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Conserved domains on  [gi|564329914|ref|XP_006229869|]
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BRCA2-interacting transcriptional repressor EMSY isoform X7 [Rattus norvegicus]

Protein Classification

ENT and PHA03247 domain-containing protein( domain architecture ID 13690837)

ENT and PHA03247 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ENT pfam03735
ENT domain; This presumed domain is named after Emsy N Terminus (ENT). Emsy is a protein that ...
 17-81 6.01e-28

ENT domain; This presumed domain is named after Emsy N Terminus (ENT). Emsy is a protein that is amplified in breast cancer and interacts with BRCA2. The N terminus of this protein is found to be similar to other vertebrate and plant proteins of unknown function. This domain has a completely conserved histidine residue that may be functionally important.


:

Pssm-ID: 461032  Cd Length: 71  Bit Score: 107.65  E-value: 6.01e-28
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564329914    17 KRILRKLELEAYAGVISALRAQGD-LTKEKKDLLGELSKVLSISTERHRAEVRRAVNDERLTTIAH 81
Cdd:pfam03735    1 KRQLRKLELEAYSSVLRAFRAQGDaLSWEKEKLLTELRKELNISDERHRAELRRVVNDERLKTIRE 66
PABP-1234 super family cl31127
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 936-1080 1.80e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


The actual alignment was detected with superfamily member TIGR01628:

Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 42.49  E-value: 1.80e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329914   936 KQQKLSQPQLEQTQLQVKTLQCFQTKQKQTIHLQ-ADQLQHKLTQMPQLSVRHQKLTPL---QQEQAQPKPDAQHTQHTV 1011
Cdd:TIGR01628  364 KEQRRAHLQDQFMQLQPRMRQLPMGSPMGGAMGQpPYYGQGPQQQFNGQPLGWPRMSMMptpMGPGGPLRPNGLAPMNAV 443

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564329914  1012 VAKDRQLPTLMAQPPQTVVQvlAVKTTQQLPKLQQAPNQPKIYVQpqapQSQMALpTSSEKQPASQVEQ 1080
Cdd:TIGR01628  444 RAPSRNAQNAAQKPPMQPVM--YPPNYQSLPLSQDLPQPQSTASQ----GGQNKK-LAQVLASATPQMQ 505
 
Name Accession Description Interval E-value
ENT pfam03735
ENT domain; This presumed domain is named after Emsy N Terminus (ENT). Emsy is a protein that ...
 17-81 6.01e-28

ENT domain; This presumed domain is named after Emsy N Terminus (ENT). Emsy is a protein that is amplified in breast cancer and interacts with BRCA2. The N terminus of this protein is found to be similar to other vertebrate and plant proteins of unknown function. This domain has a completely conserved histidine residue that may be functionally important.


Pssm-ID: 461032  Cd Length: 71  Bit Score: 107.65  E-value: 6.01e-28
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564329914    17 KRILRKLELEAYAGVISALRAQGD-LTKEKKDLLGELSKVLSISTERHRAEVRRAVNDERLTTIAH 81
Cdd:pfam03735    1 KRQLRKLELEAYSSVLRAFRAQGDaLSWEKEKLLTELRKELNISDERHRAELRRVVNDERLKTIRE 66
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 936-1080 1.80e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 42.49  E-value: 1.80e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329914   936 KQQKLSQPQLEQTQLQVKTLQCFQTKQKQTIHLQ-ADQLQHKLTQMPQLSVRHQKLTPL---QQEQAQPKPDAQHTQHTV 1011
Cdd:TIGR01628  364 KEQRRAHLQDQFMQLQPRMRQLPMGSPMGGAMGQpPYYGQGPQQQFNGQPLGWPRMSMMptpMGPGGPLRPNGLAPMNAV 443

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564329914  1012 VAKDRQLPTLMAQPPQTVVQvlAVKTTQQLPKLQQAPNQPKIYVQpqapQSQMALpTSSEKQPASQVEQ 1080
Cdd:TIGR01628  444 RAPSRNAQNAAQKPPMQPVM--YPPNYQSLPLSQDLPQPQSTASQ----GGQNKK-LAQVLASATPQMQ 505
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 972-1149 5.82e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 41.22  E-value: 5.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329914  972 QLQHKLTQMPQLSVRHQKLTPlQQEQAQPKPDAQHTQHTVVAKDRQLPTLMAQPPQtvvQVLAVKTTQQLPKLQQAPNQP 1051
Cdd:PRK10263  754 QPQQPVAPQQQYQQPQQPVAP-QPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQ---QPVAPQPQYQQPQQPVAPQPQ 829

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329914 1052 kiYVQPQAPQSQmalptssekQPASQVEQPIITQgssvtkitfEGRQPPTVTKITGGSSVPKLTSPVTSISPIQASEKTA 1131
Cdd:PRK10263  830 --YQQPQQPVAP---------QPQDTLLHPLLMR---------NGDSRPLHKPTTPLPSLDLLTPPPSEVEPVDTFALEQ 889

                         170
                  ....*....|....*...
gi 564329914 1132 VSDILQMSLMEAQIDTNV 1149
Cdd:PRK10263  890 MARLVEARLADFRIKADV 907
 
Name Accession Description Interval E-value
ENT pfam03735
ENT domain; This presumed domain is named after Emsy N Terminus (ENT). Emsy is a protein that ...
 17-81 6.01e-28

ENT domain; This presumed domain is named after Emsy N Terminus (ENT). Emsy is a protein that is amplified in breast cancer and interacts with BRCA2. The N terminus of this protein is found to be similar to other vertebrate and plant proteins of unknown function. This domain has a completely conserved histidine residue that may be functionally important.


Pssm-ID: 461032  Cd Length: 71  Bit Score: 107.65  E-value: 6.01e-28
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564329914    17 KRILRKLELEAYAGVISALRAQGD-LTKEKKDLLGELSKVLSISTERHRAEVRRAVNDERLTTIAH 81
Cdd:pfam03735    1 KRQLRKLELEAYSSVLRAFRAQGDaLSWEKEKLLTELRKELNISDERHRAELRRVVNDERLKTIRE 66
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 936-1080 1.80e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 42.49  E-value: 1.80e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329914   936 KQQKLSQPQLEQTQLQVKTLQCFQTKQKQTIHLQ-ADQLQHKLTQMPQLSVRHQKLTPL---QQEQAQPKPDAQHTQHTV 1011
Cdd:TIGR01628  364 KEQRRAHLQDQFMQLQPRMRQLPMGSPMGGAMGQpPYYGQGPQQQFNGQPLGWPRMSMMptpMGPGGPLRPNGLAPMNAV 443

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564329914  1012 VAKDRQLPTLMAQPPQTVVQvlAVKTTQQLPKLQQAPNQPKIYVQpqapQSQMALpTSSEKQPASQVEQ 1080
Cdd:TIGR01628  444 RAPSRNAQNAAQKPPMQPVM--YPPNYQSLPLSQDLPQPQSTASQ----GGQNKK-LAQVLASATPQMQ 505
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 972-1149 5.82e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 41.22  E-value: 5.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329914  972 QLQHKLTQMPQLSVRHQKLTPlQQEQAQPKPDAQHTQHTVVAKDRQLPTLMAQPPQtvvQVLAVKTTQQLPKLQQAPNQP 1051
Cdd:PRK10263  754 QPQQPVAPQQQYQQPQQPVAP-QPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQ---QPVAPQPQYQQPQQPVAPQPQ 829

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329914 1052 kiYVQPQAPQSQmalptssekQPASQVEQPIITQgssvtkitfEGRQPPTVTKITGGSSVPKLTSPVTSISPIQASEKTA 1131
Cdd:PRK10263  830 --YQQPQQPVAP---------QPQDTLLHPLLMR---------NGDSRPLHKPTTPLPSLDLLTPPPSEVEPVDTFALEQ 889

                         170
                  ....*....|....*...
gi 564329914 1132 VSDILQMSLMEAQIDTNV 1149
Cdd:PRK10263  890 MARLVEARLADFRIKADV 907
PRK10927 PRK10927
cell division protein FtsN;
951-1095 7.48e-03

cell division protein FtsN;


Pssm-ID: 236797 [Multi-domain]  Cd Length: 319  Bit Score: 40.05  E-value: 7.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564329914  951 QVKTLQCFQTKQKQTI-HLQADQLQHKlTQMPQLSVRHQklTPLQQEQAQPKpDAQHTQHTVVAKDRQLPTLMAQPPQTv 1029
Cdd:PRK10927  107 EVKTPEQLTPEQRQLLeQMQADMRQQP-TQLVEVPWNEQ--TPEQRQQTLQR-QRQAQQLAEQQRLAQQSRTTEQSWQQ- 181

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564329914 1030 vqvlAVKTTQQLPKLQQaPNQPKIYVQPQAPQSQMALPTSSEKQPASQVEQPiITQGSSVTKITFE 1095
Cdd:PRK10927  182 ----QTRTSQAAPVQAQ-PRQSKPASTQQPYQDLLQTPAHTTAQSKPQQAAP-VTRAADAPKPTAE 241
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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