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Conserved domains on  [gi|568918730|ref|XP_006500399|]
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uncharacterized protein LOC75721 isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF3496 super family cl13439
Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. ...
 594-674 4.69e-09

Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 110 amino acids in length.


The actual alignment was detected with superfamily member pfam12001:

Pssm-ID: 463425 [Multi-domain]  Cd Length: 109  Bit Score: 55.06  E-value: 4.69e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918730   594 MSQLELRIQHLEREFSEMKTRTWE-NGVVLENYVKLHQ---------SHKLMETESKMKEVMSQFAMLTQHNTALLNLLS 663
Cdd:pfam12001    1 RSQMELRIKDLESELSKMKTSQEDsNKIELEKYKQLYLeelkvrkslSNKLNKTNERLAEVSTKLLVEKQQNRSLLSTLT 80

                           90
                   ....*....|.
gi 568918730   664 SVFASECPCKG 674
Cdd:pfam12001   81 TRPVLESPCVG 91
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 400-566 3.49e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 41.58  E-value: 3.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918730   400 IVERNQNHSELLIEKSKNK---RNQGHRVMKKPGETEKAKLQLRCRREEQQLDL------LDVGSPEKQDMQQRNP--DG 468
Cdd:TIGR02168  286 LQKELYALANEISRLEQQKqilRERLANLERQLEELEAQLEELESKLDELAEELaeleekLEELKEELESLEAELEelEA 365

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918730   469 WYEEMKKELTEKDPQHGREKQ---QLELRLRAQDMELQHLRNDINKLQEAQHPETE--AGHGDSMTKGHLQKVEHEVFKL 543
Cdd:TIGR02168  366 ELEELESRLEELEEQLETLRSkvaQLELQIASLNNEIERLEARLERLEDRRERLQQeiEELLKKLEEAELKELQAELEEL 445

                          170       180
                   ....*....|....*....|...
gi 568918730   544 VETIKKQSETIEQLERKLANEDK 566
Cdd:TIGR02168  446 EEELEELQEELERLEEALEELRE 468
 
Name Accession Description Interval E-value
DUF3496 pfam12001
Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. ...
 594-674 4.69e-09

Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 110 amino acids in length.


Pssm-ID: 463425 [Multi-domain]  Cd Length: 109  Bit Score: 55.06  E-value: 4.69e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918730   594 MSQLELRIQHLEREFSEMKTRTWE-NGVVLENYVKLHQ---------SHKLMETESKMKEVMSQFAMLTQHNTALLNLLS 663
Cdd:pfam12001    1 RSQMELRIKDLESELSKMKTSQEDsNKIELEKYKQLYLeelkvrkslSNKLNKTNERLAEVSTKLLVEKQQNRSLLSTLT 80

                           90
                   ....*....|.
gi 568918730   664 SVFASECPCKG 674
Cdd:pfam12001   81 TRPVLESPCVG 91
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 400-566 3.49e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 41.58  E-value: 3.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918730   400 IVERNQNHSELLIEKSKNK---RNQGHRVMKKPGETEKAKLQLRCRREEQQLDL------LDVGSPEKQDMQQRNP--DG 468
Cdd:TIGR02168  286 LQKELYALANEISRLEQQKqilRERLANLERQLEELEAQLEELESKLDELAEELaeleekLEELKEELESLEAELEelEA 365

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918730   469 WYEEMKKELTEKDPQHGREKQ---QLELRLRAQDMELQHLRNDINKLQEAQHPETE--AGHGDSMTKGHLQKVEHEVFKL 543
Cdd:TIGR02168  366 ELEELESRLEELEEQLETLRSkvaQLELQIASLNNEIERLEARLERLEDRRERLQQeiEELLKKLEEAELKELQAELEEL 445

                          170       180
                   ....*....|....*....|...
gi 568918730   544 VETIKKQSETIEQLERKLANEDK 566
Cdd:TIGR02168  446 EEELEELQEELERLEEALEELRE 468
 
Name Accession Description Interval E-value
DUF3496 pfam12001
Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. ...
 594-674 4.69e-09

Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 110 amino acids in length.


Pssm-ID: 463425 [Multi-domain]  Cd Length: 109  Bit Score: 55.06  E-value: 4.69e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918730   594 MSQLELRIQHLEREFSEMKTRTWE-NGVVLENYVKLHQ---------SHKLMETESKMKEVMSQFAMLTQHNTALLNLLS 663
Cdd:pfam12001    1 RSQMELRIKDLESELSKMKTSQEDsNKIELEKYKQLYLeelkvrkslSNKLNKTNERLAEVSTKLLVEKQQNRSLLSTLT 80

                           90
                   ....*....|.
gi 568918730   664 SVFASECPCKG 674
Cdd:pfam12001   81 TRPVLESPCVG 91
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 400-566 3.49e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 41.58  E-value: 3.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918730   400 IVERNQNHSELLIEKSKNK---RNQGHRVMKKPGETEKAKLQLRCRREEQQLDL------LDVGSPEKQDMQQRNP--DG 468
Cdd:TIGR02168  286 LQKELYALANEISRLEQQKqilRERLANLERQLEELEAQLEELESKLDELAEELaeleekLEELKEELESLEAELEelEA 365

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918730   469 WYEEMKKELTEKDPQHGREKQ---QLELRLRAQDMELQHLRNDINKLQEAQHPETE--AGHGDSMTKGHLQKVEHEVFKL 543
Cdd:TIGR02168  366 ELEELESRLEELEEQLETLRSkvaQLELQIASLNNEIERLEARLERLEDRRERLQQeiEELLKKLEEAELKELQAELEEL 445

                          170       180
                   ....*....|....*....|...
gi 568918730   544 VETIKKQSETIEQLERKLANEDK 566
Cdd:TIGR02168  446 EEELEELQEELERLEEALEELRE 468
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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