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Conserved domains on  [gi|568956493|ref|XP_006530912|]
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zinc finger protein 90 isoform X1 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
189-617 1.00e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 1.00e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956493 189 TQSNILAKKKPYKCDKCRKSFihrsSLNKHEKIHKGDPysngtdqgaqSGRKHHECAD--CGKTFLWRTQLTEHQRIHTG 266
Cdd:COG5048   23 TLKSLSNAPRPDSCPNCTDSF----SRLEHLTRHIRSH----------TGEKPSQCSYsgCDKSFSRPLELSRHLRTHHN 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956493 267 EKPFECNVCGKAFRHSSSLGQHENAHT----GEKPYQCSLCGKAFQRSSSLVQHQRIHTGEKPYRCNLCGRSFRHSTSLT 342
Cdd:COG5048   89 NPSDLNSKSLPLSNSKASSSSLSSSSSnsndNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLH 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956493 343 -QHEVTHSGEKPfqckecgkafSRCSSLVQHERTHTGEKPFECSICGRAFGQSPSLYKHMRIHKRSKPYQSNNFSLAFVP 421
Cdd:COG5048  169 pPLPANSLSKDP----------SSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPK 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956493 422 NTPLPQGeglLTEVKSYHCNdcgkdfgHITDFSEHQRLHAGENSYGSEQTLLGQQSlshPREKPYQCNVCGKAFKRSTSF 501
Cdd:COG5048  239 SLLSQSP---SSLSSSDSSS-------SASESPRSSLPTASSQSSSPNESDSSSEK---GFSLPIKSKQCNISFSRSSPL 305

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956493 502 IEH--HRIHTGE--KPYECNE--CGEAFSRLSSLTQHERTHTGEKPYECI------------------------------ 545
Cdd:COG5048  306 TRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllnssskfspllnneppqslqqykdlkndk 385

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956493 546 -------DCGKAFSQSSSLIQHERTHTGEKPYECN--ECGRAFRKKTNLHDHQRTHTGEKPYACkeCGRNFSRSSALTKH 616
Cdd:COG5048  386 ksetlsnSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLC--SILKSFRRDLDLSN 463


                 .
gi 568956493 617 H 617
Cdd:COG5048  464 H 464
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
189-617 1.00e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 1.00e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956493 189 TQSNILAKKKPYKCDKCRKSFihrsSLNKHEKIHKGDPysngtdqgaqSGRKHHECAD--CGKTFLWRTQLTEHQRIHTG 266
Cdd:COG5048   23 TLKSLSNAPRPDSCPNCTDSF----SRLEHLTRHIRSH----------TGEKPSQCSYsgCDKSFSRPLELSRHLRTHHN 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956493 267 EKPFECNVCGKAFRHSSSLGQHENAHT----GEKPYQCSLCGKAFQRSSSLVQHQRIHTGEKPYRCNLCGRSFRHSTSLT 342
Cdd:COG5048   89 NPSDLNSKSLPLSNSKASSSSLSSSSSnsndNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLH 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956493 343 -QHEVTHSGEKPfqckecgkafSRCSSLVQHERTHTGEKPFECSICGRAFGQSPSLYKHMRIHKRSKPYQSNNFSLAFVP 421
Cdd:COG5048  169 pPLPANSLSKDP----------SSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPK 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956493 422 NTPLPQGeglLTEVKSYHCNdcgkdfgHITDFSEHQRLHAGENSYGSEQTLLGQQSlshPREKPYQCNVCGKAFKRSTSF 501
Cdd:COG5048  239 SLLSQSP---SSLSSSDSSS-------SASESPRSSLPTASSQSSSPNESDSSSEK---GFSLPIKSKQCNISFSRSSPL 305

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956493 502 IEH--HRIHTGE--KPYECNE--CGEAFSRLSSLTQHERTHTGEKPYECI------------------------------ 545
Cdd:COG5048  306 TRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllnssskfspllnneppqslqqykdlkndk 385

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956493 546 -------DCGKAFSQSSSLIQHERTHTGEKPYECN--ECGRAFRKKTNLHDHQRTHTGEKPYACkeCGRNFSRSSALTKH 616
Cdd:COG5048  386 ksetlsnSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLC--SILKSFRRDLDLSN 463


                 .
gi 568956493 617 H 617
Cdd:COG5048  464 H 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
528-553 7.24e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 7.24e-05
                          10        20
                  ....*....|....*....|....*.
gi 568956493  528 SLTQHERTHTGEKPYECIDCGKAFSQ 553
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 352-407 5.60e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.08  E-value: 5.60e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568956493 352 KPFqCKECGKAFSRCSSLVQHERTHTgekpFECSICGRAFGQSPSLYKH-MRIHKRS 407
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVHKET 52
PHA00733 PHA00733
hypothetical protein
 297-344 8.01e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 36.78  E-value: 8.01e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 568956493 297 PYQCSLCGKAFQRSSSLVQHQRIHTGEKpyRCNLCGRSFRHSTSLTQH 344
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
189-617 1.00e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 1.00e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956493 189 TQSNILAKKKPYKCDKCRKSFihrsSLNKHEKIHKGDPysngtdqgaqSGRKHHECAD--CGKTFLWRTQLTEHQRIHTG 266
Cdd:COG5048   23 TLKSLSNAPRPDSCPNCTDSF----SRLEHLTRHIRSH----------TGEKPSQCSYsgCDKSFSRPLELSRHLRTHHN 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956493 267 EKPFECNVCGKAFRHSSSLGQHENAHT----GEKPYQCSLCGKAFQRSSSLVQHQRIHTGEKPYRCNLCGRSFRHSTSLT 342
Cdd:COG5048   89 NPSDLNSKSLPLSNSKASSSSLSSSSSnsndNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLH 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956493 343 -QHEVTHSGEKPfqckecgkafSRCSSLVQHERTHTGEKPFECSICGRAFGQSPSLYKHMRIHKRSKPYQSNNFSLAFVP 421
Cdd:COG5048  169 pPLPANSLSKDP----------SSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPK 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956493 422 NTPLPQGeglLTEVKSYHCNdcgkdfgHITDFSEHQRLHAGENSYGSEQTLLGQQSlshPREKPYQCNVCGKAFKRSTSF 501
Cdd:COG5048  239 SLLSQSP---SSLSSSDSSS-------SASESPRSSLPTASSQSSSPNESDSSSEK---GFSLPIKSKQCNISFSRSSPL 305

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956493 502 IEH--HRIHTGE--KPYECNE--CGEAFSRLSSLTQHERTHTGEKPYECI------------------------------ 545
Cdd:COG5048  306 TRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllnssskfspllnneppqslqqykdlkndk 385

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956493 546 -------DCGKAFSQSSSLIQHERTHTGEKPYECN--ECGRAFRKKTNLHDHQRTHTGEKPYACkeCGRNFSRSSALTKH 616
Cdd:COG5048  386 ksetlsnSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLC--SILKSFRRDLDLSN 463


                 .
gi 568956493 617 H 617
Cdd:COG5048  464 H 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
268-624 1.41e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.86  E-value: 1.41e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956493 268 KPFECNVCGKAFRHSSSLGQHENAHTGEKPYQCSL--CGKAFQRSSSLVQHQRIHTGEKPYRCNLCGRSFRHSTSLTQHE 345
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956493 346 VTHSGE-KPFQCKECGKAFSRCSSLVQHERTHTGEKPFECSICGRAFGQSP-SLYKHMRIHKRSKPYQSNNFSLAFVPNT 423
Cdd:COG5048  112 SSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqSNSLHPPLPANSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956493 424 PLPqgeglltEVKSYHCNDCGKDFGHITDFSEHQRLH-------AGENSYGSEQTLLGQQ------SLSHPREKPYQCNV 490
Cdd:COG5048  192 VST-------SIPSSSENSPLSSSYSIPSSSSDQNLEnsssslpLTTNSQLSPKSLLSQSpsslssSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956493 491 CGKAFKRSTSFIEHH-RIHTG-EKPYECNECGEAFSRLSSLTQHERT--HTGE--KPYEC--IDCGKAFSQSSSLIQHER 562
Cdd:COG5048  265 LPTASSQSSSPNESDsSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHIL 344

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568956493 563 THTGEKPYEC--NECGRAFRKKTN-----LHDHQRTHTGEKPYAC--KECGRNFSRSSALTKHHRVHARNK 624
Cdd:COG5048  345 LHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFR 415
zf-H2C2_2 pfam13465
Zinc-finger double domain;
528-553 7.24e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 7.24e-05
                          10        20
                  ....*....|....*....|....*.
gi 568956493  528 SLTQHERTHTGEKPYECIDCGKAFSQ 553
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
257-281 2.40e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.40e-04
                          10        20
                  ....*....|....*....|....*
gi 568956493  257 LTEHQRIHTGEKPFECNVCGKAFRH 281
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
312-337 3.99e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.99e-04
                          10        20
                  ....*....|....*....|....*.
gi 568956493  312 SLVQHQRIHTGEKPYRCNLCGRSFRH 337
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 352-407 5.60e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.08  E-value: 5.60e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568956493 352 KPFqCKECGKAFSRCSSLVQHERTHTgekpFECSICGRAFGQSPSLYKH-MRIHKRS 407
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVHKET 52
zf-H2C2_2 pfam13465
Zinc-finger double domain;
556-579 5.63e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.63e-04
                          10        20
                  ....*....|....*....|....
gi 568956493  556 SLIQHERTHTGEKPYECNECGRAF 579
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
340-365 8.66e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.66e-04
                          10        20
                  ....*....|....*....|....*.
gi 568956493  340 SLTQHEVTHSGEKPFQCKECGKAFSR 365
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
368-391 8.92e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.92e-04
                          10        20
                  ....*....|....*....|....
gi 568956493  368 SLVQHERTHTGEKPFECSICGRAF 391
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 266-349 1.13e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956493 266 GEKPFECNV--CGKAFRHSSSLGQHE-NAHtgekpyqcslCGKAFQRSSSLVQHQRIHTGEKPYRCNLCGRSFRHSTSLT 342
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYHMlHGH----------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                 ....*..
gi 568956493 343 QHeVTHS 349
Cdd:COG5189  416 YH-RKHS 421
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
153-394 1.18e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 1.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956493 153 SSLSTDLVPQLDISSSIRPSDCKTFGNNLEHNSELVTQSNILAKKKPYKC----------DKCRKSFIHRSSLNKHEKIH 222
Cdd:COG5048  194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQspsslsssdsSSSASESPRSSLPTASSQSS 273

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956493 223 KGDPYSNGTDQGAQsgrKHHECADCGKTFLWRTQLTEHQR--IHTGE--KPFECNV--CGKAFRHSSSLGQHENAHTGEK 296
Cdd:COG5048  274 SPNESDSSSEKGFS---LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956493 297 PYQCSLC-------GKAFQRSSSLVQHQRIHTGEKPYRC--NLCGRSFRHSTSLTQHEVTHSGEKP--FQCKECGKAFSR 365
Cdd:COG5048  351 PAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNR 430

                        250       260
                 ....*....|....*....|....*....
gi 568956493 366 CSSLVQHERTHTGEKPFECSICGRAFGQS 394
Cdd:COG5048  431 HYNLIPHKKIHTNHAPLLCSILKSFRRDL 459
zf-H2C2_2 pfam13465
Zinc-finger double domain;
503-525 2.36e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.36e-03
                          10        20
                  ....*....|....*....|...
gi 568956493  503 EHHRIHTGEKPYECNECGEAFSR 525
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
552-628 3.42e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 3.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956493 552 SQSSSLIQHERTHTGE----KPYECNECGRAFRKKTNLHDHQRTHTGEKPYACKECGR--NFSRSSALTKHHRVHARNKL 625
Cdd:COG5048   12 NNSVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPS 91


                 ...
gi 568956493 626 QES 628
Cdd:COG5048   92 DLN 94
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 296-344 4.60e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.38  E-value: 4.60e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 568956493 296 KPYqCSLCGKAFQRSSSLVQHQRIHTgekpYRCNLCGRSFRHSTSLTQH 344
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 570-592 5.36e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 5.36e-03
                          10        20
                  ....*....|....*....|...
gi 568956493  570 YECNECGRAFRKKTNLHDHQRTH 592
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 354-376 5.41e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 5.41e-03
                          10        20
                  ....*....|....*....|...
gi 568956493  354 FQCKECGKAFSRCSSLVQHERTH 376
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 598-620 5.85e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 5.85e-03
                          10        20
                  ....*....|....*....|...
gi 568956493  598 YACKECGRNFSRSSALTKHHRVH 620
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
584-609 6.36e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.36e-03
                          10        20
                  ....*....|....*....|....*.
gi 568956493  584 NLHDHQRTHTGEKPYACKECGRNFSR 609
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 297-344 8.01e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 36.78  E-value: 8.01e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 568956493 297 PYQCSLCGKAFQRSSSLVQHQRIHTGEKpyRCNLCGRSFRHSTSLTQH 344
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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