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Conserved domains on  [gi|530378361|ref|XP_005263375|]
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neurotrypsin isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SR smart00202
Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...
 280-380 5.42e-46

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.


:

Pssm-ID: 214555 [Multi-domain]  Cd Length: 101  Bit Score: 156.73  E-value: 5.42e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378361   280 IRLAGGSSVHEGRVELYHAGQWGTVCDDQWDDADAEVICRQLGLSGIAKAWHQAYFGEGSGPVMLDEVRCTGNELSIEQC 359
Cdd:smart00202   1 VRLVGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGSAYFGPGSGPIWLDNVRCSGTEASLSDC 80

                           90       100
                   ....*....|....*....|.
gi 530378361   360 PKSSWGEHNCGHKEDAGVSCT 380
Cdd:smart00202  81 PHSGWGSHNCSHGEDAGVVCS 101
SR smart00202
Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...
 387-486 5.92e-41

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.


:

Pssm-ID: 214555 [Multi-domain]  Cd Length: 101  Bit Score: 143.25  E-value: 5.92e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378361   387 IRLAGGKGSHEGRLEVYYRGQWGTVCDDGWTELNTYVVCRQLGFKYGKQASA-NHFEESTGPIWLDDVSCSGKETRFLQC 465
Cdd:smart00202   1 VRLVGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGsAYFGPGSGPIWLDNVRCSGTEASLSDC 80

                           90       100
                   ....*....|....*....|.
gi 530378361   466 SRRQWGRHDCSHREDVSIACY 486
Cdd:smart00202  81 PHSGWGSHNCSHGEDAGVVCS 101
SR smart00202
Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...
 170-270 2.29e-30

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.


:

Pssm-ID: 214555 [Multi-domain]  Cd Length: 101  Bit Score: 114.36  E-value: 2.29e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378361   170 VRLRGGKNEFEGTVEVYASGVWGTVCSSHWDDSDASVICHQLQLGGKGIAKQTPFSGLGLIPIYWSNVRCRGDEENILLC 249
Cdd:smart00202   1 VRLVGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGSAYFGPGSGPIWLDNVRCSGTEASLSDC 80

                           90       100
                   ....*....|....*....|.
gi 530378361   250 EKDIWQGGVCPQKMAAAVTCS 270
Cdd:smart00202  81 PHSGWGSHNCSHGEDAGVVCS 101
SR smart00202
Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...
 500-543 3.73e-19

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.


:

Pssm-ID: 214555 [Multi-domain]  Cd Length: 101  Bit Score: 82.77  E-value: 3.73e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 530378361   500 VRLMDGENKKEGRVEVFINGQWGTICDDGWTDKDAAVICRQLGY 543
Cdd:smart00202   1 VRLVGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGF 44
KR smart00130
Kringle domain; Named after a Danish pastry. Found in several serine proteases and in ROR-like ...
 99-164 3.07e-18

Kringle domain; Named after a Danish pastry. Found in several serine proteases and in ROR-like receptors. Can occur in up to 38 copies (in apolipoprotein(a)). Plasminogen-like kringles possess affinity for free lysine and lysine- containing peptides.


:

Pssm-ID: 214527  Cd Length: 83  Bit Score: 79.36  E-value: 3.07e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 530378361    99 WVSVTDFGAPCLRWAEVPPFLERSPPASWAQLrGQRHNFCRSPDG-AGRPWCFYGDARgkVDWGYCD 164
Cdd:smart00130  14 TVSVTKSGKPCQRWDSQTPHLHRFTPESFPDL-GLEENYCRNPDGdSEGPWCYTTDPN--VRWEYCD 77
 
Name Accession Description Interval E-value
SR smart00202
Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...
 280-380 5.42e-46

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.


Pssm-ID: 214555 [Multi-domain]  Cd Length: 101  Bit Score: 156.73  E-value: 5.42e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378361   280 IRLAGGSSVHEGRVELYHAGQWGTVCDDQWDDADAEVICRQLGLSGIAKAWHQAYFGEGSGPVMLDEVRCTGNELSIEQC 359
Cdd:smart00202   1 VRLVGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGSAYFGPGSGPIWLDNVRCSGTEASLSDC 80

                           90       100
                   ....*....|....*....|.
gi 530378361   360 PKSSWGEHNCGHKEDAGVSCT 380
Cdd:smart00202  81 PHSGWGSHNCSHGEDAGVVCS 101
SR smart00202
Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...
 387-486 5.92e-41

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.


Pssm-ID: 214555 [Multi-domain]  Cd Length: 101  Bit Score: 143.25  E-value: 5.92e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378361   387 IRLAGGKGSHEGRLEVYYRGQWGTVCDDGWTELNTYVVCRQLGFKYGKQASA-NHFEESTGPIWLDDVSCSGKETRFLQC 465
Cdd:smart00202   1 VRLVGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGsAYFGPGSGPIWLDNVRCSGTEASLSDC 80

                           90       100
                   ....*....|....*....|.
gi 530378361   466 SRRQWGRHDCSHREDVSIACY 486
Cdd:smart00202  81 PHSGWGSHNCSHGEDAGVVCS 101
SRCR pfam00530
Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular ...
 285-380 1.89e-38

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.


Pssm-ID: 459844  Cd Length: 98  Bit Score: 136.35  E-value: 1.89e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378361  285 GSSVHEGRVELYHAGQWGTVCDDQWDDADAEVICRQLGLSGIAKAW-HQAYFGEG-SGPVMLDEVRCTGNELSIEQCPKS 362
Cdd:pfam00530   1 GSSPCEGRVEVYHNGSWGTVCDDGWDLRDAHVVCRQLGCGGAVSAPsGCSYFGPGsTGPIWLDDVRCSGNETSLWQCPHR 80

                          90
                  ....*....|....*...
gi 530378361  363 SWGEHNCGHKEDAGVSCT 380
Cdd:pfam00530  81 PWGNHNCSHSEDAGVICS 98
SRCR pfam00530
Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular ...
 392-485 8.92e-35

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.


Pssm-ID: 459844  Cd Length: 98  Bit Score: 126.34  E-value: 8.92e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378361  392 GKGSHEGRLEVYYRGQWGTVCDDGWTELNTYVVCRQLGFKYGKQAS---ANHFEESTGPIWLDDVSCSGKETRFLQCSRR 468
Cdd:pfam00530   1 GSSPCEGRVEVYHNGSWGTVCDDGWDLRDAHVVCRQLGCGGAVSAPsgcSYFGPGSTGPIWLDDVRCSGNETSLWQCPHR 80

                          90
                  ....*....|....*..
gi 530378361  469 QWGRHDCSHREDVSIAC 485
Cdd:pfam00530  81 PWGNHNCSHSEDAGVIC 97
SR smart00202
Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...
 170-270 2.29e-30

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.


Pssm-ID: 214555 [Multi-domain]  Cd Length: 101  Bit Score: 114.36  E-value: 2.29e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378361   170 VRLRGGKNEFEGTVEVYASGVWGTVCSSHWDDSDASVICHQLQLGGKGIAKQTPFSGLGLIPIYWSNVRCRGDEENILLC 249
Cdd:smart00202   1 VRLVGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGSAYFGPGSGPIWLDNVRCSGTEASLSDC 80

                           90       100
                   ....*....|....*....|.
gi 530378361   250 EKDIWQGGVCPQKMAAAVTCS 270
Cdd:smart00202  81 PHSGWGSHNCSHGEDAGVVCS 101
SRCR pfam00530
Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular ...
 175-270 8.19e-26

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.


Pssm-ID: 459844  Cd Length: 98  Bit Score: 101.30  E-value: 8.19e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378361  175 GKNEFEGTVEVYASGVWGTVCSSHWDDSDASVICHQLQLGGKGIAKQTP--FSGLGLIPIYWSNVRCRGDEENILLCEKD 252
Cdd:pfam00530   1 GSSPCEGRVEVYHNGSWGTVCDDGWDLRDAHVVCRQLGCGGAVSAPSGCsyFGPGSTGPIWLDDVRCSGNETSLWQCPHR 80

                          90
                  ....*....|....*...
gi 530378361  253 IWQGGVCPQKMAAAVTCS 270
Cdd:pfam00530  81 PWGNHNCSHSEDAGVICS 98
SR smart00202
Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...
 500-543 3.73e-19

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.


Pssm-ID: 214555 [Multi-domain]  Cd Length: 101  Bit Score: 82.77  E-value: 3.73e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 530378361   500 VRLMDGENKKEGRVEVFINGQWGTICDDGWTDKDAAVICRQLGY 543
Cdd:smart00202   1 VRLVGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGF 44
KR smart00130
Kringle domain; Named after a Danish pastry. Found in several serine proteases and in ROR-like ...
 99-164 3.07e-18

Kringle domain; Named after a Danish pastry. Found in several serine proteases and in ROR-like receptors. Can occur in up to 38 copies (in apolipoprotein(a)). Plasminogen-like kringles possess affinity for free lysine and lysine- containing peptides.


Pssm-ID: 214527  Cd Length: 83  Bit Score: 79.36  E-value: 3.07e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 530378361    99 WVSVTDFGAPCLRWAEVPPFLERSPPASWAQLrGQRHNFCRSPDG-AGRPWCFYGDARgkVDWGYCD 164
Cdd:smart00130  14 TVSVTKSGKPCQRWDSQTPHLHRFTPESFPDL-GLEENYCRNPDGdSEGPWCYTTDPN--VRWEYCD 77
SRCR pfam00530
Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular ...
 510-543 3.09e-14

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.


Pssm-ID: 459844  Cd Length: 98  Bit Score: 68.56  E-value: 3.09e-14
                          10        20        30
                  ....*....|....*....|....*....|....
gi 530378361  510 EGRVEVFINGQWGTICDDGWTDKDAAVICRQLGY 543
Cdd:pfam00530   6 EGRVEVYHNGSWGTVCDDGWDLRDAHVVCRQLGC 39
KR cd00108
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as ...
 100-164 6.74e-11

Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and fibrinolytic proteins, some serine proteases and plasma proteins. Plasminogen-like kringles possess affinity for free lysine and lysine-containing peptides.


Pssm-ID: 238056  Cd Length: 83  Bit Score: 58.54  E-value: 6.74e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530378361 100 VSVTDFGAPCLRWAEVPPFLERSPPASWAQLRGqRHNFCRSPDGA-GRPWCFYGDarGKVDWGYCD 164
Cdd:cd00108   16 VSTTKSGKPCQRWNSQLPHQHKFNPERFPEGLL-EENYCRNPDGDpEGPWCYTTD--PNVRWEYCD 78
Kringle pfam00051
Kringle domain; Kringle domains have been found in plasminogen, hepatocyte growth factors, ...
 100-164 1.07e-09

Kringle domain; Kringle domains have been found in plasminogen, hepatocyte growth factors, prothrombin, and apolipoprotein A. Structure is disulfide-rich, nearly all-beta.


Pssm-ID: 395005  Cd Length: 79  Bit Score: 55.01  E-value: 1.07e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530378361  100 VSVTDFGAPCLRWAEVPPFLERSPPAS---WAQLRGqrhNFCRSPDGAGRPWCFYGDarGKVDWGYCD 164
Cdd:pfam00051  13 VSTTESGRPCQAWDSQTPHRHSKYTPEnfpAKGLGE---NYCRNPDGDERPWCYTTD--PRVRWEYCD 75
 
Name Accession Description Interval E-value
SR smart00202
Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...
 280-380 5.42e-46

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.


Pssm-ID: 214555 [Multi-domain]  Cd Length: 101  Bit Score: 156.73  E-value: 5.42e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378361   280 IRLAGGSSVHEGRVELYHAGQWGTVCDDQWDDADAEVICRQLGLSGIAKAWHQAYFGEGSGPVMLDEVRCTGNELSIEQC 359
Cdd:smart00202   1 VRLVGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGSAYFGPGSGPIWLDNVRCSGTEASLSDC 80

                           90       100
                   ....*....|....*....|.
gi 530378361   360 PKSSWGEHNCGHKEDAGVSCT 380
Cdd:smart00202  81 PHSGWGSHNCSHGEDAGVVCS 101
SR smart00202
Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...
 387-486 5.92e-41

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.


Pssm-ID: 214555 [Multi-domain]  Cd Length: 101  Bit Score: 143.25  E-value: 5.92e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378361   387 IRLAGGKGSHEGRLEVYYRGQWGTVCDDGWTELNTYVVCRQLGFKYGKQASA-NHFEESTGPIWLDDVSCSGKETRFLQC 465
Cdd:smart00202   1 VRLVGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGsAYFGPGSGPIWLDNVRCSGTEASLSDC 80

                           90       100
                   ....*....|....*....|.
gi 530378361   466 SRRQWGRHDCSHREDVSIACY 486
Cdd:smart00202  81 PHSGWGSHNCSHGEDAGVVCS 101
SRCR pfam00530
Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular ...
 285-380 1.89e-38

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.


Pssm-ID: 459844  Cd Length: 98  Bit Score: 136.35  E-value: 1.89e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378361  285 GSSVHEGRVELYHAGQWGTVCDDQWDDADAEVICRQLGLSGIAKAW-HQAYFGEG-SGPVMLDEVRCTGNELSIEQCPKS 362
Cdd:pfam00530   1 GSSPCEGRVEVYHNGSWGTVCDDGWDLRDAHVVCRQLGCGGAVSAPsGCSYFGPGsTGPIWLDDVRCSGNETSLWQCPHR 80

                          90
                  ....*....|....*...
gi 530378361  363 SWGEHNCGHKEDAGVSCT 380
Cdd:pfam00530  81 PWGNHNCSHSEDAGVICS 98
SRCR pfam00530
Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular ...
 392-485 8.92e-35

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.


Pssm-ID: 459844  Cd Length: 98  Bit Score: 126.34  E-value: 8.92e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378361  392 GKGSHEGRLEVYYRGQWGTVCDDGWTELNTYVVCRQLGFKYGKQAS---ANHFEESTGPIWLDDVSCSGKETRFLQCSRR 468
Cdd:pfam00530   1 GSSPCEGRVEVYHNGSWGTVCDDGWDLRDAHVVCRQLGCGGAVSAPsgcSYFGPGSTGPIWLDDVRCSGNETSLWQCPHR 80

                          90
                  ....*....|....*..
gi 530378361  469 QWGRHDCSHREDVSIAC 485
Cdd:pfam00530  81 PWGNHNCSHSEDAGVIC 97
SR smart00202
Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...
 170-270 2.29e-30

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.


Pssm-ID: 214555 [Multi-domain]  Cd Length: 101  Bit Score: 114.36  E-value: 2.29e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378361   170 VRLRGGKNEFEGTVEVYASGVWGTVCSSHWDDSDASVICHQLQLGGKGIAKQTPFSGLGLIPIYWSNVRCRGDEENILLC 249
Cdd:smart00202   1 VRLVGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGSAYFGPGSGPIWLDNVRCSGTEASLSDC 80

                           90       100
                   ....*....|....*....|.
gi 530378361   250 EKDIWQGGVCPQKMAAAVTCS 270
Cdd:smart00202  81 PHSGWGSHNCSHGEDAGVVCS 101
SRCR pfam00530
Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular ...
 175-270 8.19e-26

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.


Pssm-ID: 459844  Cd Length: 98  Bit Score: 101.30  E-value: 8.19e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530378361  175 GKNEFEGTVEVYASGVWGTVCSSHWDDSDASVICHQLQLGGKGIAKQTP--FSGLGLIPIYWSNVRCRGDEENILLCEKD 252
Cdd:pfam00530   1 GSSPCEGRVEVYHNGSWGTVCDDGWDLRDAHVVCRQLGCGGAVSAPSGCsyFGPGSTGPIWLDDVRCSGNETSLWQCPHR 80

                          90
                  ....*....|....*...
gi 530378361  253 IWQGGVCPQKMAAAVTCS 270
Cdd:pfam00530  81 PWGNHNCSHSEDAGVICS 98
SR smart00202
Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...
 500-543 3.73e-19

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.


Pssm-ID: 214555 [Multi-domain]  Cd Length: 101  Bit Score: 82.77  E-value: 3.73e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 530378361   500 VRLMDGENKKEGRVEVFINGQWGTICDDGWTDKDAAVICRQLGY 543
Cdd:smart00202   1 VRLVGGGSPCEGRVEVYHNGQWGTVCDDGWDLRDANVVCRQLGF 44
KR smart00130
Kringle domain; Named after a Danish pastry. Found in several serine proteases and in ROR-like ...
 99-164 3.07e-18

Kringle domain; Named after a Danish pastry. Found in several serine proteases and in ROR-like receptors. Can occur in up to 38 copies (in apolipoprotein(a)). Plasminogen-like kringles possess affinity for free lysine and lysine- containing peptides.


Pssm-ID: 214527  Cd Length: 83  Bit Score: 79.36  E-value: 3.07e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 530378361    99 WVSVTDFGAPCLRWAEVPPFLERSPPASWAQLrGQRHNFCRSPDG-AGRPWCFYGDARgkVDWGYCD 164
Cdd:smart00130  14 TVSVTKSGKPCQRWDSQTPHLHRFTPESFPDL-GLEENYCRNPDGdSEGPWCYTTDPN--VRWEYCD 77
SRCR pfam00530
Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular ...
 510-543 3.09e-14

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.


Pssm-ID: 459844  Cd Length: 98  Bit Score: 68.56  E-value: 3.09e-14
                          10        20        30
                  ....*....|....*....|....*....|....
gi 530378361  510 EGRVEVFINGQWGTICDDGWTDKDAAVICRQLGY 543
Cdd:pfam00530   6 EGRVEVYHNGSWGTVCDDGWDLRDAHVVCRQLGC 39
KR cd00108
Kringle domain; Kringle domains are believed to play a role in binding mediators, such as ...
 100-164 6.74e-11

Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and fibrinolytic proteins, some serine proteases and plasma proteins. Plasminogen-like kringles possess affinity for free lysine and lysine-containing peptides.


Pssm-ID: 238056  Cd Length: 83  Bit Score: 58.54  E-value: 6.74e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530378361 100 VSVTDFGAPCLRWAEVPPFLERSPPASWAQLRGqRHNFCRSPDGA-GRPWCFYGDarGKVDWGYCD 164
Cdd:cd00108   16 VSTTKSGKPCQRWNSQLPHQHKFNPERFPEGLL-EENYCRNPDGDpEGPWCYTTD--PNVRWEYCD 78
Kringle pfam00051
Kringle domain; Kringle domains have been found in plasminogen, hepatocyte growth factors, ...
 100-164 1.07e-09

Kringle domain; Kringle domains have been found in plasminogen, hepatocyte growth factors, prothrombin, and apolipoprotein A. Structure is disulfide-rich, nearly all-beta.


Pssm-ID: 395005  Cd Length: 79  Bit Score: 55.01  E-value: 1.07e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 530378361  100 VSVTDFGAPCLRWAEVPPFLERSPPAS---WAQLRGqrhNFCRSPDGAGRPWCFYGDarGKVDWGYCD 164
Cdd:pfam00051  13 VSTTESGRPCQAWDSQTPHRHSKYTPEnfpAKGLGE---NYCRNPDGDERPWCYTTD--PRVRWEYCD 75
SRCR_2 pfam15494
Scavenger receptor cysteine-rich domain; SRCR_2 is a scavenger receptor cysteine-rich domain ...
 514-544 2.90e-03

Scavenger receptor cysteine-rich domain; SRCR_2 is a scavenger receptor cysteine-rich domain family found largely on vertebrate sequences up-stream of the trypsin-like transmembrane serine protease, Spinesin.


Pssm-ID: 464747  Cd Length: 99  Bit Score: 37.31  E-value: 2.90e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 530378361  514 EVFI--NGQWGTICDDGWTDKDAAVICRQLGYN 544
Cdd:pfam15494   7 QVYSsaRPSWLPVCSDDWNPAYGRAACQQLGYL 39
SRCR_2 pfam15494
Scavenger receptor cysteine-rich domain; SRCR_2 is a scavenger receptor cysteine-rich domain ...
 400-432 3.30e-03

Scavenger receptor cysteine-rich domain; SRCR_2 is a scavenger receptor cysteine-rich domain family found largely on vertebrate sequences up-stream of the trypsin-like transmembrane serine protease, Spinesin.


Pssm-ID: 464747  Cd Length: 99  Bit Score: 37.31  E-value: 3.30e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 530378361  400 LEVY--YRGQWGTVCDDGWTELNTYVVCRQLGFKY 432
Cdd:pfam15494   6 LQVYssARPSWLPVCSDDWNPAYGRAACQQLGYLR 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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