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Conserved domains on  [gi|530416909|ref|XP_005259150|]
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prostacyclin receptor isoform X1 [Homo sapiens]

Protein Classification

G protein-coupled receptor family protein( domain architecture ID 705710)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tm_GPCRs super family cl28897
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
14-259 1.30e-140

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


The actual alignment was detected with superfamily member cd15141:

Pssm-ID: 475119 [Multi-domain]  Cd Length: 301  Bit Score: 400.35  E-value: 1.30e-140
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  14 SVGPATSTLMFVAGVVGNGLALGILSARRPAR---PSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLARGgPA 90
Cdd:cd15141    1 DGHPATSTLMFAAGVVGNLLALGILGVHRKERrtkSSAFCVLVTGLAATDLLGTCFLSPMVFVSYAQNSSLLGLAAG-QP 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  91 LCDAFAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWC 170
Cdd:cd15141   80 LCHLFAFAMTFFGLASMLILFAMAVERCLAISHPYFYAQHSGRRLAKLALPAIYAFGALFCALPLLGVGRHKQYCPGTWC 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909 171 FLRMRW---AQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSL------GPRPRTGEDEVDHLILL 241
Cdd:cd15141  160 FIRMTVpghREPGSLAFSLLYASLMALLIAAIFLCNGSVTVSLCRMYRGQKARRGSLrrcgrlGWWLGQGEEEVDHLILL 239
                        250
                 ....*....|....*...
gi 530416909 242 ALMTVVMAVCSLPLTMRG 259
Cdd:cd15141  240 ALMTVIFVVCSLPLTIRA 257
 
Name Accession Description Interval E-value
7tmA_PGI2 cd15141
prostaglandin I2 receptor, member of the class A family of seven-transmembrane G ...
14-259 1.30e-140

prostaglandin I2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin I2 receptor (also called prostacyclin receptor or prostanoid IP receptor) is a class A, G protein-coupled receptor whose endogenous ligand is prostacyclin, which is the major product of cyclooxygenase metabolite of arachidonic acid that found predominantly in platelets and vascular smooth muscle cells (VSMCs). The PGI2 receptor is coupled to both G(s) and G(q) protein subtypes, resulting in increased cAMP formation, phosphoinositide turnover, and Ca2+ signaling. PGI2 receptor activation by prostacyclin induces VSMC differentiation and produces a potent vasodilation and inhibition of platelet aggregation.


Pssm-ID: 320269 [Multi-domain]  Cd Length: 301  Bit Score: 400.35  E-value: 1.30e-140
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  14 SVGPATSTLMFVAGVVGNGLALGILSARRPAR---PSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLARGgPA 90
Cdd:cd15141    1 DGHPATSTLMFAAGVVGNLLALGILGVHRKERrtkSSAFCVLVTGLAATDLLGTCFLSPMVFVSYAQNSSLLGLAAG-QP 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  91 LCDAFAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWC 170
Cdd:cd15141   80 LCHLFAFAMTFFGLASMLILFAMAVERCLAISHPYFYAQHSGRRLAKLALPAIYAFGALFCALPLLGVGRHKQYCPGTWC 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909 171 FLRMRW---AQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSL------GPRPRTGEDEVDHLILL 241
Cdd:cd15141  160 FIRMTVpghREPGSLAFSLLYASLMALLIAAIFLCNGSVTVSLCRMYRGQKARRGSLrrcgrlGWWLGQGEEEVDHLILL 239
                        250
                 ....*....|....*...
gi 530416909 242 ALMTVVMAVCSLPLTMRG 259
Cdd:cd15141  240 ALMTVIFVVCSLPLTIRA 257
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
30-255 5.75e-18

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 81.96  E-value: 5.75e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909   30 GNGLALGILSARRPARpSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGlargGPALCDAFAFAMTFFGLASMLI 109
Cdd:pfam00001   1 GNLLVILVILRNKKLR-TPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGDWPF----GSALCKIVGALFVVNGYASILL 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  110 LFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLgLGQHQQYCPGSWCFLRMRWAQPGGAAFSLAYA 189
Cdd:pfam00001  76 LTAISIDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLL-FGWTLTVPEGNVTVCFIDFPEDLSKPVSYTLL 154
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530416909  190 GLVALLVA---AIFLCNGSVTLSLCRMYRQQKRHQGSLGPRprtgedevDHLILLALMTVVMAVCSLPL 255
Cdd:pfam00001 155 ISVLGFLLpllVILVCYTLIIRTLRKSASKQKSSERTQRRR--------KALKTLAVVVVVFILCWLPY 215
 
Name Accession Description Interval E-value
7tmA_PGI2 cd15141
prostaglandin I2 receptor, member of the class A family of seven-transmembrane G ...
14-259 1.30e-140

prostaglandin I2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin I2 receptor (also called prostacyclin receptor or prostanoid IP receptor) is a class A, G protein-coupled receptor whose endogenous ligand is prostacyclin, which is the major product of cyclooxygenase metabolite of arachidonic acid that found predominantly in platelets and vascular smooth muscle cells (VSMCs). The PGI2 receptor is coupled to both G(s) and G(q) protein subtypes, resulting in increased cAMP formation, phosphoinositide turnover, and Ca2+ signaling. PGI2 receptor activation by prostacyclin induces VSMC differentiation and produces a potent vasodilation and inhibition of platelet aggregation.


Pssm-ID: 320269 [Multi-domain]  Cd Length: 301  Bit Score: 400.35  E-value: 1.30e-140
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  14 SVGPATSTLMFVAGVVGNGLALGILSARRPAR---PSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLARGgPA 90
Cdd:cd15141    1 DGHPATSTLMFAAGVVGNLLALGILGVHRKERrtkSSAFCVLVTGLAATDLLGTCFLSPMVFVSYAQNSSLLGLAAG-QP 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  91 LCDAFAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWC 170
Cdd:cd15141   80 LCHLFAFAMTFFGLASMLILFAMAVERCLAISHPYFYAQHSGRRLAKLALPAIYAFGALFCALPLLGVGRHKQYCPGTWC 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909 171 FLRMRW---AQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSL------GPRPRTGEDEVDHLILL 241
Cdd:cd15141  160 FIRMTVpghREPGSLAFSLLYASLMALLIAAIFLCNGSVTVSLCRMYRGQKARRGSLrrcgrlGWWLGQGEEEVDHLILL 239
                        250
                 ....*....|....*...
gi 530416909 242 ALMTVVMAVCSLPLTMRG 259
Cdd:cd15141  240 ALMTVIFVVCSLPLTIRA 257
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
14-258 9.04e-99

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 293.38  E-value: 9.04e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  14 SVGPATSTLMFVAGVVGNGLALGILSARRPA-RPSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLlglaRGGPALC 92
Cdd:cd14981    1 GESPAPPALMFVFGVLGNLLALIVLARSSKShKWSVFYRLVAGLAITDLLGILLTSPVVLAVYASNFEW----DGGQPLC 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  93 DAFAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFL 172
Cdd:cd14981   77 DYFGFMMSFFGLSSLLIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALLIASLPLLGLGSYVLQYPGTWCFL 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909 173 RMRWAQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLILLALMTVVMAVCS 252
Cdd:cd14981  157 DFYSKNTGDAAYAYLYSILGLLILLVTLLCNLLVIITLLRMRRRKKRHRRSRRSARRQKRNEIQMVVLLLAITVVFSVCW 236

                 ....*.
gi 530416909 253 LPLTMR 258
Cdd:cd14981  237 LPLMIR 242
7tmA_PGE2_EP2 cd15139
prostaglandin E2 receptor EP2 subtype, member of the class A family of seven-transmembrane G ...
16-258 1.14e-92

prostaglandin E2 receptor EP2 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP2, also called prostanoid EP2 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. Stimulation of the EP2 receptor by PGE2 causes cAMP accumulation through G(s) protein activation, which subsequently produces smooth muscle relaxation and mediates the systemic vasodepressor response to PGE2. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320267 [Multi-domain]  Cd Length: 299  Bit Score: 278.20  E-value: 1.14e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  16 GPATSTLMFVAGVVGNGLALGILSARRPA----RPSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLARGGpAL 91
Cdd:cd15139    3 SPAISALMFSAGVLGNVLALVLLERRRRKevgrRQSLFHVLVTSLVITDLLGTCLISPVVLASYSRNTTLVGMSPNR-LV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  92 CDAFAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCF 171
Cdd:cd15139   82 CGYFGFAMTFFSLATMLILLAMALERCLSIGHPYFYERYVSKRCGYVTIPLIYLLCALFCLFPFLGFGKYVQYCPGTWCF 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909 172 LRMRWAQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGE------DEVDHLILLALMT 245
Cdd:cd15139  162 IDMNPEASEHRAYANLYATLLLLLIVAVVLCNASVIYHLVRMYRRRKRNRSSVGGRARSHRrrfsmaEEVEHLILLVFMT 241
                        250
                 ....*....|...
gi 530416909 246 VVMAVCSLPLTMR 258
Cdd:cd15139  242 IIFVICSLPLTIQ 254
7tmA_PGD2 cd15140
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
20-258 1.23e-65

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor (also called prostanoid DP receptor, DP1, or PGD2R1) is a G-protein coupled receptor whose endogenous ligand is prostaglandin D2 (PGD2). PGD2, the major cyclooxygenase metabolite of arachidonic acid produced by mast cells, mediates inflammatory reactions in response to allergen challenge and causes peripheral vasodilation. PGD2 exerts its biological effects by binding to two types of cell surface receptors: a DP1 receptor that belongs to the prostanoid receptor family and a chemoattractant receptor-homologous molecule expressed on the T-helper type 2 cells (CRTH2 or PD2R2).


Pssm-ID: 320268 [Multi-domain]  Cd Length: 312  Bit Score: 209.75  E-value: 1.23e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  20 STLMFVAGVVGNGLALGIL-------SARRPARP--SAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLARGGP- 89
Cdd:cd15140    7 SSLLFAAGLLGNLLALGLLwlhklhaKKQRGGRPrtSVFYVLVTVLTVTDLLGKCLLSPVVLAAYAQNRSLVGLTPAGNl 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  90 ALCDAFAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSW 169
Cdd:cd15140   87 NLCQVFAFLMIFFGLASTFILLAMALECWLSLGHPFFYQRHINKRLGALVSLILYAFCLGFCALPFFGFGRYVQYCPGTW 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909 170 CFLRM--RWAQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLG--------PRPRT--GEDEVDH 237
Cdd:cd15140  167 CFIQMtaEESSTSALAYSVLYGSLMGLLVLAIVLCNLGIMRNLYQMYRRENEKGIPSTdlqgaaafPRQQEpaGMEELEH 246
                        250       260
                 ....*....|....*....|.
gi 530416909 238 LILLALMTVVMAVCSLPLTMR 258
Cdd:cd15140  247 LILLALMTVLFTACSLPVIAR 267
7tmA_PGE2_EP4 cd15142
prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G ...
17-258 7.06e-58

prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP4, also called prostanoid EP4 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. Like the EP2 receptor, stimulation of the EP4 receptor by PGE2 causes cAMP accumulation through G(s) protein activation. Knockout studies in mice suggest that EP4 receptor may be involved in the maintenance of bone mass and fracture healing. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320270 [Multi-domain]  Cd Length: 302  Bit Score: 189.25  E-value: 7.06e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  17 PATSTLMFVAGVVGNGLALGILS-ARRPARPSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLlglarGGPALCDAF 95
Cdd:cd15142    4 PTIPAVMFIFGVVGNLIAIVVLCkSRKEQKETTFYTLVCGLAVTDLLGTCLASPVTIATYLKGRWP-----GGQPLCEYF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  96 AFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMR 175
Cdd:cd15142   79 SFILLFFSLSGLSIICAMSIERYLAINHAYFYNHYVDKRLAGLTLFAIYASNILFCALPSMGLGKSKLQYPKTWCFIDWR 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909 176 WAQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKR-----------HQGSLGPRPRTGEDEVDHLILLALM 244
Cdd:cd15142  159 TNVSVHAAYSYMYAGFSSLLILVTVLCNVLVCGALIRMHRQFVRrtslgtdqrlsDFRRRRSFRRMAGAEIQMVILLIAT 238
                        250
                 ....*....|....
gi 530416909 245 TVVMAVCSLPLTMR 258
Cdd:cd15142  239 SVVVLICSIPLVVR 252
7tmA_PGE2_EP3 cd15146
prostaglandin E2 receptor EP3 subtype, member of the class A family of seven-transmembrane G ...
14-203 4.00e-26

prostaglandin E2 receptor EP3 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP3, also called prostanoid EP3 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. Stimulation of the EP3 receptor by PGE2 preferentially couples to G(i) protein. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels, which subsequently produces smooth muscle contraction. Knockout mice studies suggest that the EP3 receptor may act as a systemic vasopressor. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320274 [Multi-domain]  Cd Length: 308  Bit Score: 105.73  E-value: 4.00e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  14 SVGPATSTLMFVAGVVGNGLALGILS----ARRPARPSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLARGGp 89
Cdd:cd15146    1 SVSVAFPITMMITGMVGNALAMLLVYrsyrKKENKRKRSFLLCIGSLALTDLFGQLLTSPIVISVYLSDRKWERVDPSG- 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  90 ALCDAFAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSW 169
Cdd:cd15146   80 RLCPFFGLCMTVFGLCPLFIASAMAIERALAIRAPHWYSSHMKTRVTKAVLLGIWLAVLAFALLPIAGVGQYTLQWPGTW 159
                        170       180       190
                 ....*....|....*....|....*....|....
gi 530416909 170 CFLRMRWAQPGGAAFSLAYAGLVALLVAAIFLCN 203
Cdd:cd15146  160 CFISTGDGEPGNNFFASTFASLGLFSLCVTFSCN 193
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
21-255 7.58e-25

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 101.60  E-value: 7.58e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  21 TLMFVAGVVGNGLALGILsARRPARPSAFAVLVTGLAATDLLGTSFLSPAVFVAYarnssLLGLARGGPALCDAFAFAMT 100
Cdd:cd00637    6 ILIFVVGLVGNLLVILVI-LRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSL-----LLGRWWFGDALCKLLGFLQS 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909 101 FFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFlrMRWAQPG 180
Cdd:cd00637   80 VSLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCL--CWPDLTL 157
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530416909 181 GAAFSLAYAGLVALL-VAAIFLCNGSVtlsLCRMYRQQKRHQGSLGPRPRTGEDEVDHLILLALMTVVMA--VCSLPL 255
Cdd:cd00637  158 SKAYTIFLFVLLFLLpLLVIIVCYVRI---FRKLRRHRRRIRSSSSNSSRRRRRRRERKVTKTLLIVVVVflLCWLPY 232
7tmA_TXA2_R cd15143
thromboxane A2 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
15-255 5.87e-23

thromboxane A2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The thromboxane receptor, also known as the prostanoid TP receptor, is a class A G-protein coupled receptor whose endogenous ligand is thromboxane A2 (TXA2). TXA2 is the major product of cyclooxygenase metabolite of arachidonic acid that found predominantly in platelets and stimulates platelet aggregation, Ca2+ influx into platelets, and also causes vasoconstriction. TXA2 has been shown to be involved in immune regulation, angiogenesis and metastasis, among many others. Activation of TXA2 receptor is coupled to G(q) and G(13), resulting in the activations of phospholipase C and RhoGEF, respectively. TXA2 receptor is widely distributed in the body and is abundantly expressed in thymus and spleen.


Pssm-ID: 320271 [Multi-domain]  Cd Length: 296  Bit Score: 96.81  E-value: 5.87e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  15 VGPATSTLMFVAGVVGNGLALGIL-SARRPARP---SAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLARGGpA 90
Cdd:cd15143    2 TSVWFSTIFSAIGLASNLFAFIVLvKSSRKTKSrsrSSFLIFLCGLVVTDFLGLLVTGTIVISFHLTNFNWRVVDPDC-Y 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  91 LCDAFAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWC 170
Cdd:cd15143   81 LCNFMGLSMVFYGLCPLLLGATMAVERFFGINRPFSRSTAMSKRRAWYMVGMVWAFAFLLGLLPILGLGRYTLQYPGSWC 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909 171 FLRMRwAQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQgslgpRPRtgEDEVDHLILLALMTVVMAV 250
Cdd:cd15143  161 FLTLL-FDSKDVAFGLLFSFLGILSVGLSFLLNTVSVVTLCRVYHDRESVQ-----RRR--DSEVEMMVQLLGIMVIASV 232

                 ....*
gi 530416909 251 CSLPL 255
Cdd:cd15143  233 CWLPL 237
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
21-254 7.03e-23

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 96.12  E-value: 7.03e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  21 TLMFVAGVVGNGLALgILSARRPARPSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLArggpaLCDAFAFAMT 100
Cdd:cd14969    8 SLIGVLGVVLNGLVI-IVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDP-----GCVIYGFAVT 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909 101 FFGLASMLILFAMAVERCLALSHPYLYAQLDgPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPG 180
Cdd:cd14969   82 FLGLVSISTLAALAFERYLVIVRPLKAFRLS-KRRALILIAFIWLYGLFWALPPLFGWSSYVPEGGGTSCSVDWYSKDPN 160
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530416909 181 GAAFSLAY-AGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLgPRPRTGEDEVDHLILLALMTVVMAVCSLP 254
Cdd:cd14969  161 SLSYIVSLfVFCFFLPLAIIIFCYYKIYRTLRKMSKRAARRKNSA-ITKRTKKAEKKVAKMVLVMIVAFLIAWTP 234
7tmA_PGE2_EP1 cd15144
prostaglandin E2 receptor EP1 subtype, member of the class A family of seven-transmembrane G ...
16-255 7.38e-23

prostaglandin E2 receptor EP1 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP1, also called prostanoid EP1 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. It has been shown that stimulation of the EP1 receptor by PGE2 causes smooth muscle contraction and increased intracellular Ca2+ levels; however, it is still unclear whether EP1 receptor is exclusively coupled to G(q/11), which leading to activation of phospholipase C and phosphatidylinositol hydrolysis. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320272 [Multi-domain]  Cd Length: 294  Bit Score: 96.38  E-value: 7.38e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  16 GPATSTLMFVAGVVGNGLALGILS---AR-RPARPSAFAVLVTGLAATDLLGtsFLSPAVFVAYARNSSLLGLARGGPAL 91
Cdd:cd15144    3 SPAMPIFSMTLGALSNIVALVILAqsyARfRRRSKATFLLFASSLVLTDLAG--HVIPGALVLRLYLSGQMPAEEPRGAL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  92 CDAFAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCF 171
Cdd:cd15144   81 CQFFGACMVFFGLCPLFLGCAMAVERCVGVTRPLLHSSVVTTTRTKLSLLAIWAVALAVALLPLFRFGRYKPQFPGTWCF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909 172 LRMR----WAQpggAAFSLAYA--GLVALLVAAIflCNgsvTLSLCRMYRQQKRHQGSLGPRpRTGEDEVDHLILLALMT 245
Cdd:cd15144  161 IKVQppgsWAD---VAFALLFSllGLASLLVSLV--CN---TISGLTLVRARLRKKCSCSNR-RAKSHDIEMVVQLVGIM 231
                        250
                 ....*....|
gi 530416909 246 VVMAVCSLPL 255
Cdd:cd15144  232 VVSCICWSPL 241
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
30-255 5.75e-18

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 81.96  E-value: 5.75e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909   30 GNGLALGILSARRPARpSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGlargGPALCDAFAFAMTFFGLASMLI 109
Cdd:pfam00001   1 GNLLVILVILRNKKLR-TPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGDWPF----GSALCKIVGALFVVNGYASILL 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  110 LFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLgLGQHQQYCPGSWCFLRMRWAQPGGAAFSLAYA 189
Cdd:pfam00001  76 LTAISIDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLL-FGWTLTVPEGNVTVCFIDFPEDLSKPVSYTLL 154
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530416909  190 GLVALLVA---AIFLCNGSVTLSLCRMYRQQKRHQGSLGPRprtgedevDHLILLALMTVVMAVCSLPL 255
Cdd:pfam00001 155 ISVLGFLLpllVILVCYTLIIRTLRKSASKQKSSERTQRRR--------KALKTLAVVVVVFILCWLPY 215
7tmA_FP cd15145
prostaglandin F2-alpha receptor, member of the class A family of seven-transmembrane G ...
20-221 4.48e-17

prostaglandin F2-alpha receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The PGF2-alpha receptor, also called prostanoid FP receptor, is a class A G-protein coupled receptor whose endogenous ligand is prostaglandin F2-alpha. PGF2-alpha binding to this receptor is coupled to the stimulation of phospholipase C (PLC) pathway via G-protein subunit G(q). This leads to the release of inositol trisphosphate (IP3) and diacylglycerol (DAG) which results in increased intracellular Ca2+ levels and activation of PKC. The receptor activation primarily induces uterine contraction and bronchoconstriction, and stimulates luteolysis. Like most prostanoid receptors, the PGF2-alpha receptor has also been implicated in tumor angiogenesis and metastasis.


Pssm-ID: 320273 [Multi-domain]  Cd Length: 290  Bit Score: 80.25  E-value: 4.48e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  20 STLMFVAGVVGNGLALGILSAR----RPARPSAFAVLVTGLAATDLLGTSFL-SPAVFVaYARNSSLLGLARGGpALCDA 94
Cdd:cd15145    7 SIIFMTVGILSNSLAIAILMKAyqrfRQKSKASFLLLASGLVITDFFGHLINgTIAVFV-YASDKDWIRFDQSN-ILCSV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  95 FAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRM 174
Cdd:cd15145   85 FGICMVFFGLCPLLLGSVMAVERCIGVTKPIFHSTKMTSKHVKMMLSGVCLFAVLVALLPILGHRDYQIQASRTWCFYKT 164
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 530416909 175 RWAQPGGAAFSL---AYAGLVALLVAaiFLCNGSVTLSLCRMYRQQKRHQ 221
Cdd:cd15145  165 EHIEDWEDRFYLllfSFLGLLALAIS--FLCNAITGITLLRVKFRSQQHR 212
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
17-254 4.16e-12

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 65.75  E-value: 4.16e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  17 PATSTLMFVAGVVGNGLALGILSARRPARpSAFAVLVTGLAATDLLGTSFLsPAVFVAYARnssllglaRGGPALCD--- 93
Cdd:cd14982    4 PIVYSLIFILGLLGNILALWVFLRKMKKR-SPTTIYMINLALADLLFVLTL-PFRIYYYLN--------GGWWPFGDflc 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  94 ---AFAFAMTFFGlaSMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWC 170
Cdd:cd14982   74 rltGLLFYINMYG--SILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASVPLLLLRSTIAKENNSTTC 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909 171 F-LRMRWAQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQgslgPRPRTgedevdhLILLALMTVVMA 249
Cdd:cd14982  152 FeFLSEWLASAAPIVLIALVVGFLIPLLIILVCYSLIIRALRRRSKQSQKSV----RKRKA-------LRMILIVLAVFL 220

                 ....*
gi 530416909 250 VCSLP 254
Cdd:cd14982  221 VCFLP 225
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
21-160 5.27e-11

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 62.29  E-value: 5.27e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  21 TLMFVAGVVGNGLALGILSARRPARPSAfAVLVTGLAATDLLGTSFLSPAVFVayarnSSLLGLARGGPALCDAFAFAMT 100
Cdd:cd15074    8 TVIGILSTLGNGTVLFVLYRRRSKLKPA-ELLTVNLAVSDLGISVFGYPLAII-----SAFAHRWLFGDIGCVFYGFCGF 81
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909 101 FFGLASMLILFAMAVERCLALSHPYLYAQLDGPRcARLALPAIYAFCVLFCALPLLGLGQ 160
Cdd:cd15074   82 LFGCCSINTLTAISIYRYLKICHPPYGPKLSRRH-VCIVIVAIWLYALFWAVAPLVGWGS 140
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
22-157 6.95e-11

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 61.97  E-value: 6.95e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  22 LMFVAGVVGNGLALGILSARRPARPSAFaVLVTGLAATDLLgTSFLSPAVFVAyarnSSLLGLARGGPALCDAFAFAMTF 101
Cdd:cd15083    9 IIGLIGVVGNGLVIYAFCRFKSLRTPAN-YLIINLAISDFL-MCILNCPLMVI----SSFSGRWIFGKTGCDMYGFSGGL 82
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 530416909 102 FGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLG 157
Cdd:cd15083   83 FGIMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVLPPLFG 138
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
20-254 1.09e-09

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 58.80  E-value: 1.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  20 STLMFVAGVVGNGLALGILSaRRPARPSAFAVLvTGLAATDLL-GTSFLSPAVFVAYARNSSLLglARGGPALCDAFAFA 98
Cdd:cd14978    7 LPVICIFGIIGNILNLVVLT-RKSMRSSTNVYL-AALAVSDILvLLSALPLFLLPYIADYSSSF--LSYFYAYFLPYIYP 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  99 MTFFGL-ASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWA 177
Cdd:cd14978   83 LANTFQtASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENCNNNSYYYVIPT 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909 178 QPGGAAFSL------AYAGLVALL-VAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLILLALMTVVMAV 250
Cdd:cd14978  163 LLRQNETYLlkyyfwLYAIFVVLLpFILLLILNILLIRALRKSKKRRRLLRRRRRLLSRSQRRERRTTIMLIAVVIVFLI 242

                 ....
gi 530416909 251 CSLP 254
Cdd:cd14978  243 CNLP 246
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
22-170 2.07e-09

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 57.57  E-value: 2.07e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  22 LMFVAGVVGNGLALGILSARRPARpSAFAVLVTGLAATDLLgTSFLSPAVFVAYarnsSLLGLARGGPALCDAFAFAMTF 101
Cdd:cd14967    8 LIILVTVFGNLLVILAVYRNRRLR-TVTNYFIVSLAVADLL-VALLVMPFSAVY----TLLGYWPFGPVLCRFWIALDVL 81
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530416909 102 FGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYaFCVLFCALPLLGLGQHQQYCPGSWC 170
Cdd:cd14967   82 CCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVW-VYSLLISLPPLVGWRDETQPSVVDC 149
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
18-157 4.20e-09

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 56.50  E-value: 4.20e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  18 ATSTLMFVA-GVVGNGLALGILsARRPARPSAFAVLVTGLAATDLLGTSFLSPAVFVAYarnssLLGLARGGPALCDAFA 96
Cdd:cd15210    4 AVWGIVFMVvGVPGNLLTVLAL-LRSKKLRTRTNAFIINLSISDLLFCAFNLPLAASTF-----LHQAWIHGETLCRVFP 77
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530416909  97 FAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLG 157
Cdd:cd15210   78 LLRYGLVAVSLLTLVLITLNRYILIAHPSLYPRIYTRRGLALMIAGTWIFSFGSFLPLWLG 138
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
20-170 6.90e-09

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 55.90  E-value: 6.90e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  20 STLMFVAGV---VGNGLALGILSARRPARPSAFAVLVTgLAATDLLGTSFLSPavfvaYARNSSLLGLARGGPALCDAFA 96
Cdd:cd15073    4 AAYLIVAGIistISNGIVLVTFVKFRELRTPTNALIIN-LAVTDLGVSIIGYP-----FSAASDLHGSWKFGYAGCQWYA 77
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530416909  97 FAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALpAIYAFCVLFCALPLLGLGQHQQYCPGSWC 170
Cdd:cd15073   78 FLNIFFGMASIGLLTVVAVDRYLTICRPDLGRKMTTNTYTVMIL-LAWTNAFFWAAMPLVGWASYALDPTGATC 150
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
17-220 9.95e-09

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 55.46  E-value: 9.95e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  17 PATSTLMFVAGVVGNGLALGILSARRPARPSAfAVLVTGLAATDLlgtsflspaVFVA----YARNSSLLGLARGGPALC 92
Cdd:cd14985    4 PALYIAIFLVGLLGNLFVVWVFLFPRGPKRVA-DIFIANLAAADL---------VFVLtlplWATYTANQYDWPFGAFLC 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  93 DAFAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFcALPLLGLGQHQ--QYCPGSWC 170
Cdd:cd14985   74 KVSSYVISVNMFASIFLLTCMSVDRYLAIVHPVASRRLRRRRQARVTCALIWVVACLL-SLPTFLLRSLQaiENLNKTAC 152
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 530416909 171 -FLRMRWAQPGGAAFSLAYAGLVALLVAAIFlCNGSVTLSLCRMYRQQKRH 220
Cdd:cd14985  153 iMLYPHEAWHFGLSLELNILGFVLPLLIILT-CYFHIARSLRKRYERTGKN 202
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
21-223 2.08e-08

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 54.75  E-value: 2.08e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  21 TLMFVAGVVGNGLALGILSARRPARpSAFAVLVTGLAATDLLGTSFLsPAVFVAYARNssllGLARGGPALCDAFAFAMT 100
Cdd:cd15158    8 SVITVFGLVGNGFALYVLIKTYRQK-SAFHIYMLNLAVSDLLCVCTL-PLRVVYYVHK----GQWLFGDFLCRISSYALY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909 101 FFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCAlPLLGLGQHQQYCPGSWCFLRMRWAQPG 180
Cdd:cd15158   82 VNLYCSIYFMTAMSFTRFLAIVFPVQNLNLVTVKKARIVCVGIWIFVTLTSS-PFLMSGSHDTETNKTKCFEPPQSNQQL 160
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 530416909 181 GAAFSLAYAGLV---ALLVAAIFLCNGSVTLSLCRMYRQQKRHQGS 223
Cdd:cd15158  161 TKLLVLNYISLVvgfIIPFLVILICYAMIIRTLLKNTMKARKQQSS 206
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
28-258 2.28e-08

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 54.61  E-value: 2.28e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  28 VVGNGLAL-GILSARRPARPsaFAVLVTGLAATDLL-GTSFLSPAVFVayarnsslLGLARGGPALCDAFAFAMTFF-GL 104
Cdd:cd14972   13 VVENSLVLaAIIKNRRLHKP--MYILIANLAAADLLaGIAFVFTFLSV--------LLVSLTPSPATWLLRKGSLVLsLL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909 105 ASMLILFAMAVERCLALSHPYLY-AQLDGPRCaRLALPAIYAFCVLFCALPLLglgqhqqycpGSWCFLRMRWA-QPGGA 182
Cdd:cd14972   83 ASAYSLLAIAVDRYISIVHGLTYvNNVTNKRV-KVLIALVWVWSVLLALLPVL----------GWNCVLCDQEScSPLGP 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909 183 AFSLAYA----GLVALLVAAIFLCNGSVTLSLCR-MYRQQKRHQGSLGPRPRTgedEVDHLILLALMTVVMAVCSLPLTM 257
Cdd:cd14972  152 GLPKSYLvlilVFFFIALVIIVFLYVRIFWCLWRhANAIAARQEAAVPAQPST---SRKLAKTVVIVLGVFLVCWLPLLI 228

                 .
gi 530416909 258 R 258
Cdd:cd14972  229 L 229
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
15-225 2.71e-08

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 54.42  E-value: 2.71e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  15 VGPATSTLMFVAGVVGNGLAL-GILSARRPARPSAFAVLVTGLAATDllGTSFLSPAVFVAY-ARNSSLLGLArggpaLC 92
Cdd:cd15122    2 TGTIFLLLAALLGLPGNGFIIwSILWKMKARGRSVTCILILNLAVAD--GAVLLLTPFFITFlTRKTWPFGQA-----VC 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  93 DAFAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFcALPLLGLGQHQQYCPGSWCFL 172
Cdd:cd15122   75 KAVYYLCCLSMYASIFIIGLMSLDRCLAVTRPYLAQSLRKKALVRKILLAIWLLALLL-ALPAFVYRHVWKDEGMNDRIC 153
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 530416909 173 RMRWAQPGGAAFSLAYAGLVALLVAAIFLCnGSVTLSLCRMYRQQKRHQGSLG 225
Cdd:cd15122  154 EPCHASRGHAIFHYTFETLVAFVLPFGVIL-FSYSVILVRLKGARFRRRARVE 205
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
17-254 3.31e-08

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 53.95  E-value: 3.31e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  17 PATSTLMFVAGVVGNGLALGIL-SARRPARPSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLarggpALCDAF 95
Cdd:cd15002    3 PILLGVICLLGFAGNLMVIGILlNNARKGKPSLIDSLILNLSAADLLLLLFSVPFRAAAYSKGSWPLGW-----FVCKTA 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  96 AFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALpaiyAFCVLFCALPL-----LGLGQHQQycpGSWC 170
Cdd:cd15002   78 DWFGHACMAAKSFTIAVLAKACYMYVVNPTKQVTIKQRRITAVVA----SIWVPACLLPLpqwlfRTVKQSEG---VYLC 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909 171 FLRMRW-AQPGGAAFSLAYAGLVALL-VAAIFLCNGsvtlslcRMYRQQKRhQGSLGPRPRTGEDEVDHLILLALMTVVM 248
Cdd:cd15002  151 ILCIPPlAHEFMSAFVKLYPLFVFCLpLTFALFYFW-------RAYGQCQR-RGTKTQNLRNQIRSRKLTHMLLSVVLAF 222

                 ....*.
gi 530416909 249 AVCSLP 254
Cdd:cd15002  223 TILWLP 228
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
17-254 5.36e-08

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 53.58  E-value: 5.36e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  17 PATSTLMFVAGVVGNGLALGILSARRPARP-SAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLArggpaLCDAF 95
Cdd:cd15098    4 PVVFGLIFCLGVLGNSLVITVLARVKPGKRrSTTNVFILNLSIADLFFLLFCVPFQATIYSLPEWVFGAF-----MCKFV 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  96 AFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCvLFCALPLL---GLGQHQQYCPGSWCF- 171
Cdd:cd15098   79 HYFFTVSMLVSIFTLVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVLS-LAMASPVAvhqDLVHHWTASNQTFCWe 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909 172 -LRMRWAQPGGAAFSLAYAGLVALLVaaIFLCNGSVTLSLCRMYRqqkrhqgSLGPRPRTGEDEVDHLILlaLMTVVMAV 250
Cdd:cd15098  158 nWPEKQQKPVYVVCTFVFGYLLPLLL--ITFCYAKVLNHLHKKLK-------NMSKKSERSKKKTAQTVL--VVVVVFGI 226

                 ....
gi 530416909 251 CSLP 254
Cdd:cd15098  227 SWLP 230
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
21-257 2.69e-07

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 51.45  E-value: 2.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  21 TLMFVAGVVGNGLALgILSARRPARPSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGlarggPALCDAFAFAMT 100
Cdd:cd15203    8 GLIIVLGVVGNLLVI-YVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPFTLIYTLTKNWPFG-----SILCKLVPSLQG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909 101 FFGLASMLILFAMAVERCLALSHPyLYAQLdGPRCARLALPAIYAFCVLfCALPLL------GLGQHQQYCPGSWCFLRm 174
Cdd:cd15203   82 VSIFVSTLTLTAIAIDRYQLIVYP-TRPRM-SKRHALLIIALIWILSLL-LSLPLAifqelsDVPIEILPYCGYFCTES- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909 175 rWAQPGgaaFSLAYAGLVALL-----VAAIFLCNGSVTLSL--------CRMYRQQKRHQGSLGPRPRTgedevdhLILL 241
Cdd:cd15203  158 -WPSSS---SRLIYTISVLVLqfvipLLIISFCYFRISLKLrkrvkkkrGKRTLSSRRRRSELRRKRRT-------NRLL 226
                        250
                 ....*....|....*.
gi 530416909 242 ALMTVVMAVCSLPLTM 257
Cdd:cd15203  227 IAMVVVFAVCWLPLNL 242
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
21-157 2.71e-07

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 51.42  E-value: 2.71e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  21 TLMFVAGVVGNGLALGILSARRPAR-PSAfaVLVTGLAATDLLGTSFLSPAVFvayarnSSLLGLARGGPALCDAFAFAM 99
Cdd:cd15079    8 IFLGIVSLLGNGLVIYIFSTTKSLRtPSN--MLVVNLAISDFLMMIKMPIFIY------NSFYEGWALGPLGCQIYAFLG 79
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530416909 100 TFFGLASMLILFAMAVERCLALSHPylyaqLDGPRCAR----LALPAIYAFCVLFCALPLLG 157
Cdd:cd15079   80 SLSGIGSIWTNAAIAYDRYNVIVKP-----LNGNPLTRgkalLLILFIWLYALPWALLPLLF 136
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
17-171 2.71e-07

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 51.35  E-value: 2.71e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  17 PATSTLMFVAGVVGNGLALGILSARRPARpSAFAVLVTGLAATDLLGTSFLsPAVFVAYARNSSLLGlargGPALCDAFA 96
Cdd:cd15921    4 PTAYILIFILGLTGNSISVYVFLSQYRSQ-TPVSVLMVNLAISDLLLVCTL-PLRLTYYVLNSHWPF----GDIACRIIL 77
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530416909  97 FAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCAlPLLGLGQHQQYCPGSWCF 171
Cdd:cd15921   78 YVLYVNMYSSIYFLTALSVFRYLALVWPYLYLRVQTHSVAGIICGLIWILMGLASS-PLLFAKSKQHDEGSTRCL 151
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
17-224 3.26e-07

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 51.01  E-value: 3.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  17 PATSTLMFVAGVVGNGLALGILSARRPARpSAFAVLVTGLAATDllgtsFLSPAVFVAYARNSSLLGLARGGPALCDAFA 96
Cdd:cd15194    4 PILYCLVFLVGAVGNAILMGALVFKRGVR-RLIDIFISNLAASD-----FIFLVTLPLWVDKEVVLGPWRSGSFLCKGSS 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  97 FAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFcALPLLGLGQHQQYCPGSWCflrmrw 176
Cdd:cd15194   78 YIISVNMYCSVFLLTCMSLDRYLAIVLPLVSRKFRTKHNAKVCCTCVWMLSCLL-GLPTLLSRELKKYEEKEYC------ 150
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 530416909 177 AQPGGAAFSLAYAgLVALLVA------AIFLCNGSVTLSLCRMYRQQKRHQGSL 224
Cdd:cd15194  151 NEDAGTPSKVIFS-LVSLIVAfflpllSILTCYCTIIWKLCHHYQKSGKHQKKL 203
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
17-156 3.67e-07

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 50.90  E-value: 3.67e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  17 PATSTLMFVAGVVGNGLALGILSARRPARPSafAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLglargGPALCDAFA 96
Cdd:cd15372    4 PSLYTLVFLVGLPANGLALWVLATQVKRLPS--TIFLINLAVADLLLILVLPFKISYHFLGNNWPF-----GEGLCRVVT 76
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  97 FAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYaFCVLFCALPLL 156
Cdd:cd15372   77 AFFYGNMYCSVLLLMCISLDRYLAVVHPFFARTLRSRRFALCMCTAIW-LIAAALTLPLT 135
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
22-255 7.31e-07

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 49.91  E-value: 7.31e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  22 LMFVAGVVGNGLALGILSARRPARPSAFAVLVTgLAATDLLGTSFLSPAVFVAYARNSSLLGlarggPALCDAFAFAMTF 101
Cdd:cd14993    9 VVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVN-LAVADLLVSLFCMPLTLLENVYRPWVFG-----EVLCKAVPYLQGV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909 102 FGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFcVLFCALPLL------------GLGQHQQYCPGSW 169
Cdd:cd14993   83 SVSASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVI-AIIIMLPLLvvyeleeiissePGTITIYICTEDW 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909 170 CFLRMRWAQpGGAAFSLAYagLVALLVaaIFLCNGSVTLSLCRmyRQQKRHQGSLGPRPRTGEDEVDHLILLALMTVVM- 248
Cdd:cd14993  162 PSPELRKAY-NVALFVVLY--VLPLLI--ISVAYSLIGRRLWR--RKPPGDRGSANSTSSRRILRSKKKVARMLIVVVVl 234

                 ....*...
gi 530416909 249 -AVCSLPL 255
Cdd:cd14993  235 fALSWLPY 242
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
22-254 8.83e-07

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 49.79  E-value: 8.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  22 LMFVAGVVGNGLAL-GILSARRPARPSAfaVLVTGLAATDLLgTSFLSPAVFVAYARNSSLLGlarggPALCDAFAFAMT 100
Cdd:cd14975    9 LAFAIGLPGNSFVIwSILIKVKQRSVTM--LLVLNLALADLA-VLLTLPVWIYFLATGTWDFG-----LAACKGCVYVCA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909 101 FFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFcALPLLGLGQHQQYCPGSWCFlrMRWAQPG 180
Cdd:cd14975   81 VSMYASVFLITLMSLERFLAVSRPFVSQGWRAKALAHKVLAIIWLLAVLL-ATPVIAFRHVEETVENGMCK--YRHYSDG 157
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530416909 181 GAAFSLAYAGLVALLV--AAIFLCNGSVTLSLCRMYRQQKRhqgslgprpRTGEdevdhliLLALMTVVMAVCSLP 254
Cdd:cd14975  158 QLVFHLLLETVVGFAVpfTAVVLCYSCLLRRLRRRRFRRRR---------RTGR-------LIASVVVAFAACWLP 217
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
17-160 2.38e-06

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 48.21  E-value: 2.38e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  17 PATSTLMFVAGVVGNGLALGILSARRPARPSAfAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGlarggPALCDAFA 96
Cdd:cd15162    4 PAVYTLVFVVGLPANGMALWVLLFRTKKKAPA-VIYMANLAIADLLLVIWLPFKIAYHIHGNNWIFG-----EALCRLVT 77
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530416909  97 FAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFcVLFCALPLLGLGQ 160
Cdd:cd15162   78 VAFYGNMYCSILLLTCISIDRYLAIVHPMGHRRLRARRYALGTCLAIWLL-ALLVTLPLYLVKQ 140
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
15-254 3.41e-06

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 48.05  E-value: 3.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  15 VGPATSTLMFVAGVVGNGLALGILSARRPARpSAFAVLVTGLAATDLlgtSFL-SPAVFVA--YARNSSLLGLarggpAL 91
Cdd:cd15095    2 LVPLIFAIIFLVGLAGNSLVIYVVSRHREMR-TVTNYYIVNLAVTDL---AFLvCCVPFTAalYATPSWVFGD-----FM 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  92 CDAFAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCF 171
Cdd:cd15095   73 CKFVNYMMQVTVQATCLTLTALSVDRYYAIVHPIRSLRFRTPRVAVVVSACIWIVSFLLSIPVAIYYRLEEGYWYGPQTY 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909 172 LRMRWAQPggaAFSLAYAGLVALLV-----AAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLILlalmTV 246
Cdd:cd15095  153 CREVWPSK---AFQKAYMIYTVLLTyviplAIIAVCYGLILRRLWRRSVDGNNQSEQLSERALRQKRKVTRMVI----VV 225
                        250
                 ....*....|
gi 530416909 247 VM--AVCSLP 254
Cdd:cd15095  226 VVlfAICWLP 235
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
17-152 3.64e-06

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 47.90  E-value: 3.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  17 PATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLglargGPALCDAFA 96
Cdd:cd15097    4 PVVFSLIFLLGTVGNSLVLAVLLRSGQSGHNTTNLFILNLSVADLCFILFCVPFQATIYSLEGWVF-----GSFLCKAVH 78
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 530416909  97 FAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCA 152
Cdd:cd15097   79 FFIYLTMYASSFTLAAVSVDRYLAIRYPLRSRELRTPRNAVAAIALIWGLSLLFAG 134
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
18-163 3.74e-06

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 47.76  E-value: 3.74e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  18 ATSTLMFVAGVVGNGLALGILSARRPARpSAFAVLVTGLAATDLLGTSF--LSPAVFVAYARnssllglARGGPALCDAF 95
Cdd:cd14986    5 AVLGVLFVFTLVGNGLVILVLRRKRKKR-SRVNIFILNLAIADLVVAFFtvLTQIIWEATGE-------WVAGDVLCRIV 76
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530416909  96 AFAMTFFGLASMLILFAMAVERCLALSHPylYAQLDGPRCARLALPAIYAFCVLFcALPLLGLGQHQQ 163
Cdd:cd14986   77 KYLQVVGLFASTYILVSMSLDRYQAIVKP--MSSLKPRKRARLMIVVAWVLSFLF-SIPQLVIFVERE 141
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
23-154 1.10e-05

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 46.54  E-value: 1.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  23 MFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATDLLGTSFLSP-----AVFVAYarnssllglaRGGPALCDAFAF 97
Cdd:cd15382   10 LFLIAAVGNLTVLLILLRNRRRKRSRVNILLMHLAIADLLVTFIMMPleigwAATVAW----------LAGDFLCRLMLF 79
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 530416909  98 aMTFFGLA-SMLILFAMAVERCLALSHPyLYAqLDGPRCARLALPAIYAFCVLfCALP 154
Cdd:cd15382   80 -FRAFGLYlSSFVLVCISLDRYFAILKP-LRL-SDARRRGRIMLAVAWVISFL-CSIP 133
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
15-255 1.21e-05

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 46.13  E-value: 1.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  15 VGPATSTLMFVAGVVGNGLALGILSARRPARpSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLArggpaLCDA 94
Cdd:cd15096    2 VVPVIFGLIFIVGLIGNSLVILVVLSNQQMR-STTNILILNLAVADLLFVVFCVPFTATDYVLPTWPFGDV-----WCKI 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  95 FAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFcVLFCALPLLGLGQHQQY----CPGSWC 170
Cdd:cd15096   76 VQYLVYVTAYASVYTLVLMSLDRYLAVVHPITSMSIRTERNTLIAIVGIWIV-ILVANIPVLFLHGVVSYgfssEAYSYC 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909 171 flRMRWAQPGGAA------FSLAYagLVALLVaaiflcngSVTLSLCRMYR--QQKRHQGSLGPRPRTGEDEVDHLILLA 242
Cdd:cd15096  155 --TFLTEVGTAAQtfftsfFLFSY--LIPLTL--------ICVLYMLMLRRlrRQKSPGGRRSAESQRGKRRVTRLVVVV 222
                        250
                 ....*....|...
gi 530416909 243 LmtVVMAVCSLPL 255
Cdd:cd15096  223 V--VVFAICWLPI 233
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
25-157 1.65e-05

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 45.86  E-value: 1.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  25 VAGVVGNGLALGILSARRPARPSAfAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGlarggPALCDAFAFAMTFFGL 104
Cdd:cd15336   12 ITGMLGNALVIYAFCRSKKLRTPA-NYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFG-----EKGCELYAFCGALFGI 85
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 530416909 105 ASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLG 157
Cdd:cd15336   86 TSMITLLAISLDRYLVITKPLASIRWVSKKRAMIIILLVWLYSLAWSLPPLFG 138
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
21-155 1.66e-05

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 45.79  E-value: 1.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  21 TLMFVAGVVGNGLA-LGILSARRPARPSAFavLVTGLAATDLL-GTSFLSPAVFVAYARNSSLlglargGPALCDAFAFA 98
Cdd:cd15051    8 AVIILLTVIGNVLVcLAVAVNRRLRNLTNY--FIVSLAVTDLLlGLLVLPFSAIYELRGEWPL------GPVFCNIYISL 79
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 530416909  99 MTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPL 155
Cdd:cd15051   80 DVMLCTASILNLFAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWVVSLAVSFLPI 136
7tmA_Mrgpr cd14973
mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G ...
25-255 1.74e-05

mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined. Also included in this family is Mas-related G-protein coupled receptor 1-like (MAS1L) which is only found in primates. The angiotensin-II metabolite angiotensin is an endogenous ligand for MAS1L.


Pssm-ID: 320104 [Multi-domain]  Cd Length: 272  Bit Score: 45.71  E-value: 1.74e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  25 VAGVVGNGLALGILSARRPARPsaFAVLVTGLAATDLLgtsFLSPAVFVAYArnsSLLGLARGGPALCDAFAFAMTFFGL 104
Cdd:cd14973   12 LCGLVGNGLVLWLLGFRIKRNP--FSVYILNLAAADFL---FLSCQAIQSLE---DLLGGSLPGFALCRLLATLMFFSYT 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909 105 ASMLILFAMAVERCLALSHPYLYaqldgpRCAR-LALPA-----IYAFCVLFCALPLLGLGQHQQYCPGSWCFlrmrwaq 178
Cdd:cd14973   84 VGLSLLAAISTERCLSVLFPIWY------RCHRpKHLSAvvcalLWALSLLLSVLESYFCGFLFWKFNESACR------- 150
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530416909 179 pggaAFSLAYAGLVALLVaaIFLCNGSVTLSLcrmyRQQKRHQgslgPRPRTGedevdhLILLALMTVVM-AVCSLPL 255
Cdd:cd14973  151 ----TFNFLSALLFLLLF--LVMCVSSLTLLI----RVQCSSQ----RRPPTR------LYVVILLTVLVfLLCGLPL 208
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
18-163 3.14e-05

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 45.04  E-value: 3.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  18 ATSTLMFVAGVVGNGLALgILSARRPARPSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGlargGPALCDAFAF 97
Cdd:cd14979    5 AIYVAIFVVGIVGNLLTC-IVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWWQYPWAF----GDGGCKLYYF 79
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530416909  98 AMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLfCALPLLGLGQHQQ 163
Cdd:cd14979   80 LFEACTYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSIL-CAIPILFLMGIQY 144
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
20-297 3.19e-05

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 44.84  E-value: 3.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  20 STLMFVAGV--VGNGLALGILSARRPARPSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGlarggPALCDAFAF 97
Cdd:cd15085    4 SFLMFLNATfsIFNNVLVIAVTLKNPQLRNPINIFILNLSFSDLMMALCGTTIVTVTNYEGYFYLG-----DAFCIFQGF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  98 AMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLaLPAIYAFCVLFCALPLLGLgqhQQYCP-GSWCFLRMRW 176
Cdd:cd15085   79 AVNYFGIVSLWSLTLLAYERYNVVCKPMGGLKLSTKRGYQG-LLFIWLFCLFWAVAPLFGW---SSYGPeGVQTSCSIGW 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909 177 AQPGGAAFS---LAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPrprtgEDEVDHLILLALMTVVMAVCSL 253
Cdd:cd15085  155 EERSWSNYSyliLYFLMCFVIPVAIIGFSYGNVLRSLHKLNKKIEQQGGKNCP-----EEEERAVIMVLAMVIAFLICWL 229
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 530416909 254 PLTmrgsVFrpvtqSQVLVLGPSIVEPDLP---PTWLPSASEQAPPL 297
Cdd:cd15085  230 PYT----VF-----ALIVVVNPELSISPLAatmPTYFAKTSPVYNPI 267
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
18-156 3.83e-05

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 44.77  E-value: 3.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  18 ATSTLMFVAGVVGNGLALGILSARRPARpSAFAVLVTGLAATDLLGTSFLSPavfVAYARNSSLLGLarGGPALCDAFAF 97
Cdd:cd15205    5 ITYVLIFVLALFGNSLVIYVVTRKRAMR-TATNIFICSLALSDLLITFFCIP---FTLLQNISSNWL--GGAFMCKMVPF 78
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 530416909  98 AMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFcALPLL 156
Cdd:cd15205   79 VQSTAVVTSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGLVWIVSVIV-GSPML 136
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
17-159 1.80e-04

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 42.78  E-value: 1.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  17 PATSTLMFVAGVVGNGLALGILsARRPARPSAFAVLVTGLAATDLLgtsFLSPAVFVA--YARNSSLLglarGGPALCDA 94
Cdd:cd15157    4 PTVYLIIFVLGVVGNGLSIYVF-LQPSKKKTSVNIFMLNLAVSDLM---FVSTLPFRAdyYLMGSHWV----FGDIACRI 75
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530416909  95 FAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFcVLFCALPLLGLG 159
Cdd:cd15157   76 MSYSLYVNMYCSIYFLTVLSIVRFLAIVHPFKLWKVTSIKYARILCAVIWIF-VMAASSPLLSKG 139
7tmA_Retinal_GPR cd15072
retinal G protein coupled receptor, member of the class A family of seven-transmembrane G ...
18-159 2.03e-04

retinal G protein coupled receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the retinal G-protein coupled receptor (RGR) found exclusively in retinal pigment epithelium (RPE) and Muller cells. RGR is a member of the class A rhodopsin-like receptor family. As with other opsins, RGR binds all-trans retinal and contains a conserved lysine reside on the seventh helix. RGR functions as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Two mutations in RGR gene are found in patients with retinitis pigmentosa, indicating that RGR is essential to the visual process.


Pssm-ID: 320200 [Multi-domain]  Cd Length: 260  Bit Score: 42.35  E-value: 2.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  18 ATSTLMFVAGVVG---NGLALGILSARRP-ARPSAFAVLVTGLAATDLLGTSFLspavfvayARNSSLLGLARGGPALCD 93
Cdd:cd15072    2 AVGSILLVEALVGfslNGLTILSFCKTRElRTPSNLLVLSLAVADMGISLNALV--------AASSSLLRRWPYGSEGCQ 73
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530416909  94 AFAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQldgpRCARLALPAIYAFCVLFCALPLLGLG 159
Cdd:cd15072   74 AHGFQGFFTALASICSSAAIAWDRYHHYCTRSKLQW----STAISLVLFVWLFSAFWAAMPLLGWG 135
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
18-159 2.56e-04

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 42.44  E-value: 2.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  18 ATSTLMFVAGVVGNGL-ALGILSARRPARPSAFAVLvtGLAATDLLGTSFLSPAVFVAYARNSSllglARGGPALCDAFA 96
Cdd:cd15005    5 TTLGLILCVSLAGNLLfSVLIVRDRSLHRAPYYFLL--DLCLADGLRSLACFPFVMASVRHGSG----WIYGALSCKVIA 78
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530416909  97 FAMTFFGLASMLILFAMAVERCLALSHPYLYAQ-LDGPRCARLALpAIYAFCVLFCALPLLGLG 159
Cdd:cd15005   79 FLAVLFCFHSAFTLFCIAVTRYMAIAHHRFYAKrMTFWTCLAVIC-MAWTLSVAMAFPPVFDVG 141
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
22-219 2.58e-04

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 42.00  E-value: 2.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  22 LMFVAGVVGNGLALGILSARRPARpSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLArggPALCDAFAFAMTF 101
Cdd:cd15161    9 LVFILAFPGNTLALWLFIHDRKSG-TPSNVFLMHLAVADLSYVLILPMRLVYHLSGNHWPFGEV---PCRLAGFLFYLNM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909 102 FglASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFcVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPGG 181
Cdd:cd15161   85 Y--ASLYFLACISVDRFLAIVHPVKSMKIRKPLYAHVVCGFLWVI-VTVAMAPLLVSPQTVEVNNTTVCLQLYREKASRG 161
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 530416909 182 AAFSLAYAGLVALLVaaIFLCNGSVTLSLCRMYRQQKR 219
Cdd:cd15161  162 ALVSLAVAFTIPFVT--TVTCYLLIIRSLRTGKREEKP 197
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
28-157 3.23e-04

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 41.84  E-value: 3.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  28 VVGNGLALGILSARRPARPSAFAVLVTGLAATDLL-GTSFLSPAVFVAYARNSSLLGLA---RGgpALCDAFAFAMTFFG 103
Cdd:cd14980   15 LIGNILVIIWHISSKKKKKKVPKLLIINLAIADFLmGIYLLIIAIADQYYRGRYAQYSEewlRS--PPCLLACFLVSLSS 92
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 530416909 104 LASMLILFAMAVERCLALSHPYLYAQLdGPRCARLALPAIYAFCVLFCALPLLG 157
Cdd:cd14980   93 LMSVLMMLLITLDRYICIVYPFSNKRL-SYKSAKIILILGWLFSIIFAAIPILY 145
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
18-223 3.58e-04

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 41.67  E-value: 3.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  18 ATSTLMFVAGVVGNGLALGILSARrPARPSAFAVLVTGLAATDLLGTSFLsPAVFVAYARNSSllglarGGPALCDaFAF 97
Cdd:cd15923    5 AIYIPTFVLGLLLNILALWVFCWR-LKKWTETNIYMTNLAVADLLLLISL-PFKMHSYRRESA------GLQKLCN-FVL 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  98 AMTFFGL-ASMLILFAMAVERCLALSHPYLYAQLDGPRCArLALPAIYAFCVLFCALPLLGLGQHQQycpGSWCFLRMRW 176
Cdd:cd15923   76 SLYYINMyVSIFTITAISVDRYVAIRYPLRARELRSPRKA-AVVCAVIWVLVVTISIPYFLLDSSNE---KTMCFQRTKQ 151
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 530416909 177 AQPGGAAFSLAYAGLVALLVAAIFlCNGSVTLSLcrmyRQQKRHQGS 223
Cdd:cd15923  152 TESLKVFLLLEIFGFLLPLIIMTF-CSARVIHTL----QKRLDDVGS 193
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
21-290 3.91e-04

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 41.68  E-value: 3.91e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  21 TLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATDLLGTSFlsPAVFVAYARNSsllgLARGGPALCDAFAFAMT 100
Cdd:cd15200    8 GIEFVLGLVGNGIALFIFCFHRRPWKSNTMYLLSLVVADFFLIINL--PFRIDYYLRNE----VWRFGATACQVNLFMLS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909 101 FFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLF-CALPLLGLGQH----QQYCPGSWCFLRMR 175
Cdd:cd15200   82 MNRTASIVFLTAIALNRYLKVVHPHHQLSKASVGCAAKVAAGLWILILLLnIHLLLLDHVQSnstcLSYDHGTDPSASDR 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909 176 WAQpggaafslayaglvALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGedevdhLILLALMTVVMAVCSLP- 254
Cdd:cd15200  162 WHR--------------ILFFLEFFLPLGIILFCIFSIILTLKQRKLAKQAGPQRA------VKVLAVIVLVYTVCFLPs 221
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 530416909 255 --LTMRGSVFRPVTQSQVLVLGPSIVEPDLPPTWLPSA 290
Cdd:cd15200  222 ilFALASLVAFKVSQCRSLDLCTQLFHGSLAFTYLNSA 259
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
17-254 4.32e-04

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 41.53  E-value: 4.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  17 PATSTLMFVAGVVGNGLALGILSaRRPARPSAFAVLVTGLAATDLLgTSFLSPAVFVAYARNSSLLGlargGPALCDAFA 96
Cdd:cd15168    4 PIVYGVVFLVGLLLNSVVLYRFI-FHLKPWNSSAIYMFNLAVSDLL-YLLSLPFLIYYYANGDHWIF----GDFMCKLVR 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  97 FAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFcVLFCALPLLGLGQHQQYCPGSWCFlrmRW 176
Cdd:cd15168   78 FLFYFNLYGSILFLTCISVHRYLGICHPLRSLGKLKKRHAVAISVAVWIL-VLLQLLPILFFATTGRKNNRTTCY---DT 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909 177 AQPGGAAFSLAYAGLVALL-----VAAIFLCNGSVTLSLCRmyrqQKRHQGSLGPRPRTgedevdhLILLALMTVVMAVC 251
Cdd:cd15168  154 TSPEELNDYVIYSMVLTGLgfllpLLIILACYGLIVRALIR----KLGEGVTSALRRKS-------IRLVIIVLALFAVC 222

                 ...
gi 530416909 252 SLP 254
Cdd:cd15168  223 FLP 225
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
17-155 4.78e-04

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 41.22  E-value: 4.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  17 PATSTLMFVAGVVGNGLALGiLSARRPARPSAFAVLVTGLAATDLLGTSFLSpaVFVAYARNSSLLGLargGPALCDAFA 96
Cdd:cd15160    4 PVVYSFVFVVGLPANCLALW-VLYLQIKKENVLGVYLLNLSLSDLLYILTLP--LWIDYTANHHNWTF---GPLSCKVVG 77
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 530416909  97 FAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPL 155
Cdd:cd15160   78 FFFYTNIYASIGFLCCIAVDRYLAVVHPLRFRGLRTRRFALKVSASIWVLELGTHSVFL 136
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
18-168 4.93e-04

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 41.36  E-value: 4.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  18 ATSTLMFVAGVVGNGLALGILsARRPARPSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGlargGPALCDAFAF 97
Cdd:cd15133    5 LTYLLIFVVGVVGNVLTCLVI-ARHKAMRTPTNYYLFSLAVSDLLVLLLGMPLELYELWQNYPFLL----GSGGCYFKTF 79
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 530416909  98 AMTFFGLASMLILFAMAVERCLALSHPyLYAQLDGPRCARLALPAIYAFCVLFCALP---LLGLGQHQQYCPGS 168
Cdd:cd15133   80 LFETVCLASILNVTALSVERYIAVVHP-LAARTCSTRPRVTRVLGCVWGVSMLCALPntsLHGIKFLGSGVPAS 152
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
18-156 5.20e-04

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 41.43  E-value: 5.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  18 ATSTLMFVAGVVGNGLALgILSARRPARPSAFAVLVTGLAATDL-LGTSFLSPAVFVAyarnssLLGLARGGPALCDAFA 96
Cdd:cd15959    5 ALLSLAILVIVGGNLLVI-VAIAKTPRLQTMTNVFVTSLACADLvMGLLVVPPGATIL------LTGHWPLGTTVCELWT 77
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  97 FAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLL 156
Cdd:cd15959   78 SVDVLCVTASIETLCAIAVDRYLAITNPLRYEALVTKRRARTAVCLVWAISAAISFLPIM 137
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
21-155 7.34e-04

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 40.78  E-value: 7.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  21 TLMFVAGVVGNgLALGILSARRPARPSAFAVLVTGLAATDLLGTSF-LSPAVFVAYARNSSLLGLArggpaLCDAFAFAM 99
Cdd:cd15134    8 GIIFVTGVVGN-LCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILgLPFELYTIWQQYPWVFGEV-----FCKLRAFLS 81
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 530416909 100 TFFGLASMLILFAMAVERCLALSHP-YLYAQLDGPRCARL-ALPAIYAFCvlfCALPL 155
Cdd:cd15134   82 EMSSYASVLTITAFSVERYLAICHPlRSHTMSKLSRAIRIiIAIWIIAFV---CALPF 136
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
21-150 1.50e-03

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 39.75  E-value: 1.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  21 TLMFVAGVVGNGLALGILSarRPARP-SAFAVLVTGLAATDLLGTsfLSPAVFVAYARNssllGLARGGPALC--DAFAF 97
Cdd:cd15154    8 SLLFPVGLLLNAVALWVFV--RYLRLhSVVSIYMCNLALSDLLFT--LSLPLRIYYYAN----HYWPFGNFLCqfSGSIF 79
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 530416909  98 AMTFFGlaSMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLF 150
Cdd:cd15154   80 QMNMYG--SCLFLMCINVDRYLAIVHPLRFRHLRRPKVARLLCLAVWALILGG 130
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
21-202 1.80e-03

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 39.33  E-value: 1.80e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  21 TLMFVAGVVGNGLALGILSARRpARPSAFAVLVTGLAATDLLGtsflspAVFVAYARNSSLLGLARGGP-ALCDAFAFAM 99
Cdd:cd14964    6 SLLTCLGLLGNLLVLLSLVRLR-KRPRSTRLLLASLAACDLLA------SLVVLVLFFLLGLTEASSRPqALCYLIYLLW 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909 100 TFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQP 179
Cdd:cd14964   79 YGANLASIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLVGKGAIPRYNTLTGSCYLICTTIY 158
                        170       180
                 ....*....|....*....|...
gi 530416909 180 GGAAFSLAYAGLVALLVAAIFLC 202
Cdd:cd14964  159 LTWGFLLVSFLLPLVAFLVIFSR 181
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
25-157 1.91e-03

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 39.49  E-value: 1.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  25 VAGVVGNGLA-LGILSARRPARPSAFavLVTGLAATDLLGTSFLSPavfvaYARNSSLLGLARGGPALCDAFAFAMTFFG 103
Cdd:cd15326   12 LFAIVGNILViLSVVCNRHLRIPTNY--FIVNLAIADLLLSFTVLP-----FSATLEILGYWVFGRIFCDIWAAVDVLCC 84
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 530416909 104 LASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLG 157
Cdd:cd15326   85 TASILSLCAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVLSTVISIGPLLG 138
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
18-169 2.29e-03

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 39.14  E-value: 2.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  18 ATSTLMFVAGVVGNGLALGILSARRpARPSAFAVLVTGLAATDLLgtsflsPAVFvayarnSSLLGLA-------RGGPA 90
Cdd:cd15196    5 AVLATILVLALFGNSCVLLVLYRRR-RKLSRMHLFILHLSVADLL------VALF------NVLPQLIwdityrfYGGDL 71
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530416909  91 LCDAFAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAiYAFCVLFCaLPLLGLGQHQQYCPGSW 169
Cdd:cd15196   72 LCRLVKYLQVVGMYASSYVLVATAIDRYIAICHPLSSHRWTSRRVHLMVAIA-WVLSLLLS-IPQLFIFSYQEVGSGVY 148
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
15-157 2.81e-03

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 38.97  E-value: 2.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  15 VGPATSTLMFVAGVVGNGLALGILsARRPARPSAfaVLVTGLAATDLLGTSFLSPAVFVAyarNSSLLGLARGGPALCDA 94
Cdd:cd15220    1 VGLFCMVLLDLTALVGNTAVMVVI-AKTPHLRKF--AFVCHLCVVDLLAALLLMPLGILS---SSPFFLGVVFGEAECRV 74
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530416909  95 FAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLG 157
Cdd:cd15220   75 YIFLSVCLVSASILTISAISVERYYYIVHPMRYEVKMTIGLVAAVLVGVWVKALLLGLLPVLG 137
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
25-159 3.70e-03

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 38.46  E-value: 3.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  25 VAGVVGNGLALGILSARRPARpSAFAVLVTGLAATDLlGTSFLS--PAVFVayarnSSLLGLARGGPALCDAFAFAMTFF 102
Cdd:cd15337   12 ILGVIGNLLVIYLFSKTKSLR-TPSNMFIINLAISDF-GFSAVNgfPLKTI-----SSFNKKWIWGKVACELYGFAGGIF 84
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 530416909 103 GLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLG 159
Cdd:cd15337   85 GFMSITTLAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSIPPFFGWG 141
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
18-125 3.92e-03

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 38.36  E-value: 3.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  18 ATSTLMFVAGVVGNGLALGILSARRPARpSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLlglargGPALC--DAF 95
Cdd:cd15155    5 AVYSVVFILGLITNCASLFVFCFRMKMR-NETAIFMTNLAVSDLLFVFTLPFKIFYNFNRHWPF------GDSLCkiSGT 77
                         90       100       110
                 ....*....|....*....|....*....|
gi 530416909  96 AFAMTFFGlaSMLILFAMAVERCLALSHPY 125
Cdd:cd15155   78 AFLTNIYG--SMLFLTCISVDRFLAIVYPF 105
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
24-138 4.48e-03

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 38.21  E-value: 4.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  24 FVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLARggpalCDAFAFAMTFFG 103
Cdd:cd15935   11 YAAILLGNLLIVVTVHADPHLLQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGG-----CMAQLFFLHFLG 85
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 530416909 104 LASMLILFAMAVERCLALSHPYLY-AQLDGPRCARL 138
Cdd:cd15935   86 GSEMLLLTLMAYDRYVAICHPLRYlAVMNRQLCIKL 121
7tmA_SREB1_GPR27 cd15216
super conserved receptor expressed in brain 1 (or GPR27), member of the class A family of ...
18-201 4.98e-03

super conserved receptor expressed in brain 1 (or GPR27), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320344 [Multi-domain]  Cd Length: 332  Bit Score: 38.47  E-value: 4.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  18 ATSTLMFVAGVVGNGLaLGILSARRPARPSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGlARGGPALCDAFAF 97
Cdd:cd15216    5 ATLSLLLCVSLAGNVL-FALLIVRERSLHRAPYYLLLDLCLADGLRALACLPAVMLAARRAAAAAG-TPPGALGCKLLAF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  98 AMTFFGLASMLILFAMAVERCLALSHPYLYAQ-LDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQycPGSWCFLRMRw 176
Cdd:cd15216   83 LAALFCFHAAFLLLGVGVTRYLAIAHHRFYAErLAGWPCAAMLVCAAWALALAAAFPPVLDGGGADD--EDAPCALEQR- 159
                        170       180
                 ....*....|....*....|....*
gi 530416909 177 aqPGGAAFSLAYAGLVALLVAAIFL 201
Cdd:cd15216  160 --PDGAPGALGFLLLLAAVVGATHL 182
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
19-231 5.75e-03

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 38.15  E-value: 5.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  19 TSTLMFVAgVVGNGLALGILSARRPARpSAFAVLVTGLAATDLLGTSFLSP--AVFvayarNSSLLGLArgGPALCDAFA 96
Cdd:cd15195    7 TWVLFVIS-AAGNLTVLIQLFRRRRAK-SHIQILIMHLALADLMVTFFNMPmdAVW-----NYTVEWLA--GDLMCRVMM 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  97 FAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDgPRCARLALPAiyAFCVLFCALPLLGLGQHQQYCPG--------S 168
Cdd:cd15195   78 FLKQFGMYLSSFMLVVIALDRVFAILSPLSANQAR-KRVKIMLTVA--WVLSALCSIPQSFIFSVLRKMPEqpgfhqcvD 154
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530416909 169 WCFLRMRWAQPGGAAFSLAYAGLVALLVaaIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTG 231
Cdd:cd15195  155 FGSAPTKKQERLYYFFTMILSFVIPLII--TVTCYLLILFEISKMAKRARDTPISNRRRSRTN 215
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
21-154 6.76e-03

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 37.87  E-value: 6.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416909  21 TLMFVAGVVGNGLALGILSARRPARpSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLArggpaLCDAFAFAMT 100
Cdd:cd15202    8 SFIIVFSLFGNVLVCWIIFKNQRMR-TVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLF-----MCHFSNFAQY 81
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 530416909 101 FFGLASMLILFAMAVERCLALSHPYlyaqldGPRCARLALPAIYA---FCVLFCALP 154
Cdd:cd15202   82 CSVHVSAYTLTAIAVDRYQAIMHPL------KPRISKTKAKFIIAviwTLALAFALP 132
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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