NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|568964222|ref|XP_006512366|]
View 

ATP-dependent RNA helicase DHX30 isoform X2 [Mus musculus]

Protein Classification

ATP-dependent RNA helicase( domain architecture ID 13388279)

DEAD/DEAH box containing ATP-dependent RNA helicase catalyzes the unwinding of RNA, similar to DEAH box protein 34 (DHX34) that is required for nonsense-mediated decay (NMD) degradation of mRNA transcripts containing premature stop codons

CATH:  3.40.50.300
EC:  3.6.4.13
Gene Ontology:  GO:0005524|GO:0003724|GO:0003676|GO:0016887|GO:0003723
PubMed:  34680866|19747077|22922795|20206133|21779027|20225155

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
HrpA super family cl34328
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
426-958 4.11e-135

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG1643:

Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 432.20  E-value: 4.11e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  426 PIWQEAPQLPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLEryvtEGRGARCNVIITQPRRISAVSVAQRVSH 505
Cdd:COG1643     2 SLITYPPDLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLE----LGWGAGGRIGMLEPRRLAARAAAERMAE 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  506 ELGPSLRRNVGFQVRLESK--PPARggaLLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQ-RLN 582
Cdd:COG1643    78 ELGEPVGETVGYRVRFEDKvsAATR---IEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQpALR 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  583 PALRLVLMSATGDNERFSRYFGGCPVIKVPGFMYPVKEHYLEDilaklgkhqyphrhrhheSEDECALdLDLVTDLVLHI 662
Cdd:COG1643   155 PDLKLLVMSATLDAERFARLLGDAPVIESSGRTYPVEVRYRPL------------------PADERDL-EDAVADAVREA 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  663 dARGEPGGILCFLPGWQEIKGVQQRLQEALGMHeskYLILPVHSNIPMMDQKAIFQQPPLGVRKIVLATNIAETSITVND 742
Cdd:COG1643   216 -LAEEPGDILVFLPGEREIRRTAEALRGRLPPD---TEILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPG 291

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  743 IVHVVDSGLHKEERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRLEKMVPFQVPEILRTPLENLVLQ 822
Cdd:COG1643   292 IRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEDFARRPAFTDPEILRADLASLILE 371

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  823 -AKIHMPEKTAVEFLskavDSPNIKAVDEAVILLQEIGVLDQREYLTTLGQRLAHISTDPRLAKAIVLAAIFRCLHPLLV 901
Cdd:COG1643   372 lAAWGLGDPEDLPFL----DPPPARAIADARALLQELGALDADGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAI 447

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568964222  902 VVSCLT-RDPfssslqnraevdkvkalLSHDSGSDHLAFVRAVAGWEEVL----------RWQDRTSR 958
Cdd:COG1643   448 LAALLSeRDP-----------------RRGAAGSDLLARLNLWRRLREQQreflsylrlrEWRDLARQ 498
OB_NTP_bind pfam07717
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ...
 1015-1102 5.19e-07

Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.


:

Pssm-ID: 400182 [Multi-domain]  Cd Length: 82  Bit Score: 48.40  E-value: 5.19e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  1015 VKGVLMAGLYPNLiqvrqGKVTRQGKfkpnsvTYRTKSGN--ILLHKSTINREATRLRSRWLTYFMAVKSNgSVFVRDSS 1092
Cdd:pfam07717    1 LRAALAAGLYPNV-----ARRDPKGK------GYTTLSDNqrVFIHPSSVLFNEKTFPPEWVVYQELVETT-KVYIRTVT 68

                           90
                   ....*....|
gi 568964222  1093 QVHPLAVLLL 1102
Cdd:pfam07717   69 AISPEWLLLF 78
 
Name Accession Description Interval E-value
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
426-958 4.11e-135

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 432.20  E-value: 4.11e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  426 PIWQEAPQLPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLEryvtEGRGARCNVIITQPRRISAVSVAQRVSH 505
Cdd:COG1643     2 SLITYPPDLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLE----LGWGAGGRIGMLEPRRLAARAAAERMAE 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  506 ELGPSLRRNVGFQVRLESK--PPARggaLLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQ-RLN 582
Cdd:COG1643    78 ELGEPVGETVGYRVRFEDKvsAATR---IEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQpALR 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  583 PALRLVLMSATGDNERFSRYFGGCPVIKVPGFMYPVKEHYLEDilaklgkhqyphrhrhheSEDECALdLDLVTDLVLHI 662
Cdd:COG1643   155 PDLKLLVMSATLDAERFARLLGDAPVIESSGRTYPVEVRYRPL------------------PADERDL-EDAVADAVREA 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  663 dARGEPGGILCFLPGWQEIKGVQQRLQEALGMHeskYLILPVHSNIPMMDQKAIFQQPPLGVRKIVLATNIAETSITVND 742
Cdd:COG1643   216 -LAEEPGDILVFLPGEREIRRTAEALRGRLPPD---TEILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPG 291

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  743 IVHVVDSGLHKEERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRLEKMVPFQVPEILRTPLENLVLQ 822
Cdd:COG1643   292 IRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEDFARRPAFTDPEILRADLASLILE 371

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  823 -AKIHMPEKTAVEFLskavDSPNIKAVDEAVILLQEIGVLDQREYLTTLGQRLAHISTDPRLAKAIVLAAIFRCLHPLLV 901
Cdd:COG1643   372 lAAWGLGDPEDLPFL----DPPPARAIADARALLQELGALDADGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAI 447

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568964222  902 VVSCLT-RDPfssslqnraevdkvkalLSHDSGSDHLAFVRAVAGWEEVL----------RWQDRTSR 958
Cdd:COG1643   448 LAALLSeRDP-----------------RRGAAGSDLLARLNLWRRLREQQreflsylrlrEWRDLARQ 498
DEXHc_DHX30 cd17976
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ...
 434-611 5.19e-121

DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350734 [Multi-domain]  Cd Length: 178  Bit Score: 370.66  E-value: 5.19e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  434 LPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRR 513
Cdd:cd17976     1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILEDYVLRGRGARCNVVITQPRRISAVSVAQRVAHELGPNLRR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  514 NVGFQVRLESKPPARGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSAT 593
Cdd:cd17976    81 NVGYQVRLESRPPPRGGALLFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQLNPELRVVLMSAT 160

                         170
                  ....*....|....*...
gi 568964222  594 GDNERFSRYFGGCPVIKV 611
Cdd:cd17976   161 GDNQRLSRYFGGCPVVRV 178
PRK11131 PRK11131
ATP-dependent RNA helicase HrpA; Provisional
 408-940 2.59e-83

ATP-dependent RNA helicase HrpA; Provisional


Pssm-ID: 182986 [Multi-domain]  Cd Length: 1294  Bit Score: 297.74  E-value: 2.59e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  408 AEEVRLSQSLLELWRRRGPIWQEAPQLPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLERyvteGRGARCNVI 487
Cdd:PRK11131   47 AKEIAQAAQRVLLREAARPEITYPENLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLEL----GRGVKGLIG 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  488 ITQPRRISAVSVAQRVSHELGPSLRRNVGFQVRLESKPPARGGALLFcTVGILLRKLQSNPSLEGVSHVIVDEVHERDVN 567
Cdd:PRK11131  123 HTQPRRLAARTVANRIAEELETELGGCVGYKVRFNDQVSDNTMVKLM-TDGILLAEIQQDRLLMQYDTIIIDEAHERSLN 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  568 TDFLLILLKGLQRLNPALRLVLMSATGDNERFSRYFGGCPVIKVPGFMYPVKEHYledilaklgkhqyphRHRHHESEDE 647
Cdd:PRK11131  202 IDFILGYLKELLPRRPDLKVIITSATIDPERFSRHFNNAPIIEVSGRTYPVEVRY---------------RPIVEEADDT 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  648 CALDLDLVTDLVLHIDARGePGGILCFLPGWQEIKGVQQRLQEALGMHESkylILPVHSNIPMMDQKAIFQqpPLGVRKI 727
Cdd:PRK11131  267 ERDQLQAIFDAVDELGREG-PGDILIFMSGEREIRDTADALNKLNLRHTE---ILPLYARLSNSEQNRVFQ--SHSGRRI 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  728 VLATNIAETSITVNDIVHVVDSGLHKEERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRLEKMVPFQ 807
Cdd:PRK11131  341 VLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDDFLSRPEFT 420

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  808 VPEILRTPLENLVLQ-AKIHMPEKTAVEFlskaVDSPNIKAVDEAVILLQEIGVLDQRE-----YLTTLGQRLAHISTDP 881
Cdd:PRK11131  421 DPEILRTNLASVILQmTALGLGDIAAFPF----VEAPDKRNIQDGVRLLEELGAITTDEqasayKLTPLGRQLAQLPVDP 496

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  882 RLAKAIVLAAIFRCLHPLLVVVSCLT-RDPFSSSLQNRAEVDKvKALLSHDSGSDHLAFV 940
Cdd:PRK11131  497 RLARMVLEAQKHGCVREVMIITSALSiQDPRERPMDKQQASDE-KHRRFADKESDFLAFV 555
DEXDc smart00487
DEAD-like helicases superfamily;
438-617 2.03e-24

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 102.18  E-value: 2.03e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222    438 PHRDTILSAIEQHP-VVVISGDTGCGKTTRIPQLLLERYvteGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRRNVG 516
Cdd:smart00487   11 PYQKEAIEALLSGLrDVILAAPTGSGKTLAALLPALEAL---KRGKGGRVLVLVPTRELAEQWAEELKKLGPSLGLKVVG 87

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222    517 FQVRLESKPPAR-----GGALLFCTVGILLRKLQSNP-SLEGVSHVIVDEVHERDvNTDFLLILLKGLQRLNPALRLVLM 590
Cdd:smart00487   88 LYGGDSKREQLRklesgKTDILVTTPGRLLDLLENDKlSLSNVDLVILDEAHRLL-DGGFGDQLEKLLKLLPKNVQLLLL 166

                           170       180
                    ....*....|....*....|....*....
gi 568964222    591 SAT--GDNERFSRYFGGCPVIKVPGFMYP 617
Cdd:smart00487  167 SATppEEIENLLELFLNDPVFIDVGFTPL 195
HA2 pfam04408
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ...
 851-939 4.00e-17

Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 461295 [Multi-domain]  Cd Length: 104  Bit Score: 78.05  E-value: 4.00e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222   851 AVILLQEIGVLDQREYLTTLGQRLAHISTDPRLAKAIVLAAIFRCLHPLLVVVSCLT-RDPFSSSLQ------------- 916
Cdd:pfam04408    1 ALELLYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSvRDPFVQPNFldprsaakaarrr 80

                           90       100
                   ....*....|....*....|....
gi 568964222   917 NRAEVDKVKALLSH-DSGSDHLAF 939
Cdd:pfam04408   81 RRAADEKARAKFARlDLEGDHLTL 104
OB_NTP_bind pfam07717
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ...
 1015-1102 5.19e-07

Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.


Pssm-ID: 400182 [Multi-domain]  Cd Length: 82  Bit Score: 48.40  E-value: 5.19e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  1015 VKGVLMAGLYPNLiqvrqGKVTRQGKfkpnsvTYRTKSGN--ILLHKSTINREATRLRSRWLTYFMAVKSNgSVFVRDSS 1092
Cdd:pfam07717    1 LRAALAAGLYPNV-----ARRDPKGK------GYTTLSDNqrVFIHPSSVLFNEKTFPPEWVVYQELVETT-KVYIRTVT 68

                           90
                   ....*....|
gi 568964222  1093 QVHPLAVLLL 1102
Cdd:pfam07717   69 AISPEWLLLF 78
 
Name Accession Description Interval E-value
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
426-958 4.11e-135

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 432.20  E-value: 4.11e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  426 PIWQEAPQLPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLEryvtEGRGARCNVIITQPRRISAVSVAQRVSH 505
Cdd:COG1643     2 SLITYPPDLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLE----LGWGAGGRIGMLEPRRLAARAAAERMAE 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  506 ELGPSLRRNVGFQVRLESK--PPARggaLLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQ-RLN 582
Cdd:COG1643    78 ELGEPVGETVGYRVRFEDKvsAATR---IEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQpALR 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  583 PALRLVLMSATGDNERFSRYFGGCPVIKVPGFMYPVKEHYLEDilaklgkhqyphrhrhheSEDECALdLDLVTDLVLHI 662
Cdd:COG1643   155 PDLKLLVMSATLDAERFARLLGDAPVIESSGRTYPVEVRYRPL------------------PADERDL-EDAVADAVREA 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  663 dARGEPGGILCFLPGWQEIKGVQQRLQEALGMHeskYLILPVHSNIPMMDQKAIFQQPPLGVRKIVLATNIAETSITVND 742
Cdd:COG1643   216 -LAEEPGDILVFLPGEREIRRTAEALRGRLPPD---TEILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPG 291

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  743 IVHVVDSGLHKEERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRLEKMVPFQVPEILRTPLENLVLQ 822
Cdd:COG1643   292 IRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEDFARRPAFTDPEILRADLASLILE 371

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  823 -AKIHMPEKTAVEFLskavDSPNIKAVDEAVILLQEIGVLDQREYLTTLGQRLAHISTDPRLAKAIVLAAIFRCLHPLLV 901
Cdd:COG1643   372 lAAWGLGDPEDLPFL----DPPPARAIADARALLQELGALDADGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAI 447

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568964222  902 VVSCLT-RDPfssslqnraevdkvkalLSHDSGSDHLAFVRAVAGWEEVL----------RWQDRTSR 958
Cdd:COG1643   448 LAALLSeRDP-----------------RRGAAGSDLLARLNLWRRLREQQreflsylrlrEWRDLARQ 498
DEXHc_DHX30 cd17976
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ...
 434-611 5.19e-121

DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350734 [Multi-domain]  Cd Length: 178  Bit Score: 370.66  E-value: 5.19e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  434 LPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRR 513
Cdd:cd17976     1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILEDYVLRGRGARCNVVITQPRRISAVSVAQRVAHELGPNLRR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  514 NVGFQVRLESKPPARGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSAT 593
Cdd:cd17976    81 NVGYQVRLESRPPPRGGALLFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQLNPELRVVLMSAT 160

                         170
                  ....*....|....*...
gi 568964222  594 GDNERFSRYFGGCPVIKV 611
Cdd:cd17976   161 GDNQRLSRYFGGCPVVRV 178
PRK11131 PRK11131
ATP-dependent RNA helicase HrpA; Provisional
 408-940 2.59e-83

ATP-dependent RNA helicase HrpA; Provisional


Pssm-ID: 182986 [Multi-domain]  Cd Length: 1294  Bit Score: 297.74  E-value: 2.59e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  408 AEEVRLSQSLLELWRRRGPIWQEAPQLPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLERyvteGRGARCNVI 487
Cdd:PRK11131   47 AKEIAQAAQRVLLREAARPEITYPENLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLEL----GRGVKGLIG 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  488 ITQPRRISAVSVAQRVSHELGPSLRRNVGFQVRLESKPPARGGALLFcTVGILLRKLQSNPSLEGVSHVIVDEVHERDVN 567
Cdd:PRK11131  123 HTQPRRLAARTVANRIAEELETELGGCVGYKVRFNDQVSDNTMVKLM-TDGILLAEIQQDRLLMQYDTIIIDEAHERSLN 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  568 TDFLLILLKGLQRLNPALRLVLMSATGDNERFSRYFGGCPVIKVPGFMYPVKEHYledilaklgkhqyphRHRHHESEDE 647
Cdd:PRK11131  202 IDFILGYLKELLPRRPDLKVIITSATIDPERFSRHFNNAPIIEVSGRTYPVEVRY---------------RPIVEEADDT 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  648 CALDLDLVTDLVLHIDARGePGGILCFLPGWQEIKGVQQRLQEALGMHESkylILPVHSNIPMMDQKAIFQqpPLGVRKI 727
Cdd:PRK11131  267 ERDQLQAIFDAVDELGREG-PGDILIFMSGEREIRDTADALNKLNLRHTE---ILPLYARLSNSEQNRVFQ--SHSGRRI 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  728 VLATNIAETSITVNDIVHVVDSGLHKEERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRLEKMVPFQ 807
Cdd:PRK11131  341 VLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDDFLSRPEFT 420

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  808 VPEILRTPLENLVLQ-AKIHMPEKTAVEFlskaVDSPNIKAVDEAVILLQEIGVLDQRE-----YLTTLGQRLAHISTDP 881
Cdd:PRK11131  421 DPEILRTNLASVILQmTALGLGDIAAFPF----VEAPDKRNIQDGVRLLEELGAITTDEqasayKLTPLGRQLAQLPVDP 496

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  882 RLAKAIVLAAIFRCLHPLLVVVSCLT-RDPFSSSLQNRAEVDKvKALLSHDSGSDHLAFV 940
Cdd:PRK11131  497 RLARMVLEAQKHGCVREVMIITSALSiQDPRERPMDKQQASDE-KHRRFADKESDFLAFV 555
DEXHc_RHA-like cd17917
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ...
 450-611 3.59e-81

DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438707 [Multi-domain]  Cd Length: 159  Bit Score: 262.01  E-value: 3.59e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  450 HPVVVISGDTGCGKTTRIPQLLLERYVTegRGARCNVIITQPRRISAVSVAQRVSHELGPSLRRNVGFQVRLESKPPaRG 529
Cdd:cd17917     1 NQVVVIVGETGSGKTTQVPQFLLEDGLA--KGGKGRIVCTQPRRIAAISVAERVAEERGEKLGEEVGYQIRFESKTS-SK 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  530 GALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSATGDNERFSRYFGGCPVI 609
Cdd:cd17917    78 TRIKFCTDGILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKDLLRKRPDLKVILMSATLDAEKFSSYFGGAPVI 157


                  ..
gi 568964222  610 KV 611
Cdd:cd17917   158 HI 159
PRK11664 PRK11664
ATP-dependent RNA helicase HrpB; Provisional
 432-891 7.22e-81

ATP-dependent RNA helicase HrpB; Provisional


Pssm-ID: 236950 [Multi-domain]  Cd Length: 812  Bit Score: 282.97  E-value: 7.22e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  432 PQLPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRgarcnVIITQPRRISAVSVAQRVSHELGPSL 511
Cdd:PRK11664    2 SSLPVAAVLPELLTALKTAPQVLLKAPTGAGKSTWLPLQLLQHGGINGK-----IIMLEPRRLAARNVAQRLAEQLGEKP 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  512 RRNVGFQVRLESK--PPARggaLLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQR-LNPALRLV 588
Cdd:PRK11664   77 GETVGYRMRAESKvgPNTR---LEVVTEGILTRMIQRDPELSGVGLVILDEFHERSLQADLALALLLDVQQgLRDDLKLL 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  589 LMSATGDNERFSRYFGGCPVIKVPGFMYPVKEHYledilAKLGKHQYphrhrhheSEDECAldlDLVTDLVlhidaRGEP 668
Cdd:PRK11664  154 IMSATLDNDRLQQLLPDAPVIVSEGRSFPVERRY-----QPLPAHQR--------FDEAVA---RATAELL-----RQES 212

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  669 GGILCFLPGWQEIKGVQQRLQEALGmheSKYLILPVHSNIPMMDQ-KAIfQQPPLGVRKIVLATNIAETSITVNDIVHVV 747
Cdd:PRK11664  213 GSLLLFLPGVGEIQRVQEQLASRVA---SDVLLCPLYGALSLAEQqKAI-LPAPAGRRKVVLATNIAETSLTIEGIRLVV 288

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  748 DSGLHKEERYDLKTKVSCLETVWVSRANVIQRRGRAGRCQSGFAYHLFPRSRLEKMVPFQVPEILRTPLENLV---LQAK 824
Cdd:PRK11664  289 DSGLERVARFDPKTGLTRLVTQRISQASMTQRAGRAGRLEPGICLHLYSKEQAERAAAQSEPEILHSDLSGLLlelLQWG 368

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568964222  825 IHMPEKTaveflsKAVDSPNIKAVDEAVILLQEIGVLDQREYLTTLGQRLAHISTDPRLAkAIVLAA 891
Cdd:PRK11664  369 CHDPAQL------SWLDQPPAAALAAAKRLLQQLGALDGQGRLTARGRKMAALGNDPRLA-AMLVAA 428
SF2_C_RHA cd18791
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ...
 616-795 3.20e-78

C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350178 [Multi-domain]  Cd Length: 171  Bit Score: 254.38  E-value: 3.20e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  616 YPVKEHYLEDILAKLGKHqyphrhrhheSEDECALDLDLVTDLVLHIDARGEPGGILCFLPGWQEIKGVQQRL-QEALGM 694
Cdd:cd18791     1 FPVEVYYLEDILELLGIS----------SEKEDPDYVDAAVRLILQIHRTEEPGDILVFLPGQEEIERLCELLrEELLSP 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  695 HESKYLILPVHSNIPMMDQKAIFQQPPLGVRKIVLATNIAETSITVNDIVHVVDSGLHKEERYDLKTKVSCLETVWVSRA 774
Cdd:cd18791    71 DLGKLLVLPLHSSLPPEEQQRVFEPPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKA 150

                         170       180
                  ....*....|....*....|.
gi 568964222  775 NVIQRRGRAGRCQSGFAYHLF 795
Cdd:cd18791   151 SAEQRAGRAGRTRPGKCYRLY 171
DEXHc_DHX9 cd17972
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ...
 404-611 1.43e-72

DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350730 [Multi-domain]  Cd Length: 234  Bit Score: 241.28  E-value: 1.43e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  404 PLSEAEEVRLSQSLL-ELWRRRG------PIWQEAPQLPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLERYV 476
Cdd:cd17972    22 PLAFATPEQISMDLKnELMYQREqdhnlqQILQERELLPVKKFREEILEAISNNPVVIIRGATGCGKTTQVPQYILDDFI 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  477 TEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRRNVGFQVRLESKPPARGGALLFCTVGILLRKLQSnpSLEGVSHV 556
Cdd:cd17972   102 QNDRAAECNIVVTQPRRISAVSVAERVAFERGEEVGKSCGYSVRFESVLPRPHASILFCTVGVLLRKLEA--GIRGISHV 179

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 568964222  557 IVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSATGDNERFSRYFGGCPVIKV 611
Cdd:cd17972   180 IVDEIHERDINTDFLLVVLRDVVQAYPDLRVILMSATIDTSMFCEYFFNCPVIEV 234
DEXHc_DHX36 cd17981
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ...
 434-611 9.19e-63

DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350739 [Multi-domain]  Cd Length: 180  Bit Score: 211.24  E-value: 9.19e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  434 LPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARCNVIITQPRRISAVSVAQRVSHELGPS--L 511
Cdd:cd17981     1 LPSYGMKQEIINMIDNNQVTVISGETGCGKTTQVTQFILDDAIERGKGSSCRIVCTQPRRISAISVAERVAAERAEScgL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  512 RRNVGFQVRLESKPPARGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMS 591
Cdd:cd17981    81 GNSTGYQIRLESRKPRKQGSILYCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNLQSDVLMGIVKDLLPFRSDLKVILMS 160

                         170       180
                  ....*....|....*....|
gi 568964222  592 ATGDNERFSRYFGGCPVIKV 611
Cdd:cd17981   161 ATLNAEKFSDYFNNCPMIHI 180
DEXHc_DHX57 cd17985
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ...
 426-611 5.75e-61

DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350743 [Multi-domain]  Cd Length: 177  Bit Score: 206.23  E-value: 5.75e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  426 PIWQEapqlpvdphRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARCNVIITQPRRISAVSVAQRVSH 505
Cdd:cd17985     2 PAWQE---------RETILELLEKHQVLVISGMTGCGKTTQIPQFILDNSLQGPPLPVANIICTQPRRISAISVAERVAQ 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  506 ELGPSLRRNVGFQVRLESKPPArGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPAL 585
Cdd:cd17985    73 ERAERVGQSVGYQIRLESVKSS-ATRLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQRPDL 151

                         170       180
                  ....*....|....*....|....*.
gi 568964222  586 RLVLMSATGDNERFSRYFGGCPVIKV 611
Cdd:cd17985   152 KVILMSATLNAELFSDYFNSCPVIHI 177
DEXHc_DHX29 cd17975
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ...
 434-611 1.77e-59

DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350733 [Multi-domain]  Cd Length: 183  Bit Score: 202.07  E-value: 1.77e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  434 LPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLERYV-TEGRGARCNVIITQPRRISAVSVAQRVSHELG---- 508
Cdd:cd17975     1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLLEDLLlNGGTAQKCNIVCTQPRRISAMSLATRVCEELGcesg 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  509 PSLRRNV-GFQVRLESKPpARGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRL 587
Cdd:cd17975    81 PGGKNSLcGYQIRMESRT-GEATRLLYCTTGVLLRKLQEDGLLSSISHIIVDEVHERSVQSDFLLIILKEILHKRSDLHL 159

                         170       180
                  ....*....|....*....|....
gi 568964222  588 VLMSATGDNERFSRYFGGCPVIKV 611
Cdd:cd17975   160 ILMSATVDCEKFSSYFTHCPILRI 183
DEXHc_YTHDC2 cd17987
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ...
 434-611 1.00e-52

DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350745 [Multi-domain]  Cd Length: 176  Bit Score: 182.34  E-value: 1.00e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  434 LPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLERyvTEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRR 513
Cdd:cd17987     1 LPVFEKQEQIVRIIKENKVVLIVGETGSGKTTQIPQFLLDD--CYANGIPCRIFCTQPRRLAAIAVAERVAAERGEKIGQ 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  514 NVGFQVRLESKPPARGgALLFCTVGILLRKLQSNPS-LEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSA 592
Cdd:cd17987    79 TVGYQIRLESRVSPKT-LLTFCTNGVLLRTLMAGDSaLSTVTHVIVDEVHERDRFSDFLLTKLRDILQKHPNLKLILSSA 157

                         170
                  ....*....|....*....
gi 568964222  593 TGDNERFSRYFGGCPVIKV 611
Cdd:cd17987   158 ALDVNLFIRYFGSCPVIYI 176
DEXHc_TDRD9 cd17988
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ...
 434-618 1.72e-51

DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350746 [Multi-domain]  Cd Length: 180  Bit Score: 179.23  E-value: 1.72e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  434 LPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTegRGARCNVIITQPRRISAVSVAQRVSHELGPSLRR 513
Cdd:cd17988     1 LPIYAKREEILSLIEANSVVIIKGATGCGKTTQLPQFILDHYYK--RGKYCNIVVTQPRRIAAISIARRVSQEREWTLGS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  514 NVGFQVRLEsKPPARGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPA-LRLVLMSA 592
Cdd:cd17988    79 LVGYQVGLE-RPASEETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVHERDQELDFLLLVVRRLLRTNSRhVKIILMSA 157

                         170       180
                  ....*....|....*....|....*.
gi 568964222  593 TGDNERFSRYFGgcpVIKVPGFMYPV 618
Cdd:cd17988   158 TISCKEFADYFT---TPNNPAYVFEV 180
DEXHc_DHX33 cd17978
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ...
 434-609 8.58e-50

DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438710 [Multi-domain]  Cd Length: 178  Bit Score: 174.08  E-value: 8.58e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  434 LPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRgarcnVI-ITQPRRISAVSVAQRVSHELGPSLR 512
Cdd:cd17978     1 LPIYSARKRLLEELRKHDTVIIIGETGSGKTTQIPQYLYEAGFARGG-----MIgITQPRRVAAVSVAKRVAEEMGVELG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  513 RNVGFQVRLESKpPARGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLN-----PALRL 587
Cdd:cd17978    76 QLVGYSVRFDDV-TSEETRIKYMTDGMLLREAIGDPLLSKYSVIILDEAHERTVHTDVLFGLVKSAQRRRkeqklSPLKV 154

                         170       180
                  ....*....|....*....|..
gi 568964222  588 VLMSATGDNERFSRYFGGCPVI 609
Cdd:cd17978   155 IIMSATLDADLFSEYFNGAPVL 176
DEXHc_DHX34 cd17979
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ...
 434-611 3.47e-49

DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350737 [Multi-domain]  Cd Length: 170  Bit Score: 172.24  E-value: 3.47e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  434 LPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTegrgarcNVIITQPRRISAVSVAQRVSHELGPSLRR 513
Cdd:cd17979     1 LPIAQYREKIIELLKTHQVVIVAGDTGCGKSTQVPQYLLAAGFR-------HIACTQPRRIACISLAKRVAFESLNQYGS 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  514 NVGFQVRLESKPPARGgALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSAT 593
Cdd:cd17979    74 KVAYQIRFERTRTLAT-KLLFLTEGLLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRCLLRLRPDLKLILMSAT 152

                         170
                  ....*....|....*...
gi 568964222  594 GDNERFSRYFGGCPVIKV 611
Cdd:cd17979   153 INIELFSGYFEGAPVVQV 170
DEXHc_DHX15 cd17973
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ...
 427-611 5.87e-46

DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438709 [Multi-domain]  Cd Length: 187  Bit Score: 163.74  E-value: 5.87e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  427 IWQEAPQLPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARcnVIITQPRRISAVSVAQRVSHE 506
Cdd:cd17973     6 ILEKRRELPVWEQKEDFLKLLKNNQILVLVGETGSGKTTQIPQFVLDDELPHQPKKL--VACTQPRRVAAMSVAQRVAEE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  507 LGPSLRRNVGFQVRLESKPPARGgALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALR 586
Cdd:cd17973    84 MDVKLGEEVGYSIRFEDCSSAKT-ILKYMTDGMLLREAMSDPLLSRYSVIILDEAHERTLATDILMGLLKEVVRRRPDLK 162

                         170       180
                  ....*....|....*....|....*
gi 568964222  587 LVLMSATGDNERFSRYFGGCPVIKV 611
Cdd:cd17973   163 LIVMSATLDAGKFQKYFDNAPLLKV 187
DEXHc_DHX16 cd17974
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ...
 434-611 7.53e-46

DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350732 [Multi-domain]  Cd Length: 174  Bit Score: 162.67  E-value: 7.53e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  434 LPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARCnviITQPRRISAVSVAQRVSHELGPSLRR 513
Cdd:cd17974     1 LPVYPYRDDLLAAVKEHQVLIIVGETGSGKTTQIPQYLHEAGYTKGGGKIG---CTQPRRVAAMSVAARVAEEMGVKLGN 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  514 NVGFQVRLESKPPARGgALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSAT 593
Cdd:cd17974    78 EVGYSIRFEDCTSEKT-VLKYMTDGMLLREFLTEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPDLKLLISSAT 156

                         170
                  ....*....|....*...
gi 568964222  594 GDNERFSRYFGGCPVIKV 611
Cdd:cd17974   157 MDAEKFSAFFDDAPIFRI 174
DEXHc_HrpB cd17990
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ...
 434-611 3.32e-45

DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438711 [Multi-domain]  Cd Length: 174  Bit Score: 160.96  E-value: 3.32e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  434 LPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRgarcNVIITQPRRISAVSVAQRVSHELGPSLRR 513
Cdd:cd17990     1 LPIAAVLPALRAALDAGGQVVLEAPPGAGKTTRVPLALLAELWIAGG----KIIVLEPRRVAARAAARRLATLLGEAPGE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  514 NVGFQVRLESKPpARGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQR-LNPALRLVLMSA 592
Cdd:cd17990    77 TVGYRVRGESRV-GRRTRVEVVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLEVQQlLRDDLRLLAMSA 155

                         170
                  ....*....|....*....
gi 568964222  593 TGDNERFSRYFGGCPVIKV 611
Cdd:cd17990   156 TLDGDGLAALLPEAPVVES 174
DEXHc_HrpA cd17989
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ...
 434-611 4.02e-45

DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350747 [Multi-domain]  Cd Length: 173  Bit Score: 160.70  E-value: 4.02e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  434 LPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLERyvteGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRR 513
Cdd:cd17989     1 LPVSQKRDEIAKAIAENQVVIIAGETGSGKTTQLPKICLEL----GRGIRGLIGHTQPRRLAARSVAERIAEELKTELGG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  514 NVGFQVRLESKPPARGGALLFcTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSAT 593
Cdd:cd17989    77 AVGYKVRFTDQTSDETCVKLM-TDGILLAETQTDRYLRAYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKVIITSAT 155

                         170
                  ....*....|....*...
gi 568964222  594 GDNERFSRYFGGCPVIKV 611
Cdd:cd17989   156 IDAERFSRHFNNAPIIEV 173
DEXHc_DHX35 cd17980
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ...
 434-603 4.90e-44

DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350738 [Multi-domain]  Cd Length: 185  Bit Score: 158.02  E-value: 4.90e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  434 LPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLER-YVTEGRgarcNVIITQPRRISAVSVAQRVSHELGPSLR 512
Cdd:cd17980     1 LPVFKLRNHILYLVENYQTIVIVGETGCGKSTQIPQYLAEAgWTAGGR----VVGCTQPRRVAAVTVAGRVAEEMGAVLG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  513 RNVGFQVRLESKPPARGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSA 592
Cdd:cd17980    77 HEVGYCIRFDDCTDPQATRIKFLTDGMLVREMMLDPLLTKYSVIMLDEAHERTLYTDILIGLLKKIQKKRGDLRLIVASA 156

                         170
                  ....*....|.
gi 568964222  593 TGDNERFSRYF 603
Cdd:cd17980   157 TLDAEKFRDFF 167
DEXHc_DHX37 cd17982
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ...
 434-611 1.92e-43

DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350740 [Multi-domain]  Cd Length: 191  Bit Score: 156.36  E-value: 1.92e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  434 LPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLERYVTEGRGARCNVI-ITQPRRISAVSVAQRVSHELGpSLR 512
Cdd:cd17982     1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQFLYEAGFGSPESDNPGMIgITQPRRVAAVSMAKRVAEELN-VFG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  513 RNVGFQVRLESKpPARGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILL-----------KGLQRL 581
Cdd:cd17982    80 KEVSYQIRYDST-VSENTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTDILIGMLsrivplraklyLQDQTV 158

                         170       180       190
                  ....*....|....*....|....*....|....
gi 568964222  582 NPaLRLVLMSATGDNERFS---RYFGGCP-VIKV 611
Cdd:cd17982   159 KP-LKLVIMSATLRVEDFTenkLLFPRPPpVIKV 191
DEXHc_DHX8 cd17971
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ...
 434-612 4.70e-42

DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350729 [Multi-domain]  Cd Length: 179  Bit Score: 152.25  E-value: 4.70e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  434 LPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLEryvtEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRR 513
Cdd:cd17971     6 LPIYKLKEQLIQAVHDNQILVVIGETGSGKTTQITQYLAE----AGYTSRGKIGCTQPRRVAAMSVAKRVAEEFGCCLGQ 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  514 NVGFQVRLESKPpARGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSAT 593
Cdd:cd17971    82 EVGYTIRFEDCT-SPETVIKYMTDGMLLRECLIDPDLSQYSVIMLDEAHERTIHTDVLFGLLKKTVQKRPDLKLIVTSAT 160

                         170
                  ....*....|....*....
gi 568964222  594 GDNERFSRYFGGCPVIKVP 612
Cdd:cd17971   161 LDAVKFSQYFYEAPIFTIP 179
DEXHc_DHX38 cd17983
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ...
 434-611 1.25e-38

DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350741 [Multi-domain]  Cd Length: 173  Bit Score: 141.83  E-value: 1.25e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  434 LPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLEryvtEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRR 513
Cdd:cd17983     1 LPIFAVRQELLNVIRDNNVVIVVGETGSGKTTQLTQYLHE----DGYTDYGMIGCTQPRRVAAMSVAKRVSEEMGVELGE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  514 NVGFQVRLESKPPARGgALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSAT 593
Cdd:cd17983    77 EVGYAIRFEDCTSENT-VIKYMTDGILLRESLRDPDLDKYSAIIMDEAHERSLNTDVLFGLLREVVARRRDLKLIVTSAT 155

                         170
                  ....*....|....*...
gi 568964222  594 GDNERFSRYFGGCPVIKV 611
Cdd:cd17983   156 MDADKFADFFGNVPIFTI 173
DEXHc_DHX40 cd17984
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ...
 434-611 3.12e-38

DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350742 [Multi-domain]  Cd Length: 178  Bit Score: 141.15  E-value: 3.12e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  434 LPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLEryvtEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRR 513
Cdd:cd17984     1 LPIQKQRKKLVQAVRDNSFLIVTGNTGSGKTTQLPKYLYE----AGFSQHGMIGVTQPRRVAAISVAQRVAEEMKCTLGS 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  514 NVGFQVRLESKPPARgGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPA-----LRLV 588
Cdd:cd17984    77 KVGYQVRFDDCSSKE-TAIKYMTDGCLLRHILADPNLTKYSVIILDEAHERSLTTDILFGLLKKLFQEKSPnrkehLKVV 155

                         170       180
                  ....*....|....*....|...
gi 568964222  589 LMSATGDNERFSRYFGGCPVIKV 611
Cdd:cd17984   156 VMSATLELAKLSAFFGNCPVFDI 178
DEXHc_DHX32 cd17977
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ...
 434-611 2.36e-27

DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350735 [Multi-domain]  Cd Length: 176  Bit Score: 109.92  E-value: 2.36e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  434 LPVDPHRDTILSAIEQHPVVVISGDTGCGKTTRIPQLLLErYVTEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRR 513
Cdd:cd17977     1 LPVWEAKYEFMESLAHNQIVIVSGDAKTGKSSQIPQWCAE-YCLSAHYQHGVVVCTQVHKQTAVWLALRVADEMDVNIGH 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  514 NVGFQVRLESkPPARGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLMSAT 593
Cdd:cd17977    80 EVGYVIPFEN-CCTNETILRYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKDVLLSRPELKLVIITCP 158

                         170
                  ....*....|....*...
gi 568964222  594 GDNERFSRYFGGCPVIKV 611
Cdd:cd17977   159 HLSSKLLSYYGNVPLIEV 176
DEXDc smart00487
DEAD-like helicases superfamily;
438-617 2.03e-24

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 102.18  E-value: 2.03e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222    438 PHRDTILSAIEQHP-VVVISGDTGCGKTTRIPQLLLERYvteGRGARCNVIITQPRRISAVSVAQRVSHELGPSLRRNVG 516
Cdd:smart00487   11 PYQKEAIEALLSGLrDVILAAPTGSGKTLAALLPALEAL---KRGKGGRVLVLVPTRELAEQWAEELKKLGPSLGLKVVG 87

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222    517 FQVRLESKPPAR-----GGALLFCTVGILLRKLQSNP-SLEGVSHVIVDEVHERDvNTDFLLILLKGLQRLNPALRLVLM 590
Cdd:smart00487   88 LYGGDSKREQLRklesgKTDILVTTPGRLLDLLENDKlSLSNVDLVILDEAHRLL-DGGFGDQLEKLLKLLPKNVQLLLL 166

                           170       180
                    ....*....|....*....|....*....
gi 568964222    591 SAT--GDNERFSRYFGGCPVIKVPGFMYP 617
Cdd:smart00487  167 SATppEEIENLLELFLNDPVFIDVGFTPL 195
DEXQc_DQX1 cd17986
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ...
 434-611 1.68e-21

DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350744 [Multi-domain]  Cd Length: 177  Bit Score: 93.04  E-value: 1.68e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  434 LPVDPHRDTILSAIEQHP-VVVISGDTGCGKTTRIPQLLLErYVTEGRGARCNVIITQPRRISAVSVAQRVSHELGPSLR 512
Cdd:cd17986     1 LPIWAAKFTFLEQLESPSgIVLVSGEPGSGKSTQVPQWCAE-FALSRGFQKGQVTVTQPHPLAARSLALRVADEMDLNLG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  513 RNVGFQVRLE--SKPPArggALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPALRLVLM 590
Cdd:cd17986    80 HEVGYSIPQEdcTGPNT---ILRFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLKDVRLQRPELRVVVV 156

                         170       180
                  ....*....|....*....|.
gi 568964222  591 SATGDNERFSRYFGGCPVIKV 611
Cdd:cd17986   157 TSPALEPKLRAFWGNPPVVHV 177
PHA02653 PHA02653
RNA helicase NPH-II; Provisional
 443-789 4.54e-18

RNA helicase NPH-II; Provisional


Pssm-ID: 177443 [Multi-domain]  Cd Length: 675  Bit Score: 89.65  E-value: 4.54e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  443 ILSAIEQHPVVVISGDTGCGKTTRIPQLLLE-RYV---TEGRGARCNVIITQPRRISAVSVAQRVSHelGPSLRRNVGFQ 518
Cdd:PHA02653  172 IFEAWISRKPVVLTGGTGVGKTSQVPKLLLWfNYLfggFDNLDKIDPNFIERPIVLSLPRVALVRLH--SITLLKSLGFD 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  519 --------VRLESKPPA------RGGALLFCTvgillRKLQSNpSLEGVSHVIVDEVHERDVNTDFLL-ILLKGLQRLNp 583
Cdd:PHA02653  250 eidgspisLKYGSIPDElintnpKPYGLVFST-----HKLTLN-KLFDYGTVIIDEVHEHDQIGDIIIaVARKHIDKIR- 322

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  584 alRLVLMSAT--GDNERFSRYFGGCPVIKVPGF-MYPVKEHYLEDilaklgKHQYPHRHRHHESEDecaldldlvtDLVL 660
Cdd:PHA02653  323 --SLFLMTATleDDRDRIKEFFPNPAFVHIPGGtLFPISEVYVKN------KYNPKNKRAYIEEEK----------KNIV 384

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  661 HI--DARGEPG--GILcFLPGWQEIKGVQQRLQEALgmheSKYLILPVHSNIPMMDQ--KAIFQQPPLgvrKIVLATNIA 734
Cdd:PHA02653  385 TAlkKYTPPKGssGIV-FVASVSQCEEYKKYLEKRL----PIYDFYIIHGKVPNIDEilEKVYSSKNP---SIIISTPYL 456

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568964222  735 ETSITVNDIVHVVDSG-LHKEERYDLKtkvscleTVWVSRANVIQRRGRAGRCQSG 789
Cdd:PHA02653  457 ESSVTIRNATHVYDTGrVYVPEPFGGK-------EMFISKSMRTQRKGRVGRVSPG 505
HA2 pfam04408
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ...
 851-939 4.00e-17

Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 461295 [Multi-domain]  Cd Length: 104  Bit Score: 78.05  E-value: 4.00e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222   851 AVILLQEIGVLDQREYLTTLGQRLAHISTDPRLAKAIVLAAIFRCLHPLLVVVSCLT-RDPFSSSLQ------------- 916
Cdd:pfam04408    1 ALELLYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSvRDPFVQPNFldprsaakaarrr 80

                           90       100
                   ....*....|....*....|....
gi 568964222   917 NRAEVDKVKALLSH-DSGSDHLAF 939
Cdd:pfam04408   81 RRAADEKARAKFARlDLEGDHLTL 104
HA2 smart00847
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ...
 857-940 7.63e-17

Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 214852 [Multi-domain]  Cd Length: 82  Bit Score: 76.54  E-value: 7.63e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222    857 EIGVLDQREYLTTLGQRLAHISTDPRLAKAIVLAAIFRCLHPLLVVVSCLTRDPFSSSlQNRAEVDKVKALLSHDsGSDH 936
Cdd:smart00847    1 ELGALDDDGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPRPK-EKREDADAARRRFADP-ESDH 78


                    ....
gi 568964222    937 LAFV 940
Cdd:smart00847   79 LTLL 82
SF2-N cd00046
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ...
 450-593 1.51e-16

N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.


Pssm-ID: 350668 [Multi-domain]  Cd Length: 146  Bit Score: 77.83  E-value: 1.51e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  450 HPVVVISGDTGCGKTTRIPQLLLERYVTegrgARCNVIITQPRRISAVSVAQRVSHELGPSLRrnVGFQVRLESKPPARG 529
Cdd:cd00046     1 GENVLITAPTGSGKTLAALLAALLLLLK----KGKKVLVLVPTKALALQTAERLRELFGPGIR--VAVLVGGSSAEEREK 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568964222  530 GA-----LLFCTVGILLRKLQSN--PSLEGVSHVIVDEVHERDVNTDFLLIL-LKGLQRLNPALRLVLMSAT 593
Cdd:cd00046    75 NKlgdadIIIATPDMLLNLLLREdrLFLKDLKLIIVDEAHALLIDSRGALILdLAVRKAGLKNAQVILLSAT 146
HELICc smart00490
helicase superfamily c-terminal domain;
686-785 1.07e-12

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 64.54  E-value: 1.07e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222    686 QRLQEALGMHesKYLILPVHSNIPMMDQKAIFQQPPLGVRKIVLATNIAETSITVNDIVHVVDSGLhkeerydlktkvsc 765
Cdd:smart00490    1 EELAELLKEL--GIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDL-------------- 64

                            90       100
                    ....*....|....*....|
gi 568964222    766 letvWVSRANVIQRRGRAGR 785
Cdd:smart00490   65 ----PWSPASYIQRIGRAGR 80
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
 453-593 4.60e-11

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 62.65  E-value: 4.60e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222   453 VVISGDTGCGKTT--RIPqlLLERYVTEGRGARcnVIITQPRRISA---VSVAQRVSHELGPSLRRNVGFQVRLESKPPA 527
Cdd:pfam00270   17 VLVQAPTGSGKTLafLLP--ALEALDKLDNGPQ--ALVLAPTRELAeqiYEELKKLGKGLGLKVASLLGGDSRKEQLEKL 92

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568964222   528 RGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNtDFLLILLKGLQRLNPALRLVLMSAT 593
Cdd:pfam00270   93 KGPDILVGTPGRLLDLLQERKLLKNLKLLVLDEAHRLLDM-GFGPDLEEILRRLPKKRQILLLSAT 157
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 657-785 1.79e-10

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 59.15  E-value: 1.79e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222   657 DLVLHIDARGEPGGILCFLPGWQEIKGvqQRLQEALGmheskYLILPVHSNIPMMDQKAIFQQPPLGVRKIVLATNIAET 736
Cdd:pfam00271    4 EALLELLKKERGGKVLIFSQTKKTLEA--ELLLEKEG-----IKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAER 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 568964222   737 SITVNDIVHVVDSGLHKeerydlktkvscletvwvSRANVIQRRGRAGR 785
Cdd:pfam00271   77 GLDLPDVDLVINYDLPW------------------NPASYIQRIGRAGR 107
OB_NTP_bind pfam07717
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ...
 1015-1102 5.19e-07

Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.


Pssm-ID: 400182 [Multi-domain]  Cd Length: 82  Bit Score: 48.40  E-value: 5.19e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  1015 VKGVLMAGLYPNLiqvrqGKVTRQGKfkpnsvTYRTKSGN--ILLHKSTINREATRLRSRWLTYFMAVKSNgSVFVRDSS 1092
Cdd:pfam07717    1 LRAALAAGLYPNV-----ARRDPKGK------GYTTLSDNqrVFIHPSSVLFNEKTFPPEWVVYQELVETT-KVYIRTVT 68

                           90
                   ....*....|
gi 568964222  1093 QVHPLAVLLL 1102
Cdd:pfam07717   69 AISPEWLLLF 78
DEXHc_Ski2 cd17921
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ...
 435-610 2.95e-05

DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350679 [Multi-domain]  Cd Length: 181  Bit Score: 46.10  E-value: 2.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  435 PVDPH-RDTILSAIEQHPVVVISGDTGCGKTTrIPQLLLERYVTEGRGarcNVIITQPRRisAVS--VAQRVSHELGPSl 511
Cdd:cd17921     1 LLNPIqREALRALYLSGDSVLVSAPTSSGKTL-IAELAILRALATSGG---KAVYIAPTR--ALVnqKEADLRERFGPL- 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  512 rrnvGFQVRL------ESKPPARGGALLFCT---VGILLRKLqSNPSLEGVSHVIVDEVH-----ERDVntdFLLILLKG 577
Cdd:cd17921    74 ----GKNVGLltgdpsVNKLLLAEADILVATpekLDLLLRNG-GERLIQDVRLVVVDEAHligdgERGV---VLELLLSR 145

                         170       180       190
                  ....*....|....*....|....*....|....
gi 568964222  578 LQRLNPALRLVLMSATGDN-ERFSRYFGGCPVIK 610
Cdd:cd17921   146 LLRINKNARFVGLSATLPNaEDLAEWLGVEDLIR 179
SF2_C cd18785
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ...
 726-796 3.37e-03

C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350172 [Multi-domain]  Cd Length: 77  Bit Score: 37.68  E-value: 3.37e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568964222  726 KIVLATNIAETSITVNDIVHVVdsglhkeerydlktkvscLETVWVSRANVIQRRGRAGR-CQSGFAYHLFP 796
Cdd:cd18785    24 EILVATNVLGEGIDVPSLDTVI------------------FFDPPSSAASYIQRVGRAGRgGKDEGEVILFV 77
SSL2 COG1061
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
441-747 9.28e-03

Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];


Pssm-ID: 440681 [Multi-domain]  Cd Length: 566  Bit Score: 40.01  E-value: 9.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  441 DTILSAIEQ-HPVVVISGDTGCGKTtRIPQLLLERYVTEGRgarcnVIITQPRRISAVSVAQRVSHELGpslrrnvGFQV 519
Cdd:COG1061    90 EALLAALERgGGRGLVVAPTGTGKT-VLALALAAELLRGKR-----VLVLVPRRELLEQWAEELRRFLG-------DPLA 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  520 RLESKPPARGGalLFCTVGILLRKLQSNPSLEGVSHVIVDEVHErdVNTDFlliLLKGLQRLNPALRLvLMSAT-----G 594
Cdd:COG1061   157 GGGKKDSDAPI--TVATYQSLARRAHLDELGDRFGLVIIDEAHH--AGAPS---YRRILEAFPAAYRL-GLTATpfrsdG 228

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  595 DNERFSRYFGgcPVIKVP-------GFmypVKEHYLEDILAKLGKHQYPHRHRHHESEDECALDLDLVTDLVLHI-DARG 666
Cdd:COG1061   229 REILLFLFDG--IVYEYSlkeaiedGY---LAPPEYYGIRVDLTDERAEYDALSERLREALAADAERKDKILRELlREHP 303

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222  667 EPGGILCFLPGWQEIKGVQQRLQEAlgmhesKYLILPVHSNIPMMDQKAIFQQPPLGVRKIVLATNIAETSITVNDIVHV 746
Cdd:COG1061   304 DDRKTLVFCSSVDHAEALAELLNEA------GIRAAVVTGDTPKKEREEILEAFRDGELRILVTVDVLNEGVDVPRLDVA 377


                  .
gi 568964222  747 V 747
Cdd:COG1061   378 I 378
AAA_16 pfam13191
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ...
 437-589 9.95e-03

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 433025 [Multi-domain]  Cd Length: 167  Bit Score: 38.25  E-value: 9.95e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222   437 DPHRDTILSAIEQH-----PVVVISGDTGCGKTT---RIPQLLLER--YVTEGRGARCNVIITQPRRISAVSVAQRVSHE 506
Cdd:pfam13191    6 EEELEQLLDALDRVrsgrpPSVLLTGEAGTGKTTllrELLRALERDggYFLRGKCDENLPYSPLLEALTREGLLRQLLDE 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964222   507 LGPSLRRNVGFQVRLESKP-PARGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTdflLILLKGLQRLNPAL 585
Cdd:pfam13191   86 LESSLLEAWRAALLEALAPvPELPGDLAERLLDLLLRLLDLLARGERPLVLVLDDLQWADEAS---LQLLAALLRLLESL 162


                   ....
gi 568964222   586 RLVL 589
Cdd:pfam13191  163 PLLV 166
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH