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Conserved domains on  [gi|530375762|ref|XP_005269337|]
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carboxypeptidase N subunit 2 isoform X1 [Homo sapiens]

Protein Classification

LRRNT and LRR domain-containing protein( domain architecture ID 12183445)

protein containing domains LRRNT, LRR, and LRRCT

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
95-419 9.24e-32

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 126.97  E-value: 9.24e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762  95 GLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNmlealpeGLFQHLAALESLHLQGNQLQALPRRLFQpLTHLKTL 174
Cdd:COG4886   70 SLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELAN-LTNLKEL 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762 175 NLAQNLLAQLPEELFHpLTSLQTLKLSNNALSGLPQgVFGKLGSLQELFLDSNNISELPPqVFSQLFCLERLWLQRNAIT 254
Cdd:COG4886  142 DLSNNQLTDLPEPLGN-LTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLT 218

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762 255 HLPLSIfASLGNLTFLSLQWNMLRVLPAglFAHTPCLVGLSLTHNQLETVAEgtFAHLSNLRSLMLSYNAITHLpagifr 334
Cdd:COG4886  219 DLPEPL-ANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDL------ 287

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762 335 DLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYT 414
Cdd:COG4886  288 KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLL 367


                 ....*
gi 530375762 415 DRLLN 419
Cdd:COG4886  368 TLGLL 372
LRRCT smart00082
Leucine rich repeat C-terminal domain;
395-446 1.80e-08

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 50.51  E-value: 1.80e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 530375762   395 NPWQCDCHLAYLFNWLQQYTDRLLNIQTYCAGPAYLKGQVVPALNEKqLVCP 446
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLLELLHSE-FKCP 51
LRRNT smart00013
Leucine rich repeat N-terminal domain;
21-53 5.11e-08

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 48.85  E-value: 5.11e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 530375762    21 PCPMGCDCFVQEVFCSDEELATVPLDIPPYTKN 53
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
95-419 9.24e-32

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 126.97  E-value: 9.24e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762  95 GLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNmlealpeGLFQHLAALESLHLQGNQLQALPRRLFQpLTHLKTL 174
Cdd:COG4886   70 SLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELAN-LTNLKEL 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762 175 NLAQNLLAQLPEELFHpLTSLQTLKLSNNALSGLPQgVFGKLGSLQELFLDSNNISELPPqVFSQLFCLERLWLQRNAIT 254
Cdd:COG4886  142 DLSNNQLTDLPEPLGN-LTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLT 218

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762 255 HLPLSIfASLGNLTFLSLQWNMLRVLPAglFAHTPCLVGLSLTHNQLETVAEgtFAHLSNLRSLMLSYNAITHLpagifr 334
Cdd:COG4886  219 DLPEPL-ANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDL------ 287

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762 335 DLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYT 414
Cdd:COG4886  288 KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLL 367


                 ....*
gi 530375762 415 DRLLN 419
Cdd:COG4886  368 TLGLL 372
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
126-380 9.28e-17

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 83.59  E-value: 9.28e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762 126 LTLNFNMLEALPEGLFqhlAALESLHLQGNQLQALPRRLfqPLThLKTLNLAQNLLAQLPEELfhPlTSLQTLKLSNNAL 205
Cdd:PRK15370 204 LILDNNELKSLPENLQ---GNIKTLYANSNQLTSIPATL--PDT-IQEMELSINRITELPERL--P-SALQSLDLFHNKI 274

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762 206 SGLPQGVfgkLGSLQELFLDSNNISELPPQVFSQLFcleRLWLQRNAITHLPLSIFAslgNLTFLSLQWNMLRVLPAGLf 285
Cdd:PRK15370 275 SCLPENL---PEELRYLSVYDNSIRTLPAHLPSGIT---HLNVQSNSLTALPETLPP---GLKTLEAGENALTSLPASL- 344

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762 286 ahTPCLVGLSLTHNQLeTVAEGTFAhlSNLRSLMLSYNAITHLPagifrdleelvklylgsNNLtalhPALFQnlskleL 365
Cdd:PRK15370 345 --PPELQVLDVSKNQI-TVLPETLP--PTITTLDVSRNALTNLP-----------------ENL----PAALQ------I 392

                        250
                 ....*....|....*
gi 530375762 366 LSLSKNQLTTLPEGI 380
Cdd:PRK15370 393 MQASRNNLVRLPESL 407
LRR_8 pfam13855
Leucine rich repeat;
294-349 3.50e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.69  E-value: 3.50e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 530375762  294 LSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNL 349
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 187-353 9.65e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 61.73  E-value: 9.65e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762 187 ELFHPLTSLQTLKLSNNALSGLPQgvFGKLGSLQELFLDSNNISELPPqvFSQLFCLERLWLQRNAITHLplSIFASLGN 266
Cdd:cd21340   18 DNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVV--EGLENLTN 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762 267 LTFLSLQW------NMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEgtFAHLSNLRSLMLSYNAIThlpagifrDLEELV 340
Cdd:cd21340   92 LEELHIENqrlppgEKLTFDPRSLAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQIS--------DLEELL 161

                        170
                 ....*....|...
gi 530375762 341 KLYLGSNNLTALH 353
Cdd:cd21340  162 DLLSSWPSLRELD 174
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 371-467 3.58e-10

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 63.18  E-value: 3.58e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762   371 NQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDRLLNIQ-TYCAGPAYLKGQvvPALNEKQLVCPVTR 449
Cdd:TIGR00864    5 NKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEaALCAGPGALAGQ--PLLGIPLLDSGCDE 82

                           90
                   ....*....|....*...
gi 530375762   450 DHLGfqvTWPDESKAGGS 467
Cdd:TIGR00864   83 EYVA---CLKDNSSGGGA 97
LRRCT smart00082
Leucine rich repeat C-terminal domain;
395-446 1.80e-08

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 50.51  E-value: 1.80e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 530375762   395 NPWQCDCHLAYLFNWLQQYTDRLLNIQTYCAGPAYLKGQVVPALNEKqLVCP 446
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLLELLHSE-FKCP 51
LRRNT smart00013
Leucine rich repeat N-terminal domain;
21-53 5.11e-08

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 48.85  E-value: 5.11e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 530375762    21 PCPMGCDCFVQEVFCSDEELATVPLDIPPYTKN 53
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
LRR smart00370
Leucine-rich repeats, outliers;
312-335 1.83e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.79  E-value: 1.83e-03
                           10        20
                   ....*....|....*....|....
gi 530375762   312 LSNLRSLMLSYNAITHLPAGIFRD 335
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 21-48 3.16e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 35.30  E-value: 3.16e-03
                          10        20
                  ....*....|....*....|....*...
gi 530375762   21 PCPMGCDCFVQEVFCSDEELATVPLDIP 48
Cdd:pfam01462   1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
95-419 9.24e-32

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 126.97  E-value: 9.24e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762  95 GLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNmlealpeGLFQHLAALESLHLQGNQLQALPRRLFQpLTHLKTL 174
Cdd:COG4886   70 SLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELAN-LTNLKEL 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762 175 NLAQNLLAQLPEELFHpLTSLQTLKLSNNALSGLPQgVFGKLGSLQELFLDSNNISELPPqVFSQLFCLERLWLQRNAIT 254
Cdd:COG4886  142 DLSNNQLTDLPEPLGN-LTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLT 218

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762 255 HLPLSIfASLGNLTFLSLQWNMLRVLPAglFAHTPCLVGLSLTHNQLETVAEgtFAHLSNLRSLMLSYNAITHLpagifr 334
Cdd:COG4886  219 DLPEPL-ANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDL------ 287

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762 335 DLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYT 414
Cdd:COG4886  288 KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLL 367


                 ....*
gi 530375762 415 DRLLN 419
Cdd:COG4886  368 TLGLL 372
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
31-329 1.19e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.37  E-value: 1.19e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762  31 QEVFCSDEELATVPLDIPPYT--KNIIFVETSFTTLETrAFGSNPNLTKVVFLNTQLCQFrPDAFGGLPRLEDLEVTGSS 108
Cdd:COG4886  116 ESLDLSGNQLTDLPEELANLTnlKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQ 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762 109 FLNLSTNIfSNLTSLGKLTLNFNMLEALPEGLFQhLAALESLHLQGNQLQALPRrlFQPLTHLKTLNLAQNLLAQLPEEL 188
Cdd:COG4886  194 ITDLPEPL-GNLTNLEELDLSGNQLTDLPEPLAN-LTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA 269

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762 189 fhPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLqrNAITHLPLSIFASLGNLT 268
Cdd:COG4886  270 --NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLL--LLLKGLLVTLTTLALSLS 345

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530375762 269 FLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLP 329
Cdd:COG4886  346 LLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLA 406
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
126-380 9.28e-17

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 83.59  E-value: 9.28e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762 126 LTLNFNMLEALPEGLFqhlAALESLHLQGNQLQALPRRLfqPLThLKTLNLAQNLLAQLPEELfhPlTSLQTLKLSNNAL 205
Cdd:PRK15370 204 LILDNNELKSLPENLQ---GNIKTLYANSNQLTSIPATL--PDT-IQEMELSINRITELPERL--P-SALQSLDLFHNKI 274

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762 206 SGLPQGVfgkLGSLQELFLDSNNISELPPQVFSQLFcleRLWLQRNAITHLPLSIFAslgNLTFLSLQWNMLRVLPAGLf 285
Cdd:PRK15370 275 SCLPENL---PEELRYLSVYDNSIRTLPAHLPSGIT---HLNVQSNSLTALPETLPP---GLKTLEAGENALTSLPASL- 344

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762 286 ahTPCLVGLSLTHNQLeTVAEGTFAhlSNLRSLMLSYNAITHLPagifrdleelvklylgsNNLtalhPALFQnlskleL 365
Cdd:PRK15370 345 --PPELQVLDVSKNQI-TVLPETLP--PTITTLDVSRNALTNLP-----------------ENL----PAALQ------I 392

                        250
                 ....*....|....*
gi 530375762 366 LSLSKNQLTTLPEGI 380
Cdd:PRK15370 393 MQASRNNLVRLPESL 407
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 92-395 8.96e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 74.50  E-value: 8.96e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762  92 AFGGLPRLEDLEVTGSSFL-NLSTNIFSNLTSLGKLTL-NFNMLEALPEGlfqHLAALESLHLQGNQLQALPRRLFQPLT 169
Cdd:PLN00113  88 AIFRLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLsNNNFTGSIPRG---SIPNLETLDLSNNMLSGEIPNDIGSFS 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762 170 HLKTLNLAQN-LLAQLPEELFHpLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNIS-ELPPQVfSQLFCLERLW 247
Cdd:PLN00113 165 SLKVLDLGGNvLVGKIPNSLTN-LTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSgEIPYEI-GGLTSLNHLD 242

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762 248 LQRNAITHLPLSIFASLGNLTFLSLQWNMLR-VLPAGLFAHTPcLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAIT 326
Cdd:PLN00113 243 LVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQK-LISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFT 321

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762 327 HLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLT-TLPEGIFDTNyNLFNLALHGN 395
Cdd:PLN00113 322 GKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSG-NLFKLILFSN 390
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 90-374 2.27e-13

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 72.96  E-value: 2.27e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762  90 PDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEA-LPEGLFQhLAALESLHLQGNQLQALPRRLFQPL 168
Cdd:PLN00113 253 PSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGeIPELVIQ-LQNLEILHLFSNNFTGKIPVALTSL 331

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762 169 THLKTLNLAQNLLA-QLPEELfHPLTSLQTLKLSNNALSG-LPQGVFGKlGSLQELFLDSNNISELPPQVFSQLFCLERL 246
Cdd:PLN00113 332 PRLQVLQLWSNKFSgEIPKNL-GKHNNLTVLDLSTNNLTGeIPEGLCSS-GNLFKLILFSNSLEGEIPKSLGACRSLRRV 409

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762 247 WLQRNAI--------THLPLSIFASLGNLTFL----SLQWNM-----LRVLPAGLFAHTPCLVG------LSLTHNQLET 303
Cdd:PLN00113 410 RLQDNSFsgelpsefTKLPLVYFLDISNNNLQgrinSRKWDMpslqmLSLARNKFFGGLPDSFGskrlenLDLSRNQFSG 489

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530375762 304 VAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLT 374
Cdd:PLN00113 490 AVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLS 560
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
99-395 2.87e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.89  E-value: 2.87e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762  99 LEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQ 178
Cdd:COG4886    2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762 179 NLLAQLPEELFHPLTSLQTLKLSNNALsglpqgvFGKLGSLQELFLDSNNISELPPQvFSQLFCLERLWLQRNAITHLPL 258
Cdd:COG4886   82 LSLLLLGLTDLGDLTNLTELDLSGNEE-------LSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPE 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762 259 SIfASLGNLTFLSLQWNMLRVLPAGLfahtpclvglslthnqletvaegtfAHLSNLRSLMLSYNAITHLPAGIFRdLEE 338
Cdd:COG4886  154 PL-GNLTNLKSLDLSNNQLTDLPEEL-------------------------GNLTNLKELDLSNNQITDLPEPLGN-LTN 206

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 530375762 339 LVKLYLGSNnltalhpalfqnlsklellslsknQLTTLPEGIFDTNyNLFNLALHGN 395
Cdd:COG4886  207 LEELDLSGN------------------------QLTDLPEPLANLT-NLETLDLSNN 238
LRR_8 pfam13855
Leucine rich repeat;
294-349 3.50e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.69  E-value: 3.50e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 530375762  294 LSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNL 349
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
150-378 3.73e-11

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 65.87  E-value: 3.73e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762 150 LHLQGNQLQALPRRLFQPLThlkTLNLAQNLLAQLPEELFhplTSLQTLKLSNNALSGLPQGVfgkLGSLQELFLDSNNI 229
Cdd:PRK15370 183 LRLKILGLTTIPACIPEQIT---TLILDNNELKSLPENLQ---GNIKTLYANSNQLTSIPATL---PDTIQEMELSINRI 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762 230 SELPPQVFSqlfCLERLWLQRNAITHLPLSIfasLGNLTFLSLQWNMLRVLPAglfaHTPClvglSLTHnqletvaegtf 309
Cdd:PRK15370 254 TELPERLPS---ALQSLDLFHNKISCLPENL---PEELRYLSVYDNSIRTLPA----HLPS----GITH----------- 308

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530375762 310 ahlsnlrsLMLSYNAITHLPAGIFRDLEELVKlylGSNNLTALH---PALFQNLSKLEllslskNQLTTLPE 378
Cdd:PRK15370 309 --------LNVQSNSLTALPETLPPGLKTLEA---GENALTSLPaslPPELQVLDVSK------NQITVLPE 363
LRR_8 pfam13855
Leucine rich repeat;
169-229 8.20e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.53  E-value: 8.20e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530375762  169 THLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNI 229
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 187-353 9.65e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 61.73  E-value: 9.65e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762 187 ELFHPLTSLQTLKLSNNALSGLPQgvFGKLGSLQELFLDSNNISELPPqvFSQLFCLERLWLQRNAITHLplSIFASLGN 266
Cdd:cd21340   18 DNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVV--EGLENLTN 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762 267 LTFLSLQW------NMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEgtFAHLSNLRSLMLSYNAIThlpagifrDLEELV 340
Cdd:cd21340   92 LEELHIENqrlppgEKLTFDPRSLAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQIS--------DLEELL 161

                        170
                 ....*....|...
gi 530375762 341 KLYLGSNNLTALH 353
Cdd:cd21340  162 DLLSSWPSLRELD 174
LRR_8 pfam13855
Leucine rich repeat;
147-205 2.73e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.99  E-value: 2.73e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 530375762  147 LESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNAL 205
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 371-467 3.58e-10

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 63.18  E-value: 3.58e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762   371 NQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDRLLNIQ-TYCAGPAYLKGQvvPALNEKQLVCPVTR 449
Cdd:TIGR00864    5 NKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEaALCAGPGALAGQ--PLLGIPLLDSGCDE 82

                           90
                   ....*....|....*...
gi 530375762   450 DHLGfqvTWPDESKAGGS 467
Cdd:TIGR00864   83 EYVA---CLKDNSSGGGA 97
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 29-350 9.82e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 61.40  E-value: 9.82e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762  29 FVQEVFCSDEELA-TVPLDIPPYTKNIIFVETS---FTTLETRafGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEV 104
Cdd:PLN00113  94 YIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSnnnFTGSIPR--GSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDL 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762 105 TGSSFLNLSTNIFSNLTSLGKLTLNFNMLEA-LPEGLFQhLAALESLHLQGNQLQA-LPRRLFQpLTHLKTLNLA-QNLL 181
Cdd:PLN00113 172 GGNVLVGKIPNSLTNLTSLEFLTLASNQLVGqIPRELGQ-MKSLKWIYLGYNNLSGeIPYEIGG-LTSLNHLDLVyNNLT 249

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762 182 AQLPEELFHpLTSLQTLKLSNNALSG-LPQGVFGkLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRN--------A 252
Cdd:PLN00113 250 GPIPSSLGN-LKNLQYLFLYQNKLSGpIPPSIFS-LQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNnftgkipvA 327

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762 253 ITHLP-----------LS--IFASLG---NLTFLSLQWNMLR-VLPAGLfAHTPCLVGLSLTHNQLETVAEGTFAHLSNL 315
Cdd:PLN00113 328 LTSLPrlqvlqlwsnkFSgeIPKNLGkhnNLTVLDLSTNNLTgEIPEGL-CSSGNLFKLILFSNSLEGEIPKSLGACRSL 406

                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 530375762 316 RSLMLSYNAIT-HLPAGiFRDLEELVKLYLGSNNLT 350
Cdd:PLN00113 407 RRVRLQDNSFSgELPSE-FTKLPLVYFLDISNNNLQ 441
LRR_8 pfam13855
Leucine rich repeat;
193-253 1.60e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.07  E-value: 1.60e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530375762  193 TSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAI 253
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 149-356 9.30e-09

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 56.98  E-value: 9.30e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762 149 SLHLQGNQL-QALPRRLFQPLTHLKTLNLAQNLLA-----QLPEELfHPLTSLQTLKLSNNALSGLPQGV------FGKL 216
Cdd:cd00116    2 QLSLKGELLkTERATELLPKLLCLQVLRLEGNTLGeeaakALASAL-RPQPSLKELCLSLNETGRIPRGLqsllqgLTKG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762 217 GSLQELFLDSNNISELPPQVF---SQLFCLERLWLQRNAITHLPLSIFA-SLG----NLTFLSLQWNMLRVLP----AGL 284
Cdd:cd00116   81 CGLQELDLSDNALGPDGCGVLeslLRSSSLQELKLNNNGLGDRGLRLLAkGLKdlppALEKLVLGRNRLEGAScealAKA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762 285 FAHTPCLVGLSLTHNQL-----ETVAEGtFAHLSNLRSLMLSYNAITHLP----AGIFRDLEELVKLYLGSNNLT----- 350
Cdd:cd00116  161 LRANRDLKELNLANNGIgdagiRALAEG-LKANCNLEVLDLNNNGLTDEGasalAETLASLKSLEVLNLGDNNLTdagaa 239


                 ....*.
gi 530375762 351 ALHPAL 356
Cdd:cd00116  240 ALASAL 245
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
102-396 1.19e-08

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 57.86  E-value: 1.19e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762 102 LEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPeglfqhlAALESLHLQGNQLQALPrrLFQPltHLKTLNLAQNLL 181
Cdd:PRK15387 206 LNVGESGLTTLPDCLPAHITTLVIPDNNLTSLPALP-------PELRTLEVSGNQLTSLP--VLPP--GLLELSIFSNPL 274

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762 182 AQLPEELfhplTSLQTLKLSNNALSGLPQGVFGklgsLQELFLDSNNISELPpqVFSQLFCleRLWLQRNAITHLPlSIF 261
Cdd:PRK15387 275 THLPALP----SGLCKLWIFGNQLTSLPVLPPG----LQELSVSDNQLASLP--ALPSELC--KLWAYNNQLTSLP-TLP 341

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762 262 ASLGNLTFLSLQWNMLRVLPAGLFAhtpclvgLSLTHNQLETVAegtfAHLSNLRSLMLSYNAITHLPAGIfrdlEELVK 341
Cdd:PRK15387 342 SGLQELSVSDNQLASLPTLPSELYK-------LWAYNNRLTSLP----ALPSGLKELIVSGNRLTSLPVLP----SELKE 406

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 530375762 342 LYLGSNNLTALhPALfqnLSKLELLSLSKNQLTTLPEGIFDTNYNLfNLALHGNP 396
Cdd:PRK15387 407 LMVSGNRLTSL-PML---PSGLLSLSVYRNQLTRLPESLIHLSSET-TVNLEGNP 456
LRRCT smart00082
Leucine rich repeat C-terminal domain;
395-446 1.80e-08

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 50.51  E-value: 1.80e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 530375762   395 NPWQCDCHLAYLFNWLQQYTDRLLNIQTYCAGPAYLKGQVVPALNEKqLVCP 446
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGPLLELLHSE-FKCP 51
LRR_8 pfam13855
Leucine rich repeat;
121-181 3.50e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.22  E-value: 3.50e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530375762  121 TSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLL 181
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRNT smart00013
Leucine rich repeat N-terminal domain;
21-53 5.11e-08

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 48.85  E-value: 5.11e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 530375762    21 PCPMGCDCFVQEVFCSDEELATVPLDIPPYTKN 53
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
30-259 5.13e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 55.86  E-value: 5.13e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762  30 VQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNLtkVVFLNTQLCQfrPDAfggLPR-LEDLEVTGSS 108
Cdd:PRK15370 222 IKTLYANSNQLTSIPATLPDTIQEMELSINRITELPERLPSALQSL--DLFHNKISCL--PEN---LPEeLRYLSVYDNS 294

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762 109 FLNLSTNIFSNLTslgKLTLNFNMLEALPEGLFQHLAALESlhlQGNQLQALPRRLfqPlTHLKTLNLAQNLLAQLPEEL 188
Cdd:PRK15370 295 IRTLPAHLPSGIT---HLNVQSNSLTALPETLPPGLKTLEA---GENALTSLPASL--P-PELQVLDVSKNQITVLPETL 365

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530375762 189 fhPLTsLQTLKLSNNALSGLPQGVFGKLGSLQELFldsNNISELPPQVFSqlFCLERLWLQRNAITHLPLS 259
Cdd:PRK15370 366 --PPT-ITTLDVSRNALTNLPENLPAALQIMQASR---NNLVRLPESLPH--FRGEGPQPTRIIVEYNPFS 428
LRR_8 pfam13855
Leucine rich repeat;
97-157 9.70e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 9.70e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 530375762   97 PRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQL 157
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 138-257 1.21e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.48  E-value: 1.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762 138 EGLfQHLAALESLHLQGNQLqalpRRL--FQPLTHLKTLNLAQNLLA-------------------QLPEE---LFHPLT 193
Cdd:cd21340   40 ENL-EFLTNLTHLYLQNNQI----EKIenLENLVNLKKLYLGGNRISvveglenltnleelhienqRLPPGeklTFDPRS 114

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 530375762 194 ------SLQTLKLSNNALSGLPQgvFGKLGSLQELFLDSNNISELPP--QVFSQLFCLERLWLQRNAITHLP 257
Cdd:cd21340  115 laalsnSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
218-277 3.27e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 3.27e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762  218 SLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNML 277
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
313-359 3.33e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 3.33e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 530375762  313 SNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQN 359
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSG 47
LRR_8 pfam13855
Leucine rich repeat;
266-325 3.61e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 3.61e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762  266 NLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAI 325
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
243-301 9.93e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 9.93e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 530375762  243 LERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQL 301
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 122-277 6.43e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.96  E-value: 6.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762 122 SLGKLTLNFNMLEALP----EGLFQHLAALESLHLQGNQLQ-ALPRRLFQPL---THLKTLNLAQNLL----AQLPEELF 189
Cdd:cd00116  138 ALEKLVLGRNRLEGAScealAKALRANRDLKELNLANNGIGdAGIRALAEGLkanCNLEVLDLNNNGLtdegASALAETL 217

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762 190 HPLTSLQTLKLSNNALSGLPqgvfgklgslqelfldsnnISELPPQVFSQLFCLERLWLQRNAITHL-------PLSIFA 262
Cdd:cd00116  218 ASLKSLEVLNLGDNNLTDAG-------------------AAALASALLSPNISLLTLSLSCNDITDDgakdlaeVLAEKE 278

                        170
                 ....*....|....*
gi 530375762 263 SlgnLTFLSLQWNML 277
Cdd:cd00116  279 S---LLELDLRGNKF 290
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 197-395 9.30e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.14  E-value: 9.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762 197 TLKLSNNALSGLPQGVFGKLGSLQELFLDSNNIS-ELPPQVFS----------------------QLFCLERLWLQRNAI 253
Cdd:PLN00113  73 SIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSgPIPDDIFTtssslrylnlsnnnftgsiprgSIPNLETLDLSNNML 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762 254 T-HLPLSIfASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAIT-HLPAG 331
Cdd:PLN00113 153 SgEIPNDI-GSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSgEIPYE 231

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 530375762 332 IFRdLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLT-TLPEGIFDTNyNLFNLALHGN 395
Cdd:PLN00113 232 IGG-LTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQ-KLISLDLSDN 294
LRR smart00370
Leucine-rich repeats, outliers;
312-335 1.83e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.79  E-value: 1.83e-03
                           10        20
                   ....*....|....*....|....
gi 530375762   312 LSNLRSLMLSYNAITHLPAGIFRD 335
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
312-335 1.83e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.79  E-value: 1.83e-03
                           10        20
                   ....*....|....*....|....
gi 530375762   312 LSNLRSLMLSYNAITHLPAGIFRD 335
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 117-209 1.83e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.77  E-value: 1.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762 117 FSNLTSLGKLTLNFNMLEALpEGLfQHLAALESLHLQGNQLQ-------------ALPRRL---------------FQPL 168
Cdd:cd21340   64 LENLVNLKKLYLGGNRISVV-EGL-ENLTNLEELHIENQRLPpgekltfdprslaALSNSLrvlnisgnnidslepLAPL 141

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 530375762 169 THLKTLNLAQNLLAQLPE--ELFHPLTSLQTLKLSNNALSGLP 209
Cdd:cd21340  142 RNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKP 184
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 213-351 2.82e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 40.16  E-value: 2.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762 213 FGKLGSLQELFLDSNNIS----ELPPQVFSQLFCLERLWLQRNAITHLPLSIFASL--GNLTFLSLQWNMLRVLPAGLFA 286
Cdd:COG5238  176 ALQNNSVETVYLGCNQIGdegiEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEAlkGNKSLTTLDLSNNQIGDEGVIA 255

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 530375762 287 ------HTPCLVGLSLTHNQL-ETVAEGTFAHLS---NLRSLMLSYNAITHLPA-GIFRDLEE---LVKLYLGSNNLTA 351
Cdd:COG5238  256 laealkNNTTVETLYLSGNQIgAEGAIALAKALQgntTLTSLDLSVNRIGDEGAiALAEGLQGnktLHTLNLAYNGIGA 334
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 21-48 3.16e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 35.30  E-value: 3.16e-03
                          10        20
                  ....*....|....*....|....*...
gi 530375762   21 PCPMGCDCFVQEVFCSDEELATVPLDIP 48
Cdd:pfam01462   1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
PLN03150 PLN03150
hypothetical protein; Provisional
 178-265 4.69e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 39.80  E-value: 4.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 530375762 178 QNLLAQLPEELfHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAIT-HL 256
Cdd:PLN03150 428 QGLRGFIPNDI-SKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSgRV 506


                 ....*....
gi 530375762 257 PlsifASLG 265
Cdd:PLN03150 507 P----AALG 511
PLN03150 PLN03150
hypothetical protein; Provisional
 141-216 9.50e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 38.64  E-value: 9.50e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 530375762 141 FQHLaalESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSG-LPQGVFGKL 216
Cdd:PLN03150 441 LRHL---QSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGrVPAALGGRL 514
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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