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Conserved domains on  [gi|564390237|ref|XP_006253595|]
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terminal uridylyltransferase 7 isoform X1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TUTase pfam19088
TUTase nucleotidyltransferase domain; This nucleotidyltransferase domain is found in TUTase ...
 194-411 2.27e-128

TUTase nucleotidyltransferase domain; This nucleotidyltransferase domain is found in TUTase enzymes. Terminal uridyltransferases (TUTases) execute 3' RNA uridylation across protists, fungi, metazoan and plant species.


:

Pssm-ID: 465974  Cd Length: 218  Bit Score: 397.58  E-value: 2.27e-128
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390237   194 EQDGELEGPVIDESVLSTKELLGLQQAEERLKRDCIERLKRRSRNCPTAKYTCKLCDALIDSIPFAHKHIKEKRHKKNLK 273
Cdd:pfam19088    1 DQDEDEDGPVIDESNLTAEQQLGLRQAEERLKRDYIHRLKKRSPEYPNFQYLCKLCSVHIENIQGAHKHIKEKRHKKNIM 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390237   274 EKQEEELLTTLPPPAPSQIHAVGSAIDRVVQEFGLHNENLDQRLEIKCAMENVFQHKLPDCSLRLYGSSCSRLGFRDSDV 353
Cdd:pfam19088   81 EKQEENELRALPPPSPAQLKALGAAVLEVAQEHGISDEDFEVRQEIVTRMEKIIQQHLPDCSLRLYGSCLTRFAFKTSDI 160

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 564390237   354 NIDVQFPAVMSQPDVLLLVQECLKNSDCFIDVDADFHARVPVVVCRHKQSGLLCKVSA 411
Cdd:pfam19088  161 NIDVQFPSTMTQPDVLIQVLEILKNSESYSDVESDFHAKVPVVFCRDKQSGLMCKVSA 218
TUTF7_u4 pfam16631
Unstructured region 4 on terminal uridylyltransferase 7; TUTF7_u4 is the fourth natively ...
 1370-1451 2.76e-42

Unstructured region 4 on terminal uridylyltransferase 7; TUTF7_u4 is the fourth natively unstructured region found on a set of higher eukaryote Terminal uridylyltransferase 7 proteins. The function is not known. The region is rich in arginine and lysine.


:

Pssm-ID: 465208  Cd Length: 88  Bit Score: 149.62  E-value: 2.76e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390237  1370 RRDQEDTPNQRYTESKEKRSKEDKEIQNKYTEKEVSAKEDKAAPCTAAKAKPMRAAVDLGREKLVRTPAEKWKRQDDRDS 1449
Cdd:pfam16631    7 RRDQEDTKNQRYPENKEKRSKEDKEIQNKYTEKEVSVKEGKLHPCTPQKAKPARAVVDTGREKSLRQSAEKWKRQDDRDL 86


                   ..
gi 564390237  1450 RE 1451
Cdd:pfam16631   87 RE 88
NT_PAP_TUTase cd05402
Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; ...
 1025-1142 6.82e-38

Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; Poly(A) polymerases (PAPs) catalyze mRNA poly(A) tail synthesis, and terminal uridylyl transferases (TUTases) uridylate RNA. PAPs in this subgroup include human PAP alpha, mouse testis-specific cytoplasmic PAP beta, human nuclear PAP gamma, Saccharomyces cerevisiae PAP1, TRF4 and-5, Schizosaccharomyces pombe caffeine-induced death proteins -1, and -14, Caenorhabditis elegans Germ Line Development-2, and Chlamydomonas reinhardtii MUT68. This family also includes human U6 snRNA-specific TUTase1, and Trypanosoma brucei 3'-TUTase-1,-2, and 4. This family belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, coordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. For the majority of proteins in this family, these carboxylate residues are conserved.


:

Pssm-ID: 143392 [Multi-domain]  Cd Length: 114  Bit Score: 138.07  E-value: 6.82e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390237 1025 AREHIRQNLESFIKQDFPGTKLSLFGSSKNGFGFKQSDLDVCMTINGHEtaegLDCVRTIEELARVLRKHSGLRNILPIT 1104
Cdd:cd05402     1 KREEVLDRLQELIKEWFPGAKLYPFGSYVTGLGLPGSDIDLCLLGPNHR----VDREDFLRKLAKLLKKSGEVVEVEPII 76

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 564390237 1105 TAKVPIVKFSHLRSGLEVDISLYNTLALHNTRLLFAYS 1142
Cdd:cd05402    77 NARVPIIKFVDKPTGIEVDISFNNLNGIRNTKLLRAYV 114
TRF4 super family cl34961
DNA polymerase sigma [Replication, recombination and repair];
983-1314 1.30e-37

DNA polymerase sigma [Replication, recombination and repair];


The actual alignment was detected with superfamily member COG5260:

Pssm-ID: 227585 [Multi-domain]  Cd Length: 482  Bit Score: 148.77  E-value: 1.30e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390237  983 PEDFKRIQLEPLPPLTPK-----FSNILDQVCIQCYKDFSPTIVEDQAREHIRQNLESFIKQDFPGTKLSLFGSSKNGFG 1057
Cdd:COG5260    30 PLDAKKVSIQELLELSIDsvfneESDELTSELLEFYDYIAPSDEELKRRKALLEKLRTLLKKEFPDADLKVFGSTETGLA 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390237 1058 FKQSDLDVCMTINGHEtaeGLDCVRTIEELARVLRKHSGLRNILpITTAKVPIVKFSHLRSGLEVDISLYNTLALHNTRL 1137
Cdd:COG5260   110 LPKSDIDLCIISDPRG---YKETRNAGSLASHLFKKNLAKEVVV-VSTARVPIIKLVDPQSGLHCDISFNNTNGIVNAKL 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390237 1138 LFAYSAIDPRVKYLCYTMKVFTKMCDIGDASRGSLSSYAYTLMVLYFLQQRSPPviPVLQEIYKGEKKpeilvdgwniyf 1217
Cdd:COG5260   186 IRSYLKEDPRLRPLVLIIKHWLKRRALNDVATGTLSSYTISCMVLSFLQMHPPF--LFFDNGLLSPLK------------ 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390237 1218 fdqinelptcwpeYGKNTESVGQLWLGLLRFYTEEFDFKEHVISIRR-KSLLTTFKKQW----TSKYIVIEDPF-DLNHN 1291
Cdd:COG5260   252 -------------YNKNIDNLGVLFDDFFELYGKSFNYSLVVLSINSgDFYLPKYEKGWlkpsKPNSLSIQDPGtDRNND 318

                         330       340
                  ....*....|....*....|...
gi 564390237 1292 LGAGlSRKMtNFIMKAFINGRRV 1314
Cdd:COG5260   319 ISAV-SFNI-KDIKAAFIRAFEL 339
PAP_assoc pfam03828
Cid1 family poly A polymerase; This domain is found in poly(A) polymerases and has been shown ...
 550-599 2.74e-12

Cid1 family poly A polymerase; This domain is found in poly(A) polymerases and has been shown to have polynucleotide adenylyltransferase activity. Proteins in this family have been located to both the nucleus and the cytoplasm.


:

Pssm-ID: 427532  Cd Length: 60  Bit Score: 62.98  E-value: 2.74e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 564390237   550 PVGQLWVELLRFYALEFNLADLVISIRVKELISRESKDWPK------KRIAIEDPY 599
Cdd:pfam03828    1 SLGELLIGFFEYYGREFDYENVVISIRTGGILSKKEKGWLRnegrrpFLLCIEDPF 56
ZnF_C2HC smart00343
zinc finger;
1453-1469 2.43e-03

zinc finger;


:

Pssm-ID: 197667 [Multi-domain]  Cd Length: 17  Bit Score: 36.65  E-value: 2.43e-03
                            10
                    ....*....|....*..
gi 564390237   1453 RCFICGREGHIKKECPQ 1469
Cdd:smart00343    1 KCYNCGKEGHIARDCPS 17
ZnF_C2HC smart00343
zinc finger;
1347-1362 5.93e-03

zinc finger;


:

Pssm-ID: 197667 [Multi-domain]  Cd Length: 17  Bit Score: 35.50  E-value: 5.93e-03
                            10
                    ....*....|....*.
gi 564390237   1347 CCRICGKIGHFMKDCP 1362
Cdd:smart00343    1 KCYNCGKEGHIARDCP 16
 
Name Accession Description Interval E-value
TUTase pfam19088
TUTase nucleotidyltransferase domain; This nucleotidyltransferase domain is found in TUTase ...
 194-411 2.27e-128

TUTase nucleotidyltransferase domain; This nucleotidyltransferase domain is found in TUTase enzymes. Terminal uridyltransferases (TUTases) execute 3' RNA uridylation across protists, fungi, metazoan and plant species.


Pssm-ID: 465974  Cd Length: 218  Bit Score: 397.58  E-value: 2.27e-128
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390237   194 EQDGELEGPVIDESVLSTKELLGLQQAEERLKRDCIERLKRRSRNCPTAKYTCKLCDALIDSIPFAHKHIKEKRHKKNLK 273
Cdd:pfam19088    1 DQDEDEDGPVIDESNLTAEQQLGLRQAEERLKRDYIHRLKKRSPEYPNFQYLCKLCSVHIENIQGAHKHIKEKRHKKNIM 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390237   274 EKQEEELLTTLPPPAPSQIHAVGSAIDRVVQEFGLHNENLDQRLEIKCAMENVFQHKLPDCSLRLYGSSCSRLGFRDSDV 353
Cdd:pfam19088   81 EKQEENELRALPPPSPAQLKALGAAVLEVAQEHGISDEDFEVRQEIVTRMEKIIQQHLPDCSLRLYGSCLTRFAFKTSDI 160

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 564390237   354 NIDVQFPAVMSQPDVLLLVQECLKNSDCFIDVDADFHARVPVVVCRHKQSGLLCKVSA 411
Cdd:pfam19088  161 NIDVQFPSTMTQPDVLIQVLEILKNSESYSDVESDFHAKVPVVFCRDKQSGLMCKVSA 218
TUTF7_u4 pfam16631
Unstructured region 4 on terminal uridylyltransferase 7; TUTF7_u4 is the fourth natively ...
 1370-1451 2.76e-42

Unstructured region 4 on terminal uridylyltransferase 7; TUTF7_u4 is the fourth natively unstructured region found on a set of higher eukaryote Terminal uridylyltransferase 7 proteins. The function is not known. The region is rich in arginine and lysine.


Pssm-ID: 465208  Cd Length: 88  Bit Score: 149.62  E-value: 2.76e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390237  1370 RRDQEDTPNQRYTESKEKRSKEDKEIQNKYTEKEVSAKEDKAAPCTAAKAKPMRAAVDLGREKLVRTPAEKWKRQDDRDS 1449
Cdd:pfam16631    7 RRDQEDTKNQRYPENKEKRSKEDKEIQNKYTEKEVSVKEGKLHPCTPQKAKPARAVVDTGREKSLRQSAEKWKRQDDRDL 86


                   ..
gi 564390237  1450 RE 1451
Cdd:pfam16631   87 RE 88
NT_PAP_TUTase cd05402
Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; ...
 1025-1142 6.82e-38

Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; Poly(A) polymerases (PAPs) catalyze mRNA poly(A) tail synthesis, and terminal uridylyl transferases (TUTases) uridylate RNA. PAPs in this subgroup include human PAP alpha, mouse testis-specific cytoplasmic PAP beta, human nuclear PAP gamma, Saccharomyces cerevisiae PAP1, TRF4 and-5, Schizosaccharomyces pombe caffeine-induced death proteins -1, and -14, Caenorhabditis elegans Germ Line Development-2, and Chlamydomonas reinhardtii MUT68. This family also includes human U6 snRNA-specific TUTase1, and Trypanosoma brucei 3'-TUTase-1,-2, and 4. This family belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, coordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. For the majority of proteins in this family, these carboxylate residues are conserved.


Pssm-ID: 143392 [Multi-domain]  Cd Length: 114  Bit Score: 138.07  E-value: 6.82e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390237 1025 AREHIRQNLESFIKQDFPGTKLSLFGSSKNGFGFKQSDLDVCMTINGHEtaegLDCVRTIEELARVLRKHSGLRNILPIT 1104
Cdd:cd05402     1 KREEVLDRLQELIKEWFPGAKLYPFGSYVTGLGLPGSDIDLCLLGPNHR----VDREDFLRKLAKLLKKSGEVVEVEPII 76

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 564390237 1105 TAKVPIVKFSHLRSGLEVDISLYNTLALHNTRLLFAYS 1142
Cdd:cd05402    77 NARVPIIKFVDKPTGIEVDISFNNLNGIRNTKLLRAYV 114
TRF4 COG5260
DNA polymerase sigma [Replication, recombination and repair];
983-1314 1.30e-37

DNA polymerase sigma [Replication, recombination and repair];


Pssm-ID: 227585 [Multi-domain]  Cd Length: 482  Bit Score: 148.77  E-value: 1.30e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390237  983 PEDFKRIQLEPLPPLTPK-----FSNILDQVCIQCYKDFSPTIVEDQAREHIRQNLESFIKQDFPGTKLSLFGSSKNGFG 1057
Cdd:COG5260    30 PLDAKKVSIQELLELSIDsvfneESDELTSELLEFYDYIAPSDEELKRRKALLEKLRTLLKKEFPDADLKVFGSTETGLA 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390237 1058 FKQSDLDVCMTINGHEtaeGLDCVRTIEELARVLRKHSGLRNILpITTAKVPIVKFSHLRSGLEVDISLYNTLALHNTRL 1137
Cdd:COG5260   110 LPKSDIDLCIISDPRG---YKETRNAGSLASHLFKKNLAKEVVV-VSTARVPIIKLVDPQSGLHCDISFNNTNGIVNAKL 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390237 1138 LFAYSAIDPRVKYLCYTMKVFTKMCDIGDASRGSLSSYAYTLMVLYFLQQRSPPviPVLQEIYKGEKKpeilvdgwniyf 1217
Cdd:COG5260   186 IRSYLKEDPRLRPLVLIIKHWLKRRALNDVATGTLSSYTISCMVLSFLQMHPPF--LFFDNGLLSPLK------------ 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390237 1218 fdqinelptcwpeYGKNTESVGQLWLGLLRFYTEEFDFKEHVISIRR-KSLLTTFKKQW----TSKYIVIEDPF-DLNHN 1291
Cdd:COG5260   252 -------------YNKNIDNLGVLFDDFFELYGKSFNYSLVVLSINSgDFYLPKYEKGWlkpsKPNSLSIQDPGtDRNND 318

                         330       340
                  ....*....|....*....|...
gi 564390237 1292 LGAGlSRKMtNFIMKAFINGRRV 1314
Cdd:COG5260   319 ISAV-SFNI-KDIKAAFIRAFEL 339
NT_PAP_TUTase cd05402
Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; ...
 315-427 6.20e-28

Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; Poly(A) polymerases (PAPs) catalyze mRNA poly(A) tail synthesis, and terminal uridylyl transferases (TUTases) uridylate RNA. PAPs in this subgroup include human PAP alpha, mouse testis-specific cytoplasmic PAP beta, human nuclear PAP gamma, Saccharomyces cerevisiae PAP1, TRF4 and-5, Schizosaccharomyces pombe caffeine-induced death proteins -1, and -14, Caenorhabditis elegans Germ Line Development-2, and Chlamydomonas reinhardtii MUT68. This family also includes human U6 snRNA-specific TUTase1, and Trypanosoma brucei 3'-TUTase-1,-2, and 4. This family belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, coordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. For the majority of proteins in this family, these carboxylate residues are conserved.


Pssm-ID: 143392 [Multi-domain]  Cd Length: 114  Bit Score: 109.57  E-value: 6.20e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390237  315 QRLEIKCAMENVFQHKLPDCSLRLYGSSCSRLGFRDSDVNIDVQFPA-VMSQPDVLLLVQECLKNSDCFIDVDADFHARV 393
Cdd:cd05402     1 KREEVLDRLQELIKEWFPGAKLYPFGSYVTGLGLPGSDIDLCLLGPNhRVDREDFLRKLAKLLKKSGEVVEVEPIINARV 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 564390237  394 PVVVCRHKQSGLLCKVSAGNENAWLTTKHLTALG 427
Cdd:cd05402    81 PIIKFVDKPTGIEVDISFNNLNGIRNTKLLRAYV 114
TRF4 COG5260
DNA polymerase sigma [Replication, recombination and repair];
251-478 6.75e-18

DNA polymerase sigma [Replication, recombination and repair];


Pssm-ID: 227585 [Multi-domain]  Cd Length: 482  Bit Score: 88.68  E-value: 6.75e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390237  251 ALIDSIPFAHKHIKEKRHKkNLKEKQEEELLTTLPPPAPSQIHAVGSAIDR--------VVQEFGLHNENLDQRLEIKCA 322
Cdd:COG5260     6 KLFISLNSSSEEEFETIME-QKERRPLDAKKVSIQELLELSIDSVFNEESDeltselleFYDYIAPSDEELKRRKALLEK 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390237  323 MENVFQHKLPDCSLRLYGSSCSRLGFRDSDVNIDVQFPAVMSQPDV-LLLVQECLKNSDCFIDVDADFHARVPVVVCRHK 401
Cdd:COG5260    85 LRTLLKKEFPDADLKVFGSTETGLALPKSDIDLCIISDPRGYKETRnAGSLASHLFKKNLAKEVVVVSTARVPIIKLVDP 164

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564390237  402 QSGLLCKVSAGNENAWLTTKHLTALGKLEPRLLPLVIAFRYWAKLCSIDRPEEGGLPPYVFALMAVFFLQQRKEPLL 478
Cdd:COG5260   165 QSGLHCDISFNNTNGIVNAKLIRSYLKEDPRLRPLVLIIKHWLKRRALNDVATGTLSSYTISCMVLSFLQMHPPFLF 241
PAP_assoc pfam03828
Cid1 family poly A polymerase; This domain is found in poly(A) polymerases and has been shown ...
 1237-1290 3.46e-15

Cid1 family poly A polymerase; This domain is found in poly(A) polymerases and has been shown to have polynucleotide adenylyltransferase activity. Proteins in this family have been located to both the nucleus and the cytoplasm.


Pssm-ID: 427532  Cd Length: 60  Bit Score: 71.06  E-value: 3.46e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390237  1237 SVGQLWLGLLRFYTEEFDFKEHVISIRRKSLLTTFKKQWT------SKYIVIEDPFDLNH 1290
Cdd:pfam03828    1 SLGELLIGFFEYYGREFDYENVVISIRTGGILSKKEKGWLrnegrrPFLLCIEDPFDLDN 60
PAP_assoc pfam03828
Cid1 family poly A polymerase; This domain is found in poly(A) polymerases and has been shown ...
 550-599 2.74e-12

Cid1 family poly A polymerase; This domain is found in poly(A) polymerases and has been shown to have polynucleotide adenylyltransferase activity. Proteins in this family have been located to both the nucleus and the cytoplasm.


Pssm-ID: 427532  Cd Length: 60  Bit Score: 62.98  E-value: 2.74e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 564390237   550 PVGQLWVELLRFYALEFNLADLVISIRVKELISRESKDWPK------KRIAIEDPY 599
Cdd:pfam03828    1 SLGELLIGFFEYYGREFDYENVVISIRTGGILSKKEKGWLRnegrrpFLLCIEDPF 56
NTP_transf_2 pfam01909
Nucleotidyltransferase domain; Members of this family belong to a large family of ...
 1033-1103 1.43e-05

Nucleotidyltransferase domain; Members of this family belong to a large family of nucleotidyltransferases. This family includes kanamycin nucleotidyltransferase (KNTase) which is a plasmid-coded enzyme responsible for some types of bacterial resistance to aminoglycosides. KNTase in-activates antibiotics by catalysing the addition of a nucleotidyl group onto the drug.


Pssm-ID: 396474  Cd Length: 91  Bit Score: 45.10  E-value: 1.43e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564390237  1033 LESFIKQDFPGTKLSLFGSSKNGFGFKQSDLDVCMTINGH-ETAEGLDCVRTIEELARVLRKHSGLRNILPI 1103
Cdd:pfam01909    4 LREILKELFPVAEVVLFGSYARGTALPGSDIDLLVVFPEPvEEERLLKLAKIIKELEELLGLEVDLVTREKI 75
ZnF_C2HC smart00343
zinc finger;
1453-1469 2.43e-03

zinc finger;


Pssm-ID: 197667 [Multi-domain]  Cd Length: 17  Bit Score: 36.65  E-value: 2.43e-03
                            10
                    ....*....|....*..
gi 564390237   1453 RCFICGREGHIKKECPQ 1469
Cdd:smart00343    1 KCYNCGKEGHIARDCPS 17
zf-CCHC pfam00098
Zinc knuckle; The zinc knuckle is a zinc binding motif composed of the the following ...
 1452-1469 3.32e-03

Zinc knuckle; The zinc knuckle is a zinc binding motif composed of the the following CX2CX4HX4C where X can be any amino acid. The motifs are mostly from retroviral gag proteins (nucleocapsid). Prototype structure is from HIV. Also contains members involved in eukaryotic gene regulation, such as C. elegans GLH-1. Structure is an 18-residue zinc finger.


Pssm-ID: 395050 [Multi-domain]  Cd Length: 18  Bit Score: 36.35  E-value: 3.32e-03
                           10
                   ....*....|....*...
gi 564390237  1452 KRCFICGREGHIKKECPQ 1469
Cdd:pfam00098    1 GKCYNCGEPGHIARDCPK 18
ZnF_C2HC smart00343
zinc finger;
1347-1362 5.93e-03

zinc finger;


Pssm-ID: 197667 [Multi-domain]  Cd Length: 17  Bit Score: 35.50  E-value: 5.93e-03
                            10
                    ....*....|....*.
gi 564390237   1347 CCRICGKIGHFMKDCP 1362
Cdd:smart00343    1 KCYNCGKEGHIARDCP 16
 
Name Accession Description Interval E-value
TUTase pfam19088
TUTase nucleotidyltransferase domain; This nucleotidyltransferase domain is found in TUTase ...
 194-411 2.27e-128

TUTase nucleotidyltransferase domain; This nucleotidyltransferase domain is found in TUTase enzymes. Terminal uridyltransferases (TUTases) execute 3' RNA uridylation across protists, fungi, metazoan and plant species.


Pssm-ID: 465974  Cd Length: 218  Bit Score: 397.58  E-value: 2.27e-128
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390237   194 EQDGELEGPVIDESVLSTKELLGLQQAEERLKRDCIERLKRRSRNCPTAKYTCKLCDALIDSIPFAHKHIKEKRHKKNLK 273
Cdd:pfam19088    1 DQDEDEDGPVIDESNLTAEQQLGLRQAEERLKRDYIHRLKKRSPEYPNFQYLCKLCSVHIENIQGAHKHIKEKRHKKNIM 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390237   274 EKQEEELLTTLPPPAPSQIHAVGSAIDRVVQEFGLHNENLDQRLEIKCAMENVFQHKLPDCSLRLYGSSCSRLGFRDSDV 353
Cdd:pfam19088   81 EKQEENELRALPPPSPAQLKALGAAVLEVAQEHGISDEDFEVRQEIVTRMEKIIQQHLPDCSLRLYGSCLTRFAFKTSDI 160

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 564390237   354 NIDVQFPAVMSQPDVLLLVQECLKNSDCFIDVDADFHARVPVVVCRHKQSGLLCKVSA 411
Cdd:pfam19088  161 NIDVQFPSTMTQPDVLIQVLEILKNSESYSDVESDFHAKVPVVFCRDKQSGLMCKVSA 218
TUTF7_u4 pfam16631
Unstructured region 4 on terminal uridylyltransferase 7; TUTF7_u4 is the fourth natively ...
 1370-1451 2.76e-42

Unstructured region 4 on terminal uridylyltransferase 7; TUTF7_u4 is the fourth natively unstructured region found on a set of higher eukaryote Terminal uridylyltransferase 7 proteins. The function is not known. The region is rich in arginine and lysine.


Pssm-ID: 465208  Cd Length: 88  Bit Score: 149.62  E-value: 2.76e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390237  1370 RRDQEDTPNQRYTESKEKRSKEDKEIQNKYTEKEVSAKEDKAAPCTAAKAKPMRAAVDLGREKLVRTPAEKWKRQDDRDS 1449
Cdd:pfam16631    7 RRDQEDTKNQRYPENKEKRSKEDKEIQNKYTEKEVSVKEGKLHPCTPQKAKPARAVVDTGREKSLRQSAEKWKRQDDRDL 86


                   ..
gi 564390237  1450 RE 1451
Cdd:pfam16631   87 RE 88
NT_PAP_TUTase cd05402
Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; ...
 1025-1142 6.82e-38

Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; Poly(A) polymerases (PAPs) catalyze mRNA poly(A) tail synthesis, and terminal uridylyl transferases (TUTases) uridylate RNA. PAPs in this subgroup include human PAP alpha, mouse testis-specific cytoplasmic PAP beta, human nuclear PAP gamma, Saccharomyces cerevisiae PAP1, TRF4 and-5, Schizosaccharomyces pombe caffeine-induced death proteins -1, and -14, Caenorhabditis elegans Germ Line Development-2, and Chlamydomonas reinhardtii MUT68. This family also includes human U6 snRNA-specific TUTase1, and Trypanosoma brucei 3'-TUTase-1,-2, and 4. This family belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, coordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. For the majority of proteins in this family, these carboxylate residues are conserved.


Pssm-ID: 143392 [Multi-domain]  Cd Length: 114  Bit Score: 138.07  E-value: 6.82e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390237 1025 AREHIRQNLESFIKQDFPGTKLSLFGSSKNGFGFKQSDLDVCMTINGHEtaegLDCVRTIEELARVLRKHSGLRNILPIT 1104
Cdd:cd05402     1 KREEVLDRLQELIKEWFPGAKLYPFGSYVTGLGLPGSDIDLCLLGPNHR----VDREDFLRKLAKLLKKSGEVVEVEPII 76

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 564390237 1105 TAKVPIVKFSHLRSGLEVDISLYNTLALHNTRLLFAYS 1142
Cdd:cd05402    77 NARVPIIKFVDKPTGIEVDISFNNLNGIRNTKLLRAYV 114
TRF4 COG5260
DNA polymerase sigma [Replication, recombination and repair];
983-1314 1.30e-37

DNA polymerase sigma [Replication, recombination and repair];


Pssm-ID: 227585 [Multi-domain]  Cd Length: 482  Bit Score: 148.77  E-value: 1.30e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390237  983 PEDFKRIQLEPLPPLTPK-----FSNILDQVCIQCYKDFSPTIVEDQAREHIRQNLESFIKQDFPGTKLSLFGSSKNGFG 1057
Cdd:COG5260    30 PLDAKKVSIQELLELSIDsvfneESDELTSELLEFYDYIAPSDEELKRRKALLEKLRTLLKKEFPDADLKVFGSTETGLA 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390237 1058 FKQSDLDVCMTINGHEtaeGLDCVRTIEELARVLRKHSGLRNILpITTAKVPIVKFSHLRSGLEVDISLYNTLALHNTRL 1137
Cdd:COG5260   110 LPKSDIDLCIISDPRG---YKETRNAGSLASHLFKKNLAKEVVV-VSTARVPIIKLVDPQSGLHCDISFNNTNGIVNAKL 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390237 1138 LFAYSAIDPRVKYLCYTMKVFTKMCDIGDASRGSLSSYAYTLMVLYFLQQRSPPviPVLQEIYKGEKKpeilvdgwniyf 1217
Cdd:COG5260   186 IRSYLKEDPRLRPLVLIIKHWLKRRALNDVATGTLSSYTISCMVLSFLQMHPPF--LFFDNGLLSPLK------------ 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390237 1218 fdqinelptcwpeYGKNTESVGQLWLGLLRFYTEEFDFKEHVISIRR-KSLLTTFKKQW----TSKYIVIEDPF-DLNHN 1291
Cdd:COG5260   252 -------------YNKNIDNLGVLFDDFFELYGKSFNYSLVVLSINSgDFYLPKYEKGWlkpsKPNSLSIQDPGtDRNND 318

                         330       340
                  ....*....|....*....|...
gi 564390237 1292 LGAGlSRKMtNFIMKAFINGRRV 1314
Cdd:COG5260   319 ISAV-SFNI-KDIKAAFIRAFEL 339
NT_PAP_TUTase cd05402
Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; ...
 315-427 6.20e-28

Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; Poly(A) polymerases (PAPs) catalyze mRNA poly(A) tail synthesis, and terminal uridylyl transferases (TUTases) uridylate RNA. PAPs in this subgroup include human PAP alpha, mouse testis-specific cytoplasmic PAP beta, human nuclear PAP gamma, Saccharomyces cerevisiae PAP1, TRF4 and-5, Schizosaccharomyces pombe caffeine-induced death proteins -1, and -14, Caenorhabditis elegans Germ Line Development-2, and Chlamydomonas reinhardtii MUT68. This family also includes human U6 snRNA-specific TUTase1, and Trypanosoma brucei 3'-TUTase-1,-2, and 4. This family belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, coordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. For the majority of proteins in this family, these carboxylate residues are conserved.


Pssm-ID: 143392 [Multi-domain]  Cd Length: 114  Bit Score: 109.57  E-value: 6.20e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390237  315 QRLEIKCAMENVFQHKLPDCSLRLYGSSCSRLGFRDSDVNIDVQFPA-VMSQPDVLLLVQECLKNSDCFIDVDADFHARV 393
Cdd:cd05402     1 KREEVLDRLQELIKEWFPGAKLYPFGSYVTGLGLPGSDIDLCLLGPNhRVDREDFLRKLAKLLKKSGEVVEVEPIINARV 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 564390237  394 PVVVCRHKQSGLLCKVSAGNENAWLTTKHLTALG 427
Cdd:cd05402    81 PIIKFVDKPTGIEVDISFNNLNGIRNTKLLRAYV 114
TRF4 COG5260
DNA polymerase sigma [Replication, recombination and repair];
251-478 6.75e-18

DNA polymerase sigma [Replication, recombination and repair];


Pssm-ID: 227585 [Multi-domain]  Cd Length: 482  Bit Score: 88.68  E-value: 6.75e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390237  251 ALIDSIPFAHKHIKEKRHKkNLKEKQEEELLTTLPPPAPSQIHAVGSAIDR--------VVQEFGLHNENLDQRLEIKCA 322
Cdd:COG5260     6 KLFISLNSSSEEEFETIME-QKERRPLDAKKVSIQELLELSIDSVFNEESDeltselleFYDYIAPSDEELKRRKALLEK 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390237  323 MENVFQHKLPDCSLRLYGSSCSRLGFRDSDVNIDVQFPAVMSQPDV-LLLVQECLKNSDCFIDVDADFHARVPVVVCRHK 401
Cdd:COG5260    85 LRTLLKKEFPDADLKVFGSTETGLALPKSDIDLCIISDPRGYKETRnAGSLASHLFKKNLAKEVVVVSTARVPIIKLVDP 164

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564390237  402 QSGLLCKVSAGNENAWLTTKHLTALGKLEPRLLPLVIAFRYWAKLCSIDRPEEGGLPPYVFALMAVFFLQQRKEPLL 478
Cdd:COG5260   165 QSGLHCDISFNNTNGIVNAKLIRSYLKEDPRLRPLVLIIKHWLKRRALNDVATGTLSSYTISCMVLSFLQMHPPFLF 241
PAP_assoc pfam03828
Cid1 family poly A polymerase; This domain is found in poly(A) polymerases and has been shown ...
 1237-1290 3.46e-15

Cid1 family poly A polymerase; This domain is found in poly(A) polymerases and has been shown to have polynucleotide adenylyltransferase activity. Proteins in this family have been located to both the nucleus and the cytoplasm.


Pssm-ID: 427532  Cd Length: 60  Bit Score: 71.06  E-value: 3.46e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390237  1237 SVGQLWLGLLRFYTEEFDFKEHVISIRRKSLLTTFKKQWT------SKYIVIEDPFDLNH 1290
Cdd:pfam03828    1 SLGELLIGFFEYYGREFDYENVVISIRTGGILSKKEKGWLrnegrrPFLLCIEDPFDLDN 60
PAP_assoc pfam03828
Cid1 family poly A polymerase; This domain is found in poly(A) polymerases and has been shown ...
 550-599 2.74e-12

Cid1 family poly A polymerase; This domain is found in poly(A) polymerases and has been shown to have polynucleotide adenylyltransferase activity. Proteins in this family have been located to both the nucleus and the cytoplasm.


Pssm-ID: 427532  Cd Length: 60  Bit Score: 62.98  E-value: 2.74e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 564390237   550 PVGQLWVELLRFYALEFNLADLVISIRVKELISRESKDWPK------KRIAIEDPY 599
Cdd:pfam03828    1 SLGELLIGFFEYYGREFDYENVVISIRTGGILSKKEKGWLRnegrrpFLLCIEDPF 56
NTP_transf_2 pfam01909
Nucleotidyltransferase domain; Members of this family belong to a large family of ...
 1033-1103 1.43e-05

Nucleotidyltransferase domain; Members of this family belong to a large family of nucleotidyltransferases. This family includes kanamycin nucleotidyltransferase (KNTase) which is a plasmid-coded enzyme responsible for some types of bacterial resistance to aminoglycosides. KNTase in-activates antibiotics by catalysing the addition of a nucleotidyl group onto the drug.


Pssm-ID: 396474  Cd Length: 91  Bit Score: 45.10  E-value: 1.43e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564390237  1033 LESFIKQDFPGTKLSLFGSSKNGFGFKQSDLDVCMTINGH-ETAEGLDCVRTIEELARVLRKHSGLRNILPI 1103
Cdd:pfam01909    4 LREILKELFPVAEVVLFGSYARGTALPGSDIDLLVVFPEPvEEERLLKLAKIIKELEELLGLEVDLVTREKI 75
TUTase pfam19088
TUTase nucleotidyltransferase domain; This nucleotidyltransferase domain is found in TUTase ...
 968-1125 1.60e-04

TUTase nucleotidyltransferase domain; This nucleotidyltransferase domain is found in TUTase enzymes. Terminal uridyltransferases (TUTases) execute 3' RNA uridylation across protists, fungi, metazoan and plant species.


Pssm-ID: 465974  Cd Length: 218  Bit Score: 44.74  E-value: 1.60e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390237   968 VCSLC--------------KREGHlKKDCPEDFKRIQLEPLPPLTPKFSNILDQVCIQCYKDFSPTIVEDQAREHIRQNL 1033
Cdd:pfam19088   52 LCKLCsvhieniqgahkhiKEKRH-KKNIMEKQEENELRALPPPSPAQLKALGAAVLEVAQEHGISDEDFEVRQEIVTRM 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564390237  1034 ESFIKQDFPGTKLSLFGSSKNGFGFKQSDLDVCMTINGHETAEglDCVRTIEElarVLRKHSGLRNILPITTAKVPIVKF 1113
Cdd:pfam19088  131 EKIIQQHLPDCSLRLYGSCLTRFAFKTSDINIDVQFPSTMTQP--DVLIQVLE---ILKNSESYSDVESDFHAKVPVVFC 205

                          170
                   ....*....|..
gi 564390237  1114 SHLRSGLEVDIS 1125
Cdd:pfam19088  206 RDKQSGLMCKVS 217
ZnF_C2HC smart00343
zinc finger;
1453-1469 2.43e-03

zinc finger;


Pssm-ID: 197667 [Multi-domain]  Cd Length: 17  Bit Score: 36.65  E-value: 2.43e-03
                            10
                    ....*....|....*..
gi 564390237   1453 RCFICGREGHIKKECPQ 1469
Cdd:smart00343    1 KCYNCGKEGHIARDCPS 17
zf-CCHC pfam00098
Zinc knuckle; The zinc knuckle is a zinc binding motif composed of the the following ...
 1452-1469 3.32e-03

Zinc knuckle; The zinc knuckle is a zinc binding motif composed of the the following CX2CX4HX4C where X can be any amino acid. The motifs are mostly from retroviral gag proteins (nucleocapsid). Prototype structure is from HIV. Also contains members involved in eukaryotic gene regulation, such as C. elegans GLH-1. Structure is an 18-residue zinc finger.


Pssm-ID: 395050 [Multi-domain]  Cd Length: 18  Bit Score: 36.35  E-value: 3.32e-03
                           10
                   ....*....|....*...
gi 564390237  1452 KRCFICGREGHIKKECPQ 1469
Cdd:pfam00098    1 GKCYNCGEPGHIARDCPK 18
ZnF_C2HC smart00343
zinc finger;
1347-1362 5.93e-03

zinc finger;


Pssm-ID: 197667 [Multi-domain]  Cd Length: 17  Bit Score: 35.50  E-value: 5.93e-03
                            10
                    ....*....|....*.
gi 564390237   1347 CCRICGKIGHFMKDCP 1362
Cdd:smart00343    1 KCYNCGKEGHIARDCP 16
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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