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Conserved domains on  [gi|578821385|ref|XP_006718602|]
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carabin isoform X1 [Homo sapiens]

Protein Classification

TBC domain-containing protein( domain architecture ID 10640016)

TBC (Tre-2/Bub2/Cdc1) domain-containing protein may function as a GTPase activator protein of Rab-like small GTPases

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
89-294 2.40e-66

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


:

Pssm-ID: 214540 [Multi-domain]  Cd Length: 216  Bit Score: 211.40  E-value: 2.40e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821385    89 CRKGIPSALRARCWPLLCGAHV-CQKNSPGTYQELAE--APGDPQWMETIGRDLHRQFPLHEMFVSPQGHGQQGLLQVLK 165
Cdd:smart00164   1 VRKGVPPSLRGVVWKLLLNAQPmDTSADKDLYSRLLKetAPDDKSIVHQIEKDLRRTFPEHSFFQDKEGPGQESLRRVLK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821385   166 AYTLYRPEQGYCQAQGPVAAVLLMHLPPEE-AFWCLVQICEVYLPGYYGPHMEAVRLDAEVFMALLRRLLPHVHKHLQQV 244
Cdd:smart00164  81 AYALYNPEVGYCQGMNFLAAPLLLVMEDEEdAFWCLVKLMERYGPNFYLPDMSGLQLDLLQLDRLVKEYDPDLYKHLKDL 160
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 578821385   245 GVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEGARVLFRVGLTLVRL 294
Cdd:smart00164 161 GITPSLYALRWFLTLFARELPLEIVLRIWDVLFAEGSDFLFRVALALLKL 210
 
Name Accession Description Interval E-value
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
89-294 2.40e-66

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


Pssm-ID: 214540 [Multi-domain]  Cd Length: 216  Bit Score: 211.40  E-value: 2.40e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821385    89 CRKGIPSALRARCWPLLCGAHV-CQKNSPGTYQELAE--APGDPQWMETIGRDLHRQFPLHEMFVSPQGHGQQGLLQVLK 165
Cdd:smart00164   1 VRKGVPPSLRGVVWKLLLNAQPmDTSADKDLYSRLLKetAPDDKSIVHQIEKDLRRTFPEHSFFQDKEGPGQESLRRVLK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821385   166 AYTLYRPEQGYCQAQGPVAAVLLMHLPPEE-AFWCLVQICEVYLPGYYGPHMEAVRLDAEVFMALLRRLLPHVHKHLQQV 244
Cdd:smart00164  81 AYALYNPEVGYCQGMNFLAAPLLLVMEDEEdAFWCLVKLMERYGPNFYLPDMSGLQLDLLQLDRLVKEYDPDLYKHLKDL 160
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 578821385   245 GVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEGARVLFRVGLTLVRL 294
Cdd:smart00164 161 GITPSLYALRWFLTLFARELPLEIVLRIWDVLFAEGSDFLFRVALALLKL 210
RabGAP-TBC pfam00566
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ...
131-294 3.36e-57

Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.


Pssm-ID: 459855  Cd Length: 178  Bit Score: 186.31  E-value: 3.36e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821385  131 WMETIGRDLHRQFPLHEMFVSPQGhgQQGLLQVLKAYTLYRPEQGYCQAQGPVAAVLLM-HLPPEEAFWCLVQICEVY-L 208
Cdd:pfam00566   8 WPEQIEKDVPRTFPHSFFFDNGPG--QNSLRRILKAYSIYNPDVGYCQGMNFIAAPLLLvYLDEEDAFWCFVSLLENYlL 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821385  209 PGYYGPHMEAVRLDAEVFMALLRRLLPHVHKHLQQVGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEGARV-LFRV 287
Cdd:pfam00566  86 RDFYTPDFPGLKRDLYVFEELLKKKLPKLYKHLKELGLDPDLFASQWFLTLFAREFPLSTVLRIWDYFFLEGEKFvLFRV 165

                  ....*..
gi 578821385  288 GLTLVRL 294
Cdd:pfam00566 166 ALAILKR 172
COG5210 COG5210
GTPase-activating protein [General function prediction only];
90-291 5.02e-50

GTPase-activating protein [General function prediction only];


Pssm-ID: 227535 [Multi-domain]  Cd Length: 496  Bit Score: 176.92  E-value: 5.02e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821385  90 RKGIPSALRARCWPLLCGAHVCQKNSPGTYQELAEA------PGDPQWMEtIGRDLHRQFPLHEMFVSPQGHGQQGLLQV 163
Cdd:COG5210  210 RKGIPNELRGDVWEFLLGIGFDLDKNPGLYERLLNLhreakiPTQEIISQ-IEKDLSRTFPDNSLFQTEISIRAENLRRV 288
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821385 164 LKAYTLYRPEQGYCQAQGPVAAVLLMHLPPEE-AFWCLVQICEV-YLPGYYGPHMEAVRLDAEVFMALLRRLLPHVHKHL 241
Cdd:COG5210  289 LKAYSLYNPEVGYVQGMNFLAAPLLLVLESEEqAFWCLVKLLKNyGLPGYFLKNLSGLHRDLKVLDDLVEELDPELYEHL 368
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 578821385 242 QQVGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEGARVLFRVGLTL 291
Cdd:COG5210  369 LREGVVLLMFAFRWFLTLFVREFPLEYALRIWDCLFLEGSSMLFQLALAI 418
 
Name Accession Description Interval E-value
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
89-294 2.40e-66

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


Pssm-ID: 214540 [Multi-domain]  Cd Length: 216  Bit Score: 211.40  E-value: 2.40e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821385    89 CRKGIPSALRARCWPLLCGAHV-CQKNSPGTYQELAE--APGDPQWMETIGRDLHRQFPLHEMFVSPQGHGQQGLLQVLK 165
Cdd:smart00164   1 VRKGVPPSLRGVVWKLLLNAQPmDTSADKDLYSRLLKetAPDDKSIVHQIEKDLRRTFPEHSFFQDKEGPGQESLRRVLK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821385   166 AYTLYRPEQGYCQAQGPVAAVLLMHLPPEE-AFWCLVQICEVYLPGYYGPHMEAVRLDAEVFMALLRRLLPHVHKHLQQV 244
Cdd:smart00164  81 AYALYNPEVGYCQGMNFLAAPLLLVMEDEEdAFWCLVKLMERYGPNFYLPDMSGLQLDLLQLDRLVKEYDPDLYKHLKDL 160
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 578821385   245 GVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEGARVLFRVGLTLVRL 294
Cdd:smart00164 161 GITPSLYALRWFLTLFARELPLEIVLRIWDVLFAEGSDFLFRVALALLKL 210
RabGAP-TBC pfam00566
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ...
131-294 3.36e-57

Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.


Pssm-ID: 459855  Cd Length: 178  Bit Score: 186.31  E-value: 3.36e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821385  131 WMETIGRDLHRQFPLHEMFVSPQGhgQQGLLQVLKAYTLYRPEQGYCQAQGPVAAVLLM-HLPPEEAFWCLVQICEVY-L 208
Cdd:pfam00566   8 WPEQIEKDVPRTFPHSFFFDNGPG--QNSLRRILKAYSIYNPDVGYCQGMNFIAAPLLLvYLDEEDAFWCFVSLLENYlL 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821385  209 PGYYGPHMEAVRLDAEVFMALLRRLLPHVHKHLQQVGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEGARV-LFRV 287
Cdd:pfam00566  86 RDFYTPDFPGLKRDLYVFEELLKKKLPKLYKHLKELGLDPDLFASQWFLTLFAREFPLSTVLRIWDYFFLEGEKFvLFRV 165

                  ....*..
gi 578821385  288 GLTLVRL 294
Cdd:pfam00566 166 ALAILKR 172
COG5210 COG5210
GTPase-activating protein [General function prediction only];
90-291 5.02e-50

GTPase-activating protein [General function prediction only];


Pssm-ID: 227535 [Multi-domain]  Cd Length: 496  Bit Score: 176.92  E-value: 5.02e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821385  90 RKGIPSALRARCWPLLCGAHVCQKNSPGTYQELAEA------PGDPQWMEtIGRDLHRQFPLHEMFVSPQGHGQQGLLQV 163
Cdd:COG5210  210 RKGIPNELRGDVWEFLLGIGFDLDKNPGLYERLLNLhreakiPTQEIISQ-IEKDLSRTFPDNSLFQTEISIRAENLRRV 288
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821385 164 LKAYTLYRPEQGYCQAQGPVAAVLLMHLPPEE-AFWCLVQICEV-YLPGYYGPHMEAVRLDAEVFMALLRRLLPHVHKHL 241
Cdd:COG5210  289 LKAYSLYNPEVGYVQGMNFLAAPLLLVLESEEqAFWCLVKLLKNyGLPGYFLKNLSGLHRDLKVLDDLVEELDPELYEHL 368
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 578821385 242 QQVGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEGARVLFRVGLTL 291
Cdd:COG5210  369 LREGVVLLMFAFRWFLTLFVREFPLEYALRIWDCLFLEGSSMLFQLALAI 418
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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