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Conserved domains on  [gi|530372904|ref|XP_005265403|]
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WD repeat-containing protein 48 isoform X1 [Homo sapiens]

Protein Classification

WD repeat WDR48 family protein( domain architecture ID 10078073)

WD repeat WDR48 family protein similar to WD repeat-containing protein 48, a regulator of deubiquitinating complexes, which acts as a strong activator of USP1, USP12 and USP46

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 30-286 4.55e-61

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 206.42  E-value: 4.55e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372904  30 RNGVNALQLDPALNRLFTAGRDSIIRIWSVNQhkqDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFC 109
Cdd:cd00200    9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLET---GELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372904 110 MSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTasnntvttsSLSGNKDSIYSLAMNQLGTIIVSGSTE 189
Cdd:cd00200   86 VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLT---------TLRGHTDWVNSVAFSPDGTFVASSSQD 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372904 190 KVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYS 269
Cdd:cd00200  157 GTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLAS 236

                        250
                 ....*....|....*..
gi 530372904 270 GGRDRKIYCTDLRNPDI 286
Cdd:cd00200  237 GSEDGTIRVWDLRTGEC 253
DUF3337 pfam11816
Domain of unknown function (DUF3337); This family of proteins are functionally uncharacterized. ...
 509-647 2.24e-37

Domain of unknown function (DUF3337); This family of proteins are functionally uncharacterized. This family is only found in eukaryotes. This presumed domain is typically between 285 to 342 amino acids in length.


:

Pssm-ID: 463358  Cd Length: 171  Bit Score: 137.43  E-value: 2.24e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372904  509 VPPHTPVIFGE-----AGGRTLFRLLCRDSGGETEsmLLNETVPQWVIDITVDKNMP--KFNKIPFYLQPHASSGAKTL- 580
Cdd:pfam11816   1 LPPDTTIIISEespdsGGGRDLYRGTVGDIGEDVD--LLEEVAPMWLGDVLLYNKIPpkEPVKISFVLQPWPGSDLPPDk 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530372904  581 ------KKDRLSASDMLQVRKVMEHVYEKIINLDNESQTTSSSNNEKPGEQEKeediavlAEEKIELLCQDQV 647
Cdd:pfam11816  79 lpelpnKNSRLNANRMLRVRKILAYVAEKLESLTPEMKPPSPDEDENADKKLK-------PEEYLELLCNDQV 144
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 30-286 4.55e-61

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 206.42  E-value: 4.55e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372904  30 RNGVNALQLDPALNRLFTAGRDSIIRIWSVNQhkqDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFC 109
Cdd:cd00200    9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLET---GELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372904 110 MSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTasnntvttsSLSGNKDSIYSLAMNQLGTIIVSGSTE 189
Cdd:cd00200   86 VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLT---------TLRGHTDWVNSVAFSPDGTFVASSSQD 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372904 190 KVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYS 269
Cdd:cd00200  157 GTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLAS 236

                        250
                 ....*....|....*..
gi 530372904 270 GGRDRKIYCTDLRNPDI 286
Cdd:cd00200  237 GSEDGTIRVWDLRTGEC 253
WD40 COG2319
WD40 repeat [General function prediction only];
30-276 1.63e-54

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 192.43  E-value: 1.63e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372904  30 RNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQdpyIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFC 109
Cdd:COG2319  162 SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKL---LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKL 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372904 110 MSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTasnntvttsSLSGNKDSIYSLAMNQLGTIIVSGSTE 189
Cdd:COG2319  239 LRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLR---------TLTGHSGGVNSVAFSPDGKLLASGSDD 309

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372904 190 KVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALqvndAFT---- 265
Cdd:COG2319  310 GTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSV----AFSpdgr 385

                        250
                 ....*....|.
gi 530372904 266 HVYSGGRDRKI 276
Cdd:COG2319  386 TLASGSADGTV 396
DUF3337 pfam11816
Domain of unknown function (DUF3337); This family of proteins are functionally uncharacterized. ...
 509-647 2.24e-37

Domain of unknown function (DUF3337); This family of proteins are functionally uncharacterized. This family is only found in eukaryotes. This presumed domain is typically between 285 to 342 amino acids in length.


Pssm-ID: 463358  Cd Length: 171  Bit Score: 137.43  E-value: 2.24e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372904  509 VPPHTPVIFGE-----AGGRTLFRLLCRDSGGETEsmLLNETVPQWVIDITVDKNMP--KFNKIPFYLQPHASSGAKTL- 580
Cdd:pfam11816   1 LPPDTTIIISEespdsGGGRDLYRGTVGDIGEDVD--LLEEVAPMWLGDVLLYNKIPpkEPVKISFVLQPWPGSDLPPDk 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530372904  581 ------KKDRLSASDMLQVRKVMEHVYEKIINLDNESQTTSSSNNEKPGEQEKeediavlAEEKIELLCQDQV 647
Cdd:pfam11816  79 lpelpnKNSRLNANRMLRVRKILAYVAEKLESLTPEMKPPSPDEDENADKKLK-------PEEYLELLCNDQV 144
Ubl_WDR48 cd17041
Ubiquitin-like (Ubl) domain found in WD repeat-containing protein 48 (WDR48) and similar ...
 561-647 1.01e-25

Ubiquitin-like (Ubl) domain found in WD repeat-containing protein 48 (WDR48) and similar proteins; WDR48, also termed USP1-associated factor 1 (UAF1), or WD repeat endosomal protein, or p80, is required for the histone deubiquitination activity. It stimulates activity of ubiquitin-specific proteases USP1, USP12, and USP46.As potential tumor suppressor, WDR48 in complex with deubiquitinase USP12 suppresses Akt-dependent cell survival signaling by stabilizing PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1). WDR48 also functions as a novel interaction partner of E1 helicase from anogenital human papillomavirus (HPV) types, and plays an essential role in anogenital HPV DNA replication. WDR48 contains a WD40 domain and a ubiquitin-like domain that shows high sequence and structural similarity with RING finger- and WD40-associated ubiquitin-like (RAWUL) domain.


Pssm-ID: 340561  Cd Length: 97  Bit Score: 101.59  E-value: 1.01e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372904 561 KFNKIPFYLQPHASSGA--KTLKKDRLSASDMLQVRKVMEHVYEKIINLDNESQTtsssnnekpgeqekeediAVLAEEK 638
Cdd:cd17041    1 EFPKISFFLQPHPSSGLppKTLKNDKLSASRMLRVRKVMEYVAEKLLGQEPESQD------------------ASNPEEK 62


                 ....*....
gi 530372904 639 IELLCQDQV 647
Cdd:cd17041   63 LELLCNDQV 71
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 113-286 1.90e-10

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 64.34  E-value: 1.90e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372904 113 LRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTAlTASNNTVTTSSLSGnKDSIYSLAMNQ-LGTIIVSGSTEKV 191
Cdd:PLN00181 479 LLNSSNLVCAIGFDRDGEFFATAGVNKKIKIFECESIIK-DGRDIHYPVVELAS-RSKLSGICWNSyIKSQVASSNFEGV 556

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372904 192 LRVWDPRTCAKLMKLKGHTDNVKAL-LLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVhDEGVWALQV-NDAFTHVYS 269
Cdd:PLN00181 557 VQVWDVARSQLVTEMKEHEKRVWSIdYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFpSESGRSLAF 635

                        170
                 ....*....|....*..
gi 530372904 270 GGRDRKIYCTDLRNPDI 286
Cdd:PLN00181 636 GSADHKVYYYDLRNPKL 652
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 199-238 4.57e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 4.57e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 530372904   199 TCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWS 238
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
203-238 1.39e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.41  E-value: 1.39e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 530372904  203 LMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWS 238
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 30-286 4.55e-61

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 206.42  E-value: 4.55e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372904  30 RNGVNALQLDPALNRLFTAGRDSIIRIWSVNQhkqDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFC 109
Cdd:cd00200    9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLET---GELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372904 110 MSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTasnntvttsSLSGNKDSIYSLAMNQLGTIIVSGSTE 189
Cdd:cd00200   86 VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLT---------TLRGHTDWVNSVAFSPDGTFVASSSQD 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372904 190 KVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYS 269
Cdd:cd00200  157 GTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLAS 236

                        250
                 ....*....|....*..
gi 530372904 270 GGRDRKIYCTDLRNPDI 286
Cdd:cd00200  237 GSEDGTIRVWDLRTGEC 253
WD40 COG2319
WD40 repeat [General function prediction only];
30-276 1.63e-54

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 192.43  E-value: 1.63e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372904  30 RNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQdpyIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFC 109
Cdd:COG2319  162 SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKL---LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKL 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372904 110 MSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTasnntvttsSLSGNKDSIYSLAMNQLGTIIVSGSTE 189
Cdd:COG2319  239 LRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLR---------TLTGHSGGVNSVAFSPDGKLLASGSDD 309

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372904 190 KVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALqvndAFT---- 265
Cdd:COG2319  310 GTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSV----AFSpdgr 385

                        250
                 ....*....|.
gi 530372904 266 HVYSGGRDRKI 276
Cdd:COG2319  386 TLASGSADGTV 396
WD40 COG2319
WD40 repeat [General function prediction only];
30-283 9.39e-54

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 190.12  E-value: 9.39e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372904  30 RNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQdpyIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFC 109
Cdd:COG2319  120 TGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKL---LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKL 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372904 110 MSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTasnntvttsSLSGNKDSIYSLAMNQLGTIIVSGSTE 189
Cdd:COG2319  197 LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLR---------TLTGHSGSVRSVAFSPDGRLLASGSAD 267

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372904 190 KVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYS 269
Cdd:COG2319  268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLAS 347

                        250
                 ....*....|....
gi 530372904 270 GGRDRKIYCTDLRN 283
Cdd:COG2319  348 GSDDGTVRLWDLAT 361
WD40 COG2319
WD40 repeat [General function prediction only];
30-276 1.31e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 189.74  E-value: 1.31e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372904  30 RNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQdpyIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFC 109
Cdd:COG2319   78 TAAVLSVAFSPDGRLLASASADGTVRLWDLATGLL---LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKL 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372904 110 MSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTasnntvttsSLSGNKDSIYSLAMNQLGTIIVSGSTE 189
Cdd:COG2319  155 LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR---------TLTGHTGAVRSVAFSPDGKLLASGSAD 225

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372904 190 KVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALqvndAFT---- 265
Cdd:COG2319  226 GTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSV----AFSpdgk 301

                        250
                 ....*....|.
gi 530372904 266 HVYSGGRDRKI 276
Cdd:COG2319  302 LLASGSDDGTV 312
WD40 COG2319
WD40 repeat [General function prediction only];
31-239 1.44e-47

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 173.17  E-value: 1.44e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372904  31 NGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQdpyIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCM 110
Cdd:COG2319  205 GAVRSVAFSPDGKLLASGSADGTVRLWDLATGKL---LRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELL 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372904 111 STLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTasnntvttsSLSGNKDSIYSLAMNQLGTIIVSGSTEK 190
Cdd:COG2319  282 RTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR---------TLTGHTGAVRSVAFSPDGKTLASGSDDG 352

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 530372904 191 VLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSL 239
Cdd:COG2319  353 TVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 31-238 9.75e-43

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 156.34  E-value: 9.75e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372904  31 NGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQdpyIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCM 110
Cdd:cd00200   94 SYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKC---LTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCV 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372904 111 STLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTasnntvttsSLSGNKDSIYSLAMNQLGTIIVSGSTEK 190
Cdd:cd00200  171 ATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLG---------TLRGHENGVNSVAFSPDGYLLASGSEDG 241

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 530372904 191 VLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWS 238
Cdd:cd00200  242 TIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
DUF3337 pfam11816
Domain of unknown function (DUF3337); This family of proteins are functionally uncharacterized. ...
 509-647 2.24e-37

Domain of unknown function (DUF3337); This family of proteins are functionally uncharacterized. This family is only found in eukaryotes. This presumed domain is typically between 285 to 342 amino acids in length.


Pssm-ID: 463358  Cd Length: 171  Bit Score: 137.43  E-value: 2.24e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372904  509 VPPHTPVIFGE-----AGGRTLFRLLCRDSGGETEsmLLNETVPQWVIDITVDKNMP--KFNKIPFYLQPHASSGAKTL- 580
Cdd:pfam11816   1 LPPDTTIIISEespdsGGGRDLYRGTVGDIGEDVD--LLEEVAPMWLGDVLLYNKIPpkEPVKISFVLQPWPGSDLPPDk 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 530372904  581 ------KKDRLSASDMLQVRKVMEHVYEKIINLDNESQTTSSSNNEKPGEQEKeediavlAEEKIELLCQDQV 647
Cdd:pfam11816  79 lpelpnKNSRLNANRMLRVRKILAYVAEKLESLTPEMKPPSPDEDENADKKLK-------PEEYLELLCNDQV 144
WD40 COG2319
WD40 repeat [General function prediction only];
37-276 5.93e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 128.49  E-value: 5.93e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372904  37 QLDPALNRLFTAGRDSIIRIWSVNQHKQdpyIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTH 116
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGAL---LLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGH 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372904 117 KDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTAsnntvttssLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWD 196
Cdd:COG2319   78 TAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRT---------LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372904 197 PRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALqvndAF----THVYSGGR 272
Cdd:COG2319  149 LATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV----AFspdgKLLASGSA 224


                 ....
gi 530372904 273 DRKI 276
Cdd:COG2319  225 DGTV 228
WD40 COG2319
WD40 repeat [General function prediction only];
31-199 1.34e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 127.72  E-value: 1.34e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372904  31 NGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQdpyIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCM 110
Cdd:COG2319  247 GSVRSVAFSPDGRLLASGSADGTVRLWDLATGEL---LRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLL 323

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372904 111 STLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTasnntvttsSLSGNKDSIYSLAMNQLGTIIVSGSTEK 190
Cdd:COG2319  324 RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLR---------TLTGHTGAVTSVAFSPDGRTLASGSADG 394


                 ....*....
gi 530372904 191 VLRVWDPRT 199
Cdd:COG2319  395 TVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 109-282 4.65e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 117.44  E-value: 4.65e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372904 109 CMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALT------------------------ASNNTV----- 159
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRtlkghtgpvrdvaasadgtylasgSSDKTIrlwdl 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372904 160 ----TTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIR 235
Cdd:cd00200   81 etgeCVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 530372904 236 LWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLR 282
Cdd:cd00200  161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS 207
Ubl_WDR48 cd17041
Ubiquitin-like (Ubl) domain found in WD repeat-containing protein 48 (WDR48) and similar ...
 561-647 1.01e-25

Ubiquitin-like (Ubl) domain found in WD repeat-containing protein 48 (WDR48) and similar proteins; WDR48, also termed USP1-associated factor 1 (UAF1), or WD repeat endosomal protein, or p80, is required for the histone deubiquitination activity. It stimulates activity of ubiquitin-specific proteases USP1, USP12, and USP46.As potential tumor suppressor, WDR48 in complex with deubiquitinase USP12 suppresses Akt-dependent cell survival signaling by stabilizing PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1). WDR48 also functions as a novel interaction partner of E1 helicase from anogenital human papillomavirus (HPV) types, and plays an essential role in anogenital HPV DNA replication. WDR48 contains a WD40 domain and a ubiquitin-like domain that shows high sequence and structural similarity with RING finger- and WD40-associated ubiquitin-like (RAWUL) domain.


Pssm-ID: 340561  Cd Length: 97  Bit Score: 101.59  E-value: 1.01e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372904 561 KFNKIPFYLQPHASSGA--KTLKKDRLSASDMLQVRKVMEHVYEKIINLDNESQTtsssnnekpgeqekeediAVLAEEK 638
Cdd:cd17041    1 EFPKISFFLQPHPSSGLppKTLKNDKLSASRMLRVRKVMEYVAEKLLGQEPESQD------------------ASNPEEK 62


                 ....*....
gi 530372904 639 IELLCQDQV 647
Cdd:cd17041   63 LELLCNDQV 71
WD40 COG2319
WD40 repeat [General function prediction only];
29-104 3.55e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.70  E-value: 3.55e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 530372904  29 NRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQdpyIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNA 104
Cdd:COG2319  329 HTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL---LRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 113-286 1.90e-10

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 64.34  E-value: 1.90e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372904 113 LRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTAlTASNNTVTTSSLSGnKDSIYSLAMNQ-LGTIIVSGSTEKV 191
Cdd:PLN00181 479 LLNSSNLVCAIGFDRDGEFFATAGVNKKIKIFECESIIK-DGRDIHYPVVELAS-RSKLSGICWNSyIKSQVASSNFEGV 556

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372904 192 LRVWDPRTCAKLMKLKGHTDNVKAL-LLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVhDEGVWALQV-NDAFTHVYS 269
Cdd:PLN00181 557 VQVWDVARSQLVTEMKEHEKRVWSIdYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFpSESGRSLAF 635

                        170
                 ....*....|....*..
gi 530372904 270 GGRDRKIYCTDLRNPDI 286
Cdd:PLN00181 636 GSADHKVYYYDLRNPKL 652
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 206-295 6.33e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.81  E-value: 6.33e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372904 206 LKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPD 285
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84

                         90
                 ....*....|.
gi 530372904 286 -IRVLICEEKA 295
Cdd:cd00200   85 cVRTLTGHTSY 95
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 199-238 4.57e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 4.57e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 530372904   199 TCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWS 238
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
203-238 1.39e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.41  E-value: 1.39e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 530372904  203 LMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWS 238
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 44-202 1.54e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 51.43  E-value: 1.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372904  44 RLFTAGRDSIIRIWSV-----NQHKQDPyIASMEHHTDWVNDIVLCCNGK-TLISASSDTTVKVWNAHKGFCMSTLRTHK 117
Cdd:PTZ00421  90 KLFTASEDGTIMGWGIpeeglTQNISDP-IVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKAVEVIKCHS 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372904 118 DYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSlsgnKDSIYSLAMNQLGTIIVSGSTEKVLRVWDP 197
Cdd:PTZ00421 169 DQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKS----QRCLWAKRKDLIITLGCSKSQQRQIMLWDT 244


                 ....*
gi 530372904 198 RTCAK 202
Cdd:PTZ00421 245 RKMAS 249
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 68-103 1.95e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 1.95e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 530372904    68 IASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWN 103
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 10-269 4.71e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.09  E-value: 4.71e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372904  10 AGRRKVQV----SYvIRDEVEKYNRNGVnaLQL-DPALNRLFTAGRDSIIRIWSVNQHKQDPYIasmehhtdwvndivlc 84
Cdd:PLN00181 530 ASRSKLSGicwnSY-IKSQVASSNFEGV--VQVwDVARSQLVTEMKEHEKRVWSIDYSSADPTL---------------- 590

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372904  85 cngktLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNtltaltasNNTVTTSSL 164
Cdd:PLN00181 591 -----LASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPSESGRSLAFGSADHKVYYYDLR--------NPKLPLCTM 657

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372904 165 SGNKDSIYSLAMNQLGTiIVSGSTEKVLRVWDPRTCAK------LMKLKGHTdNVKALL-LNRDGTQCLSGSSDGTIRLW 237
Cdd:PLN00181 658 IGHSKTVSYVRFVDSST-LVSSSTDNTLKLWDLSMSISginetpLHSFMGHT-NVKNFVgLSVSDGYIATGSETNEVFVY 735

                        250       260       270
                 ....*....|....*....|....*....|...
gi 530372904 238 SLGQQRCIATYRVHD-EGVWALQVNDAFTHVYS 269
Cdd:PLN00181 736 HKAFPMPVLSYKFKTiDPVSGLEVDDASQFISS 768
WD40 pfam00400
WD domain, G-beta repeat;
68-103 6.61e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 6.61e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 530372904   68 IASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWN 103
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 106-145 1.43e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 1.43e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 530372904   106 KGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWD 145
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
107-145 4.23e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 4.23e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 530372904  107 GFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWD 145
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 41-151 9.65e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 45.65  E-value: 9.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530372904  41 ALNRLFTAGRDSIIRIWSVNQHKQDPYIASmehHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKD-Y 119
Cdd:PTZ00421 137 AMNVLASAGADMVVNVWDVERGKAVEVIKC---HSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASaK 213

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 530372904 120 VKALAYAKDKELVASAGLD----RQIFLWDVNTLTA 151
Cdd:PTZ00421 214 SQRCLWAKRKDLIITLGCSksqqRQIMLWDTRKMAS 249
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 162-196 6.05e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 6.05e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 530372904   162 SSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWD 196
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
161-196 1.42e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 1.42e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 530372904  161 TSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWD 196
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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