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Conserved domains on  [gi|551527351|ref|XP_005815150|]
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germ cell-specific gene 1-like protein [Xiphophorus maculatus]

Protein Classification

GSG-1 and PMP22_Claudin domain-containing protein( domain architecture ID 10544661)

GSG-1 and PMP22_Claudin domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GSG-1 pfam07803
GSG1-like protein; This family contains sequences bearing similarity to a region of GSG1, a ...
 5-117 1.89e-62

GSG1-like protein; This family contains sequences bearing similarity to a region of GSG1, a protein specifically expressed in testicular germ cells. It is possible that overexpression of the human homolog may be involved in tumourigenesis of human testicular germ cell tumours. The region in question has four highly-conserved cysteine residues.


:

Pssm-ID: 462270  Cd Length: 109  Bit Score: 193.23  E-value: 1.89e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551527351    5 RGRRASLAITLNFVALAFAVSAVTTSYWCEGTRKVAKPFCSGppvqMKQMYCIRFNSTNLNDSRQVQYIFETGEEKFILR 84
Cdd:pfam07803   1 RRRRALLSLILNLLALALSTTALLSSYWCEGTQKVPKPLCGK----GKQTNCIDFGSSNTSDSEVVQYIWETGDDRFSFR 76

                          90       100       110
                  ....*....|....*....|....*....|...
gi 551527351   85 KFHTGIFYSCEQAVDMNGFDCRSFAEIAPEHQR 117
Cdd:pfam07803  77 YFHTGIWLSCEENIEGPGEKCRSFIELTPASER 109
PMP22_Claudin super family cl21598
PMP-22/EMP/MP20/Claudin family;
129-220 6.13e-04

PMP-22/EMP/MP20/Claudin family;


The actual alignment was detected with superfamily member pfam13903:

Pssm-ID: 473919 [Multi-domain]  Cd Length: 191  Bit Score: 40.10  E-value: 6.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551527351  129 LYLALLFVGGVLMIleqsrCFSVMNKLKLSAFAAMCTALSGLCGMVAHMMFTTIFHLSVSMGPEDWRPK-----TWDYSW 203
Cdd:pfam13903  96 LSLVLIVCGVVCGL-----LALPKQSVFLLLAAGILFLLSGVLGLLGVIVFGQSVKLVFEEYFRQWMPEhqnnvRISFGW 170

                          90
                  ....*....|....*..
gi 551527351  204 SYALAWCSFGTCMGSAV 220
Cdd:pfam13903 171 SFALAWAGVVLSLLAGL 187
 
Name Accession Description Interval E-value
GSG-1 pfam07803
GSG1-like protein; This family contains sequences bearing similarity to a region of GSG1, a ...
 5-117 1.89e-62

GSG1-like protein; This family contains sequences bearing similarity to a region of GSG1, a protein specifically expressed in testicular germ cells. It is possible that overexpression of the human homolog may be involved in tumourigenesis of human testicular germ cell tumours. The region in question has four highly-conserved cysteine residues.


Pssm-ID: 462270  Cd Length: 109  Bit Score: 193.23  E-value: 1.89e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551527351    5 RGRRASLAITLNFVALAFAVSAVTTSYWCEGTRKVAKPFCSGppvqMKQMYCIRFNSTNLNDSRQVQYIFETGEEKFILR 84
Cdd:pfam07803   1 RRRRALLSLILNLLALALSTTALLSSYWCEGTQKVPKPLCGK----GKQTNCIDFGSSNTSDSEVVQYIWETGDDRFSFR 76

                          90       100       110
                  ....*....|....*....|....*....|...
gi 551527351   85 KFHTGIFYSCEQAVDMNGFDCRSFAEIAPEHQR 117
Cdd:pfam07803  77 YFHTGIWLSCEENIEGPGEKCRSFIELTPASER 109
Claudin_2 pfam13903
PMP-22/EMP/MP20/Claudin tight junction; Members of this family are claudins, that form tight ...
 129-220 6.13e-04

PMP-22/EMP/MP20/Claudin tight junction; Members of this family are claudins, that form tight junctions between cells.


Pssm-ID: 372799 [Multi-domain]  Cd Length: 191  Bit Score: 40.10  E-value: 6.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551527351  129 LYLALLFVGGVLMIleqsrCFSVMNKLKLSAFAAMCTALSGLCGMVAHMMFTTIFHLSVSMGPEDWRPK-----TWDYSW 203
Cdd:pfam13903  96 LSLVLIVCGVVCGL-----LALPKQSVFLLLAAGILFLLSGVLGLLGVIVFGQSVKLVFEEYFRQWMPEhqnnvRISFGW 170

                          90
                  ....*....|....*..
gi 551527351  204 SYALAWCSFGTCMGSAV 220
Cdd:pfam13903 171 SFALAWAGVVLSLLAGL 187
 
Name Accession Description Interval E-value
GSG-1 pfam07803
GSG1-like protein; This family contains sequences bearing similarity to a region of GSG1, a ...
 5-117 1.89e-62

GSG1-like protein; This family contains sequences bearing similarity to a region of GSG1, a protein specifically expressed in testicular germ cells. It is possible that overexpression of the human homolog may be involved in tumourigenesis of human testicular germ cell tumours. The region in question has four highly-conserved cysteine residues.


Pssm-ID: 462270  Cd Length: 109  Bit Score: 193.23  E-value: 1.89e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551527351    5 RGRRASLAITLNFVALAFAVSAVTTSYWCEGTRKVAKPFCSGppvqMKQMYCIRFNSTNLNDSRQVQYIFETGEEKFILR 84
Cdd:pfam07803   1 RRRRALLSLILNLLALALSTTALLSSYWCEGTQKVPKPLCGK----GKQTNCIDFGSSNTSDSEVVQYIWETGDDRFSFR 76

                          90       100       110
                  ....*....|....*....|....*....|...
gi 551527351   85 KFHTGIFYSCEQAVDMNGFDCRSFAEIAPEHQR 117
Cdd:pfam07803  77 YFHTGIWLSCEENIEGPGEKCRSFIELTPASER 109
Claudin_2 pfam13903
PMP-22/EMP/MP20/Claudin tight junction; Members of this family are claudins, that form tight ...
 129-220 6.13e-04

PMP-22/EMP/MP20/Claudin tight junction; Members of this family are claudins, that form tight junctions between cells.


Pssm-ID: 372799 [Multi-domain]  Cd Length: 191  Bit Score: 40.10  E-value: 6.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 551527351  129 LYLALLFVGGVLMIleqsrCFSVMNKLKLSAFAAMCTALSGLCGMVAHMMFTTIFHLSVSMGPEDWRPK-----TWDYSW 203
Cdd:pfam13903  96 LSLVLIVCGVVCGL-----LALPKQSVFLLLAAGILFLLSGVLGLLGVIVFGQSVKLVFEEYFRQWMPEhqnnvRISFGW 170

                          90
                  ....*....|....*..
gi 551527351  204 SYALAWCSFGTCMGSAV 220
Cdd:pfam13903 171 SFALAWAGVVLSLLAGL 187
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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