protein lyl-1 [Alligator mississippiensis]
Protein Classification
protein lyl-1( domain architecture ID 14444713)
protein lyl-1 is a proto-oncogenic bHLH transcription factor involved in T-cell acute lymphoblastic leukemia
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| bHLH_TS_LYL1 | cd19705 | basic helix-loop-helix (bHLH) domain found in protein lyl-1 and similar proteins; Lyl-1, also ... |
140-204 | 9.24e-39 | ||
basic helix-loop-helix (bHLH) domain found in protein lyl-1 and similar proteins; Lyl-1, also termed Class A basic helix-loop-helix protein 18 (bHLHa18), or lymphoblastic leukemia-derived sequence 1, is a proto-oncogenic bHLH transcription factor involved in T-cell acute lymphoblastic leukemia. It plays an important role in hematopoietic stem cell function and is required for the late stages of postnatal angiogenesis to limit the formation of new blood vessels, notably by regulating the activity of the small GTPase Rap1. LYL-1 deficiency induces a stress erythropoiesis. : Pssm-ID: 381548 [Multi-domain] Cd Length: 65 Bit Score: 129.37 E-value: 9.24e-39
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| Name | Accession | Description | Interval | E-value | ||
| bHLH_TS_LYL1 | cd19705 | basic helix-loop-helix (bHLH) domain found in protein lyl-1 and similar proteins; Lyl-1, also ... |
140-204 | 9.24e-39 | ||
basic helix-loop-helix (bHLH) domain found in protein lyl-1 and similar proteins; Lyl-1, also termed Class A basic helix-loop-helix protein 18 (bHLHa18), or lymphoblastic leukemia-derived sequence 1, is a proto-oncogenic bHLH transcription factor involved in T-cell acute lymphoblastic leukemia. It plays an important role in hematopoietic stem cell function and is required for the late stages of postnatal angiogenesis to limit the formation of new blood vessels, notably by regulating the activity of the small GTPase Rap1. LYL-1 deficiency induces a stress erythropoiesis. Pssm-ID: 381548 [Multi-domain] Cd Length: 65 Bit Score: 129.37 E-value: 9.24e-39
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| HLH | smart00353 | helix loop helix domain; |
150-202 | 2.66e-18 | ||
helix loop helix domain; Pssm-ID: 197674 [Multi-domain] Cd Length: 53 Bit Score: 75.72 E-value: 2.66e-18
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| HLH | pfam00010 | Helix-loop-helix DNA-binding domain; |
145-196 | 4.16e-17 | ||
Helix-loop-helix DNA-binding domain; Pssm-ID: 459628 [Multi-domain] Cd Length: 53 Bit Score: 72.88 E-value: 4.16e-17
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| Name | Accession | Description | Interval | E-value | ||
| bHLH_TS_LYL1 | cd19705 | basic helix-loop-helix (bHLH) domain found in protein lyl-1 and similar proteins; Lyl-1, also ... |
140-204 | 9.24e-39 | ||
basic helix-loop-helix (bHLH) domain found in protein lyl-1 and similar proteins; Lyl-1, also termed Class A basic helix-loop-helix protein 18 (bHLHa18), or lymphoblastic leukemia-derived sequence 1, is a proto-oncogenic bHLH transcription factor involved in T-cell acute lymphoblastic leukemia. It plays an important role in hematopoietic stem cell function and is required for the late stages of postnatal angiogenesis to limit the formation of new blood vessels, notably by regulating the activity of the small GTPase Rap1. LYL-1 deficiency induces a stress erythropoiesis. Pssm-ID: 381548 [Multi-domain] Cd Length: 65 Bit Score: 129.37 E-value: 9.24e-39
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| bHLH_TS_TAL_LYL | cd11413 | basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein/ ... |
145-204 | 6.03e-34 | ||
basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein/ lymphoblastic leukemia-derived sequence (TAL/LYL) family; The TAL/LYL family includes a group of bHLH transcription factors (TAL1, TAL2 and LYL1) implicated in T cell acute leukaemia. They act as mediators of T cell leukaemogenesis. TAL-1, also termed Class A basic helix-loop-helix protein 17 (bHLHa17), or stem cell protein (SCL), or T-cell leukemia/lymphoma protein 5, is a hematopoietic-specific bHLH transcription factor that functions in embryonic and adult hematopoiesis in vertebrates. It is also required for embryonic vascular remodeling. It acts as a regulator of erythroid differentiation and binds to regulatory regions of a large cohort of erythroid genes as part of a complex with GATA-1, LMO2 and Ldb1. TAL-2, also termed Class A basic helix-loop-helix protein 19 (bHLHa19), is a bHLH transcription factor essential for the normal brain development. Lyl-1, also termed Class A basic helix-loop-helix protein 18 (bHLHa18), or lymphoblastic leukemia-derived sequence 1, is a proto-oncogenic bHLH transcription factor that plays an important role in hematopoietic stem cell function and is required for the late stages of postnatal angiogenesis to limit the formation of new blood vessels, notably by regulating the activity of the small GTPase Rap1. LYL-1 deficiency induces a stress erythropoiesis. Pssm-ID: 381419 [Multi-domain] Cd Length: 60 Bit Score: 116.78 E-value: 6.03e-34
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| bHLH_TS_TAL1 | cd19706 | basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 1 ... |
142-204 | 1.02e-33 | ||
basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 1 (TAL-1) and similar proteins; TAL-1, also termed Class A basic helix-loop-helix protein 17 (bHLHa17), or stem cell protein (SCL), or T-cell leukemia/lymphoma protein 5, is a hematopoietic-specific bHLH transcription factor that functions in embryonic and adult hematopoiesis in vertebrates. It is also required for embryonic vascular remodeling. It acts as a regulator of erythroid differentiation and binds to regulatory regions of a large cohort of erythroid genes as part of a complex with GATA-1, LMO2 and Ldb1. TAL-1 has been implicated in T-cell acute lymphoblastic leukemia. In common with other tissue-specific bHLH proteins, Tal heterodimerizes with ubiquitously-expressed members of the E2A family and form a DNA-binding complex with an E-box (CANNTG) to regulate transcription at its recognition site. Pssm-ID: 381549 [Multi-domain] Cd Length: 65 Bit Score: 116.29 E-value: 1.02e-33
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| bHLH_TS_TAL2 | cd19707 | basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 2 ... |
145-203 | 2.99e-33 | ||
basic helix-loop-helix (bHLH) domain found in T-cell acute lymphocytic leukemia protein 2 (TAL-2) and similar proteins; TAL-2, also termed Class A basic helix-loop-helix protein 19 (bHLHa19), is a bHLH transcription factor essential for the normal brain development. It has been implicated in T-cell acute lymphoblastic leukemia. Pssm-ID: 381550 [Multi-domain] Cd Length: 61 Bit Score: 115.09 E-value: 2.99e-33
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| bHLH_TS_dHLH3B_like | cd19708 | basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster helix loop helix protein ... |
145-203 | 1.06e-30 | ||
basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster helix loop helix protein 3B (dHLH3B) and similar proteins; Drosophila HLH3B is an uncharacterized bHLH transcription factor that belongs to the T-cell acute lymphocytic leukemia protein/ lymphoblastic leukemia-derived sequence (TAL/LYL) family. Pssm-ID: 381551 [Multi-domain] Cd Length: 60 Bit Score: 108.44 E-value: 1.06e-30
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| bHLH_TS | cd11390 | tissue specific basic helix-loop-helix (bHLH-TS) domain family; Tissue specific bHLH domain ... |
146-200 | 2.24e-22 | ||
tissue specific basic helix-loop-helix (bHLH-TS) domain family; Tissue specific bHLH domain family includes transcription regulators whose expression are restricted to certain tissues. They are involved in cell-fate determination and process in neurogenesis, cardiogenesis, myogenesis, and hematopoiesis and include proteins from myogenic regulatory factor (MRF) family, twist-related protein (TWIST) family, scleraxis-like family, heart- and neural crest derivatives-expressed protein (HAND) family, helix-loop-helix protein (HEN) family, musculin-like family, germline alpha (FIGLA) family, T-cell acute lymphocytic leukemia protein/ lymphoblastic leukemia-derived sequence (TAL/LYL) family, ovary, uterus and testis protein (OUT) family, mesoderm posterior protein (Mesp) family, muscle, intestine and stomach expression 1 (MIST-1) family, protein atonal homologs (ATOH) family, neurogenin (NGN) family, neurogenic differentiation factor (NeuroD) family, achaete-scute complex-like (ASCL) family, Fer3-like protein (FERD3L)-like family, and Oligodendrocyte lineage genes (OLIG) family of transcription factors. Pssm-ID: 381396 [Multi-domain] Cd Length: 55 Bit Score: 86.47 E-value: 2.24e-22
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| HLH | smart00353 | helix loop helix domain; |
150-202 | 2.66e-18 | ||
helix loop helix domain; Pssm-ID: 197674 [Multi-domain] Cd Length: 53 Bit Score: 75.72 E-value: 2.66e-18
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| HLH | pfam00010 | Helix-loop-helix DNA-binding domain; |
145-196 | 4.16e-17 | ||
Helix-loop-helix DNA-binding domain; Pssm-ID: 459628 [Multi-domain] Cd Length: 53 Bit Score: 72.88 E-value: 4.16e-17
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| bHLH_TS_ASCL | cd11418 | basic helix-loop-helix (bHLH) domain found in achaete-scute complex-like (ASCL) family; The ... |
142-200 | 5.64e-16 | ||
basic helix-loop-helix (bHLH) domain found in achaete-scute complex-like (ASCL) family; The achaete-scute complex-like (ASCL, also known as achaete-scute complex homolog or ASH) family of bHLH transcription factors, ASCL1-5, have been implicated in cell fate specification and differentiation. They are critical for proper development of the nervous system. The deregulation of ASCL plays a key role in psychiatric and neurological disorders. ASCL-1, also termed Class A basic helix-loop-helix protein 46 (bHLHa46), or achaete-scute homolog 1 (ASH-1), or mammalian achaete-scute homolog 1 (Mash1), is a neural-specific bHLH transcription factor that is expressed in subsets of neural progenitors in both the central and peripheral nervous system. It plays a key role in neuronal differentiation and specification in the nervous system. ASCL-2, also termed achaete-scute homolog 2 (ASH-2), or Class A basic helix-loop-helix protein 45 (bHLHa45), or mammalian achaete-scute homolog 2 (Mash2), is a bHLH transcription factor that is involved in Schwann cell differentiation and control of proliferation in adult peripheral nerves. ASCL-3, also termed Class A basic helix-loop-helix protein 42 (bHLHa42), or bHLH transcriptional regulator Sgn-1, or achaete-scute homolog 3 (ASH-3), is a bHLH transcription factor specifically localized in the duct cells of the salivary glands. It may act as transcriptional repressor that inhibits myogenesis. The family also includes Drosophila melanogaster achaete-scute complex (AS-C) proteins, which consists of lethal of scute (also known as achaete-scute complex protein T3 or AST3), scute (also known as achaete-scute complex protein T4 or AST4), achaete (also known as achaete-scute complex protein T5 or AST5), and asense (also known as achaete-scute complex protein T8 or AST8). They are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system, as well as in sex determination and dosage compensation. Pssm-ID: 381424 [Multi-domain] Cd Length: 56 Bit Score: 69.94 E-value: 5.64e-16
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| bHLH_TS_scleraxis_like | cd11465 | basic helix-loop-helix (bHLH) domain found in scleraxis, transcription factor 15 (TCF-15) and ... |
150-200 | 6.53e-16 | ||
basic helix-loop-helix (bHLH) domain found in scleraxis, transcription factor 15 (TCF-15) and similar proteins; The family includes scleraxis and transcription factor 15 (TCF-15). Scleraxis, also termed SCX, or Class A basic helix-loop-helix protein 41 (bHLHa41), or Class A basic helix-loop-helix protein 48 (bHLHa48), is a bHLH transcription factor that is expressed in sclerotome limb bud cranial and body wall mesenchyme, pericardium and heart valves, ligaments and tendons. It is required for tendon formation ligaments, connective tissue, the diaphragm, and testis development. Scleraxis plays a central role in promoting fibroblast proliferation and matrix synthesis during the embryonic development of tendons. TCF-15, also termed Class A basic helix-loop-helix protein 40 (bHLHa40), or paraxis, or protein bHLH-EC2, is a bHLH transcription factor expressed in caudal lateral and paraxial mesoderm dermomyotome and sclerotome fore limb buds during embryo development. It may function as an early transcriptional regulator involved in the patterning of the mesoderm and in lineage determination of cell types derived from the mesoderm. Pssm-ID: 381471 [Multi-domain] Cd Length: 55 Bit Score: 69.75 E-value: 6.53e-16
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| bHLH_TS_HEN | cd11414 | basic helix-loop-helix (bHLH) domain found in helix-loop-helix protein (HEN) family; The HEN ... |
151-200 | 8.79e-15 | ||
basic helix-loop-helix (bHLH) domain found in helix-loop-helix protein (HEN) family; The HEN family includes two neuron-specific bHLH transcription factors, HEN-1 (also known as Nhlh1 or bHLHa35 or NSCL-1) and HEN-2 (also known as Nhlh2 or bHLHa34 or NSCL-2). They may serve as DNA-binding protein that is involved in the control of cell-type determination, possibly within the developing nervous system. Pssm-ID: 381420 Cd Length: 57 Bit Score: 66.78 E-value: 8.79e-15
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| bHLH_TS_FIGLA | cd11422 | basic helix-loop-helix (bHLH) domain found in factor in the germline alpha (FIGLA) and similar ... |
146-201 | 2.19e-14 | ||
basic helix-loop-helix (bHLH) domain found in factor in the germline alpha (FIGLA) and similar proteins; FIGLA, also termed FIGalpha, or Class C basic helix-loop-helix protein 8 (bHLHc8), or folliculogenesis-specific basic helix-loop-helix protein, or transcription factor FIGa, is a germ-cell-specific bHLH transcription factor expressed abundantly in female and less so in male germ cells. It is essential for primordial follicle formation and expression of many genes required for folliculogenesis, fertilization and early embryonic survival. FIGLA knockout mice cannot form primordial follicles and lose oocytes rapidly after birth, whereas male gonads are unaffected. Pssm-ID: 381428 Cd Length: 56 Bit Score: 65.45 E-value: 2.19e-14
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| bHLH_TS_TWIST1 | cd11412 | basic helix-loop-helix (bHLH) domain found in twist-related protein 1 (TWIST1) and similar ... |
145-201 | 2.58e-14 | ||
basic helix-loop-helix (bHLH) domain found in twist-related protein 1 (TWIST1) and similar proteins; TWIST1, also termed Class A basic helix-loop-helix protein 38 (bHLHa38), or H-twist, is a bHLH transcriptional regulator that inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. It also represses expression of proinflammatory cytokines such as TNFA and IL1B. In addition, TWIST1 is involved in cancer development and progression. Pssm-ID: 381418 [Multi-domain] Cd Length: 77 Bit Score: 65.96 E-value: 2.58e-14
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| bHLH_TS_TWIST | cd11464 | basic helix-loop-helix (bHLH) domain found in twist-related protein (TWIST) family; The TWIST ... |
145-201 | 3.03e-14 | ||
basic helix-loop-helix (bHLH) domain found in twist-related protein (TWIST) family; The TWIST family includes TWIST1 and TWIST2, which are highly homologous bHLH transcription factors that promote epithelial-mesenchymal transition (EMT) during development and tumor metastasis. They are involved in the negative regulation of cellular determination and in the differentiation of several lineages, including myogenesis, osteogenesis, and neurogenesis. TWIST factors express in broad partially-overlapping patterns during embryo development and dimerize with a broad sets of dimer partners that form numerous unique transcriptional complexes to regulate embryonic development. Pssm-ID: 381470 [Multi-domain] Cd Length: 59 Bit Score: 65.20 E-value: 3.03e-14
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| bHLH_TS_FERD3L_like | cd19686 | basic helix-loop-helix (bHLH) domain found in Fer3-like protein (FERD3L), pancreas ... |
150-200 | 3.44e-14 | ||
basic helix-loop-helix (bHLH) domain found in Fer3-like protein (FERD3L), pancreas transcription factor 1 subunit alpha (PTF1A) and similar proteins; The family corresponds to a group of bHLH transcription factors, including FERD3L and PTF1A. FERD3L, also termed basic helix-loop-helix protein N-twist, or Class A basic helix-loop-helix protein 31 (bHLHa31), or nephew of atonal 3 (NATO3), or Neuronal twist (NTWIST), is expressed in the developing central nervous system (CNS). It regulates floor plate (FP) cells development. FP is a critical organizing center located at the ventral-most midline of the neural tube. FERD3L binds to the E-box and functions as inhibitor of transcription. PTF1A, also termed Class A basic helix-loop-helix protein 29 (bHLHa29), or pancreas-specific transcription factor 1a, or bHLH transcription factor p48, or p48 DNA-binding subunit of transcription factor PTF1 (PTF1-p48), is implicated in the cell fate determination in various organs. It binds to the E-box consensus sequence 5'-CANNTG-3' and plays a role in early and late pancreas development and differentiation. Pssm-ID: 381529 [Multi-domain] Cd Length: 56 Bit Score: 65.14 E-value: 3.44e-14
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| bHLH_TS_HAND | cd11466 | basic helix-loop-helix (bHLH) domain found in heart- and neural crest derivatives-expressed ... |
145-200 | 5.75e-13 | ||
basic helix-loop-helix (bHLH) domain found in heart- and neural crest derivatives-expressed protein (HAND) family; The HAND family includes two bHLH transcription factors, HAND1 and HAND2. HAND1, also termed Class A basic helix-loop-helix protein 27 (bHLHa27), or extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1 (eHAND), plays an essential role in both trophoblast-giant cells differentiation and in cardiac morphogenesis. HAND2, also termed Class A basic helix-loop-helix protein 26 (bHLHa26), or deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2 (dHAND), is essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Pssm-ID: 381472 [Multi-domain] Cd Length: 56 Bit Score: 61.65 E-value: 5.75e-13
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| bHLH_TS_TCF15_paraxis | cd11470 | basic helix-loop-helix (bHLH) domain found in transcription factor 15 (TCF-15) and similar ... |
143-200 | 1.48e-12 | ||
basic helix-loop-helix (bHLH) domain found in transcription factor 15 (TCF-15) and similar proteins; TCF-15, also termed Class A basic helix-loop-helix protein 40 (bHLHa40), or paraxis, or protein bHLH-EC2, is a bHLH transcription factor expressed in caudal lateral and paraxial mesoderm dermomyotome and sclerotome fore limb buds during embryo development. It may function as an early transcriptional regulator involved in the patterning of the mesoderm and in lineage determination of cell types derived from the mesoderm. Pssm-ID: 381476 [Multi-domain] Cd Length: 66 Bit Score: 61.25 E-value: 1.48e-12
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| bHLH_TS_HAND2 | cd11471 | basic helix-loop-helix (bHLH) domain found in heart- and neural crest derivatives-expressed ... |
145-200 | 1.83e-12 | ||
basic helix-loop-helix (bHLH) domain found in heart- and neural crest derivatives-expressed protein 2 (HAND2) and similar proteins; HAND2, also termed Class A basic helix-loop-helix protein 26 (bHLHa26), or deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2 (dHAND), is a bHLH transcription factor that is essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Pssm-ID: 381477 [Multi-domain] Cd Length: 62 Bit Score: 60.84 E-value: 1.83e-12
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| bHLH_SF | cd00083 | basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators ... |
153-198 | 2.04e-12 | ||
basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators that are found in organisms from yeast to humans. Members of the bHLH superfamily have two highly conserved and functionally distinct regions. The basic part is at the amino end of the bHLH that may bind DNA to a consensus hexanucleotide sequence known as the E box (CANNTG). Different families of bHLH proteins recognize different E-box consensus sequences. At the carboxyl-terminal end of the region is the HLH region that interacts with other proteins to form homo- and heterodimers. bHLH proteins function as a diverse set of regulatory factors because they recognize different DNA sequences and dimerize with different proteins. The bHLH proteins can be divided to cell-type specific and widely expressed proteins. The cell-type specific members of bHLH superfamily are involved in cell-fate determination and act in neurogenesis, cardiogenesis, myogenesis, and hematopoiesis. Pssm-ID: 381392 [Multi-domain] Cd Length: 46 Bit Score: 59.84 E-value: 2.04e-12
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| bHLH_TS_ATOH1_like | cd11430 | basic helix-loop-helix (bHLH) domain found in protein atonal homologs ATOH1, ATOH7 and similar ... |
145-200 | 3.86e-12 | ||
basic helix-loop-helix (bHLH) domain found in protein atonal homologs ATOH1, ATOH7 and similar proteins; The family includes ATOH1 and ATOH7. ATOH1, also termed Class A basic helix-loop-helix protein 14 (bHLHa14), or helix-loop-helix protein hATH-1 (hATH1), or Math1, or Cath1, is a proneural bHLH transcription factor that is essential for inner ear hair cell differentiation. It dimerizes with E47 and activates E-box (CANNTG) dependent transcription. ATOH1 is a mammalian homolog of the Drosophila melanogaster gene atonal and mouse atonal homolog 1 (Math1). ATOH7, also termed Class A basic helix-loop-helix protein 13 (bHLHa13), or helix-loop-helix protein hATH-5 (hATH5), or Math5, is a bHLH transcription factor involved in the differentiation of retinal ganglion cells. The family also includes protein Amos (also termed absent MD neurons and olfactory sensilla protein, or reduced olfactory organs protein, or rough eye protein). It is a bHLH transcription factor that promotes multiple dendritic neuron formation in the Drosophila peripheral nervous system. Pssm-ID: 381436 [Multi-domain] Cd Length: 56 Bit Score: 59.76 E-value: 3.86e-12
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| bHLH_TS_NGN2_ATOH4 | cd19717 | basic helix-loop-helix (bHLH) domain found in neurogenin-2 (NGN-2) and similar proteins; NGN-2, ... |
142-201 | 6.46e-12 | ||
basic helix-loop-helix (bHLH) domain found in neurogenin-2 (NGN-2) and similar proteins; NGN-2, also termed Class A basic helix-loop-helix protein 8 (bHLHa8), or protein atonal homolog 4 (ATOH4), is a neural-specific bHLH transcription factor required for sensory neurogenesis. It activates transcription by binding to the E box (5'-CANNTG-3'). Pssm-ID: 381560 [Multi-domain] Cd Length: 69 Bit Score: 59.26 E-value: 6.46e-12
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| bHLH_TS_HEN1 | cd19701 | basic helix-loop-helix (bHLH) domain found in helix-loop-helix protein 1 (HEN-1) and similar ... |
151-200 | 7.44e-12 | ||
basic helix-loop-helix (bHLH) domain found in helix-loop-helix protein 1 (HEN-1) and similar proteins; HEN-1, also termed nescient helix-loop-helix 1 (Nhlh1), or Class A basic helix-loop-helix protein 35 (bHLHa35), or nescient helix loop helix 1 (NSCL-1), is a neuron-specific bHLH transcription factor that may serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system. Pssm-ID: 381544 [Multi-domain] Cd Length: 72 Bit Score: 59.29 E-value: 7.44e-12
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| bHLH_TS_NeuroD | cd11427 | basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor (NeuroD) ... |
146-200 | 8.01e-12 | ||
basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor (NeuroD) family; The NeuroD family includes NeuroD1, NeuroD2, NeuroD4 and NeuroD6. NeuroD1, also termed Class A basic helix-loop-helix protein 3 (bHLHa3), is a neuronal bHLH transcription factor involved in the development and maintenance of the endocrine pancreas and neuronal elements. It acts as an essential regulator of glutamatergic neuronal differentiation. Loss of NeuroD1 causes ataxia, cerebellar hypoplasia, sensorineural deafness, and severe retinal dystrophy in mice. NeuroD2, also termed Class A basic helix-loop-helix protein 1 (bHLHa1), or NeuroD-related factor (NDRF), is a neuronal calcium-dependent bHLH transcription factor that induces neuronal differentiation and promotes neuronal survival. It plays a central role in thalamocortical synaptic maturation. NeuroD2 mediates calcium-dependent transcription activation by binding to E box-containing promoter. NeuroD4, also termed Class A basic helix-loop-helix protein 4 (bHLHa4), or protein atonal homolog 3 (ATH-3), or Atoh3, or Math-3, is a bHLH transcriptional activator that mediates neuronal differentiation. NeuroD6, also termed Class A basic helix-loop-helix protein 2 (bHLHa2), or protein atonal homolog 2 (ATH-2), or Atoh2, or Math2, or Nex1, is a neurogenic bHLH transcription factor involved in neuronal development, differentiation, and survival in Alzheimer's disease (AD) brains of both cohorts. It plays an integrative role in coordinating increase in mitochondrial mass with cytoskeletal remodeling, suggesting that it may act as a co-regulator of neuronal differentiation and energy metabolism. Pssm-ID: 381433 [Multi-domain] Cd Length: 55 Bit Score: 58.57 E-value: 8.01e-12
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| bHLH_TS_ASCL3_like | cd19724 | basic helix-loop-helix (bHLH) domain found in achaete-scute-like proteins, ASCL3-5, and ... |
150-200 | 1.22e-11 | ||
basic helix-loop-helix (bHLH) domain found in achaete-scute-like proteins, ASCL3-5, and similar proteins; This subfamily includes three ASCL family of transcription factors, ASCL-3, ASCL-4 and ASCL-5. ASCL-3, also termed Class A basic helix-loop-helix protein 42 (bHLHa42), or bHLH transcriptional regulator Sgn-1, or achaete-scute homolog 3 (ASH-3), is specifically localized in the duct cells of the salivary glands. It may act as transcriptional repressor that inhibits myogenesis. ASCL-4, also termed Class A basic helix-loop-helix protein 44 (bHLHa44), or achaete-scute homolog 4 (ASH-4), or Hash4, may be involved in skin development. ASCL-5, also termed Class A basic helix-loop-helix protein 47 (bHLHa47), or achaete-scute homolog 5 (ASH-5), is an uncharacterized bHLH transcription factor that is close related to ASCL-3 and ASCL-4. Pssm-ID: 381567 Cd Length: 56 Bit Score: 58.08 E-value: 1.22e-11
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| bHLH_TS_taxi_Dei | cd11431 | basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster protein taxi and similar ... |
145-200 | 1.65e-11 | ||
basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster protein taxi and similar proteins; Protein taxi, also termed protein delilah (Dei), is a bHLH transcription factor that is involved in regulation of cell adhesion and attachment that is expressed in specialized cells that provide anchoring sites to either muscles (tendon cells), or proprioceptors (chordotonal attachment cells) during embryonic development. It probably plays an important role in the differentiation of epidermal cells into the tendon cells that form the attachment sites for all muscles. Pssm-ID: 381437 [Multi-domain] Cd Length: 59 Bit Score: 57.82 E-value: 1.65e-11
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| bHLH_TS_ATOH8 | cd11421 | basic helix-loop-helix (bHLH) domain found in protein atonal homolog 8 (ATOH8) and similar ... |
145-202 | 1.85e-11 | ||
basic helix-loop-helix (bHLH) domain found in protein atonal homolog 8 (ATOH8) and similar proteins; ATOH8, also termed Class A basic helix-loop-helix protein 21 (bHLHa21), or helix-loop-helix protein hATH-6 (hATH6), is a bHLH shear-stress-responsive transcription factor expressed in activated satellite cells and proliferating myoblasts of human skeletal muscle tissue. It regulates endothelial cell proliferation, migration and tube-like structures formation. ATOH8 binds a palindromic (canonical) core consensus DNA sequence 5'-CANNTG- 3' known as an E-box element, possibly as a heterodimer with other bHLH proteins. Pssm-ID: 381427 [Multi-domain] Cd Length: 68 Bit Score: 58.21 E-value: 1.85e-11
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| bHLH_TS_ATOH7 | cd19714 | basic helix-loop-helix (bHLH) domain found in protein atonal homolog 7 (ATOH7) and similar ... |
145-202 | 2.68e-11 | ||
basic helix-loop-helix (bHLH) domain found in protein atonal homolog 7 (ATOH7) and similar proteins; ATOH7, also termed Class A basic helix-loop-helix protein 13 (bHLHa13), or helix-loop-helix protein hATH-5 (hATH5), or Math5, is a bHLH transcription factor involved in the differentiation of retinal ganglion cells. Pssm-ID: 381557 [Multi-domain] Cd Length: 69 Bit Score: 57.65 E-value: 2.68e-11
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| bHLH_TS_TWIST2 | cd19700 | basic helix-loop-helix (bHLH) domain found in twist-related protein 2 (TWIST2) and similar ... |
144-201 | 2.71e-11 | ||
basic helix-loop-helix (bHLH) domain found in twist-related protein 2 (TWIST2) and similar proteins; TWIST2, also termed Class A basic helix-loop-helix protein 39 (bHLHa39), or Dermis-expressed protein 1, or Dermo-1, is a bHLH transcription factor that regulates the development of mesenchymal tissues and plays a critical role in embryogenesis. It binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Pssm-ID: 381543 [Multi-domain] Cd Length: 82 Bit Score: 58.26 E-value: 2.71e-11
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| bHLH_TS_NGN1_NeuroD3 | cd19716 | basic helix-loop-helix (bHLH) domain found in neurogenin-1 (NGN-1) and similar proteins; NGN-1, ... |
142-201 | 3.28e-11 | ||
basic helix-loop-helix (bHLH) domain found in neurogenin-1 (NGN-1) and similar proteins; NGN-1, also termed Class A basic helix-loop-helix protein 6 (bHLHa6), or neurogenic basic-helix-loop-helix protein, or neurogenic differentiation factor 3 (NeuroD3), is a neural-specific bHLH transcription factor involved in the initiation of neuronal differentiation. It activates transcription by binding to the E box (5'-CANNTG-3'). Pssm-ID: 381559 [Multi-domain] Cd Length: 77 Bit Score: 57.73 E-value: 3.28e-11
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| bHLH_TS_HEN2 | cd19702 | basic helix-loop-helix (bHLH) domain found in helix-loop-helix protein 2 (HEN-2) and similar ... |
151-200 | 5.60e-11 | ||
basic helix-loop-helix (bHLH) domain found in helix-loop-helix protein 2 (HEN-2) and similar proteins; HEN-2, also termed nescient helix-loop-helix 2 (Nhlh2), or Class A basic helix-loop-helix protein 34 (bHLHa34), or nescient helix loop helix 2 (NSCL-2), is a neuron-specific bHLH transcription factor that may serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system. Pssm-ID: 381545 [Multi-domain] Cd Length: 73 Bit Score: 57.02 E-value: 5.60e-11
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| bHLH_TS_PTF1A | cd11417 | basic helix-loop-helix (bHLH) domain found in pancreas transcription factor 1 subunit alpha ... |
145-200 | 7.04e-11 | ||
basic helix-loop-helix (bHLH) domain found in pancreas transcription factor 1 subunit alpha (PTF1A) and similar proteins; PTF1A, also termed Class A basic helix-loop-helix protein 29 (bHLHa29), or pancreas-specific transcription factor 1a, or bHLH transcription factor p48, or p48 DNA-binding subunit of transcription factor PTF1 (PTF1-p48), is a bHLH transcription factor implicated in the cell fate determination in various organs. It binds to the E-box consensus sequence 5'-CANNTG-3' and plays a role in early and late pancreas development and differentiation. Pssm-ID: 381423 [Multi-domain] Cd Length: 56 Bit Score: 56.39 E-value: 7.04e-11
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| bHLH_TS_NGN3_ATOH5 | cd19718 | basic helix-loop-helix (bHLH) domain found in neurogenin-3 (NGN-3) and similar proteins; NGN-3, ... |
142-201 | 7.89e-11 | ||
basic helix-loop-helix (bHLH) domain found in neurogenin-3 (NGN-3) and similar proteins; NGN-3, also termed Class A basic helix-loop-helix protein 7 (bHLHa7), or protein atonal homolog 5 (ATOH5), is a neural-specific bHLH transcription factor expressed in the developing central nervous system and the embryonic pancreas. It is involved in neurogenesis and plays an important role in spermatogenesis. Pssm-ID: 381561 [Multi-domain] Cd Length: 68 Bit Score: 56.58 E-value: 7.89e-11
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| bHLH_TS_NGN | cd11428 | basic helix-loop-helix (bHLH) domain found in neurogenin (NGN) family; The NGN family includes ... |
145-201 | 1.19e-10 | ||
basic helix-loop-helix (bHLH) domain found in neurogenin (NGN) family; The NGN family includes three neural-specific bHLH transcription factors, NGN1-3, which may function at neuroblast selection genes during the development of several neuronal lineages. NGN-1, also termed Class A basic helix-loop-helix protein 6 (bHLHa6), or neurogenic basic-helix-loop-helix protein, or neurogenic differentiation factor 3 (NeuroD3), is a neural-specific bHLH transcription factor involved in the initiation of neuronal differentiation. NGN-2, also termed Class A basic helix-loop-helix protein 8 (bHLHa8), or protein atonal homolog 4 (ATOH4), is a neural-specific bHLH transcription factor required for sensory neurogenesis. NGN-3, also termed Class A basic helix-loop-helix protein 7 (bHLHa7), or protein atonal homolog 5 (ATOH5), is a neural-specific bHLH transcription factor expressed in the developing central nervous system and the embryonic pancreas. It is involved in neurogenesis and plays an important role in spermatogenesis. Pssm-ID: 381434 [Multi-domain] Cd Length: 57 Bit Score: 55.52 E-value: 1.19e-10
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| bHLH_TS_HAND1 | cd18952 | basic helix-loop-helix (bHLH) domain found in heart- and neural crest derivatives-expressed ... |
145-200 | 1.22e-10 | ||
basic helix-loop-helix (bHLH) domain found in heart- and neural crest derivatives-expressed protein 1 (HAND1) and similar proteins; HAND1, also termed Class A basic helix-loop-helix protein 27 (bHLHa27), or extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1 (eHAND), is a bHLH transcription factor that plays an essential role in both trophoblast-giant cells differentiation and in cardiac morphogenesis. Pssm-ID: 381522 [Multi-domain] Cd Length: 60 Bit Score: 55.80 E-value: 1.22e-10
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| bHLH_TS_ATOH1 | cd19713 | basic helix-loop-helix (bHLH) domain found in protein atonal homolog 1 (ATOH1) and similar ... |
145-200 | 4.07e-10 | ||
basic helix-loop-helix (bHLH) domain found in protein atonal homolog 1 (ATOH1) and similar proteins; ATOH1, also termed Class A basic helix-loop-helix protein 14 (bHLHa14), or helix-loop-helix protein hATH-1 (hATH1), or Math1, or Cath1, is a proneural bHLH transcription factor that is essential for inner ear hair cell differentiation. It dimerizes with E47 and activates E-box (CANNTG) dependent transcription. ATOH1 is a mammalian homolog of the Drosophila melanogaster gene atonal and mouse atonal homolog 1 (Math1). Pssm-ID: 381556 Cd Length: 64 Bit Score: 54.19 E-value: 4.07e-10
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| bHLH_TS_FERD3L_NATO3 | cd11415 | basic helix-loop-helix (bHLH) domain found in Fer3-like protein (FERD3L) and similar proteins; ... |
143-200 | 4.54e-10 | ||
basic helix-loop-helix (bHLH) domain found in Fer3-like protein (FERD3L) and similar proteins; FERD3L, also termed basic helix-loop-helix protein N-twist, or Class A basic helix-loop-helix protein 31 (bHLHa31), or nephew of atonal 3 (NATO3), or Neuronal twist (NTWIST), is a bHLH transcription factor expressed in the developing central nervous system (CNS). It regulates floor plate (FP) cells development. FP is a critical organizing center located at the ventral-most midline of the neural tube. FERD3L binds to the E-box and functions as inhibitor of transcription. Pssm-ID: 381421 [Multi-domain] Cd Length: 64 Bit Score: 54.36 E-value: 4.54e-10
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| bHLH_TS_ceHLH13_like | cd11416 | basic helix-loop-helix (bHLH) domain found in Caenorhabditis elegans Helix-loop-helix protein ... |
140-201 | 5.80e-10 | ||
basic helix-loop-helix (bHLH) domain found in Caenorhabditis elegans Helix-loop-helix protein 13 (HLH13) and similar proteins; Caenorhabditis elegans HLH13, also termed Fer3-like protein, or nephew of atonal 3, is a bHLH transcription factor that plays a role in the negative regulation of exit from L1 arrest and dauer diapause dependent on IIS signaling (insulin and insulin-like growth factor (IGF) signaling). Pssm-ID: 381422 [Multi-domain] Cd Length: 63 Bit Score: 54.05 E-value: 5.80e-10
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| bHLH_TS_scleraxis | cd18951 | basic helix-loop-helix (bHLH) domain found in scleraxis and similar proteins; Scleraxis, also ... |
145-200 | 6.45e-10 | ||
basic helix-loop-helix (bHLH) domain found in scleraxis and similar proteins; Scleraxis, also termed SCX, or Class A basic helix-loop-helix protein 41 (bHLHa41), or Class A basic helix-loop-helix protein 48 (bHLHa48), is a bHLH transcription factor that is expressed in sclerotome limb bud cranial and body wall mesenchyme, pericardium and heart valves, ligaments and tendons. It is required for tendon formation ligaments, connective tissue, the diaphragm, and testis development. Scleraxis plays a central role in promoting fibroblast proliferation and matrix synthesis during the embryonic development of tendons. Pssm-ID: 381521 [Multi-domain] Cd Length: 68 Bit Score: 54.01 E-value: 6.45e-10
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| bHLH_TS_amos_like | cd19715 | basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster protein Amos and similar ... |
145-200 | 8.72e-10 | ||
basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster protein Amos and similar proteins; Amos, also termed absent MD neurons and olfactory sensilla protein, or reduced olfactory organs protein, or rough eye protein, is a bHLH transcription factor that promotes multiple dendritic neuron formation in the Drosophila peripheral nervous system. Pssm-ID: 381558 [Multi-domain] Cd Length: 64 Bit Score: 53.30 E-value: 8.72e-10
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| bHLH_TS_TCF24 | cd19710 | basic helix-loop-helix (bHLH) domain found in transcription factor 24 (TCF-24) and similar ... |
151-200 | 1.26e-09 | ||
basic helix-loop-helix (bHLH) domain found in transcription factor 24 (TCF-24) and similar proteins; TCF-24 is an uncharacterized bHLH transcription factor that shows high sequence similarity with TCF-23. Pssm-ID: 381553 Cd Length: 56 Bit Score: 52.63 E-value: 1.26e-09
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| bHLH_TS_ASCL1_like | cd19723 | basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster achaete-scute complex ... |
143-200 | 2.32e-09 | ||
basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster achaete-scute complex (AS-C) proteins, achaete-scute-like proteins, ASCL1-2, and similar proteins; This subfamily includes Drosophila melanogaster AS-C proteins and two ASCL family of transcription factors, ASCL-1 and ASCL-2. Drosophila melanogaster AS-C proteins includes lethal of scute (also known as achaete-scute complex protein T3 or AST3), scute (also known as achaete-scute complex protein T4 or AST4), achaete (also known as achaete-scute complex protein T5 or AST5), and asense (also known as achaete-scute complex protein T8 or AST8). They are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system, as well as in sex determination and dosage compensation. ASCL-1, also termed Class A basic helix-loop-helix protein 46 (bHLHa46), or achaete-scute homolog 1 (ASH-1), or mammalian achaete scute homolog 1 (Mash1), is expressed in subsets of neural progenitors in both the central and peripheral nervous system. It plays a key role in neuronal differentiation and specification in the nervous system. ASCL-2, also termed achaete-scute homolog 2 (ASH-2), or Class A basic helix-loop-helix protein 45 (bHLHa45), or mammalian achaete scute homolog 2 (Mash2), is involved in Schwann cell differentiation and control of proliferation in adult peripheral nerves. Pssm-ID: 381566 Cd Length: 56 Bit Score: 52.06 E-value: 2.32e-09
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| bHLH_TS_MIST1 | cd19711 | basic helix-loop-helix (bHLH) domain found in muscle, intestine and stomach expression 1 ... |
145-196 | 3.86e-09 | ||
basic helix-loop-helix (bHLH) domain found in muscle, intestine and stomach expression 1 (MIST-1) and similar proteins; MIST-1, also termed Class A basic helix-loop-helix protein 15 (bHLHa15), or Class B basic helix-loop-helix protein 8 (bHLHb8), is a bHLH transcription factor expressed in pancreatic acinar cells and other serous exocrine cells. It is essential for cytoskeletal organization and secretory activity. It also functions as a potent endoplasmic reticulum (ER) stress-inducible transcriptional regulator. MIST-1 is capable of binding to E-box (CANNTG) motifs as a homodimer or a heterodimer with E-proteins (E12 and E47) to regulate transcription. Pssm-ID: 381554 Cd Length: 62 Bit Score: 51.64 E-value: 3.86e-09
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| bHLH_TS_NeuroD6_ATOH2 | cd19722 | basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 6 (NeuroD6) ... |
145-201 | 5.37e-09 | ||
basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 6 (NeuroD6) and similar proteins; NeuroD6, also termed Class A basic helix-loop-helix protein 2 (bHLHa2), or protein atonal homolog 2 (ATH-2), or Atoh2, or Math2, or Nex1, is a neurogenic bHLH transcription factor involved in neuronal development, differentiation, and survival in Alzheimer's disease (AD) brains of both cohorts. It plays an integrative role in coordinating increase in mitochondrial mass with cytoskeletal remodeling, suggesting that it may act as a co-regulator of neuronal differentiation and energy metabolism. Pssm-ID: 381565 [Multi-domain] Cd Length: 70 Bit Score: 51.57 E-value: 5.37e-09
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| bHLH_TS_OUT | cd11424 | basic helix-loop-helix (bHLH) domain found in ovary, uterus and testis protein (OUT) family; ... |
151-200 | 7.03e-09 | ||
basic helix-loop-helix (bHLH) domain found in ovary, uterus and testis protein (OUT) family; The OUT family includes transcription factor 23 (TCF-23), transcription factor 24 (TCF-24) and similar proteins. TCF-23, also termed Class A basic helix-loop-helix protein 24 (bHLHa24), is a bHLH transcription factor that is essential for progesterone-dependent decidualization. The mouse homolog is also called ovary, uterus and testis protein (OUT), which is expressed predominantly in the reproductive organs such as the uterus, ovary and testis. It shows an Id-like inhibitory activity and functions as a negative regulator of bHLH factors through the formation of a functionally inactive heterodimeric complex. OUT inhibits the formation of TCF3 and MYOD1 homodimers and heterodimers, but lacks DNA binding activity. OUT is involved in the regulation or modulation of smooth muscle contraction of the uterus during pregnancy and particularly around the time of delivery. It also plays a role in the inhibition of myogenesis. Unlike typical bHLH factors, OUT proteins do not bind E-box (CANNTG) or N-box DNA sequences and inhibit DNA binding of homo- and heterodimers consisting of E12 and MyoD in gel mobility shift assays. TCF-24 is an uncharacterized bHLH transcription factor that shows high sequence similarity with TCF-23. Pssm-ID: 381430 Cd Length: 55 Bit Score: 50.60 E-value: 7.03e-09
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| bHLH_TS_musculin_like | cd11423 | basic helix-loop-helix (bHLH) domain found in musculin, transcription factor 21 (TCF-21) and ... |
150-200 | 8.40e-09 | ||
basic helix-loop-helix (bHLH) domain found in musculin, transcription factor 21 (TCF-21) and similar proteins; The family includes two bHLH transcription factors, musculin and transcription factor 21 (TCF-21). Musculin, also termed activated B-cell factor 1 (ABF-1), or Class A basic helix-loop-helix protein 22 (bHLHa22), is a bHLH transcription factor expressed in activated B lymphocytes. It acts as a transcription repressor capable of inhibiting the transactivation capability of TCF3/E47. Musculin may play a role in regulating antigen-dependent B-cell differentiation. The mouse homolog, musculin, is suggested to be a repressor of myogenesis that is expressed in developing muscle and in the spleen. TCF-21, also termed capsulin, or Class A basic helix-loop-helix protein 23 (bHLHa23), or epicardin, or podocyte-expressed 1 (Pod-1), is a bHLH transcription factor expressed specifically in mesodermally-derived cells that surround the epithelium of the developing gastrointestinal, genitourinary and respiratory systems during mouse embryogenesis. It may play a role in the specification or differentiation of one or more subsets of epicardial cell types. Pssm-ID: 381429 [Multi-domain] Cd Length: 56 Bit Score: 50.58 E-value: 8.40e-09
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| bHLH_TS_ASCL2_Mash2 | cd19743 | basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 2 (ASCL-2) and ... |
143-206 | 1.33e-08 | ||
basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 2 (ASCL-2) and similar proteins; ASCL-2, also termed achaete-scute homolog 2 (ASH-2), or Class A basic helix-loop-helix protein 45 (bHLHa45), or mammalian achaete scute homolog 2 (Mash2), is a bHLH transcription factor that is involved in Schwann cell differentiation and control of proliferation in adult peripheral nerves. Pssm-ID: 381586 Cd Length: 64 Bit Score: 50.35 E-value: 1.33e-08
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| bHLH_TS_NeuroD4_ATOH3 | cd19721 | basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 4 (NeuroD4) ... |
144-201 | 1.47e-08 | ||
basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 4 (NeuroD4) and similar proteins; NeuroD4, also termed Class A basic helix-loop-helix protein 4 (bHLHa4), or protein atonal homolog 3 (ATH-3), or Atoh3, or Math-3, is a bHLH transcriptional activator that mediates neuronal differentiation. Pssm-ID: 381564 [Multi-domain] Cd Length: 87 Bit Score: 50.85 E-value: 1.47e-08
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| bHLH_TS_ASCL1_Mash1 | cd19742 | basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 1 (ASCL-1) and ... |
139-203 | 2.61e-08 | ||
basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 1 (ASCL-1) and similar proteins; ASCL-1, also termed Class A basic helix-loop-helix protein 46 (bHLHa46), or achaete-scute homolog 1 (ASH-1), or mammalian achaete scute homolog 1 (Mash1), is a neural-specific bHLH transcription factor that is expressed in subsets of neural progenitors in both the central and peripheral nervous system. It plays a key role in neuronal differentiation and specification in the nervous system. Pssm-ID: 381585 Cd Length: 71 Bit Score: 49.75 E-value: 2.61e-08
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| bHLH_TS_ASCL3 | cd19745 | basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 3 (ASCL-3) and ... |
150-200 | 4.10e-08 | ||
basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 3 (ASCL-3) and similar proteins; ASCL-3, also termed Class A basic helix-loop-helix protein 42 (bHLHa42), or bHLH transcriptional regulator Sgn-1, or achaete-scute homolog 3 (ASH-3), is a bHLH transcription factor specifically localized in the duct cells of the salivary glands. It may act as transcriptional repressor that inhibits myogenesis. Pssm-ID: 381588 Cd Length: 59 Bit Score: 48.70 E-value: 4.10e-08
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| bHLH_TS_Mesp_like | cd11425 | basic helix-loop-helix (bHLH) domain found in mesoderm posterior protein (Mesp) family; Mesp, ... |
145-200 | 4.37e-08 | ||
basic helix-loop-helix (bHLH) domain found in mesoderm posterior protein (Mesp) family; Mesp, a bHLH tissue specific transcription factor, acts as a key regulator of the cardiovascular transcriptional network by inducing directly and/or indirectly the expression of the majority of key cardiovascular transcription factors. The Mesp family includes two bHLH transcription factors, Mesp1 and Mesp2. Mesp1, also termed Class C basic helix-loop-helix protein 5 (bHLHc5), promotes cardiovascular differentiation during embryonic development and embryonic stem cell differentiation. Mesp2, also termed Class C basic helix-loop-helix protein 6 (bHLHc6), plays an important role in somitogenesis. The family also includes mesogenin-1 (Msgn1) and similar proteins. Msgn1, also termed paraxial mesoderm-specific mesogenin1, or pMesogenin1 (pMsgn1), is a bHLH transcription factor required for maturation and segmentation of paraxial mesoderm. It may regulate the expression of T-box transcription factors essential for mesoderm formation and differentiation. Pssm-ID: 381431 [Multi-domain] Cd Length: 59 Bit Score: 48.64 E-value: 4.37e-08
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| bHLHzip_TFAP4 | cd11419 | basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor AP-4 (TFAP4) and ... |
145-193 | 6.73e-08 | ||
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor AP-4 (TFAP4) and similar proteins; TFAP4, also termed activating enhancer-binding protein 4, or Class C basic helix-loop-helix protein 41 (bHLHc41), is a bHLHzip transcription factor that activates both viral and cellular genes involved in the regulation of cellular proliferation, stemness, and epithelial-mesenchymal transition by binding to the symmetrical DNA sequence 5'-CAGCTG-3'. Pssm-ID: 381425 Cd Length: 61 Bit Score: 48.08 E-value: 6.73e-08
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| bHLH_TS_TCF23_OUT | cd19709 | basic helix-loop-helix (bHLH) domain found in transcription factor 23 (TCF-23) and similar ... |
151-200 | 6.75e-08 | ||
basic helix-loop-helix (bHLH) domain found in transcription factor 23 (TCF-23) and similar proteins; TCF-23, also termed Class A basic helix-loop-helix protein 24 (bHLHa24), is a bHLH transcription factor that is essential for progesterone-dependent decidualization. The mouse homolog is also called ovary, uterus and testis protein (OUT), which is expressed predominantly in the reproductive organs such as the uterus, ovary and testis. It shows an Id-like inhibitory activity and functions as a negative regulator of bHLH factors through the formation of a functionally inactive heterodimeric complex. OUT inhibits the formation of TCF3 and MYOD1 homodimers and heterodimers, but lacks DNA binding activity. OUT is involved in the regulation or modulation of smooth muscle contraction of the uterus during pregnancy and particularly around the time of delivery. It also plays a role in the inhibition of myogenesis. Unlike typical bHLH factors, OUT proteins do not bind E-box (CANNTG) or N-box DNA sequences and inhibit DNA binding of homo- and heterodimers consisting of E12 and MyoD in gel mobility shift assays. Pssm-ID: 381552 Cd Length: 56 Bit Score: 48.17 E-value: 6.75e-08
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| bHLH_TS_MIST1_like | cd11426 | basic helix-loop-helix (bHLH) domain found in muscle, intestine and stomach expression 1 ... |
145-193 | 1.58e-07 | ||
basic helix-loop-helix (bHLH) domain found in muscle, intestine and stomach expression 1 (MIST-1) family; MIST-1, also termed Class A basic helix-loop-helix protein 15 (bHLHa15), or Class B basic helix-loop-helix protein 8 (bHLHb8), is a bHLH transcription factor expressed in pancreatic acinar cells and other serous exocrine cells. It is essential for cytoskeletal organization and secretory activity. It also functions as a potent endoplasmic reticulum (ER) stress-inducible transcriptional regulator. MIST-1 is capable of binding to E-box (CANNTG) motifs as a homodimer or a heterodimer with E-proteins (E12 and E47) to regulate transcription. The family also includes Drosophila melanogaster protein dimmed and similar proteins. Dimmed, also termed DIMM, is a bHLH transcription factor that regulates neurosecretory (NS) cell function and neuroendocrine cell fate in Drosophila. Pssm-ID: 381432 Cd Length: 56 Bit Score: 47.20 E-value: 1.58e-07
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| bHLH_TS_ASCL5 | cd19747 | basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 5 (ASCL-5) and ... |
150-200 | 1.75e-07 | ||
basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 5 (ASCL-5) and similar proteins; ASCL-5, also termed Class A basic helix-loop-helix protein 47 (bHLHa47), or achaete-scute homolog 5 (ASH-5), is an uncharacterized bHLH transcription factor that belongs to AS-C (achaete, scute, lethal of scute, and asense) family. Pssm-ID: 381590 Cd Length: 61 Bit Score: 46.92 E-value: 1.75e-07
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| bHLH_TS_dimmed_like | cd19712 | basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster protein dimmed and ... |
145-193 | 1.86e-07 | ||
basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster protein dimmed and similar proteins; Dimmed, also termed DIMM, is a bHLH transcription factor that regulates neurosecretory (NS) cell function and neuroendocrine cell fate in Drosophila. Pssm-ID: 381555 [Multi-domain] Cd Length: 60 Bit Score: 47.10 E-value: 1.86e-07
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| bHLH_TS_musculin | cd19703 | basic helix-loop-helix (bHLH) domain found in musculin and similar proteins; Musculin, also ... |
142-202 | 1.89e-07 | ||
basic helix-loop-helix (bHLH) domain found in musculin and similar proteins; Musculin, also termed activated B-cell factor 1 (ABF-1), or Class A basic helix-loop-helix protein 22 (bHLHa22), is a bHLH transcription factor expressed in activated B lymphocytes. It acts as a transcription repressor capable of inhibiting the transactivation capability of TCF3/E47. Musculin may play a role in regulating antigen-dependent B-cell differentiation. The mouse homolog, musculin, is suggested to be a repressor of myogenesis that is expressed in developing muscle and in the spleen. Musculin heterodimerizes with products of the E2A gene. Pssm-ID: 381546 [Multi-domain] Cd Length: 66 Bit Score: 47.06 E-value: 1.89e-07
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| bHLH_TS_TCF21_capsulin | cd19704 | basic helix-loop-helix (bHLH) domain found in transcription factor 21 (TCF-21) and similar ... |
142-200 | 2.01e-07 | ||
basic helix-loop-helix (bHLH) domain found in transcription factor 21 (TCF-21) and similar proteins; TCF-21, also termed capsulin, or Class A basic helix-loop-helix protein 23 (bHLHa23), or epicardin, or podocyte-expressed 1 (Pod-1), is a bHLH transcription factor expressed specifically in mesodermally-derived cells that surround the epithelium of the developing gastrointestinal, genitourinary and respiratory systems during mouse embryogenesis. It may play a role in the specification or differentiation of one or more subsets of epicardial cell types. Pssm-ID: 381547 [Multi-domain] Cd Length: 64 Bit Score: 47.12 E-value: 2.01e-07
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| bHLH_TS_NeuroD2 | cd19720 | basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 2 (NeuroD2) ... |
145-201 | 2.02e-07 | ||
basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 2 (NeuroD2) and similar proteins; NeuroD2, also termed Class A basic helix-loop-helix protein 1 (bHLHa1), or NeuroD-related factor (NDRF), is a neuronal calcium-dependent bHLH transcription factor that induces neuronal differentiation and promotes neuronal survival. It plays a central role in thalamocortical synaptic maturation. NeuroD2 mediates calcium-dependent transcription activation by binding to E box-containing promoter. Pssm-ID: 381563 [Multi-domain] Cd Length: 93 Bit Score: 47.76 E-value: 2.02e-07
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| bHLH_TS_dAS-C_like | cd19744 | basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster achaete-scute complex ... |
143-200 | 3.54e-07 | ||
basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster achaete-scute complex (AS-C) proteins and similar proteins; Drosophila melanogaster AS-C proteins includes lethal of scute (also known as achaete-scute complex protein T3 or AST3), scute (also known as achaete-scute complex protein T4 or AST4), achaete (also known as achaete-scute complex protein T5 or AST5), and asense (also known as achaete-scute complex protein T8 or AST8). They are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system, as well as in sex determination and dosage compensation. Pssm-ID: 381587 [Multi-domain] Cd Length: 67 Bit Score: 46.43 E-value: 3.54e-07
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| bHLH_TS_ASCL4 | cd19746 | basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 4 (ASCL-4) and ... |
150-200 | 4.10e-07 | ||
basic helix-loop-helix (bHLH) domain found in achaete-scute-like protein 4 (ASCL-4) and similar proteins; ASCL-4, also termed Class A basic helix-loop-helix protein 44 (bHLHa44), or achaete-scute homolog 4 (ASH-4), or Hash4, is a bHLH transcriptional regulator that may be involved in skin development. Pssm-ID: 381589 Cd Length: 64 Bit Score: 46.18 E-value: 4.10e-07
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| bHLH_dnHLH_ID4 | cd19694 | basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID4 and similar ... |
157-193 | 5.21e-07 | ||
basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID4 and similar proteins; ID4, also termed Class B basic helix-loop-helix protein 27 (bHLHb27), or inhibitor of DNA binding 4, or inhibitor of differentiation 4, is a dominant negative helix-loop-helix (dnHLH) transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the bHLH transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. It plays a role in adipose cell differentiation. Pssm-ID: 381537 Cd Length: 60 Bit Score: 45.77 E-value: 5.21e-07
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| bHLH_TS_Myf5 | cd18937 | basic helix-loop-helix (bHLH) domain found in myogenic factor 5 (Myf-5) and similar proteins; ... |
145-203 | 1.92e-06 | ||
basic helix-loop-helix (bHLH) domain found in myogenic factor 5 (Myf-5) and similar proteins; Myf-5, also termed Class C basic helix-loop-helix protein 2 (bHLHc2), is a nuclear bHLH transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle specification and differentiation. It also acts as an RNA-binding protein which enhances Ccnd1/Cyclin D1 mRNA translation during myogenesis. Pssm-ID: 381507 Cd Length: 64 Bit Score: 44.35 E-value: 1.92e-06
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| bHLH_TS_NeuroD1 | cd19719 | basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 1 (NeuroD1) ... |
145-201 | 2.26e-06 | ||
basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 1 (NeuroD1) and similar proteins; NeuroD1, also termed Class A basic helix-loop-helix protein 3 (bHLHa3), is a neuronal bHLH transcription factor involved in the development and maintenance of the endocrine pancreas and neuronal elements. It acts as an essential regulator of glutamatergic neuronal differentiation. Loss of NeuroD1 causes ataxia, cerebellar hypoplasia, sensorineural deafness, and severe retinal dystrophy in mice. Pssm-ID: 381562 Cd Length: 86 Bit Score: 44.78 E-value: 2.26e-06
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| bHLH_TS_MYOD1_Myf3 | cd18936 | basic helix-loop-helix (bHLH) domain found in myoblast determination protein 1 (MYOD1) and ... |
145-201 | 2.92e-06 | ||
basic helix-loop-helix (bHLH) domain found in myoblast determination protein 1 (MYOD1) and similar proteins; MYOD1, also termed Class C basic helix-loop-helix protein 1 (bHLHc1), or myogenic factor 3 (Myf-3), is a bHLH transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with Myf-5 and MYOG, MYOD1 co-occupies muscle-specific gene promoter core region during myogenesis. Pssm-ID: 381506 Cd Length: 61 Bit Score: 43.51 E-value: 2.92e-06
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| bHLHzip_USF_MITF | cd11387 | basic Helix-Loop-Helix-zipper (bHLHzip) domain found in USF/MITF family; The USF (upstream ... |
150-193 | 5.56e-06 | ||
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in USF/MITF family; The USF (upstream stimulatory factor)/MITF (microphthalmia-associated transcription factor) family includes two bHLHzip transcription factor subfamilies. USFs are ubiquitously expressed and key regulators of a wide number of gene regulation networks, including the stress and immune responses, cell cycle and proliferation, lipid and glucid metabolism. USFs recruit chromatin remodeling enzymes and interact with co-activators and the members of the transcription pre-initiation complex. USFs interact with high affinity to E-box regulatory elements. The MITF (also known as microphthalmia-TFE, or MiT) subfamily comprises four genes in mammals (MITF, TFE3, TFEB, and TFEC); each gene has different functions. MITF is involved in neural crest melanocytes development as well as the pigmented retinal epithelium. TFEB is required for vascularization of the mouse placenta. TFE3 is involved in B cell function. TFEC regulates gene expression in macrophages. The MITF subfamily proteins can form homodimers or heterodimers with each other but not with other bHLH or bHLHzip proteins. Pssm-ID: 381393 [Multi-domain] Cd Length: 58 Bit Score: 42.63 E-value: 5.56e-06
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| bHLH_dnHLH_ID | cd19684 | basic helix-loop-helix (bHLH) domain found in the DNA-binding protein inhibitor (ID) family; ... |
157-193 | 1.22e-05 | ||
basic helix-loop-helix (bHLH) domain found in the DNA-binding protein inhibitor (ID) family; The ID family includes a dominant negative group of helix-loop-helix (dnHLH) proteins, ID1-4, that are negative regulators of bHLH transcription factors. They contain the HLH-dimerization domain but lack the basic domain necessary for DNA-binding. ID proteins inhibit binding to DNA and transcriptional transactivation by heterodimerization with bHLH proteins. They also interact with many non-bHLH proteins in complex networks. ID proteins have been implicated in regulating gene expression as well as cell-cycle progression. Whereas ID-1, ID-2 and ID-3, are generally considered as tumor promoters, ID4 on the contrary has emerged as a tumor suppressor. Pssm-ID: 381527 Cd Length: 47 Bit Score: 41.49 E-value: 1.22e-05
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| bHLH_TS_OLIG | cd11429 | basic helix-loop-helix (bHLH) domain found in Oligodendrocyte lineage genes (OLIG) family of ... |
146-202 | 2.52e-05 | ||
basic helix-loop-helix (bHLH) domain found in Oligodendrocyte lineage genes (OLIG) family of transcription factors; The OLIG family includes three bHLH transcription factors, Oligo1-3, which are expressed in both the developing and mature central nervous system. Oligo1 and Oligo2 are expressed in a nervous tissue-specific manner, but Oligo3 is found mainly in non-neural tissues. Oligo (also known as Olig) have key roles in the specification of motor neurons, dorsal interneurons, and oligodendrocytes. Oligo1, also termed Class B basic helix-loop-helix protein 6 (bHLHb6), or Class E basic helix-loop-helix protein 21 (bHLHe21), promotes formation and maturation of oligodendrocytes, especially within the brain. Oligo2, also termed Class B basic helix-loop-helix protein 1 (bHLHb1), or Class E basic helix-loop-helix protein 19 (bHLHe19), or protein kinase C-binding protein 2, or protein kinase C-binding protein RACK17, is required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. It cooperates with OLIG1 to establish the MN progenitors (pMN) domain of the embryonic neural tube. Oligo3, also termed Class B basic helix-loop-helix protein 7 (bHLHb7), or Class E basic helix-loop-helix protein 20 (bHLHe20), is expressed in the ventricular zone of the dorsal alar plate of the hindbrain and involved in regulating the development of dorsal and ventral spinal cord. It may determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons. This family also includes two OLIG-related bHLH transcription factors, bHLHe22 and bHLHe23. bHLHe22, also termed Class B basic helix-loop-helix protein 5 (bHLHb5), or trinucleotide repeat-containing gene 20 protein, is a neural-specific transcriptional repressor that is expressed in both excitatory (unipolar brush cells) and inhibitory neurons (cartwheel cells) of the dorsal cochlear nucleus (DCN) during development. It is important for the proper development and/or survival of a number of neural cell types. bHLHe23, also termed Class B basic helix-loop-helix protein 4 (bHLHb4), is expressed in rod bipolar cells and is required for rod bipolar cell maturation. bHLHe23 have roles in spinal interneuron differentiation by mechanisms linked to the Notch signaling pathway. It modulates the expression of genes required for the differentiation and/or maintenance of pancreatic and neuronal cell types. Pssm-ID: 381435 Cd Length: 61 Bit Score: 40.87 E-value: 2.52e-05
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| bHLH_TS_Mesp | cd18938 | basic helix-loop-helix (bHLH) domain found in the mesoderm posterior protein (Mesp) family; ... |
145-201 | 3.51e-05 | ||
basic helix-loop-helix (bHLH) domain found in the mesoderm posterior protein (Mesp) family; Mesp, a bHLH tissue specific transcription factor, acts as a key regulator of the cardiovascular transcriptional network by inducing directly and/or indirectly the expression of the majority of key cardiovascular transcription factors. The Mesp family includes two bHLH transcription factors, Mesp1 and Mesp2. Mesp1, also termed Class C basic helix-loop-helix protein 5 (bHLHc5), promotes cardiovascular differentiation during embryonic development and embryonic stem cell differentiation. Mesp2, also termed Class C basic helix-loop-helix protein 6 (bHLHc6), plays an important role in somitogenesis. Pssm-ID: 381508 [Multi-domain] Cd Length: 65 Bit Score: 40.65 E-value: 3.51e-05
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| bHLHzip_SREBP | cd11394 | basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding ... |
140-198 | 8.54e-05 | ||
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding protein (SREBP) family; The SREBP family includes SREBP1 and SREBP2, which are bHLHzip transcriptional activator of genes encoding proteins essential for cholesterol biosynthesis/uptake and fatty acid biosynthesis. SREBP1 and SREBP2 are principally found in the liver and in adipocytes and made up of an N-terminal transcription factor portion (composed of an activation domain, a bHLHzip domain, and a nuclear localization signal), a hydrophobic region containing two membrane spanning regions, and a C-terminal regulatory segment. They recognize a symmetric sterol regulatory element (TCACNCCAC) instead of E-box. Pssm-ID: 381400 [Multi-domain] Cd Length: 73 Bit Score: 39.95 E-value: 8.54e-05
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| bHLH_E-protein_E47-like | cd18943 | basic helix-loop-helix (bHLH) domain found in transcription factor E47 and similar proteins; ... |
145-207 | 1.29e-04 | ||
basic helix-loop-helix (bHLH) domain found in transcription factor E47 and similar proteins; E47 is a class I bHLH transcriptional regulator that forms heterodimers with class II bHLH proteins to regulate distinct differentiation pathways. Its homodimers regulate B lymphocytes development. Pssm-ID: 381513 Cd Length: 74 Bit Score: 39.26 E-value: 1.29e-04
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| bHLH_TS_bHLHe22_bHLHb5 | cd18954 | basic helix-loop-helix (bHLH) domain found in Class E basic helix-loop-helix protein 22 ... |
146-193 | 1.42e-04 | ||
basic helix-loop-helix (bHLH) domain found in Class E basic helix-loop-helix protein 22 (bHLHe22) and similar proteins; bHLHe22, also termed Class B basic helix-loop-helix protein 5 (bHLHb5), or trinucleotide repeat-containing gene 20 protein, is an OLIG-related bHLH neural-specific transcriptional repressor that is expressed in both excitatory (unipolar brush cells) and inhibitory neurons (cartwheel cells) of the dorsal cochlear nucleus (DCN) during development. It is important for the proper development and/or survival of a number of neural cell types. Pssm-ID: 381524 Cd Length: 70 Bit Score: 39.16 E-value: 1.42e-04
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| bHLH_TS_dMYOD_like | cd19699 | basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster myogenic-determination ... |
145-200 | 2.08e-04 | ||
basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster myogenic-determination protein (dMYOD) and similar proteins; dMYOD, also termed protein nautilus, or Myd, may play an important role in the early development of muscle in Drosophila. Pssm-ID: 381542 Cd Length: 56 Bit Score: 38.29 E-value: 2.08e-04
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| bHLH_dnHLH_ID2 | cd19692 | basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID2 and similar ... |
159-193 | 2.26e-04 | ||
basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID2 and similar proteins; ID2, also termed Class B basic helix-loop-helix protein 26 (bHLHb26), or inhibitor of DNA binding 2, or inhibitor of differentiation 2, is a dominant negative helix-loop-helix (dnHLH) transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the bHLH transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. It has been implicated in the regulation of cell proliferation and differentiation in myogenesis, neurogenesis, and/or hematopoiesis. Pssm-ID: 381535 Cd Length: 66 Bit Score: 38.46 E-value: 2.26e-04
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| bHLH_E-protein_E2A_TCF3 | cd18944 | basic helix-loop-helix (bHLH) domain found in transcription factor E2-alpha (E2A) and similar ... |
145-207 | 2.99e-04 | ||
basic helix-loop-helix (bHLH) domain found in transcription factor E2-alpha (E2A) and similar proteins; E2A, also termed Class B basic helix-loop-helix protein 21 (bHLHb21), or immunoglobulin enhancer-binding factor E12/E47, or immunoglobulin transcription factor 1, or Kappa-E2-binding factor, or transcription factor 3 (TCF-3), or transcription factor ITF-1, is a bHLH transcriptional regulator involved in the initiation of neuronal differentiation. Pssm-ID: 381514 Cd Length: 74 Bit Score: 38.47 E-value: 2.99e-04
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| bHLH_AtbHLH_like | cd11393 | basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana genes coding transcription ... |
150-196 | 3.04e-04 | ||
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana genes coding transcription factors and similar proteins; bHLH proteins are the second largest class of plant transcription factors that regulate transcription of genes that are involve in many essential physiological and developmental process. bHLH proteins are transcriptional regulators that are found in organisms from yeast to humans. The Arabidopsis bHLH proteins that have been characterized so far have roles in regulation of fruit dehiscence, cell development (carpel, anther and epidermal), phytochrome signaling, flavonoid biosynthesis, hormone signaling and stress responses. Pssm-ID: 381399 [Multi-domain] Cd Length: 53 Bit Score: 37.55 E-value: 3.04e-04
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| bHLH_TS_MRF | cd11411 | basic helix-loop-helix (bHLH) domain found in myogenic regulatory factor (MRF) family; MRFs ... |
145-200 | 3.20e-04 | ||
basic helix-loop-helix (bHLH) domain found in myogenic regulatory factor (MRF) family; MRFs are a family of muscle-specific bHLH transcription proteins (MyoD, Myf5, Mrf4 and MyoG) that plays an essential role in regulating skeletal muscle development and growth. MRFs are capable of binding to E-box motifs as a heterodimer with E-proteins to regulate transcription expression. Pssm-ID: 381417 Cd Length: 56 Bit Score: 37.90 E-value: 3.20e-04
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| bHLHzip_MGA_like | cd19682 | basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) ... |
150-198 | 3.63e-04 | ||
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) family; The MGA family includes MGA, Schizosaccharomyces pombe ESC1 (spESC1) and similar proteins. MGA, also termed MAX dimerization protein 5 (MAD5), is a dual specificity T-box/ bHLHzip transcription factor that regulates the expression of both Max-network and T-box family target genes. It contains a Myc-like bHLHZip motif and requires heterodimerization with Max for binding to the preferred Myc-Max-binding site CACGTG. In addition to the bHLHZip domain, MGA harbors a second DNA-binding domain, the T-box or T-domain. It thus binds the preferred Brachyury-binding sequence and represses transcription of reporter genes containing promoter-proximal Brachyury-binding sites. spESC1 is a bHLHzip protein with homology to human MyoD and Myf-5 myogenic differentiation inducers. It is involved in the sexual differentiation process. Pssm-ID: 381525 [Multi-domain] Cd Length: 65 Bit Score: 38.02 E-value: 3.63e-04
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| bHLH_TS_OLIG2_like | cd19725 | basic helix-loop-helix (bHLH) domain found in oligodendrocyte transcription factors, Oligo2, ... |
146-196 | 5.49e-04 | ||
basic helix-loop-helix (bHLH) domain found in oligodendrocyte transcription factors, Oligo2, Oligo3 and similar proteins; The family includes two bHLH transcription factors, Oligo2 and Oligo3. Oligo2, also termed Class B basic helix-loop-helix protein 1 (bHLHb1), or Class E basic helix-loop-helix protein 19 (bHLHe19), or protein kinase C-binding protein 2, or protein kinase C-binding protein RACK17, is required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. It cooperates with OLIG1 to establish the MN progenitors (pMN) domain of the embryonic neural tube. Oligo3, also termed Class B basic helix-loop-helix protein 7 (bHLHb7), or Class E basic helix-loop-helix protein 20 (bHLHe20), is expressed in the ventricular zone of the dorsal alar plate of the hindbrain and involved in regulating the development of dorsal and ventral spinal cord. It may determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons. Pssm-ID: 381568 Cd Length: 63 Bit Score: 37.22 E-value: 5.49e-04
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| bHLH_dnHLH_ID1 | cd19691 | basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID1 and similar ... |
158-193 | 5.99e-04 | ||
basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID1 and similar proteins; ID1, also termed Class B basic helix-loop-helix protein 24 (bHLHb24), or inhibitor of DNA binding 1, or inhibitor of differentiation 1, is a dominant negative helix-loop-helix (dnHLH) transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the bHLH transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. ID1 interferes with centrosomal function. It has been implicated in the regulation of cell proliferation and differentiation in myogenesis, neurogenesis, and/or hematopoiesis. Pssm-ID: 381534 Cd Length: 52 Bit Score: 37.09 E-value: 5.99e-04
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| bHLH_ScINO2_like | cd11388 | basic helix-loop-helix (bHLH) domain found in Saccharomyces cerevisiae protein INO2 and ... |
145-198 | 1.12e-03 | ||
basic helix-loop-helix (bHLH) domain found in Saccharomyces cerevisiae protein INO2 and similar proteins; INO2 is a positive regulatory factor required for depression of the co-regulated phospholipid biosynthetic enzymes in Saccharomyces cerevisiae. It is also involved in the expression of ITR1. Pssm-ID: 381394 Cd Length: 68 Bit Score: 36.56 E-value: 1.12e-03
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| bHLHzip_USF3 | cd18910 | basic Helix-Loop-Helix-zipper (bHLHzip) domain found in basic helix-loop-helix ... |
141-196 | 1.65e-03 | ||
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in basic helix-loop-helix domain-containing protein USF3 and similar proteins; USF3, also termed upstream transcription factor 3, is a bHLHzip protein that is involved in the negative regulation of epithelial-mesenchymal transition, the process by which epithelial cells lose their polarity and adhesion properties to become mesenchymal cells with enhanced migration and invasive properties. Pssm-ID: 381480 Cd Length: 65 Bit Score: 36.12 E-value: 1.65e-03
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| bHLH_TS_MYOG_Myf4 | cd18935 | basic helix-loop-helix (bHLH) domain found in myogenin (MYOG) and similar proteins; MYOG, also ... |
145-200 | 1.75e-03 | ||
basic helix-loop-helix (bHLH) domain found in myogenin (MYOG) and similar proteins; MYOG, also termed Class C basic helix-loop-helix protein 3 (bHLHc3), or myogenic factor 4 (Myf-4), is a bHLH transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Pssm-ID: 381505 Cd Length: 59 Bit Score: 35.78 E-value: 1.75e-03
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| bHLH_TS_bHLHe22_like | cd11468 | basic helix-loop-helix (bHLH) domain found in Class E basic helix-loop-helix protein bHLHe22, ... |
146-200 | 1.75e-03 | ||
basic helix-loop-helix (bHLH) domain found in Class E basic helix-loop-helix protein bHLHe22, bHLHe23 and similar proteins; The family includes two OLIG-related bHLH transcription factors, bHLHe22 and bHLHe23. bHLHe22, also termed Class B basic helix-loop-helix protein 5 (bHLHb5), or trinucleotide repeat-containing gene 20 protein, is a neural-specific transcriptional repressor that is expressed in both excitatory (unipolar brush cells) and inhibitory neurons (cartwheel cells) of the dorsal cochlear nucleus (DCN) during development. It is important for the proper development and/or survival of a number of neural cell types. bHLHe23, also termed Class B basic helix-loop-helix protein 4 (bHLHb4), is expressed in rod bipolar cells and is required for rod bipolar cell maturation. bHLHe23 have roles in spinal interneuron differentiation by mechanisms linked to the Notch signaling pathway. It modulates the expression of genes required for the differentiation and/or maintenance of pancreatic and neuronal cell types. Pssm-ID: 381474 Cd Length: 62 Bit Score: 35.97 E-value: 1.75e-03
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| bHLH-O_HERP_like | cd11389 | basic helix-loop-helix-orange (bHLH-O) domain found in hairy and enhancer of split (HES) ... |
153-196 | 1.81e-03 | ||
basic helix-loop-helix-orange (bHLH-O) domain found in hairy and enhancer of split (HES)-related repressor protein (HERP)-like family; The HERP-like family includes bHLH-O transcriptional regulators that are related to the Drosophila hairy and Enhancer-of-split proteins. They contain a basic helix-loop-helix (bHLH) domain with an invariant glycine residue in its basic region, an orange domain in the central region and YXXW sequence motif at its C-terminal region. HERP proteins (HEY1, HEY2 and HEYL) act as downstream effectors of Notch signaling. They are involved in cardiovascular development and have roles in somitogenesis, myogenesis and gliogenesis. Hairy and enhancer of split-related protein HELT is a transcriptional repressor expressed in the developing central nervous system. It binds preferentially to the canonical E box sequence 5'-CACGCG-3' and regulates neuronal differentiation and/or identity. Differentially expressed in chondrocytes proteins, DEC1 and DEC2, are widely expressed in both embryonic and adult tissues and have been implicated in apoptosis, cell proliferation, and circadian rhythms, as well as malignancy in various cancers. Drosophila melanogaster protein clockwork orange (Cwo) is also included in this family. It is involved in the regulation of Drosophila circadian rhythms. It functions as both an activator and a repressor of clock gene expression. Pssm-ID: 381395 [Multi-domain] Cd Length: 55 Bit Score: 35.76 E-value: 1.81e-03
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| bHLHzip_Myc | cd11400 | basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the Myc family; The Myc family is a ... |
145-198 | 2.03e-03 | ||
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the Myc family; The Myc family is a member of the bHLHzip family of transcription factors that play important roles in the control of normal cell proliferation, growth, survival and differentiation. All Myc isoforms contain two independently functioning polypeptide chain regions: N-terminal transactivating residues and a C-terminal bHLHzip segment. The bHLHzip family of bHLH transcription factors are characterized by a highly conserved N-terminal basic region that may bind DNA at a consensus hexanucleotide sequence known as the E-box (CANNTG) followed by HLH and leucine zipper motifs that may interact with other proteins to form homo- and heterodimers. Myc heterodimerizes with Max enabling specific binding to E-box DNA sequences in the promoters of target genes. The Myc proto-oncoprotein family includes at least five different functional members: c-, N-, L-, S- and B-Myc (which is lacking the bHLH domain). Pssm-ID: 381406 [Multi-domain] Cd Length: 80 Bit Score: 35.99 E-value: 2.03e-03
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| bHLHzip_SREBP_like | cd11395 | basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding ... |
139-198 | 2.44e-03 | ||
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding protein (SREBP) family and similar proteins; The SREBP family includes SREBP1 and SREBP2, which are bHLHzip transcriptional activator of genes encoding proteins essential for cholesterol biosynthesis/uptake and fatty acid biosynthesis. SREBP1 and SREBP2 are principally found in the liver and in adipocytes and made up of an N-terminal transcription factor portion (composed of an activation domain, a bHLHzip domain, and a nuclear localization signal), a hydrophobic region containing two membrane spanning regions, and a C-terminal regulatory segment. They recognize a symmetric sterol regulatory element (TCACNCCAC) instead of E-box. The family also includes Saccharomyces cerevisiae transcription factor HMS1 (also termed high-copy MEP suppressor protein 1) and serine-rich protein TYE7. HMS1 is a putative bHLHzip transcription factor involved in exit from mitosis and pseudohyphal differentiation. TYE7, also termed basic-helix-loop-helix protein SGC1, is a putative bHLHzip transcription activator required for Ty1-mediated glycolytic gene expression. TYE7 N-terminal is extremely rich in serine residues. It binds DNA on E-box motifs, 5'-CANNTG-3'. TYE7 is not essential for growth. Pssm-ID: 381401 [Multi-domain] Cd Length: 87 Bit Score: 36.16 E-value: 2.44e-03
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| bHLH_PAS | cd11391 | basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain family; bHLH-PAS domain has been found ... |
149-193 | 3.15e-03 | ||
basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain family; bHLH-PAS domain has been found in a large group of bHLH transcription regulators that are involved in gene expression responding to environmental change and controlling aspects of neural development, including proteins from aryl hydrocarbon receptor nuclear translocator (ARNT) family, hypoxia-inducible factor (HIF) family, aryl hydrocarbon receptor (AhR) family, neuronal PAS domain-containing protein (NPAS) family, Circadian locomotor output cycles protein kaput (CLOCK)-like family, and single-minded (SIM) family. bHLH-PAS transcriptional regulatory factors have a bHLH DNA-binding domain followed by two PAS domains and a C-terminal activation or repression domain. bHLH-PAS family members can be divided into class I and class II based on their dimerization partner. bHLH-PAS class I factors include AhR, HIF and SIM. The best characterized bHLH-PAS Class II protein is the ubiquitous ARNT. Some members of bHLH-PAS family act as transcriptional coactivators (such as NCoA) that lack the ability to dimerize and bind DNA. Pssm-ID: 381397 [Multi-domain] Cd Length: 55 Bit Score: 34.86 E-value: 3.15e-03
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| bHLH_TS_bHLHa9 | cd18912 | basic helix-loop-helix (bHLH) domain found in Class A basic helix-loop-helix protein 9 (bHLHa9) ... |
144-196 | 3.74e-03 | ||
basic helix-loop-helix (bHLH) domain found in Class A basic helix-loop-helix protein 9 (bHLHa9) and similar proteins; bHLHa9, also termed Class F basic helix-loop-helix factor 42 (bHLHf42), is a bHLH transcription factor that plays an essential role in limb development. Pssm-ID: 381482 Cd Length: 63 Bit Score: 34.92 E-value: 3.74e-03
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| bHLH_TS_MRF4_Myf6 | cd18934 | basic helix-loop-helix (bHLH) domain found in muscle-specific regulatory factor 4 (MRF4) and ... |
145-200 | 4.19e-03 | ||
basic helix-loop-helix (bHLH) domain found in muscle-specific regulatory factor 4 (MRF4) and similar proteins; MRF4, also termed Class C basic helix-loop-helix protein 4 (bHLHc4), or myogenic factor 6 (Myf-6), is a bHLH transcription factor associated with myogenesis. It plays a role in skeletal muscle differentiation. Pssm-ID: 381504 Cd Length: 64 Bit Score: 35.04 E-value: 4.19e-03
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| bHLH_E-protein_Da_like | cd11467 | basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster protein daughterless (Da) ... |
145-207 | 6.04e-03 | ||
basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster protein daughterless (Da) and similar proteins; Da is a nuclear bHLH transcription factor that is a sole E protein ortholog essential for both neurogenesis and sex determination in Drosophila. Da is expressed in a broad range of tissues and is involved in diverse developmental processes such as oogenesis, sex determination and neurogenesis depending on its bHLH-binding partners. Da and achaete-scute complex (AS-C) form heterodimers that act as transcriptional activators of neural cell fates and are involved in sex determination. Pssm-ID: 381473 Cd Length: 70 Bit Score: 34.62 E-value: 6.04e-03
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| bHLHzip_SREBP1 | cd18921 | basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding ... |
140-196 | 6.08e-03 | ||
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding protein 1 (SREBP1) and similar proteins; SREBP1, also termed Class D basic helix-loop-helix protein 1 (bHLHd1), or sterol regulatory element-binding transcription factor 1 (SREBF1), is a member of a family of bHLHzip transcription factors that recognize sterol regulatory element 1 (SRE-1). It acts as a transcriptional activator required for lipid homeostasis. It may control transcription of the low-density lipoprotein receptor gene as well as the fatty acid. SREBP1 has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). Pssm-ID: 381491 Cd Length: 75 Bit Score: 34.87 E-value: 6.08e-03
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| bHLH_AtORG2_like | cd18914 | basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana OBP3-responsive gene 2 ... |
145-196 | 7.94e-03 | ||
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana OBP3-responsive gene 2 (ORG2), 3 (ORG3) and similar proteins; The family includes ORG2 (also termed AtbHLH38, or EN 8) and ORG3 (also termed AtbHLH39, or EN 9), both of which act as bHLH transcription factors. Pssm-ID: 381484 [Multi-domain] Cd Length: 77 Bit Score: 34.59 E-value: 7.94e-03
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| bHLH-O_HEYL | cd11447 | basic helix-loop-helix-orange (bHLH-O) domain found in hairy/enhancer-of-split related with ... |
153-196 | 9.23e-03 | ||
basic helix-loop-helix-orange (bHLH-O) domain found in hairy/enhancer-of-split related with YRPW motif-like protein (HEYL) and similar proteins; HEYL, also termed Class B basic helix-loop-helix protein 33 (bHLHb33), or hairy-related transcription factor 3 (HRT-3), is a bHLH-O transcriptional repressor that is strongly expressed in the presomitic mesoderm, the somites, the peripheral nervous system and smooth muscle of all arteries and is a downstream effector of the Notch and transforming growth factor-beta pathways. It promotes neuronal differentiation by activating proneural genes and inhibiting other hairy and enhancer of split (HES) and hairy/enhancer-of-split related with YRPW motif protein (HEY) proteins. HEYL also functions as a tumor suppressor involved in the progression of human cancers. Pssm-ID: 381453 [Multi-domain] Cd Length: 74 Bit Score: 34.30 E-value: 9.23e-03
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