|
Name |
Accession |
Description |
Interval |
E-value |
| squalene_cyclas |
TIGR01787 |
squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the ... |
76-721 |
0e+00 |
|
squalene/oxidosqualene cyclases; This family of enzymes catalyzes the cyclization of the triterpenes squalene or 2-3-oxidosqualene to a variety of products including hopene, lanosterol, cycloartenol, amyrin, lupeol, and isomultiflorenol.
Pssm-ID: 273809 [Multi-domain] Cd Length: 621 Bit Score: 1006.20 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 76 GALNGMTFYVGLQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLPaGYKEEIVRYLRSVQLPDGGWGLHIEDKSTVFGTA 155
Cdd:TIGR01787 1 TARRAVEFLLSLQAPDGYWWGELEGPLTLLAEYVLLCHIADTPLP-GYREKIVRYLRHHQNEDGGWGLHIGGKSTVFGTV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 156 LNYVSLRILGVGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQ 235
Cdd:TIGR01787 80 LAYVALKILGMSPDDPAMVRARNFILKQGGAVASPVFTKFWLALLGVYPWEGVPPLPPEIMLLPKWLPIHPSKSWCRCRM 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 236 VYLPMSYCYAIRLSATEDPlvqslRQELYVEDfASIdwPAQRNNVAPDELYTPHSWLLHVVYALLNL-YERHHSAHLRQR 314
Cdd:TIGR01787 160 VYLPMSYCYGERLSAPIDP-----REELYVED-DSI--RAQRNNVAKEDLYTPHSWLLRALYGLLNLfYHPFLRKALRKR 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 315 AVQKLYEHIVADDrftksiSIGPISKTINMLVRWYVDGPASTAFQEHVSRIPDYLWMGLDGMKMQGTnGSQIWDTAFAIQ 394
Cdd:TIGR01787 232 ALQWLYEHIAADG------SIGPISKAMAMLALWFLDGPNSPAFQKHLQRIDDYLWLQLDGMKMQGT-GSQVWDTAFAIQ 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 395 ALLEAGGHHRPEFSSCLQKAHEFLRLSQVPDNPPDYQKYYRQMRK-GGFSFSTLDCGW-IVADCTAEALKAVLLLQEkcp 472
Cdd:TIGR01787 305 ALRESGDHRLPEFHPALVKAHEWLLLSQIPDNPPGDWKVYRHNLKpGGWAFSFLNCGYpDVDDTAVVALKAVLLLQE--- 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 473 yvTEHIPRERLCDAVAVLLSMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKYFhthfpDHR 552
Cdd:TIGR01787 382 --DEHVKRDRLRDAVNWILGMQSSNGGFAAYDPDNTGEWLELLNPSEVFGDIMIDPPYVDVTARVIQALGAF-----GHR 454
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 553 AAEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtaCAEVSRACDFLLSRQMADGGWGED 632
Cdd:TIGR01787 455 ADEIRNVLERALEYLRREQRADGSWFGRWGVNYTYGTGFVLSALAAAGRTYRN---CPEVQKACDWLLSRQMPDGGWGED 531
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 633 FESCEERRYVQSAQSQIHNTCWALMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENISGVFN-KSCAISYTSYRNVF 711
Cdd:TIGR01787 532 CFSYEDPSYVGSGGSTPSQTGWALMALIAAGEADSEAIERGVKYLLETQRPDGDWPQEYITGVGFpKNFYLKYTNYRNIF 611
|
650
....*....|
gi 635024088 712 PIWALGRFSQ 721
Cdd:TIGR01787 612 PLWALGRYRQ 621
|
|
| SQCY_1 |
cd02892 |
Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an ... |
77-719 |
0e+00 |
|
Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. This group contains bacterial SQCY which catalyzes the convertion of squalene to hopene or diplopterol and eukaryotic OSQCY which transforms the 2,3-epoxide of squalene to compounds such as, lanosterol in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain.
Pssm-ID: 239222 [Multi-domain] Cd Length: 634 Bit Score: 937.77 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 77 ALNGMTFYVGLQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLPAGYKEEIVRYLRSVQLPDGGWGLHIEDKSTVFGTAL 156
Cdd:cd02892 1 IRRALEFLLSLQAPDGHWPGELEGPLFITAEYILLLYILGIPIDPEHRKEIARYLRNHQNPDGGWGLHHEGPSTMFGTVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 157 NYVSLRILGVGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQV 236
Cdd:cd02892 81 NYVALRLLGVSPDDPHMVKARNWILSHGGAARIPVWGKIWLALLGVYPWEGVPPLPPELWLLPSWLPFHPYKFWCWARTV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 237 YLPMSYCYAIRLSATEDPLVQSLRQELYVEDFASIDWPAQRNNVAPdeLYTPHSWLLHVVYALLNLYERHHSAHLRQRAV 316
Cdd:cd02892 161 YVPMSYLYGKRPVAPITPLVLSLRDELYVEPYEKINWYKHRNDLYD--YRPPWQRLFDALDRLLHWYEPLPPKPLRRKAL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 317 QKLYEHIVADDRFTKSISIGPISKTINMLVRWYVDGPASTAFQEHVSRIPDYLWMGLDGMKMQGTNGSQIWDTAFAIQAL 396
Cdd:cd02892 239 RKAYEWILYRDENTGYLGIIPPPKANNMLALWVLGYPDSPAFKRHLERIDDFLWLGPEGMKMCQTNGSQVWDTALAVQAL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 397 LEAGGHhrPEFSSCLQKAHEFLRLSQVPDNPPDYQKYYRQMRKGGFSFSTLDCGWIVADCTAEALKAVLLLQEKCPYvTE 476
Cdd:cd02892 319 LEAGLA--PEFDPALKKALDWLLESQILDNPGDWKVKYRHLRKGGWAFSTANQGYPDSDDTAEALKALLRLQELPPF-GE 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 477 HIPRERLCDAVAVLLSMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKYFHTHFPDHRaAEI 556
Cdd:cd02892 396 KVSRERLYDAVDWLLGMQNSNGGFAAFEPDNTYHWLENLNPFEDFGDIMIDPPYVECTGSVLEALGLFGKLYPGHR-REI 474
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 557 RETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtaCAEVSRACDFLLSRQMADGGWGEDFESC 636
Cdd:cd02892 475 DPAIRRAVKYLLREQEPDGSWYGRWGVCYIYGTWFALEALAAAGEDYEN---SPYIRKACDFLLSKQNPDGGWGESYLSY 551
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 637 EERRYVQSAQSQIHNTCWALMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENISGVFNKSCAISYTSYRNVFPIWAL 716
Cdd:cd02892 552 EDKSYAGGGRSTVVQTAWALLALMAAGEPDSEAVERGIKYLLNTQLPDGDWPQEEITGVGFPNFYIRYHNYRNYFPLWAL 631
|
...
gi 635024088 717 GRF 719
Cdd:cd02892 632 GRY 634
|
|
| osq_cycl |
TIGR03463 |
2,3-oxidosqualene cyclase; This model identifies 2,3-oxidosqualene cyclases from Stigmatella ... |
87-719 |
0e+00 |
|
2,3-oxidosqualene cyclase; This model identifies 2,3-oxidosqualene cyclases from Stigmatella aurantiaca which produces cycloartenol, and Gemmata obscuriglobus and Methylococcus capsulatus, which each produce the closely related sterol, lanosterol.
Pssm-ID: 274591 [Multi-domain] Cd Length: 634 Bit Score: 617.39 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 87 LQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLPAGYKEEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVSLRILGV 166
Cdd:TIGR03463 4 LQDSAGDWEGDMGGCQFIIAIAVAGLHVMGRPPDAEERAAIIAHFELHQLADGAWGLDPEAPGQVFFSVLAYVALRLLGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 167 GPDDPDLVRARNILH-KKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQVYLPMSYCYA 245
Cdd:TIGR03463 84 GKDDAGLARARAWFHaQPEGPKASGAWGKFILALLGLYEREGLNAVPPELFLLPESLPFHPSRFWCHCRLIYLGIAWLSG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 246 IRLSATE-DPLVQSLRQELYVEDFASIDWPAQRNNVAPDELYTPHSWLLHVVYALLNLYERHHSAHLRQRAVQKLYEHIV 324
Cdd:TIGR03463 164 RGARAPEsDPLLAAIRQEIFAEGYEQVDFGAARERVAPTDLFTPISFVLKAANDLLAGYERLAGKALRARALDFAFEQIL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 325 ADDRFTKSISIGPISKTINMLVrWYVDGPASTAFQEHVSRIPDYLWMGLD-GMKMQGTNGSQIWDTAFAIQALLEAG--- 400
Cdd:TIGR03463 244 AEDEATHYICIGPINGLLNCLA-IFAHDPDGPDLAAHLEGLEAWFWEDDAeGLRMNGANSNALWDTAFAVQALAALGeld 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 401 GHHRpefsSCLQKAHEFLRLSQVPDNPPDYQKYYRQMRKGGFSFSTLDCGWIVADCTAEALKAVLLLQEK-CPYVTEHIP 479
Cdd:TIGR03463 323 EEAK----HALEEAAAFIDAAQMLADLADPQEAFRDPAKGGWCFSDGDHCWPISDCAAEALKALFALEELgDNRISEALG 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 480 RERLCDAVAVLLSMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKYFHTHFPDHRAAEIRET 559
Cdd:TIGR03463 399 AARLQDAVEFILSMQNADGGFATYELQRGGKLLELLNPSDMFGQCMTDLSYVECTAACLGALAAWLKHHPDLPDAKIDAA 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 560 LTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtacAEVSRACDFLLSRQMADGGWGEDFESCEER 639
Cdd:TIGR03463 479 IRKAEEFIRRRQLDDGSFMGFWGICFTYATFFGAKGLIAAGAEPAD----MALQAAAAFLLEKQRADGAWGEHVESCLEA 554
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 640 RYVQSAQSQIHNTCWALMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENISGVFNKSCAISYTSYRNVFPIWALGRF 719
Cdd:TIGR03463 555 RWVEGKHGHAVMTAWALLALAAAGEAAHDAAERGIAWLCEQQGEDGGWPPEGIAGIFFGAAAIDYDAYLRIFPTWALARC 634
|
|
| PLN03012 |
PLN03012 |
Camelliol C synthase |
72-724 |
0e+00 |
|
Camelliol C synthase
Pssm-ID: 166653 [Multi-domain] Cd Length: 759 Bit Score: 590.84 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 72 TACEGALNGMTFYVGLQAEDGHW----TGDYGGPLFLLPGLLITCHVARIpLPAGYKEEIVRYLRSVQLPDGGWGLHIED 147
Cdd:PLN03012 94 IATNALRKGIHFFSALQASDGHWpaenAGPLFFLPPLVFCLYITGHLDEI-FTQDHRKEILRYIYCHQKEDGGWGLHIEG 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 148 KSTVFGTALNYVSLRILGVGPD---DPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPA 224
Cdd:PLN03012 173 HSTMFCTTLNYICMRILGEGPDgghDNACGRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPSFFPI 252
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 225 HPSTLWCHCRQVYLPMSYCYAIRLSATEDPLVQSLRQELYVEDFASIDWPAQRNNVAPDELYTPHSWLLHVVYALLNLYE 304
Cdd:PLN03012 253 HPAKMWCYCRLVYLPMSYLYGKRFVGPISPLILQLREEIYLQPYAEINWMKARHLCAKEDAYCPHPLIQDLIWDCLYIFA 332
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 305 RHHSAH------LRQRAVQKLYEHIVADDRFTKSISIGPISKTINMLVRWyVDGPASTAFQEHVSRIPDYLWMGLDGMKM 378
Cdd:PLN03012 333 EPFLACwpfnklLREKALGLAMKHIHYEDENSRYITIGCVEKALCMLACW-VEDPNGDHFKKHLLRISDYLWIAEDGMKM 411
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 379 QgTNGSQIWDTAFAIQALLEAggHHRPEFSSCLQKAHEFLRLSQVPDNPP-DYQKYYRQMRKGGFSFSTLDCGWIVADCT 457
Cdd:PLN03012 412 Q-SFGSQLWDSGFALQALLAS--NLSNEIPDVLRRGHDFIKNSQVGENPSgDFKNMYRHISKGAWTFSDRDHGWQASDCT 488
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 458 AEALKAVLLLQEKCP-YVTEHIPRERLCDAVAVLLSMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSA 536
Cdd:PLN03012 489 AEGFKCCLLFSMIAPdIVGPKMDPEQLHDAVNILLSLQSKNGGMTAWEPAGAPEWLELLNPTEMFADIVIEHEYNECTSS 568
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 537 VMQALKYFHTHFPDHRAAEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtaCAEVSRAC 616
Cdd:PLN03012 569 AIQALILFKQLYPDHRTEEINAFIKKAAEYIENIQMLDGSWYGNWGICFTYGTWFALAGLAAAGKTFND---CEAIRKGV 645
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 617 DFLLSRQMADGGWGEDFESCEERRYVQSA--QSQIHNTCWALMGLM----AVRHPdiEAQERGVRCLLEKQLPNGDWPQE 690
Cdd:PLN03012 646 HFLLAAQKDNGGWGESYLSCPKKIYIAQEgeISNLVQTAWALMGLIhagqAERDP--IPLHRAAKLIINSQLENGDFPQQ 723
|
650 660 670
....*....|....*....|....*....|....
gi 635024088 691 NISGVFNKSCAISYTSYRNVFPIWALGRFSQLYP 724
Cdd:PLN03012 724 EATGAFLKNCLLHYAAYRNIFPLWALAEYRARVP 757
|
|
| SqhC |
COG1657 |
Terpene cyclase SqhC [Lipid transport and metabolism]; |
75-723 |
0e+00 |
|
Terpene cyclase SqhC [Lipid transport and metabolism];
Pssm-ID: 441263 [Multi-domain] Cd Length: 644 Bit Score: 567.91 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 75 EGALNGMTFYVGLQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLPAGYKEEIVRYLRSVQLPDGGWGLHIEDKSTVFGT 154
Cdd:COG1657 22 DAAIAAAQALLLQQQDDGGWWGGELEADVTIAAEYILLHHFLGPDDEELEAKIARYLRRQQNDDGGWPLYHGGPGDLSTT 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 155 ALNYVSLRILGVGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCR 234
Cdd:COG1657 102 VKAYFALKLLGDDPDAPHMVRAREFILARGGAARANVFTKIWLALFGQYPWRGVPALPPEIMLLPRWFPFHIYKFSYWAR 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 235 QVYLPMSYCYAIRLSATEDPLVqsLRQELYVEDFASID--WPAQRNnvapdelYTPHSWLLHVVYALLNLYERHHSAHLR 312
Cdd:COG1657 182 TVIVPLLILYARKPVAPLPPGV--GIDELFVEPPEQVDyyFPAPRD-------RSPWSRFFLALDRLLRAYERLPPKPLR 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 313 QRAVQKLYEHIvaDDRFTKS---ISIGP-ISKTINMLvRWYVDGPASTAFQEHVSRIPDYLWMGLDGMKMQGtNGSQIWD 388
Cdd:COG1657 253 RRALRKAEDWI--LERLEGDgglGGIFPaMVNSLMAL-LALGYPPDHPVVRRALEALEKLLVETEDGARCQP-CVSPVWD 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 389 TAFAIQALLEAGghhRPEFSSCLQKAHEFLRLSQVPDnPPDYQKYYRQMRKGGFSFSTLDCGWIVADCTAEALKAVLLLQ 468
Cdd:COG1657 329 TALAVQALQEAG---LPEDHPALERAADWLLSKQILV-KGDWAVKRPDVEPGGWAFQFANDHYPDVDDTAVVLMALLRLR 404
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 469 EKcpyvTEHIPRERLCDAVAVLLSMRNPDGGFATYETKRGGHLLELLNPSEvFGdIMIDYTYVECTSAVMQALKYFhthf 548
Cdd:COG1657 405 LP----DEPRYREAIERAVEWILGMQSRDGGWGAFDKDNTKEWLNKIPFAD-HG-ALLDPPTADVTARCLEMLGQL---- 474
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 549 pdhRAAEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtacAEVSRACDFLLSRQMADGG 628
Cdd:COG1657 475 ---GLTEDHPAIRRAVAYLRREQEPDGSWFGRWGVNYIYGTWSVLTGLNAAGVDPDD----PAIRRAVAWLLSIQNADGG 547
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 629 WGEDFESCEERRYVQSAQSQIHNTCWALMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENISGV-FNKSCAISYTSY 707
Cdd:COG1657 548 WGEDCRSYEDPRYVGLGPSTASQTAWALLALLAAGEADSPAVARGIAYLLSTQREDGSWDEEYFTGTgFPRVFYLRYHLY 627
|
650
....*....|....*.
gi 635024088 708 RNVFPIWALGRFSQLY 723
Cdd:COG1657 628 RQYFPLWALARYRNLR 643
|
|
| PLN02993 |
PLN02993 |
lupeol synthase |
80-719 |
0e+00 |
|
lupeol synthase
Pssm-ID: 215537 [Multi-domain] Cd Length: 763 Bit Score: 556.83 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 80 GMTFYVGLQAEDGHW----TGDYGGPLFLLPGLLITCHVARIpLPAGYKEEIVRYLRSVQLPDGGWGLHIEDKSTVFGTA 155
Cdd:PLN02993 102 GVSFFSALQASDGHWpgeiTGPLFFLPPLVFCLYITGHLEEV-FDAEHRKEMLRHIYCHQNEDGGWGLHIESKSVMFCTV 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 156 LNYVSLRILGVGPD---DPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCH 232
Cdd:PLN02993 181 LNYICLRMLGEGPNggrENACKRARQWILDHGGVTYIPSWGKFWLSILGIYDWSGTNPMPPEIWLLPSFLPIHLGKTLCY 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 233 CRQVYLPMSYCYAIRLSATEDPLVQSLRQELYVEDFASIDWPAQRNNVAPDELYTPHSWLLHVVYALLNLYERHHSAH-- 310
Cdd:PLN02993 261 TRMVYMPMSYLYGKRFVGPITPLIMLLREELHLQPYEEINWNKARRLCAKEDMYYPHPLVQDLIWDTLHNFVEPFLTRwp 340
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 311 ----LRQRAVQKLYEHIVADDRFTKSISIGPISKTINMLVRWyVDGPASTAFQEHVSRIPDYLWMGLDGMKMQgTNGSQI 386
Cdd:PLN02993 341 lnklVREKALQVAMKHIHYEDENSHYITIGCVEKVLCMLACW-IENPNGDHFKKHLARIPDYMWVAEDGMKMQ-SFGSQL 418
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 387 WDTAFAIQALLEAggHHRPEFSSCLQKAHEFLRLSQVPDNPP-DYQKYYRQMRKGGFSFSTLDCGWIVADCTAEALKAVL 465
Cdd:PLN02993 419 WDTGFAIQALLAS--DLSDETDDVLRRGHNYIKKSQVRENPSgDFKSMYRHISKGAWTLSDRDHGWQVSDCTAEALKCCM 496
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 466 LLQEKCPYVT-EHIPRERLCDAVAVLLSMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKYF 544
Cdd:PLN02993 497 LLSMMPADVVgQKIDPEQLYDSVNLLLSLQSENGGVTAWEPVRAYKWLELLNPTDFFANTMVEREYVECTSAVIQALVLF 576
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 545 HTHFPDHRAAEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtaCAEVSRACDFLLSRQM 624
Cdd:PLN02993 577 KQLYPDHRTKEIIKSIEKAVQFIESKQTPDGSWYGNWGICFIYATWFALGGLAAAGKTYND---CLAMRKGVHFLLTIQR 653
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 625 ADGGWGEDFESCEERRYV--QSAQSQIHNTCWALMGLMAVRHP--DIEAQERGVRCLLEKQLPNGDWPQENISGVFNKSC 700
Cdd:PLN02993 654 DDGGWGESYLSCPEQRYIplEGNRSNLVQTAWAMMGLIHAGQAerDLIPLHRAAKLIITSQLENGDFPQQEILGAFMNTC 733
|
650
....*....|....*....
gi 635024088 701 AISYTSYRNVFPIWALGRF 719
Cdd:PLN02993 734 MLHYATYRNTFPLWALAEY 752
|
|
| SQCY |
cd02889 |
Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - ... |
384-719 |
9.69e-174 |
|
Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. Bacterial SQCY catalyzes the convertion of squalene to hopene or diplopterol. Eukaryotic OSQCY transforms the 2,3-epoxide of squalene to compounds such as, lanosterol (a metabolic precursor of cholesterol and steroid hormones) in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain. This group also contains SQCY-like archael sequences and some bacterial SQCY's which lack this minor domain.
Pssm-ID: 239219 [Multi-domain] Cd Length: 348 Bit Score: 501.36 E-value: 9.69e-174
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 384 SQIWDTAFAIQALLEAGGHhrPEFSSCLQKAHEFLRLSQVPDNPPDYQKYYRQMRKGGFSFSTLDCGWIVADCTAEALKA 463
Cdd:cd02889 23 SQVWDTALALQALLEAGLA--PEFDPALKKALEWLLKSQIRDNPDDWKVKYRHLRKGGWAFSTANQGYPDSDDTAEALKA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 464 VLLLQEKCPYvTEHIPRERLCDAVAVLLSMRNPDGGFATYETKRGGHLLELlnPSEVFGDIMIDYTYVECTSAVMQALKY 543
Cdd:cd02889 101 LLRLQKKPPD-GKKVSRERLYDAVDWLLSMQNSNGGFAAFEPDNTYKYLEL--IPEVDGDIMIDPPYVECTGSVLEALGL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 544 FHTHFPDHRAaEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRdgtaCAEVSRACDFLLSRQ 623
Cdd:cd02889 178 FGKLYPEHRR-EIDPAIRRAVKYLEREQEPDGSWYGRWGVCFIYGTWFALEALAAAGEDEN----SPYVRKACDWLLSKQ 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 624 MADGGWGEDFESCEERRYVQSAQSQIHNTCWALMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENISGVFNKSCAIS 703
Cdd:cd02889 253 NPDGGWGESYESYEDPSYAGGGRSTVVQTAWALLALMAAGEPDSEAVKRGVKYLLNTQQEDGDWPQEEITGVFFKNFYIR 332
|
330
....*....|....*.
gi 635024088 704 YTSYRNVFPIWALGRF 719
Cdd:cd02889 333 YHNYRNYFPLWALGRY 348
|
|
| hopene_cyclase |
TIGR01507 |
squalene-hopene cyclase; SHC is an essential prokaryotic gene in hopanoid (triterpenoid) ... |
83-722 |
2.36e-63 |
|
squalene-hopene cyclase; SHC is an essential prokaryotic gene in hopanoid (triterpenoid) biosynthesis. Squalene hopene cyclase, an integral membrane protein, directly cyclizes squalene into hopanoid products. [Fatty acid and phospholipid metabolism, Other]
Pssm-ID: 273661 [Multi-domain] Cd Length: 635 Bit Score: 222.84 E-value: 2.36e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 83 FYVGLQAEDGHWTGDYGGPLFLLPGLLITCH----VARIPLpagykEEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNY 158
Cdd:TIGR01507 24 YLLSCQKDEGYWWGELESNVTIEAEYVLLCHildrVDRDRM-----EKIRNYLLHEQREDGTWALYPGGPGDLSTTVEAY 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 159 VSLRILGVGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQVYL 238
Cdd:TIGR01507 99 VALKYIGMSRDEPPMQKALRFIQSQGGIESSRVFTRMWLALVGEYPWRGVPMVPPEIMLLPKRFPFNIYEFSSWARATVV 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 239 PMSYCYAIRLSAtedPLVQSLR-QELYVEDfasidwpaqrnnVAPDELYTPHS---W-LLHVVYALLNLYERHHSAHLRQ 313
Cdd:TIGR01507 179 PLSIVCSRKPVF---PLPERARvPELYETD------------VPKPRRRGAKGgtgWgIFDALDRALHGYEKLSVHPFRR 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 314 RAVQKLYEHIVAddRFTKSISIGPISKT-INMLVRWYVDG-PASTAF-QEHVSRIPDYLWMGLDGMKMQGTNgSQIWDTA 390
Cdd:TIGR01507 244 AAEIRALDWLLE--RQAGDGSWGGIQPAmFNALIALKILGmTQHDAFiKLGWEGIDLYGVELDDSWMFQACV-SPVWDTA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 391 FAIQALLEAGghhRPEFSSCLQKAHEFLRLSQVpDNPPDYQKYYRQMRKGGFSFSTLDCGWIVADCTAEALKAVLLLQEK 470
Cdd:TIGR01507 321 LAVLALREAG---LPADHDALVKAGEWLLDKQI-TVPGDWAVKRPNLEPGGWAFQFDNVYYPDVDDTAVVVWALNGLRLP 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 471 cpyvTEHIPRERLCDAVAVLLSMRNPDGGFATYETKRGGHLLELLNpsevFGDI--MIDYTYVECTSAVMQALKYFHTHF 548
Cdd:TIGR01507 397 ----DERRRRDAMTKAFRWIAGMQSSNGGWGAFDVDNTSDLLNHIP----FCDFgaVTDPPTADVTARVLECLGSFGYDD 468
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 549 PdhraaeiRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtacAEVSRACDFLLSRQMADGG 628
Cdd:TIGR01507 469 A-------WPVIERAVEYLKREQEPDGSWFGRWGVNYLYGTGAVLSALKAVGIDTRE----PYIQKALAWLESHQNPDGG 537
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 629 WGEDFESCEERRYVQSAQSQIHNTCWALMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENISGV-FNKSCAISYTSY 707
Cdd:TIGR01507 538 WGEDCRSYEDPAYAGKGASTASQTAWALIALIAAGRAESEAARRGVQYLVETQRPDGGWDEPYYTGTgFPGDFYLGYHMY 617
|
650
....*....|....*
gi 635024088 708 RNVFPIWALGRFSQL 722
Cdd:TIGR01507 618 RHVFPLLALARYKQA 632
|
|
| ISOPREN_C2_like |
cd00688 |
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ... |
374-719 |
4.06e-56 |
|
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.
Pssm-ID: 238362 [Multi-domain] Cd Length: 300 Bit Score: 193.92 E-value: 4.06e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 374 DGMKMQGTNGSQIWDTAFAIQALLEAGGH--HRPEFSSCLQKAHEFLRLSQVPDnppdyqkyyrqmrkGGFSFSTLDcGW 451
Cdd:cd00688 15 DGHWYQSLCGEQTWSTAWPLLALLLLLAAtgIRDKADENIEKGIQRLLSYQLSD--------------GGFSGWGGN-DY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 452 IVADCTAEALKAVLLLQEkcpyvTEHIPRERLCDAVAVLLSMRNPDGGFATYEtkrgghllellnpsEVFGDIMIDYTYV 531
Cdd:cd00688 80 PSLWLTAYALKALLLAGD-----YIAVDRIDLARALNWLLSLQNEDGGFREDG--------------PGNHRIGGDESDV 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 532 ECTSAVMQALKYFHTHFPDhraaeirETLTQGLEFCRRQQRADGSWeGSWGVCFTYGTWFGLEAFACMGQTYRDgtacaE 611
Cdd:cd00688 141 RLTAYALIALALLGKLDPD-------PLIEKALDYLLSCQNYDGGF-GPGGESHGYGTACAAAALALLGDLDSP-----D 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 612 VSRACDFLLSRQMADGGWGedfesceERRYVQSAQSQIHNTCWALMGLMA-VRHPDIEAQERGVRCLLEKQLPNGDWPQE 690
Cdd:cd00688 208 AKKALRWLLSRQRPDGGWG-------EGRDRTNKLSDSCYTEWAAYALLAlGKLGDLEDAEKLVKWLLSQQNEDGGFSSK 280
|
330 340
....*....|....*....|....*....
gi 635024088 691 NIsgvfnkscaISYTSYRNVFPIWALGRF 719
Cdd:cd00688 281 PG---------KSYDTQHTVFALLALSLY 300
|
|
| SQHop_cyclase_C |
pfam13243 |
Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes ... |
384-719 |
2.54e-52 |
|
Squalene-hopene cyclase C-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes the cyclization of squalene into hopene in bacteria. This reaction is part of a cationic cyclization cascade, which is homologous to a key step in cholesterol biosynthesis. This family is the C-terminal half of the molecule.
Pssm-ID: 433057 [Multi-domain] Cd Length: 319 Bit Score: 184.08 E-value: 2.54e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 384 SQIWDTAFAIQALLEAGGhhrPEFSSCLQKAHEFLRLSQVPDnPPDYQKYYRQMRKGGFSFSTLDCGWIVADCTAealkA 463
Cdd:pfam13243 2 SPVWDTALALHALLEAGV---PADHPALVKAAQWLLDRQVLV-KGDWAVKRPDLEPGGWAFQFANDHYPDVDDTA----V 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 464 VLLLQEKCPYVTEHIPRERLCDAVAVLLSMRNPDGGFATYETKrggHLLELLN--PsevFGDI--MIDYTYVECTSAVMQ 539
Cdd:pfam13243 74 VVLALDRVRLPDERRRDDAIARGIEWILGMQSKNGGWGAFDKD---NTKYYLNkiP---FADHgaLLDPPTADVTARVLE 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 540 ALKYFHthFPDHRAAEIRetltqGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDgtacAEVSRACDFL 619
Cdd:pfam13243 148 MLGQLG--YPDDHPVAAR-----ALEYLKKEQEPDGSWFGRWGVNYIYGTWSVLCGLAAVGEDHNR----PYIRKAVDWL 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 620 LSRQMADGGWGEDFESCEERRYVQSAQSQIHNTCWALMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENISGV-FNK 698
Cdd:pfam13243 217 KSRQNPDGGWGEDCESYKDPKLAGRGPSTASQTAWALLALMAAGEVDSPAVRRGIQYLLETQKPDGTWDEPYFTGTgFPR 296
|
330 340
....*....|....*....|.
gi 635024088 699 SCAISYTSYRNVFPIWALGRF 719
Cdd:pfam13243 297 VFYLKYHGYRNYFPLWALARY 317
|
|
| SQHop_cyclase_N |
pfam13249 |
Squalene-hopene cyclase N-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes ... |
86-325 |
2.34e-40 |
|
Squalene-hopene cyclase N-terminal domain; Squalene-hopene cyclase, EC:5.4.99.17, catalyzes the cyclization of squalene into hopene in bacteria. This reaction is part of a cationic cyclization cascade, which is homologous to a key step in cholesterol biosynthesis. This family is the N-terminal domain.
Pssm-ID: 433061 [Multi-domain] Cd Length: 290 Bit Score: 149.94 E-value: 2.34e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 86 GLQAEDGHWTGD----------YggplfllpgllITCHVARIPLPAGYKEEIVRYLRSVQLPDGGWGLHIEDKSTVFGTA 155
Cdd:pfam13249 10 SLQHPDGHWVGEleanvtitaeY-----------ILLRHFLGPDDPELEAKIARYLRSQQREDGGWPLFHGGPGDLSTTV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 156 LNYVSLRILGVGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQ 235
Cdd:pfam13249 79 EAYFALKLLGDSPDAPHMVRAREFILARGGAAKANVFTRIWLALFGQYPWRGVPSMPPEIMLLPRWFPFNIYKFSSWART 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 236 VYLPMSYCYAIRLSATEDPlvQSLRQELYVEDFASIDWPAQRnnvapdelYTPHSW--LLHVVYALLNLYERHHSAHLRQ 313
Cdd:pfam13249 159 TIVPLLILSALKPVAPLPP--GIGLDELFVEPPENVRYYPRP--------HRLFSWtnLFLGLDRVLKLYERLPPKPLRR 228
|
250
....*....|..
gi 635024088 314 RAVQKLYEHIVA 325
Cdd:pfam13249 229 RALRKAEEWILE 240
|
|
| squa_tetra_cyc |
TIGR04277 |
squalene--tetrahymanol cyclase; This enzyme, also called squalene--tetrahymanol cyclase, ... |
131-719 |
2.36e-22 |
|
squalene--tetrahymanol cyclase; This enzyme, also called squalene--tetrahymanol cyclase, occurs a small number of eukaryotes, some of them anaerobic. The pathway can occur under anaerobic conditions, and the product is thought to replace sterols, letting organisms with this compound build membrane suitable for performing phagocytosis.
Pssm-ID: 212000 [Multi-domain] Cd Length: 624 Bit Score: 102.02 E-value: 2.36e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 131 LRSVQLPDGGWgLHIEDKSTVFG----TALNYVSLRILGVGPD-DPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSW 205
Cdd:TIGR04277 77 LLGSQFEDGSW-EQVEDANIETGqldaTIFNYWYLKAIGIDIHiDAALKKAQEWIKANGGIEAAQTMTKFKLAAFGQYPW 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 206 EGLntLFPEMWLFPDWAPAHPSTLWCHCRQ-VYLPMSYCYAIRLSATEDPLVQSLRQELYvedfasIDWPAQRNNVAPDE 284
Cdd:TIGR04277 156 EDL--FKIPLFIFKKKGIFKPLYIKDITAQwVYPHLTALAYLQNQRIIFNVAVADIRELW------INKAKKGIKHQKKE 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 285 LYT--PHSWLLHVVYALLNLyeRHHSAHLRQRAVQKLYEHIVADDrFTksisigpiSKTINMlvrwyvdgpastafqeHV 362
Cdd:TIGR04277 228 RPSffIDNDLLILMDEIFKL--KQPLGSFGAYTISTLLSLLAFKD-FQ--------GKHPHK----------------HK 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 363 SRIPDYLWMGLDGMKM------QGTNGS----QIWDTAFAIQALLEAGGHH---RPEFSSCLQKAHEflrlsqvPDNPPD 429
Cdd:TIGR04277 281 NEIQDALEDGLDFVEFnyfnfrEAYHGSlddgRWWDTILISWAMLESGEDKekiFPIVENMLKEGLQ-------PKGGIE 353
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 430 YQKYYrqmrkgGFSFSTLDCGwivadctaealkavLLLQEKCPYVTEHipRERLCDAVAVLLSMRNPDGGFATYET-KRG 508
Cdd:TIGR04277 354 YGYDF------EYAPDADDTG--------------LLLQVLSYYGEAF--ADAIDEGAEFLFSMQNDDGGFPAFDKgKME 411
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 509 GHLL--------------ELLNPS--EVFGDIM---IDYTYVECTSAVMQALKYFhthfpdhraaeiretltqglefcRR 569
Cdd:TIGR04277 412 DNLLfkfafkiagiadsaEIFDPScpDITAHILeglGEFGDQANHDQIQKMIKYF-----------------------MD 468
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 570 QQRADGSWEGSWGVCFTYGTWFGLEAFACMGQTYRDGTacaeVSRACDFLLSRQMADGGWGEDFESCEE-RRYVQSAQSQ 648
Cdd:TIGR04277 469 TQEKFGSWEARWGINYIMAAGAVLPALAKMNYDLNEGW----AKNAINWLLNKQNADGGFGECTLSYNDpEKWNGIGKST 544
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 635024088 649 IHNTCWALMGLMAVR-HPDI--EAQERGVRCLLEK-QLPNGDWPQENISGVFNKSCA-ISYTSYRNVFPIWALGRF 719
Cdd:TIGR04277 545 VTQTSWGLLALLAVEdHNDQikEAADKAAQYLLDQfKRDDGEFKDHSTIGTGHRGLLyLQYPSYAQSFPLIALGRF 620
|
|
| Prenyltrans |
pfam00432 |
Prenyltransferase and squalene oxidase repeat; |
124-165 |
7.11e-10 |
|
Prenyltransferase and squalene oxidase repeat;
Pssm-ID: 395346 [Multi-domain] Cd Length: 44 Bit Score: 54.82 E-value: 7.11e-10
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 635024088 124 KEEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVSLRILG 165
Cdd:pfam00432 3 KEKLVDYLLSCQNEDGGFGGRPGGESDTYYTYCALAALALLG 44
|
|
| CAL1 |
COG5029 |
Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, ... |
490-685 |
5.48e-08 |
|
Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, Lipid transport and metabolism];
Pssm-ID: 444045 [Multi-domain] Cd Length: 259 Bit Score: 54.71 E-value: 5.48e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 490 LLSMRNPDGGFATYETkrgghllellnPSEVFgdimidYTYVECTSAVMQALKYFHthfpDHRAAEIRETLtqglefcrr 569
Cdd:COG5029 28 LRASQNPDGGFAGRSG-----------PSDLY------STYYAVRTLALLGESPKW----RDRVADLLSSL--------- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 570 qQRADGSW----EGSWGvcFTYGTWFGLEAFACMGQTYRDgtacaeVSRACDFLLSRQMADGGWGEDFesceerryvqSA 645
Cdd:COG5029 78 -RVEDGGFakapEGGAG--STYHTYLATLLAELLGRPPPD------PDRLVRFLISQQNDDGGFEISP----------GR 138
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 635024088 646 QSQIHNTCWALMGLMAVRHPDIEAQERGVRCLLEKQLPNG 685
Cdd:COG5029 139 RSDTNPTAAAIGALRALGALDDPIETKVIRFLRDVQSPEG 178
|
|
| Prenyltrans |
pfam00432 |
Prenyltransferase and squalene oxidase repeat; |
564-600 |
3.71e-07 |
|
Prenyltransferase and squalene oxidase repeat;
Pssm-ID: 395346 [Multi-domain] Cd Length: 44 Bit Score: 47.12 E-value: 3.71e-07
10 20 30
....*....|....*....|....*....|....*...
gi 635024088 564 LEFCRRQQRADGSWEGSWGVC-FTYGTWFGLEAFACMG 600
Cdd:pfam00432 7 VDYLLSCQNEDGGFGGRPGGEsDTYYTYCALAALALLG 44
|
|
| Prenyltrans |
pfam00432 |
Prenyltransferase and squalene oxidase repeat; |
612-658 |
2.23e-06 |
|
Prenyltransferase and squalene oxidase repeat;
Pssm-ID: 395346 [Multi-domain] Cd Length: 44 Bit Score: 44.81 E-value: 2.23e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 635024088 612 VSRACDFLLSRQMADGGWGEDFESCeerryVQSAQSQIHNTCWALMG 658
Cdd:pfam00432 3 KEKLVDYLLSCQNEDGGFGGRPGGE-----SDTYYTYCALAALALLG 44
|
|
| CAL1 |
COG5029 |
Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, ... |
120-180 |
3.94e-06 |
|
Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, Lipid transport and metabolism];
Pssm-ID: 444045 [Multi-domain] Cd Length: 259 Bit Score: 48.93 E-value: 3.94e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 635024088 120 PAGYKEEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVSLRILGVGpDDPDLVRARNIL 180
Cdd:COG5029 111 PPPDPDRLVRFLISQQNDDGGFEISPGRRSDTNPTAAAIGALRALGAL-DDPIETKVIRFL 170
|
|
| AF1543 |
COG1689 |
Class II terpene cyclase family protein AF1543 [General function prediction only]; |
411-660 |
1.14e-03 |
|
Class II terpene cyclase family protein AF1543 [General function prediction only];
Pssm-ID: 441295 [Multi-domain] Cd Length: 272 Bit Score: 41.63 E-value: 1.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 411 LQKAHEFLRLSQVPDnppdyqkyyrqmrkGGFSF-----STLdcgwivADcTAEALKAVLLLQEKcpyvtehIPRERLCd 485
Cdd:COG1689 8 LARTIEYVLKRQNED--------------GGFCAypglpSTL------AD-TYYAVRILKLLGEE-------VPNRDKT- 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 486 aVAVLLSMRNPDGG-FATYETKRGGHLLELLnpsevfGDIMIDYtyvectsavMQALKYFHTHFPDHRAAE---IRET-- 559
Cdd:COG1689 59 -IEFLESCQDEEGGgFALYTTSYGLMALALL------GIDPPDE---------QEALEYLSDALPTKFAGGasdLEETyl 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 560 LTQGLE--------------FCRRQQRADGSWEGSWGVcfTYGTWFGLEAFACMGQTYRDGtacaevSRACDFLLSRQMA 625
Cdd:COG1689 123 AVALLEalgaseperekireFLLSLRRPDGGFGGKKPN--LEDTYWALAALRRLGRDLPPA------DRVIAFILACQNE 194
|
250 260 270
....*....|....*....|....*....|....*
gi 635024088 626 DGGWGedfesceerrYVQSAQSQIHNTCWALMGLM 660
Cdd:COG1689 195 DGGFS----------KTPGSYSDLEATYYALRALK 219
|
|
| CAL1 |
COG5029 |
Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, ... |
380-641 |
2.44e-03 |
|
Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, Lipid transport and metabolism];
Pssm-ID: 444045 [Multi-domain] Cd Length: 259 Bit Score: 40.46 E-value: 2.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 380 GTNG-SQIWDTAFAIQALLEAGGHHRPEFSSClqkahEFLRLSQVPDnppdyqkyyrqmrkGGFSfSTLDCGwivADCTA 458
Cdd:COG5029 40 GRSGpSDLYSTYYAVRTLALLGESPKWRDRVA-----DLLSSLRVED--------------GGFA-KAPEGG---AGSTY 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 459 EALKAVLLLQekcpyVTEhIPRERLCDAVAVLLSMRNPDGGFATYETKRGGhllelLNPsevfgdimidyTYveCTSAVM 538
Cdd:COG5029 97 HTYLATLLAE-----LLG-RPPPDPDRLVRFLISQQNDDGGFEISPGRRSD-----TNP-----------TA--AAIGAL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 539 QALKYFHthfPDHRAAEIRetltqgleFCRRQQRADGSwegswgvcFTYGTWFGleaFACMGQTYRDGTACAE------- 611
Cdd:COG5029 153 RALGALD---DPIETKVIR--------FLRDVQSPEGG--------FAYNTRIG---EADLLSTFTAILTLYDlgaapkl 210
|
250 260 270
....*....|....*....|....*....|.
gi 635024088 612 VSRACDFLLSRQMADGGW-GEDFESCEERRY 641
Cdd:COG5029 211 VDDLQAYILSLQLPDGGFeGAPWDGVEDVEY 241
|
|
| AF1543 |
COG1689 |
Class II terpene cyclase family protein AF1543 [General function prediction only]; |
380-501 |
2.98e-03 |
|
Class II terpene cyclase family protein AF1543 [General function prediction only];
Pssm-ID: 441295 [Multi-domain] Cd Length: 272 Bit Score: 40.09 E-value: 2.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 380 GTNGSQIWDTAFAIQALLEAGGHHRPEfssclQKAHEFLRLSQVPDnppdyqkyyrqmrkGGFSFSTLDCGWIvaDCTAE 459
Cdd:COG1689 155 GGKKPNLEDTYWALAALRRLGRDLPPA-----DRVIAFILACQNED--------------GGFSKTPGSYSDL--EATYY 213
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 635024088 460 ALKAVLLLQEKCPYVTEHIprerlcdavAVLLSMRNPDGGFA 501
Cdd:COG1689 214 ALRALKLLGEPPKNVDKLL---------EFIASCQNSDGGFR 246
|
|
| SQCY |
cd02889 |
Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - ... |
614-687 |
4.17e-03 |
|
Squalene cyclase (SQCY) domain; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. Bacterial SQCY catalyzes the convertion of squalene to hopene or diplopterol. Eukaryotic OSQCY transforms the 2,3-epoxide of squalene to compounds such as, lanosterol (a metabolic precursor of cholesterol and steroid hormones) in mammals and fungi or, cycloartenol in plants. Deletion of a single glycine residue of Alicyclobacillus acidocaldarius SQCY alters its substrate specificity into that of eukaryotic OSQCY. Both enzymes have a second minor domain, which forms an alpha-alpha barrel that is inserted into the major domain. This group also contains SQCY-like archael sequences and some bacterial SQCY's which lack this minor domain.
Pssm-ID: 239219 [Multi-domain] Cd Length: 348 Bit Score: 39.90 E-value: 4.17e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 635024088 614 RACDFLLSRQMADGGWGEDFesceerryvqsaqSQIHNTCWALMGLMA--VRHPDIEAQERGVRCLLEKQLP-NGDW 687
Cdd:cd02889 3 RALDFLLSLQAPDGHWPGEY-------------SQVWDTALALQALLEagLAPEFDPALKKALEWLLKSQIRdNPDD 66
|
|
| CAL1 |
COG5029 |
Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, ... |
372-500 |
4.90e-03 |
|
Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, Lipid transport and metabolism];
Pssm-ID: 444045 [Multi-domain] Cd Length: 259 Bit Score: 39.30 E-value: 4.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635024088 372 GLDGMKMQGTNgsqiwDTAFAIQALLEAGGHHRPEFSSCLQkaheFLRLSQVPDnppdyqkyyrqmrkGGFSFSTldcgW 451
Cdd:COG5029 133 EISPGRRSDTN-----PTAAAIGALRALGALDDPIETKVIR----FLRDVQSPE--------------GGFAYNT----R 185
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 635024088 452 IVADCTAEALKAVLLLQEkcpyvTEHIPRERlCDAVAVLLSMRNPDGGF 500
Cdd:COG5029 186 IGEADLLSTFTAILTLYD-----LGAAPKLV-DDLQAYILSLQLPDGGF 228
|
|
| |
