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Conserved domains on  [gi|564392095|ref|XP_006254274|]
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scm-like with four MBT domains protein 2 isoform X1 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MBT_SFMBT2_rpt1 cd20112
first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 ...
70-163 1.34e-68

first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.


:

Pssm-ID: 439102  Cd Length: 94  Bit Score: 222.17  E-value: 1.34e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095  70 QSNFQPGMKLEVANKNHPDTYWVATIITTCGQLLLLRYCGYGEDRRADFWCDVIIADLHPVGWCTQNNKVLRPPDAIKEK 149
Cdd:cd20112    1 QSSFQPGMKLEVANKSNPDTYWVATIITTCGQLLLLRYCGYGDDRRADFWCDVMTADLHPVGWCTQNNKVLMPPDAIKEK 80
                         90
                 ....*....|....
gi 564392095 150 YADWEEFLIHELTG 163
Cdd:cd20112   81 YTDWTEFLIHDLTG 94
MBT_SFMBT2_rpt3 cd20116
three malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 ...
297-389 7.23e-57

three malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


:

Pssm-ID: 439106  Cd Length: 93  Bit Score: 190.01  E-value: 7.23e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095 297 HFFTVGMRLETLHINDPFHIYPATVTKVFNSQFFQVAIDDLRAETNGLTMLCHADSLGILPVQWCLKNGVNLAPPKGYSG 376
Cdd:cd20116    1 HSFTVGMKLEVVDPREPFHICPASVTKVFNNHYFQVTVDDLRPEASENSMLCHADSLGILPVQWCLKNGVNLTPPKGYSG 80
                         90
                 ....*....|...
gi 564392095 377 QDFNWVDYHKQRE 389
Cdd:cd20116   81 QDFDWADYQKQCG 93
MBT super family cl45897
malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes ...
182-269 1.41e-50

malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes methylated lysine residues on histones and are thought to affect a variety of chromatin processes, including transcription. It exists as tandem repeats and is found in a number of nuclear proteins such as Drosophila sex comb on midleg protein. In the human genome, there are at least 9 MBT repeat proteins, each containing two, three or four MBT repeats. MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine (monomethyllysine and/or dimethyllysine).


The actual alignment was detected with superfamily member cd20114:

Pssm-ID: 459242  Cd Length: 98  Bit Score: 172.60  E-value: 1.41e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095 182 IDLITVDSLIELQDSQNPFQYWIVSVIENVGGRLRLRYVGLEHtESYDRWLFYLDYRLRPIGWCQEKKYRMDPPSELYYL 261
Cdd:cd20114    1 VDLITVGSLIELQDSQNPFQYWIVRVIENVGGRLRLRYVGLED-ESHDQWLFYLDTRLRPVGWCQENNLRMEPPTEICDL 79

                 ....*...
gi 564392095 262 KLPFEWKC 269
Cdd:cd20114   80 KSASEWKE 87
SAM_Scm-like-4MBT1,2 cd09581
SAM domain of Scm-like-4MBT1,2 proteins of Polycomb group; SAM (sterile alpha motif) domain of ...
807-890 7.05e-50

SAM domain of Scm-like-4MBT1,2 proteins of Polycomb group; SAM (sterile alpha motif) domain of Scm-like-4MBT1,2 (Sex comb on midleg, Malignant Brain Tumor) subfamily proteins (also known as Sfmbt1,2 proteins) is a putative protein-protein interaction domain. Proteins of this subfamily are transcriptional regulators belonging to Polycomb group. The majority of them are multidomain proteins: in addition to the C-terminal SAM domain, they contain four MBT repeats and DUF5388 domain. The MBT repeats of the human sfmbt1 protein are responsible for association with the nuclear matrix and for selective binding of H3 histone N-terminal tails, while the exact function of the SAM domain is unclear.


:

Pssm-ID: 188980  Cd Length: 85  Bit Score: 170.32  E-value: 7.05e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095 807 EEEKLILESNPLEWSVTDVVRFIKLTDCAPLARIFQEQDIDGQALLLLTLPTVQECMELKLGPAIKLCHQIERVKVAFYA 886
Cdd:cd09581    2 EEERLKLDSNPLFWSVDDVVRFIKSTDCAPLAKIFKDQEIDGQALLLLTLPTVQECMELKLGPAIKLCHHIERVKVAFYE 81

                 ....
gi 564392095 887 QYAN 890
Cdd:cd09581   82 QFAN 85
MBT super family cl45897
malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes ...
405-493 5.05e-44

malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes methylated lysine residues on histones and are thought to affect a variety of chromatin processes, including transcription. It exists as tandem repeats and is found in a number of nuclear proteins such as Drosophila sex comb on midleg protein. In the human genome, there are at least 9 MBT repeat proteins, each containing two, three or four MBT repeats. MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine (monomethyllysine and/or dimethyllysine).


The actual alignment was detected with superfamily member cd20118:

Pssm-ID: 459242  Cd Length: 91  Bit Score: 153.83  E-value: 5.05e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095 405 GFAKNMKLEAVNPKNPGEVCVATVISVRGSLLWLRLEGVETPMPEIIVDIDSMDIFPVGWCEANSYPLTTPYKSSSKSKK 484
Cdd:cd20118    1 GFTKNMKLEAVNPRNPAEICVASITSVKGRLLWLHLEGLQNPVPEYIVDVESMDIFPVGWCEANGYPLTPPHKAVCKKKR 80

                 ....*....
gi 564392095 485 KPITVPPEK 493
Cdd:cd20118   81 KIAVVQPEK 89
SLED pfam12140
SLED domain; The SLED (Scm-Like Embedded Domain) domain is a double-stranded DNA binding ...
527-641 2.87e-43

SLED domain; The SLED (Scm-Like Embedded Domain) domain is a double-stranded DNA binding domain found in Scml2 which is a member of the Polycomb group of proteins involved in epigenetic gene silencing.


:

Pssm-ID: 463469  Cd Length: 112  Bit Score: 152.36  E-value: 2.87e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095  527 CPQLFVNHRCFSGPFLNKGRISELPQSVGPGKCVLVLKEILTMITNAAYKPGRVLRELQLVEdpewDFQEEVLKAKYRGK 606
Cdd:pfam12140   1 TVCIYVNKNCFCGPHLDKKKIAELPDQFGPGPVSLVLKEVLQALIDCAYDPKQVLKLLKSGN----GGREEIITAKYEGK 76
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 564392095  607 IYRAVVKIVRTADQVTSFCQQVCAKLECCPNLFSP 641
Cdd:pfam12140  77 THTVKLPIVNSASDVWRFLEKLCEKLGCCENLFSP 111
 
Name Accession Description Interval E-value
MBT_SFMBT2_rpt1 cd20112
first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 ...
70-163 1.34e-68

first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.


Pssm-ID: 439102  Cd Length: 94  Bit Score: 222.17  E-value: 1.34e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095  70 QSNFQPGMKLEVANKNHPDTYWVATIITTCGQLLLLRYCGYGEDRRADFWCDVIIADLHPVGWCTQNNKVLRPPDAIKEK 149
Cdd:cd20112    1 QSSFQPGMKLEVANKSNPDTYWVATIITTCGQLLLLRYCGYGDDRRADFWCDVMTADLHPVGWCTQNNKVLMPPDAIKEK 80
                         90
                 ....*....|....
gi 564392095 150 YADWEEFLIHELTG 163
Cdd:cd20112   81 YTDWTEFLIHDLTG 94
MBT_SFMBT2_rpt3 cd20116
three malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 ...
297-389 7.23e-57

three malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439106  Cd Length: 93  Bit Score: 190.01  E-value: 7.23e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095 297 HFFTVGMRLETLHINDPFHIYPATVTKVFNSQFFQVAIDDLRAETNGLTMLCHADSLGILPVQWCLKNGVNLAPPKGYSG 376
Cdd:cd20116    1 HSFTVGMKLEVVDPREPFHICPASVTKVFNNHYFQVTVDDLRPEASENSMLCHADSLGILPVQWCLKNGVNLTPPKGYSG 80
                         90
                 ....*....|...
gi 564392095 377 QDFNWVDYHKQRE 389
Cdd:cd20116   81 QDFDWADYQKQCG 93
MBT_SFMBT2_rpt2 cd20114
second malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 ...
182-269 1.41e-50

second malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.


Pssm-ID: 439104  Cd Length: 98  Bit Score: 172.60  E-value: 1.41e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095 182 IDLITVDSLIELQDSQNPFQYWIVSVIENVGGRLRLRYVGLEHtESYDRWLFYLDYRLRPIGWCQEKKYRMDPPSELYYL 261
Cdd:cd20114    1 VDLITVGSLIELQDSQNPFQYWIVRVIENVGGRLRLRYVGLED-ESHDQWLFYLDTRLRPVGWCQENNLRMEPPTEICDL 79

                 ....*...
gi 564392095 262 KLPFEWKC 269
Cdd:cd20114   80 KSASEWKE 87
SAM_Scm-like-4MBT1,2 cd09581
SAM domain of Scm-like-4MBT1,2 proteins of Polycomb group; SAM (sterile alpha motif) domain of ...
807-890 7.05e-50

SAM domain of Scm-like-4MBT1,2 proteins of Polycomb group; SAM (sterile alpha motif) domain of Scm-like-4MBT1,2 (Sex comb on midleg, Malignant Brain Tumor) subfamily proteins (also known as Sfmbt1,2 proteins) is a putative protein-protein interaction domain. Proteins of this subfamily are transcriptional regulators belonging to Polycomb group. The majority of them are multidomain proteins: in addition to the C-terminal SAM domain, they contain four MBT repeats and DUF5388 domain. The MBT repeats of the human sfmbt1 protein are responsible for association with the nuclear matrix and for selective binding of H3 histone N-terminal tails, while the exact function of the SAM domain is unclear.


Pssm-ID: 188980  Cd Length: 85  Bit Score: 170.32  E-value: 7.05e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095 807 EEEKLILESNPLEWSVTDVVRFIKLTDCAPLARIFQEQDIDGQALLLLTLPTVQECMELKLGPAIKLCHQIERVKVAFYA 886
Cdd:cd09581    2 EEERLKLDSNPLFWSVDDVVRFIKSTDCAPLAKIFKDQEIDGQALLLLTLPTVQECMELKLGPAIKLCHHIERVKVAFYE 81

                 ....
gi 564392095 887 QYAN 890
Cdd:cd09581   82 QFAN 85
MBT_SFMBT2_rpt4 cd20118
fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 ...
405-493 5.05e-44

fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439108  Cd Length: 91  Bit Score: 153.83  E-value: 5.05e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095 405 GFAKNMKLEAVNPKNPGEVCVATVISVRGSLLWLRLEGVETPMPEIIVDIDSMDIFPVGWCEANSYPLTTPYKSSSKSKK 484
Cdd:cd20118    1 GFTKNMKLEAVNPRNPAEICVASITSVKGRLLWLHLEGLQNPVPEYIVDVESMDIFPVGWCEANGYPLTPPHKAVCKKKR 80

                 ....*....
gi 564392095 485 KPITVPPEK 493
Cdd:cd20118   81 KIAVVQPEK 89
SLED pfam12140
SLED domain; The SLED (Scm-Like Embedded Domain) domain is a double-stranded DNA binding ...
527-641 2.87e-43

SLED domain; The SLED (Scm-Like Embedded Domain) domain is a double-stranded DNA binding domain found in Scml2 which is a member of the Polycomb group of proteins involved in epigenetic gene silencing.


Pssm-ID: 463469  Cd Length: 112  Bit Score: 152.36  E-value: 2.87e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095  527 CPQLFVNHRCFSGPFLNKGRISELPQSVGPGKCVLVLKEILTMITNAAYKPGRVLRELQLVEdpewDFQEEVLKAKYRGK 606
Cdd:pfam12140   1 TVCIYVNKNCFCGPHLDKKKIAELPDQFGPGPVSLVLKEVLQALIDCAYDPKQVLKLLKSGN----GGREEIITAKYEGK 76
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 564392095  607 IYRAVVKIVRTADQVTSFCQQVCAKLECCPNLFSP 641
Cdd:pfam12140  77 THTVKLPIVNSASDVWRFLEKLCEKLGCCENLFSP 111
MBT smart00561
Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, ...
47-143 1.12e-36

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2. These proteins are involved in transcriptional regulation.


Pssm-ID: 214723  Cd Length: 96  Bit Score: 133.14  E-value: 1.12e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095    47 DYLDETGARAVPHVCFRHVEISIQSNFQPGMKLEVANKNHPDTYWVATIITTCGQLLLLRYCGYgeDRRADFWCDVIIAD 126
Cdd:smart00561   2 DYLEETGARAAPVELFKQPVDSPPNGFKVGMKLEAVDPRNPSLICVATVVEVKGYRLLLHFDGW--DDKYDFWCHADSPD 79
                           90
                   ....*....|....*..
gi 564392095   127 LHPVGWCTQNNKVLRPP 143
Cdd:smart00561  80 IFPVGWCEKNGHPLQPP 96
MBT smart00561
Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, ...
383-475 1.34e-31

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2. These proteins are involved in transcriptional regulation.


Pssm-ID: 214723  Cd Length: 96  Bit Score: 118.51  E-value: 1.34e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095   383 DYHKQREAEGAPPYCFKNT---FARGFAKNMKLEAVNPKNPGEVCVATVISVRGSLLWLRLEGVETPmPEIIVDIDSMDI 459
Cdd:smart00561   2 DYLEETGARAAPVELFKQPvdsPPNGFKVGMKLEAVDPRNPSLICVATVVEVKGYRLLLHFDGWDDK-YDFWCHADSPDI 80
                           90
                   ....*....|....*.
gi 564392095   460 FPVGWCEANSYPLTTP 475
Cdd:smart00561  81 FPVGWCEKNGHPLQPP 96
MBT pfam02820
mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear ...
410-475 3.53e-26

mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.


Pssm-ID: 460712  Cd Length: 66  Bit Score: 102.21  E-value: 3.53e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564392095  410 MKLEAVNPKNPGEVCVATVISVRGSLLWLRLEGVEtPMPEIIVDIDSMDIFPVGWCEANSYPLTTP 475
Cdd:pfam02820   1 MKLEAVDPLNPSLICVATVVKVLGGRLRLRFDGWD-DSYDFWCHADSPDIHPVGWCEKNGHPLQPP 65
MBT pfam02820
mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear ...
77-144 5.35e-24

mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.


Pssm-ID: 460712  Cd Length: 66  Bit Score: 95.66  E-value: 5.35e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564392095   77 MKLEVANKNHPDTYWVATIITTCGQLLLLRYCGYgeDRRADFWCDVIIADLHPVGWCTQNNKVLRPPD 144
Cdd:pfam02820   1 MKLEAVDPLNPSLICVATVVKVLGGRLRLRFDGW--DDSYDFWCHADSPDIHPVGWCEKNGHPLQPPK 66
MBT smart00561
Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, ...
154-255 5.38e-24

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2. These proteins are involved in transcriptional regulation.


Pssm-ID: 214723  Cd Length: 96  Bit Score: 96.93  E-value: 5.38e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095   154 EEFLihELTGSRTAPASLLEGPlrGKGPIDLITVDSLIELQDSQNPFQYWIVSVIENVGGRLRLRYVGLEhtESYDRWLF 233
Cdd:smart00561   1 EDYL--EETGARAAPVELFKQP--VDSPPNGFKVGMKLEAVDPRNPSLICVATVVEVKGYRLLLHFDGWD--DKYDFWCH 74
                           90       100
                   ....*....|....*....|..
gi 564392095   234 YLDYRLRPIGWCQEKKYRMDPP 255
Cdd:smart00561  75 ADSPDIFPVGWCEKNGHPLQPP 96
MBT smart00561
Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, ...
281-371 3.36e-21

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2. These proteins are involved in transcriptional regulation.


Pssm-ID: 214723  Cd Length: 96  Bit Score: 88.85  E-value: 3.36e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095   281 CPLPMEVFKDHADLGSHFFTVGMRLETLHINDPFHIYPATVTKVFNsQFFQVAIDDLRAEtngLTMLCHADSLGILPVQW 360
Cdd:smart00561  10 RAAPVELFKQPVDSPPNGFKVGMKLEAVDPRNPSLICVATVVEVKG-YRLLLHFDGWDDK---YDFWCHADSPDIFPVGW 85
                           90
                   ....*....|.
gi 564392095   361 CLKNGVNLAPP 371
Cdd:smart00561  86 CEKNGHPLQPP 96
MBT pfam02820
mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear ...
303-372 1.78e-17

mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.


Pssm-ID: 460712  Cd Length: 66  Bit Score: 77.17  E-value: 1.78e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095  303 MRLETLHINDPFHIYPATVTKVFnSQFFQVAIDDLRAEtngLTMLCHADSLGILPVQWCLKNGVNLAPPK 372
Cdd:pfam02820   1 MKLEAVDPLNPSLICVATVVKVL-GGRLRLRFDGWDDS---YDFWCHADSPDIHPVGWCEKNGHPLQPPK 66
MBT pfam02820
mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear ...
191-255 3.31e-17

mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.


Pssm-ID: 460712  Cd Length: 66  Bit Score: 76.40  E-value: 3.31e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564392095  191 IELQDSQNPFQYWIVSVIENVGGRLRLRYVGLEhtESYDRWLFYLDYRLRPIGWCQEKKYRMDPP 255
Cdd:pfam02820   3 LEAVDPLNPSLICVATVVKVLGGRLRLRFDGWD--DSYDFWCHADSPDIHPVGWCEKNGHPLQPP 65
SAM smart00454
Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related ...
817-881 2.90e-06

Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylated. In many cases mediates homodimerisation.


Pssm-ID: 197735  Cd Length: 68  Bit Score: 45.36  E-value: 2.90e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564392095   817 PLEWSVTDVVRFIKLTDCAPLARIFQEQDIDGQALLLLtlpTVQECME----LKLGPAIKLCHQIERVK 881
Cdd:smart00454   1 VSQWSPESVADWLESIGLEQYADNFRKNGIDGALLLLL---TSEEDLKelgiTKLGHRKKILKAIQKLK 66
SAM_1 pfam00536
SAM domain (Sterile alpha motif); It has been suggested that SAM is an evolutionarily ...
819-881 5.24e-06

SAM domain (Sterile alpha motif); It has been suggested that SAM is an evolutionarily conserved protein binding domain that is involved in the regulation of numerous developmental processes in diverse eukaryotes. The SAM domain can potentially function as a protein interaction module through its ability to homo- and heterooligomerise with other SAM domains.


Pssm-ID: 425739  Cd Length: 64  Bit Score: 44.57  E-value: 5.24e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564392095  819 EWSVTDVVRFIKLTDCAPLARIFQEQDIDGQALLLLtlpTVQECMEL---KLGPAIKLCHQIERVK 881
Cdd:pfam00536   2 GWSVEDVGEWLESIGLGQYIDSFRAGYIDGDALLQL---TEDDLLKLgvtLLGHRKKILYAIQRLK 64
 
Name Accession Description Interval E-value
MBT_SFMBT2_rpt1 cd20112
first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 ...
70-163 1.34e-68

first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.


Pssm-ID: 439102  Cd Length: 94  Bit Score: 222.17  E-value: 1.34e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095  70 QSNFQPGMKLEVANKNHPDTYWVATIITTCGQLLLLRYCGYGEDRRADFWCDVIIADLHPVGWCTQNNKVLRPPDAIKEK 149
Cdd:cd20112    1 QSSFQPGMKLEVANKSNPDTYWVATIITTCGQLLLLRYCGYGDDRRADFWCDVMTADLHPVGWCTQNNKVLMPPDAIKEK 80
                         90
                 ....*....|....
gi 564392095 150 YADWEEFLIHELTG 163
Cdd:cd20112   81 YTDWTEFLIHDLTG 94
MBT_SFMBT2_rpt3 cd20116
three malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 ...
297-389 7.23e-57

three malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439106  Cd Length: 93  Bit Score: 190.01  E-value: 7.23e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095 297 HFFTVGMRLETLHINDPFHIYPATVTKVFNSQFFQVAIDDLRAETNGLTMLCHADSLGILPVQWCLKNGVNLAPPKGYSG 376
Cdd:cd20116    1 HSFTVGMKLEVVDPREPFHICPASVTKVFNNHYFQVTVDDLRPEASENSMLCHADSLGILPVQWCLKNGVNLTPPKGYSG 80
                         90
                 ....*....|...
gi 564392095 377 QDFNWVDYHKQRE 389
Cdd:cd20116   81 QDFDWADYQKQCG 93
MBT_SFMBT_rpt1 cd20093
first malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein ...
70-163 1.77e-55

first malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.


Pssm-ID: 439083  Cd Length: 94  Bit Score: 185.94  E-value: 1.77e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095  70 QSNFQPGMKLEVANKNHPDTYWVATIITTCGQLLLLRYCGYGEDRRADFWCDVIIADLHPVGWCTQNNKVLRPPDAIKEK 149
Cdd:cd20093    1 QSGFKPGMKLEVPNKNNPDTYWVATVVMTCGPLLRLRYVGYEDDRSADFWCDLSSGDVHPIGWCAQNGKPLQPPADIKEK 80
                         90
                 ....*....|....
gi 564392095 150 YADWEEFLIHELTG 163
Cdd:cd20093   81 ELDWAEFLIKELTG 94
MBT_SFMBT1_rpt1 cd20111
first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 ...
70-163 1.17e-54

first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.


Pssm-ID: 439101  Cd Length: 94  Bit Score: 183.88  E-value: 1.17e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095  70 QSNFQPGMKLEVANKNHPDTYWVATIITTCGQLLLLRYCGYGEDRRADFWCDVIIADLHPVGWCTQNNKVLRPPDAIKEK 149
Cdd:cd20111    1 QNGFSPGMKLEVAVRTDPNTYWVATIITTCGQLLLLRYDGYGEDRRADFWCDIMTADLHPIGWCEQNGKTLRPPEGIRDK 80
                         90
                 ....*....|....
gi 564392095 150 YADWEEFLIHELTG 163
Cdd:cd20111   81 LSDWEEFLAQTLTG 94
MBT_SFMBT2_rpt2 cd20114
second malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 ...
182-269 1.41e-50

second malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.


Pssm-ID: 439104  Cd Length: 98  Bit Score: 172.60  E-value: 1.41e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095 182 IDLITVDSLIELQDSQNPFQYWIVSVIENVGGRLRLRYVGLEHtESYDRWLFYLDYRLRPIGWCQEKKYRMDPPSELYYL 261
Cdd:cd20114    1 VDLITVGSLIELQDSQNPFQYWIVRVIENVGGRLRLRYVGLED-ESHDQWLFYLDTRLRPVGWCQENNLRMEPPTEICDL 79

                 ....*...
gi 564392095 262 KLPFEWKC 269
Cdd:cd20114   80 KSASEWKE 87
SAM_Scm-like-4MBT1,2 cd09581
SAM domain of Scm-like-4MBT1,2 proteins of Polycomb group; SAM (sterile alpha motif) domain of ...
807-890 7.05e-50

SAM domain of Scm-like-4MBT1,2 proteins of Polycomb group; SAM (sterile alpha motif) domain of Scm-like-4MBT1,2 (Sex comb on midleg, Malignant Brain Tumor) subfamily proteins (also known as Sfmbt1,2 proteins) is a putative protein-protein interaction domain. Proteins of this subfamily are transcriptional regulators belonging to Polycomb group. The majority of them are multidomain proteins: in addition to the C-terminal SAM domain, they contain four MBT repeats and DUF5388 domain. The MBT repeats of the human sfmbt1 protein are responsible for association with the nuclear matrix and for selective binding of H3 histone N-terminal tails, while the exact function of the SAM domain is unclear.


Pssm-ID: 188980  Cd Length: 85  Bit Score: 170.32  E-value: 7.05e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095 807 EEEKLILESNPLEWSVTDVVRFIKLTDCAPLARIFQEQDIDGQALLLLTLPTVQECMELKLGPAIKLCHQIERVKVAFYA 886
Cdd:cd09581    2 EEERLKLDSNPLFWSVDDVVRFIKSTDCAPLAKIFKDQEIDGQALLLLTLPTVQECMELKLGPAIKLCHHIERVKVAFYE 81

                 ....
gi 564392095 887 QYAN 890
Cdd:cd09581   82 QFAN 85
MBT_SFMBT2_rpt4 cd20118
fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 ...
405-493 5.05e-44

fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439108  Cd Length: 91  Bit Score: 153.83  E-value: 5.05e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095 405 GFAKNMKLEAVNPKNPGEVCVATVISVRGSLLWLRLEGVETPMPEIIVDIDSMDIFPVGWCEANSYPLTTPYKSSSKSKK 484
Cdd:cd20118    1 GFTKNMKLEAVNPRNPAEICVASITSVKGRLLWLHLEGLQNPVPEYIVDVESMDIFPVGWCEANGYPLTPPHKAVCKKKR 80

                 ....*....
gi 564392095 485 KPITVPPEK 493
Cdd:cd20118   81 KIAVVQPEK 89
SLED pfam12140
SLED domain; The SLED (Scm-Like Embedded Domain) domain is a double-stranded DNA binding ...
527-641 2.87e-43

SLED domain; The SLED (Scm-Like Embedded Domain) domain is a double-stranded DNA binding domain found in Scml2 which is a member of the Polycomb group of proteins involved in epigenetic gene silencing.


Pssm-ID: 463469  Cd Length: 112  Bit Score: 152.36  E-value: 2.87e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095  527 CPQLFVNHRCFSGPFLNKGRISELPQSVGPGKCVLVLKEILTMITNAAYKPGRVLRELQLVEdpewDFQEEVLKAKYRGK 606
Cdd:pfam12140   1 TVCIYVNKNCFCGPHLDKKKIAELPDQFGPGPVSLVLKEVLQALIDCAYDPKQVLKLLKSGN----GGREEIITAKYEGK 76
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 564392095  607 IYRAVVKIVRTADQVTSFCQQVCAKLECCPNLFSP 641
Cdd:pfam12140  77 THTVKLPIVNSASDVWRFLEKLCEKLGCCENLFSP 111
MBT smart00561
Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, ...
47-143 1.12e-36

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2. These proteins are involved in transcriptional regulation.


Pssm-ID: 214723  Cd Length: 96  Bit Score: 133.14  E-value: 1.12e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095    47 DYLDETGARAVPHVCFRHVEISIQSNFQPGMKLEVANKNHPDTYWVATIITTCGQLLLLRYCGYgeDRRADFWCDVIIAD 126
Cdd:smart00561   2 DYLEETGARAAPVELFKQPVDSPPNGFKVGMKLEAVDPRNPSLICVATVVEVKGYRLLLHFDGW--DDKYDFWCHADSPD 79
                           90
                   ....*....|....*..
gi 564392095   127 LHPVGWCTQNNKVLRPP 143
Cdd:smart00561  80 IFPVGWCEKNGHPLQPP 96
MBT_SFMBT_rpt3 cd20095
third malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein ...
299-387 3.45e-36

third malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439085  Cd Length: 92  Bit Score: 131.61  E-value: 3.45e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095 299 FTVGMRLETLHINDPFHIYPATVTKVFNSQFFQVAIDDLRAETNG-LTMLCHADSLGILPVQWCLKNGVNLAPPKGYSGQ 377
Cdd:cd20095    1 FKVGMKLEALHPKNPSTICPATVTKVFNEYYFLVEIDDLRPEESEkITFVCHANSPGIFPVGWCAKNGLRLTPPPGYPKS 80
                         90
                 ....*....|
gi 564392095 378 DFNWVDYHKQ 387
Cdd:cd20095   81 EFDWDSYLKL 90
MBT_SFMBT1_rpt3 cd20115
third malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 ...
297-387 7.40e-35

third malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439105  Cd Length: 94  Bit Score: 127.68  E-value: 7.40e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095 297 HFFTVGMRLETLHINDPFHIYPATVTKVFNSQFFQVAIDDLRAETNGL-TMLCHADSLGILPVQWCLKNGVNLAPPKGYS 375
Cdd:cd20115    1 HCFSEGMKLEAVDPAAPFTISPATVAKVFNEKFFLVEMDDLRPEEAGAhSFVCHRDSPGIFPVQWSLKNGLHLSPPPGYP 80
                         90
                 ....*....|..
gi 564392095 376 GQDFNWVDYHKQ 387
Cdd:cd20115   81 GQDFDWADYLKQ 92
MBT_SFMBT_rpt2 cd20094
second malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein ...
182-269 1.01e-34

second malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.


Pssm-ID: 439084  Cd Length: 91  Bit Score: 127.35  E-value: 1.01e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095 182 IDLITVDSLIELQDSQNPFQYWIVSVIENVGGRLRLRYVGLEHTESYDRWLFYLDYRLRPIGWCQEKKYRMDPPSELYYL 261
Cdd:cd20094    1 ADRIKVGMYLEVQDELNPYSVWIAKVLENVGGRLLLRYDGPEDSDSPDFWLFYLSPRLHPLGWAKSNGYTYRPPKSLEKL 80

                 ....*...
gi 564392095 262 KLPFEWKC 269
Cdd:cd20094   81 HATEEWKA 88
MBT_SFMBT_rpt4 cd20096
fourth malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein ...
406-475 4.97e-34

fourth malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439086  Cd Length: 73  Bit Score: 124.66  E-value: 4.97e-34
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095 406 FAKNMKLEAVNPKNPGEVCVATVISVRGSLLWLRLEGVETPMPEIIVDIDSMDIFPVGWCEANSYPLTTP 475
Cdd:cd20096    1 FERGMKLEAVNPENPNQICVATITKVVGPLLWLHLDSEKKLSPNIIVDVESTDIFPVGWCESNGYPLVTP 70
MBT smart00561
Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, ...
383-475 1.34e-31

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2. These proteins are involved in transcriptional regulation.


Pssm-ID: 214723  Cd Length: 96  Bit Score: 118.51  E-value: 1.34e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095   383 DYHKQREAEGAPPYCFKNT---FARGFAKNMKLEAVNPKNPGEVCVATVISVRGSLLWLRLEGVETPmPEIIVDIDSMDI 459
Cdd:smart00561   2 DYLEETGARAAPVELFKQPvdsPPNGFKVGMKLEAVDPRNPSLICVATVVEVKGYRLLLHFDGWDDK-YDFWCHADSPDI 80
                           90
                   ....*....|....*.
gi 564392095   460 FPVGWCEANSYPLTTP 475
Cdd:smart00561  81 FPVGWCEKNGHPLQPP 96
MBT_dSfmbt_rpt1 cd20119
first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein ...
76-168 2.05e-30

first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.


Pssm-ID: 439109  Cd Length: 104  Bit Score: 115.62  E-value: 2.05e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095  76 GMKLEVANKN-----HPDTYWVATIITTCGQLLLLRYCGYGEDRRADFWCDVIIADLHPVGWCTQNNKVLRPPDAIKEKY 150
Cdd:cd20119    7 GMKVEVENTDtdlieDPTSFWIATVLKIAGYKALMRYEGFGTDDSKDFWVNLCSEDVHPVGWCATRGKPLIPPRTIEHKY 86
                         90
                 ....*....|....*...
gi 564392095 151 ADWEEFLIHELTGSRTAP 168
Cdd:cd20119   87 SDWKEFLVKRLTGARTLP 104
MBT_SFMBT1_rpt4 cd20117
fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 ...
405-493 2.36e-30

fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439107  Cd Length: 90  Bit Score: 114.98  E-value: 2.36e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095 405 GFAKNMKLEAVNPKNPGEVCVATVISVRGSLLWLRLEGVETPMPEIIVDIDSMDIFPVGWCEANSYPLTTPYKSSSKSKK 484
Cdd:cd20117    2 CFKENMKLEAVNPICPEEICVATVTKVKGSYLWLQLEGSKKPIPECIVHVESMDIFPVGWCETNGYPLLHPRKARVNKQR 81

                 ....*....
gi 564392095 485 KPITVPPEK 493
Cdd:cd20117   82 KIAVVQPEK 90
MBT_dSfmbt-like_rpt1 cd20097
first malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein ...
70-168 2.44e-30

first malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.


Pssm-ID: 439087  Cd Length: 105  Bit Score: 115.48  E-value: 2.44e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095  70 QSNFQPGMKLEVANKNHPD------TYWVATIITTCGQLLLLRYCGYGEDRRADFWCDVIIADLHPVGWCTQNNKVLRPP 143
Cdd:cd20097    1 WEKVKIGVKVEVANRDDDKptdnvkVYWFARIIKVAGYRVLLRYEGYDEDSSHDFWINLCSNEIHPIGYAAENGKILVPP 80
                         90       100
                 ....*....|....*....|....*
gi 564392095 144 DAIKEKYADWEEFLIHELTGSRTAP 168
Cdd:cd20097   81 KSIEDKENDWKEYIMKRLHGKRTIP 105
MBT_MBTD1_rpt1 cd20120
first malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); ...
76-168 1.33e-28

first malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.


Pssm-ID: 439110  Cd Length: 103  Bit Score: 110.33  E-value: 1.33e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095  76 GMKLEVANKNHP---DTYWVATIITTCGQLLLLRYCGYGEDRRADFWCDVIIADLHPVGWCTQNNKVLRPPDAIKEKYAD 152
Cdd:cd20120    7 GVRVEVPNTDCNlptKVFWIAGIVKLAGYKALLRYEGFENDSSLDFWCNICGSDIHPVGWCATSGKPLVPPKTIQHKYTN 86
                         90
                 ....*....|....*.
gi 564392095 153 WEEFLIHELTGSRTAP 168
Cdd:cd20120   87 WKAFLVKRLTGAKTLP 102
MBT_SFMBT1_rpt2 cd20113
second malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 ...
182-268 3.18e-28

second malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.


Pssm-ID: 439103  Cd Length: 99  Bit Score: 109.13  E-value: 3.18e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095 182 IDLITVDSLIELQDSQNPFQYWIVSVIENVGGRLRLRYVGLEHTESYDRWLFYLDYRLRPIGWCQEKKYRMDPPSELYYL 261
Cdd:cd20113    1 LDLIGPGSRLELQDFQDSLVAWIVVVVENIGGRLKLRYEGLEGSDKSDTWLFYLDPFLHQVGWAAQHGYTLQPPAAIRHL 80

                 ....*..
gi 564392095 262 KLPFEWK 268
Cdd:cd20113   81 KSEAEWQ 87
SAM_Polycomb cd09509
SAM domain of Polycomb group; SAM (sterile alpha motif) domain of Polycomb group is a ...
817-879 1.17e-27

SAM domain of Polycomb group; SAM (sterile alpha motif) domain of Polycomb group is a protein-protein interaction domain. The Polycomb group includes transcriptional repressors which are involved in the regulation of some key regulatory genes during development in many organisms. They are best known for silencing Hox (Homeobox) genes. Polycomb proteins work together in large multimeric and chromatin-associated complexes. They organize chromatin of the target genes and maintain repressed states during many cell divisions. Polycomb proteins are classified based on their common function, but not on conserved domains and/or motifs; however many Polycomb proteins (members of PRC1 class complex) contain SAM domains which are more similar to each other inside of the Polycomb group than to SAM domains outside of it. Most information about structure and function of Polycomb SAM domains comes from studies of Ph (Polyhomeotic) and Scm (Sex comb on midleg) proteins. Polycomb SAM domains usually can be found at the C-terminus of the proteins. Some members of this group contain, in addition to the SAM domain, MTB repeats, Zn finger, and/or DUF3588 domains. Polycomb SAM domains can form homo- and/or heterooligomers through ML and EH surfaces. SAM/SAM oligomers apparently play a role in transcriptional repression through polymerization along the chromosome. Polycomb proteins are known to be highly expressed in some cells years before their cancer pathology; thus they are attractive markers for early cancer therapy.


Pssm-ID: 188908  Cd Length: 64  Bit Score: 106.02  E-value: 1.17e-27
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564392095 817 PLEWSVTDVVRFIKLTD-CAPLARIFQEQDIDGQALLLLTLPTVQECMELKLGPAIKLCHQIER 879
Cdd:cd09509    1 PSKWSVDDVAQFIKSLDgCAEYAEVFREQEIDGQALLLLTEDDLLKGMGLKLGPALKIYNHIVK 64
MBT_L3MBTL2_rpt1 cd20121
first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
76-168 4.81e-27

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2) and similar proteins; L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.


Pssm-ID: 439111  Cd Length: 102  Bit Score: 105.70  E-value: 4.81e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095  76 GMKLEVANK--NHPD-TYWVATIITTCGQLLLLRYCGYGEDRRADFWCDVIIADLHPVGWCTQNNKVLRPPDAIKEKYAD 152
Cdd:cd20121    7 GMKVEVLNTdaVLPSrVYWIASVIQLAGYKALLRYEGFENDSSHDFWCNLGTVDVHPIGWCAINSKILVPPQTIHAKFTD 86
                         90
                 ....*....|....*.
gi 564392095 153 WEEFLIHELTGSRTAP 168
Cdd:cd20121   87 WRGYLMKRLVGSRTIP 102
MBT pfam02820
mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear ...
410-475 3.53e-26

mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.


Pssm-ID: 460712  Cd Length: 66  Bit Score: 102.21  E-value: 3.53e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564392095  410 MKLEAVNPKNPGEVCVATVISVRGSLLWLRLEGVEtPMPEIIVDIDSMDIFPVGWCEANSYPLTTP 475
Cdd:pfam02820   1 MKLEAVDPLNPSLICVATVVKVLGGRLRLRFDGWD-DSYDFWCHADSPDIHPVGWCEKNGHPLQPP 65
MBT pfam02820
mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear ...
77-144 5.35e-24

mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.


Pssm-ID: 460712  Cd Length: 66  Bit Score: 95.66  E-value: 5.35e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564392095   77 MKLEVANKNHPDTYWVATIITTCGQLLLLRYCGYgeDRRADFWCDVIIADLHPVGWCTQNNKVLRPPD 144
Cdd:pfam02820   1 MKLEAVDPLNPSLICVATVVKVLGGRLRLRFDGW--DDSYDFWCHADSPDIHPVGWCEKNGHPLQPPK 66
MBT smart00561
Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, ...
154-255 5.38e-24

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2. These proteins are involved in transcriptional regulation.


Pssm-ID: 214723  Cd Length: 96  Bit Score: 96.93  E-value: 5.38e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095   154 EEFLihELTGSRTAPASLLEGPlrGKGPIDLITVDSLIELQDSQNPFQYWIVSVIENVGGRLRLRYVGLEhtESYDRWLF 233
Cdd:smart00561   1 EDYL--EETGARAAPVELFKQP--VDSPPNGFKVGMKLEAVDPRNPSLICVATVVEVKGYRLLLHFDGWD--DKYDFWCH 74
                           90       100
                   ....*....|....*....|..
gi 564392095   234 YLDYRLRPIGWCQEKKYRMDPP 255
Cdd:smart00561  75 ADSPDIFPVGWCEKNGHPLQPP 96
MBT cd20088
malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes ...
73-134 8.77e-24

malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes methylated lysine residues on histones and are thought to affect a variety of chromatin processes, including transcription. It exists as tandem repeats and is found in a number of nuclear proteins such as Drosophila sex comb on midleg protein. In the human genome, there are at least 9 MBT repeat proteins, each containing two, three or four MBT repeats. MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine (monomethyllysine and/or dimethyllysine).


Pssm-ID: 439080  Cd Length: 61  Bit Score: 95.02  E-value: 8.77e-24
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564392095  73 FQPGMKLEVANKNHPDTYWVATIITTCGQLLLLRYCGYgEDRRADFWCDVIIADLHPVGWCT 134
Cdd:cd20088    1 FKVGMKLEAVDPLNPSEICVATVVKVVGGRLLLHFDGW-DPSRYDFWCDVDSPDIHPVGWCE 61
MBT_SCMH1_rpt1 cd20105
first malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog ...
43-173 6.47e-22

first malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog 1; Sex comb on midleg homolog 1 (SCMH1) is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. It contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439095  Cd Length: 131  Bit Score: 92.36  E-value: 6.47e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095  43 FSWGDYLDETGARAVPHVCFRHVEISIQSNFQPGMKLEVANKNHPDTYWVATIITTCGQLLLLRYcgYGEDRRADFWCDV 122
Cdd:cd20105    2 FSWDKYLKETGAVPAPVHCFKQSYTPPVNEFKIGMKLEAQDPRNTTSTCIATVVGLTGARLRLRL--DGSDNKNDFWRLV 79
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 564392095 123 IIADLHPVGWCTQNNKVLRPPDAIKEKYADWEEFLIHELTGSRTAPASLLE 173
Cdd:cd20105   80 DSSEIQPIGNCEKNGGMLQPPLGFRLNASSWPMFLLKTLNGAEMAPVRIFH 130
MBT cd20088
malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes ...
406-466 7.87e-22

malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes methylated lysine residues on histones and are thought to affect a variety of chromatin processes, including transcription. It exists as tandem repeats and is found in a number of nuclear proteins such as Drosophila sex comb on midleg protein. In the human genome, there are at least 9 MBT repeat proteins, each containing two, three or four MBT repeats. MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine (monomethyllysine and/or dimethyllysine).


Pssm-ID: 439080  Cd Length: 61  Bit Score: 89.62  E-value: 7.87e-22
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564392095 406 FAKNMKLEAVNPKNPGEVCVATVISVRGSLLWLRLEGVETPMPEIIVDIDSMDIFPVGWCE 466
Cdd:cd20088    1 FKVGMKLEAVDPLNPSEICVATVVKVVGGRLLLHFDGWDPSRYDFWCDVDSPDIHPVGWCE 61
MBT smart00561
Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, ...
281-371 3.36e-21

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2. These proteins are involved in transcriptional regulation.


Pssm-ID: 214723  Cd Length: 96  Bit Score: 88.85  E-value: 3.36e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095   281 CPLPMEVFKDHADLGSHFFTVGMRLETLHINDPFHIYPATVTKVFNsQFFQVAIDDLRAEtngLTMLCHADSLGILPVQW 360
Cdd:smart00561  10 RAAPVELFKQPVDSPPNGFKVGMKLEAVDPRNPSLICVATVVEVKG-YRLLLHFDGWDDK---YDFWCHADSPDIFPVGW 85
                           90
                   ....*....|.
gi 564392095   361 CLKNGVNLAPP 371
Cdd:smart00561  86 CEKNGHPLQPP 96
SAM_Scm cd09578
SAM domain of Scm proteins of Polycomb group; SAM (sterile alpha motif) domain of Scm (Sex ...
815-881 1.61e-19

SAM domain of Scm proteins of Polycomb group; SAM (sterile alpha motif) domain of Scm (Sex comb on midleg) subfamily of Polycomb group is a protein-protein interaction domain. Proteins of this subfamily are transcriptional repressors associated with PRC1 complex. This group includes invertebrate Scm protein and chordate Scm homolog 1 and Scm-like 1, 2, 3 proteins. Most have a SAM domain, two MBT repeats, and a DUF3588 domain, except Scm-like 4 proteins which do not have MBT repeats. Originally the Scm protein was described in Drosophila as a regulator required for proper spatial expression of homeotic genes. It plays a major role during early embryogenesis. SAM domains of Scm proteins can interact with each other, forming homooligomers, as well as with SAM domains of other proteins, in particular with SAM domains of Ph (polyhomeotic) proteins, forming heterooligomers. Homooligomers are similar to the ones formed by SAM Pointed domains of the TEL proteins. Such SAM/SAM oligomers apparently play a role in transcriptional repression through polymerization along the chromosome. Mammalian Scmh1 protein is known be indispensible member of PRC1 complex; it plays a regulatory role for the complex during meiotic prophase of male sperm cells, and is particularly involved in regulation of chromatin modification at the XY chromatin domain of the pachytene spermatocytes.


Pssm-ID: 188977  Cd Length: 72  Bit Score: 83.24  E-value: 1.61e-19
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095 815 SNPLEWSVTDVVRFIKLTD---CAPLARIFQEQDIDGQALLLLTLPTVQECMELKLGPAIKLCHQIERVK 881
Cdd:cd09578    2 KDPSTWSVEDVVQFIKEADpqaLAPHVDLFRKHEIDGKALLLLNSDMMMKYMGLKLGPALKLCYHIDKLK 71
MBT_L3MBTL1-like_rpt1 cd20101
first malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like ...
71-172 3.48e-19

first malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage and may bind methylated lysine residues.


Pssm-ID: 439091  Cd Length: 101  Bit Score: 83.47  E-value: 3.48e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095  71 SNFQPGMKLEVANKNHPDTYWVATIITTCGQLLLLRYCGYGEDRraDFWCDVIIADLHPVGWCTQNNKVLRPPDAIKEKY 150
Cdd:cd20101    4 NGFKVGMKLEGIDPKHPSLFCVLSVAEVRGYRLRLHFDGYSECY--DFWVNADSPDIFPVGWCEKTGHKLQPPKGYTSET 81
                         90       100
                 ....*....|....*....|..
gi 564392095 151 ADWEEFLihELTGSRTAPASLL 172
Cdd:cd20101   82 FSWSAYL--KLTKAQAAPKHLF 101
MBT_dSfmbt-like_rpt3 cd20099
third malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein ...
299-384 1.29e-18

third malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439089 [Multi-domain]  Cd Length: 91  Bit Score: 81.19  E-value: 1.29e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095 299 FTVGMRLETLHINDPFHIYPATVTKVFNSQFFQVAIDDLRAETNGLTMLCHADSLGILPVQWCLKNGVNLAPPKGYSGQD 378
Cdd:cd20099    1 FKVGMKLEAVDPLNLSSICVATVRKVLRFGYLVIGIDGPSADDGSDWFCCHASSPFIFPVGFAEKNGIELTPPRGYESKP 80

                 ....*.
gi 564392095 379 FNWVDY 384
Cdd:cd20099   81 FDWEEY 86
MBT_L3MBTL1-like_rpt2 cd20102
second malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like ...
73-157 7.09e-18

second malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439092  Cd Length: 90  Bit Score: 79.21  E-value: 7.09e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095  73 FQPGMKLEVANKNHPDTYWVATIITTCGQLLLLRYCGYgeDRRADFWCDVIIADLHPVGWCTQNNKVLRPPDAIKEKYAD 152
Cdd:cd20102    4 FRVGMKLEAVDRKNPSLICVATVTDVIGNRFLVHFDGW--DDSYDYWCDPDSPYIHPVGWCEENGKTLQPPKGYSPGNFS 81

                 ....*
gi 564392095 153 WEEFL 157
Cdd:cd20102   82 WDKYL 86
MBT cd20088
malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes ...
185-246 1.18e-17

malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes methylated lysine residues on histones and are thought to affect a variety of chromatin processes, including transcription. It exists as tandem repeats and is found in a number of nuclear proteins such as Drosophila sex comb on midleg protein. In the human genome, there are at least 9 MBT repeat proteins, each containing two, three or four MBT repeats. MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine (monomethyllysine and/or dimethyllysine).


Pssm-ID: 439080  Cd Length: 61  Bit Score: 77.68  E-value: 1.18e-17
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564392095 185 ITVDSLIELQDSQNPFQYWIVSVIENVGGRLRLRYVGLEHtESYDRWLFYLDYRLRPIGWCQ 246
Cdd:cd20088    1 FKVGMKLEAVDPLNPSEICVATVVKVVGGRLLLHFDGWDP-SRYDFWCDVDSPDIHPVGWCE 61
MBT pfam02820
mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear ...
303-372 1.78e-17

mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.


Pssm-ID: 460712  Cd Length: 66  Bit Score: 77.17  E-value: 1.78e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095  303 MRLETLHINDPFHIYPATVTKVFnSQFFQVAIDDLRAEtngLTMLCHADSLGILPVQWCLKNGVNLAPPK 372
Cdd:pfam02820   1 MKLEAVDPLNPSLICVATVVKVL-GGRLRLRFDGWDDS---YDFWCHADSPDIHPVGWCEKNGHPLQPPK 66
MBT pfam02820
mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear ...
191-255 3.31e-17

mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.


Pssm-ID: 460712  Cd Length: 66  Bit Score: 76.40  E-value: 3.31e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564392095  191 IELQDSQNPFQYWIVSVIENVGGRLRLRYVGLEhtESYDRWLFYLDYRLRPIGWCQEKKYRMDPP 255
Cdd:pfam02820   3 LEAVDPLNPSLICVATVVKVLGGRLRLRFDGWD--DSYDFWCHADSPDIHPVGWCEKNGHPLQPP 65
MBT_L3MBTL3_rpt1 cd20132
first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
70-172 4.35e-17

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439122  Cd Length: 101  Bit Score: 77.27  E-value: 4.35e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095  70 QSNFQPGMKLEVANKNHPDTYWVATIITTCGQLLLLRYCGYGEDRraDFWCDVIIADLHPVGWCTQNNKVLRPPDAIKEK 149
Cdd:cd20132    3 KNGFKVGMKLEGVDPEHQSMYCVLTVAEVCGYRIRLHFDGYSDCY--DFWVNADSPDIHPVGWCEKTGHKLHPPKGYKEE 80
                         90       100
                 ....*....|....*....|...
gi 564392095 150 YADWEEFLihELTGSRTAPASLL 172
Cdd:cd20132   81 EFNWQSYL--KTCKAQAAPKSLF 101
SAM_Ph1,2,3 cd09577
SAM domain of Ph (polyhomeotic) proteins of Polycomb group; SAM (sterile alpha motif) domain ...
815-881 7.50e-17

SAM domain of Ph (polyhomeotic) proteins of Polycomb group; SAM (sterile alpha motif) domain of Ph (polyhomeotic) proteins of Polycomb group is a protein-protein interaction domain. Ph1,2,3 proteins are members of PRC1 complex. This complex is involved in transcriptional repression of Hox (Homeobox) cluster genes. It is recruited through methylated H3Lys27 and supports the repression state by mediating monoubiquitination of histone H2A. Proteins of the Ph1,2,3 subfamily contribute to anterior-posterior neural tissue specification during embryogenesis. Additionally, the P2 protein of zebrafish is known to be involved in epiboly and tailbud formation. SAM domains of Ph proteins may interact with each other, forming homooligomers, as well as with SAM domains of other proteins, in particular with the SAM domain of Scm (sex comb on midleg) proteins, forming heterooligomers. Homooligomers are similar to the ones formed by SAM Pointed domains of the TEL proteins. Such SAM/SAM oligomers apparently play a role in transcriptional repression through polymerization along the chromosome.


Pssm-ID: 188976  Cd Length: 69  Bit Score: 75.52  E-value: 7.50e-17
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564392095 815 SNPLEWSVTDVVRFIK-LTDCAPLARIFQEQDIDGQALLLLTLPTVQECMELKLGPAIKLCHQIERVK 881
Cdd:cd09577    1 SNPSKWSVEDVYEFIRsLPGCSDYAEEFRAQEIDGQALLLLKEDHLMSAMNIKLGPALKICAKINSLK 68
MBT_L3MBTL1-like_rpt2 cd20102
second malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like ...
404-475 7.78e-17

second malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439092  Cd Length: 90  Bit Score: 76.13  E-value: 7.78e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564392095 404 RGFAKNMKLEAVNPKNPGEVCVATVISVRGSLLWLRLEGVETpMPEIIVDIDSMDIFPVGWCEANSYPLTTP 475
Cdd:cd20102    2 HGFRVGMKLEAVDRKNPSLICVATVTDVIGNRFLVHFDGWDD-SYDYWCDPDSPYIHPVGWCEENGKTLQPP 72
MBT_L3MBTL1_rpt1 cd20131
first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
69-172 8.28e-17

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage and may bind methylated lysine residues.


Pssm-ID: 439121  Cd Length: 109  Bit Score: 76.84  E-value: 8.28e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095  69 IQSNFQPGMKLEVANKNHPDTYWVATIITTCGQLLLLRYCGYGEDRraDFWCDVIIADLHPVGWCTQNNKVLRPPDAIKE 148
Cdd:cd20131   10 NKNGFKLGMKLEGIDPQHPSMYFILTVAEVCGYRLRLHFDGYSECH--DFWVNANSPDIHPAGWFEKTGHKLQPPKGYKE 87
                         90       100
                 ....*....|....*....|....
gi 564392095 149 KYADWEEFLihELTGSRTAPASLL 172
Cdd:cd20131   88 EEFSWSQYL--RSTRAQAAPKHLF 109
MBT_dSfmbt-like_rpt4 cd20100
fourth malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb ...
404-475 1.70e-16

fourth malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439090  Cd Length: 71  Bit Score: 74.63  E-value: 1.70e-16
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564392095 404 RGFAKNMKLEAVNPKNPGEVCVATVISVRGSLLWLRLEGVETPMPEIiVDIDSMDIFPVGWCEANSYPLTTP 475
Cdd:cd20100    1 HGFKVGMKLEAVDLMEPRLICVATVTRVVGRLLRVHFDGWDDEFDQW-VDCDSPDIYPVGWCELVGYPLQPP 71
MBT_L3MBTL1-like_rpt1 cd20101
first malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like ...
405-475 3.44e-16

first malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage and may bind methylated lysine residues.


Pssm-ID: 439091  Cd Length: 101  Bit Score: 75.00  E-value: 3.44e-16
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564392095 405 GFAKNMKLEAVNPKNPGEVCVATVISVRGSLLWLRLEGVETpMPEIIVDIDSMDIFPVGWCEANSYPLTTP 475
Cdd:cd20101    5 GFKVGMKLEGIDPKHPSLFCVLSVAEVRGYRLRLHFDGYSE-CYDFWVNADSPDIFPVGWCEKTGHKLQPP 74
MBT_dSfmbt_rpt3 cd20125
third malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein ...
299-398 4.64e-16

third malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439115  Cd Length: 107  Bit Score: 74.50  E-value: 4.64e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095 299 FTVGMRLETLhinDPF---HIYPATVTKVFNSQFFQVAIDDLRAETNGLTMLC-HADSLGILPVQWCLKNGVNLAPPKGY 374
Cdd:cd20125    1 FKEGMKLEAV---DPLnlsAICVATVMKVLRFGYLMIRIDSYEPDASGSDWFCyHESSPCIFPAGFCEVNNITLTPPNGY 77
                         90       100
                 ....*....|....*....|....
gi 564392095 375 SGQDFNWVDYHKQREAEGAPPYCF 398
Cdd:cd20125   78 DGRTFTWEGYLRQTGATAAPQHLF 101
MBT_SCMH1_rpt1 cd20105
first malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog ...
379-475 6.91e-16

first malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog 1; Sex comb on midleg homolog 1 (SCMH1) is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. It contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439095  Cd Length: 131  Bit Score: 75.03  E-value: 6.91e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095 379 FNWVDYHKQREAEGAPPYCFKNTF---ARGFAKNMKLEAVNPKNPGEVCVATVISVRGSLLWLRLEGVETPmPEIIVDID 455
Cdd:cd20105    2 FSWDKYLKETGAVPAPVHCFKQSYtppVNEFKIGMKLEAQDPRNTTSTCIATVVGLTGARLRLRLDGSDNK-NDFWRLVD 80
                         90       100
                 ....*....|....*....|
gi 564392095 456 SMDIFPVGWCEANSYPLTTP 475
Cdd:cd20105   81 SSEIQPIGNCEKNGGMLQPP 100
MBT_L3MBTL1-like_rpt3 cd20103
third malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like ...
404-475 3.02e-15

third malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.


Pssm-ID: 439093  Cd Length: 73  Bit Score: 71.15  E-value: 3.02e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564392095 404 RGFAKNMKLEAVNPKNPGEVCVATVISVRGSLLWLRLEGvetpMPEII---VDIDSMDIFPVGWCEANSYPLTTP 475
Cdd:cd20103    3 HGFEVGMKLEAVDKRNPRLIRVATVADVEDYRVKLHFDG----WPDIYdfwVDDDSPDIHPPGWCSKTGHPLEPP 73
MBT_L3MBTL4_rpt1 cd20133
first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
69-171 3.94e-15

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439123  Cd Length: 101  Bit Score: 71.75  E-value: 3.94e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095  69 IQSNFQPGMKLEVANKNHPDTYWVATIITTCGQLLLLRYCGYGEdrRADFWCDVIIADLHPVGWCTQNNKVLRPPDAIKE 148
Cdd:cd20133    2 SRNGFKVGMRLEGIDPEHPSLFCVLSVAEVQGYRLRLHFDGYSE--CYDFWVNADSPDIHPVGWCEKTGHKLLPPKGYKD 79
                         90       100
                 ....*....|....*....|...
gi 564392095 149 KYADWEEFLihELTGSRTAPASL 171
Cdd:cd20133   80 GEFNWSSYL--KTCKAQAAPKNL 100
MBT_dScm-like_rpt2 cd20092
second malignant brain tumor (MBT) repeat found in the Polycomb protein sex comb on midleg ...
399-475 5.28e-15

second malignant brain tumor (MBT) repeat found in the Polycomb protein sex comb on midleg family; The Sex comb on midleg (Scm) family of Polycomb proteins includes Drosophila melanogaster Scm protein, as well as two vertebrate homologs of Scm, Polycomb protein sex comb on midleg homolog 1 (SCMH1) and sex comb on midleg-like protein 2 (SCML2). Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Both SCMH1 and SCML2 are components of PRC1, which acts as an E3 ubiquitin ligase both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. Members of this family contain two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439082  Cd Length: 75  Bit Score: 70.46  E-value: 5.28e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564392095 399 KNTFARGfaknMKLEAVNPKNPGEVCVATVISVRGSLLWLRLEGVETpMPEIIVDIDSMDIFPVGWCEANSYPLTTP 475
Cdd:cd20092    3 KNMFKVG----MKLEAVDRKNPQLICPATVGDVDGDEIHISFDGWRG-AFDYWCRYDSRDIFPVGWCKKTGHPLQPP 74
MBT_SFMBT_rpt3 cd20095
third malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein ...
406-475 5.52e-15

third malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439085  Cd Length: 92  Bit Score: 71.13  E-value: 5.52e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564392095 406 FAKNMKLEAVNPKNPGEVCVATVISVRGSLLWL----RLEGVETPMPEIIVDIDSMDIFPVGWCEANSYPLTTP 475
Cdd:cd20095    1 FKVGMKLEALHPKNPSTICPATVTKVFNEYYFLveidDLRPEESEKITFVCHANSPGIFPVGWCAKNGLRLTPP 74
MBT_dScm-like_rpt1 cd20091
first malignant brain tumor (MBT) repeat found in the sex comb on midleg family; The sex comb ...
70-162 1.01e-14

first malignant brain tumor (MBT) repeat found in the sex comb on midleg family; The sex comb on midleg (Scm) family of Polycomb proteins includes Drosophila melanogaster Scm protein, as well as two vertebrate homologs of Scm, sex comb on midleg homolog 1 (SCMH1) and sex comb on midleg-like protein 2 (SCML2). Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Both SCMH1 and SCML2 are components of PRC1, which acts as an E3 ubiquitin ligase both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. Members of this family contain two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439081  Cd Length: 97  Bit Score: 70.41  E-value: 1.01e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095  70 QSNFQPGMKLEVANKNHPDTYWVATIITTCGQLLLLRYcgYGEDRRADFWCDVIIADLHPVGWCTQNNKVLRPPDAIKEK 149
Cdd:cd20091    7 VNEFKVGMKLEAQDPRNLTSTCIATVVGIQGPRLRLRL--DGSDNKNDFWRLVDSSDIHPVGWCEKNGGLLQPPLGFRMN 84
                         90
                 ....*....|...
gi 564392095 150 YADWEEFLIHELT 162
Cdd:cd20091   85 PSSWPMFLQKTLN 97
MBT_MBTD1_rpt3 cd20126
third malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); ...
299-387 2.25e-14

third malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439116  Cd Length: 90  Bit Score: 69.43  E-value: 2.25e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095 299 FTVGMRLETLhinDPFH---IYPATVTKVFNSQFFQVAIDDLRAEtNGLTMLC-HADSLGILPVQWCLKNGVNLAPPKGY 374
Cdd:cd20126    1 FKEGMKLEAI---DPLNlstICVATVRKVLANGYLMIGIDGSEAA-DGSDWFCyHATSPSIFPVGFCEINMIELTPPRGY 76
                         90
                 ....*....|...
gi 564392095 375 SGQdFNWVDYHKQ 387
Cdd:cd20126   77 KKP-FKWFDYLRE 88
MBT_dScm-like_rpt1 cd20091
first malignant brain tumor (MBT) repeat found in the sex comb on midleg family; The sex comb ...
405-475 4.94e-14

first malignant brain tumor (MBT) repeat found in the sex comb on midleg family; The sex comb on midleg (Scm) family of Polycomb proteins includes Drosophila melanogaster Scm protein, as well as two vertebrate homologs of Scm, sex comb on midleg homolog 1 (SCMH1) and sex comb on midleg-like protein 2 (SCML2). Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Both SCMH1 and SCML2 are components of PRC1, which acts as an E3 ubiquitin ligase both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. Members of this family contain two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439081  Cd Length: 97  Bit Score: 68.48  E-value: 4.94e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564392095 405 GFAKNMKLEAVNPKNPGEVCVATVISVRGSLLWLRLEGvetpmpeiiVD--------IDSMDIFPVGWCEANSYPLTTP 475
Cdd:cd20091    9 EFKVGMKLEAQDPRNLTSTCIATVVGIQGPRLRLRLDG---------SDnkndfwrlVDSSDIHPVGWCEKNGGLLQPP 78
MBT_SFMBT_rpt1 cd20093
first malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein ...
405-475 6.64e-14

first malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.


Pssm-ID: 439083  Cd Length: 94  Bit Score: 68.07  E-value: 6.64e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564392095 405 GFAKNMKLEAVNPKNPGEVCVATVISVRGSLLWLRLEGV-ETPMPEIIVDIDSMDIFPVGWCEANSYPLTTP 475
Cdd:cd20093    3 GFKPGMKLEVPNKNNPDTYWVATVVMTCGPLLRLRYVGYeDDRSADFWCDLSSGDVHPIGWCAQNGKPLQPP 74
MBT_L3MBTL1-like_rpt1 cd20101
first malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like ...
294-398 1.08e-13

first malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage and may bind methylated lysine residues.


Pssm-ID: 439091  Cd Length: 101  Bit Score: 67.68  E-value: 1.08e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095 294 LGSHFFTVGMRLETLhinDPFHiypatvtkvfNSQFFQVAIddlrAETNGLTMLCH-------------ADSLGILPVQW 360
Cdd:cd20101    1 FNKNGFKVGMKLEGI---DPKH----------PSLFCVLSV----AEVRGYRLRLHfdgysecydfwvnADSPDIFPVGW 63
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 564392095 361 CLKNGVNLAPPKGYSGQDFNWVDYHKQREAEGAPPYCF 398
Cdd:cd20101   64 CEKTGHKLQPPKGYTSETFSWSAYLKLTKAQAAPKHLF 101
MBT_L3MBTL1-like_rpt3 cd20103
third malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like ...
73-143 1.29e-13

third malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.


Pssm-ID: 439093  Cd Length: 73  Bit Score: 66.53  E-value: 1.29e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564392095  73 FQPGMKLEVANKNHPDTYWVATIITTCGQLLLLRYCGYGEDRraDFWCDVIIADLHPVGWCTQNNKVLRPP 143
Cdd:cd20103    5 FEVGMKLEAVDKRNPRLIRVATVADVEDYRVKLHFDGWPDIY--DFWVDDDSPDIHPPGWCSKTGHPLEPP 73
MBT_L3MBTL1-like_rpt2 cd20102
second malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like ...
296-384 2.00e-13

second malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439092  Cd Length: 90  Bit Score: 66.50  E-value: 2.00e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095 296 SHFFTVGMRLETLHINDPFHIYPATVTKVfNSQFFQVAIDdlrAETNGLTMLCHADSLGILPVQWCLKNGVNLAPPKGYS 375
Cdd:cd20102    1 PHGFRVGMKLEAVDRKNPSLICVATVTDV-IGNRFLVHFD---GWDDSYDYWCDPDSPYIHPVGWCEENGKTLQPPKGYS 76

                 ....*....
gi 564392095 376 GQDFNWVDY 384
Cdd:cd20102   77 PGNFSWDKY 85
MBT_SCML2_rpt1 cd20106
first malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2; Sex comb ...
71-163 5.18e-13

first malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2; Sex comb on midleg-like protein 2 (SCML2) is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. SCML2 contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439096  Cd Length: 98  Bit Score: 65.72  E-value: 5.18e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095  71 SNFQPGMKLEVANKNHPDTYWVATIITTCGQLLLLRYcgYGEDRRADFWCDVIIADLHPVGWCTQNNKVLRPPDAIKEKY 150
Cdd:cd20106    8 NDFKVGMKLEARDPRNATSVCIATVIGITGARLRLRL--DGSDNKNDFWRLVDSSDIQPIGTCEKEGDMLQPPLGFQMNA 85
                         90
                 ....*....|...
gi 564392095 151 ADWEEFLIHELTG 163
Cdd:cd20106   86 SSWPMFLLRTLNG 98
MBT_dSfmbt-like_rpt4 cd20100
fourth malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb ...
72-143 5.51e-13

fourth malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439090  Cd Length: 71  Bit Score: 64.62  E-value: 5.51e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564392095  72 NFQPGMKLEVANKNHPDTYWVATIITTCGQLLLLRYCGYGEDrrADFWCDVIIADLHPVGWCTQNNKVLRPP 143
Cdd:cd20100    2 GFKVGMKLEAVDLMEPRLICVATVTRVVGRLLRVHFDGWDDE--FDQWVDCDSPDIYPVGWCELVGYPLQPP 71
MBT_L3MBTL4_rpt2 cd20136
second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
73-157 7.77e-13

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439126  Cd Length: 92  Bit Score: 65.02  E-value: 7.77e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095  73 FQPGMKLEVANKNHPDTYWVATIITTCGQLLLLRYCGYgeDRRADFWCDVIIADLHPVGWCTQNNKVLRPPDAI--KEKY 150
Cdd:cd20136    5 FQVGMKLEAVDRKNPSLVCVATIADIVEDRLLVHFDNW--DDSYDYWCDVNSPYIQPVGWCQENGRTLVAPQGYpnPEKF 82

                 ....*..
gi 564392095 151 AdWEEFL 157
Cdd:cd20136   83 S-WTEYL 88
MBT_dSfmbt-like_rpt1 cd20097
first malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein ...
202-268 1.12e-12

first malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.


Pssm-ID: 439087  Cd Length: 105  Bit Score: 65.02  E-value: 1.12e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564392095 202 YWIVSVIENVGGRLRLRYVGLEHTESYDRWLFYLDYRLRPIGWCQEKKYRMDPPSELyyLKLPFEWK 268
Cdd:cd20097   27 YWFARIIKVAGYRVLLRYEGYDEDSSHDFWINLCSNEIHPIGYAAENGKILVPPKSI--EDKENDWK 91
SAM_Atherin-like cd09583
SAM domain of Atherin/Atherin-like subfamily; SAM (sterile alpha motif) domain of SAM_Atherin ...
817-882 1.29e-12

SAM domain of Atherin/Atherin-like subfamily; SAM (sterile alpha motif) domain of SAM_Atherin and Atherin-like subfamily proteins is a putative protein-protein and/or protein-lipid interaction domain. In addition to the C-terminal SAM domain, the majority of proteins belonging to this group also have PHD (or Zn finger) domain. As potential members of the polycomb group, these proteins may be involved in regulation of some key regulatory genes during development. Atherin can be recruited by Ruk/CIN85 kinase-binding proteins via its SH3 domains thus participating in the signal transferring kinase cascades. Also, atherin was found associated with low density lipids (LDL) in atherosclerotic lesions in human. It was suggested that atherin plays an essential role in atherogenesis via immobilization of LDL in the arterial wall. SAM domains of atherins are predicted to form polymers. Inhibition of polymer formation could be a potential antiatherosclerotic therapy.


Pssm-ID: 188982  Cd Length: 69  Bit Score: 63.44  E-value: 1.29e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564392095 817 PLEWSVTDVVRFIKLTDCAPLARIFQEQDIDGQALLLLTLPTVQECMELKLGPAIKLCHQIERVKV 882
Cdd:cd09583    1 PSNWSVEDVVQYFKTAGFPEEANAFKEQEIDGKSLLLLTRSDVLTGLSLKLGPALKIYEHVVKLQQ 66
MBT_L3MBTL2_rpt3 cd20127
third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
299-384 1.34e-12

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2); L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439117  Cd Length: 91  Bit Score: 64.46  E-value: 1.34e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095 299 FTVGMRLETLhinDPFH---IYPATVTKVFNSQFFQVAIDDLRAeTNGLTMLC-HADSLGILPVQWCLKNGVNLAPPKGY 374
Cdd:cd20127    1 FEEGMKLEAI---DPLNlgnICVATVCKVLLDGYLMIGIDGGPS-TDGSDWFCyHASSHAIFPVGFCQKNDIELTPPKGY 76
                         90
                 ....*....|
gi 564392095 375 SGQDFNWVDY 384
Cdd:cd20127   77 DAQTFNWENY 86
MBT_dSfmbt-like_rpt3 cd20099
third malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein ...
406-475 1.50e-12

third malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439089 [Multi-domain]  Cd Length: 91  Bit Score: 64.24  E-value: 1.50e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564392095 406 FAKNMKLEAVNPKNPGEVCVATVISV-RGSLLWLRLEGVETPMPE--IIVDIDSMDIFPVGWCEANSYPLTTP 475
Cdd:cd20099    1 FKVGMKLEAVDPLNLSSICVATVRKVlRFGYLVIGIDGPSADDGSdwFCCHASSPFIFPVGFAEKNGIELTPP 73
MBT_L3MBTL4_rpt1 cd20133
first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
299-398 2.20e-12

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439123  Cd Length: 101  Bit Score: 64.04  E-value: 2.20e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095 299 FTVGMRLETLhinDPFHIYPATVTKVFNSQFFQvaiddLRAETNGLT----MLCHADSLGILPVQWCLKNGVNLAPPKGY 374
Cdd:cd20133    6 FKVGMRLEGI---DPEHPSLFCVLSVAEVQGYR-----LRLHFDGYSecydFWVNADSPDIHPVGWCEKTGHKLLPPKGY 77
                         90       100
                 ....*....|....*....|....
gi 564392095 375 SGQDFNWVDYHKQREAEGAPPYCF 398
Cdd:cd20133   78 KDGEFNWSSYLKTCKAQAAPKNLF 101
MBT_SFMBT_rpt4 cd20096
fourth malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein ...
73-143 4.42e-12

fourth malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439086  Cd Length: 73  Bit Score: 62.26  E-value: 4.42e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564392095  73 FQPGMKLEVANKNHPDTYWVATIITTCGQLLLLRYCGYGEDRRaDFWCDVIIADLHPVGWCTQNNKVLRPP 143
Cdd:cd20096    1 FERGMKLEAVNPENPNQICVATITKVVGPLLWLHLDSEKKLSP-NIIVDVESTDIFPVGWCESNGYPLVTP 70
MBT_SFMBT1_rpt2 cd20113
second malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 ...
73-157 5.52e-12

second malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.


Pssm-ID: 439103  Cd Length: 99  Bit Score: 62.90  E-value: 5.52e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095  73 FQPGMKLEVANKNHPDTYWVATIITTCGQLLLLRYCGYGEDRRADFWCDVIIADLHPVGWCTQNNKVLRPPDAIK--EKY 150
Cdd:cd20113    4 IGPGSRLELQDFQDSLVAWIVVVVENIGGRLKLRYEGLEGSDKSDTWLFYLDPFLHQVGWAAQHGYTLQPPAAIRhlKSE 83

                 ....*..
gi 564392095 151 ADWEEFL 157
Cdd:cd20113   84 AEWQEIL 90
SAM_Samd7,11 cd09579
SAM domain of Samd7,11 subfamily of Polycomb group; SAM (sterile alpha motif) domain is a ...
818-879 5.54e-12

SAM domain of Samd7,11 subfamily of Polycomb group; SAM (sterile alpha motif) domain is a protein-protein interaction domain. Phylogenetic analysis suggests that proteins of this subfamily are most closely related to SAM-Ph1,2,3 subfamily of Polycomb group. They are predicted transcriptional repressors in photoreceptor cells and pinealocytes of vertebrates. SAM domain containing protein 11 is also known as Mr-s (major retinal SAM) protein. In mouse, it is predominantly expressed in developing retinal photoreceptors and in adult pineal gland. The SAM domain is involved in homooligomerization of whole proteins (it was shown based on immunoprecipitation assay and mutagenesis), however its repression activity is not due to SAM/SAM interactions but to the C-terminal region.


Pssm-ID: 188978  Cd Length: 68  Bit Score: 61.70  E-value: 5.54e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564392095 818 LEWSVTDVVRFI-KLTDCAPLARIFQEQDIDGQALLLLTLPTVQECMELKLGPAIKLCHQIER 879
Cdd:cd09579    2 RKWTVDDVCSFIgSLPGCAEYAQVFREHSIDGETLPLLTEEHLLNTMGLKLGPALKIRSQVAK 64
MBT_L3MBTL3_rpt3 cd20138
third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
398-475 6.53e-12

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.


Pssm-ID: 439128  Cd Length: 78  Bit Score: 61.87  E-value: 6.53e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564392095 398 FKNTFARGFAKNMKLEAVNPKNPGEVCVATVISVRGSLLWLRLEGVETPMpEIIVDIDSMDIFPVGWCEANSYPLTTP 475
Cdd:cd20138    1 FKVKPPHGFQKNMKLEVVDKRNPMLIRVATVADTDDHRVKVHFDGWNNCY-DYWIDADSPDIHPAGWCAKTGHPLQPP 77
SAM_Scm-like-4MBT cd09580
SAM domain of Scm-like-4MBT proteins of Polycomb group; SAM (sterile alpha motif) domain of ...
817-881 7.71e-12

SAM domain of Scm-like-4MBT proteins of Polycomb group; SAM (sterile alpha motif) domain of Scm-like-4MBT (Sex comb on midleg like, Malignant Brain Tumor) subfamily proteins of the polycomb group is a putative protein-protein interaction domain. Additionally to the SAM domain, most of the proteins of this subfamily have 4 MBT repeats. In Drosophila SAM-Scm-like-4MBT protein (known as dSfmbt) is a member of Pho repressive complex (PhoRC). Additionally to dSfmbt, the PhoRC complex includes Pho or Pho-like proteins. This complex is responsible for HOX (Homeobox) gene silencing: Pho or Pho-like proteins bind DNA and dSmbt binds methylated histones. dSmbt can interact with mono- and di-methylated histones H3 and H4 (however this activity has been shown for the MBT repeats, while exact function of the SAM domain is unclear). Besides interaction with histones, dSmbt can interact with Scm (a member of PRC complex), but this interaction also seems to be SAM domain independent.


Pssm-ID: 188979  Cd Length: 67  Bit Score: 61.23  E-value: 7.71e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564392095 817 PLEWSVTDVVRFIKLTDCAPLARIFQEQDIDGQALLLLTLPTVQECMELKLGPAIKLCHQIERVK 881
Cdd:cd09580    1 PSTWGVKDVSQFLRENDCGAYCECFCRQNIDGKRLLSLTKEQIMTLTGMKVGPSLKIYDLIQQLK 65
MBT_L3MBTL3_rpt2 cd20135
second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
71-157 9.14e-12

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439125  Cd Length: 93  Bit Score: 62.13  E-value: 9.14e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095  71 SNFQPGMKLEVANKNHPDTYWVATIITTCGQLLLLRYCGYgeDRRADFWCDVIIADLHPVGWCTQNNKVLRPPDAIKE-K 149
Cdd:cd20135    4 SGFRVGMKLEAVDKKNPSFICVATITDMVDNRLLIHFDNW--DESYDYWCDASSPYIHPVGYCQEHGRTLTTPPGYKDpK 81

                 ....*...
gi 564392095 150 YADWEEFL 157
Cdd:cd20135   82 HFSWEKYL 89
MBT_L3MBTL1_rpt3 cd20137
third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
405-475 1.45e-11

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.


Pssm-ID: 439127  Cd Length: 75  Bit Score: 60.99  E-value: 1.45e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564392095 405 GFAKNMKLEAVNPKNPGEVCVATVISVRGSLLWLRLEGvETPMPEIIVDIDSMDIFPVGWCEANSYPLTTP 475
Cdd:cd20137    4 GFQVNMKLEAVDRRNPALIRVASVEDVEDHRIKIHFDG-WSHGYDFWIDADHPDIHPAGWCSKTGHPLQPP 73
MBT_L3MBTL3_rpt3 cd20138
third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
73-143 1.84e-11

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.


Pssm-ID: 439128  Cd Length: 78  Bit Score: 60.71  E-value: 1.84e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564392095  73 FQPGMKLEVANKNHPDTYWVATIITTCGQLLLLRYCGYGEDRraDFWCDVIIADLHPVGWCTQNNKVLRPP 143
Cdd:cd20138    9 FQKNMKLEVVDKRNPMLIRVATVADTDDHRVKVHFDGWNNCY--DYWIDADSPDIHPAGWCAKTGHPLQPP 77
SAM_Scm-like-3MBT3,4 cd09582
SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group; SAM (sterile alpha motif) domain of ...
817-881 1.84e-11

SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group; SAM (sterile alpha motif) domain of Scm-like-3MBT3,4 (Sex comb on midleg, Malignant brain tumor) subfamily proteins (also known as L3mbtl3,4 proteins) is a putative protein-protein interaction domain. Proteins of this subfamily are predicted transcriptional regulators belonging to Polycomb group. The majority of them are multidomain proteins: in addition to the C-terminal SAM domain, they contain three MBT repeats and Zn finger domain. Murine L3mbtl3 protein of this subfamily is essential for maturation of myeloid progenitor cells during differentiation. Human L3mbtl4 is a potential tumor suppressor gene in breast cancer, while deregulation of L3MBTL3 is associated with neuroblastoma.


Pssm-ID: 188981  Cd Length: 66  Bit Score: 60.37  E-value: 1.84e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564392095 817 PLEWSVTDVVRFIK-LTDCAPLARIFQEQDIDGQALLLLTLPTVQECMELKLGPAIKLCHQIERVK 881
Cdd:cd09582    1 VLRWSVDEVAEFVQsLPGCEEHAKVFRDEQIDGEAFLLLTQSDLVKILGIKLGPALKIYNSILMLR 66
MBT_L3MBTL1_rpt1 cd20131
first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
299-398 2.52e-11

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage and may bind methylated lysine residues.


Pssm-ID: 439121  Cd Length: 109  Bit Score: 61.43  E-value: 2.52e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095 299 FTVGMRLETLHINDPFHIYPATVTKVFNSQffqvaiddLRAETNGLTMlCH-----ADSLGILPVQWCLKNGVNLAPPKG 373
Cdd:cd20131   14 FKLGMKLEGIDPQHPSMYFILTVAEVCGYR--------LRLHFDGYSE-CHdfwvnANSPDIHPAGWFEKTGHKLQPPKG 84
                         90       100
                 ....*....|....*....|....*
gi 564392095 374 YSGQDFNWVDYHKQREAEGAPPYCF 398
Cdd:cd20131   85 YKEEEFSWSQYLRSTRAQAAPKHLF 109
MBT cd20088
malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes ...
299-361 3.05e-11

malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes methylated lysine residues on histones and are thought to affect a variety of chromatin processes, including transcription. It exists as tandem repeats and is found in a number of nuclear proteins such as Drosophila sex comb on midleg protein. In the human genome, there are at least 9 MBT repeat proteins, each containing two, three or four MBT repeats. MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine (monomethyllysine and/or dimethyllysine).


Pssm-ID: 439080  Cd Length: 61  Bit Score: 59.58  E-value: 3.05e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564392095 299 FTVGMRLETLHINDPFHIYPATVTKVFNsQFFQVAIDDLraETNGLTMLCHADSLGILPVQWC 361
Cdd:cd20088    1 FKVGMKLEAVDPLNPSEICVATVVKVVG-GRLLLHFDGW--DPSRYDFWCDVDSPDIHPVGWC 60
MBT_MBTD1_rpt4 cd20129
fourth malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); ...
405-475 3.14e-11

fourth malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439119  Cd Length: 71  Bit Score: 59.61  E-value: 3.14e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564392095 405 GFAKNMKLEAVNPKNPGEVCVATVISVRGSLLWLRLEGVETPMPEIiVDIDSMDIFPVGWCEANSYPLTTP 475
Cdd:cd20129    2 GFRVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDEYDQW-VDCESPDLYPVGWCQLTGYQLQPP 71
MBT_dSfmbt-like_rpt2 cd20098
second malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb ...
65-135 4.02e-11

second malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439088  Cd Length: 83  Bit Score: 59.95  E-value: 4.02e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564392095  65 VEISIQSN-FQPGMKLEVANKNHPDTYWVATIITTCGQLLLLRYCGyGEDRRADFWCDVIIADLHPVGWCTQ 135
Cdd:cd20098    6 VLESLKSTpFKVGMRLEVVDKMCISRTRVAVVEEVVGGRLRLQYVD-SEDDDDDFWCHMKSPLIHPVGWSQA 76
MBT_dScm_rpt2 cd20110
second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein ...
405-475 4.27e-11

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein sex comb on midleg (Scm) and similar proteins; Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Scm contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439100  Cd Length: 75  Bit Score: 59.39  E-value: 4.27e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564392095 405 GFAKNMKLEAVNPKNPGEVCVATVISVRGSLLWLRLEGVETPMpEIIVDIDSMDIFPVGWCEANSYPLTTP 475
Cdd:cd20110    5 LFKVGMKLEAVDRKNPHLICPATVGAVKDDQIFVTFDGWRGAF-DYWCRYDSRDIFPVGWCARSGHPLQPP 74
MBT_L3MBTL3_rpt1 cd20132
first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
299-398 5.25e-11

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439122  Cd Length: 101  Bit Score: 59.94  E-value: 5.25e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095 299 FTVGMRLETLhinDPFH--IYPA-TVTKVFNSQFfQVAIDDLraeTNGLTMLCHADSLGILPVQWCLKNGVNLAPPKGYS 375
Cdd:cd20132    6 FKVGMKLEGV---DPEHqsMYCVlTVAEVCGYRI-RLHFDGY---SDCYDFWVNADSPDIHPVGWCEKTGHKLHPPKGYK 78
                         90       100
                 ....*....|....*....|...
gi 564392095 376 GQDFNWVDYHKQREAEGAPPYCF 398
Cdd:cd20132   79 EEEFNWQSYLKTCKAQAAPKSLF 101
MBT_L3MBTL4_rpt3 cd20139
fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
398-475 7.74e-11

fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.


Pssm-ID: 439129  Cd Length: 82  Bit Score: 59.11  E-value: 7.74e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564392095 398 FKNTFARGFAKNMKLEAVNPKNPGEVCVATVISVRGSLLWLRLEGVETPMpEIIVDIDSMDIFPVGWCEANSYPLTTP 475
Cdd:cd20139    1 FKLRPPHGFQVNMKLEAVDKRNPILIRVATIVDKDDHRIKLHFDGWDHNY-DFWVDADSPDIHPVGWCDKTGHALQVP 77
MBT_SCML2_rpt1 cd20106
first malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2; Sex comb ...
406-475 8.87e-11

first malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2; Sex comb on midleg-like protein 2 (SCML2) is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. SCML2 contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439096  Cd Length: 98  Bit Score: 59.17  E-value: 8.87e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095 406 FAKNMKLEAVNPKNPGEVCVATVISVRGSLLWLRLEGVETPmPEIIVDIDSMDIFPVGWCEANSYPLTTP 475
Cdd:cd20106   10 FKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNK-NDFWRLVDSSDIQPIGTCEKEGDMLQPP 78
MBT_dSfmbt_rpt2 cd20122
second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein ...
62-134 1.83e-10

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439112  Cd Length: 83  Bit Score: 57.93  E-value: 1.83e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564392095  62 FRHVEISIQSNFQPGMKLEVANKNHPDTYWVATIITTCGQLLLLRYCGYGEDrRADFWCDVIIADLHPVGWCT 134
Cdd:cd20122    3 HNKVNESLRSRFRLGLNLECVDKNRISQVRVATVTKIVGKRLHLRYEGSEPD-DDGFWCHEDSPLIHPVGWAQ 74
MBT_L3MBTL4_rpt3 cd20139
fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
73-143 2.86e-10

fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.


Pssm-ID: 439129  Cd Length: 82  Bit Score: 57.18  E-value: 2.86e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564392095  73 FQPGMKLEVANKNHPDTYWVATIITTCGQLLLLRYCGYgeDRRADFWCDVIIADLHPVGWCTQNNKVLRPP 143
Cdd:cd20139    9 FQVNMKLEAVDKRNPILIRVATIVDKDDHRIKLHFDGW--DHNYDFWVDADSPDIHPVGWCDKTGHALQVP 77
MBT_dScm_rpt1 cd20107
first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein sex ...
70-161 3.07e-10

first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein sex comb on midleg and similar proteins; Sex comb on midleg (Scm) is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Scm contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439097  Cd Length: 99  Bit Score: 58.01  E-value: 3.07e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095  70 QSNFQPGMKLEVANKNHPDTYWVATIITTCGQLLLLRYcgYGEDRRADFWCDVIIADLHPVGWCTQNNKVLRPPDAIKEK 149
Cdd:cd20107    7 KNEFKIGMKLEALDPRNVTSTCIATVVGVLGPRLRLRL--DGSDNKNDFWRLVDSTEIHPIGHCEKNGGMLQPPLGFRMN 84
                         90
                 ....*....|..
gi 564392095 150 YADWEEFLIHEL 161
Cdd:cd20107   85 ASSWPMFLLKTL 96
MBT_L3MBTL4_rpt1 cd20133
first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
405-475 3.45e-10

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439123  Cd Length: 101  Bit Score: 57.88  E-value: 3.45e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564392095 405 GFAKNMKLEAVNPKNPGEVCVATVISVRGSLLWLRLEGvetpMPEII---VDIDSMDIFPVGWCEANSYPLTTP 475
Cdd:cd20133    5 GFKVGMRLEGIDPEHPSLFCVLSVAEVQGYRLRLHFDG----YSECYdfwVNADSPDIHPVGWCEKTGHKLLPP 74
MBT_dScm_rpt1 cd20107
first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein sex ...
405-475 4.00e-10

first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein sex comb on midleg and similar proteins; Sex comb on midleg (Scm) is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Scm contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439097  Cd Length: 99  Bit Score: 57.63  E-value: 4.00e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564392095 405 GFAKNMKLEAVNPKNPGEVCVATVISVRGSLLWLRLEGVETpMPEIIVDIDSMDIFPVGWCEANSYPLTTP 475
Cdd:cd20107    9 EFKIGMKLEALDPRNVTSTCIATVVGVLGPRLRLRLDGSDN-KNDFWRLVDSTEIHPIGHCEKNGGMLQPP 78
MBT_L3MBTL2_rpt4 cd20130
fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
405-475 4.40e-10

fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2); L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439120  Cd Length: 75  Bit Score: 56.54  E-value: 4.40e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564392095 405 GFAKNMKLEAVNPKNPGEVCVATVISVRGSLLWLRLEGVETPMPEIiVDIDSMDIFPVGWCEANSYPLTTP 475
Cdd:cd20130    5 GFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDSEYDQW-VDCESPDIYPVGWCELTGYQLQPP 74
MBT_SCMH1_rpt2 cd20108
second malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog ...
406-475 5.63e-10

second malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog 1 (SCMH1) and similar proteins; SCMH1 is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. It contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439098  Cd Length: 75  Bit Score: 56.49  E-value: 5.63e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095 406 FAKNMKLEAVNPKNPGEVCVATVISVRGSLLWLRLEGVETPMpEIIVDIDSMDIFPVGWCEANSYPLTTP 475
Cdd:cd20108    6 FKTGMKLEAVDRKNPHFICPATIGEVRGSEVLVTFDGWRGAF-DYWCRYDSRDIFPVGWCSLTGDNLQPP 74
MBT_L3MBTL3_rpt1 cd20132
first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
405-475 6.41e-10

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439122  Cd Length: 101  Bit Score: 56.85  E-value: 6.41e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564392095 405 GFAKNMKLEAVNPKNPGEVCVATVISVRGSLLWLRLEGVeTPMPEIIVDIDSMDIFPVGWCEANSYPLTTP 475
Cdd:cd20132    5 GFKVGMKLEGVDPEHQSMYCVLTVAEVCGYRIRLHFDGY-SDCYDFWVNADSPDIHPVGWCEKTGHKLHPP 74
MBT_dScm_rpt2 cd20110
second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein ...
296-371 7.85e-10

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein sex comb on midleg (Scm) and similar proteins; Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Scm contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439100  Cd Length: 75  Bit Score: 55.92  E-value: 7.85e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564392095 296 SHFFTVGMRLETLHINDPFHIYPATVTKVFNSQFFqVAIDDLRAetnGLTMLCHADSLGILPVQWCLKNGVNLAPP 371
Cdd:cd20110    3 SNLFKVGMKLEAVDRKNPHLICPATVGAVKDDQIF-VTFDGWRG---AFDYWCRYDSRDIFPVGWCARSGHPLQPP 74
MBT_dScm-like_rpt2 cd20092
second malignant brain tumor (MBT) repeat found in the Polycomb protein sex comb on midleg ...
70-143 1.02e-09

second malignant brain tumor (MBT) repeat found in the Polycomb protein sex comb on midleg family; The Sex comb on midleg (Scm) family of Polycomb proteins includes Drosophila melanogaster Scm protein, as well as two vertebrate homologs of Scm, Polycomb protein sex comb on midleg homolog 1 (SCMH1) and sex comb on midleg-like protein 2 (SCML2). Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Both SCMH1 and SCML2 are components of PRC1, which acts as an E3 ubiquitin ligase both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. Members of this family contain two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439082  Cd Length: 75  Bit Score: 55.44  E-value: 1.02e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564392095  70 QSNFQPGMKLEVANKNHPDTYWVATIITTCGQLLLLRYCGYgedRRA-DFWCDVIIADLHPVGWCTQNNKVLRPP 143
Cdd:cd20092    3 KNMFKVGMKLEAVDRKNPQLICPATVGDVDGDEIHISFDGW---RGAfDYWCRYDSRDIFPVGWCKKTGHPLQPP 74
MBT_L3MBTL1_rpt2 cd20134
second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
68-157 1.09e-09

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439124  Cd Length: 93  Bit Score: 56.00  E-value: 1.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095  68 SIQSNFQPGMKLEVANKNHPDTYWVATIITTCGQLLLLRYCGYgeDRRADFWCDVIIADLHPVGWCTQNNKVLRPPdaik 147
Cdd:cd20134    1 PPPLGFQVGMKLEAVDRMNPSLVCVASVTDVVDSRFLVHFDNW--DDTYDYWCDPSSPYIHPVGWCQKQGKPLTPP---- 74
                         90
                 ....*....|....*
gi 564392095 148 EKYAD-----WEEFL 157
Cdd:cd20134   75 QDYPDpdnfsWEKYL 89
MBT_L3MBTL4_rpt2 cd20136
second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
404-475 2.01e-09

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439126  Cd Length: 92  Bit Score: 55.39  E-value: 2.01e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564392095 404 RGFAKNMKLEAVNPKNPGEVCVATVISVRGSLLWLRLEGVETPMpEIIVDIDSMDIFPVGWCEANSYPLTTP 475
Cdd:cd20136    3 KEFQVGMKLEAVDRKNPSLVCVATIADIVEDRLLVHFDNWDDSY-DYWCDVNSPYIQPVGWCQENGRTLVAP 73
MBT_MBTD1_rpt3 cd20126
third malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); ...
406-475 2.74e-09

third malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439116  Cd Length: 90  Bit Score: 54.79  E-value: 2.74e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095 406 FAKNMKLEAVNPKNPGEVCVATVISV-RGSLLWLRLEGVETPmpeiivdiDSMD----------IFPVGWCEANSYPLTT 474
Cdd:cd20126    1 FKEGMKLEAIDPLNLSTICVATVRKVlANGYLMIGIDGSEAA--------DGSDwfcyhatspsIFPVGFCEINMIELTP 72

                 .
gi 564392095 475 P 475
Cdd:cd20126   73 P 73
MBT_SFMBT1_rpt1 cd20111
first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 ...
405-475 2.87e-09

first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.


Pssm-ID: 439101  Cd Length: 94  Bit Score: 54.83  E-value: 2.87e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564392095 405 GFAKNMKLEAVNPKNPGEVCVATVISVRGSLLWLRLEGV-ETPMPEIIVDIDSMDIFPVGWCEANSYPLTTP 475
Cdd:cd20111    3 GFSPGMKLEVAVRTDPNTYWVATIITTCGQLLLLRYDGYgEDRRADFWCDIMTADLHPIGWCEQNGKTLRPP 74
MBT_L3MBTL3_rpt2 cd20135
second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
405-475 4.21e-09

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439125  Cd Length: 93  Bit Score: 54.42  E-value: 4.21e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564392095 405 GFAKNMKLEAVNPKNPGEVCVATVISVRGSLLWLRLEGVETPMpEIIVDIDSMDIFPVGWCEANSYPLTTP 475
Cdd:cd20135    5 GFRVGMKLEAVDKKNPSFICVATITDMVDNRLLIHFDNWDESY-DYWCDASSPYIHPVGYCQEHGRTLTTP 74
MBT_SFMBT2_rpt1 cd20112
first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 ...
406-475 4.96e-09

first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.


Pssm-ID: 439102  Cd Length: 94  Bit Score: 54.22  E-value: 4.96e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564392095 406 FAKNMKLEAVNPKNPGEVCVATVISVRGSLLWLRLEGV-ETPMPEIIVDIDSMDIFPVGWCEANSYPLTTP 475
Cdd:cd20112    4 FQPGMKLEVANKSNPDTYWVATIITTCGQLLLLRYCGYgDDRRADFWCDVMTADLHPVGWCTQNNKVLMPP 74
MBT_L3MBTL1_rpt2 cd20134
second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
405-475 1.03e-08

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439124  Cd Length: 93  Bit Score: 53.30  E-value: 1.03e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564392095 405 GFAKNMKLEAVNPKNPGEVCVATVISVRGSLLWLRLEGVETPMpEIIVDIDSMDIFPVGWCEANSYPLTTP 475
Cdd:cd20134    5 GFQVGMKLEAVDRMNPSLVCVASVTDVVDSRFLVHFDNWDDTY-DYWCDPSSPYIHPVGWCQKQGKPLTPP 74
MBT_dScm-like_rpt2 cd20092
second malignant brain tumor (MBT) repeat found in the Polycomb protein sex comb on midleg ...
298-372 1.59e-08

second malignant brain tumor (MBT) repeat found in the Polycomb protein sex comb on midleg family; The Sex comb on midleg (Scm) family of Polycomb proteins includes Drosophila melanogaster Scm protein, as well as two vertebrate homologs of Scm, Polycomb protein sex comb on midleg homolog 1 (SCMH1) and sex comb on midleg-like protein 2 (SCML2). Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Both SCMH1 and SCML2 are components of PRC1, which acts as an E3 ubiquitin ligase both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. Members of this family contain two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439082  Cd Length: 75  Bit Score: 51.97  E-value: 1.59e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564392095 298 FFTVGMRLETLHINDPFHIYPATVTKVFNSQFFqVAIDDLRaetNGLTMLCHADSLGILPVQWCLKNGVNLAPPK 372
Cdd:cd20092    5 MFKVGMKLEAVDRKNPQLICPATVGDVDGDEIH-ISFDGWR---GAFDYWCRYDSRDIFPVGWCKKTGHPLQPPG 75
MBT_SCML2_rpt2 cd20109
second malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2 (SCML2) ...
406-475 1.95e-08

second malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2 (SCML2) and similar proteins; SCML2 is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. SCML2 contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439099  Cd Length: 77  Bit Score: 52.19  E-value: 1.95e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095 406 FAKNMKLEAVNPKNPGEVCVATVISVRGSLLWLRLEGVETPMpEIIVDIDSMDIFPVGWCEANSYPLTTP 475
Cdd:cd20109    6 FKVGMKLEAIDKKNPYLICPATIGDVKGDEVFITFDGWRGAF-DYWCKYDSRDIFPVGWCRLTGDVLQPP 74
MBT_SCMH1_rpt2 cd20108
second malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog ...
297-371 2.20e-08

second malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog 1 (SCMH1) and similar proteins; SCMH1 is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. It contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439098  Cd Length: 75  Bit Score: 51.87  E-value: 2.20e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564392095 297 HFFTVGMRLETLHINDPFHIYPATVTKVFNSQFFqVAIDDLRAetnGLTMLCHADSLGILPVQWCLKNGVNLAPP 371
Cdd:cd20108    4 NFFKTGMKLEAVDRKNPHFICPATIGEVRGSEVL-VTFDGWRG---AFDYWCRYDSRDIFPVGWCSLTGDNLQPP 74
MBT_L3MBTL1_rpt3 cd20137
third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
73-143 4.98e-08

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.


Pssm-ID: 439127  Cd Length: 75  Bit Score: 50.59  E-value: 4.98e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564392095  73 FQPGMKLEVANKNHPDTYWVATIITTCGQLLLLRYCGYGEDRraDFWCDVIIADLHPVGWCTQNNKVLRPP 143
Cdd:cd20137    5 FQVNMKLEAVDRRNPALIRVASVEDVEDHRIKIHFDGWSHGY--DFWIDADHPDIHPAGWCSKTGHPLQPP 73
MBT_SCML2_rpt2 cd20109
second malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2 (SCML2) ...
70-143 5.04e-08

second malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2 (SCML2) and similar proteins; SCML2 is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. SCML2 contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439099  Cd Length: 77  Bit Score: 50.65  E-value: 5.04e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564392095  70 QSNFQPGMKLEVANKNHPDTYWVATIITTCGQLLLLRYCGYgedRRA-DFWCDVIIADLHPVGWCTQNNKVLRPP 143
Cdd:cd20109    3 LNNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVFITFDGW---RGAfDYWCKYDSRDIFPVGWCRLTGDVLQPP 74
MBT_SCMH1_rpt2 cd20108
second malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog ...
70-143 7.06e-08

second malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog 1 (SCMH1) and similar proteins; SCMH1 is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. It contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439098  Cd Length: 75  Bit Score: 50.33  E-value: 7.06e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564392095  70 QSNFQPGMKLEVANKNHPDTYWVATIITTCGQLLLLRYCGYgedRRA-DFWCDVIIADLHPVGWCTQNNKVLRPP 143
Cdd:cd20108    3 QNFFKTGMKLEAVDRKNPHFICPATIGEVRGSEVLVTFDGW---RGAfDYWCRYDSRDIFPVGWCSLTGDNLQPP 74
MBT_L3MBTL4_rpt2 cd20136
second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
299-384 8.76e-08

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439126  Cd Length: 92  Bit Score: 50.77  E-value: 8.76e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095 299 FTVGMRLETLHINDPFHIYPATVTKVFNSQFFqVAIDDLraeTNGLTMLCHADSLGILPVQWCLKNGVNLAPPKGYSGQD 378
Cdd:cd20136    5 FQVGMKLEAVDRKNPSLVCVATIADIVEDRLL-VHFDNW---DDSYDYWCDVNSPYIQPVGWCQENGRTLVAPQGYPNPE 80

                 ....*..
gi 564392095 379 -FNWVDY 384
Cdd:cd20136   81 kFSWTEY 87
MBT_L3MBTL2_rpt4 cd20130
fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
73-143 9.07e-08

fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2); L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439120  Cd Length: 75  Bit Score: 49.99  E-value: 9.07e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564392095  73 FQPGMKLEVANKNHPDTYWVATIITTCGQLLLLRYCGYgeDRRADFWCDVIIADLHPVGWCTQNNKVLRPP 143
Cdd:cd20130    6 FKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGW--DSEYDQWVDCESPDIYPVGWCELTGYQLQPP 74
MBT_dSfmbt_rpt4 cd20128
fourth malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein ...
73-143 1.04e-07

fourth malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt); dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439118  Cd Length: 72  Bit Score: 49.65  E-value: 1.04e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564392095  73 FQPGMKLEVANKNHPDTYWVATIITTCGQLLLLRYCGYGEDRraDFWCDVIIADLHPVGWCTQ-NNKVLRPP 143
Cdd:cd20128    3 FEVGMSLECADLMDPRLVCVATVARVVGRLLKVHFDGWTDEY--DQWLDCESADIYPVGWCVLvNHKLEGPP 72
MBT_dSfmbt_rpt3 cd20125
third malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein ...
406-475 1.05e-07

third malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439115  Cd Length: 107  Bit Score: 51.01  E-value: 1.05e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 564392095 406 FAKNMKLEAVNPKNPGEVCVATVISV-RGSLLWLRLEGVE---TPMPEIIVDIDSMDIFPVGWCEANSYPLTTP 475
Cdd:cd20125    1 FKEGMKLEAVDPLNLSAICVATVMKVlRFGYLMIRIDSYEpdaSGSDWFCYHESSPCIFPAGFCEVNNITLTPP 74
MBT_SFMBT2_rpt2 cd20114
second malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 ...
75-157 1.62e-07

second malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.


Pssm-ID: 439104  Cd Length: 98  Bit Score: 50.11  E-value: 1.62e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095  75 PGMKLEVANKNHPDTYWVATIITTCGQLLLLRYCGYgEDRRADFWCDVIIADLHPVGWCTQNNKVLRPPDAIK--EKYAD 152
Cdd:cd20114    6 VGSLIELQDSQNPFQYWIVRVIENVGGRLRLRYVGL-EDESHDQWLFYLDTRLRPVGWCQENNLRMEPPTEICdlKSASE 84

                 ....*
gi 564392095 153 WEEFL 157
Cdd:cd20114   85 WKEAL 89
MBT_dSfmbt_rpt4 cd20128
fourth malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein ...
405-475 1.94e-07

fourth malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt); dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439118  Cd Length: 72  Bit Score: 48.88  E-value: 1.94e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564392095 405 GFAKNMKLEAVNPKNPGEVCVATVISVRGSLLWLRLEGVETPMPEIIvDIDSMDIFPVGWCEANSYPLTTP 475
Cdd:cd20128    2 GFEVGMSLECADLMDPRLVCVATVARVVGRLLKVHFDGWTDEYDQWL-DCESADIYPVGWCVLVNHKLEGP 71
MBT_L3MBTL2_rpt3 cd20127
third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
406-475 1.95e-07

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2); L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439117  Cd Length: 91  Bit Score: 49.44  E-value: 1.95e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564392095 406 FAKNMKLEAVNPKNPGEVCVATVISV-RGSLLWLRLEGVETP--MPEIIVDIDSMDIFPVGWCEANSYPLTTP 475
Cdd:cd20127    1 FEEGMKLEAIDPLNLGNICVATVCKVlLDGYLMIGIDGGPSTdgSDWFCYHASSHAIFPVGFCQKNDIELTPP 73
MBT_L3MBTL1_rpt2 cd20134
second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
299-384 2.14e-07

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439124  Cd Length: 93  Bit Score: 49.45  E-value: 2.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095 299 FTVGMRLETLHINDPFHIYPATVTKVFNSQFFqVAIDDLraeTNGLTMLCHADSLGILPVQWCLKNGVNLAPPKGYSGQD 378
Cdd:cd20134    6 FQVGMKLEAVDRMNPSLVCVASVTDVVDSRFL-VHFDNW---DDTYDYWCDPSSPYIHPVGWCQKQGKPLTPPQDYPDPD 81

                 ....*..
gi 564392095 379 -FNWVDY 384
Cdd:cd20134   82 nFSWEKY 88
MBT_MBTD1_rpt4 cd20129
fourth malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); ...
73-143 2.30e-07

fourth malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439119  Cd Length: 71  Bit Score: 48.82  E-value: 2.30e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564392095  73 FQPGMKLEVANKNHPDTYWVATIITTCGQLLLLRYCGYGEDRraDFWCDVIIADLHPVGWCTQNNKVLRPP 143
Cdd:cd20129    3 FRVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDEY--DQWVDCESPDLYPVGWCQLTGYQLQPP 71
MBT_SCML2_rpt2 cd20109
second malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2 (SCML2) ...
297-371 3.26e-07

second malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2 (SCML2) and similar proteins; SCML2 is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. SCML2 contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439099  Cd Length: 77  Bit Score: 48.73  E-value: 3.26e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564392095 297 HFFTVGMRLETLHINDPFHIYPATVTKVFNSQFFqVAIDDLRAetnGLTMLCHADSLGILPVQWCLKNGVNLAPP 371
Cdd:cd20109    4 NNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVF-ITFDGWRG---AFDYWCKYDSRDIFPVGWCRLTGDVLQPP 74
MBT_L3MBTL1_rpt1 cd20131
first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
405-475 4.33e-07

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage and may bind methylated lysine residues.


Pssm-ID: 439121  Cd Length: 109  Bit Score: 49.11  E-value: 4.33e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564392095 405 GFAKNMKLEAVNPKNPGEVCVATVISVRGSLLWLRLEGVeTPMPEIIVDIDSMDIFPVGWCEANSYPLTTP 475
Cdd:cd20131   13 GFKLGMKLEGIDPQHPSMYFILTVAEVCGYRLRLHFDGY-SECHDFWVNANSPDIHPAGWFEKTGHKLQPP 82
MBT_MBTD1_rpt2 cd20123
second malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); ...
65-132 5.65e-07

second malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439113  Cd Length: 85  Bit Score: 48.03  E-value: 5.65e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564392095  65 VEISIQSNFQPGMKLEVANKNHPDTYWVATIITTCGQLLLLRYcGYGEDRRADFWCDVIIADLHPVGW 132
Cdd:cd20123    6 VSESMQYPFKPCMRVEVVDKTHLCRTRVAVVESVIGGRLRLVY-EESEDGTDDFWCHMYSPLIHHIGW 72
MBT_SFMBT2_rpt4 cd20118
fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 ...
73-143 7.95e-07

fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439108  Cd Length: 91  Bit Score: 47.90  E-value: 7.95e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564392095  73 FQPGMKLEVANKNHPDTYWVATIITTCGQLLLLRYCGYgEDRRADFWCDVIIADLHPVGWCTQNNKVLRPP 143
Cdd:cd20118    2 FTKNMKLEAVNPRNPAEICVASITSVKGRLLWLHLEGL-QNPVPEYIVDVESMDIFPVGWCEANGYPLTPP 71
MBT_SFMBT2_rpt3 cd20116
three malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 ...
406-475 8.25e-07

three malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439106  Cd Length: 93  Bit Score: 47.87  E-value: 8.25e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564392095 406 FAKNMKLEAVNPKNPGEVCVATVISVRGSLLW------LRLEGVETPMpeiIVDIDSMDIFPVGWCEANSYPLTTP 475
Cdd:cd20116    3 FTVGMKLEVVDPREPFHICPASVTKVFNNHYFqvtvddLRPEASENSM---LCHADSLGILPVQWCLKNGVNLTPP 75
MBT_dSfmbt-like_rpt3 cd20099
third malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein ...
73-157 1.18e-06

third malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439089 [Multi-domain]  Cd Length: 91  Bit Score: 47.29  E-value: 1.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095  73 FQPGMKLEVANKNHPDTYWVATIITTCGQ-LLLLRYCGYGEDRRADFWCdvIIAD---LHPVGWCTQNNKVLRPPDAIKE 148
Cdd:cd20099    1 FKVGMKLEAVDPLNLSSICVATVRKVLRFgYLVIGIDGPSADDGSDWFC--CHASspfIFPVGFAEKNGIELTPPRGYES 78

                 ....*....
gi 564392095 149 KYADWEEFL 157
Cdd:cd20099   79 KPFDWEEYL 87
MBT_L3MBTL2_rpt2 cd20124
second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
64-144 2.77e-06

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2); L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439114  Cd Length: 84  Bit Score: 45.99  E-value: 2.77e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095  64 HVEI--SIQSNFQPGMKLEVANKNHPDTYWVATIITTCGQLLLLRYCGYGEDrrADFWCDVIIADLHPVGWCTQNNKVLR 141
Cdd:cd20124    3 HIKMaeSMKYPFRQGMRVEVVDKSQVSRTRMAVVDTVIGGRLRLLYEDGDSD--DDFWCHMWSPLIHPVGWSRRVGHSIK 80

                 ...
gi 564392095 142 PPD 144
Cdd:cd20124   81 MSD 83
SAM smart00454
Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related ...
817-881 2.90e-06

Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylated. In many cases mediates homodimerisation.


Pssm-ID: 197735  Cd Length: 68  Bit Score: 45.36  E-value: 2.90e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564392095   817 PLEWSVTDVVRFIKLTDCAPLARIFQEQDIDGQALLLLtlpTVQECME----LKLGPAIKLCHQIERVK 881
Cdd:smart00454   1 VSQWSPESVADWLESIGLEQYADNFRKNGIDGALLLLL---TSEEDLKelgiTKLGHRKKILKAIQKLK 66
MBT_L3MBTL1_rpt1 cd20131
first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
195-267 4.17e-06

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage and may bind methylated lysine residues.


Pssm-ID: 439121  Cd Length: 109  Bit Score: 46.41  E-value: 4.17e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564392095 195 DSQNPFQYWIVSVIENVGGRLRLRYVGleHTESYDRWLFYLDYRLRPIGWCQEKKYRMDPPSElyYLKLPFEW 267
Cdd:cd20131   24 DPQHPSMYFILTVAEVCGYRLRLHFDG--YSECHDFWVNANSPDIHPAGWFEKTGHKLQPPKG--YKEEEFSW 92
MBT_L3MBTL4_rpt1 cd20133
first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
195-267 4.86e-06

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439123  Cd Length: 101  Bit Score: 45.94  E-value: 4.86e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564392095 195 DSQNPFQYWIVSVIENVGGRLRLRYVGleHTESYDRWLFYLDYRLRPIGWCQEKKYRMDPPSElyYLKLPFEW 267
Cdd:cd20133   16 DPEHPSLFCVLSVAEVQGYRLRLHFDG--YSECYDFWVNADSPDIHPVGWCEKTGHKLLPPKG--YKDGEFNW 84
MBT_L3MBTL2_rpt1 cd20121
first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
202-259 5.18e-06

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2) and similar proteins; L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.


Pssm-ID: 439111  Cd Length: 102  Bit Score: 45.99  E-value: 5.18e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 564392095 202 YWIVSVIENVGGRLRLRYVGLEHTESYDRWLFYLDYRLRPIGWCQEKKYRMDPPSELY 259
Cdd:cd20121   24 YWIASVIQLAGYKALLRYEGFENDSSHDFWCNLGTVDVHPIGWCAINSKILVPPQTIH 81
SAM_1 pfam00536
SAM domain (Sterile alpha motif); It has been suggested that SAM is an evolutionarily ...
819-881 5.24e-06

SAM domain (Sterile alpha motif); It has been suggested that SAM is an evolutionarily conserved protein binding domain that is involved in the regulation of numerous developmental processes in diverse eukaryotes. The SAM domain can potentially function as a protein interaction module through its ability to homo- and heterooligomerise with other SAM domains.


Pssm-ID: 425739  Cd Length: 64  Bit Score: 44.57  E-value: 5.24e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564392095  819 EWSVTDVVRFIKLTDCAPLARIFQEQDIDGQALLLLtlpTVQECMEL---KLGPAIKLCHQIERVK 881
Cdd:pfam00536   2 GWSVEDVGEWLESIGLGQYIDSFRAGYIDGDALLQL---TEDDLLKLgvtLLGHRKKILYAIQRLK 64
SAM_PNT smart00251
SAM / Pointed domain; A subfamily of the SAM domain
805-870 5.66e-06

SAM / Pointed domain; A subfamily of the SAM domain


Pssm-ID: 128547  Cd Length: 82  Bit Score: 45.33  E-value: 5.66e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095   805 QSEEEKLILESNPLEWSVTDVVRFI----KLTDCAPLarIFQEQDIDGQALLLLTlptvQECMELKLGPA 870
Cdd:smart00251   5 EKEQKRLGIPADPQLWTEDHVLEWLewavKEFSLSPI--DFSKFDMSGKELCSMS----KEEFLERAPFG 68
MBT_dScm_rpt2 cd20110
second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein ...
73-143 6.38e-06

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein sex comb on midleg (Scm) and similar proteins; Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Scm contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439100  Cd Length: 75  Bit Score: 44.75  E-value: 6.38e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564392095  73 FQPGMKLEVANKNHPDTYWVATIITTCGQLLLLRYCGYgedRRA-DFWCDVIIADLHPVGWCTQNNKVLRPP 143
Cdd:cd20110    6 FKVGMKLEAVDRKNPHLICPATVGAVKDDQIFVTFDGW---RGAfDYWCRYDSRDIFPVGWCARSGHPLQPP 74
MBT_dSfmbt-like_rpt4 cd20100
fourth malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb ...
297-371 7.76e-06

fourth malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439090  Cd Length: 71  Bit Score: 44.59  E-value: 7.76e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564392095 297 HFFTVGMRLETLHINDPFHIYPATVTKVFNSQffqvaiddLRAETNGLT----MLCHADSLGILPVQWCLKNGVNLAPP 371
Cdd:cd20100    1 HGFKVGMKLEAVDLMEPRLICVATVTRVVGRL--------LRVHFDGWDdefdQWVDCDSPDIYPVGWCELVGYPLQPP 71
MBT_L3MBTL3_rpt2 cd20135
second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
299-384 8.58e-06

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439125  Cd Length: 93  Bit Score: 45.18  E-value: 8.58e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095 299 FTVGMRLETLHINDPFHIYPATVTKVFNSQFFqVAIDDLraeTNGLTMLCHADSLGILPVQWCLKNGVNLAPPKGY-SGQ 377
Cdd:cd20135    6 FRVGMKLEAVDKKNPSFICVATITDMVDNRLL-IHFDNW---DESYDYWCDASSPYIHPVGYCQEHGRTLTTPPGYkDPK 81

                 ....*..
gi 564392095 378 DFNWVDY 384
Cdd:cd20135   82 HFSWEKY 88
MBT_dSfmbt-like_rpt2 cd20098
second malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb ...
406-467 9.11e-06

second malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439088  Cd Length: 83  Bit Score: 44.55  E-value: 9.11e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564392095 406 FAKNMKLEAVNPKNPGEVCVATVISVRGSLLWLRLEGVETPMPEIIVDIDSMDIFPVGWCEA 467
Cdd:cd20098   15 FKVGMRLEVVDKMCISRTRVAVVEEVVGGRLRLQYVDSEDDDDDFWCHMKSPLIHPVGWSQA 76
SAM_superfamily cd09487
SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of ...
824-879 2.43e-05

SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of approximately 70 amino acids. This domain is found in the Fungi/Metazoa group and in a restricted number of bacteria. Proteins with SAM domains are represented by a wide variety of domain architectures and have different intracellular localization, including nucleus, cytoplasm and membranes. SAM domains have diverse functions. They can interact with proteins, RNAs and membrane lipids, contain site of phosphorylation and/or kinase docking site, and play a role in protein homo and hetero dimerization/oligomerization in processes ranging from signal transduction to regulation of transcription. Mutations in SAM domains have been linked to several diseases.


Pssm-ID: 188886 [Multi-domain]  Cd Length: 56  Bit Score: 42.61  E-value: 2.43e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 564392095 824 DVVRFIKLTDCAPLARIFQEQDIDGQALLLLTLPTVQECMELKLGPAIKLCHQIER 879
Cdd:cd09487    1 DVAEWLESLGLEQYADLFRKNEIDGDALLLLTDEDLKELGITSPGHRKKILRAIQR 56
MBT_dSfmbt_rpt1 cd20119
first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein ...
410-475 2.47e-05

first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.


Pssm-ID: 439109  Cd Length: 104  Bit Score: 43.97  E-value: 2.47e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564392095 410 MKLEAVN-----PKNPGEVCVATVISVRGSLLWLRLEGVET-PMPEIIVDIDSMDIFPVGWCEANSYPLTTP 475
Cdd:cd20119    8 MKVEVENtdtdlIEDPTSFWIATVLKIAGYKALMRYEGFGTdDSKDFWVNLCSEDVHPVGWCATRGKPLIPP 79
MBT_L3MBTL3_rpt1 cd20132
first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
195-255 2.77e-05

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439122  Cd Length: 101  Bit Score: 43.76  E-value: 2.77e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564392095 195 DSQNPFQYWIVSVIENVGGRLRLRYVGleHTESYDRWLFYLDYRLRPIGWCQEKKYRMDPP 255
Cdd:cd20132   16 DPEHQSMYCVLTVAEVCGYRIRLHFDG--YSDCYDFWVNADSPDIHPVGWCEKTGHKLHPP 74
MBT_SCMH1_rpt1 cd20105
first malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog ...
153-255 3.99e-05

first malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog 1; Sex comb on midleg homolog 1 (SCMH1) is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. It contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439095  Cd Length: 131  Bit Score: 44.21  E-value: 3.99e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095 153 WEEFLihELTGSRTAPASLLEGPLrgKGPIDLITVDSLIELQDSQNPFQYWIVSVIENVGGRLRLRYVGLEHTEsyDRWL 232
Cdd:cd20105    4 WDKYL--KETGAVPAPVHCFKQSY--TPPVNEFKIGMKLEAQDPRNTTSTCIATVVGLTGARLRLRLDGSDNKN--DFWR 77
                         90       100
                 ....*....|....*....|...
gi 564392095 233 FYLDYRLRPIGWCQEKKYRMDPP 255
Cdd:cd20105   78 LVDSSEIQPIGNCEKNGGMLQPP 100
MBT_dSfmbt-like_rpt1 cd20097
first malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein ...
408-475 6.61e-05

first malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.


Pssm-ID: 439087  Cd Length: 105  Bit Score: 42.68  E-value: 6.61e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564392095 408 KNMKLEAVN---PKNPGEVCV---ATVISVRGSLLWLRLEGVETP-MPEIIVDIDSMDIFPVGWCEANSYPLTTP 475
Cdd:cd20097    6 IGVKVEVANrddDKPTDNVKVywfARIIKVAGYRVLLRYEGYDEDsSHDFWINLCSNEIHPIGYAAENGKILVPP 80
MBT_MBTD1_rpt1 cd20120
first malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); ...
202-255 7.76e-05

first malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.


Pssm-ID: 439110  Cd Length: 103  Bit Score: 42.53  E-value: 7.76e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 564392095 202 YWIVSVIENVGGRLRLRYVGLEHTESYDRWLFYLDYRLRPIGWCQEKKYRMDPP 255
Cdd:cd20120   24 FWIAGIVKLAGYKALLRYEGFENDSSLDFWCNICGSDIHPVGWCATSGKPLVPP 77
MBT_dSfmbt_rpt1 cd20119
first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein ...
183-255 9.84e-05

first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.


Pssm-ID: 439109  Cd Length: 104  Bit Score: 42.43  E-value: 9.84e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564392095 183 DLITVDSLIELQD-----SQNPFQYWIVSVIENVGGRLRLRYVGLEHTESYDRWLFYLDYRLRPIGWCQEKKYRMDPP 255
Cdd:cd20119    2 DNITVGMKVEVENtdtdlIEDPTSFWIATVLKIAGYKALMRYEGFGTDDSKDFWVNLCSEDVHPVGWCATRGKPLIPP 79
MBT_SFMBT1_rpt4 cd20117
fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 ...
297-372 1.11e-04

fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439107  Cd Length: 90  Bit Score: 41.79  E-value: 1.11e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564392095 297 HFFTVGMRLETLHINDPFHIYPATVTKVFNSQFFqvaiddLRAETNGLTM---LCHADSLGILPVQWCLKNGVNLAPPK 372
Cdd:cd20117    1 HCFKENMKLEAVNPICPEEICVATVTKVKGSYLW------LQLEGSKKPIpecIVHVESMDIFPVGWCETNGYPLLHPR 73
MBT_L3MBTL1-like_rpt3 cd20103
third malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like ...
297-371 1.23e-04

third malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.


Pssm-ID: 439093  Cd Length: 73  Bit Score: 41.11  E-value: 1.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095 297 HFFTVGMRLETLHINDPFHIYPATVTKVfnsqffqvaiDDLRaetngltMLCH-------------ADSLGILPVQWCLK 363
Cdd:cd20103    3 HGFEVGMKLEAVDKRNPRLIRVATVADV----------EDYR-------VKLHfdgwpdiydfwvdDDSPDIHPPGWCSK 65

                 ....*...
gi 564392095 364 NGVNLAPP 371
Cdd:cd20103   66 TGHPLEPP 73
SAM_Ste50_fungal cd09536
SAM domain of Ste50 fungal subfamily; SAM (sterile alpha motif) domain of Ste50 fungal ...
815-873 2.81e-04

SAM domain of Ste50 fungal subfamily; SAM (sterile alpha motif) domain of Ste50 fungal subfamily is a protein-protein interaction domain. Proteins of this subfamily have SAM domain at the N-terminus and Ras-associated UBQ superfamily domain at the C-terminus. They participate in regulation of mating pheromone response, invasive growth and high osmolarity growth response, and contribute to cell wall integrity in vegetative cells. Ste50 of S.cerevisiae acts as an adaptor protein between G protein and MAP triple kinase Ste11. Ste50 proteins are able to form homooligomers, binding each other via their SAM domains, as well as heterodimers and heterogeneous complexes with SAM domain or SAM homodimers of MAPKKK Ste11 protein kinase.


Pssm-ID: 188935  Cd Length: 74  Bit Score: 40.11  E-value: 2.81e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564392095 815 SNPLEWSVTDVVRFIK----LTDCAPLARIFQEQDIDGQALLLLTLptvQECMEL---KLGPAIKL 873
Cdd:cd09536    1 EEFNEWSTDEVVKWCIsslgLDDGDPLCDRLRENNITGSLLSELTL---EDCKELcdnDLSLAIRL 63
MBT_SCML2_rpt1 cd20106
first malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2; Sex comb ...
181-255 3.35e-04

first malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2; Sex comb on midleg-like protein 2 (SCML2) is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. SCML2 contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439096  Cd Length: 98  Bit Score: 40.68  E-value: 3.35e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564392095 181 PIDLITVDSLIELQDSQNPFQYWIVSVIENVGGRLRLRYVGLEHTEsyDRWLFYLDYRLRPIGWCQEKKYRMDPP 255
Cdd:cd20106    6 PVNDFKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNKN--DFWRLVDSSDIQPIGTCEKEGDMLQPP 78
MBT_dScm-like_rpt1 cd20091
first malignant brain tumor (MBT) repeat found in the sex comb on midleg family; The sex comb ...
191-267 3.55e-04

first malignant brain tumor (MBT) repeat found in the sex comb on midleg family; The sex comb on midleg (Scm) family of Polycomb proteins includes Drosophila melanogaster Scm protein, as well as two vertebrate homologs of Scm, sex comb on midleg homolog 1 (SCMH1) and sex comb on midleg-like protein 2 (SCML2). Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Both SCMH1 and SCML2 are components of PRC1, which acts as an E3 ubiquitin ligase both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. Members of this family contain two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439081  Cd Length: 97  Bit Score: 40.36  E-value: 3.55e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564392095 191 IELQDSQNPFQYWIVSVIENVGGRLRLRYVGLEHTEsyDRWLFYLDYRLRPIGWCQEKKYRMDPPseLYYLKLPFEW 267
Cdd:cd20091   16 LEAQDPRNLTSTCIATVVGIQGPRLRLRLDGSDNKN--DFWRLVDSSDIHPVGWCEKNGGLLQPP--LGFRMNPSSW 88
MBT_MBTD1_rpt1 cd20120
first malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); ...
407-475 4.39e-04

first malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.


Pssm-ID: 439110  Cd Length: 103  Bit Score: 40.60  E-value: 4.39e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564392095 407 AKNMKLEAVNPKN--PGEV-CVATVISVRGSLLWLRLEGVETPMP-EIIVDIDSMDIFPVGWCEANSYPLTTP 475
Cdd:cd20120    5 AEGVRVEVPNTDCnlPTKVfWIAGIVKLAGYKALLRYEGFENDSSlDFWCNICGSDIHPVGWCATSGKPLVPP 77
MBT_dSfmbt_rpt3 cd20125
third malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein ...
73-174 5.02e-04

third malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439115  Cd Length: 107  Bit Score: 40.22  E-value: 5.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095  73 FQPGMKLEVANKNHPDTYWVATIITTCGQ-LLLLRYCGYGEDRR-ADFWCDVIIAD-LHPVGWCTQNNKVLRPPDAIKEK 149
Cdd:cd20125    1 FKEGMKLEAVDPLNLSAICVATVMKVLRFgYLMIRIDSYEPDASgSDWFCYHESSPcIFPAGFCEVNNITLTPPNGYDGR 80
                         90       100
                 ....*....|....*....|....*
gi 564392095 150 YADWEEFLihELTGSRTAPASLLEG 174
Cdd:cd20125   81 TFTWEGYL--RQTGATAAPQHLFHR 103
MBT_L3MBTL1-like_rpt2 cd20102
second malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like ...
192-268 5.64e-04

second malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439092  Cd Length: 90  Bit Score: 39.53  E-value: 5.64e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564392095 192 ELQDSQNPFQYWIVSVIENVGGRLRLRYVGLehTESYDRWLFYLDYRLRPIGWCQEKKYRMDPPSElyYLKLPFEWK 268
Cdd:cd20102   11 EAVDRKNPSLICVATVTDVIGNRFLVHFDGW--DDSYDYWCDPDSPYIHPVGWCEENGKTLQPPKG--YSPGNFSWD 83
MBT_MBTD1_rpt4 cd20129
fourth malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); ...
191-255 7.98e-04

fourth malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439119  Cd Length: 71  Bit Score: 38.81  E-value: 7.98e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564392095 191 IELQDSQNPFQYWIVSVIENVGGRLRLRYVGLEhtESYDRWLFYLDYRLRPIGWCQEKKYRMDPP 255
Cdd:cd20129    9 LEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWE--DEYDQWVDCESPDLYPVGWCQLTGYQLQPP 71
MBT_dSfmbt-like_rpt4 cd20100
fourth malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb ...
202-255 8.46e-04

fourth malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439090  Cd Length: 71  Bit Score: 38.81  E-value: 8.46e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 564392095 202 YWI-VSVIENVGGRL-RLRYVGLEhtESYDRWLFYLDYRLRPIGWCQEKKYRMDPP 255
Cdd:cd20100   18 RLIcVATVTRVVGRLlRVHFDGWD--DEFDQWVDCDSPDIYPVGWCELVGYPLQPP 71
MBT_SFMBT1_rpt3 cd20115
third malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 ...
406-475 1.10e-03

third malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439105  Cd Length: 94  Bit Score: 39.08  E-value: 1.10e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564392095 406 FAKNMKLEAVNPKNPGEVCVATVISVRGSLLWLRLegVETPMPE------IIVDIDSMDIFPVGWCEANSYPLTTP 475
Cdd:cd20115    3 FSEGMKLEAVDPAAPFTISPATVAKVFNEKFFLVE--MDDLRPEeagahsFVCHRDSPGIFPVQWSLKNGLHLSPP 76
MBT_L3MBTL3_rpt2 cd20135
second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
191-267 1.40e-03

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439125  Cd Length: 93  Bit Score: 38.63  E-value: 1.40e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564392095 191 IELQDSQNPFQYWIVSVIENVGGRLRLRYVGLEhtESYDRWLFYLDYRLRPIGWCQEKKYRMDPPSELYYLKlPFEW 267
Cdd:cd20135   12 LEAVDKKNPSFICVATITDMVDNRLLIHFDNWD--ESYDYWCDASSPYIHPVGYCQEHGRTLTTPPGYKDPK-HFSW 85
MBT_L3MBTL4_rpt2 cd20136
second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
191-255 1.54e-03

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439126  Cd Length: 92  Bit Score: 38.45  E-value: 1.54e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564392095 191 IELQDSQNPFQYWIVSVIENVGGRLRLRYVGLEhtESYDRWLFYLDYRLRPIGWCQEKKYRMDPP 255
Cdd:cd20136   11 LEAVDRKNPSLVCVATIADIVEDRLLVHFDNWD--DSYDYWCDVNSPYIQPVGWCQENGRTLVAP 73
MBT_MBTD1_rpt4 cd20129
fourth malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); ...
297-371 1.59e-03

fourth malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439119  Cd Length: 71  Bit Score: 38.04  E-value: 1.59e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564392095 297 HFFTVGMRLETLHINDPFHIYPATVTKVFNsQFFQVAIDDLRAETNgltMLCHADSLGILPVQWCLKNGVNLAPP 371
Cdd:cd20129    1 HGFRVGMKLEAVDLMEPRLVCVATVTRIIH-RLLRIHFDGWEDEYD---QWVDCESPDLYPVGWCQLTGYQLQPP 71
MBT_dSfmbt-like_rpt2 cd20098
second malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb ...
206-247 1.93e-03

second malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439088  Cd Length: 83  Bit Score: 38.00  E-value: 1.93e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 564392095 206 SVIENVGGRLRLRYVGLEHTESyDRWLFYLDYRLRPIGWCQE 247
Cdd:cd20098   36 VVEEVVGGRLRLQYVDSEDDDD-DFWCHMKSPLIHPVGWSQA 76
MBT_L3MBTL2_rpt1 cd20121
first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
408-475 2.02e-03

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2) and similar proteins; L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.


Pssm-ID: 439111  Cd Length: 102  Bit Score: 38.67  E-value: 2.02e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564392095 408 KNMKLEAVNPKN--PGEV-CVATVISVRGSLLWLRLEGVET-PMPEIIVDIDSMDIFPVGWCEANSYPLTTP 475
Cdd:cd20121    6 EGMKVEVLNTDAvlPSRVyWIASVIQLAGYKALLRYEGFENdSSHDFWCNLGTVDVHPIGWCAINSKILVPP 77
MBT_SFMBT2_rpt4 cd20118
fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 ...
299-371 2.23e-03

fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439108  Cd Length: 91  Bit Score: 38.27  E-value: 2.23e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564392095 299 FTVGMRLETLHINDPFHIYPATVTKVFNSQFFqvaiddLRAEtnGLTM-----LCHADSLGILPVQWCLKNGVNLAPP 371
Cdd:cd20118    2 FTKNMKLEAVNPRNPAEICVASITSVKGRLLW------LHLE--GLQNpvpeyIVDVESMDIFPVGWCEANGYPLTPP 71
SAM_2 pfam07647
SAM domain (Sterile alpha motif);
817-881 2.80e-03

SAM domain (Sterile alpha motif);


Pssm-ID: 429573  Cd Length: 66  Bit Score: 36.86  E-value: 2.80e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564392095  817 PLEWSVTDVVRFIKLTDCAPLARIFQEQDIDG-QALLLLTLPTVQECMELKLGPAIKLCHQIERVK 881
Cdd:pfam07647   1 VESWSLESVADWLRSIGLEQYTDNFRDQGITGaELLLRLTLEDLKRLGITSVGHRRKILKKIQELK 66
MBT_SFMBT1_rpt4 cd20117
fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 ...
73-143 3.13e-03

fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439107  Cd Length: 90  Bit Score: 37.55  E-value: 3.13e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564392095  73 FQPGMKLEVANKNHPDTYWVATIITTCGQLLLLRYCGyGEDRRADFWCDVIIADLHPVGWCTQNNKVLRPP 143
Cdd:cd20117    3 FKENMKLEAVNPICPEEICVATVTKVKGSYLWLQLEG-SKKPIPECIVHVESMDIFPVGWCETNGYPLLHP 72
MBT_L3MBTL1_rpt3 cd20137
third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
187-255 3.22e-03

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.


Pssm-ID: 439127  Cd Length: 75  Bit Score: 37.11  E-value: 3.22e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564392095 187 VDSLIELQDSQNPFQYWIVSVIENVGGRLRLRYVGLEHTesYDRWLFYLDYRLRPIGWCQEKKYRMDPP 255
Cdd:cd20137    7 VNMKLEAVDRRNPALIRVASVEDVEDHRIKIHFDGWSHG--YDFWIDADHPDIHPAGWCSKTGHPLQPP 73
MBT_L3MBTL2_rpt4 cd20130
fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
296-371 4.33e-03

fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2); L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439120  Cd Length: 75  Bit Score: 36.89  E-value: 4.33e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564392095 296 SHFFTVGMRLETLHINDPFHIYPATVTKVFnSQFFQVAIDDLRAETNgltMLCHADSLGILPVQWCLKNGVNLAPP 371
Cdd:cd20130    3 NHGFKVGMKLEAVDLMEPRLICVATVKRVV-HRLLSIHFDGWDSEYD---QWVDCESPDIYPVGWCELTGYQLQPP 74
SAM_Ste50p pfam09235
Ste50p, sterile alpha motif; The fungal Ste50p SAM domain consists of five helices, which form ...
819-873 4.47e-03

Ste50p, sterile alpha motif; The fungal Ste50p SAM domain consists of five helices, which form a compact, globular fold. It is required for mediation of homodimerization and heterodimerization (and in some cases oligomerization) of the protein.


Pssm-ID: 401248  Cd Length: 75  Bit Score: 36.76  E-value: 4.47e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 564392095  819 EWSVTDVVRFIK----LTDCAPLARIFQEQDIDGQALLLLTLptvQECMEL---KLGPAIKL 873
Cdd:pfam09235   5 EWSTDEVCKWCKaelgLTEGDPLILRIRENKITGSTLSELTL---QDCKELcddDLSKAIKL 63
MBT_L3MBTL3_rpt3 cd20138
third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
296-371 9.23e-03

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.


Pssm-ID: 439128  Cd Length: 78  Bit Score: 36.06  E-value: 9.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564392095 296 SHFFTVGMRLETLHINDPFHIYPATVtkvfnsqffqVAIDDLRAE------TNGLTMLCHADSLGILPVQWCLKNGVNLA 369
Cdd:cd20138    6 PHGFQKNMKLEVVDKRNPMLIRVATV----------ADTDDHRVKvhfdgwNNCYDYWIDADSPDIHPAGWCAKTGHPLQ 75

                 ..
gi 564392095 370 PP 371
Cdd:cd20138   76 PP 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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