NCBI Conserved Domain Search

Conserved domains on [gi|602665565|ref|XP_007438367|]

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olfactory receptor 3-like [Python bivittatus]

Protein Classification

olfactory receptor subfamily 1A-like( domain architecture ID 11607089)

olfactory receptor subfamily 1A-like such as human olfactory receptor 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians; belong to the class A rhodopsin-like family of seven-transmembrane G protein-coupled receptors (7TM GPCRs)

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

7tmA_OR1A-like

cd15235

olfactory receptor subfamily 1A and related proteins, member of the class A family of ...

24-304

5.98e-147

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320363 [Multi-domain] Cd Length: 278 Bit Score: 414.31 E-value: 5.98e-147

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  24 EGPLFSLFLFMYLLTFLGNSLIILLILFDAHLCgLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLY 103
Cdd:cd15235    1 QPLLFLLFLAMYLLTLLGNLLIVLLIRSDPRLH-TPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMY 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 104 LLITLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIR 183
Cdd:cd15235   80 FFIAFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQ 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 184 ELLSLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQP 263
Cdd:cd15235  160 PLLKLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQP 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 602665565 264 SSpeRSTSVGTFIASVIFMVITPMLNPVIYSLKNNEVRNAM 304
Cdd:cd15235  240 SS--SYSADKDRVATVMYTVVTPMLNPFIYSLRNKDVKGAL 278

Name

Accession

Description

Interval

E-value

7tmA_OR1A-like

cd15235

olfactory receptor subfamily 1A and related proteins, member of the class A family of ...

24-304

5.98e-147

Pssm-ID: 320363 [Multi-domain] Cd Length: 278 Bit Score: 414.31 E-value: 5.98e-147

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  24 EGPLFSLFLFMYLLTFLGNSLIILLILFDAHLCgLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLY 103
Cdd:cd15235    1 QPLLFLLFLAMYLLTLLGNLLIVLLIRSDPRLH-TPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMY 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 104 LLITLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIR 183
Cdd:cd15235   80 FFIAFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQ 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 184 ELLSLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQP 263
Cdd:cd15235  160 PLLKLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQP 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 602665565 264 SSpeRSTSVGTFIASVIFMVITPMLNPVIYSLKNNEVRNAM 304
Cdd:cd15235  240 SS--SYSADKDRVATVMYTVVTPMLNPFIYSLRNKDVKGAL 278

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

31-307

2.27e-42

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 147.65 E-value: 2.27e-42

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565   31 FLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLITLAN 110
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSL-HQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  111 VDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIRELLSLSC 190
Cdd:pfam13853  80 MESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSC 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  191 SDVSIHQMI-IFIEGASVTLSPLVcILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPSSPERS 269
Cdd:pfam13853 160 ADIKVNNIYgLFVVTSTFGIDSLL-IVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHNV 238

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 602665565  270 TSVGTFIASVIFMVITPMLNPVIYSLKNNEVRNAMKRV 307
Cdd:pfam13853 239 PPLLQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRM 276

Name

Accession

Description

Interval

E-value

7tmA_OR1A-like

cd15235

olfactory receptor subfamily 1A and related proteins, member of the class A family of ...

24-304

5.98e-147

Pssm-ID: 320363 [Multi-domain] Cd Length: 278 Bit Score: 414.31 E-value: 5.98e-147

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  24 EGPLFSLFLFMYLLTFLGNSLIILLILFDAHLCgLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLY 103
Cdd:cd15235    1 QPLLFLLFLAMYLLTLLGNLLIVLLIRSDPRLH-TPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMY 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 104 LLITLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIR 183
Cdd:cd15235   80 FFIAFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQ 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 184 ELLSLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQP 263
Cdd:cd15235  160 PLLKLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQP 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 602665565 264 SSpeRSTSVGTFIASVIFMVITPMLNPVIYSLKNNEVRNAM 304
Cdd:cd15235  240 SS--SYSADKDRVATVMYTVVTPMLNPFIYSLRNKDVKGAL 278

7tmA_OR1_7-like

cd15918

olfactory receptor families 1, 7, and related proteins, member of the class A family of ...

27-297

1.77e-125

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320584 [Multi-domain] Cd Length: 270 Bit Score: 359.62 E-value: 1.77e-125

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  27 LFSLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLI 106
Cdd:cd15918    3 LFGLFLGMYLVTVLGNLLIILAIGSDSHL-HTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 107 TLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIRELL 186
Cdd:cd15918   82 LFGDLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 187 SLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPSSP 266
Cdd:cd15918  162 KLSCSDTHLNELVILVLGGLVGLVPFLCILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPSS 241

                        250       260       270
                 ....*....|....*....|....*....|.
gi 602665565 267 erSTSVGTFIASVIFMVITPMLNPVIYSLKN 297
Cdd:cd15918  242 --HSASKDSVAAVMYTVVTPMLNPFIYSLRN 270

7tmA_OR

cd13954

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...

26-297

4.98e-113

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320092 [Multi-domain] Cd Length: 270 Bit Score: 327.90 E-value: 4.98e-113

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  26 PLFSLFLFMYLLTFLGNSLIILLILFDAHLCgLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLL 105
Cdd:cd13954    2 LLFVLFLLIYLLTLLGNLLIILLVRLDSRLH-TPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 106 ITLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIREL 185
Cdd:cd13954   81 FSLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 186 LSLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPSS 265
Cdd:cd13954  161 LKLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSS 240

                        250       260       270
                 ....*....|....*....|....*....|..
gi 602665565 266 pERSTSVGTFIaSVIFMVITPMLNPVIYSLKN 297
Cdd:cd13954  241 -SYSSDLDKVV-SVFYTVVTPMLNPIIYSLRN 270

7tmA_OR5-like

cd15230

olfactory receptor family 5 and related proteins, member of the class A family of ...

26-297

1.90e-108

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320358 Cd Length: 270 Bit Score: 316.37 E-value: 1.90e-108

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  26 PLFSLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLL 105
Cdd:cd15230    2 PLFVLFLLIYLITLVGNLGMIVLIRIDSRL-HTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 106 ITLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIREL 185
Cdd:cd15230   81 AVFGTTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 186 LSLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPSS 265
Cdd:cd15230  161 LKLSCSDTHINELVLFAFSGFIGLSTLLIILISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSS 240

                        250       260       270
                 ....*....|....*....|....*....|...
gi 602665565 266 perSTSVGTF-IASVIFMVITPMLNPVIYSLKN 297
Cdd:cd15230  241 ---SYSLDQDkVVSVFYTVVIPMLNPLIYSLRN 270

7tmA_OR10A-like

cd15225

olfactory receptor subfamily 10A and related proteins, member of the class A family of ...

25-304

1.27e-107

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320353 Cd Length: 277 Bit Score: 314.39 E-value: 1.27e-107

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  25 GPLFSLFLFMYLLTFLGNSLIILLILFDAHLCgLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYL 104
Cdd:cd15225    1 LLLFVVFLLIYLVTLLGNLLIILITKVDPALH-TPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 105 LITLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIRE 184
Cdd:cd15225   80 FLFLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPP 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 185 LLSLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPS 264
Cdd:cd15225  160 VLKLACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPK 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 602665565 265 SPErSTSVGTFIaSVIFMVITPMLNPVIYSLKNNEVRNAM 304
Cdd:cd15225  240 SSY-SPETDKLL-SLFYTVVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR5V1-like

cd15231

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...

27-304

8.27e-103

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320359 [Multi-domain] Cd Length: 277 Bit Score: 302.26 E-value: 8.27e-103

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  27 LFSLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLI 106
Cdd:cd15231    3 LFLIFLIIYLVTLLGNLLIITLVLLDSHL-HTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 107 TLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIRELL 186
Cdd:cd15231   82 SFVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 187 SLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPSSp 266
Cdd:cd15231  162 KLSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSS- 240

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 602665565 267 ERSTSVGTFIaSVIFMVITPMLNPVIYSLKNNEVRNAM 304
Cdd:cd15231  241 GYSLDKDTLI-SVLYSIVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR5D-like

cd15410

olfactory receptor subfamily 5D and related proteins, member of the class A family of ...

12-307

3.32e-101

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320532 Cd Length: 294 Bit Score: 298.80 E-value: 3.32e-101

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  12 FVLRGFSIQPQYEGPLFSLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNK 91
Cdd:cd15410    1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKL-HTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  92 TISYTECLLQLYLLITLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCG 171
Cdd:cd15410   80 AISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 172 SLEISHFFCDIRELLSLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAF 251
Cdd:cd15410  160 SNVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTILRIRSAEGRQKAFSTCASHLTAITI 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 602665565 252 YFGSIMGVYFQPSSperSTSVGTF-IASVIFMVITPMLNPVIYSLKNNEVRNAMKRV 307
Cdd:cd15410  240 FHGTILFMYCRPSS---SYSLDTDkVASVFYTVVIPMLNPLIYSLRNKDVKDALRKL 293

7tmA_OR7-like

cd15234

olfactory receptor family 7 and related proteins, member of the class A family of ...

26-304

1.10e-100

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320362 [Multi-domain] Cd Length: 277 Bit Score: 296.80 E-value: 1.10e-100

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  26 PLFSLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLL 105
Cdd:cd15234    2 LLFGLFLSMYLVTVLGNLLIILAVSSDSHL-HTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 106 ITLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIREL 185
Cdd:cd15234   81 LLFGGLDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 186 LSLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFqpSS 265
Cdd:cd15234  161 LKLACSDTLINNILIYLATVIFGGIPLSGIIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYI--SS 238

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 602665565 266 PERSTSVGTFIASVIFMVITPMLNPVIYSLKNNEVRNAM 304
Cdd:cd15234  239 AVTHSSRKTAVASVMYTVVTPMLNPFIYSLRNKDMKGAL 277

7tmA_OR5AP2-like

cd15943

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...

11-307

3.62e-100

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320609 [Multi-domain] Cd Length: 295 Bit Score: 296.20 E-value: 3.62e-100

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  11 DFVLRGFSIQPQYEGPLFSLFLFMYLLTFLGNSLIILLILFDAHLCGlPMYFFLIQLSLVDICFSSATTPKMLEILLSKN 90
Cdd:cd15943    1 EFILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHT-PMYFFLSHLSFLDLCYSSAITPKMLVNFLAEN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  91 KTISYTECLLQLYLLITLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFC 170
Cdd:cd15943   80 KTISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFC 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 171 GSLEISHFFCDIRELLSLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVA 250
Cdd:cd15943  160 GSNVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAILRIHSSEGRRKAFSTCASHLMAVT 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 602665565 251 FYFGSIMGVYFQPSSpeRSTSVGTFIASVIFMVITPMLNPVIYSLKNNEVRNAMKRV 307
Cdd:cd15943  240 IFYGTTLFMYLRPSS--SYSLDQDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRI 294

7tmA_OR8H-like

cd15411

olfactory receptor subfamily 8H and related proteins, member of the class A family of ...

26-306

1.04e-99

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320533 [Multi-domain] Cd Length: 279 Bit Score: 294.61 E-value: 1.04e-99

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  26 PLFSLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLL 105
Cdd:cd15411    2 PLFVLFLVIYVITVMGNLGMILLIRADSQL-HTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 106 ITLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIREL 185
Cdd:cd15411   81 IALATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 186 LSLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPSS 265
Cdd:cd15411  161 LKLSCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSS 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 602665565 266 perSTSVG-TFIASVIFMVITPMLNPVIYSLKNNEVRNAMKR 306
Cdd:cd15411  241 ---SYSLGqDKVASVFYTVVIPMLNPLIYSLRNKEVKNALRR 279

7tmA_OR8S1-like

cd15229

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...

26-304

3.47e-98

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320357 [Multi-domain] Cd Length: 277 Bit Score: 290.65 E-value: 3.47e-98

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  26 PLFSLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLL 105
Cdd:cd15229    2 FLFLVFLVIYLLTLLGNLLIMLVIRADSHL-HTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 106 ITLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIREL 185
Cdd:cd15229   81 FFFAGTEAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 186 LSLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPSS 265
Cdd:cd15229  161 LPLSCSDTFANKMVLLTSSVIFGLGSFLLTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPNS 240

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 602665565 266 peRSTSVGTFIASVIFMVITPMLNPVIYSLKNNEVRNAM 304
Cdd:cd15229  241 --ASSSVLDRVFSIQYSILTPMLNPIIYSLKNKEVKAAL 277

7tmA_OR5A1-like

cd15417

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...

27-306

2.06e-97

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320539 Cd Length: 279 Bit Score: 288.77 E-value: 2.06e-97

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  27 LFSLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLI 106
Cdd:cd15417    3 LFVLFLGIYLVTLLWNLGLIILIRMDSHL-HTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 107 TLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIRELL 186
Cdd:cd15417   82 GMGLTECFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 187 SLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPSSp 266
Cdd:cd15417  162 SLSCSDTFISQVVLFLVAVLFGVFSVLVVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSS- 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 602665565 267 ERSTSVGTfIASVIFMVITPMLNPVIYSLKNNEVRNAMKR 306
Cdd:cd15417  241 SHSQDQDK-VASVFYTVVIPMLNPLIYSLRNKEIKDALKR 279

7tmA_OR11A-like

cd15911

olfactory receptor subfamily 11A and related proteins, member of the class A family of ...

26-297

4.20e-97

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320577 Cd Length: 270 Bit Score: 287.46 E-value: 4.20e-97

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  26 PLFSLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLL 105
Cdd:cd15911    2 LLFLLFLVIYIVTMAGNILIIVLVVADRHL-HTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 106 ITLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIREL 185
Cdd:cd15911   81 GSLAATECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 186 LSLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPSS 265
Cdd:cd15911  161 LKLSCSDTSLVELVTFILSSIVTLPPFLLTLTSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPST 240

                        250       260       270
                 ....*....|....*....|....*....|..
gi 602665565 266 PERSTSVGTFiaSVIFMVITPMLNPVIYSLKN 297
Cdd:cd15911  241 NTSRDLNKVF--SLFYTVLTPLVNPLIYSLRN 270

7tmA_OR5AK3-like

cd15408

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...

12-301

2.15e-96

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320530 Cd Length: 287 Bit Score: 286.52 E-value: 2.15e-96

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  12 FVLRGFSIQPQYEGPLFSLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNK 91
Cdd:cd15408    1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRL-HTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  92 TISYTECLLQLYLLITLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCG 171
Cdd:cd15408   80 VISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 172 SLEISHFFCDIRELLSLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAF 251
Cdd:cd15408  160 SNVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATILRMRSAEGRHKAFSTCASHLTAVTL 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 602665565 252 YFGSIMGVYFQPSSPeRSTSVGTfIASVIFMVITPMLNPVIYSLKNNEVR 301
Cdd:cd15408  240 FYGSLAFMYLRPSSR-YSLDLDK-VASVFYTVVIPMLNPLIYSLRNKEVK 287

7tmA_OR9K2-like

cd15419

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...

27-306

2.15e-95

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320541 Cd Length: 279 Bit Score: 283.43 E-value: 2.15e-95

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  27 LFSLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLI 106
Cdd:cd15419    3 LFLLFLVIYMVTVLGNIGMIIIISTDSRL-HTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 107 TLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIRELL 186
Cdd:cd15419   82 LFGTTEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 187 SLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQP--- 263
Cdd:cd15419  162 KLSCSDTFINELVMFVLCGLIIVSTILVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPgav 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 602665565 264 SSPERSTsvgtfIASVIFMVITPMLNPVIYSLKNNEVRNAMKR 306
Cdd:cd15419  242 SSPEQSK-----VVSVFYTLVIPMLNPLIYSLRNKDVKEALKR 279

7tmA_OR1E-like

cd15236

olfactory receptor subfamily 1E and related proteins, member of the class A family of ...

25-304

4.97e-94

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320364 [Multi-domain] Cd Length: 277 Bit Score: 280.12 E-value: 4.97e-94

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  25 GPLFSLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYL 104
Cdd:cd15236    1 GVFFALFLAMYLTTVLGNLLIILLIRLDSHL-HTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 105 LITLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIRE 184
Cdd:cd15236   80 FIFFGCLDSFLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 185 LLSLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPS 264
Cdd:cd15236  160 LLKLSCSSTSLNELVIFTEGGLLFVLPLLLILGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPS 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 602665565 265 SpeRSTSVGTFIASVIFMVITPMLNPVIYSLKNNEVRNAM 304
Cdd:cd15236  240 S--NNSSDKDIVASVMYTVVTPMLNPFIYSLRNRDIKGAL 277

7tmA_OR14-like

cd15227

olfactory receptor family 14 and related proteins, member of the class A family of ...

28-297

1.67e-92

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320355 Cd Length: 270 Bit Score: 275.87 E-value: 1.67e-92

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  28 FSLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLIT 107
Cdd:cd15227    4 FVLFLLIYLAALTGNLLIITVVTLDHHL-HTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFIF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 108 LANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIRELLS 187
Cdd:cd15227   83 FAASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 188 LSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPSSpe 267
Cdd:cd15227  163 LSCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPS-- 240

                        250       260       270
                 ....*....|....*....|....*....|
gi 602665565 268 RSTSVGTFIASVIFMVITPMLNPVIYSLKN 297
Cdd:cd15227  241 DSPSLLDLLLSVFYSVVPPTLNPIIYSLRN 270

7tmA_OR8D-like

cd15406

olfactory receptor subfamily 8D and related proteins, member of the class A family of ...

16-307

1.40e-91

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320528 [Multi-domain] Cd Length: 290 Bit Score: 274.25 E-value: 1.40e-91

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  16 GFSIQPQYEGPLFSLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISY 95
Cdd:cd15406    1 GLTDQPELQLPLFLLFLGIYVVTVVGNLGMILLITLSSQL-HTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISY 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  96 TECLLQLYLLITLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEI 175
Cdd:cd15406   80 PECMTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVI 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 176 SHFFCDIRELLSLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGS 255
Cdd:cd15406  160 NHYFCDILPLLKLSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGS 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 602665565 256 IMGVYFQPSSperSTSVGT-FIASVIFMVITPMLNPVIYSLKNNEVRNAMKRV 307
Cdd:cd15406  240 IIFMYLKPSS---SSSMTQeKVSSVFYTTVIPMLNPLIYSLRNKDVKNALKKV 289

7tmA_OR5H-like

cd15409

olfactory receptor subfamily 5H and related proteins, member of the class A family of ...

26-306

4.66e-91

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320531 [Multi-domain] Cd Length: 279 Bit Score: 272.74 E-value: 4.66e-91

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  26 PLFSLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLL 105
Cdd:cd15409    2 PLFLVFLAIYLITLVGNLGLIALIWKDSHL-HTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 106 ITLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIREL 185
Cdd:cd15409   81 GFSATTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 186 LSLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPSS 265
Cdd:cd15409  161 LKISCTDPSINELVLFIFSGSIQVFTILTVLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSS 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 602665565 266 PERSTSvgTFIASVIFMVITPMLNPVIYSLKNNEVRNAMKR 306
Cdd:cd15409  241 LYALDQ--DMMDSLFYTIVIPLLNPFIYSLRNKEVIDALRK 279

7tmA_OR2T-like

cd15421

olfactory receptor subfamily 2T and related proteins, member of the class A family of ...

27-304

1.99e-90

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320543 Cd Length: 277 Bit Score: 270.96 E-value: 1.99e-90

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  27 LFSLFLFMYLLTFLGNSLIILLILFDAHLCgLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLI 106
Cdd:cd15421    3 LFSLILLIFLVALTGNALLILLIWLDSRLH-TPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 107 TLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIRELL 186
Cdd:cd15421   82 TLGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 187 SLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPSS- 265
Cdd:cd15421  162 KLSCADTSAYETVVYVSGVLFLLIPFSLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSy 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 602665565 266 --PERSTSVgtfiaSVIFMVITPMLNPVIYSLKNNEVRNAM 304
Cdd:cd15421  242 hsPEQDKVV-----SVFYTILTPMLNPLIYSLRNKEVLGAL 277

7tmA_OR13H-like

cd15431

olfactory receptor subfamily 13H and related proteins, member of the class A family of ...

26-297

4.41e-90

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320548 [Multi-domain] Cd Length: 269 Bit Score: 269.86 E-value: 4.41e-90

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  26 PLFSLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLL 105
Cdd:cd15431    2 ILFVLLLIVYLVTLLGNGLIILLIRVDSQL-HTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYIS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 106 ITLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHsFCGSLEISHFFCDIREL 185
Cdd:cd15431   81 LFLGITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVIPVLTMPLH-FCGPNVINHFFCEVQAL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 186 LSLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPSS 265
Cdd:cd15431  160 LKLACSDTSLNEILMFATSIFTLLLPFSFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQS 239

                        250       260       270
                 ....*....|....*....|....*....|..
gi 602665565 266 peRSTSVGTFIASVIFMVITPMLNPVIYSLKN 297
Cdd:cd15431  240 --KSSSDQDKIISVFYGVVTPMLNPLIYSLRN 269

7tmA_OR6C-like

cd15912

olfactory receptor subfamily 6C and related proteins, member of the class A family of ...

27-297

1.82e-89

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320578 Cd Length: 270 Bit Score: 268.20 E-value: 1.82e-89

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  27 LFSLFLFMYLLTFLGNSLIILLILFDAHLCgLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLI 106
Cdd:cd15912    3 LFLLLLLTYLLTLLGNLLIITITLVDHRLH-TPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 107 TLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIRELL 186
Cdd:cd15912   82 FLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 187 SLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPSsp 266
Cdd:cd15912  162 KLSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPS-- 239

                        250       260       270
                 ....*....|....*....|....*....|.
gi 602665565 267 ERSTSVGTFIASVIFMVITPMLNPVIYSLKN 297
Cdd:cd15912  240 QSSSLDLNKVVALLNTVVTPLLNPFIYTLRN 270

7tmA_OR5P-like

cd15416

olfactory receptor subfamily 5P and related proteins, member of the class A family of ...

26-306

7.72e-89

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320538 [Multi-domain] Cd Length: 279 Bit Score: 266.93 E-value: 7.72e-89

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  26 PLFSLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLL 105
Cdd:cd15416    2 ILFVLFLVIYSVTLLGNLSIILLIRISSQL-HTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 106 ITLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIREL 185
Cdd:cd15416   81 ATFGTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 186 LSLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPSS 265
Cdd:cd15416  161 LKLSCSDIRLAKILPSISSGIIILVTVLTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNS 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 602665565 266 peRSTSVGTFIASVIFMVITPMLNPVIYSLKNNEVRNAMKR 306
Cdd:cd15416  241 --SYSMDQNKVVSVFYMVVIPMLNPLIYSLRNKEVKGALKR 279

7tmA_OR8K-like

cd15413

olfactory receptor subfamily 8K and related proteins, member of the class A family of ...

26-306

7.97e-89

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320535 Cd Length: 279 Bit Score: 266.88 E-value: 7.97e-89

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  26 PLFSLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLL 105
Cdd:cd15413    2 PLFGLFLVIYLTTVMGNLGMIILTRLDSRL-QTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 106 ITLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIREL 185
Cdd:cd15413   81 LTFIISELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 186 LSLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPSS 265
Cdd:cd15413  161 LALSCSDTHEKELIILIFAGFNLISSLLIVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKS 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 602665565 266 perSTSVGT-FIASVIFMVITPMLNPVIYSLKNNEVRNAMKR 306
Cdd:cd15413  241 ---SHSLDTdKMASVFYTLVIPMLNPLIYSLRNKEVKDALKK 279

7tmA_OR2-like

cd15237

olfactory receptor family 2 and related proteins, member of the class A family of ...

26-297

5.17e-88

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320365 [Multi-domain] Cd Length: 270 Bit Score: 264.52 E-value: 5.17e-88

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  26 PLFSLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLL 105
Cdd:cd15237    2 LLFILFLLIYLLTLLGNGLIILLIWLDSRL-HTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 106 ITLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIREL 185
Cdd:cd15237   81 LALGVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 186 LSLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPSS 265
Cdd:cd15237  161 LKLACADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHS 240

                        250       260       270
                 ....*....|....*....|....*....|..
gi 602665565 266 PErSTSVGTFIaSVIFMVITPMLNPVIYSLKN 297
Cdd:cd15237  241 TH-SPDQDKMI-SVFYTIVTPMLNPLIYSLRN 270

7tmA_OR2F-like

cd15429

olfactory receptor subfamily 2F and related proteins, member of the class A family of ...

27-304

1.65e-85

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320546 [Multi-domain] Cd Length: 277 Bit Score: 258.49 E-value: 1.65e-85

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  27 LFSLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLI 106
Cdd:cd15429    3 LFVLFLVMYLLTLLGNFLIILLIRLDPRL-HTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 107 TLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIRELL 186
Cdd:cd15429   82 ALGGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 187 SLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPSSp 266
Cdd:cd15429  162 RLACVDTSLNEVAILVSSVVVLLTPCFLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRS- 240

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 602665565 267 eRSTSVGTFIASVIFMVITPMLNPVIYSLKNNEVRNAM 304
Cdd:cd15429  241 -GSSALQEKMISLFYAVVTPMLNPLIYSLRNKEVKGAL 277

7tmA_OR5M-like

cd15412

olfactory receptor subfamily 5M and related proteins, member of the class A family of ...

26-306

8.18e-84

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320534 Cd Length: 279 Bit Score: 254.25 E-value: 8.18e-84

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  26 PLFSLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLL 105
Cdd:cd15412    2 LLFVLFLVIYLITLLGNLGMILLIRLDSRL-HTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 106 ITLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIREL 185
Cdd:cd15412   81 IALVITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 186 LSLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPSS 265
Cdd:cd15412  161 IKLSCSDTYVKETAMFIVAGFNLSSSLLIILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPS 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 602665565 266 pERSTSVGTfIASVIFMVITPMLNPVIYSLKNNEVRNAMKR 306
Cdd:cd15412  241 -EESVEQSK-IVAVFYTFVSPMLNPLIYSLRNKDVKQALKK 279

7tmA_OR13-like

cd15232

olfactory receptor family 13 and related proteins, member of the class A family of ...

25-297

1.72e-83

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320360 [Multi-domain] Cd Length: 270 Bit Score: 252.95 E-value: 1.72e-83

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  25 GPLFSLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYL 104
Cdd:cd15232    1 VLLFWLFLFLYAAALTGNSLIILAISTSPKL-HTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 105 LITLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIRE 184
Cdd:cd15232   80 FTWSLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPP 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 185 LLSLSCSDVSIHQMIIFIegASVTLSPLVC--ILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQ 262
Cdd:cd15232  160 LLLLSCSDTSLNEIMAFV--ADVFFGVGNFllTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIR 237

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 602665565 263 PSS---PERSTSVgtfiaSVIFMVITPMLNPVIYSLKN 297
Cdd:cd15232  238 PSSsysPEKDKVV-----AVLYSVVTPTLNPLIYSLRN 270

7tmA_OR5J-like

cd15415

olfactory receptor subfamily 5J and related proteins, member of the class A family of ...

26-306

1.29e-82

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320537 [Multi-domain] Cd Length: 279 Bit Score: 251.18 E-value: 1.29e-82

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  26 PLFSLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLL 105
Cdd:cd15415    2 PLFMLFLLIYFITLLGNLGMIVLIRINPQL-HTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 106 ITLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIREL 185
Cdd:cd15415   81 AVFVTTEGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 186 LSLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPSS 265
Cdd:cd15415  161 LKLSCSDTHINELLLLTFSGVIAMSTLLTIIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSS 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 602665565 266 perSTSVGT-FIASVIFMVITPMLNPVIYSLKNNEVRNAMKR 306
Cdd:cd15415  241 ---QYSLEQeKVSAVFYTLVIPMLNPLIYSLRNKDVKDALKR 279

7tmA_OR5C1-like

cd15945

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...

12-306

1.67e-82

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320611 Cd Length: 292 Bit Score: 251.20 E-value: 1.67e-82

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  12 FVLRGFSIQPQYEGPLFSLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNK 91
Cdd:cd15945    1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQL-HTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  92 TISYTECLLQLYLLITLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCG 171
Cdd:cd15945   80 SIPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 172 SLEISHFFCDIRELLSLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAF 251
Cdd:cd15945  160 SNTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGL 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 602665565 252 YFGSIMGVYFQPSSperSTSVGT-FIASVIFMVITPMLNPVIYSLKNNEVRNAMKR 306
Cdd:cd15945  240 FYGTLLFMYLRPSS---SYSLDTdKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292

7tmA_OR2A-like

cd15420

olfactory receptor subfamily 2A and related proteins, member of the class A family of ...

27-304

2.56e-82

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320542 [Multi-domain] Cd Length: 277 Bit Score: 250.32 E-value: 2.56e-82

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  27 LFSLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLI 106
Cdd:cd15420    3 LFGLFSLLYIFTLLGNGLILGLIWLDSRL-HTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 107 TLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIRELL 186
Cdd:cd15420   82 ALAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 187 SLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPSSp 266
Cdd:cd15420  162 KLACADTWINEILIFAGCVFILLGPFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGS- 240

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 602665565 267 eRSTSVGTFIASVIFMVITPMLNPVIYSLKNNEVRNAM 304
Cdd:cd15420  241 -SNSAEQEKILSLFYSLFNPMLNPLIYSLRNKQVKGAL 277

7tmA_OR13-like

cd15430

olfactory receptor family 13 and related proteins, member of the class A family of ...

27-297

2.19e-81

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320547 [Multi-domain] Cd Length: 270 Bit Score: 247.67 E-value: 2.19e-81

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  27 LFSLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLI 106
Cdd:cd15430    3 LFVLCLIMYLVILLGNGVLIIITILDSHL-HTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 107 TLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIRELL 186
Cdd:cd15430   82 AMGSTECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAVL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 187 SLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPSSP 266
Cdd:cd15430  162 KLACVDISLNEIIMLVGNIIFLVIPLLLICISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKSK 241

                        250       260       270
                 ....*....|....*....|....*....|.
gi 602665565 267 ERSTSVGtfIASVIFMVITPMLNPVIYSLKN 297
Cdd:cd15430  242 NAQISDK--LITLFYGVVTPMLNPIIYSLRN 270

7tmA_OR5B-like

cd15407

olfactory receptor subfamily 5B and related proteins, member of the class A family of ...

26-306

2.76e-81

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320529 Cd Length: 279 Bit Score: 247.72 E-value: 2.76e-81

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  26 PLFSLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLL 105
Cdd:cd15407    2 PLFIIFTLIYLITLVGNLGMILLILLDSRL-HTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 106 ITLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIREL 185
Cdd:cd15407   81 VVFATVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 186 LSLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPSS 265
Cdd:cd15407  161 LALSCSDIHISEIVLFFLASFNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSS 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 602665565 266 perSTSVGT-FIASVIFMVITPMLNPVIYSLKNNEVRNAMKR 306
Cdd:cd15407  241 ---SHSMDTdKMASVFYTMVIPMLNPLVYSLRNKEVKSAFKK 279

7tmA_OR6B-like

cd15224

olfactory receptor subfamily 6B and related proteins, member of the class A family of ...

27-297

2.95e-81

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320352 Cd Length: 270 Bit Score: 247.20 E-value: 2.95e-81

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  27 LFSLFLFMYLLTFLGNSLIILLILFDAHLCgLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLI 106
Cdd:cd15224    3 LFLLFLIAYVLTLLENLLIILTIWLNSQLH-KPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 107 TLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIRELL 186
Cdd:cd15224   82 SLACTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 187 SLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPSsp 266
Cdd:cd15224  162 NLSCTDMSLAELVDFILALIILLVPLLVTVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPK-- 239

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 602665565 267 erstSVGTF----IASVIFMVITPMLNPVIYSLKN 297
Cdd:cd15224  240 ----AISSFdsnkLVSVLYTVVTPLLNPIIYCLRN 270

7tmA_OR5G-like

cd15414

olfactory receptor subfamily 5G and related proteins, member of the class A family of ...

26-310

8.28e-81

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320536 [Multi-domain] Cd Length: 285 Bit Score: 246.57 E-value: 8.28e-81

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  26 PLFSLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLL 105
Cdd:cd15414    2 PLFLLFLLVYLITLLGNLGMIILIQVDSRL-HTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 106 ITLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIREL 185
Cdd:cd15414   81 GLFVAAECFLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 186 LSLSCSDVSIHQMIIFI-EGASVTLSPLVcILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPS 264
Cdd:cd15414  161 LSLSCADTQINKWVLFImAGALGVLSGLI-ILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPS 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 602665565 265 SperSTSVGTF-IASVIFMVITPMLNPVIYSLKNNEVRNAMKRVCRK 310
Cdd:cd15414  240 S---SSSLDLDkVVSVFYTAVIPMLNPLIYSLRNKEVKDALRRTIRR 283

7tmA_OR10G-like

cd15916

olfactory receptor subfamily 10G and related proteins, member of the class A family of ...

26-304

7.69e-80

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320582 [Multi-domain] Cd Length: 276 Bit Score: 243.90 E-value: 7.69e-80

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  26 PLFSLFLFMYLLTFLGNSLIILLILFDAHLCgLPMYFFLIQLSLVDICFSSATTPKMLEILLSKN-KTISYTECLLQLYL 104
Cdd:cd15916    2 LLFLIFLIIYLLTVLGNLLILLTVWVDSHLH-RPMYIFLGHLSFLDMWLSTVTVPKMLAGFLEPGgKVISFGGCVAQLYF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 105 LITLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIRE 184
Cdd:cd15916   81 FHFLGSTECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 185 LLSLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPs 264
Cdd:cd15916  161 LLKLACADTTINELVIFASIGVVALGCFILILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRP- 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 602665565 265 speRSTSVGTFIASVIFMVITPMLNPVIYSLKNNEVRNAM 304
Cdd:cd15916  240 ---GSKEALDGVIAVFYTVVTPLLNPLIYTLRNKEVKTAL 276

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

27-297

1.75e-79

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 242.50 E-value: 1.75e-79

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  27 LFSLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLI 106
Cdd:cd15939    3 CFVVFLLIYLATVLGNLLIVVTIKASQTL-GSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 107 TLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIRELL 186
Cdd:cd15939   82 FFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 187 SLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNiLKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPSSp 266
Cdd:cd15939  162 KLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYS-LRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVT- 239

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 602665565 267 erstsvgTF----IASVIFMVITPMLNPVIYSLKN 297
Cdd:cd15939  240 -------TFpidkVVAVFYTIITPMLNPLIYTLRN 267

7tmA_OR2_unk

cd15424

olfactory receptor family 2, unknown subfamily, member of the class A family of ...

27-304

6.13e-79

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320544 [Multi-domain] Cd Length: 277 Bit Score: 241.56 E-value: 6.13e-79

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  27 LFSLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLI 106
Cdd:cd15424    3 LFVVILIIYLLTILGNLVIIILVQTDSRL-HTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIAL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 107 TLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIRELL 186
Cdd:cd15424   82 SLGSTECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 187 SLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPSSP 266
Cdd:cd15424  162 KLACADTHITEAIVFGAGVLILLVPLSVILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRSG 241

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 602665565 267 erSTSVGTFIASVIFMVITPMLNPVIYSLKNNEVRNAM 304
Cdd:cd15424  242 --STPDRDKQIAVFYIVITPLLNPIIYTLRNKDVHGAA 277

7tmA_OR2B-like

cd15947

olfactory receptor subfamily 2B and related proteins, member of the class A family of ...

26-297

1.25e-78

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320613 [Multi-domain] Cd Length: 270 Bit Score: 240.60 E-value: 1.25e-78

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  26 PLFSLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLL 105
Cdd:cd15947    2 PLFVVVLIFYLLTLLGNTAIILLSLLDPRL-HTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 106 ITLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIREL 185
Cdd:cd15947   81 LWLGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 186 LSLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPSS 265
Cdd:cd15947  161 IKLACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPS 240

                        250       260       270
                 ....*....|....*....|....*....|..
gi 602665565 266 PeRSTSVGTFIaSVIFMVITPMLNPVIYSLKN 297
Cdd:cd15947  241 S-YSQDQGKFI-SLFYTVVTPTLNPLIYTLRN 270

7tmA_OR5AR1-like

cd15944

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...

12-307

2.60e-78

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320610 [Multi-domain] Cd Length: 294 Bit Score: 240.46 E-value: 2.60e-78

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  12 FVLRGFSIQPQYEGPLFSLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNK 91
Cdd:cd15944    1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQL-HTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  92 TISYTECLLQLYLLITLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCG 171
Cdd:cd15944   80 VISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 172 SLEISHFFCDIRELLSLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAF 251
Cdd:cd15944  160 SNIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAILRMRSAEGRRKAFSTCASHFTGVTL 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 252 YFGSIMGVYFQPsspersTSVGTF----IASVIFMVITPMLNPVIYSLKNNEVRNAMKRV 307
Cdd:cd15944  240 FYGTVIFMYLRP------TSVYSLdqdkWASVFYTVVIPMLNPLIYSLRNKDVKEAFKKL 293

7tmA_OR12D-like

cd15915

olfactory receptor subfamily 12D and related proteins, member of the class A family of ...

27-297

7.80e-78

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320581 [Multi-domain] Cd Length: 271 Bit Score: 238.74 E-value: 7.80e-78

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  27 LFSLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLI 106
Cdd:cd15915    3 LFVLFLLLYLASLLGNGAILAVVIAEPRL-HSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 107 TLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIRELL 186
Cdd:cd15915   82 FLGSSEAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 187 SLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIP-NAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPSS 265
Cdd:cd15915  162 KLACGDTSLNLWLLNIVTGSIALGTFILTLLSYIYIISFLLLKVrSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPSS 241

                        250       260       270
                 ....*....|....*....|....*....|..
gi 602665565 266 peRSTSVGTFIASVIFMVITPMLNPVIYSLKN 297
Cdd:cd15915  242 --GDSLEQDRIVALLYTVVTPVLNPLIYTLRN 271

7tmA_OR6N-like

cd15914

olfactory receptor OR6N and related proteins, member of the class A family of ...

27-297

1.84e-76

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320580 [Multi-domain] Cd Length: 270 Bit Score: 234.96 E-value: 1.84e-76

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  27 LFSLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLI 106
Cdd:cd15914    3 LFILLLLIYLFIITGNLLIFTVVRLDTHL-HTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 107 TLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIRELL 186
Cdd:cd15914   82 SLGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 187 SLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPS-- 264
Cdd:cd15914  162 SLACTDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSks 241

                        250       260       270
                 ....*....|....*....|....*....|....
gi 602665565 265 -SPERSTSVGtfiasVIFMVITPMLNPVIYSLKN 297
Cdd:cd15914  242 ySLDYDRAIA-----VVYAVLTPFFNPIIYSLRN 270

7tmA_OR10D-like

cd15228

olfactory receptor subfamily 10D and related proteins, member of the class A family of ...

27-304

2.11e-76

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320356 [Multi-domain] Cd Length: 275 Bit Score: 235.02 E-value: 2.11e-76

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  27 LFSLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLI 106
Cdd:cd15228    3 LFVLFLAFYLCTLLGNLLILSAILSDPRL-HTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 107 TLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIRELL 186
Cdd:cd15228   82 FLGSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 187 SLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPS-S 265
Cdd:cd15228  162 KLACADTSIAETVSFTNVGLVPLTCFLLILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTpS 241

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 602665565 266 PERSTSVGTFIAsvifmVITPMLNPVIYSLKNNEVRNAM 304
Cdd:cd15228  242 PVLVTPVQIFNN-----VVTPMLNPLIYTLRNKEVKAAL 275

7tmA_OR9G-like

cd15418

olfactory receptor subfamily 9G and related proteins, member of the class A family of ...

27-307

1.17e-73

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320540 [Multi-domain] Cd Length: 281 Bit Score: 228.13 E-value: 1.17e-73

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  27 LFSLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLI 106
Cdd:cd15418    4 LFVVFLLSYILTLVGNLTLIALICLDSRL-HTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFFSA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 107 TLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIRELL 186
Cdd:cd15418   83 GLAYSECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPPLV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 187 SLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPSS- 265
Cdd:cd15418  163 KLACDDTRVYELILYFILGFNVIAPTALILASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPSSs 242

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 602665565 266 --PERSTsvgtfIASVIFMVITPMLNPVIYSLKNNEVRNAMKRV 307
Cdd:cd15418  243 htPDRDK-----VVALFYTVVNPLLNPLIYSLRNKDVKEALKKL 281

7tmA_OR10S1-like

cd15941

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...

27-304

1.54e-73

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320607 [Multi-domain] Cd Length: 277 Bit Score: 227.81 E-value: 1.54e-73

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  27 LFSLFLFMYLLTFLGNSLIILLILFDAHLCGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKN-KTISYTECLLQLYLL 105
Cdd:cd15941    3 FFLLFLLIYLLTVLGNLLILLTIGSDPHLHGLPMYHFLGHLSFLDACLSSVTVPKVLAGLLTLSgRTISFEGCVVQLYAF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 106 ITLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIREL 185
Cdd:cd15941   83 HFLASTECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPPV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 186 LSLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPSS 265
Cdd:cd15941  163 LKLACADTTINELVILANIGIVAAGCFLLIVISYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPSS 242

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 602665565 266 PERSTSvgtfIASVIFMVITPMLNPVIYSLKNNEVRNAM 304
Cdd:cd15941  243 SQAGAG----APAVFYTIVTPMLNPFIYTLRNKEVKRAL 277

7tmA_OR8B-like

cd15405

olfactory receptor subfamily 8B and related proteins, member of the class A family of ...

26-304

1.00e-72

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320527 [Multi-domain] Cd Length: 277 Bit Score: 225.76 E-value: 1.00e-72

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  26 PLFSLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLL 105
Cdd:cd15405    2 PLFFLFLGIYVVTVVGNLGLITLICLNSHL-HTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 106 ITLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIREL 185
Cdd:cd15405   81 CFFVISECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 186 LSLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPSS 265
Cdd:cd15405  161 LQLSCTSTYVNELVVFVVVGINIIVPSVTIFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSS 240

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 602665565 266 PErSTSVGTFiASVIFMVITPMLNPVIYSLKNNEVRNAM 304
Cdd:cd15405  241 VG-SVNQGKV-SSVFYTNVVPMLNPLIYSLRNKDVKLAL 277

7tmA_OR11G-like

cd15913

olfactory receptor OR11G and related proteins, member of the class A family of ...

27-297

2.66e-72

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320579 Cd Length: 270 Bit Score: 224.50 E-value: 2.66e-72

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  27 LFSLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLI 106
Cdd:cd15913    3 LFSFFSVIYILTLLGNGAIICAVWWDRRL-HTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 107 TLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIRELL 186
Cdd:cd15913   82 SLGTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 187 SLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPSSp 266
Cdd:cd15913  162 ALSCVPAPGTELICYTLSSLIIFGTFLFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGS- 240

                        250       260       270
                 ....*....|....*....|....*....|.
gi 602665565 267 eRSTSVGTFIASVIFMVITPMLNPVIYSLKN 297
Cdd:cd15913  241 -GNSTGMQKIVTLFYSVVTPLLNPLIYSLRN 270

7tmA_OR4D-like

cd15936

olfactory receptor 4D and related proteins, member of the class A family of ...

26-297

1.10e-71

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320602 [Multi-domain] Cd Length: 267 Bit Score: 222.59 E-value: 1.10e-71

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  26 PLFSLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLL 105
Cdd:cd15936    2 FLFLVFLLVYLTTWLGNLLIIITVISDPHL-HTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 106 ITLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIREL 185
Cdd:cd15936   81 HFTGGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 186 LSLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNIlKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVY---FQ 262
Cdd:cd15936  161 IKLACTDTFLLELLMVSNSGLVTLLIFFILLISYTVILVKI-RTHVTEGKRKALSTCASQITVVTLIFVPCIYIYarpFQ 239

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 602665565 263 PSSPERstsvgtfIASVIFMVITPMLNPVIYSLKN 297
Cdd:cd15936  240 TFPMDK-------AVSVLYTVITPMLNPMIYTLRN 267

7tmA_OR1330-like

cd15946

olfactory receptor 1330 and related proteins, member of the class A family of ...

27-297

1.64e-71

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320612 Cd Length: 270 Bit Score: 222.35 E-value: 1.64e-71

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  27 LFSLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLI 106
Cdd:cd15946    3 LFAVFLLIYLSILLGNGLIITLICLDSRL-HTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 107 TLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIRELL 186
Cdd:cd15946   82 ALGITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 187 SLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQP--- 263
Cdd:cd15946  162 KLACADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPgsn 241

                        250       260       270
                 ....*....|....*....|....*....|....
gi 602665565 264 SSPERSTSVGTFiasviFMVITPMLNPVIYSLKN 297
Cdd:cd15946  242 YSPERDKKISLF-----YNVFTALLNPVIYSLRN 270

7tmA_OR2D-like

cd15428

olfactory receptor subfamily 2D and related proteins, member of the class A family of ...

27-304

5.63e-71

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320545 [Multi-domain] Cd Length: 277 Bit Score: 221.20 E-value: 5.63e-71

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  27 LFSLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLI 106
Cdd:cd15428    3 LFILFLIIYLMTVLGNLLLVLLVIVDSHL-HTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 107 TLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIRELL 186
Cdd:cd15428   82 SFGITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 187 SLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPSSp 266
Cdd:cd15428  162 KLASTDTHQAEMAMFIMCVFTLVLPVLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPKS- 240

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 602665565 267 eRSTSVGTFIASVIFMVITPMLNPVIYSLKNNEVRNAM 304
Cdd:cd15428  241 -STSKEYDKMISVFYIIVTPMLNPLIYSLRNKEVKHAL 277

7tmA_OR4-like

cd15226

olfactory receptor family 4 and related proteins, member of the class A family of ...

27-297

7.15e-71

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320354 [Multi-domain] Cd Length: 267 Bit Score: 220.54 E-value: 7.15e-71

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  27 LFSLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLI 106
Cdd:cd15226    3 LFVFFSLFYVATVLGNLLIVVTVTSDPHL-HSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 107 TLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIRELL 186
Cdd:cd15226   82 FFGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 187 SLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPnAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPSSp 266
Cdd:cd15226  162 KLACTDTYVLELMVVANSGLISLVCFLLLLISYIVILVTVRKHS-SGGSSKALSTCSAHITVVVLFFGPCIFIYVWPFS- 239

                        250       260       270
                 ....*....|....*....|....*....|.
gi 602665565 267 erSTSVGTFIAsVIFMVITPMLNPVIYSLKN 297
Cdd:cd15226  240 --TFPVDKFLA-VFYTVITPLLNPIIYTLRN 267

7tmA_OR4E-like

cd15940

olfactory receptor 4E and related proteins, member of the class A family of ...

27-297

1.08e-70

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320606 [Multi-domain] Cd Length: 267 Bit Score: 220.39 E-value: 1.08e-70

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  27 LFSLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLI 106
Cdd:cd15940    3 FFMLFLVLYLLTLSGNILIMITIVMDPRL-HTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 107 TLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIRELL 186
Cdd:cd15940   82 LFACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPVI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 187 SLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIpNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPSSp 266
Cdd:cd15940  162 KLACTDTYLIDILIVSNSGLISLVCFVALLGSYIVILVSLRKR-STEGRRKALSTCASHLTVVTLFFGPCIFIYTRPST- 239

                        250       260       270
                 ....*....|....*....|....*....|.
gi 602665565 267 erSTSVGTFIaSVIFMVITPMLNPVIYSLKN 297
Cdd:cd15940  240 --SFSEDKVV-SVFYTVVTPLLNPIIYTLRN 267

7tmA_OR2B2-like

cd15432

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...

26-304

1.63e-70

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320549 [Multi-domain] Cd Length: 277 Bit Score: 220.04 E-value: 1.63e-70

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  26 PLFSLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLL 105
Cdd:cd15432    2 VLFVVFLIFYILTLLGNLAIILVSRLDPQL-HTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 106 ITLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIREL 185
Cdd:cd15432   81 LGLGSTECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 186 LSLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPSS 265
Cdd:cd15432  161 LKLSCVDTTANEAELFVISVLLLLIPLGLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPS 240

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 602665565 266 PerSTSVGTFIASVIFMVITPMLNPVIYSLKNNEVRNAM 304
Cdd:cd15432  241 N--SSHDRGKMVALFYGIITPMLNPLIYTLRNKDVKEAL 277

7tmA_OR2W-like

cd15434

olfactory receptor subfamily 2W and related proteins, member of the class A family of ...

27-304

3.41e-70

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320551 [Multi-domain] Cd Length: 277 Bit Score: 219.17 E-value: 3.41e-70

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  27 LFSLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLI 106
Cdd:cd15434    3 LSVVVLIFYLLTLVGNTTIILVSCLDSRL-HTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIAL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 107 TLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIRELL 186
Cdd:cd15434   82 GLGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPALI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 187 SLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPsSP 266
Cdd:cd15434  162 KLACVDTTAYEATIFALGVFILLFPLSLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQP-KN 240

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 602665565 267 ERSTSVGTFIAsVIFMVITPMLNPVIYSLKNNEVRNAM 304
Cdd:cd15434  241 SVSQDQGKFLT-LFYTIVTPSLNPLIYTLRNKDVKGAL 277

7tmA_OR3A-like

cd15233

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...

27-304

8.54e-68

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320361 [Multi-domain] Cd Length: 277 Bit Score: 213.12 E-value: 8.54e-68

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  27 LFSLFLFMYLLTFLGNSLIILLILFDAHLCGlPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLI 106
Cdd:cd15233    3 LFVTFLLAYIVTIGGNLSILAAILLEPKLHT-PMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 107 TLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIRELL 186
Cdd:cd15233   82 LLAGADCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLF 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 187 SLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPSSP 266
Cdd:cd15233  162 QLSCSSTHLNELLLFVFAFFMALAPCVLIVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGSV 241

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 602665565 267 ErsTSVGTFIASVIFMVITPMLNPVIYSLKNNEVRNAM 304
Cdd:cd15233  242 Y--SSDKDKVIGILNTVLSPMLNPLIYSLRNKDVKGAL 277

7tmA_OR10G6-like

cd15942

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...

26-304

3.15e-67

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320608 Cd Length: 275 Bit Score: 211.52 E-value: 3.15e-67

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  26 PLFSLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLL 105
Cdd:cd15942    2 PLFLFFLVVYLLTLSGNSLIILVVISDLQL-HKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 106 ITLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIREL 185
Cdd:cd15942   81 HFLGCAECFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAM 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 186 LSLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPSS 265
Cdd:cd15942  161 LKLACADTAFNELVTFIDIGLVAMTCFLLILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGS 240

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 602665565 266 PERSTSVgtfiASVIFMVITPMLNPVIYSLKNNEVRNAM 304
Cdd:cd15942  241 QDPLDGV----VAVFYTTVTPLLNPVIYTLRNKEMKDAL 275

7tmA_OR4Q3-like

cd15935

olfactory receptor 4Q3 and related proteins, member of the class A family of ...

27-297

8.81e-61

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320601 [Multi-domain] Cd Length: 268 Bit Score: 194.98 E-value: 8.81e-61

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  27 LFSLFLFMYLLTFLGNSLIILLILFDAHLCGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLI 106
Cdd:cd15935    3 LFVLVLACYAAILLGNLLIVVTVHADPHLLQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFLH 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 107 TLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIRELL 186
Cdd:cd15935   83 FLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQVI 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 187 SLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNiLKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPSSP 266
Cdd:cd15935  163 KLACMDTYVVEVLMVANSGLLSLVCFLVLLVSYGIILTT-LRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPFSS 241

                        250       260       270
                 ....*....|....*....|....*....|.
gi 602665565 267 ERSTSVgtfiASVIFMVITPMLNPVIYSLKN 297
Cdd:cd15935  242 SSVDKV----ASVFYTLITPALNPLIYTLRN 268

7tmA_OR4Q2-like

cd15938

olfactory receptor 4Q2 and related proteins, member of the class A family of ...

27-297

9.90e-61

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320604 [Multi-domain] Cd Length: 265 Bit Score: 194.71 E-value: 9.90e-61

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  27 LFSLFLFMYLLTFLGNSLIILLILFDAHLCGlPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLI 106
Cdd:cd15938    3 LFALFLLAYTMVLVGNLLIMVTVRSDPKLSS-PMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 107 TLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIRELL 186
Cdd:cd15938   82 FVGAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 187 SLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILsniLKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPSSP 266
Cdd:cd15938  162 KLACTDTCVTELLMVSNSGLISTVCFVVLVTSYTTIL---VTIRSTEGRRKALSTCASHLMVVTLFFGPCIFIYARPFST 238

                        250       260       270
                 ....*....|....*....|....*....|.
gi 602665565 267 ERSTSvgtfIASVIFMVITPMLNPVIYSLKN 297
Cdd:cd15938  239 FPVDK----HVSVLYNVITPMLNPLIYTLRN 265

7tmA_OR2Y-like

cd15433

olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...

27-304

1.02e-58

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320550 [Multi-domain] Cd Length: 277 Bit Score: 190.00 E-value: 1.02e-58

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  27 LFSLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLI 106
Cdd:cd15433    3 LFVVVLIFYLLTLVGNTIIILLSVRDLRL-HTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 107 TLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIRELL 186
Cdd:cd15433   82 ALGSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVFL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 187 SLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPSSp 266
Cdd:cd15433  162 KLACGDDETTEVQMFVARVVILLLPAALILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIH- 240

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 602665565 267 ERSTSVGTFIaSVIFMVITPMLNPVIYSLKNNEVRNAM 304
Cdd:cd15433  241 RYSQAHGKFV-SLFYTVMTPALNPLIYTLRNKDVKGAL 277

7tmA_OR4N-like

cd15937

olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...

27-297

6.48e-57

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320603 Cd Length: 267 Bit Score: 184.94 E-value: 6.48e-57

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  27 LFSLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLI 106
Cdd:cd15937    3 LFVLFLLFYLIILPGNILIILTIQGDPQL-GSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 107 TLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIRELL 186
Cdd:cd15937   82 FLGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQVI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 187 SLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNiLKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPSSP 266
Cdd:cd15937  162 KLACTNTYTVELLMFSNSGLVILLCFLLLLISYAFLLAK-LRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARPFRS 240

                        250       260       270
                 ....*....|....*....|....*....|.
gi 602665565 267 ERSTSVGTFIASVIFmvitPMLNPVIYSLKN 297
Cdd:cd15937  241 FPMDKVVAVFHTVIF----PLLNPMIYTLRN 267

7tmA_OR56-like

cd15223

olfactory receptor family 56 and related proteins, member of the class A family of ...

27-304

3.73e-54

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320351 [Multi-domain] Cd Length: 279 Bit Score: 178.25 E-value: 3.73e-54

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  27 LFSLFLFMYLLTFLGNSLIILLILFDAHLCGlPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLI 106
Cdd:cd15223    3 LSLPFLLLYLVALVANSLLLLIIKLERSLHQ-PMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 107 TLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIRELL 186
Cdd:cd15223   82 FFTAMESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 187 SLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPS-S 265
Cdd:cd15223  162 SLACGDTTINSIYGLAVAWLIVGSDIILIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSLTYRfG 241

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 602665565 266 PERSTSVGTFIaSVIFMVITPMLNPVIYSLKNNEVRNAM 304
Cdd:cd15223  242 KTIPPDVHVLL-SVLYILIPPALNPIIYGVRTKEIRQGF 279

7tmA_OR51_52-like

cd15917

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...

31-300

3.50e-49

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341351 Cd Length: 275 Bit Score: 165.15 E-value: 3.50e-49

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  31 FLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLITLAN 110
Cdd:cd15917    7 FCAMYLVALLGNITILFVIKIESSL-HEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHSFTA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 111 VDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIRELLSLSC 190
Cdd:cd15917   86 MESGVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAVVKLAC 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 191 SDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPSSPERST 270
Cdd:cd15917  166 GDTRVNSIYGLFVALLIVGFDLLFIALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLTHRFGHHVP 245

                        250       260       270
                 ....*....|....*....|....*....|
gi 602665565 271 SVGTFIASVIFMVITPMLNPVIYSLKNNEV 300
Cdd:cd15917  246 PHVHILLANLYLLLPPMLNPIVYGVRTKQI 275

7tmA_OR52I-like

cd15950

olfactory receptor subfamily 52I and related proteins, member of the class A family of ...

30-300

5.73e-47

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320616 Cd Length: 275 Bit Score: 159.50 E-value: 5.73e-47

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  30 LFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLITLA 109
Cdd:cd15950    6 PFCSMYVIALLGNGTILLVIKLDPSL-HEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFT 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 110 NVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIRELLSLS 189
Cdd:cd15950   85 AVESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAVVKLA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 190 CSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVA-FYFGSIMGVYFQPSSPER 268
Cdd:cd15950  165 CADPRPSSLYSITGSTLVVGTDSAFIAVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILlFYIPGLLSIYTQRFGQGV 244

                        250       260       270
                 ....*....|....*....|....*....|..
gi 602665565 269 STSVGTFIASViFMVITPMLNPVIYSLKNNEV 300
Cdd:cd15950  245 PPHTQVLLADL-YLLVPPMLNPIIYGMRTKQI 275

7tmA_OR51-like

cd15222

olfactory receptor family 51 and related proteins, member of the class A family of ...

31-300

2.95e-44

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320350 Cd Length: 275 Bit Score: 152.27 E-value: 2.95e-44

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  31 FLFMYLLTFLGNSLIILLILFDAHLCGlPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLITLAN 110
Cdd:cd15222    7 FCLLYLVALLGNSTILFVIKTEPSLHE-PMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHTFSF 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 111 VDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSwLLPCLHSLLHTLLMSQH-SFCGSLEISHFFCDIRELLSLS 189
Cdd:cd15222   86 MESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAI-VLRSVLLLLPLPFLLKRlPFCHSNVLSHSYCLHQDVMKLA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 190 CSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGV-----YFQPS 264
Cdd:cd15222  165 CSDTRVNSIYGLFVVLSTMGLDSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPMIGLsmvhrFGKHA 244

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 602665565 265 SPerstSVGTFIASVIFMViTPMLNPVIYSLKNNEV 300
Cdd:cd15222  245 SP----LVHVLMANVYLLV-PPVLNPIIYSVKTKQI 275

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

31-307

2.27e-42

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 147.65 E-value: 2.27e-42

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565   31 FLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLITLAN 110
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSL-HQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  111 VDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIRELLSLSC 190
Cdd:pfam13853  80 MESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSC 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  191 SDVSIHQMI-IFIEGASVTLSPLVcILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPSSPERS 269
Cdd:pfam13853 160 ADIKVNNIYgLFVVTSTFGIDSLL-IVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHNV 238

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 602665565  270 TSVGTFIASVIFMVITPMLNPVIYSLKNNEVRNAMKRV 307
Cdd:pfam13853 239 PPLLQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRM 276

7tmA_OR52R_52L-like

cd15951

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...

31-300

4.11e-41

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320617 Cd Length: 275 Bit Score: 144.03 E-value: 4.11e-41

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  31 FLFMYLLTFLGNSLIILLILFDAHLCGlPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLITLAN 110
Cdd:cd15951    7 FCIMYAVALLGNFTILFIVKTEPSLHE-PMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFST 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 111 VDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIRELLSLSC 190
Cdd:cd15951   86 MESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVVKLAC 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 191 SDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILS-VAFY----FGSIMGVYFQPSS 265
Cdd:cd15951  166 ADTRVSRAYGLSVAFLVGGLDVIFIAVSYIQILRAVFKLPSKEARLKTFGTCGSHICViLVFYipalFSFLTHRFGHNVP 245

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 602665565 266 PErstsVGTFIASvIFMVITPMLNPVIYSLKNNEV 300
Cdd:cd15951  246 PH----VHILIAN-VYLLVPPMLNPIIYGVRTKQI 275

7tmA_OR52E-like

cd15952

olfactory receptor subfamily 52E and related proteins, member of the class A family of ...

31-300

5.16e-41

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320618 Cd Length: 274 Bit Score: 143.67 E-value: 5.16e-41

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  31 FLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLITLAN 110
Cdd:cd15952    7 FCAVYLIALLGNCTILFVIKTEQSL-HQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFTG 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 111 VDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIRELLSLSC 190
Cdd:cd15952   86 MESAVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIAKLAC 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 191 SDVSIHqmIIFIEGA-SVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHI-LSVAFY---FGSIMGVYFQPSS 265
Cdd:cd15952  166 ASIRIN--IIYGLFAiSVLVLDVILIALSYVLILRAVFRLPSHDARLKALSTCGSHVcVILAFYtpaLFSFLTHRFGHNI 243

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 602665565 266 PErstSVGTFIASvIFMVITPMLNPVIYSLKNNEV 300
Cdd:cd15952  244 PR---YIHILLAN-LYVVLPPMLNPVIYGVRTKQI 274

7tmA_OR52B-like

cd15221

olfactory receptor subfamily 52B and related proteins, member of the class A family of ...

31-300

7.11e-41

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320349 Cd Length: 275 Bit Score: 143.58 E-value: 7.11e-41

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  31 FLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLITLAN 110
Cdd:cd15221    7 FCSMYIVALLGNSLLLFVIVTERSL-HEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHFVFV 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 111 VDGFLLGSMAYDRYVAICFPLNYVAIMTR----KRCLELVAGSW--LLPClhsllhTLLMSQHSFCGSLEISHFFCDIRE 184
Cdd:cd15221   86 TESAILLAMAFDRYVAICYPLRYTTILTHsvigKIGVAAVARSFciVFPF------VFLLKRLPYCGHNVIPHTYCEHMG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 185 LLSLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVA-FYFGSIMGVYFQP 263
Cdd:cd15221  160 IARLACADITVNIWYGLTVALLTVGLDVVLIAVSYALILRAVFRLPSKDARLKALSTCGSHVCVILmFYTPAFFSFLTHR 239

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 602665565 264 SSPERSTSVGTFIASViFMVITPMLNPVIYSLKNNEV 300
Cdd:cd15221  240 FGRHIPRHVHILLANL-YVLVPPMLNPIVYGVKTKQI 275

7tmA_OR52P-like

cd15953

olfactory receptor subfamily 52P and related proteins, member of the class A family of ...

31-300

1.29e-38

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341354 Cd Length: 275 Bit Score: 137.78 E-value: 1.29e-38

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  31 FLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLITLAN 110
Cdd:cd15953    7 FCLMYIVTLLGNCTILFVVGKEQSL-HKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLSI 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 111 VDGFLLGSMAYDRYVAICFPLNYVAIMTRKR-----CLELVAGSWL-LPClhsllhTLLMSQHSFCGSLEISHFFCDIRE 184
Cdd:cd15953   86 MESAVLVAMAFDRYVAICNPLRYATILTNSRiaklgLVGLIRGVLLiLPL------PLLLSRLPFCANRIIPHTYCEHMA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 185 LLSLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSV-AFY----FGSIMGV 259
Cdd:cd15953  160 VVKLACGDTTINRIYGLVVALLVVGLDLLLIALSYALIIRAVLRLSSKKARQKALNTCTAHICVIlMSYtpalFSFLTHR 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 602665565 260 YFQPSSPerstSVGTFIASvIFMVITPMLNPVIYSLKNNEV 300
Cdd:cd15953  240 FGQGIAP----HIHIILAN-LYLLVPPMLNPIIYGVKTKEI 275

7tmA_OR52K-like

cd15948

olfactory receptor subfamily 52K and related proteins, member of the class A family of ...

31-301

1.13e-35

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320614 [Multi-domain] Cd Length: 277 Bit Score: 130.02 E-value: 1.13e-35

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  31 FLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLITLAN 110
Cdd:cd15948    8 FCSAFTVALLGNCTLLYVIKTEPSL-HEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFSI 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 111 VDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIRELLSLSC 190
Cdd:cd15948   87 MESAVLLAMAFDRYVAICNPLRYATILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRSHVIAHCYCEHMAVVKLAC 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 191 SDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSV-AFYFGSIMGVYFQPSSPERS 269
Cdd:cd15948  167 GDTRFNNIYGIAVALFIVGLDLMFIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAIlVFYTPVVLSSTMHRFARHVA 246

                        250       260       270
                 ....*....|....*....|....*....|..
gi 602665565 270 TSVGTFIASvIFMVITPMLNPVIYSLKNNEVR 301
Cdd:cd15948  247 PHVHILLAN-FYLLFPPMMNPIVYGVKTKQIR 277

7tmA_OR52M-like

cd15949

olfactory receptor subfamily 52M and related proteins, member of the class A family of ...

31-301

7.66e-35

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320615 Cd Length: 292 Bit Score: 127.97 E-value: 7.66e-35

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  31 FLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLITLAN 110
Cdd:cd15949   23 FCSMYLIAVLGNCTILFIIKSEPSL-HQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSSNEIPLHACLLQMFLIHSFSA 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 111 VDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIRELLSLSC 190
Cdd:cd15949  102 IESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWYRTNIIAHSYCEHMAVVGLAC 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 191 SDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSV-AFYF----GSIMGVYFQPSS 265
Cdd:cd15949  182 GDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVVQRLATSEARLKTFGTCVSHVCAIlAFYVpiavSSLIHRFGQNVP 261

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 602665565 266 PERSTSVGTFiasviFMVITPMLNPVIYSLKNNEVR 301
Cdd:cd15949  262 PPTHILLANF-----YLLIPPMLNPIVYGVRTKQIQ 292

7tmA_OR52W-like

cd15956

olfactory receptor subfamily 52W and related proteins, member of the class A family of ...

31-300

9.82e-34

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320622 [Multi-domain] Cd Length: 275 Bit Score: 124.98 E-value: 9.82e-34

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  31 FLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLITLAN 110
Cdd:cd15956    7 FCFIYVLSLLGNGVLLSVVWKEHRL-HQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHAFSA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 111 VDGFLLGSMAYDRYVAICFPLNYVAIMTrkrcLELVAGSWLLPCLHSLLHT----LLMSQHSFCGSLEISHFFCDIRELL 186
Cdd:cd15956   86 MESGVLVAMALDRFVAICNPLHYATILT----LEVVAKAGLLLALRGVAIVipfpLLVCRLSFCASHTIAHTYCEHMAVV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 187 SLSCSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFG----SIMGVYFQ 262
Cdd:cd15956  162 KLACGATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYIpgllSVLMHRFG 241

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 602665565 263 PSSPerstSVGTFIASVIFMVITPMLNPVIYSLKNNEV 300
Cdd:cd15956  242 HSVP----SAAHVLLSNLYLLLPPALNPIVYGIRTKQI 275

7tmA_OR52N-like

cd15954

olfactory receptor subfamily 52N and related proteins, member of the class A family of ...

31-300

6.70e-30

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320620 Cd Length: 276 Bit Score: 114.54 E-value: 6.70e-30

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  31 FLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLITLAN 110
Cdd:cd15954    7 FCFMYIIAMVGNCGLLYLIWIEEAL-HRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFTG 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 111 VDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIRELLSLSC 190
Cdd:cd15954   86 MESGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVVKLAC 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 191 SDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILS-VAFYFGSIMGVYFQPSSPERS 269
Cdd:cd15954  166 ANIRVDAIYGLMVALLIGGFDILCISVSYAMILRAVVSLSSKEARSKAFSTCTAHICAiVITYTPAFFTFFAHRFGGHHI 245

                        250       260       270
                 ....*....|....*....|....*....|.
gi 602665565 270 TSVGTFIASVIFMVITPMLNPVIYSLKNNEV 300
Cdd:cd15954  246 TPHIHIIMANLYLLLPPMMNPIVYGVKTKQI 276

7tm_1

pfam00001

7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...

41-293

1.28e-27

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.

Pssm-ID: 459624 [Multi-domain] Cd Length: 256 Bit Score: 108.15 E-value: 1.28e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565   41 GNSLIILLILFDAHLCGlPMYFFLIQLSLVDICFSSATTPKMLEILLSKNK-TISYTECLLQLYLLITLANVDGFLLGSM 119
Cdd:pfam00001   1 GNLLVILVILRNKKLRT-PTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGDwPFGSALCKIVGALFVVNGYASILLLTAI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  120 AYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSleiSHFFCDIRELLSLSCsDVSIHQMI 199
Cdd:pfam00001  80 SIDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEG---NVTVCFIDFPEDLSK-PVSYTLLI 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  200 IFIegasVTLSPLVCILLSYVQILSNILKIPNAQG-------KYKAFSTCGSHILSVA-----FYFGSIMGVYFQPSSPE 267
Cdd:pfam00001 156 SVL----GFLLPLLVILVCYTLIIRTLRKSASKQKssertqrRRKALKTLAVVVVVFIlcwlpYHIVNLLDSLALDCELS 231

                         250       260
                  ....*....|....*....|....*.
gi 602665565  268 RSTSVGTFIASVIFMViTPMLNPVIY 293
Cdd:pfam00001 232 RLLDKALSVTLWLAYV-NSCLNPIIY 256

7tmA_OR52A-like

cd15955

olfactory receptor subfamily 52A and related proteins, member of the class A family of ...

31-300

2.70e-27

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320621 [Multi-domain] Cd Length: 276 Bit Score: 107.55 E-value: 2.70e-27

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  31 FLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLITLAN 110
Cdd:cd15955    7 FCIMFLLAVLGNCTLLIVIKRERSL-HQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 111 VDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQH-SFCGSLEISHFFCDIRELLSLS 189
Cdd:cd15955   86 FESGILLAMALDRYVAICHPLRHSSILTPQVLLGIGVLVVVRAVVLIIPCPLLIKLRlHHFRSTVISHSYCEHMAVVKLA 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 190 CSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPSSPERS 269
Cdd:cd15955  166 ADDVRVNKIYGLFVAFSILGFDIIFITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFAHRFGHHV 245

                        250       260       270
                 ....*....|....*....|....*....|.
gi 602665565 270 TSVGTFIASVIFMVITPMLNPVIYSLKNNEV 300
Cdd:cd15955  246 APYVHILLSNLYLLVPPVLNPIVYGVKTKQI 276

7tm_classA_rhodopsin-like

cd00637

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...

27-297

1.22e-17

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

Pssm-ID: 410626 [Multi-domain] Cd Length: 275 Bit Score: 81.18 E-value: 1.22e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  27 LFSLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLI 106
Cdd:cd00637    1 LAVLYILIFVVGLVGNLLVILVILRNRRL-RTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 107 TLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIRELL 186
Cdd:cd00637   80 VSLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPDLTLSK 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 187 slscsdvsIHQMIIFIegaSVTLSPLVCILLSYVQIL--------------SNILKIPNAQGKYKAFSTCGshILSVAFY 252
Cdd:cd00637  160 --------AYTIFLFV---LLFLLPLLVIIVCYVRIFrklrrhrrrirsssSNSSRRRRRRRERKVTKTLL--IVVVVFL 226

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 602665565 253 FG----SIMGVYFQPSSPERSTSVGTFIASVIFMVITPMLNPVIYSLKN 297
Cdd:cd00637  227 LCwlpyFILLLLDVFGPDPSPLPRILYFLALLLAYLNSAINPIIYAFFN 275

7tmA_amine_R-like

cd14967

amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

30-304

4.95e-13

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320098 [Multi-domain] Cd Length: 259 Bit Score: 67.59 E-value: 4.95e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  30 LFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLITLA 109
Cdd:cd14967    5 FLSLIILVTVFGNLLVILAVYRNRRL-RTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDVLCC 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 110 NVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLhtLLMSQHSFCGSLEISHFFCDIRELLSLS 189
Cdd:cd14967   84 TASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLP--PLVGWRDETQPSVVDCECEFTPNKIYVL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 190 CSDVsihqMIIFIegasvtlsPLVCILLSYVQILSNILKipnaqgKYKAFSTCGshILSVAFYFG----SIMGVYfQPSS 265
Cdd:cd14967  162 VSSV----ISFFI--------PLLIMIVLYARIFRVARR------ELKAAKTLA--IIVGAFLLCwlpfFIIYLV-SAFC 220

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 602665565 266 PERSTSVGTFIASVIFMVITPMLNPVIYSLKNNEVRNAM 304
Cdd:cd14967  221 PPDCVPPILYAVFFWLGYLNSALNPIIYALFNRDFRRAF 259

7tmA_SREB-like

cd15005

super conserved receptor expressed in brain and related proteins, member of the class A family ...

27-152

9.80e-07

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320134 [Multi-domain] Cd Length: 329 Bit Score: 49.76 E-value: 9.80e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  27 LFSLFLFMyLLTFLGNSLIILLILFDAHLCGLPmYFFLIQLSLVDICFSSATTP-KMLEILLSKNKTISYTECLLQLYLL 105
Cdd:cd15005    4 LTTLGLIL-CVSLAGNLLFSVLIVRDRSLHRAP-YYFLLDLCLADGLRSLACFPfVMASVRHGSGWIYGALSCKVIAFLA 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 602665565 106 ITLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLL 152
Cdd:cd15005   82 VLFCFHSAFTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTL 128

7tmA_GPR119_R_insulinotropic_receptor

cd15104

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...

37-152

3.41e-06

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320232 [Multi-domain] Cd Length: 283 Bit Score: 47.75 E-value: 3.41e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  37 LTFLGNSLIILLILFDAHLCGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLITLANVDGFLL 116
Cdd:cd15104   12 LIITGNLLVIVALLKLIRKKDTKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQKVLCLLRMCFVITSCAASVLSL 91

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 602665565 117 GSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLL 152
Cdd:cd15104   92 AAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLY 127

7tmA_CB2

cd15341

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...

30-159

1.02e-05

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 320463 [Multi-domain] Cd Length: 279 Bit Score: 46.37 E-value: 1.02e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  30 LFLFMYLLTFLGNSLIILLILFDAHLCGLPMYFFLIQLSLVDICFSSATTPKML-----------EILLSKNKTISYTec 98
Cdd:cd15341    6 LCTLCGLLCILENVAVLYLILSSPKLRRKPSYLFIGSLALADFLASVVFACSFVdfhvfhgvdssAIFLLKLGGVTMS-- 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 602665565  99 llqlylliTLANVDGFLLgsMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLL 159
Cdd:cd15341   84 --------FTASLGSLLL--MAFDRYVCIYYPSEYKALVTRKRALVALAVMWVLTALIAYL 134

7tmA_5-HT2_insect-like

cd15307

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...

30-307

3.31e-05

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320433 [Multi-domain] Cd Length: 279 Bit Score: 44.56 E-value: 3.31e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  30 LFLFMYLLTFLGNSLIILLILFDAHLCGLPMYFfLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLITLA 109
Cdd:cd15307    6 LALVLVLGTAAGNILVCLAIAWERRLQNVTNYF-LMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWICLDVLFC 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 110 NVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSfcgSLEISHFFCDIrellsls 189
Cdd:cd15307   85 TASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLSLMYSKDH---ASVLVNGTCQI------- 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 190 csDVSIHQMIifieGASVTLS-PLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAFYFGSIMGVYFQPSS--P 266
Cdd:cd15307  155 --PDPVYKLV----GSIVCFYiPLGVMLLTYCLTVRLLARQRSRHGRIIRLEQKATKVLGVVFFTFVILWSPFFVLNllP 228

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 602665565 267 ERSTSVGTFIASVIFMVIT------PMLNPVIYSLKNNEVRNAMKRV 307
Cdd:cd15307  229 TVCAECEERISHWVFDVVTwlgyasSMVNPIFYTIFNKVFRQAFKKV 275

7tmA_MC5R

cd15354

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...

30-150

3.50e-05

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320476 [Multi-domain] Cd Length: 270 Bit Score: 44.54 E-value: 3.50e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  30 LFLFMYLLTFLGNSLIILLILFDAHLCGlPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLITLA 109
Cdd:cd15354    6 VFLTLGIISLLENILVILAIVKNKNLHS-PMYFFVCSLAVADMLVSVSNAWETITIYLLNNRHLVIEDAFVRHIDNVFDS 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 602665565 110 NVDGFLLGSM------AYDRYVAICFPLNYVAIMTRKRCLELVAGSW 150
Cdd:cd15354   85 LICISVVASMcsllaiAVDRYVTIFYALRYHNIMTVRRAGIIIACIW 131

7tmA_CCK-BR

cd15979

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...

30-152

4.93e-05

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320645 [Multi-domain] Cd Length: 275 Bit Score: 44.03 E-value: 4.93e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  30 LFLFMYLLTFLGNSLIILLILFDAHLCGLPMYFfLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLITLA 109
Cdd:cd15979    6 LYSVIFLLSVFGNMLIIVVLGLNKRLRTVTNSF-LLSLALSDLMLAVFCMPFTLIPNLMGTFIFGEVICKAVAYLMGVSV 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 602665565 110 NVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLL 152
Cdd:cd15979   85 SVSTFSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLL 127

7tmA_MCR

cd15103

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...

30-150

8.26e-05

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320231 [Multi-domain] Cd Length: 270 Bit Score: 43.25 E-value: 8.26e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  30 LFLFMYLLTFLGNSLIILLILFDAHLCGlPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLITLA 109
Cdd:cd15103    6 VFLTLGIVSLLENILVILAIAKNKNLHS-PMYFFICSLAVADMLVSVSNALETIVIILLNNGYLVPRDSFEQHIDNVIDS 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 602665565 110 NVDGFLLGSM------AYDRYVAICFPLNYVAIMTRKRCLELVAGSW 150
Cdd:cd15103   85 MICSSLLASIcsllaiAVDRYITIFYALRYHSIMTVRRAGVIITAIW 131

7tmA_alpha1_AR

cd15062

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...

36-152

9.70e-05

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320190 [Multi-domain] Cd Length: 261 Bit Score: 43.25 E-value: 9.70e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  36 LLTFLGNSLIILLILFDAHLCGlPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLITLANVDGFL 115
Cdd:cd15062   12 LFAIGGNLLVILSVACNRHLRT-PTHYFIVNLAVADLLLSFTVLPFSATLEVLGYWAFGRIFCDVWAAVDVLCCTASIMS 90

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 602665565 116 LGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLL 152
Cdd:cd15062   91 LCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVL 127

7tmA_Adenosine_R

cd14968

adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...

36-228

1.27e-04

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.

Pssm-ID: 341316 [Multi-domain] Cd Length: 285 Bit Score: 43.01 E-value: 1.27e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  36 LLTFLGNSLIILLILFDAHLCGLPMYFfLIQLSLVDICFSSATTPkmLEILLSKNKTISYTECLLQLYLLITLANVDGFL 115
Cdd:cd14968   12 VLSVLGNVLVIWAVKLNRALRTVTNYF-IVSLAVADILVGALAIP--LAILISLGLPTNFHGCLFMACLVLVLTQSSIFS 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 116 LGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLlhTLLMSQHSFcGSLEISHFFCDIRELLSlscSDVSI 195
Cdd:cd14968   89 LLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGL--TPMFGWNNG-APLESGCGEGGIQCLFE---EVIPM 162

                        170       180       190
                 ....*....|....*....|....*....|...
gi 602665565 196 HQMIIFIEGASVtLSPLVCILLSYVQILSNILK 228
Cdd:cd14968  163 DYMVYFNFFACV-LVPLLIMLVIYLRIFRVIRK 194

7tmA_MC1R

cd15351

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...

30-151

1.45e-04

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320473 [Multi-domain] Cd Length: 271 Bit Score: 42.86 E-value: 1.45e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  30 LFLFMYLLTFLGNSLIILLILFDAHLCGlPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLITLA 109
Cdd:cd15351    6 LFLFLGLVSLVENILVVVAIAKNRNLHS-PMYYFICCLAVSDMLVSVSNLIETLFMLLLEHGVLVCRAPMLQHMDNVIDT 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 602665565 110 NVDGFL------LGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWL 151
Cdd:cd15351   85 MICSSVvsslsfLGAIAVDRYITIFYALRYHSIMTLQRAVNAIAGIWL 132

7tmA_Opsins_type2_animals

cd14969

type 2 opsins in animals, member of the class A family of seven-transmembrane G ...

28-155

2.07e-04

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.

Pssm-ID: 381741 [Multi-domain] Cd Length: 284 Bit Score: 42.19 E-value: 2.07e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  28 FSLFLFMY-LLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLI 106
Cdd:cd14969    3 LAVYLSLIgVLGVVLNGLVIIVFLKKKKL-RTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAVT 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 602665565 107 TLANVDGFLLGSMAYDRYVAICFPLNYVaIMTRKRCLELVAGSWLLPCL 155
Cdd:cd14969   82 FLGLVSISTLAALAFERYLVIVRPLKAF-RLSKRRALILIAFIWLYGLF 129

7tmA_Adenosine_R_A2B

cd15069

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...

29-152

2.19e-04

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320197 [Multi-domain] Cd Length: 294 Bit Score: 42.23 E-value: 2.19e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  29 SLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPkmLEILLSKNKTISYTECLLQLYLLITL 108
Cdd:cd15069    5 ALELIIAALSVAGNVLVCAAVGTNSTL-QTPTNYFLVSLAAADVAVGLFAIP--FAITISLGFCTDFHSCLFLACFVLVL 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 602665565 109 ANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLL 152
Cdd:cd15069   82 TQSSIFSLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVL 125

7tmA_D1-like_dopamine_R

cd15057

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...

33-303

2.79e-04

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320185 [Multi-domain] Cd Length: 299 Bit Score: 42.03 E-value: 2.79e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  33 FMYLLTFLGNSLIILLILFDAHLCGLPMYFFLIQLSLVDICFSSATTP-KMLEILLSKNKTISYTECLLQLYLLITLANV 111
Cdd:cd15057    9 LLVLLTLLGNALVIAAVLRFRHLRSKVTNYFIVSLAVSDLLVAILVMPwAAVNEVAGYWPFGSFCDVWVSFDIMCSTASI 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 112 DGFLLGSMayDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHF----FCD--IREL 185
Cdd:cd15057   89 LNLCVISV--DRYWAISSPFRYERRMTRRRAFIMIAVAWTLSALISFIPVQLGWHRADDTSEALALYadpcQCDssLNRT 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 186 LSLSCSDVSihqmiIFIegasvtlsPLVCILLSYvqilSNILKIPNAQGK-YKAFSTCGSHI--------------LSVA 250
Cdd:cd15057  167 YAISSSLIS-----FYI--------PVAIMIVTY----TRIYRIARRQIRrIAALERAAQEStnpdsslrsslrreTKAL 229

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 251 FYFGSIMGVY---------------FQPSSPERSTSVG--TFIASVIFMVITPMLNPVIYSLkNNEVRNA 303
Cdd:cd15057  230 KTLSIIMGVFvccwlpffilncvlpFCDLRTAQFPCVPdtTFIVFVWLGWANSSLNPIIYAF-NADFRKA 298

7tmA_alpha1B_AR

cd15326

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...

36-158

2.90e-04

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320449 [Multi-domain] Cd Length: 261 Bit Score: 41.80 E-value: 2.90e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  36 LLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLITLANVDGFL 115
Cdd:cd15326   12 LFAIVGNILVILSVVCNRHL-RIPTNYFIVNLAIADLLLSFTVLPFSATLEILGYWVFGRIFCDIWAAVDVLCCTASILS 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 602665565 116 LGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSL 158
Cdd:cd15326   91 LCAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVLSTVISI 133

7tmA_purinoceptor-like

cd14982

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...

114-304

3.29e-04

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341318 [Multi-domain] Cd Length: 283 Bit Score: 41.48 E-value: 3.29e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 114 FLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLhtLLMSQHSFCGSLEISHFFCDIRELLSLSCSDV 193
Cdd:cd14982   89 LFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASVP--LLLLRSTIAKENNSTTCFEFLSEWLASAAPIV 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 194 SIHQMIIFiegasvtLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVA-------------FYFGSIMGVY 260
Cdd:cd14982  167 LIALVVGF-------LIPLLIILVCYSLIIRALRRRSKQSQKSVRKRKALRMILIVLavflvcflpyhvtRILYLLVRLS 239

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 602665565 261 FQPSSPERSTSVGTFIASVIFMVITPMLNPVIYSLKNNEVRNAM 304
Cdd:cd14982  240 FIADCSARNSLYKAYRITLCLASLNSCLDPLIYYFLSKTFRKRL 283

7tmA_Ap5-HTB1-like

cd15065

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...

116-303

3.54e-04

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.

Pssm-ID: 320193 [Multi-domain] Cd Length: 300 Bit Score: 41.57 E-value: 3.54e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 116 LGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLL------HTLLMSQHSFCGSLEISHFFCdireLLSLS 189
Cdd:cd15065   90 LCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALISFLpihlgwHRLSQDEIKGLNHASNPKPSC----ALDLN 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 190 CSDVSIHQMIIFIEGASVTLSPLVCILL---SYVQILSNILKIPNAQGKYKAFSTCGSHILS------VAFYFGSIMGVY 260
Cdd:cd15065  166 PTYAVVSSLISFYIPCLVMLLIYSRLYLyarKHVVNIKSQKLPSESGSKFQVPSLSSKHNNQgvsdhkAAVTLGIIMGVF 245

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 602665565 261 FQPSSP-----ERSTSVGTFIASVIFMVITPM------LNPVIYSLKNNEVRNA 303
Cdd:cd15065  246 LICWLPffiinIIAAFCKTCIPPKCFKILTWLgyfnscLNPIIYSIFNSEFRRA 299

7tmA_mAChR_DM1-like

cd15301

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...

32-155

3.99e-04

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320428 [Multi-domain] Cd Length: 270 Bit Score: 41.35 E-value: 3.99e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  32 LFMYLLTFLGNSLIILLILFDAHLCGLPMYFfLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLITLANV 111
Cdd:cd15301    8 AVLSLVTVGGNVMVMISFKIDKQLQTISNYF-LFSLAVADFAIGVISMPLFTVYTALGYWPLGYEVCDTWLAIDYLASNA 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 602665565 112 DGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCL 155
Cdd:cd15301   87 SVLNLLIISFDRYFSVTRPLTYRARRTTKKAAVMIASAWIISLL 130

7tmA_Cannabinoid_R

cd15099

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...

29-159

4.34e-04

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 320227 [Multi-domain] Cd Length: 281 Bit Score: 41.36 E-value: 4.34e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  29 SLFLFMYLLTFLGNSLIILLILFDAHLCGLPMYFFLIQLSLVDICFSSATTPKMLEI-LLSKNKTISYTECLLQLYLLIT 107
Cdd:cd15099    5 VLCFLAGPVTFLENILVLLTILSSTALRRRPSYLFIGSLALADMLASVIFTISFLDFhVFHQRDSRNLFLFKLGGVTMAF 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 602665565 108 LANVDGFLLgsMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLL 159
Cdd:cd15099   85 TASVGSLLL--TALDRYLCIYQPSNYKLLVTRTRAKVAILLMWCVTIIISFL 134

7tmA_Adenosine_R_A2A

cd15068

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...

32-152

4.95e-04

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320196 [Multi-domain] Cd Length: 293 Bit Score: 41.08 E-value: 4.95e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  32 LFMYLLTFLGNSLIILLILFDAHLCGLPMYFfLIQLSLVDICFSSATTPkmLEILLSKNKTISYTECLLQLYLLITLANV 111
Cdd:cd15068    8 LAIAVLAILGNVLVCWAVWLNSNLQNVTNYF-VVSLAAADIAVGVLAIP--FAITISTGFCAACHGCLFIACFVLVLTQS 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 602665565 112 DGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLL 152
Cdd:cd15068   85 SIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVL 125

7tmA_TAAR2_3_4

cd15312

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...

114-157

5.17e-04

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320437 [Multi-domain] Cd Length: 289 Bit Score: 41.19 E-value: 5.17e-04

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 602665565 114 FLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHS 157
Cdd:cd15312   89 FHLCFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISWSVPCLFA 132

7tmA_CCK-AR

cd15978

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...

30-152

5.71e-04

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320644 [Multi-domain] Cd Length: 278 Bit Score: 41.01 E-value: 5.71e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  30 LFLFMYLLTFLGNSLIILLILFDAHLCGLpMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLITLA 109
Cdd:cd15978    6 LYSLIFLLSVLGNSLIIAVLIRNKRMRTV-TNIFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIFGSAVCKTATYFMGISV 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 602665565 110 NVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLL 152
Cdd:cd15978   85 SVSTFNLVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCL 127

7tmA_MC3R

cd15352

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...

30-151

7.43e-04

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320474 [Multi-domain] Cd Length: 272 Bit Score: 40.64 E-value: 7.43e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  30 LFLFMYLLTFLGNSLIILLILFDAHLCGlPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLITLA 109
Cdd:cd15352    6 VFLTLGIVSLLENILVILAVVKNKNLHS-PMYFFLCSLAVADMLVSVSNSLETIMIAVLNSGYLVISDQFIQHMDNVFDS 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 602665565 110 NVDGFLLGSM------AYDRYVAICFPLNYVAIMTRKRCLELVAGSWL 151
Cdd:cd15352   85 MICISLVASIcnllaiAVDRYVTIFYALRYHSIMTVRKALVLIAVIWV 132

7tmA_TRH-R

cd14995

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...

30-159

8.12e-04

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.

Pssm-ID: 320126 [Multi-domain] Cd Length: 269 Bit Score: 40.45 E-value: 8.12e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  30 LFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVD-ICFSSATTPKMLEILLSKNKTI-SYTECLLQLYLLIT 107
Cdd:cd14995    6 LVLLICGVGIVGNIMVVLVVLRTRHM-RTPTNCYLVSLAVADlMVLVAAGLPNEIESLLGPDSWIyGYAGCLLITYLQYL 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 602665565 108 LANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLL 159
Cdd:cd14995   85 GINASSLSITAFTIERYIAICHPMKAQFICTVSRAKKIICFVWIFTSLYCSP 136

7tmA_EDG-like

cd14972

endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...

30-304

8.54e-04

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 341317 [Multi-domain] Cd Length: 275 Bit Score: 40.35 E-value: 8.54e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  30 LFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDiCFSSATTPKMLEILLSKNKTISYTECLLQLYLLITLA 109
Cdd:cd14972    4 VAIVLGVFIVVENSLVLAAIIKNRRL-HKPMYILIANLAAAD-LLAGIAFVFTFLSVLLVSLTPSPATWLLRKGSLVLSL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 110 NVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLpclhSLLHTLLMSQHSFCGSLEIShffcdirellslS 189
Cdd:cd14972   82 LASAYSLLAIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVW----SVLLALLPVLGWNCVLCDQE------------S 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 190 CSDVSIH---QMIIFIegASVTLSPLVCILLSYVQILSNILKIPN--------AQGKYKAFSTCGSH---ILSVAFYFG- 254
Cdd:cd14972  146 CSPLGPGlpkSYLVLI--LVFFFIALVIIVFLYVRIFWCLWRHANaiaarqeaAVPAQPSTSRKLAKtvvIVLGVFLVCw 223

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 602665565 255 ---SIMGVYFQPSSPERSTSVGTFIASViFMVITPMLNPVIYSLKNNEVRNAM 304
Cdd:cd14972  224 lplLILLVLDVLCPSVCDIQAVFYYFLV-LALLNSAINPIIYAFRLKEMRRAV 275

7tmA_Gal2_Gal3_R

cd15097

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...

30-157

9.02e-04

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.

Pssm-ID: 320225 [Multi-domain] Cd Length: 279 Bit Score: 40.19 E-value: 9.02e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  30 LFLFMYLLTFLGNSLIILLILFDAHLCGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLITLA 109
Cdd:cd15097    6 VFSLIFLLGTVGNSLVLAVLLRSGQSGHNTTNLFILNLSVADLCFILFCVPFQATIYSLEGWVFGSFLCKAVHFFIYLTM 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 602665565 110 NVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHS 157
Cdd:cd15097   86 YASSFTLAAVSVDRYLAIRYPLRSRELRTPRNAVAAIALIWGLSLLFA 133

7tmA_TAARs

cd15055

trace amine-associated receptors, member of the class A family of seven-transmembrane G ...

120-159

1.47e-03

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320183 [Multi-domain] Cd Length: 285 Bit Score: 39.46 E-value: 1.47e-03

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 602665565 120 AYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLL 159
Cdd:cd15055   95 AIDRYVAVCDPLLYPTKITIRRVKICICLCWFVSALYSSV 134

7tmA_5-HT4

cd15056

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...

27-159

1.87e-03

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320184 [Multi-domain] Cd Length: 294 Bit Score: 39.39 E-value: 1.87e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  27 LFSLFLFMY-LLTFLGNSLIILLILFDAHLCGLPMYFfLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLL 105
Cdd:cd15056    2 VLSTFLSLViLLTILGNLLVIVAVCTDRQLRKKTNYF-VVSLAVADLLVAVLVMPFGAIELVNNRWIYGETFCLVRTSLD 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 602665565 106 ITLANVDGFLLGSMAYDRYVAICFPLnYVAIMTRKRCLELVAGSWLLPCLHSLL 159
Cdd:cd15056   81 VLLTTASIMHLCCIALDRYYAICCQP-LVYKMTPLRVAVMLGGCWVIPTFISFL 133

7tmA_Beta3_AR

cd15959

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...

29-159

2.27e-03

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.

Pssm-ID: 320625 [Multi-domain] Cd Length: 302 Bit Score: 39.12 E-value: 2.27e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  29 SLFLFMYLLTFLGNSLIILLILFDAHLCGLpMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLITL 108
Cdd:cd15959    5 ALLSLAILVIVGGNLLVIVAIAKTPRLQTM-TNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWTSVDVLC 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 602665565 109 ANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLL 159
Cdd:cd15959   84 VTASIETLCAIAVDRYLAITNPLRYEALVTKRRARTAVCLVWAISAAISFL 134

7tmA_Adenosine_R_A3

cd15070

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...

36-296

2.32e-03

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.

Pssm-ID: 320198 [Multi-domain] Cd Length: 280 Bit Score: 38.99 E-value: 2.32e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  36 LLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPkmLEILLSKNKTISYTECLLQLYLLITLANVDGFL 115
Cdd:cd15070   12 LCAVVGNVLVIWVVKLNPSL-RTTTFYFIVSLALADIAVGVLVIP--LAIVVSLGVTIHFYSCLFMSCLLVVFTHASIMS 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 116 LGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIRELLSLscsdvsi 195
Cdd:cd15070   89 LLAIAVDRYLRVKLTVRYRIVTTQRRIWLALGLCWLVSFLVGLTPMFGWNRKPSLESVNTTPLQCQFTSVMRM------- 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 196 hQMIIFIEGASVTLSPLVCILLSYVQI-------LSNILKIPNAQGKY--KAFSTCGSHILsVAFYFG------SIMG-- 258
Cdd:cd15070  162 -DYMVYFSFFTWILIPLVIMCALYVDIfyiirnkLSQNATGFRETGAFygREFKTAKSLAL-VLFLFAvcwlplSIINcv 239

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 602665565 259 VYFQPSSPERSTSVGTFIASvifmvITPMLNPVIYSLK 296
Cdd:cd15070  240 VYFNPKVPKIALYLGILLSH-----ANSMMNPIVYACK 272

7tmA_DmOct-betaAR-like

cd15066

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...

30-159

2.34e-03

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.

Pssm-ID: 320194 [Multi-domain] Cd Length: 265 Bit Score: 38.90 E-value: 2.34e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  30 LFLFMYLLTFLGNSLIILLILFDAHLCGLPMYFfLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLITLA 109
Cdd:cd15066    5 AMTLIILAAIFGNLLVIISVMRHRKLRVITNYF-VVSLAMADMLVALCAMTFNASVEITGRWMFGYFMCDVWNSLDVYFS 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 602665565 110 NVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLL 159
Cdd:cd15066   84 TASILHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLANVWISPALISFL 133

7tmA_alpha1A_AR

cd15325

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...

36-158

2.57e-03

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320448 [Multi-domain] Cd Length: 261 Bit Score: 38.72 E-value: 2.57e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  36 LLTFLGNSLIILLILFDAHLCGLpMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLITLANVDGFL 115
Cdd:cd15325   12 LFGVLGNILVILSVACHRHLQTV-THYFIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMS 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 602665565 116 LGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSL 158
Cdd:cd15325   91 LCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVISI 133

7tmA_OXR

cd15208

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...

27-222

3.33e-03

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.

Pssm-ID: 320336 [Multi-domain] Cd Length: 303 Bit Score: 38.52 E-value: 3.33e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  27 LFSLFLFMYLLTFLGNSLIILLILFDAHLCGLPMYFfLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLI 106
Cdd:cd15208    3 LIALYILVFIVGLVGNVLVCFAVWRNHHMRTVTNYF-IVNLSLADFLVIIICLPATLLVDVTETWFFGQVLCKIIPYLQT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 107 TLANVDGFLLGSMAYDRYVAICFPLNYVAimTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEISHFFCDIRELL 186
Cdd:cd15208   82 VSVSVSVLTLSCIALDRWYAICHPLMFKS--TAKRARVSILIIWIVSLLIMIPQAIVMECSRVVPLANKTILLTVCDERW 159

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 602665565 187 SLSCSDVSIHQMIIFIegasVTLSPLVCILLSYVQI 222
Cdd:cd15208  160 SDSIYQKVYHICFFLV----TYLLPLCLMILAYFQI 191

7tmA_Histamine_H1R

cd15050

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...

26-152

3.39e-03

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320178 [Multi-domain] Cd Length: 263 Bit Score: 38.56 E-value: 3.39e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  26 PLFSLFLFMYLLTFLGNSLIILLILFDAHLCGLPMYFfLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLL 105
Cdd:cd15050    2 PLGIALSTISLITVILNLLVLYAVRTERKLHTVGNLY-IVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSMD 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 602665565 106 ITLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLL 152
Cdd:cd15050   81 YVASTASIFSLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLL 127

7tmA_5-HT1_5_7

cd15064

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...

27-158

3.63e-03

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320192 [Multi-domain] Cd Length: 258 Bit Score: 38.46 E-value: 3.63e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  27 LFSLFL-FMYLLTFLGNSLIILLILFDAHLCGLPMYFfLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLL 105
Cdd:cd15064    2 LISVLLsLIILATILGNALVIAAILLTRKLHTPANYL-IASLAVADLLVAVLVMPLSAVYELTGRWILGQVLCDIWISLD 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 602665565 106 ITLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSL 158
Cdd:cd15064   81 VTCCTASILHLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISL 133

7tmA_5-HT6

cd15054

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...

33-163

3.79e-03

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320182 [Multi-domain] Cd Length: 267 Bit Score: 38.25 E-value: 3.79e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  33 FMYLLTFLGNSLIILLILFDAHLCGLPMYFfLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLITLANVD 112
Cdd:cd15054    9 LIILLTVAGNSLLILLIFTQRSLRNTSNYF-LVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPIWYAFDVMCCSAS 87

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 602665565 113 GFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLL 163
Cdd:cd15054   88 ILNLCVISLDRYLLIISPLRYKLRMTPPRALALILAAWTLAALASFLPIEL 138

7tmA_Vasopressin_Oxytocin

cd15196

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...

33-158

3.93e-03

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320324 [Multi-domain] Cd Length: 264 Bit Score: 38.37 E-value: 3.93e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  33 FMYLLTFLGNSlIILLILFDAHLCGLPMYFFLIQLSLVDICFSsattpkMLEILLSKNKTISY------TECLLQLYLLI 106
Cdd:cd15196    9 TILVLALFGNS-CVLLVLYRRRRKLSRMHLFILHLSVADLLVA------LFNVLPQLIWDITYrfyggdLLCRLVKYLQV 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 602665565 107 TLANVDGFLLGSMAYDRYVAICFPLNYVAImTRKRCLELVAGSWLLPCLHSL 158
Cdd:cd15196   82 VGMYASSYVLVATAIDRYIAICHPLSSHRW-TSRRVHLMVAIAWVLSLLLSI 132

7tmA_Beta_AR

cd15058

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...

36-159

4.26e-03

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320186 [Multi-domain] Cd Length: 305 Bit Score: 38.20 E-value: 4.26e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  36 LLTFLGNSLIILLILFDAHLCGLPMYFfLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLITLANVDGFL 115
Cdd:cd15058   12 LAIVVGNLLVIIAIARTSRLQTMTNIF-ITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCELWTSVDVLCVTASIET 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 602665565 116 LGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLL 159
Cdd:cd15058   91 LCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWIVSALVSFV 134

7tmA_CCKR-like

cd14993

cholecystokinin receptors and related proteins, member of the class A family of ...

119-181

4.30e-03

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.

Pssm-ID: 320124 [Multi-domain] Cd Length: 296 Bit Score: 38.35 E-value: 4.30e-03

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 602665565 119 MAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSL--EISHFFCD 181
Cdd:cd14993   94 ISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIMLPLLVVYELEEIISSEpgTITIYICT 158

7tmA_SREB3_GPR173

cd15217

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...

30-152

4.41e-03

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320345 [Multi-domain] Cd Length: 329 Bit Score: 38.39 E-value: 4.41e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  30 LFLFMYLLTFLGNSLIILLILFDAHLCGLPmYFFLIQLSLVDICFSSATTPKML-EILLSKNKTISYTECLLQLYLLITL 108
Cdd:cd15217    6 LLGLIICVSLAGNLIVSLLVLKDRALHKAP-YYFLLDLCLADTIRSAVCFPFVLvSIRNGSAWTYSVLSCKIVAFMAVLF 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 602665565 109 ANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLL 152
Cdd:cd15217   85 CFHAAFMLFCISVTRYMAIAHHRFYSKRMTFWTCIAVICMVWTL 128

7tmA_leucokinin-like

cd15393

leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...

36-162

5.82e-03

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.

Pssm-ID: 320515 [Multi-domain] Cd Length: 288 Bit Score: 37.77 E-value: 5.82e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  36 LLTFLGNSLIILLILFDAHLCGLPMYFFLiQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLITLANVDGFL 115
Cdd:cd15393   12 LVAVVGNFLVIWVVAKNRRMRTVTNIFIA-NLAVADIIIGLFSIPFQFQAALLQRWVLPRFMCPFCPFVQVLSVNVSVFT 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 602665565 116 LGSMAYDRYVAICFPLNyvAIMTRKRCLELVAGSWLLPCLHSLLHTL 162
Cdd:cd15393   91 LTVIAVDRYRAVIHPLK--ARCSKKSAKIIILIIWILALLVALPVAL 135

7tmA_5-HT7

cd15329

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...

27-158

5.93e-03

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320452 [Multi-domain] Cd Length: 260 Bit Score: 37.64 E-value: 5.93e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  27 LFSLFLFMYLLTFLGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLI 106
Cdd:cd15329    3 IGIVLLIIILGTVVGNALVIIAVCLVKKL-RTPSNYLIVSLAVSDLLVALLVMPLAIIYELSGYWPFGEILCDVWISFDV 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 602665565 107 TLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSL 158
Cdd:cd15329   82 LLCTASILNLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLLSALISI 133

7tmA_Galanin_R-like

cd14971

galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...

30-158

6.21e-03

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.

Pssm-ID: 320102 [Multi-domain] Cd Length: 281 Bit Score: 37.83 E-value: 6.21e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  30 LFLFMYLLTFLGNSLIILLILfdahlCGLPMY----FFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLL 105
Cdd:cd14971    6 FFALIFLLGLVGNSLVILVVA-----RNKPMRsttnLFILNLAVADLTFLLFCVPFTATIYPLPGWVFGDFMCKFVHYFQ 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 602665565 106 ITLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSL 158
Cdd:cd14971   81 QVSMHASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAA 133

7tmA_NPYR-like

cd15203

neuropeptide Y receptors and related proteins, member of the class A family of ...

26-224

6.54e-03

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.

Pssm-ID: 320331 [Multi-domain] Cd Length: 293 Bit Score: 37.58 E-value: 6.54e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  26 PLFSLFLFMYLLTFLGNSLIILLILFDAHLCGLPmYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLL 105
Cdd:cd15203    2 ILILLYGLIIVLGVVGNLLVIYVVLRNKSMQTVT-NIFILNLAVSDLLLCLVSLPFTLIYTLTKNWPFGSILCKLVPSLQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 106 ITLANVDGFLLGSMAYDRYVAICFPLNyvAIMTRKRCLELVAGSWLLPCLHSLlhTLLMSQHSFCGSLEISHFFCDIrel 185
Cdd:cd15203   81 GVSIFVSTLTLTAIAIDRYQLIVYPTR--PRMSKRHALLIIALIWILSLLLSL--PLAIFQELSDVPIEILPYCGYF--- 153

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 602665565 186 lslsCSDVSIHQMIIFIEGASVTLS----PLVCILLSYVQILS 224
Cdd:cd15203  154 ----CTESWPSSSSRLIYTISVLVLqfviPLLIISFCYFRISL 192

7tmA_PR4-like

cd15392

neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...

111-158

6.74e-03

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.

Pssm-ID: 320514 [Multi-domain] Cd Length: 287 Bit Score: 37.72 E-value: 6.74e-03

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 602665565 111 VDGFLLGSMAYDRYVAICFPLnyVAIMTRKRCLELVAGSWLLPCLHSL 158
Cdd:cd15392   87 VSAFTLVAISIDRYVAIMWPL--RPRMTKRQALLLIAVIWIFALATAL 132

7tmA_Octopamine_R

cd15063

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...

28-152

7.55e-03

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.

Pssm-ID: 320191 [Multi-domain] Cd Length: 266 Bit Score: 37.48 E-value: 7.55e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  28 FSLFLFMYLLTFLGNSLIILLILFDAHLCGLpMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLLIT 107
Cdd:cd15063    4 LLVLTFLNVLVVLGNLLVIAAVLCSRKLRTV-TNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVDVW 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 602665565 108 LANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLL 152
Cdd:cd15063   83 MCTASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVL 127

7tmA_NPSR

cd15197

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...

24-158

8.89e-03

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).

Pssm-ID: 320325 [Multi-domain] Cd Length: 294 Bit Score: 37.40 E-value: 8.89e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  24 EGPLFSLFLFMYLLTflGNSLIILLILFDAHLcGLPMYFFLIQLSLVDICFSSATTpkMLEILLskNKTISYTE----CL 99
Cdd:cd15197    2 EQLATLWVLFVFIVV--GNSSVLFALWMRKAK-KSRMNFFITQLAIADLCVGLINV--LTDIIW--RITVEWRAgdfaCK 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 602665565 100 LQLYLLITLANVDGFLLGSMAYDRYVAICFPLNYVAimTRKRCLELVAGSWLLPCLHSL 158
Cdd:cd15197   75 VIRYLQVVVTYASTYVLVALSIDRYDAICHPMNFSQ--SGRQARVLICVAWILSALFSI 131

7tmA_Trissin_R

cd15012

trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...

26-304

9.10e-03

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320140 [Multi-domain] Cd Length: 277 Bit Score: 37.04 E-value: 9.10e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  26 PLFSLFLFMYLLTFLGNsLIILLILFDAHLCGLPMYFFLIQLSLVDICFSSATTPKMLEILLSKNKTISYTECLLQLYLL 105
Cdd:cd15012    1 IFIILYTLVFCCCFFGN-LLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVH 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 106 ITLANVDGFLLGSMAYDRYVAICFPLNYVAIMTRKRCLELVAGSWLLPCLHSLLHTLLMSQHSFCGSLEIShffCDIREL 185
Cdd:cd15012   80 SLSYTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPYFVFSQTVEILVTQDGQ---EEEICV 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 186 LSLSCSDVSIHQMIIFIegaSVTLSPLVCILLSYVQILSNILKIPNAQGKYKAFSTCGSHILSVAF----YFGSIMGVYF 261
Cdd:cd15012  157 LDREMFNSKLYDTINFI---VWYLIPLLIMTVLYSKISIVLWKSSSIEARRKVVRLLVAVVVSFALcnlpYHARKMWQYW 233

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 602665565 262 QpsSPERSTSVGTFIASVI---FMVITPMLNPVIYSLKNNEVRNAM 304
Cdd:cd15012  234 S--EPYRCDSNWNALLTPLtflVLYFNSAVNPLLYAFLSKRFRQSM 277

7tmA_Vasopressin-like

cd14986

vasopressin receptors and its related G protein-coupled receptors, member of the class A ...

34-293

9.22e-03

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.

Pssm-ID: 320117 [Multi-domain] Cd Length: 295 Bit Score: 37.36 E-value: 9.22e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565  34 MYLLTFLGNSLIILLiLFDAHLCGLPMYFFLIQLSLVDICFS----------SATTPKMLEILLSKnkTISYTECLLQLY 103
Cdd:cd14986   10 LFVFTLVGNGLVILV-LRRKRKKRSRVNIFILNLAIADLVVAfftvltqiiwEATGEWVAGDVLCR--IVKYLQVVGLFA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 104 LLitlanvdgFLLGSMAYDRYVAICFPLNYVAimTRKRCLELVAGSWLLPCLHSLLHTLLMSQHsfcgslEISHFFCDIR 183
Cdd:cd14986   87 ST--------YILVSMSLDRYQAIVKPMSSLK--PRKRARLMIVVAWVLSFLFSIPQLVIFVER------ELGDGVHQCW 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602665565 184 ELLslscSDVSIHQMIIFIEGASVTLSPLVCILLSYVQILSNILK--------IPNAQGKYKAFSTCGSH---------- 245
Cdd:cd14986  151 SSF----YTPWQRKVYITWLATYVFVIPLIILSYCYGRILRTIWIrsrqktdrPIAPTAMSCRSVSCVSSrvslisraki 226

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 602665565 246 -------ILSVAF------YFGSIMGVYFQPSSPERSTsvgTFIASVIFMVITPMLNPVIY 293
Cdd:cd14986  227 ktikmtlVIILAFilcwtpYFIVQLLDVYAGMQQLEND---AYVVSETLASLNSALNPLIY 284

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01