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Conserved domains on  [gi|530414500|ref|XP_005259796|]
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leucine-rich repeat-containing protein 25 isoform X1 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1001123)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; similar to Oryctolagus cuniculus monocyte differentiation antigen CD14, a coreceptor for bacterial lipopolysaccharide

Gene Ontology:  GO:0005515
PubMed:  11751054

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
4-105 7.96e-04

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 40.69  E-value: 7.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530414500   4 TLAWTLLLPLLLRESDSLEPSCTVSSADVDWNAEFSATCLNFSGL-SLSLPHNQSL-RASNVILLDLSGNGLRELPVtFF 81
Cdd:COG4886   54 SLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLtELDLSGNEELsNLTNLESLDLSGNQLTDLPE-EL 132

                         90       100
                 ....*....|....*....|....
gi 530414500  82 AHLQKLEVLNVLRNPLSRVDGALA 105
Cdd:COG4886  133 ANLTNLKELDLSNNQLTDLPEPLG 156
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
4-105 7.96e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 40.69  E-value: 7.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530414500   4 TLAWTLLLPLLLRESDSLEPSCTVSSADVDWNAEFSATCLNFSGL-SLSLPHNQSL-RASNVILLDLSGNGLRELPVtFF 81
Cdd:COG4886   54 SLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLtELDLSGNEELsNLTNLESLDLSGNQLTDLPE-EL 132

                         90       100
                 ....*....|....*....|....
gi 530414500  82 AHLQKLEVLNVLRNPLSRVDGALA 105
Cdd:COG4886  133 ANLTNLKELDLSNNQLTDLPEPLG 156
LRR_8 pfam13855
Leucine rich repeat;
66-102 4.02e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.19  E-value: 4.02e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 530414500   66 LDLSGNGLRELPVTFFAHLQKLEVLNVLRNPLSRVDG 102
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSP 42
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 45-133 7.29e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.07  E-value: 7.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530414500  45 FSGLSLSlphnQSLRasnviLLDLSGNGLRELpvTFFAHLQKLEVLNVLRNPLSrvdgalaarcdlDLQADCNcALESWH 124
Cdd:cd21340  113 RSLAALS----NSLR-----VLNISGNNIDSL--EPLAPLRNLEQLDASNNQIS------------DLEELLD-LLSSWP 168


                 ....*....
gi 530414500 125 DIRRDNCSG 133
Cdd:cd21340  169 SLRELDLTG 177
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
4-105 7.96e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 40.69  E-value: 7.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530414500   4 TLAWTLLLPLLLRESDSLEPSCTVSSADVDWNAEFSATCLNFSGL-SLSLPHNQSL-RASNVILLDLSGNGLRELPVtFF 81
Cdd:COG4886   54 SLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLtELDLSGNEELsNLTNLESLDLSGNQLTDLPE-EL 132

                         90       100
                 ....*....|....*....|....
gi 530414500  82 AHLQKLEVLNVLRNPLSRVDGALA 105
Cdd:COG4886  133 ANLTNLKELDLSNNQLTDLPEPLG 156
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
41-105 1.05e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 40.30  E-value: 1.05e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530414500  41 TCLNFSGLSLS-LPHNQSlRASNVILLDLSGNGLRELPvTFFAHLQKLEVLNVLRNPLSRVDGALA 105
Cdd:COG4886  116 ESLDLSGNQLTdLPEELA-NLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEELG 179
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
44-113 3.83e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 38.76  E-value: 3.83e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530414500  44 NFSGLSLSLPHNQSLRasnviLLDLSGNGLRELPVtfFAHLQKLEVLNVLRNPLSRVD--GALAARCDLDLQ 113
Cdd:COG4886  216 QLTDLPEPLANLTNLE-----TLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPplANLTNLKTLDLS 280
LRR_8 pfam13855
Leucine rich repeat;
66-102 4.02e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.19  E-value: 4.02e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 530414500   66 LDLSGNGLRELPVTFFAHLQKLEVLNVLRNPLSRVDG 102
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSP 42
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 45-133 7.29e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.07  E-value: 7.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530414500  45 FSGLSLSlphnQSLRasnviLLDLSGNGLRELpvTFFAHLQKLEVLNVLRNPLSrvdgalaarcdlDLQADCNcALESWH 124
Cdd:cd21340  113 RSLAALS----NSLR-----VLNISGNNIDSL--EPLAPLRNLEQLDASNNQIS------------DLEELLD-LLSSWP 168


                 ....*....
gi 530414500 125 DIRRDNCSG 133
Cdd:cd21340  169 SLRELDLTG 177
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
44-105 7.37e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 37.61  E-value: 7.37e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530414500  44 NFSGL-SLSLPHNQ--SLRAS-----NVILLDLSGNGLRELPVTFfAHLQKLEVLNVLRNPLSRVDGALA 105
Cdd:COG4886  157 NLTNLkSLDLSNNQltDLPEElgnltNLKELDLSNNQITDLPEPL-GNLTNLEELDLSGNQLTDLPEPLA 225
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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