N-terminal sub-domain of the Rel homology domain (RHD) of the reticuloendotheliosis viral oncogene homolog B (RelB) protein; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the RelB family of transcription factors, categorized as class II NF-kappa B family members. In class II NF-kappa Bs, the RHD domain co-occurs with a C-terminal transactivation domain (TAD). NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and Rel). RelB, is unable to homodimerize but is a potent transactivator in a heterodimer with NF-kappa B1 (p50) or B2 (p52). It is involved in the regulation of genes that play roles in inflammatory processes and the immune response.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416980 125 PHLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEVTACLVWKDWPHRVHPHSLVGKDCT 204
Cdd:cd07886    1 PRLLITEQPKQRGMRFRYECEGRSAGSILGESSTEANKTQPAIEIQNCIGLKEVTVTVCLVWKDPPHRVHPHGLVGKDCP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416980 205 DGICRVRLRPHVSPRHSFNNLGIQCVRKKEIEAAIERKIQLGIDPYNAGSLKNHQEVDMNVVRICFQASYRDQQGQMRRM 284
Cdd:cd07886   81 NGICQVTLNPHSSPRHSFSNLGIQCVRKREIEAAIETRLQLNIDPFKAGSLKNHEEVDMNVVRLCFQASYRDDDGRKDCL 160

                        170
                 ....*....|..
gi 530416980 285 DPVLSEPVYDKK 296
Cdd:cd07886  161 SPVLSEPIYDKK 172

RelB leucine zipper; This domain is a leucine zipper found in RelB transcription factors.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530416980   18 MPSRRVARPPAAPELGALGSPDLSSLSLAVSRSTdelEIIDEYIKENGFGLDGGQPGPGEGLPRLVSRGAASLSTVTLG 96
Cdd:pfam16180   1 MPSRRVARSSAAPELGPLGSADLSSLSLAVSRTT---EIIDEYIKENGFGLAGSQPGSGAGLPRLVSRGAASLSSVTLG 76

N-terminal sub-domain of the Rel homology domain (RHD) of the reticuloendotheliosis viral oncogene homolog B (RelB) protein; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the RelB family of transcription factors, categorized as class II NF-kappa B family members. In class II NF-kappa Bs, the RHD domain co-occurs with a C-terminal transactivation domain (TAD). NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and Rel). RelB, is unable to homodimerize but is a potent transactivator in a heterodimer with NF-kappa B1 (p50) or B2 (p52). It is involved in the regulation of genes that play roles in inflammatory processes and the immune response.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416980 125 PHLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEVTACLVWKDWPHRVHPHSLVGKDCT 204
Cdd:cd07886    1 PRLLITEQPKQRGMRFRYECEGRSAGSILGESSTEANKTQPAIEIQNCIGLKEVTVTVCLVWKDPPHRVHPHGLVGKDCP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416980 205 DGICRVRLRPHVSPRHSFNNLGIQCVRKKEIEAAIERKIQLGIDPYNAGSLKNHQEVDMNVVRICFQASYRDQQGQMRRM 284
Cdd:cd07886   81 NGICQVTLNPHSSPRHSFSNLGIQCVRKREIEAAIETRLQLNIDPFKAGSLKNHEEVDMNVVRLCFQASYRDDDGRKDCL 160

                        170
                 ....*....|..
gi 530416980 285 DPVLSEPVYDKK 296
Cdd:cd07886  161 SPVLSEPIYDKK 172

Rel homology DNA-binding domain; Proteins containing the Rel homology domain (RHD) are eukaryotic transcription factors. The RHD is composed of two structural domains. This is the N-terminal DNA-binding domain that is similar to that found in P53. The C-terminal domain has an immunoglobulin-like fold (See pfam16179) that functions as a dimerization domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416980  127 LVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGlrEVEVTACLVWKDWPHRVHPHSLVGKDCTDG 206
Cdd:pfam00554   1 LEIVEQPKQRGMRFRYKCEGRSAGSIPGESSTRSKKTFPTVQICNYDG--PAVIRVSLVTKDEPHRPHPHSLVGKDCKDG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416980  207 ICRVRLRPHvSPRHSFNNLGIQCVRKKEIEAAIERKIQLGIDPYN--AGSLKNHQEVDMNVVRICFQASYRDQQGQ-MRR 283
Cdd:pfam00554  79 VCEVELGPE-DMVASFQNLGIQCVKKKDVEEALKERIELNIDPFNvgFEALRQIKDMDLNVVRLCFQAFLPDTRGNfTTP 157

                         170
                  ....*....|..
gi 530416980  284 MDPVLSEPVYDK 295
Cdd:pfam00554 158 LPPVVSNPIYDK 169

IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to certain chemicals. NFkappaB blocking cell apoptosis in several cell types, gives it an important role in cell proliferation and differentiation.

                         10        20
                 ....*....|....*....|....*....
gi 530416980 303 LRICRINKESGPCTGGEELYLLCDKVQKD 331
Cdd:cd01177    1 LKICRLDKTSGSVKGGDEVYLLCDKVQKE 29

ig-like, plexins, transcription factors;

                           10        20        30
                   ....*....|....*....|....*....|....
gi 530416980   302 ELRICRINKESGPCTGGEELyLLCDKVQKDSYGV 335
Cdd:smart00429   1 DPVITRISPTSGPVSGGTEI-TLCGKNLKSISVV 33

N-terminal sub-domain of the Rel homology domain (RHD) of the reticuloendotheliosis viral oncogene homolog B (RelB) protein; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the RelB family of transcription factors, categorized as class II NF-kappa B family members. In class II NF-kappa Bs, the RHD domain co-occurs with a C-terminal transactivation domain (TAD). NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and Rel). RelB, is unable to homodimerize but is a potent transactivator in a heterodimer with NF-kappa B1 (p50) or B2 (p52). It is involved in the regulation of genes that play roles in inflammatory processes and the immune response.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416980 125 PHLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEVTACLVWKDWPHRVHPHSLVGKDCT 204
Cdd:cd07886    1 PRLLITEQPKQRGMRFRYECEGRSAGSILGESSTEANKTQPAIEIQNCIGLKEVTVTVCLVWKDPPHRVHPHGLVGKDCP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416980 205 DGICRVRLRPHVSPRHSFNNLGIQCVRKKEIEAAIERKIQLGIDPYNAGSLKNHQEVDMNVVRICFQASYRDQQGQMRRM 284
Cdd:cd07886   81 NGICQVTLNPHSSPRHSFSNLGIQCVRKREIEAAIETRLQLNIDPFKAGSLKNHEEVDMNVVRLCFQASYRDDDGRKDCL 160

                        170
                 ....*....|..
gi 530416980 285 DPVLSEPVYDKK 296
Cdd:cd07886  161 SPVLSEPIYDKK 172

N-terminal sub-domain of the Rel homology domain (RHD); Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal sub-domain, which may be distantly related to the DNA-binding domain found in P53. The C-terminal sub-domain has an immunoglobulin-like fold and serves as a dimerization module that also binds DNA (see cd00102). The RHD is found in NF-kappa B, nuclear factor of activated T-cells (NFAT), the tonicity-responsive enhancer binding protein (TonEBP), and the arthropod proteins Dorsal and Relish (Rel).

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416980 125 PHLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGlrEVEVTACLVWKDWPHRVHPHSLVGK-DC 203
Cdd:cd07827    1 PYLEITEQPKQRGHRFRYECEGRSAGSIPGENSTADRKTFPTVKLRNYNG--PAKIVVSLVTKDDPPKPHPHQLVGKtDC 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416980 204 TDGICRVRLRPHVSPRHSFNNLGIQCVRKKEIEAAIERKIQLGIDPY--NAGSLKNHQEVDMNVVRICFQASYRDQQGQM 281
Cdd:cd07827   79 RDGVCEVRLGPKNNMTASFNNLGIQCVRKKDVEEALGQRIQLGIDPFmvHKGPEGNASDIDLNRVRLCFQAFIEDSDGGF 158

                        170
                 ....*....|....*.
gi 530416980 282 R-RMDPVLSEPVYDKK 296
Cdd:cd07827  159 TlPLPPVLSNPIYDKK 174

N-terminal sub-domain of the Rel homology domain (RHD) of the arthropod protein Dorsal; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the arthropod Dorsal and Dif (Dorsal-related immunity factor), and similar proteins. Dorsal and Dif are Rel-like transcription factors, which play roles in mediating innate immunity in Drosophila. They are activated via the Toll pathway. Cytoplasmic Dorsal/Dif are inactivated via forming a complex with Cactus, the Drosophila homologue of mammalian I-kappa B proteins. In response to signals, Cactus is degraded and Dorsal/Dif can be transported into the nucleus, where they act as transcription factors. Dorsal is also an essential gene in establishing the proper dorsal/ventral polarity in the developing embryo.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416980 125 PHLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGlREVEVTAClVWKDWPHRVHPHSLVGK-DC 203
Cdd:cd07887    1 PYVRIVEQPTSRALRFRYECEGRSAGSIPGANSTSEGKTFPTIQVVNYDG-RAVVVVSC-VTKDEPFRPHPHNLVGKeGC 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416980 204 TDGICRVRLRPHvSPRHSFNNLGIQCVRKKEIEAAIERKIQLGIDPYNAG-SLKNH-QEVDMNVVRICFQASYRDQQGQM 281
Cdd:cd07887   79 KKGVCTKKINPT-EMRIVFQKLGIQCVKKKDVEESLKLREEINVDPFRTGfDHKDQiNSIDLNVVRLCFQVFLEDENGRF 157

                        170
                 ....*....|....*.
gi 530416980 282 RR-MDPVLSEPVYDKK 296
Cdd:cd07887  158 TVpLPPVVSDPIYDKK 173

N-terminal sub-domain of the Rel homology domain (RHD) of c-Rel; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the c-Rel family of transcription factors, categorized as a class II member of the NF-kappa B family. In class II NF-kappa Bs, the RHD domain co-occurs with a C-terminal transactivation domain (TAD). NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and Rel). c-Rel plays an important role in B cell proliferation and survival.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416980 125 PHLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEVTacLVWKDWPHRVHPHSLVGKDCT 204
Cdd:cd07933    1 PYVEIFEQPRQRGMRFRYKCEGRSAGSIPGERSTDNNRTYPSIQILNYTGKGKVRIT--LVTKNEPYKPHPHDLVGKDCR 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416980 205 DGICRVRLRPHVSPRhSFNNLGIQCVRKKEIEAAIERKIQLGIDPYNAG--SLKNHQEVDMNVVRICFQASYRDQQGQMR 282
Cdd:cd07933   79 DGYYEAEFGPERRVL-AFQNLGIQCVRRREVKEAIMLRISRGINPFNVPeeQLLQIEEYDLNVVRLCFQIFLPDEHGNYT 157

                        170
                 ....*....|....*
gi 530416980 283 RM-DPVLSEPVYDKK 296
Cdd:cd07933  158 TAlPPIVSNPIYDNR 172

RelB leucine zipper; This domain is a leucine zipper found in RelB transcription factors.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530416980   18 MPSRRVARPPAAPELGALGSPDLSSLSLAVSRSTdelEIIDEYIKENGFGLDGGQPGPGEGLPRLVSRGAASLSTVTLG 96
Cdd:pfam16180   1 MPSRRVARSSAAPELGPLGSADLSSLSLAVSRTT---EIIDEYIKENGFGLAGSQPGSGAGLPRLVSRGAASLSSVTLG 76

N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor kappa B2 (NF-kappa B2); Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the NF-kappa B2 family of transcription factors, a class I member of the NF-kappa B family. In class I NF-kappa Bs, the RHD domain co-occurs with C-terminal ankyrin repeats. NF-kappa B2 is commonly referred to as p100 or p52 (proteolytically processed form). NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and REL). NF-kappa B2 is involved in the alternative NF-kappa B signaling pathway which is activated by few agonists and plays an important role in secondary lymphoid organogenesis, maturation of B-cells, and adaptive humoral immunity. p100 may also act as an I-kappa B due to its C-terminal ankyrin repeats.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416980 125 PHLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEVTacLVWKDWPHRVHPHSLVGKDCT 204
Cdd:cd07934    1 PYLVIIEQPKQRGFRFRYVCEGPSHGGLPGASSEKGRKTYPTVKICNYVGMARIEVD--LVTHTDPPRVHAHSLVGKHCN 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530416980 205 D-GICRVRLRPHvSPRHSFNNLGIQCVRKKEIEAAIERKIQLGI----DPY---NAGSLKNHQEV-------DMNVVRIC 269
Cdd:cd07934   79 EsGNCSVDVGPK-DMTAQFSNLGILHVTKKNMMEILKEKLKRQKlrntGPYkltEAEERELEQEAkelkkvmDLSIVRLK 157

                        170       180
                 ....*....|....*....|....*...
gi 530416980 270 FQASYRDQQGQMRR-MDPVLSEPVYDKK 296
Cdd:cd07934  158 FTAYLRDSNGSYTLaLKPVISDPIHDSK 185

IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to certain chemicals. NFkappaB blocking cell apoptosis in several cell types, gives it an important role in cell proliferation and differentiation.

                         10        20
                 ....*....|....*....|....*....
gi 530416980 303 LRICRINKESGPCTGGEELYLLCDKVQKD 331
Cdd:cd01177    1 LKICRLDKTSGSVKGGDEVYLLCDKVQKE 29

IPT domain of eukaryotic transcription factors NF-kappaB/Rel, nuclear factor of activated Tcells (NFAT), and recombination signal J-kappa binding protein (RBP-Jkappa). The IPT domains in these proteins are involved in DNA binding. Most NF-kappaB/Rel proteins form homo- and heterodimers, while NFAT proteins are largely monomeric (with TonEBP being an exception). While the majority of sequence-specific DNA binding elements are found in the N-terminal domain, several are found in the IPT domain in loops adjacent to, and including, the linker region.

                         10        20
                 ....*....|....*....|....*....
gi 530416980 303 LRICRINKESGPCTGGEELYLLCDKVQKD 331
Cdd:cd00602    1 LPICRVSSLSGSVNGGDEVFLLCDKVNKP 29