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Conserved domains on  [gi|554553885|ref|XP_005871409|]
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PREDICTED: alpha-2-macroglobulin-like [Myotis brandtii]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MG3 pfam17791
Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement ...
 143-233 6.01e-28

Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement components C3, C4 and C5.


:

Pssm-ID: 465509  Cd Length: 83  Bit Score: 103.51  E-value: 6.01e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554553885  143 EFVLPKFEVKVTVPKIITISDEEVKVSVCGLYTYGKPVPGHVTMSMCRKYYNPSNCFGGESQALCEKlsqklnsqGCVSQ 222
Cdd:pfam17791   1 EYVLPKFEVKVEVPKFISVKDEEFQVTICAKYTYGKPVKGKAYVTLCLKDDSKRKCFESFSKELDKD--------GCGSA 72

                          90
                  ....*....|.
gi 554553885  223 QVKTKVFQMKR 233
Cdd:pfam17791  73 SLSTEEFQLTF 83
MG2 pfam01835
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. ...
 49-141 6.71e-27

MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain is termed macroglobulin-like (MG) domain 2 and in Salmonella enterica ser A2Ms, this is domain 4.


:

Pssm-ID: 426464 [Multi-domain]  Cd Length: 95  Bit Score: 101.24  E-value: 6.71e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554553885   49 VFVQTDKPIYKPGQTVKFRVVSLDENFHPLNELIPLVSIEDPKGNRIAQWQKVKLESGLKQLAFPLSSEPFLGSYKV-LV 127
Cdd:pfam01835   2 AFVYTDRGIYRPGETVHFKGLLRDQDLRPLAGLPVTLTVTDPDGNEVRRLPLTTDEFGGFSGSFPLPETAPTGTYTVvLR 81

                          90
                  ....*....|....
gi 554553885  128 QEESGETAEHPFTV 141
Cdd:pfam01835  82 DGAGGSLGSGSFRV 95
MG4 super family cl39290
Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins.
 270-290 4.56e-04

Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins.


The actual alignment was detected with superfamily member pfam17789:

Pssm-ID: 465507  Cd Length: 95  Bit Score: 38.77  E-value: 4.56e-04
                          10        20
                  ....*....|....*....|.
gi 554553885  270 LSFVKVDPHFRQGVPFFGQVE 290
Cdd:pfam17789   1 ITFEKTPKYFKPGLPFSGQVL 21
 
Name Accession Description Interval E-value
MG3 pfam17791
Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement ...
 143-233 6.01e-28

Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement components C3, C4 and C5.


Pssm-ID: 465509  Cd Length: 83  Bit Score: 103.51  E-value: 6.01e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554553885  143 EFVLPKFEVKVTVPKIITISDEEVKVSVCGLYTYGKPVPGHVTMSMCRKYYNPSNCFGGESQALCEKlsqklnsqGCVSQ 222
Cdd:pfam17791   1 EYVLPKFEVKVEVPKFISVKDEEFQVTICAKYTYGKPVKGKAYVTLCLKDDSKRKCFESFSKELDKD--------GCGSA 72

                          90
                  ....*....|.
gi 554553885  223 QVKTKVFQMKR 233
Cdd:pfam17791  73 SLSTEEFQLTF 83
MG2 pfam01835
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. ...
 49-141 6.71e-27

MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain is termed macroglobulin-like (MG) domain 2 and in Salmonella enterica ser A2Ms, this is domain 4.


Pssm-ID: 426464 [Multi-domain]  Cd Length: 95  Bit Score: 101.24  E-value: 6.71e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554553885   49 VFVQTDKPIYKPGQTVKFRVVSLDENFHPLNELIPLVSIEDPKGNRIAQWQKVKLESGLKQLAFPLSSEPFLGSYKV-LV 127
Cdd:pfam01835   2 AFVYTDRGIYRPGETVHFKGLLRDQDLRPLAGLPVTLTVTDPDGNEVRRLPLTTDEFGGFSGSFPLPETAPTGTYTVvLR 81

                          90
                  ....*....|....
gi 554553885  128 QEESGETAEHPFTV 141
Cdd:pfam01835  82 DGAGGSLGSGSFRV 95
YfaS COG2373
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ...
 49-270 8.68e-19

Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];


Pssm-ID: 441940 [Multi-domain]  Cd Length: 1605  Bit Score: 87.06  E-value: 8.68e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554553885   49 VFVQTDKPIYKPGQTVKFRVVSLDENFHPLNELiPL-VSIEDPKGNRIAQWQKVKLESGLKQLAFPLSSEPFLGSYKVLV 127
Cdd:COG2373   371 AFLFTDRGIYRPGETVHLKALLRDADGKAPAGL-PLtLELTDPDGKEVRRQTLTLNEFGGYSFSFPLPEDAPTGTWRLEL 449

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554553885  128 QEESGET-AEHPFTVEEFVLPKFEVKVTVPKIITISDEEVKVSVCGLYTYGKPVPG-HVTMSMCRK-------------Y 192
Cdd:COG2373   450 YVDPKPAlGSKSFRVEEFKPPRFKVDLTLDKEPLKPGDPVTVTVDARYLFGAPAAGlKVEGEVTLRpartafpgypgyrF 529

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 554553885  193 YNPSNCFGGESQALcekLSQKLNSQGCVSQQVKTKvfQMKREGLKMELEVEAKIKEEGteveltGRglsEITRTITQL 270
Cdd:COG2373   530 GDPDEEFEPEELDL---GEGTLDADGKASLSLPLP--DAPDAPGPLRATVEASVFESG------GR---PVTRSATVP 593
MG4 pfam17789
Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins.
 270-290 4.56e-04

Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins.


Pssm-ID: 465507  Cd Length: 95  Bit Score: 38.77  E-value: 4.56e-04
                          10        20
                  ....*....|....*....|.
gi 554553885  270 LSFVKVDPHFRQGVPFFGQVE 290
Cdd:pfam17789   1 ITFEKTPKYFKPGLPFSGQVL 21
YfaS COG2373
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ...
 51-117 3.20e-03

Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];


Pssm-ID: 441940 [Multi-domain]  Cd Length: 1605  Bit Score: 39.29  E-value: 3.20e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 554553885   51 VQTDKPIYKPGQTVKFRVVSldenfhplneliP-----LVSIEdpkGNRIAQWQKVKLESGLKQLAFPLSSE 117
Cdd:COG2373   728 LSLDKESYKPGETAKLLIQS------------PfagraLVTVE---RDGVLETQWVDVKGGGTTVEIPVTED 784
 
Name Accession Description Interval E-value
MG3 pfam17791
Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement ...
 143-233 6.01e-28

Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement components C3, C4 and C5.


Pssm-ID: 465509  Cd Length: 83  Bit Score: 103.51  E-value: 6.01e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554553885  143 EFVLPKFEVKVTVPKIITISDEEVKVSVCGLYTYGKPVPGHVTMSMCRKYYNPSNCFGGESQALCEKlsqklnsqGCVSQ 222
Cdd:pfam17791   1 EYVLPKFEVKVEVPKFISVKDEEFQVTICAKYTYGKPVKGKAYVTLCLKDDSKRKCFESFSKELDKD--------GCGSA 72

                          90
                  ....*....|.
gi 554553885  223 QVKTKVFQMKR 233
Cdd:pfam17791  73 SLSTEEFQLTF 83
MG2 pfam01835
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. ...
 49-141 6.71e-27

MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain is termed macroglobulin-like (MG) domain 2 and in Salmonella enterica ser A2Ms, this is domain 4.


Pssm-ID: 426464 [Multi-domain]  Cd Length: 95  Bit Score: 101.24  E-value: 6.71e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554553885   49 VFVQTDKPIYKPGQTVKFRVVSLDENFHPLNELIPLVSIEDPKGNRIAQWQKVKLESGLKQLAFPLSSEPFLGSYKV-LV 127
Cdd:pfam01835   2 AFVYTDRGIYRPGETVHFKGLLRDQDLRPLAGLPVTLTVTDPDGNEVRRLPLTTDEFGGFSGSFPLPETAPTGTYTVvLR 81

                          90
                  ....*....|....
gi 554553885  128 QEESGETAEHPFTV 141
Cdd:pfam01835  82 DGAGGSLGSGSFRV 95
YfaS COG2373
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ...
 49-270 8.68e-19

Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];


Pssm-ID: 441940 [Multi-domain]  Cd Length: 1605  Bit Score: 87.06  E-value: 8.68e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554553885   49 VFVQTDKPIYKPGQTVKFRVVSLDENFHPLNELiPL-VSIEDPKGNRIAQWQKVKLESGLKQLAFPLSSEPFLGSYKVLV 127
Cdd:COG2373   371 AFLFTDRGIYRPGETVHLKALLRDADGKAPAGL-PLtLELTDPDGKEVRRQTLTLNEFGGYSFSFPLPEDAPTGTWRLEL 449

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554553885  128 QEESGET-AEHPFTVEEFVLPKFEVKVTVPKIITISDEEVKVSVCGLYTYGKPVPG-HVTMSMCRK-------------Y 192
Cdd:COG2373   450 YVDPKPAlGSKSFRVEEFKPPRFKVDLTLDKEPLKPGDPVTVTVDARYLFGAPAAGlKVEGEVTLRpartafpgypgyrF 529

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 554553885  193 YNPSNCFGGESQALcekLSQKLNSQGCVSQQVKTKvfQMKREGLKMELEVEAKIKEEGteveltGRglsEITRTITQL 270
Cdd:COG2373   530 GDPDEEFEPEELDL---GEGTLDADGKASLSLPLP--DAPDAPGPLRATVEASVFESG------GR---PVTRSATVP 593
MG4 pfam17789
Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins.
 270-290 4.56e-04

Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins.


Pssm-ID: 465507  Cd Length: 95  Bit Score: 38.77  E-value: 4.56e-04
                          10        20
                  ....*....|....*....|.
gi 554553885  270 LSFVKVDPHFRQGVPFFGQVE 290
Cdd:pfam17789   1 ITFEKTPKYFKPGLPFSGQVL 21
YfaS COG2373
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ...
 51-117 3.20e-03

Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];


Pssm-ID: 441940 [Multi-domain]  Cd Length: 1605  Bit Score: 39.29  E-value: 3.20e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 554553885   51 VQTDKPIYKPGQTVKFRVVSldenfhplneliP-----LVSIEdpkGNRIAQWQKVKLESGLKQLAFPLSSE 117
Cdd:COG2373   728 LSLDKESYKPGETAKLLIQS------------PfagraLVTVE---RDGVLETQWVDVKGGGTTVEIPVTED 784
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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