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Conserved domains on  [gi|578828320|ref|XP_006721027|]
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voltage-dependent T-type calcium channel subunit alpha-1H isoform X4 [Homo sapiens]

Protein Classification

ion transporter( domain architecture ID 11997982)

ion transporter such as a voltage-gated cation channel, which enables the selective translocation of cations such as sodium, calcium, or potassium across cell membranes

CATH:  1.10.287.70
Gene Ontology:  GO:0034220|GO:0005216|GO:0005886|GO:0034702
PubMed:  15816170
TCDB:  1.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 792-1019 1.77e-65

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 222.53  E-value: 1.77e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320   792 SKYFSRGIMMAILVNTLSMGVEYHEQPEE-LTNALEISNIVFTSMFALEMLLKLLACGP-LGYIRNPYNIFDGIIVVISV 869
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320   870 WEIV---GQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSlktD 946
Cdd:pfam00520   81 ISLVlssVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLK---T 157

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578828320   947 TGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSS-WAALYFVALMTFGNYVLFNLLVAILVEGFQ 1019
Cdd:pfam00520  158 WENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEfWAYIYFVSFIILGGFLLLNLFIAVIIDNFQ 231
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 1293-1565 6.45e-57

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 197.87  E-value: 6.45e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320  1293 HKMFDHVVLVFIFLNCVTIALERPDIDPGSTERvFLSVSNYIFTAIFVAEMMVKVVALGLLsgeHAYLQSSWNLLDGLLV 1372
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTT-VLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVV 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320  1373 LVSLVDIVVAMASAGGA-------------KIlgvlrvlrllrtlrplrvISRAPGLKLVVETLISSLRPIGNIVLICCA 1439
Cdd:pfam00520   77 LPSLISLVLSSVGSLSGlrvlrllrllrllRL------------------IRRLEGLRTLVNSLIRSLKSLGNLLLLLLL 138

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320  1440 FFIIFGILGVQLFKGKFYYCEGPDTRNistkaqcraahyrwvrrkYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGv 1519
Cdd:pfam00520  139 FLFIFAIIGYQLFGGKLKTWENPDNGR------------------TNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG- 199

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 578828320  1520 dqqpvqnhNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQ 1565
Cdd:pfam00520  200 --------EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 1616-1847 6.90e-52

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 183.62  E-value: 6.90e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320  1616 SHYLDLFITFIICVNVITMSMEHYNQPKS-LDEALKYCNYVFTIVFVFEAALKLVAFGF-RRFFKDRWNQLDLAIVLLSL 1693
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320  1694 MGITLEEIEmsaalpiNPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGR 1773
Cdd:pfam00520   81 ISLVLSSVG-------SLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGG 153

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578828320  1774 LECSEDNPCEGlsrHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSredkhclsylPALSPVYFVTFVLVA 1847
Cdd:pfam00520  154 KLKTWENPDNG---RTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG----------EFWAYIYFVSFIILG 214
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 99-430 8.89e-45

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 162.82  E-value: 8.89e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320    99 NPWFEHVSMLVIMLNCVTLGMFRPCEDVECgseRCNILEAFDAFIFAFFAVEMVIKMVALGLFgqKCYLGDTWNRLDFFI 178
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP---LTTVLEILDYVFTGIFTLEMLLKIIAAGFK--KRYFRSPWNILDFVV 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320   179 VVAGMMEYSLDGHN--VSLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFfvffifgivgvqlwagll 256
Cdd:pfam00520   76 VLPSLISLVLSSVGslSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLL------------------ 137

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320   257 rnrCFLdsafvrnnnltflrpyyqteegeenpFICSSrrdNGMQkcshipgrreLRMPCTLGWEaytqpqaegvgaarna 336
Cdd:pfam00520  138 ---LFL--------------------------FIFAI---IGYQ----------LFGGKLKTWE---------------- 159

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320   337 cinwnqyynvcrsgdsNPHNGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDA-HSFYNFIYFILLIIVGSFFMINLCL 415
Cdd:pfam00520  160 ----------------NPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGkGEFWAYIYFVSFIILGGFLLLNLFI 223

                          330
                   ....*....|....*
gi 578828320   416 VVIATQFSETKQRES 430
Cdd:pfam00520  224 AVIIDNFQELTERTE 238
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 1885-2341 1.97e-09

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 63.42  E-value: 1.97e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 1885 AQGPGSARRVDADRPP---------LPQESPGARDAPNLVARKVSVSRMLS---------LPNDSYMFRP--VVPASAPH 1944
Cdd:PHA03247 2495 APDPGGGGPPDPDAPPapsrlapaiLPDEPVGEPVHPRMLTWIRGLEELASddagdppppLPPAAPPAAPdrSVPPPRPA 2574

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 1945 PRPLQ-EVEMETYGAGTPLEScASLQIPLAVSSPARSGEPLHALSPRGTARSPSLSRLLCRQEAVHTDSLEGKIDSPRDT 2023
Cdd:PHA03247 2575 PRPSEpAVTSRARRPDAPPQS-ARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPR 2653

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 2024 LDPAEPGEKTPVRPVTQGGSLQ--SPPRSPRPASVRTrkhTFGQRCVSSRPAAPGGEEAEASDPADEEV--------SHI 2093
Cdd:PHA03247 2654 DDPAPGRVSRPRRARRLGRAAQasSPPQRPRRRAARP---TVGSLTSLADPPPPPPTPEPAPHALVSATplppgpaaARQ 2730

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 2094 TSSACPWQPtAEPHGPEASPVAGGERDLRRLYSVDAqgfldkPGRADEQWRPSAELGSGEPGEAKAWGPEAEPALGARRK 2173
Cdd:PHA03247 2731 ASPALPAAP-APPAVPAGPATPGGPARPARPPTTAG------PPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWD 2803

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 2174 KkmSPPCISVEPPAEDE-GSARPSAAEGGSTTLRRRTPSCEATPHRDSLePTEGSGAGGDPAAKGERWGQASC------- 2245
Cdd:PHA03247 2804 P--ADPPAAVLAPAAALpPAASPAGPLPPPTSAQPTAPPPPPGPPPPSL-PLGGSVAPGGDVRRRPPSRSPAAkpaapar 2880

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 2246 -RAEHLTVPSFAFEPLDLGVPSGDPfldgSHSVTPESRASSsgaivplEPPESEPPMPVGDPPEKRRGLyltvPQCPLEK 2324
Cdd:PHA03247 2881 pPVRRLARPAVSRSTESFALPPDQP----ERPPQPQAPPPP-------QPQPQPPPPPQPQPPPPPPPR----PQPPLAP 2945

                         490
                  ....*....|....*..
gi 578828320 2325 PGSPSATPAPGGGADDP 2341
Cdd:PHA03247 2946 TTDPAGAGEPSGAVPQP 2962
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 792-1019 1.77e-65

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 222.53  E-value: 1.77e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320   792 SKYFSRGIMMAILVNTLSMGVEYHEQPEE-LTNALEISNIVFTSMFALEMLLKLLACGP-LGYIRNPYNIFDGIIVVISV 869
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320   870 WEIV---GQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSlktD 946
Cdd:pfam00520   81 ISLVlssVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLK---T 157

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578828320   947 TGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSS-WAALYFVALMTFGNYVLFNLLVAILVEGFQ 1019
Cdd:pfam00520  158 WENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEfWAYIYFVSFIILGGFLLLNLFIAVIIDNFQ 231
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 1293-1565 6.45e-57

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 197.87  E-value: 6.45e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320  1293 HKMFDHVVLVFIFLNCVTIALERPDIDPGSTERvFLSVSNYIFTAIFVAEMMVKVVALGLLsgeHAYLQSSWNLLDGLLV 1372
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTT-VLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVV 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320  1373 LVSLVDIVVAMASAGGA-------------KIlgvlrvlrllrtlrplrvISRAPGLKLVVETLISSLRPIGNIVLICCA 1439
Cdd:pfam00520   77 LPSLISLVLSSVGSLSGlrvlrllrllrllRL------------------IRRLEGLRTLVNSLIRSLKSLGNLLLLLLL 138

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320  1440 FFIIFGILGVQLFKGKFYYCEGPDTRNistkaqcraahyrwvrrkYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGv 1519
Cdd:pfam00520  139 FLFIFAIIGYQLFGGKLKTWENPDNGR------------------TNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG- 199

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 578828320  1520 dqqpvqnhNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQ 1565
Cdd:pfam00520  200 --------EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 1616-1847 6.90e-52

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 183.62  E-value: 6.90e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320  1616 SHYLDLFITFIICVNVITMSMEHYNQPKS-LDEALKYCNYVFTIVFVFEAALKLVAFGF-RRFFKDRWNQLDLAIVLLSL 1693
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320  1694 MGITLEEIEmsaalpiNPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGR 1773
Cdd:pfam00520   81 ISLVLSSVG-------SLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGG 153

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578828320  1774 LECSEDNPCEGlsrHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSredkhclsylPALSPVYFVTFVLVA 1847
Cdd:pfam00520  154 KLKTWENPDNG---RTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG----------EFWAYIYFVSFIILG 214
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 99-430 8.89e-45

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 162.82  E-value: 8.89e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320    99 NPWFEHVSMLVIMLNCVTLGMFRPCEDVECgseRCNILEAFDAFIFAFFAVEMVIKMVALGLFgqKCYLGDTWNRLDFFI 178
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP---LTTVLEILDYVFTGIFTLEMLLKIIAAGFK--KRYFRSPWNILDFVV 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320   179 VVAGMMEYSLDGHN--VSLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFfvffifgivgvqlwagll 256
Cdd:pfam00520   76 VLPSLISLVLSSVGslSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLL------------------ 137

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320   257 rnrCFLdsafvrnnnltflrpyyqteegeenpFICSSrrdNGMQkcshipgrreLRMPCTLGWEaytqpqaegvgaarna 336
Cdd:pfam00520  138 ---LFL--------------------------FIFAI---IGYQ----------LFGGKLKTWE---------------- 159

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320   337 cinwnqyynvcrsgdsNPHNGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDA-HSFYNFIYFILLIIVGSFFMINLCL 415
Cdd:pfam00520  160 ----------------NPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGkGEFWAYIYFVSFIILGGFLLLNLFI 223

                          330
                   ....*....|....*
gi 578828320   416 VVIATQFSETKQRES 430
Cdd:pfam00520  224 AVIIDNFQELTERTE 238
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1885-2341 1.97e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 63.42  E-value: 1.97e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 1885 AQGPGSARRVDADRPP---------LPQESPGARDAPNLVARKVSVSRMLS---------LPNDSYMFRP--VVPASAPH 1944
Cdd:PHA03247 2495 APDPGGGGPPDPDAPPapsrlapaiLPDEPVGEPVHPRMLTWIRGLEELASddagdppppLPPAAPPAAPdrSVPPPRPA 2574

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 1945 PRPLQ-EVEMETYGAGTPLEScASLQIPLAVSSPARSGEPLHALSPRGTARSPSLSRLLCRQEAVHTDSLEGKIDSPRDT 2023
Cdd:PHA03247 2575 PRPSEpAVTSRARRPDAPPQS-ARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPR 2653

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 2024 LDPAEPGEKTPVRPVTQGGSLQ--SPPRSPRPASVRTrkhTFGQRCVSSRPAAPGGEEAEASDPADEEV--------SHI 2093
Cdd:PHA03247 2654 DDPAPGRVSRPRRARRLGRAAQasSPPQRPRRRAARP---TVGSLTSLADPPPPPPTPEPAPHALVSATplppgpaaARQ 2730

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 2094 TSSACPWQPtAEPHGPEASPVAGGERDLRRLYSVDAqgfldkPGRADEQWRPSAELGSGEPGEAKAWGPEAEPALGARRK 2173
Cdd:PHA03247 2731 ASPALPAAP-APPAVPAGPATPGGPARPARPPTTAG------PPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWD 2803

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 2174 KkmSPPCISVEPPAEDE-GSARPSAAEGGSTTLRRRTPSCEATPHRDSLePTEGSGAGGDPAAKGERWGQASC------- 2245
Cdd:PHA03247 2804 P--ADPPAAVLAPAAALpPAASPAGPLPPPTSAQPTAPPPPPGPPPPSL-PLGGSVAPGGDVRRRPPSRSPAAkpaapar 2880

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 2246 -RAEHLTVPSFAFEPLDLGVPSGDPfldgSHSVTPESRASSsgaivplEPPESEPPMPVGDPPEKRRGLyltvPQCPLEK 2324
Cdd:PHA03247 2881 pPVRRLARPAVSRSTESFALPPDQP----ERPPQPQAPPPP-------QPQPQPPPPPQPQPPPPPPPR----PQPPLAP 2945

                         490
                  ....*....|....*..
gi 578828320 2325 PGSPSATPAPGGGADDP 2341
Cdd:PHA03247 2946 TTDPAGAGEPSGAVPQP 2962
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 2019-2175 7.21e-04

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 44.37  E-value: 7.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 2019 SPRDtlDPA----EPGEKTPVRPVTQGGSLQSPPRSPRPASVrtrkhtfgqrcvsSRPAAPGGEEAEASDPADEEVSHIT 2094
Cdd:NF040712  178 TALD--DEArwliDPDFGRPLRPLATVPRLAREPADARPEEV-------------EPAPAAEGAPATDSDPAEAGTPDDL 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 2095 SSA-----CPWQPTAEPHGPEASPVAGGERDLRRLYSVDAQGFLDKPGRADEQW-RPSAELGSGEPGEAKAWGPEAEPAL 2168
Cdd:NF040712  243 ASArrrraGVEQPEDEPVGPGAAPAAEPDEATRDAGEPPAPGAAETPEAAEPPApAPAAPAAPAAPEAEEPARPEPPPAP 322


                  ....*..
gi 578828320 2169 GARRKKK 2175
Cdd:NF040712  323 KPKRRRR 329
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 792-1019 1.77e-65

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 222.53  E-value: 1.77e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320   792 SKYFSRGIMMAILVNTLSMGVEYHEQPEE-LTNALEISNIVFTSMFALEMLLKLLACGP-LGYIRNPYNIFDGIIVVISV 869
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320   870 WEIV---GQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSlktD 946
Cdd:pfam00520   81 ISLVlssVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLK---T 157

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578828320   947 TGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSS-WAALYFVALMTFGNYVLFNLLVAILVEGFQ 1019
Cdd:pfam00520  158 WENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEfWAYIYFVSFIILGGFLLLNLFIAVIIDNFQ 231
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 1293-1565 6.45e-57

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 197.87  E-value: 6.45e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320  1293 HKMFDHVVLVFIFLNCVTIALERPDIDPGSTERvFLSVSNYIFTAIFVAEMMVKVVALGLLsgeHAYLQSSWNLLDGLLV 1372
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTT-VLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVV 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320  1373 LVSLVDIVVAMASAGGA-------------KIlgvlrvlrllrtlrplrvISRAPGLKLVVETLISSLRPIGNIVLICCA 1439
Cdd:pfam00520   77 LPSLISLVLSSVGSLSGlrvlrllrllrllRL------------------IRRLEGLRTLVNSLIRSLKSLGNLLLLLLL 138

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320  1440 FFIIFGILGVQLFKGKFYYCEGPDTRNistkaqcraahyrwvrrkYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGv 1519
Cdd:pfam00520  139 FLFIFAIIGYQLFGGKLKTWENPDNGR------------------TNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG- 199

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 578828320  1520 dqqpvqnhNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQ 1565
Cdd:pfam00520  200 --------EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 1616-1847 6.90e-52

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 183.62  E-value: 6.90e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320  1616 SHYLDLFITFIICVNVITMSMEHYNQPKS-LDEALKYCNYVFTIVFVFEAALKLVAFGF-RRFFKDRWNQLDLAIVLLSL 1693
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320  1694 MGITLEEIEmsaalpiNPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGR 1773
Cdd:pfam00520   81 ISLVLSSVG-------SLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGG 153

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578828320  1774 LECSEDNPCEGlsrHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSredkhclsylPALSPVYFVTFVLVA 1847
Cdd:pfam00520  154 KLKTWENPDNG---RTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG----------EFWAYIYFVSFIILG 214
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 99-430 8.89e-45

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 162.82  E-value: 8.89e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320    99 NPWFEHVSMLVIMLNCVTLGMFRPCEDVECgseRCNILEAFDAFIFAFFAVEMVIKMVALGLFgqKCYLGDTWNRLDFFI 178
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP---LTTVLEILDYVFTGIFTLEMLLKIIAAGFK--KRYFRSPWNILDFVV 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320   179 VVAGMMEYSLDGHN--VSLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFfvffifgivgvqlwagll 256
Cdd:pfam00520   76 VLPSLISLVLSSVGslSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLL------------------ 137

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320   257 rnrCFLdsafvrnnnltflrpyyqteegeenpFICSSrrdNGMQkcshipgrreLRMPCTLGWEaytqpqaegvgaarna 336
Cdd:pfam00520  138 ---LFL--------------------------FIFAI---IGYQ----------LFGGKLKTWE---------------- 159

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320   337 cinwnqyynvcrsgdsNPHNGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDA-HSFYNFIYFILLIIVGSFFMINLCL 415
Cdd:pfam00520  160 ----------------NPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGkGEFWAYIYFVSFIILGGFLLLNLFI 223

                          330
                   ....*....|....*
gi 578828320   416 VVIATQFSETKQRES 430
Cdd:pfam00520  224 AVIIDNFQELTERTE 238
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1885-2341 1.97e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 63.42  E-value: 1.97e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 1885 AQGPGSARRVDADRPP---------LPQESPGARDAPNLVARKVSVSRMLS---------LPNDSYMFRP--VVPASAPH 1944
Cdd:PHA03247 2495 APDPGGGGPPDPDAPPapsrlapaiLPDEPVGEPVHPRMLTWIRGLEELASddagdppppLPPAAPPAAPdrSVPPPRPA 2574

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 1945 PRPLQ-EVEMETYGAGTPLEScASLQIPLAVSSPARSGEPLHALSPRGTARSPSLSRLLCRQEAVHTDSLEGKIDSPRDT 2023
Cdd:PHA03247 2575 PRPSEpAVTSRARRPDAPPQS-ARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPR 2653

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 2024 LDPAEPGEKTPVRPVTQGGSLQ--SPPRSPRPASVRTrkhTFGQRCVSSRPAAPGGEEAEASDPADEEV--------SHI 2093
Cdd:PHA03247 2654 DDPAPGRVSRPRRARRLGRAAQasSPPQRPRRRAARP---TVGSLTSLADPPPPPPTPEPAPHALVSATplppgpaaARQ 2730

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 2094 TSSACPWQPtAEPHGPEASPVAGGERDLRRLYSVDAqgfldkPGRADEQWRPSAELGSGEPGEAKAWGPEAEPALGARRK 2173
Cdd:PHA03247 2731 ASPALPAAP-APPAVPAGPATPGGPARPARPPTTAG------PPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWD 2803

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 2174 KkmSPPCISVEPPAEDE-GSARPSAAEGGSTTLRRRTPSCEATPHRDSLePTEGSGAGGDPAAKGERWGQASC------- 2245
Cdd:PHA03247 2804 P--ADPPAAVLAPAAALpPAASPAGPLPPPTSAQPTAPPPPPGPPPPSL-PLGGSVAPGGDVRRRPPSRSPAAkpaapar 2880

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 2246 -RAEHLTVPSFAFEPLDLGVPSGDPfldgSHSVTPESRASSsgaivplEPPESEPPMPVGDPPEKRRGLyltvPQCPLEK 2324
Cdd:PHA03247 2881 pPVRRLARPAVSRSTESFALPPDQP----ERPPQPQAPPPP-------QPQPQPPPPPQPQPPPPPPPR----PQPPLAP 2945

                         490
                  ....*....|....*..
gi 578828320 2325 PGSPSATPAPGGGADDP 2341
Cdd:PHA03247 2946 TTDPAGAGEPSGAVPQP 2962
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1935-2269 6.14e-09

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 61.73  E-value: 6.14e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 1935 RPVVPASAPHPRPLQEVEMETYGAGTPLESCASLQIPLAVSSPARSGEPlhalSPRGTARSPSLSrllcrQEAVHTdsle 2014
Cdd:PHA03307  119 PTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAA----SSRQAALPLSSP-----EETARA---- 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 2015 gkIDSPRDTLDPAEPGEKTPVRPVTQGGSLQSPPRSPRPASVRTRKHTFGQRCVSSRPAAPG----GEEAEASDPADEEV 2090
Cdd:PHA03307  186 --PSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSgcgwGPENECPLPRPAPI 263

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 2091 SHITS--SACPWQPTAEPHGPEASPVAGGERDLRRLYSVDAQGFLDKPGRADEQWRPSAELG------SGEPGEAKAWGP 2162
Cdd:PHA03307  264 TLPTRiwEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSssstssSSESSRGAAVSP 343

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 2163 EAEPALGARRKKKmSPPCISVEPPAEDEGSARPS--AAEGGSTTLRRRTPSC-EATPHRDSLEPTEGSGAGGDPAAKGER 2239
Cdd:PHA03307  344 GPSPSRSPSPSRP-PPPADPSSPRKRPRPSRAPSspAASAGRPTRRRARAAVaGRARRRDATGRFPAGRPRPSPLDAGAA 422

                         330       340       350
                  ....*....|....*....|....*....|
gi 578828320 2240 WGQASCRaehltvpsfafEPldLGVPSGDP 2269
Cdd:PHA03307  423 SGAFYAR-----------YP--LLTPSGEP 439
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1936-2340 2.52e-07

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 56.33  E-value: 2.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 1936 PVVPASAPHPRPLQEvEMETYGAGTPLESCASLQIPLAVSSPARSGEPLHALSPRGTARSPSlsrllcrqeavhtdsleg 2015
Cdd:PHA03307   54 TVVAGAAACDRFEPP-TGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSP------------------ 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 2016 kiDSPRDTLDPAEPGEKTPVRpvtqggsLQSPPRSPRPASVRTRKHTFGQRCVSSRPAAPGGEEAEASDPADEEVShitS 2095
Cdd:PHA03307  115 --DPPPPTPPPASPPPSPAPD-------LSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEE---T 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 2096 SACPWQPTAEPhgPEASPVAGGERDLRRLYSVDAQGFLD---KPGRADEQWRP-SAELGSGEPGEAKAWGPEAE-----P 2166
Cdd:PHA03307  183 ARAPSSPPAEP--PPSTPPAAASPRPPRRSSPISASASSpapAPGRSAADDAGaSSSDSSSSESSGCGWGPENEcplprP 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 2167 ALGARRKKKM-----------SPPCISVEPPAEDEGSARPSAAEGGSTTLRRRTPSCEATPHRDSLEPTEGSGAGGDPAA 2235
Cdd:PHA03307  261 APITLPTRIWeasgwngpssrPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAA 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 2236 KGErwGQASCRAehltvpsfafepldlGVPSGDPfldGSHSVTPESRASSSGAIVPLEPPESeppmpvGDPPEKRRGLYL 2315
Cdd:PHA03307  341 VSP--GPSPSRS---------------PSPSRPP---PPADPSSPRKRPRPSRAPSSPAASA------GRPTRRRARAAV 394

                         410       420
                  ....*....|....*....|....*.
gi 578828320 2316 TVPQCPLEKPGS-PSATPAPGGGADD 2340
Cdd:PHA03307  395 AGRARRRDATGRfPAGRPRPSPLDAG 420
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
 1654-1846 6.14e-07

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 52.66  E-value: 6.14e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320  1654 YVFTIVFVFEAALKLVAFGfRRFFKDRWNQLDLAIVLLS----------------LMGITLEEIE--------------- 1702
Cdd:pfam08016   18 VVFFLYFVVEEILKIRKHR-PSYLRSVWNLLDLAIVILSvvlivlniyrdfladrLIKSVEASPVtfidfdrvaqldnly 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320  1703 -MSAALPINPTIIRIMRVLRIARVLKLLKmatgmrallDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGrlecsednp 1781
Cdd:pfam08016   97 rIILAFLVFLTWLKLFKVLRFNKTMSLFT---------KTLSRAWKDLAGFALMFVIFFFAYAQFGYLLFG--------- 158

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578828320  1782 ceglSRHATFSNFGMAFLTLFRVSTGD-NWNGImkdtlRECSRedkhclsylpALSPVYFVTFVLV 1846
Cdd:pfam08016  159 ----TQAPNFSNFVKSILTLFRTILGDfGYNEI-----FSGNR----------VLGPLLFLTFVFL 205
dnaA PRK14086
chromosomal replication initiator protein DnaA;
2023-2228 1.09e-04

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 47.51  E-value: 1.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 2023 TLDPA--EPGEKTPVRPVTQGGSLQSPPRSP------RPASVRTRKHTFGQRCVSSRPAAPggEEAEASDPAdeevshit 2094
Cdd:PRK14086   87 TVDPSagEPAPPPPHARRTSEPELPRPGRRPyegyggPRADDRPPGLPRQDQLPTARPAYP--AYQQRPEPG-------- 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 2095 ssacPWQPTAEPHGPEASPVAGGERDlrrLYSVDAQgfldkPGRADEQWRPSAelGSGEPGEAKAWGPEAEPALGARRKK 2174
Cdd:PRK14086  157 ----AWPRAADDYGWQQQRLGFPPRA---PYASPAS-----YAPEQERDREPY--DAGRPEYDQRRRDYDHPRPDWDRPR 222

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 578828320 2175 KMSPPCISVEPPAEDEGSARPSAAEGGSTTLRRRTPSCEATPHRDSlEPTEGSG 2228
Cdd:PRK14086  223 RDRTDRPEPPPGAGHVHRGGPGPPERDDAPVVPIRPSAPGPLAAQP-APAPGPG 275
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 1885-2244 3.03e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 46.13  E-value: 3.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 1885 AQGPGSARRVDADRPPlPQESPGARDAPNLVARKVSVSRMLSLPNDSYMFRPVVPASAPHPRPLQEVEMETYGAGTPLES 1964
Cdd:PRK07764  409 APAPAAAAPAAAAAPA-PAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAA 487

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 1965 CASLQIPLAVSSPARSGEPLHALSPRG---------TARSPSLSRLLCRQEAVHT---DSLEGKIDSPRDTLDPAEPGEK 2032
Cdd:PRK07764  488 PAPAAAPAAPAAPAAPAGADDAATLRErwpeilaavPKRSRKTWAILLPEATVLGvrgDTLVLGFSTGGLARRFASPGNA 567

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 2033 TPVRPVTQ---GGSLQ-----SPPRSPRPASVRTRKHTFGQRCVSSRPAAPGGEEAEASDPADEEVSH----ITSSACPW 2100
Cdd:PRK07764  568 EVLVTALAeelGGDWQveavvGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAApaeaSAAPAPGV 647

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 2101 QPTAEPHGPEASPVAGGERDLRRLYSVDAQGFLDKPGRADEQWRPSAELGSGEPGEAKAWGPEAEPALGARRkkkmsppc 2180
Cdd:PRK07764  648 AAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAA-------- 719

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578828320 2181 isvEPPAEDEGSARPSAAEGGSTTLRRRTPSCEATPHRDSLEPTEGSGAGGDPAAKGERWGQAS 2244
Cdd:PRK07764  720 ---QPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPS 780
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 2026-2342 3.06e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 46.13  E-value: 3.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 2026 PAEPGEKTPVRPVT-QGGSLQSPPRSPRPASVRTRKHTFGQRCVSSRPAA-PGGEEAEASDPADEEVSHITSSACPWQPT 2103
Cdd:PRK07764  415 AAPAAAAAPAPAAApQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAqPAPAPAAAPEPTAAPAPAPPAAPAPAAAP 494

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 2104 AEPHGPEASPVAGGERDLRRL--------------------------------------YSVDAQGFLDkPGRAD----- 2140
Cdd:PRK07764  495 AAPAAPAAPAGADDAATLRERwpeilaavpkrsrktwaillpeatvlgvrgdtlvlgfsTGGLARRFAS-PGNAEvlvta 573

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 2141 ------EQWRPSAELGsGEPGEAKAWGPEAePALGARRKKKMSPPciSVEPPAEDEGSARPSAAEGGSTTLRRRTPSCEA 2214
Cdd:PRK07764  574 laeelgGDWQVEAVVG-PAPGAAGGEGPPA-PASSGPPEEAARPA--APAAPAAPAAPAPAGAAAAPAEASAAPAPGVAA 649

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 2215 TPHRDSLEPTEGSGAGGDPAAKGERWGQASCRAehlTVPSFAFEPLDLGVPSGDPfLDGSHSVTPESRASSSGAIVPLEP 2294
Cdd:PRK07764  650 PEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPP---PAPAPAAPAAPAGAAPAQP-APAPAATPPAGQADDPAAQPPQAA 725

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 578828320 2295 PESEPPMPVGD-----------PPEKRRGLYLTVPQCPLEKPGSPSATPAPGGGADDPV 2342
Cdd:PRK07764  726 QGASAPSPAADdpvplppepddPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEE 784
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
2066-2260 6.16e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 45.25  E-value: 6.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 2066 RCVSSRPAAPGGEEAEASDPADEEVSHITSSACPWQPTAEPHGPEASPVAGGERDLRRLYSVDAQGFLdKPGRADEQWRP 2145
Cdd:PRK12323  359 RMLAFRPGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARR-SPAPEALAAAR 437

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 2146 SAELGSGEPGEAKAWGPEAEPALGARrkkkmsPPCISVEPPAEDEGSARPSAAEGGSttlrrRTPSCEATPHRDSLEPTE 2225
Cdd:PRK12323  438 QASARGPGGAPAPAPAPAAAPAAAAR------PAAAGPRPVAAAAAAAPARAAPAAA-----PAPADDDPPPWEELPPEF 506

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 578828320 2226 GSGAGGDPAAKGERWGQASCRAEHLTVPSFAFEPL 2260
Cdd:PRK12323  507 ASPAPAQPDAAPAGWVAESIPDPATADPDDAFETL 541
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 2019-2175 7.21e-04

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 44.37  E-value: 7.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 2019 SPRDtlDPA----EPGEKTPVRPVTQGGSLQSPPRSPRPASVrtrkhtfgqrcvsSRPAAPGGEEAEASDPADEEVSHIT 2094
Cdd:NF040712  178 TALD--DEArwliDPDFGRPLRPLATVPRLAREPADARPEEV-------------EPAPAAEGAPATDSDPAEAGTPDDL 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 2095 SSA-----CPWQPTAEPHGPEASPVAGGERDLRRLYSVDAQGFLDKPGRADEQW-RPSAELGSGEPGEAKAWGPEAEPAL 2168
Cdd:NF040712  243 ASArrrraGVEQPEDEPVGPGAAPAAEPDEATRDAGEPPAPGAAETPEAAEPPApAPAAPAAPAAPEAEEPARPEPPPAP 322


                  ....*..
gi 578828320 2169 GARRKKK 2175
Cdd:NF040712  323 KPKRRRR 329
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
 875-1018 1.56e-03

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 42.26  E-value: 1.56e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320   875 QADGGLSVLRTFRLLRVLKLVRFlpalRRQLVVLVKTM----DNVATFCTLLMLFIFIFSILGMHLFGCKFSlktdtgdt 950
Cdd:pfam08016   95 LYRIILAFLVFLTWLKLFKVLRF----NKTMSLFTKTLsrawKDLAGFALMFVIFFFAYAQFGYLLFGTQAP-------- 162

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578828320   951 vpdrkNFDSLLWAIVTVFQILtqedWNVVLYNGMASTSSW-AALYFVALMTFGNYVLFNLLVAILVEGF 1018
Cdd:pfam08016  163 -----NFSNFVKSILTLFRTI----LGDFGYNEIFSGNRVlGPLLFLTFVFLVIFILLNLFLAIINDSY 222
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 2026-2222 1.92e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.44  E-value: 1.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 2026 PAEPGEktPVRPVTQGGslQSPPRSPRPASVRTRkhtfgqrcvSSRPAAPGGEEAEASDPADEEVSHITSSACPWQPTAE 2105
Cdd:PRK07764  615 PAAPAA--PAAPAAPAP--AGAAAAPAEASAAPA---------PGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAP 681

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 2106 PHGPEASPVAGGERDLRRlYSVDAQGFLDKPGRADEQW--RPSAELGSGEPGEAKAWG----PEAEPALGARRKKKMSPP 2179
Cdd:PRK07764  682 PPAPAPAAPAAPAGAAPA-QPAPAPAATPPAGQADDPAaqPPQAAQGASAPSPAADDPvplpPEPDDPPDPAGAPAQPPP 760

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 578828320 2180 CISVEPPAEDEGSARPSAAEGGSTTLRRRTPSCEATPHRDSLE 2222
Cdd:PRK07764  761 PPAPAPAAAPAAAPPPSPPSEEEEMAEDDAPSMDDEDRRDAEE 803
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
2019-2210 2.23e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 43.33  E-value: 2.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 2019 SPRDTLDPAEPGEKTPVRPVTQGGSLQSPPRSPRPASVRTRKHTFGQR--CVSSRPAAPGGEEAEASDPADEEVSHITSS 2096
Cdd:PRK12323  396 APAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGpgGAPAPAPAPAAAPAAAARPAAAGPRPVAAA 475

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 2097 ACPWQPTAEPhGPEASPVAGGERDLRRLYSVDAQGFLDKPGRADEQWR--PSAELGSGEPGEAKAWGPEAEPALGARRKK 2174
Cdd:PRK12323  476 AAAAPARAAP-AAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVaeSIPDPATADPDDAFETLAPAPAAAPAPRAA 554

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 578828320 2175 KMSPPCISVEPPAEDEgSARPSAAEGGSTTLRRRTP 2210
Cdd:PRK12323  555 AATEPVVAPRPPRASA-SGLPDMFDGDWPALAARLP 589
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
1988-2244 2.62e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 42.91  E-value: 2.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 1988 SPRGTARSPSLSRLLCRQEAVHTDSLEGKIDSPRDTLDPAEPGEKTPvRPVTQGGS--LQSPPRSPRPASVRTR--KHTF 2063
Cdd:PRK07003  366 GAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAP-KAAAAAAAtrAEAPPAAPAPPATADRgdDAAD 444

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 2064 GQRCVSSRPAAPGGEEAEASDPADEEVSHITSSACPWQPTAEPHGPEASPVAGGERDLRRLYSVDAQGfLDKPGRADE-- 2141
Cdd:PRK07003  445 GDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARA-PAAASREDApa 523

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 2142 -QWRPSAELGSGEPGEAK--AWGPEAEPALGARRKKKMSppcISVEPPAEDEGSARPSAAEGGSTTLRRRTPSCEATPHR 2218
Cdd:PRK07003  524 aAAPPAPEARPPTPAAAApaARAGGAAAALDVLRNAGMR---VSSDRGARAAAAAKPAAAPAAAPKPAAPRVAVQVPTPR 600

                         250       260
                  ....*....|....*....|....*.
gi 578828320 2219 DSLEPTEGSGAGGDPAAKGERWGQAS 2244
Cdd:PRK07003  601 ARAATGDAPPNGAARAEQAAESRGAP 626
PHA03309 PHA03309
transcriptional regulator ICP4; Provisional
 1964-2307 4.20e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 165564 [Multi-domain]  Cd Length: 2033  Bit Score: 42.53  E-value: 4.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 1964 SCASLQIPLAVSSPARSGEPLHALSP--RGTARSPS-----------------LSRLLCRQEAVHTDSLEGKidsprDTL 2024
Cdd:PHA03309 1572 SSASHDRSPSSSSRRRDGRPSSRRRPsrRMSARPPSrppaavilraswryaeeVAREMLDAAASRFDEADGE-----DPL 1646

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 2025 DPAEPGEKtPVRPVT-------QGGSLQSPPRSPRPASvrtrkhtfGQRCVSSRPAApggeeaeASDPADEEVshitssa 2097
Cdd:PHA03309 1647 PPAACGGK-PIAPETlvalceqRGRGPTSLPRAPTPRS--------GEALAAPRRSG-------AKDPRQGQY------- 1703

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 2098 CPWQPTAE-PHGPEASPVAggERDLRRLYSVDAQGFLD----------KPGRADEQWRPSAELGSGEPGEAKAWGPEA-E 2165
Cdd:PHA03309 1704 CPSARRSEaPHSPSPRDVA--LRLLERQQELNRQLLLElrrgsceispSPRRRDAEGRRFGCRQDDDDGYDYEGGRESpE 1781

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 2166 PALGARRKKKMSPPC--------------ISV-EPPAEDEGSARPSAAEGGSTTLRRRTPSCEATPHRDSLEPTEGSGAG 2230
Cdd:PHA03309 1782 RVLGRRQSRRDSVPVrrrsgaancggrwmISAgRSSSSSSSSSSSSSSSPSSRPSRSATPSLSPSPSPPRRAPVDRSRSG 1861

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828320 2231 -----GDPAAKGERWG-QASCRAEHL---TVPSFAFEPLDLGVPSGDPFLDGSHSVTPESRASSSGAIVPLEPPESEPPM 2301
Cdd:PHA03309 1862 rrrerDRPSANPFRWApRQRSRADHSpdgTAPGDAPLNLEDGPGRGRPIWTPSSATTLPSRSGPEDSVDETETEDSAPPA 1941


                  ....*.
gi 578828320 2302 PVGDPP 2307
Cdd:PHA03309 1942 RLAPSP 1947
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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