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Conserved domains on  [gi|545368573|ref|XP_005649067|]
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hypothetical protein COCSUDRAFT_61953 [Coccomyxa subellipsoidea C-169]

Protein Classification

DUF2945 domain-containing protein( domain architecture ID 10567668)

DUF2945 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Hva1_TUDOR pfam11160
Hypervirulence associated proteins TUDOR domain; Family members include HVA1 ...
 18-67 1.21e-11

Hypervirulence associated proteins TUDOR domain; Family members include HVA1 (hypervirulence-associated protein 1) whose absence is associated with a hypervirulent phenotype in mice. Metabolomics analysis suggests that when HVA1 is absent there is a block in the citric acid cycle, while structural analysis of the Hva1 protein suggests a potential interaction with NADPH. The structural architecture of Hva1 bears similarity with Tudor domains.


:

Pssm-ID: 431691 [Multi-domain]  Cd Length: 59  Bit Score: 54.04  E-value: 1.21e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 545368573  18 GDFVSTKYRGGTREGVVERIAKTPEEH--------PHPPKVIFTNQR-GKEVAHNPSTL 67
Cdd:pfam11160  1 GDKVSWKWGGGTAEGKVVEVLTEETEAkgvtvnasEDDPAYEIESDKtGKDVVHKPSEL 59
 
Name Accession Description Interval E-value
Hva1_TUDOR pfam11160
Hypervirulence associated proteins TUDOR domain; Family members include HVA1 ...
 18-67 1.21e-11

Hypervirulence associated proteins TUDOR domain; Family members include HVA1 (hypervirulence-associated protein 1) whose absence is associated with a hypervirulent phenotype in mice. Metabolomics analysis suggests that when HVA1 is absent there is a block in the citric acid cycle, while structural analysis of the Hva1 protein suggests a potential interaction with NADPH. The structural architecture of Hva1 bears similarity with Tudor domains.


Pssm-ID: 431691 [Multi-domain]  Cd Length: 59  Bit Score: 54.04  E-value: 1.21e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 545368573  18 GDFVSTKYRGGTREGVVERIAKTPEEH--------PHPPKVIFTNQR-GKEVAHNPSTL 67
Cdd:pfam11160  1 GDKVSWKWGGGTAEGKVVEVLTEETEAkgvtvnasEDDPAYEIESDKtGKDVVHKPSEL 59
 
Name Accession Description Interval E-value
Hva1_TUDOR pfam11160
Hypervirulence associated proteins TUDOR domain; Family members include HVA1 ...
 18-67 1.21e-11

Hypervirulence associated proteins TUDOR domain; Family members include HVA1 (hypervirulence-associated protein 1) whose absence is associated with a hypervirulent phenotype in mice. Metabolomics analysis suggests that when HVA1 is absent there is a block in the citric acid cycle, while structural analysis of the Hva1 protein suggests a potential interaction with NADPH. The structural architecture of Hva1 bears similarity with Tudor domains.


Pssm-ID: 431691 [Multi-domain]  Cd Length: 59  Bit Score: 54.04  E-value: 1.21e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 545368573  18 GDFVSTKYRGGTREGVVERIAKTPEEH--------PHPPKVIFTNQR-GKEVAHNPSTL 67
Cdd:pfam11160  1 GDKVSWKWGGGTAEGKVVEVLTEETEAkgvtvnasEDDPAYEIESDKtGKDVVHKPSEL 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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