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Conserved domains on  [gi|568922474|ref|XP_006501391|]
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FH2 domain-containing protein 1 isoform X1 [Mus musculus]

Protein Classification

FH2 domain-containing protein( domain architecture ID 13671889)

FH2 domain-containing protein; FH2 domain-containing protein similar to formin homology proteins that control rearrangements of the actin cytoskeleton, especially in the context of cytokinesis and cell polarization; FH2 domain-containing protein; FH2 domain-containing protein similar to formin homology proteins that control rearrangements of the actin cytoskeleton, especially in the context of cytokinesis and cell polarization

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FH2 pfam02181
Formin Homology 2 Domain;
94-458 7.41e-116

Formin Homology 2 Domain;


:

Pssm-ID: 396655  Cd Length: 372  Bit Score: 363.90  E-value: 7.41e-116
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474    94 KKKRMRSFFWKTIPEEQVRGktNIWTLAAKQQHQYQIDKKTIEELFGQQEDTSKASLPKRGGALNSSfrdaREEVTVLDA 173
Cdd:pfam02181    7 PKKKLKPLHWDKVRPSQDRG--TVWDKLDDESFELDGDLSELEELFSAKAKTKKNKKSEDKSSSKKK----PKEVSLLDP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474   174 KRSMNIGIFLKQFKKSPQSIVEDIYQGKSEHYGSETLREILKLLPESEEVKKLKAFNGDVSKLSLADSFLHCLIQVPNYS 253
Cdd:pfam02181   81 KRAQNIAILLRKLKLPPEEIIQAILEGDEDALDLELLENLLKMAPTKEELKKLKEYKGDPSELGRAEQFLLELSKIPRLE 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474   254 LRIEAMVLKKEFLPSCSSLFKDIRTLRAATKELMLCEELHSILHLVLQAGNIMNAGGYAGNAVGFKLSSLLKLADTKANK 333
Cdd:pfam02181  161 ARLRALLFKSTFEEEIEELKPSLEALEAASEELRNSRKFKKLLELILALGNYMNDGTRRGQAKGFKLSSLLKLSDTKSTD 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474   334 PGMNLLHFVAQEAQKQDAILLNFSEKLQHVQETSRLSLDITEAELHSLFVRTKSLQENIQL-------DQELCQQMEDFL 406
Cdd:pfam02181  241 NKTTLLHYLVKIIREKFPEVLDFSSELSHVKKAAKVNLEQLEKDVKQLERGLKKLERELELsaldehpDDKFREVLKEFL 320

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|..
gi 568922474   407 QFAVEKLAELELWKRELQGEAHTLIDFFCEDKETMKLDECFQIFRDFCTRFN 458
Cdd:pfam02181  321 KSAEEKLDKLESLLREALELFKELVEYFGEDPKETSPEEFFKILRDFLKEFK 372
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 823-1064 1.15e-10

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 66.50  E-value: 1.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  823 PPGEVPAPKSSKSELSCQGGLPKDRPSRGKDAIAPKRnsfkeasvgASKPVSARRsQGVTTKPVRTLNSSENEHMRKVV- 901
Cdd:PHA03247 2624 PDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGR---------VSRPRRARR-LGRAAQASSPPQRPRRRAARPTVg 2693

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  902 PISKSSRGAGPWKRPEPTPKATPRETPSSTDTPLSRRSSVRGTSDTSPRRPqvsgsgAEEPRLPRSSGSISGRPGKDAPL 981
Cdd:PHA03247 2694 SLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAV------PAGPATPGGPARPARPPTTAGPP 2767

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  982 QPRASfRKPSAKPLRNIPRQKPEENKVSSPNSPDPESPKEEPKA--PQATGVSRALPPIPSFARNTVASSSRSLRTDAPP 1059
Cdd:PHA03247 2768 APAPP-AAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAvlAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPP 2846


                  ....*
gi 568922474 1060 AARTT 1064
Cdd:PHA03247 2847 PPSLP 2851
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 524-981 1.29e-07

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 56.33  E-value: 1.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  524 PNSPSYRPPNTRRSRLSLGISADRELLTFLESATSSPEDPNKFNSLPRSSPRQARPTIAWMEPREQQSHGPNFTHEPQAS 603
Cdd:PHA03307   25 PATPGDAADDLLSGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREG 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  604 KIQEKAPPPAwqnqLPTTWREEPASPLPLAGRSRPSLRKRnSEPVGLGPTQSPPLLPLDLG-VREHELVTGLTQFDLQSP 682
Cdd:PHA03307  105 SPTPPGPSSP----DPPPPTPPPASPPPSPAPDLSEMLRP-VGSPGPPPAASPPAAGASPAaVASDAASSRQAALPLSSP 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  683 KSLEEgsqltlndfCPTKLPSPGDRSSQPFAAGGDSLPPKDTDTQEVLSPAGEDDRTISDEPSSEALVSvVVTDTEDKDA 762
Cdd:PHA03307  180 EETAR---------APSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDS-SSSESSGCGW 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  763 GPLlyvsdttdcSLTLDCSEGMDSRAGGDKQEEEKEGDGSVSSGAGEAGssqvssnsvsSPPGEVPAPKSSKSelscqGG 842
Cdd:PHA03307  250 GPE---------NECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSS----------SPRERSPSPSPSSP-----GS 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  843 LPKDRPSRGKDAIAPKRnsfkEASVGASKPVSA-RRSQGVTTKPvrtlnssenEHMRKVVPISKSSRGAGPWKRPEPTPK 921
Cdd:PHA03307  306 GPAPSSPRASSSSSSSR----ESSSSSTSSSSEsSRGAAVSPGP---------SPSRSPSPSRPPPPADPSSPRKRPRPS 372

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568922474  922 ATPRETPSSTDTPLSRRSS-----VRGTSDTSPRRPqvsgsGAEEPRLPRSSGSISGRPGKDAPL 981
Cdd:PHA03307  373 RAPSSPAASAGRPTRRRARaavagRARRRDATGRFP-----AGRPRPSPLDAGAASGAFYARYPL 432
 
Name Accession Description Interval E-value
FH2 pfam02181
Formin Homology 2 Domain;
94-458 7.41e-116

Formin Homology 2 Domain;


Pssm-ID: 396655  Cd Length: 372  Bit Score: 363.90  E-value: 7.41e-116
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474    94 KKKRMRSFFWKTIPEEQVRGktNIWTLAAKQQHQYQIDKKTIEELFGQQEDTSKASLPKRGGALNSSfrdaREEVTVLDA 173
Cdd:pfam02181    7 PKKKLKPLHWDKVRPSQDRG--TVWDKLDDESFELDGDLSELEELFSAKAKTKKNKKSEDKSSSKKK----PKEVSLLDP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474   174 KRSMNIGIFLKQFKKSPQSIVEDIYQGKSEHYGSETLREILKLLPESEEVKKLKAFNGDVSKLSLADSFLHCLIQVPNYS 253
Cdd:pfam02181   81 KRAQNIAILLRKLKLPPEEIIQAILEGDEDALDLELLENLLKMAPTKEELKKLKEYKGDPSELGRAEQFLLELSKIPRLE 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474   254 LRIEAMVLKKEFLPSCSSLFKDIRTLRAATKELMLCEELHSILHLVLQAGNIMNAGGYAGNAVGFKLSSLLKLADTKANK 333
Cdd:pfam02181  161 ARLRALLFKSTFEEEIEELKPSLEALEAASEELRNSRKFKKLLELILALGNYMNDGTRRGQAKGFKLSSLLKLSDTKSTD 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474   334 PGMNLLHFVAQEAQKQDAILLNFSEKLQHVQETSRLSLDITEAELHSLFVRTKSLQENIQL-------DQELCQQMEDFL 406
Cdd:pfam02181  241 NKTTLLHYLVKIIREKFPEVLDFSSELSHVKKAAKVNLEQLEKDVKQLERGLKKLERELELsaldehpDDKFREVLKEFL 320

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|..
gi 568922474   407 QFAVEKLAELELWKRELQGEAHTLIDFFCEDKETMKLDECFQIFRDFCTRFN 458
Cdd:pfam02181  321 KSAEEKLDKLESLLREALELFKELVEYFGEDPKETSPEEFFKILRDFLKEFK 372
FH2 smart00498
Formin Homology 2 Domain; FH proteins control rearrangements of the actin cytoskeleton, ...
 95-487 4.38e-60

Formin Homology 2 Domain; FH proteins control rearrangements of the actin cytoskeleton, especially in the context of cytokinesis and cell polarisation. Members of this family have been found to interact with Rho-GTPases, profilin and other actin-assoziated proteins. These interactions are mediated by the proline-rich FH1 domain, usually located in front of FH2 (but not listed in SMART). Despite this cytosolic function, vertebrate formins have been assigned functions within the nucleus. A set of Formin-Binding Proteins (FBPs) has been shown to bind FH1 with their WW domain.


Pssm-ID: 214697 [Multi-domain]  Cd Length: 392  Bit Score: 211.44  E-value: 4.38e-60
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474     95 KKRMRSFFWKTIPEEQVRGktniwTLAAKQQHQYQIDKKTIEELFGQQEDTSKASLPKRGGALNSSfRDAREEVTVLDAK 174
Cdd:smart00498    7 KKKLKPLHWDKLNPSDLSG-----TVWDKIDEESEGDLDELEELFSAKEKTKSASKDVSEKKSILK-KKASQEFKILDPK 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474    175 RSMNIGIFLKQFKKSPQSIVEDIYQGKSEHYGSETLREILKLLPESEEVKKLKAFNG-DVSKLSLADSFLHCLIQVPNYS 253
Cdd:smart00498   81 RSQNLAILLRKLHMSYEEIKEAILEGDEDVLSVDLLEQLLKYAPTKEELKKLREYKEeDPEELARAEQFLLLISNIPYLE 160

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474    254 LRIEAMVLKKEFLPSCSSLFKDIRTLRAATKELMLCEELHSILHLVLQAGNIMNAGGYAGNAVGFKLSSLLKLADTKANK 333
Cdd:smart00498  161 ERLNALLFKANFEEEVEDLKPQIEKVEAACEELRESKKFRKLLELILAIGNYMNGGSRRGQAYGFKLSSLLKLSDVKSAD 240

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474    334 PGMNLLHFVAQEaqkqdaillnfseklqhvqetsrlsldITEAELHSLfvrtkSLQENiqLDQELCQQMEDFLQFAVEKL 413
Cdd:smart00498  241 NKTTLLHFLVKI---------------------------IRKKYLGGL-----SDPEN--LDDKFIEVMKPFLKAAKEKY 286

                           330       340       350       360       370       380       390
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568922474    414 AELELWKRELQGEAHTLIDFFCEDKETMKLDECFQIFRDFCTRFNKAVKDNHDREEQERKQLQRQKEMEQKRYS 487
Cdd:smart00498  287 DKLQKDLSDLKTRFEKLVEYYGEDPKDTSPEEFFKDFNEFLKEFSKAAEENIKKEEEEEERRKKLVKETTEYEQ 360
PHA03247 PHA03247
large tegument protein UL36; Provisional
 823-1064 1.15e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 66.50  E-value: 1.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  823 PPGEVPAPKSSKSELSCQGGLPKDRPSRGKDAIAPKRnsfkeasvgASKPVSARRsQGVTTKPVRTLNSSENEHMRKVV- 901
Cdd:PHA03247 2624 PDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGR---------VSRPRRARR-LGRAAQASSPPQRPRRRAARPTVg 2693

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  902 PISKSSRGAGPWKRPEPTPKATPRETPSSTDTPLSRRSSVRGTSDTSPRRPqvsgsgAEEPRLPRSSGSISGRPGKDAPL 981
Cdd:PHA03247 2694 SLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAV------PAGPATPGGPARPARPPTTAGPP 2767

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  982 QPRASfRKPSAKPLRNIPRQKPEENKVSSPNSPDPESPKEEPKA--PQATGVSRALPPIPSFARNTVASSSRSLRTDAPP 1059
Cdd:PHA03247 2768 APAPP-AAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAvlAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPP 2846


                  ....*
gi 568922474 1060 AARTT 1064
Cdd:PHA03247 2847 PPSLP 2851
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 524-981 1.29e-07

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 56.33  E-value: 1.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  524 PNSPSYRPPNTRRSRLSLGISADRELLTFLESATSSPEDPNKFNSLPRSSPRQARPTIAWMEPREQQSHGPNFTHEPQAS 603
Cdd:PHA03307   25 PATPGDAADDLLSGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREG 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  604 KIQEKAPPPAwqnqLPTTWREEPASPLPLAGRSRPSLRKRnSEPVGLGPTQSPPLLPLDLG-VREHELVTGLTQFDLQSP 682
Cdd:PHA03307  105 SPTPPGPSSP----DPPPPTPPPASPPPSPAPDLSEMLRP-VGSPGPPPAASPPAAGASPAaVASDAASSRQAALPLSSP 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  683 KSLEEgsqltlndfCPTKLPSPGDRSSQPFAAGGDSLPPKDTDTQEVLSPAGEDDRTISDEPSSEALVSvVVTDTEDKDA 762
Cdd:PHA03307  180 EETAR---------APSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDS-SSSESSGCGW 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  763 GPLlyvsdttdcSLTLDCSEGMDSRAGGDKQEEEKEGDGSVSSGAGEAGssqvssnsvsSPPGEVPAPKSSKSelscqGG 842
Cdd:PHA03307  250 GPE---------NECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSS----------SPRERSPSPSPSSP-----GS 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  843 LPKDRPSRGKDAIAPKRnsfkEASVGASKPVSA-RRSQGVTTKPvrtlnssenEHMRKVVPISKSSRGAGPWKRPEPTPK 921
Cdd:PHA03307  306 GPAPSSPRASSSSSSSR----ESSSSSTSSSSEsSRGAAVSPGP---------SPSRSPSPSRPPPPADPSSPRKRPRPS 372

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568922474  922 ATPRETPSSTDTPLSRRSS-----VRGTSDTSPRRPqvsgsGAEEPRLPRSSGSISGRPGKDAPL 981
Cdd:PHA03307  373 RAPSSPAASAGRPTRRRARaavagRARRRDATGRFP-----AGRPRPSPLDAGAASGAFYARYPL 432
TALPID3 pfam15324
Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for ...
 918-1121 7.47e-03

Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for Hedgehog signalling. Mutations in this gene noticed first in chickens lead to multiple abnormalities of development.


Pssm-ID: 434634 [Multi-domain]  Cd Length: 1288  Bit Score: 40.64  E-value: 7.47e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474   918 PTPKATPRETPSSTDTPLSRRSSVRGTSDTSPRRPQVSGSGAEEPRLPRSSGSISGRPGKDAPLQPRASFRKPSAKPLRN 997
Cdd:pfam15324  985 PTPVPTPQPTPPCSPPSPLKEPSPVKTPDSSPCVSEHDFFPVKEIPPEKGADTGPAVSLVITPTVTPIATPPPAATPTPP 1064

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474   998 IPRQKPEENKVSSPNSPDP----ESP--KEEPKAPQATGVSRALP------------PIPSFARNTVASSSRSLRTDAPP 1059
Cdd:pfam15324 1065 LSENSIDKLKSPSPELPKPwedsDLPleEENPNSEQEELHPRAVVmsvardeepesvVLPASPPEPKPLAPPPLGAAPPS 1144

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568922474  1060 AARTTGLTRTVSQRQLRVKGGSEDSASKDI--GTLKRASSARASKKCPESAGGSSANVETSLKG 1121
Cdd:pfam15324 1145 PPQSPSSSSSTLESSSSLTVTETETADRPIseGEILFSYGQMLAVRALEEGGLFLPNLNDSLSS 1208
 
Name Accession Description Interval E-value
FH2 pfam02181
Formin Homology 2 Domain;
94-458 7.41e-116

Formin Homology 2 Domain;


Pssm-ID: 396655  Cd Length: 372  Bit Score: 363.90  E-value: 7.41e-116
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474    94 KKKRMRSFFWKTIPEEQVRGktNIWTLAAKQQHQYQIDKKTIEELFGQQEDTSKASLPKRGGALNSSfrdaREEVTVLDA 173
Cdd:pfam02181    7 PKKKLKPLHWDKVRPSQDRG--TVWDKLDDESFELDGDLSELEELFSAKAKTKKNKKSEDKSSSKKK----PKEVSLLDP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474   174 KRSMNIGIFLKQFKKSPQSIVEDIYQGKSEHYGSETLREILKLLPESEEVKKLKAFNGDVSKLSLADSFLHCLIQVPNYS 253
Cdd:pfam02181   81 KRAQNIAILLRKLKLPPEEIIQAILEGDEDALDLELLENLLKMAPTKEELKKLKEYKGDPSELGRAEQFLLELSKIPRLE 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474   254 LRIEAMVLKKEFLPSCSSLFKDIRTLRAATKELMLCEELHSILHLVLQAGNIMNAGGYAGNAVGFKLSSLLKLADTKANK 333
Cdd:pfam02181  161 ARLRALLFKSTFEEEIEELKPSLEALEAASEELRNSRKFKKLLELILALGNYMNDGTRRGQAKGFKLSSLLKLSDTKSTD 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474   334 PGMNLLHFVAQEAQKQDAILLNFSEKLQHVQETSRLSLDITEAELHSLFVRTKSLQENIQL-------DQELCQQMEDFL 406
Cdd:pfam02181  241 NKTTLLHYLVKIIREKFPEVLDFSSELSHVKKAAKVNLEQLEKDVKQLERGLKKLERELELsaldehpDDKFREVLKEFL 320

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|..
gi 568922474   407 QFAVEKLAELELWKRELQGEAHTLIDFFCEDKETMKLDECFQIFRDFCTRFN 458
Cdd:pfam02181  321 KSAEEKLDKLESLLREALELFKELVEYFGEDPKETSPEEFFKILRDFLKEFK 372
FH2 smart00498
Formin Homology 2 Domain; FH proteins control rearrangements of the actin cytoskeleton, ...
 95-487 4.38e-60

Formin Homology 2 Domain; FH proteins control rearrangements of the actin cytoskeleton, especially in the context of cytokinesis and cell polarisation. Members of this family have been found to interact with Rho-GTPases, profilin and other actin-assoziated proteins. These interactions are mediated by the proline-rich FH1 domain, usually located in front of FH2 (but not listed in SMART). Despite this cytosolic function, vertebrate formins have been assigned functions within the nucleus. A set of Formin-Binding Proteins (FBPs) has been shown to bind FH1 with their WW domain.


Pssm-ID: 214697 [Multi-domain]  Cd Length: 392  Bit Score: 211.44  E-value: 4.38e-60
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474     95 KKRMRSFFWKTIPEEQVRGktniwTLAAKQQHQYQIDKKTIEELFGQQEDTSKASLPKRGGALNSSfRDAREEVTVLDAK 174
Cdd:smart00498    7 KKKLKPLHWDKLNPSDLSG-----TVWDKIDEESEGDLDELEELFSAKEKTKSASKDVSEKKSILK-KKASQEFKILDPK 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474    175 RSMNIGIFLKQFKKSPQSIVEDIYQGKSEHYGSETLREILKLLPESEEVKKLKAFNG-DVSKLSLADSFLHCLIQVPNYS 253
Cdd:smart00498   81 RSQNLAILLRKLHMSYEEIKEAILEGDEDVLSVDLLEQLLKYAPTKEELKKLREYKEeDPEELARAEQFLLLISNIPYLE 160

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474    254 LRIEAMVLKKEFLPSCSSLFKDIRTLRAATKELMLCEELHSILHLVLQAGNIMNAGGYAGNAVGFKLSSLLKLADTKANK 333
Cdd:smart00498  161 ERLNALLFKANFEEEVEDLKPQIEKVEAACEELRESKKFRKLLELILAIGNYMNGGSRRGQAYGFKLSSLLKLSDVKSAD 240

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474    334 PGMNLLHFVAQEaqkqdaillnfseklqhvqetsrlsldITEAELHSLfvrtkSLQENiqLDQELCQQMEDFLQFAVEKL 413
Cdd:smart00498  241 NKTTLLHFLVKI---------------------------IRKKYLGGL-----SDPEN--LDDKFIEVMKPFLKAAKEKY 286

                           330       340       350       360       370       380       390
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568922474    414 AELELWKRELQGEAHTLIDFFCEDKETMKLDECFQIFRDFCTRFNKAVKDNHDREEQERKQLQRQKEMEQKRYS 487
Cdd:smart00498  287 DKLQKDLSDLKTRFEKLVEYYGEDPKDTSPEEFFKDFNEFLKEFSKAAEENIKKEEEEEERRKKLVKETTEYEQ 360
PHA03247 PHA03247
large tegument protein UL36; Provisional
 823-1064 1.15e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 66.50  E-value: 1.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  823 PPGEVPAPKSSKSELSCQGGLPKDRPSRGKDAIAPKRnsfkeasvgASKPVSARRsQGVTTKPVRTLNSSENEHMRKVV- 901
Cdd:PHA03247 2624 PDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGR---------VSRPRRARR-LGRAAQASSPPQRPRRRAARPTVg 2693

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  902 PISKSSRGAGPWKRPEPTPKATPRETPSSTDTPLSRRSSVRGTSDTSPRRPqvsgsgAEEPRLPRSSGSISGRPGKDAPL 981
Cdd:PHA03247 2694 SLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAV------PAGPATPGGPARPARPPTTAGPP 2767

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  982 QPRASfRKPSAKPLRNIPRQKPEENKVSSPNSPDPESPKEEPKA--PQATGVSRALPPIPSFARNTVASSSRSLRTDAPP 1059
Cdd:PHA03247 2768 APAPP-AAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAvlAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPP 2846


                  ....*
gi 568922474 1060 AARTT 1064
Cdd:PHA03247 2847 PPSLP 2851
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 705-1142 3.34e-10

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 64.81  E-value: 3.34e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  705 GDRSSQPFAAGGDSLPPKDTDTQEVLSPageDDRTISDEPSSEALVSVVVTDTEDKDAGPLLYVSDTTDCSLTLDCSEGM 784
Cdd:PHA03307   18 GEFFPRPPATPGDAADDLLSGSQGQLVS---DSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLST 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  785 DSRAGGDkqEEEKEGDGSVSSGAGEAGSSQVSSNSVSSPPGEVPAPKSSKSELSCQGGLPKDRPSRGKDAIAPKRNSfKE 864
Cdd:PHA03307   95 LAPASPA--REGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASS-RQ 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  865 ASVGASKPVSARRSQGVTTKPVrtlnssenehmrkvvPISKSSRGAGPWKRPEPTPKATPRETPSSTDTPLSRRSSVRGT 944
Cdd:PHA03307  172 AALPLSSPEETARAPSSPPAEP---------------PPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASS 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  945 SDTSPRRPQVSGSGAEE--PRLPRSSGSISGRPGKDAPLQPRASfRKPSAKPlrniprqkpeenkVSSPNSPDPESPKEE 1022
Cdd:PHA03307  237 SDSSSSESSGCGWGPENecPLPRPAPITLPTRIWEASGWNGPSS-RPGPASS-------------SSSPRERSPSPSPSS 302

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474 1023 PKAPQATGVSRALppiPSFARNTVASSSRSLRTDAPPAARTTGLTRTVSqrqlRVKGGSEDSASKDIGTLKRASSARASK 1102
Cdd:PHA03307  303 PGSGPAPSSPRAS---SSSSSSRESSSSSTSSSSESSRGAAVSPGPSPS----RSPSPSRPPPPADPSSPRKRPRPSRAP 375

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 568922474 1103 KCPESAGGSSanveTSLKGRGTTERSSLRLKDSGQATLGR 1142
Cdd:PHA03307  376 SSPAASAGRP----TRRRARAAVAGRARRRDATGRFPAGR 411
PHA03247 PHA03247
large tegument protein UL36; Provisional
 524-1060 2.24e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.80  E-value: 2.24e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  524 PNSPSYRPPNTRRSRLSLGISADrelltfleSATSSPEDPNKfnslPRSSPRQArPTIAWMEPREQQSHGPNFTH----E 599
Cdd:PHA03247 2475 PGAPVYRRPAEARFPFAAGAAPD--------PGGGGPPDPDA----PPAPSRLA-PAILPDEPVGEPVHPRMLTWirglE 2541

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  600 PQASKIQEKAPPPAWQNQLPTTWREEPASPLPLAGRSRPSLRKRNSEPvGLGPTQSPPLLPLDlgvrehelvtgltqfDL 679
Cdd:PHA03247 2542 ELASDDAGDPPPPLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRP-DAPPQSARPRAPVD---------------DR 2605

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  680 QSPKSLEEGSQLTLNDFCPTklPSPGDRSSQPFAAGGDSLPPKDTDTQEVLSPAGEDDRtisdePSSEALVSVVVTDTED 759
Cdd:PHA03247 2606 GDPRGPAPPSPLPPDTHAPD--PPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVS-----RPRRARRLGRAAQASS 2678

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  760 KDAGPLLYVSDTTDCSLTldcsegmdSRAGGDKQEEEKEGDGSVSSGAGEAGSSQVSSNSVSSPPGEVPAPKSSKSELSC 839
Cdd:PHA03247 2679 PPQRPRRRAARPTVGSLT--------SLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPAT 2750

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  840 QG------------GLPKDRPSRGKDAIAPKR------NSFKEASVGASKPVSARRSQGVTTKPVRTLNSSENEhmRKVV 901
Cdd:PHA03247 2751 PGgparparppttaGPPAPAPPAAPAAGPPRRltrpavASLSESRESLPSPWDPADPPAAVLAPAAALPPAASP--AGPL 2828

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  902 PISKSSRGAGPWKRPEPTPKATPRETPSSTDTPLSRRSSVRG--TSDTSPRRPQVSGSGAeePRLPRSSGSISGRPGKDA 979
Cdd:PHA03247 2829 PPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSpaAKPAAPARPPVRRLAR--PAVSRSTESFALPPDQPE 2906

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  980 PL-QPRASFRKPSAKPLRNIPRQKPEENKVSSPNSPDPESPKEEPkAPQATG----------------VSRALPPIPSFA 1042
Cdd:PHA03247 2907 RPpQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAG-AGEPSGavpqpwlgalvpgrvaVPRFRVPQPAPS 2985

                         570
                  ....*....|....*...
gi 568922474 1043 RNTVASSSRSLRTDAPPA 1060
Cdd:PHA03247 2986 REAPASSTPPLTGHSLSR 3003
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 524-981 1.29e-07

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 56.33  E-value: 1.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  524 PNSPSYRPPNTRRSRLSLGISADRELLTFLESATSSPEDPNKFNSLPRSSPRQARPTIAWMEPREQQSHGPNFTHEPQAS 603
Cdd:PHA03307   25 PATPGDAADDLLSGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREG 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  604 KIQEKAPPPAwqnqLPTTWREEPASPLPLAGRSRPSLRKRnSEPVGLGPTQSPPLLPLDLG-VREHELVTGLTQFDLQSP 682
Cdd:PHA03307  105 SPTPPGPSSP----DPPPPTPPPASPPPSPAPDLSEMLRP-VGSPGPPPAASPPAAGASPAaVASDAASSRQAALPLSSP 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  683 KSLEEgsqltlndfCPTKLPSPGDRSSQPFAAGGDSLPPKDTDTQEVLSPAGEDDRTISDEPSSEALVSvVVTDTEDKDA 762
Cdd:PHA03307  180 EETAR---------APSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDS-SSSESSGCGW 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  763 GPLlyvsdttdcSLTLDCSEGMDSRAGGDKQEEEKEGDGSVSSGAGEAGssqvssnsvsSPPGEVPAPKSSKSelscqGG 842
Cdd:PHA03307  250 GPE---------NECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSS----------SPRERSPSPSPSSP-----GS 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  843 LPKDRPSRGKDAIAPKRnsfkEASVGASKPVSA-RRSQGVTTKPvrtlnssenEHMRKVVPISKSSRGAGPWKRPEPTPK 921
Cdd:PHA03307  306 GPAPSSPRASSSSSSSR----ESSSSSTSSSSEsSRGAAVSPGP---------SPSRSPSPSRPPPPADPSSPRKRPRPS 372

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568922474  922 ATPRETPSSTDTPLSRRSS-----VRGTSDTSPRRPqvsgsGAEEPRLPRSSGSISGRPGKDAPL 981
Cdd:PHA03307  373 RAPSSPAASAGRPTRRRARaavagRARRRDATGRFP-----AGRPRPSPLDAGAASGAFYARYPL 432
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 696-1060 2.81e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 51.71  E-value: 2.81e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  696 FCPTKLPSPGDRS-SQPFAAGGDSLPPKDTDTQEVLSPAGEDDRTISDEPSSEAlvSVVVTDTEDKDAGPllyvsdttDC 774
Cdd:PHA03307   65 FEPPTGPPPGPGTeAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPP--PTPPPASPPPSPAP--------DL 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  775 SLTLDCSEGMDSRaggDKQEEEKEGDGSVSSGAGEAGSSQVSSNSVSsPPGEVPAPKSSKSE--LSCQGGLPKDRPSRGK 852
Cdd:PHA03307  135 SEMLRPVGSPGPP---PAASPPAAGASPAAVASDAASSRQAALPLSS-PEETARAPSSPPAEppPSTPPAAASPRPPRRS 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  853 DAIAPKRNSFKEASVGASK-PVSARRSQGVTTKPVRTLNSSENEHMRKV---VPISKSSRGAGPWKRPEPTPkatPRETP 928
Cdd:PHA03307  211 SPISASASSPAPAPGRSAAdDAGASSSDSSSSESSGCGWGPENECPLPRpapITLPTRIWEASGWNGPSSRP---GPASS 287

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  929 SSTDTPLSRRSSvRGTSDTSPRRPQVSGSGAEEPrlPRSSGSISGRPGKDAPLQPRASFRKPSAKPLRNiprqkpeenkv 1008
Cdd:PHA03307  288 SSSPRERSPSPS-PSSPGSGPAPSSPRASSSSSS--SRESSSSSTSSSSESSRGAAVSPGPSPSRSPSP----------- 353

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 568922474 1009 SSPNSP-DPESPKEEPKAPQATGVSRALPPIPSFARNTVASSSRSLRTDAPPA 1060
Cdd:PHA03307  354 SRPPPPaDPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGR 406
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 846-1026 7.38e-06

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 50.46  E-value: 7.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  846 DRPSRGKDA--IAPKRNSFKEASVGASKPVSARRSQGVTTKPVRTlnsSENEHMRKVVPIS--KSSRGAGPWKRPE-PTP 920
Cdd:PTZ00449  508 DEPPEGPEAsgLPPKAPGDKEGEEGEHEDSKESDEPKEGGKPGET---KEGEVGKKPGPAKehKPSKIPTLSKKPEfPKD 584

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  921 KATPREtPSSTDTPLSRRSSVRGTSDTSPRRPQVSgsgaeepRLPRSSgsisgrpgkDAPLQPRASFRKPSakPLRNIPR 1000
Cdd:PTZ00449  585 PKHPKD-PEEPKKPKRPRSAQRPTRPKSPKLPELL-------DIPKSP---------KRPESPKSPKRPPP--PQRPSSP 645

                         170       180
                  ....*....|....*....|....*.
gi 568922474 1001 QKPEenkvsSPNSPDPESPKEEPKAP 1026
Cdd:PTZ00449  646 ERPE-----GPKIIKSPKPPKSPKPP 666
PHA03247 PHA03247
large tegument protein UL36; Provisional
 866-1108 1.90e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.17  E-value: 1.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  866 SVGASKPVSARRSQGVTTKPVRTlnSSENEHMRKVVPISKSSRGAGPWKRPEPTPKATPRETPSSTDTPLSRRSSVRGTS 945
Cdd:PHA03247 2567 SVPPPRPAPRPSEPAVTSRARRP--DAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPP 2644

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  946 DTSPRRPQVSGSGAEEPRLPRSSGSISGRPGKDAPLQ-PRASFRKPSAKPLRNIPRQKPEEN------KVSSPNSPDPES 1018
Cdd:PHA03247 2645 TVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQrPRRRAARPTVGSLTSLADPPPPPPtpepapHALVSATPLPPG 2724

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474 1019 PKEEPKAPQATGVSRALPPIPS--FARNTVASSSRSLRTDAPPAARTTGLTRTVSQRQLRVKGGSEDSASKDIGTLKRAS 1096
Cdd:PHA03247 2725 PAAARQASPALPAAPAPPAVPAgpATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDP 2804

                         250
                  ....*....|..
gi 568922474 1097 SARASKKCPESA 1108
Cdd:PHA03247 2805 ADPPAAVLAPAA 2816
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 781-1036 5.55e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 47.38  E-value: 5.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  781 SEGMDSRAGGDKQEEEKEGDGSVSSGAGEAGSSQVSSNSVSSP--------PGEVPAPKSSKSELSCQGGLPKDRPSRGK 852
Cdd:PTZ00449  537 SKESDEPKEGGKPGETKEGEVGKKPGPAKEHKPSKIPTLSKKPefpkdpkhPKDPEEPKKPKRPRSAQRPTRPKSPKLPE 616

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  853 DAIAPKRNSFKEAS------VGASKPVSARRSQGvtTKPVRTLNSSE---------------NEHMRKVVPISKSSRGAG 911
Cdd:PTZ00449  617 LLDIPKSPKRPESPkspkrpPPPQRPSSPERPEG--PKIIKSPKPPKspkppfdpkfkekfyDDYLDAAAKSKETKTTVV 694

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  912 PWKRPEPTPKATPRETPSSTDTPLSRRSSVRGTSDTSPRRPqvsgsgAEEPRLPRSSGSISGRPgkdaPLQPRASFRK-P 990
Cdd:PTZ00449  695 LDESFESILKETLPETPGTPFTTPRPLPPKLPRDEEFPFEP------IGDPDAEQPDDIEFFTP----PEEERTFFHEtP 764

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 568922474  991 SAKPLRNIPRQKPEENKVSSpNSPDPESPKEEPKAP-----QATGVSRALP 1036
Cdd:PTZ00449  765 ADTPLPDILAEEFKEEDIHA-ETGEPDEAMKRPDSPsehedKPPGDHPSLP 814
PHA03247 PHA03247
large tegument protein UL36; Provisional
 517-1052 5.88e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.63  E-value: 5.88e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  517 PSFLKPRPNSPSYR--------PPNTRRSRLSLGISAD--RELLTFLESATSSPEDPNKFNSLPR-SSPRQARPTIAWME 585
Cdd:PHA03247 2570 PPRPAPRPSEPAVTsrarrpdaPPQSARPRAPVDDRGDprGPAPPSPLPPDTHAPDPPPPSPSPAaNEPDPHPPPTVPPP 2649

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  586 PREQQSHGPNFTHEPQASKIQEKAPPPAWQNQLPTTwREEPASPLPLAGRSRPSLRKRNSEPvglGPTQSPPLLPLDLGV 665
Cdd:PHA03247 2650 ERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRR-RAARPTVGSLTSLADPPPPPPTPEP---APHALVSATPLPPGP 2725

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  666 REHELVTGLTQFDLQSPKSlEEGSQLTLNDFCPTKLPSPGDRSSQPFAAGGDSLPPKDTDTQEV--LSPAGEDDRTISDe 743
Cdd:PHA03247 2726 AAARQASPALPAAPAPPAV-PAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVasLSESRESLPSPWD- 2803

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  744 PSSEALVSVVVTDTEDKDAGPLLYVSDTTDCSLTldcsegMDSRAGGDKQEEEKEGdGSVSSGA-----GEAGSSQVSSN 818
Cdd:PHA03247 2804 PADPPAAVLAPAAALPPAASPAGPLPPPTSAQPT------APPPPPGPPPPSLPLG-GSVAPGGdvrrrPPSRSPAAKPA 2876

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  819 SVSSPPGE-VPAPKSSKSELSCqgGLPKDRPSRGKDAIAPKRNSFKEASVGASKPVSARRSQGVTTKPV----RTLNSSE 893
Cdd:PHA03247 2877 APARPPVRrLARPAVSRSTESF--ALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLapttDPAGAGE 2954

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  894 NEHMRKVVPISKSSRGAGPWKRPEPTPKATPRETPSSTDTPLSRRSSVRGTSDTSprrpqvSGSGAEEPRLPRSSGSISG 973
Cdd:PHA03247 2955 PSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWAS------SLALHEETDPPPVSLKQTL 3028

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  974 RPGKDAPLQPRASFRKPSAKPLrNIPRQKPEENKVSSPNSPDPESPKEEPKAPQATGVSRALPPIPSFA---RNTVASSS 1050
Cdd:PHA03247 3029 WPPDDTEDSDADSLFDSDSERS-DLEALDPLPPEPHDPFAHEPDPATPEAGARESPSSQFGPPPLSANAalsRRYVRSTG 3107


                  ..
gi 568922474 1051 RS 1052
Cdd:PHA03247 3108 RS 3109
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 905-1040 7.16e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 46.99  E-value: 7.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  905 KSSRGAGPWKRPEPTPKATPRETPSSTDTPLSRRSSvrgtsdTSPRRPqvsgsgaEEPRLPRSsgsisgrpgkdaPLQPR 984
Cdd:PTZ00449  550 GETKEGEVGKKPGPAKEHKPSKIPTLSKKPEFPKDP------KHPKDP-------EEPKKPKR------------PRSAQ 604

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 568922474  985 ASFRKPSAK--PLRNIPRQKPEENKVSSPNSPDPESPKEEPKAPQATGVSRALPPIPS 1040
Cdd:PTZ00449  605 RPTRPKSPKlpELLDIPKSPKRPESPKSPKRPPPPQRPSSPERPEGPKIIKSPKPPKS 662
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 791-1038 8.63e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 46.99  E-value: 8.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  791 DKQEEEKEGDGSvSSGAGEAGSSQVSSNSVSSPPGEVPAPKSSKSELSCQGGLPKDRPSRGKDAIAPKRNSFKEASVGAS 870
Cdd:PTZ00449  505 DKHDEPPEGPEA-SGLPPKAPGDKEGEEGEHEDSKESDEPKEGGKPGETKEGEVGKKPGPAKEHKPSKIPTLSKKPEFPK 583

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  871 KPVSARRSQGvTTKPVRTLNSSEnehmrkvvPISKSSRgagpwKRPEPT--PKatpreTPSSTDTPLSRRSSVRGTSDTS 948
Cdd:PTZ00449  584 DPKHPKDPEE-PKKPKRPRSAQR--------PTRPKSP-----KLPELLdiPK-----SPKRPESPKSPKRPPPPQRPSS 644

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  949 PRRPqvsgsgaEEPRLPRSSGS-ISGRPGKDAPLQPR----------------------ASFRKPSAKPLRNIPRQKPEE 1005
Cdd:PTZ00449  645 PERP-------EGPKIIKSPKPpKSPKPPFDPKFKEKfyddyldaaaksketkttvvldESFESILKETLPETPGTPFTT 717

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 568922474 1006 NKVSSPNSP-DPESPKE---EPKAPQATGVSRALPPI 1038
Cdd:PTZ00449  718 PRPLPPKLPrDEEFPFEpigDPDAEQPDDIEFFTPPE 754
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
828-1061 6.17e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 44.07  E-value: 6.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  828 PAPKSSkselSCQGGLPKDRPSRGKDAIAPKRNSFKEASVG-ASKPVSARRSQGVTTKPVrtlnssenehmrkvVPISkS 906
Cdd:PRK07003  360 PAVTGG----GAPGGGVPARVAGAVPAPGARAAAAVGASAVpAVTAVTGAAGAALAPKAA--------------AAAA-A 420

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  907 SRGAGPWKRPEPTPKATPRETPSSTDTPLSRRSSVRGTSDTSPrrpqvsgsgAEEPRLPRSSGSISGRPGKDAP------ 980
Cdd:PRK07003  421 TRAEAPPAAPAPPATADRGDDAADGDAPVPAKANARASADSRC---------DERDAQPPADSGSASAPASDAPpdaafe 491

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  981 LQPRASFRKPSAKPLRNIPRQK---PEENKVSSPNSPDPESPKEEPKAP----QATGVSRALPPIpsfaRNT--VASSSR 1051
Cdd:PRK07003  492 PAPRAAAPSAATPAAVPDARAPaaaSREDAPAAAAPPAPEARPPTPAAAapaaRAGGAAAALDVL----RNAgmRVSSDR 567

                         250
                  ....*....|
gi 568922474 1052 SLRTDAPPAA 1061
Cdd:PRK07003  568 GARAAAAAKP 577
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
909-1081 4.54e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 41.37  E-value: 4.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  909 GAGPWKRPEPTPKATPRETPSSTDTPLSRRSSVRGTSDTSPRRPQVSGSGAEEPRLP-------RSSGSISGRPGKDAPL 981
Cdd:PRK07003  370 GGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPpaapappATADRGDDAADGDAPV 449

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  982 QPRASFRKP---SAKPLRNIPRQKPEEnkVSSPNSPDPESPKEEPKAPQATGVSRALPPIPSFARNTVASSSRSLRTDAP 1058
Cdd:PRK07003  450 PAKANARASadsRCDERDAQPPADSGS--ASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAAAAP 527

                         170       180
                  ....*....|....*....|...
gi 568922474 1059 PAARTTGLTRTVSQRQLRVKGGS 1081
Cdd:PRK07003  528 PAPEARPPTPAAAAPAARAGGAA 550
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
805-1062 5.56e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 40.99  E-value: 5.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  805 SGAGEAGSSQVSSNSVSSPPGEVPAPKSSKSELSCQGGLPKDRPSRGKDAIAPKRNSFKEASVGASKPVSARrsqgvttk 884
Cdd:PRK07003  387 AAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGDAPVPAKANARAS-------- 458

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  885 pvrtlnSSENEHMRKVVPISKSSRGAGPWKRPEPTPKATPrETPSSTDTPLSRRSSVRGTSDTSPRRPQVSGSGAEEPRL 964
Cdd:PRK07003  459 ------ADSRCDERDAQPPADSGSASAPASDAPPDAAFEP-APRAAAPSAATPAAVPDARAPAAASREDAPAAAAPPAPE 531

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474  965 PRSSGSISGRPGKdaplqpRASFRKPSAKPLRNIPRqkpeenKVSS---PNSPDPESPKEEPKAPQATGVSRALPPIPsf 1041
Cdd:PRK07003  532 ARPPTPAAAAPAA------RAGGAAAALDVLRNAGM------RVSSdrgARAAAAAKPAAAPAAAPKPAAPRVAVQVP-- 597

                         250       260
                  ....*....|....*....|.
gi 568922474 1042 arnTVASSSRSLRTDAPPAAR 1062
Cdd:PRK07003  598 ---TPRARAATGDAPPNGAAR 615
TALPID3 pfam15324
Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for ...
 918-1121 7.47e-03

Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for Hedgehog signalling. Mutations in this gene noticed first in chickens lead to multiple abnormalities of development.


Pssm-ID: 434634 [Multi-domain]  Cd Length: 1288  Bit Score: 40.64  E-value: 7.47e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474   918 PTPKATPRETPSSTDTPLSRRSSVRGTSDTSPRRPQVSGSGAEEPRLPRSSGSISGRPGKDAPLQPRASFRKPSAKPLRN 997
Cdd:pfam15324  985 PTPVPTPQPTPPCSPPSPLKEPSPVKTPDSSPCVSEHDFFPVKEIPPEKGADTGPAVSLVITPTVTPIATPPPAATPTPP 1064

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568922474   998 IPRQKPEENKVSSPNSPDP----ESP--KEEPKAPQATGVSRALP------------PIPSFARNTVASSSRSLRTDAPP 1059
Cdd:pfam15324 1065 LSENSIDKLKSPSPELPKPwedsDLPleEENPNSEQEELHPRAVVmsvardeepesvVLPASPPEPKPLAPPPLGAAPPS 1144

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568922474  1060 AARTTGLTRTVSQRQLRVKGGSEDSASKDI--GTLKRASSARASKKCPESAGGSSANVETSLKG 1121
Cdd:pfam15324 1145 PPQSPSSSSSTLESSSSLTVTETETADRPIseGEILFSYGQMLAVRALEEGGLFLPNLNDSLSS 1208
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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