCTNRSCLITFKPGAFIPGVPVQPVLLRYpNKL 254
Cdd:PLN02833 240 LLIFPEGTCVNNEYTVMFKKGAFELGCTVCPIAIKY-NKI 278
 
Name Accession Description Interval E-value
LPLAT_LPCAT1-like cd07991
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; ...
 116-287 2.95e-67

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lysophosphatidylcholine acyltransferase 1 (LPCAT-1), glycerol-3-phosphate acyltransferase 3 (GPAT3), and similar sequences.


Pssm-ID: 153253 [Multi-domain]  Cd Length: 211  Bit Score: 209.77  E-value: 2.95e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530424023 116 RAMFFSMGF-IVAVKGKIASPLEAPVFVAaPHSTFFDGIACVVAGLPSMVSRNENAQVPLIGRLLRAVQPVLVSRVDPDS 194
Cdd:cd07991    2 RVLLFAFGFyVIKVHGKPDPPEAPRIIVA-NHTSFIDPLILFSDLFPSIVAKKELGKLPFIGTILRALGCIFVDRSEPKD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530424023 195 RKNTINEIIKRTTSGgEWPQILVFPEGTCTNRSCLITFKPGAFIPGVPVQPVLLRYPNKLDTVTWTWQGYTFIQLCMLTF 274
Cdd:cd07991   81 RKKVVEEIKERATDP-NWPPILIFPEGTTTNGKALIMFKKGAFEPGVPVQPVAIRYPNKFVDAFWNSSGYSSLMYLFRLL 159

                        170
                 ....*....|...
gi 530424023 275 CQLFTKVEVEmFL 287
Cdd:cd07991  160 TQPANVLEVE-FL 171
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 102-254 8.16e-20

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 86.22  E-value: 8.16e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530424023 102 WRRKITQTALKFLGRAMFFSMGFIVAVKGKIASPLEAPVFVAAPHSTFFDG--IACVVAGLPSMVSRNENAQVPLIGRLL 179
Cdd:COG0204    7 LLRRFRYRLVRLWARLLLRLLGVRVRVEGLENLPADGPVLIVANHQSWLDIllLLAALPRPVRFVAKKELFKIPLLGWLL 86

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530424023 180 RAVQPVLVSRVDPDSRKNTINEIIKRTTSGGewpQILVFPEGTCTNRSCLITFKPGAFI----PGVPVQPVLLRYPNKL 254
Cdd:COG0204   87 RALGAIPVDRSKRRAALRALRQAVEALKAGE---SLVIFPEGTRSPDGRLLPFKTGAARlaleAGVPIVPVAIDGTERA 162
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 142-250 3.26e-19

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 81.63  E-value: 3.26e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530424023   142 VAAPHSTFFDGIACVVA-----GLPSMVSRNENAQVPLIGRLLRAVQPVLVSRVDPDSRKNTINEIIKRTTSGGewpQIL 216
Cdd:smart00563   3 VVANHQSFLDPLVLSALlprklGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKARAALREAVELLKEGE---WLL 79

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 530424023   217 VFPEGTCTNRSCLITFKPGAFI----PGVPVQPVLLRY 250
Cdd:smart00563  80 IFPEGTRSRPGKLLPFKKGAARlaleAGVPIVPVAIRG 117
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 116-254 2.38e-18

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 81.16  E-value: 2.38e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530424023 116 RAMFFSMGFIVAVKGKIASPLEAPVFVAAPHSTFFDG--IACVVAGLPSMVSRNENAQVPLIGRLLRAVQPVLVSRVDPD 193
Cdd:cd07989    2 RLLLRLLGVRVRVEGLENLPPKGPVIIVANHQSYLDPlvLGAALPRPIRFVAKKELFKIPFLGWLLRLLGAIPIDRGNGR 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530424023 194 SRKNTINEIIKRTTSGGewpQILVFPEGTCTNRSCLITFKPGAFI----PGVPVQPVLLRYPNKL 254
Cdd:cd07989   82 SAREALREAIEALKEGE---SVVIFPEGTRSRDGELLPFKSGAFRlakeAGVPIVPVAISGTWGS 143
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 126-246 3.31e-13

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 65.76  E-value: 3.31e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530424023  126 VAVKGKIASPLEAPVFVAAPHSTFFDGI--ACVVA---GLPSMVSRNENAQVPLIGRLLRAVQPVLVSRVDPDSRKNTIN 200
Cdd:pfam01553   2 IEVHGLENLPRGGPAIVVANHQSYLDVLllSLALYkrgRPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAGTLE 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 530424023  201 EIIKRTTSGGewpQILVFPEGTCTNRSCLITFKPGAFI----PGVPVQPV 246
Cdd:pfam01553  82 YLVELLREGK---LVVIFPEGTRSREGELLPFKKGAFRlaieAGVPIVPV 128
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 120-252 3.50e-12

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 64.36  E-value: 3.50e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530424023 120 FSMGFIVAVKGKIASPLEAPVFVAAPHSTFFDGIACVVAGLPS-------MVSRNENAQVPLIGRLlravQPVLVSRVDP 192
Cdd:cd06551    8 FFGFVRLEVKGPPPPPGGGPVLFVSNHSSWWDGLILFLLLERGlrrdvygLMDEELLERYPFFTRL----GAFSVDRDSP 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530424023 193 DSRKNTINEIIKRTTSGGEWpqILVFPEGTCTNRS-CLITFKPGAFIP----GVPVQPVLLRYPN 252
Cdd:cd06551   84 RSAAKSLKYVARLLSKPGSV--VWIFPEGTRTRRDkRPLQFKPGVAHLaekaGVPIVPVALRYTF 146
LPLAT_AAK14816-like cd07992
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 126-253 1.24e-08

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized glycerol-3-phosphate acyltransferases such as the Plasmodium falciparum locus AAK14816 putative acyltransferase, and similar proteins.


Pssm-ID: 153254 [Multi-domain]  Cd Length: 203  Bit Score: 54.19  E-value: 1.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530424023 126 VAVKGKIASPLEAPVFVAAPHS-TFFDG--IACVVAGLPSMVSRNENAQVPLIGRLLRAVQPVLVSRVdPDSRKNTINEI 202
Cdd:cd07992   16 ITVVGRENVPKDGPVIFLGNHPnALIDPllLAATLRRPVRFLAKADLFKNPLIGWLLESFGAIPVYRP-KDLARGGIGKI 94

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530424023 203 IKRTT--------SGGEWpqILVFPEGTCTNRSCLITFKPGAFI----------PGVPVQPVLLRYPNK 253
Cdd:cd07992   95 SNAAVfdavgealKAGGA--IGIFPEGGSHDRPRLLPLKAGAARmalealeagqKDVKIVPVGLNYEDK 161
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 123-249 4.49e-08

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 51.19  E-value: 4.49e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530424023  123 GFIVAVKGKIASPLEAPVFVAAPHSTFFDGIA--CVVAGLPSMVSRNENAQVPLIGRLLRAVQPVLVSRvdpDSRK--NT 198
Cdd:TIGR00530   1 GLKVEVVGPENLPAKSPVLVVANHQSNLDPLTlsAAFPPPIVFIAKKELKWIPFFGIMLWLTGAIFIDR---ENIRaiAT 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 530424023  199 INEIIKRTTSGGEwpQILVFPEGTCTNRSCLITFKPGAFI----PGVPVQPVLLR 249
Cdd:TIGR00530  78 ALKAAIEVLKQGR--SIGVFPEGTRSRGRDILPFKKGAFHiaikAGVPILPVVLS 130
PLN02833 PLN02833
glycerol acyltransferase family protein
 215-254 1.01e-04

glycerol acyltransferase family protein


Pssm-ID: 215447  Cd Length: 376  Bit Score: 43.61  E-value: 1.01e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 530424023 215 ILVFPEGTCTNRSCLITFKPGAFIPGVPVQPVLLRYpNKL 254
Cdd:PLN02833 240 LLIFPEGTCVNNEYTVMFKKGAFELGCTVCPIAIKY-NKI 278
PLN02901 PLN02901
1-acyl-sn-glycerol-3-phosphate acyltransferase
 121-248 1.08e-04

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 215488 [Multi-domain]  Cd Length: 214  Bit Score: 42.80  E-value: 1.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530424023 121 SMGFIVAVKGK--IASPLEAPVFVAApHSTFFDGIACVVAGLP-SMVSRNENAQVPLIGRLLRAVQPVLVSRVDPDSRKN 197
Cdd:PLN02901  32 SPFYKIEVEGLenLPSPDEPAVYVSN-HQSFLDIYTLFHLGRPfKFISKTSIFLIPIIGWAMYMTGHIPLKRMDRRSQLE 110

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 530424023 198 TIN---EIIKRTTSggewpqILVFPEGTCTNRSCLITFKPGAFI----PGVPVQPVLL 248
Cdd:PLN02901 111 CLKrcmELLKKGAS------VFFFPEGTRSKDGKLAAFKKGAFSvaakTGVPVVPITL 162
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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