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Conserved domains on  [gi|1049400014|ref|XP_008629890|]
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PREDICTED: protein Wnt-11 isoform X1 [Corvus brachyrhynchos]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Wnt_Wnt11 cd19343
Wnt domain found in protein Wnt-11 and similar proteins; Wnt-11 may be a signaling molecule ...
 103-406 0e+00

Wnt domain found in protein Wnt-11 and similar proteins; Wnt-11 may be a signaling molecule which has possible roles in the development of skeleton, kidney and lung. It is a positive regulator of the Wnt signaling pathway, which plays a crucial role in carcinogenesis. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


:

Pssm-ID: 381717  Cd Length: 305  Bit Score: 555.71  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 103 LVVSQVQLCRSNLELMQTIIQAAQEVIKTCRKTFSDMRWNCSSIELAPNYLLDLERGTRESAFVYALSAAAISHTIARAC 182
Cdd:cd19343     1 LVGDQVKLCRRNLELMPSVVEAARLTVDTCQEQFADRRWNCSSIELAPNFTPDLTRGTREQAFVYALSSAALTHTIARAC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 183 TTGDLPGCSCGPIPGETPGPGYRWGGCADNLNYGLIMGSKFSDAPMKMKK-SGSQANKLMHLHNSEVGRQVLKASLEMKC 261
Cdd:cd19343    81 ASGALPGCGCGRLPREPPDGDFKWGGCGDNVRYGLRFAKRFTDAPEKKKKkKKRQARALMNLHNNRVGRKAVRDSLETQC 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 262 KCHGVSGSCSIKTCWKGLQELQDIALDLKNKYLSATKVVHRPMGTRKYLVPKDIDIRPVKETELIYLQSSPDFCMKNEKV 341
Cdd:cd19343   161 KCHGVSGSCSVKTCWKALPDLSEVASRLKRKYARAVEVVSRKVGSRRKLVPKSLKVRPYTKDDLIYLTKSPDYCLPDEKL 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1049400014 342 GSHGTQDRQCNKTSNGSDSCDLMCCGRGYNPYMDKVVERCHCKYHWCCYVTCKKCERTVERYVCK 406
Cdd:cd19343   241 GSLGTRGRECNKTSVGSDSCDSMCCGRGYRTYTVEVVERCHCKYHWCCYVKCKTCRRTVEVHVCK 305
 
Name Accession Description Interval E-value
Wnt_Wnt11 cd19343
Wnt domain found in protein Wnt-11 and similar proteins; Wnt-11 may be a signaling molecule ...
 103-406 0e+00

Wnt domain found in protein Wnt-11 and similar proteins; Wnt-11 may be a signaling molecule which has possible roles in the development of skeleton, kidney and lung. It is a positive regulator of the Wnt signaling pathway, which plays a crucial role in carcinogenesis. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381717  Cd Length: 305  Bit Score: 555.71  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 103 LVVSQVQLCRSNLELMQTIIQAAQEVIKTCRKTFSDMRWNCSSIELAPNYLLDLERGTRESAFVYALSAAAISHTIARAC 182
Cdd:cd19343     1 LVGDQVKLCRRNLELMPSVVEAARLTVDTCQEQFADRRWNCSSIELAPNFTPDLTRGTREQAFVYALSSAALTHTIARAC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 183 TTGDLPGCSCGPIPGETPGPGYRWGGCADNLNYGLIMGSKFSDAPMKMKK-SGSQANKLMHLHNSEVGRQVLKASLEMKC 261
Cdd:cd19343    81 ASGALPGCGCGRLPREPPDGDFKWGGCGDNVRYGLRFAKRFTDAPEKKKKkKKRQARALMNLHNNRVGRKAVRDSLETQC 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 262 KCHGVSGSCSIKTCWKGLQELQDIALDLKNKYLSATKVVHRPMGTRKYLVPKDIDIRPVKETELIYLQSSPDFCMKNEKV 341
Cdd:cd19343   161 KCHGVSGSCSVKTCWKALPDLSEVASRLKRKYARAVEVVSRKVGSRRKLVPKSLKVRPYTKDDLIYLTKSPDYCLPDEKL 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1049400014 342 GSHGTQDRQCNKTSNGSDSCDLMCCGRGYNPYMDKVVERCHCKYHWCCYVTCKKCERTVERYVCK 406
Cdd:cd19343   241 GSLGTRGRECNKTSVGSDSCDSMCCGRGYRTYTVEVVERCHCKYHWCCYVKCKTCRRTVEVHVCK 305
WNT1 smart00097
found in Wnt-1;
99-406 1.53e-165

found in Wnt-1;


Pssm-ID: 128408  Cd Length: 305  Bit Score: 466.03  E-value: 1.53e-165
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014   99 QLEGLVVSQVQLCRSNLELMQTIIQAAQEVIKTCRKTFSDMRWNCSSIELAPNYLLDLERGTRESAFVYALSAAAISHTI 178
Cdd:smart00097   1 SLPGLSRRQRRLCRANPDVMISVAEGAQEGIEECQHQFRFRRWNCSTLDNASVFGKVLRQGTRETAFVYAISSAGVAHAV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014  179 ARACTTGDLPGCSCGPIP-GETPGPGYRWGGCADNLNYGLIMGSKFSDAPMKmkksGSQANKLMHLHNSEVGRQVLKASL 257
Cdd:smart00097  81 TRACSEGELDSCGCDYRKrGRAGGRGWKWGGCSDNIDFGIRFSREFVDARER----GKDARALMNLHNNEAGRLAVKKTM 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014  258 EMKCKCHGVSGSCSIKTCWKGLQELQDIALDLKNKYLSATKVVHRPMGTRKYLVPKDIDIRPVKETELIYLQSSPDFCMK 337
Cdd:smart00097 157 KRECKCHGVSGSCTVKTCWLQLPDFRKVGDYLKEKYDGASEVEVDKRGTNKAPVPKNSTFKPPTETDLVYLESSPDFCEK 236

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1049400014  338 NEKVGSHGTQDRQCNKTSNGSDSCDLMCCGRGYNPYMDKVVERCHCKYHWCCYVTCKKCERTVERYVCK 406
Cdd:smart00097 237 NPKTGSLGTQGRQCNKTSKGLDGCDLLCCGRGYNTRTVEVVERCNCKFHWCCYVKCKQCRETVEKHTCK 305
wnt pfam00110
wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, ...
 99-406 4.84e-156

wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.


Pssm-ID: 459677  Cd Length: 307  Bit Score: 441.99  E-value: 4.84e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014  99 QLEGLVVSQVQLCRSNLELMQTIIQAAQEVIKTCRKTFSDMRWNCSSIELAPNYLL-DLERGTRESAFVYALSAAAISHT 177
Cdd:pfam00110   1 KLPGLSPRQRRLCRRNPDVMASVAEGAQLAIEECQHQFRNRRWNCSTLENKRPVFGkVLKRGTRETAFVYAISSAGVTHA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 178 IARACTTGDLPGCSCGPIPGE--TPGPGYRWGGCADNLNYGLIMGSKFSDAPMKmkkSGSQANKLMHLHNSEVGRQVLKA 255
Cdd:pfam00110  81 VTRACSSGELTSCGCDRKKRGksSGEGGWEWGGCSDNIDYGYKFSRKFVDAREK---KRRDARALMNLHNNEAGRKAVKS 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 256 SLEMKCKCHGVSGSCSIKTCWKGLQELQDIALDLKNKYLSATKVvHRPMGTRKYLVPKDIDIRPVKETELIYLQSSPDFC 335
Cdd:pfam00110 158 NMRTECKCHGVSGSCSVKTCWKALPPFREVGDRLKEKYDGAVKV-NRRRNKRGRLVPRNSRFKPPTKNDLVYLEKSPDYC 236

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1049400014 336 MKNEKVGSHGTQDRQCNKTSNGSDSCDLMCCGRGYNPYMDKVVERCHCKYHWCCYVTCKKCERTVERYVCK 406
Cdd:pfam00110 237 ERNPKTGSLGTRGRECNKTSSGPDGCDLLCCGRGYNTRTVTVTERCNCKFHWCCYVKCKTCTETVEVYTCK 307
 
Name Accession Description Interval E-value
Wnt_Wnt11 cd19343
Wnt domain found in protein Wnt-11 and similar proteins; Wnt-11 may be a signaling molecule ...
 103-406 0e+00

Wnt domain found in protein Wnt-11 and similar proteins; Wnt-11 may be a signaling molecule which has possible roles in the development of skeleton, kidney and lung. It is a positive regulator of the Wnt signaling pathway, which plays a crucial role in carcinogenesis. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381717  Cd Length: 305  Bit Score: 555.71  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 103 LVVSQVQLCRSNLELMQTIIQAAQEVIKTCRKTFSDMRWNCSSIELAPNYLLDLERGTRESAFVYALSAAAISHTIARAC 182
Cdd:cd19343     1 LVGDQVKLCRRNLELMPSVVEAARLTVDTCQEQFADRRWNCSSIELAPNFTPDLTRGTREQAFVYALSSAALTHTIARAC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 183 TTGDLPGCSCGPIPGETPGPGYRWGGCADNLNYGLIMGSKFSDAPMKMKK-SGSQANKLMHLHNSEVGRQVLKASLEMKC 261
Cdd:cd19343    81 ASGALPGCGCGRLPREPPDGDFKWGGCGDNVRYGLRFAKRFTDAPEKKKKkKKRQARALMNLHNNRVGRKAVRDSLETQC 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 262 KCHGVSGSCSIKTCWKGLQELQDIALDLKNKYLSATKVVHRPMGTRKYLVPKDIDIRPVKETELIYLQSSPDFCMKNEKV 341
Cdd:cd19343   161 KCHGVSGSCSVKTCWKALPDLSEVASRLKRKYARAVEVVSRKVGSRRKLVPKSLKVRPYTKDDLIYLTKSPDYCLPDEKL 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1049400014 342 GSHGTQDRQCNKTSNGSDSCDLMCCGRGYNPYMDKVVERCHCKYHWCCYVTCKKCERTVERYVCK 406
Cdd:cd19343   241 GSLGTRGRECNKTSVGSDSCDSMCCGRGYRTYTVEVVERCHCKYHWCCYVKCKTCRRTVEVHVCK 305
WNT1 smart00097
found in Wnt-1;
99-406 1.53e-165

found in Wnt-1;


Pssm-ID: 128408  Cd Length: 305  Bit Score: 466.03  E-value: 1.53e-165
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014   99 QLEGLVVSQVQLCRSNLELMQTIIQAAQEVIKTCRKTFSDMRWNCSSIELAPNYLLDLERGTRESAFVYALSAAAISHTI 178
Cdd:smart00097   1 SLPGLSRRQRRLCRANPDVMISVAEGAQEGIEECQHQFRFRRWNCSTLDNASVFGKVLRQGTRETAFVYAISSAGVAHAV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014  179 ARACTTGDLPGCSCGPIP-GETPGPGYRWGGCADNLNYGLIMGSKFSDAPMKmkksGSQANKLMHLHNSEVGRQVLKASL 257
Cdd:smart00097  81 TRACSEGELDSCGCDYRKrGRAGGRGWKWGGCSDNIDFGIRFSREFVDARER----GKDARALMNLHNNEAGRLAVKKTM 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014  258 EMKCKCHGVSGSCSIKTCWKGLQELQDIALDLKNKYLSATKVVHRPMGTRKYLVPKDIDIRPVKETELIYLQSSPDFCMK 337
Cdd:smart00097 157 KRECKCHGVSGSCTVKTCWLQLPDFRKVGDYLKEKYDGASEVEVDKRGTNKAPVPKNSTFKPPTETDLVYLESSPDFCEK 236

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1049400014  338 NEKVGSHGTQDRQCNKTSNGSDSCDLMCCGRGYNPYMDKVVERCHCKYHWCCYVTCKKCERTVERYVCK 406
Cdd:smart00097 237 NPKTGSLGTQGRQCNKTSKGLDGCDLLCCGRGYNTRTVEVVERCNCKFHWCCYVKCKQCRETVEKHTCK 305
wnt pfam00110
wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, ...
 99-406 4.84e-156

wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.


Pssm-ID: 459677  Cd Length: 307  Bit Score: 441.99  E-value: 4.84e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014  99 QLEGLVVSQVQLCRSNLELMQTIIQAAQEVIKTCRKTFSDMRWNCSSIELAPNYLL-DLERGTRESAFVYALSAAAISHT 177
Cdd:pfam00110   1 KLPGLSPRQRRLCRRNPDVMASVAEGAQLAIEECQHQFRNRRWNCSTLENKRPVFGkVLKRGTRETAFVYAISSAGVTHA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 178 IARACTTGDLPGCSCGPIPGE--TPGPGYRWGGCADNLNYGLIMGSKFSDAPMKmkkSGSQANKLMHLHNSEVGRQVLKA 255
Cdd:pfam00110  81 VTRACSSGELTSCGCDRKKRGksSGEGGWEWGGCSDNIDYGYKFSRKFVDAREK---KRRDARALMNLHNNEAGRKAVKS 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 256 SLEMKCKCHGVSGSCSIKTCWKGLQELQDIALDLKNKYLSATKVvHRPMGTRKYLVPKDIDIRPVKETELIYLQSSPDFC 335
Cdd:pfam00110 158 NMRTECKCHGVSGSCSVKTCWKALPPFREVGDRLKEKYDGAVKV-NRRRNKRGRLVPRNSRFKPPTKNDLVYLEKSPDYC 236

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1049400014 336 MKNEKVGSHGTQDRQCNKTSNGSDSCDLMCCGRGYNPYMDKVVERCHCKYHWCCYVTCKKCERTVERYVCK 406
Cdd:pfam00110 237 ERNPKTGSLGTRGRECNKTSSGPDGCDLLCCGRGYNTRTVTVTERCNCKFHWCCYVKCKTCTETVEVYTCK 307
Wnt cd13113
Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary ...
 117-405 7.75e-135

Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family; Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about the structure of Wnt proteins, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. Wnt signaling mediated by Wnt proteins orchestrates and influences a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381706  Cd Length: 288  Bit Score: 387.80  E-value: 7.75e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 117 LMQTIIQAAQEVIKTCRKTFSDMRWNCSSIELAPNYLLDLERGTRESAFVYALSAAAISHTIARACTTGDLPGCSCG-PI 195
Cdd:cd13113     1 LMESIAEGAQLALKECQRQFANRRWNCSTFNEPLLFGKILKRGTRETAFVHAITSAGVTHAITRACSRGKLKNCGCDrTR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 196 PGETPGPGYRWGGCADNLNYGLIMGSKFSDApmKMKKSGSQANKLMHLHNSEVGRQVLKASLEMKCKCHGVSGSCSIKTC 275
Cdd:cd13113    81 QGPEGQGDWTWGGCSDNIKFGIKFSRKFLDA--REKKKGSDARSLMNLHNNEAGRKAVKKTMKKKCKCHGVSGSCTTKTC 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 276 WKGLQELQDIALDLKNKYLSATKVVHRPMGTRKYLVPKDIDIRPVKETELIYLQSSPDFCMKNEKVGSHGTQDRQCNKTS 355
Cdd:cd13113   159 WRQLPSFREIGDYLKEKYDNAVKVKLNNNGSGLRLVPKRSRFRSPTETDLVYLEESPDYCEPNPTLGSLGTAGRECNPTS 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1049400014 356 NGSDSCDLMCCGRGYNPYMDKVVERCHCKYHWCCYVTCKKCERTVERYVC 405
Cdd:cd13113   239 PGPDSCELLCCGRGYRTETEIVTEKCNCKFVWCCEVKCETCRRTVERYTC 288
Wnt_Wnt4 cd19336
Wnt domain found in protein Wnt-4 and similar proteins; Wnt-4 may function as a signaling ...
 97-406 3.16e-123

Wnt domain found in protein Wnt-4 and similar proteins; Wnt-4 may function as a signaling molecule which affects the development of discrete regions of tissues. Its overexpression may be associated with abnormal proliferation in human breast tissue. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381710  Cd Length: 310  Bit Score: 358.94  E-value: 3.16e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014  97 CKQLEGLVVSQVQLCRSNLELMQTIIQAAQEVIKTCRKTFSDMRWNCSSIELAPNYLLDLERGTRESAFVYALSAAAISH 176
Cdd:cd19336     1 CESLKGLTKRQVQFCKRNLEVMDSVRRGAQLAIEECQFQFRNRRWNCSTLDKEPVFGKVLNQGTREAAFVHAISSAGVAH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 177 TIARACTTGDLPGCSCG-PIPGETPgPGYRWGGCADNLNYGLIMGSKFSDAPMKMKKSGSQANKLMHLHNSEVGRQVLKA 255
Cdd:cd19336    81 AVTRACSSGELEKCGCDrSVRGRSP-EGFQWSGCSDNVAYGVAFSKSFVDARERRKGRASSSRALMNLHNNEAGRKAIEK 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 256 SLEMKCKCHGVSGSCSIKTCWKGLQELQDIALDLKNKYLSATKVVHRPMGTRKYLVPKDIDIRPVKETELIYLQSSPDFC 335
Cdd:cd19336   160 NMRVECKCHGVSGSCELKTCWRAMPTFREVGNILKEKFDGATEVQQKRIGSRPVLVPKNPQFKPHTDADLVYLDSSPDFC 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1049400014 336 MKNEKVGSHGTQDRQCNKTSNGSDSCDLMCCGRGYNPYMDKVVERCHCKYHWCCYVTCKKCERTVERYVCK 406
Cdd:cd19336   240 EPDPKTGSLGTHGRVCNKTSKAIDGCDLLCCGRGYVTRTEEVVERCSCKFHWCCYVKCKTCRREVEVHTCR 310
Wnt_Wnt16 cd19344
Wnt domain found in protein Wnt-16 and similar proteins; Wnt-16 is a mixed canonical and ...
 103-406 1.13e-115

Wnt domain found in protein Wnt-16 and similar proteins; Wnt-16 is a mixed canonical and noncanonical Wnt ligand involved in the regulation of postnatal bone homeostasis. It promotes bone formation and inhibits bone resorption. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381718  Cd Length: 306  Bit Score: 339.59  E-value: 1.13e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 103 LVVSQVQLCRSNLELMQTIIQAAQEVIKTCRKTFSDMRWNCSSIELAPNYLLDLERGTRESAFVYALSAAAISHTIARAC 182
Cdd:cd19344     1 LVSQQRRLCKKKPEAIPSVSEGARLGIYECQHQFRHERWNCSTTNDQNVFGKTLSRGTKETAFIYAITSAGVVHAVTRAC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 183 TTGDLPGCSCGPIPGETPGP-GYRWGGCADNLNYGLIMGSKFSDAPMK-MKKSGSQANKLMHLHNSEVGRQVLKASLEMK 260
Cdd:cd19344    81 SAGNLTDCSCDSRRQGQSASeGWKWGGCSDNVDYGIWFARKFVDAPEKsERKRSRDVRSLMNLHNNEVGRQAIARLMKVK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 261 CKCHGVSGSCSIKTCWKGLQELQDIALDLKNKYLSATKVVHRPmgTRKYLVPKDIDIR--PVKETELIYLQSSPDFCMKN 338
Cdd:cd19344   161 CRCHGVSGSCEVKTCWKTMPSFEEVGDFLKQKYENSIQIATKK--SKRRLRRRERRKRkvPISKDELVYIHKSPNYCVRD 238

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1049400014 339 EKVGSHGTQDRQCNKTSNGSDSCDLMCCGRGYNPYMDKVVERCHCKYHWCCYVTCKKCERTVERYVCK 406
Cdd:cd19344   239 PKKGILGTSGRECNRTSTGPDSCDLLCCGRGYNTQVVRHVERCNCKFVWCCYVKCKTCETMTDVHTCK 306
Wnt_Wnt6 cd19338
Wnt domain found in protein Wnt-6 and similar proteins; Wnt-6 may function as a signaling ...
 91-406 1.88e-114

Wnt domain found in protein Wnt-6 and similar proteins; Wnt-6 may function as a signaling molecule which affects the development of discrete regions of tissues. It may promote tumorigenesis in gastrointestinal cancer and cervical cancer. It can compensate for the absence of ectoderm and can induce the formation of muscle cells in the limb. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381712  Cd Length: 310  Bit Score: 336.50  E-value: 1.88e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014  91 LNQTQHCKQLEGLVVSQVQLCRSNLELMQTIIQAAQEVIKTCRKTFSDMRWNCSSIelaPNYLLD-LERGTRESAFVYAL 169
Cdd:cd19338     1 MDPNSICRKTRRLKGKQREICRKEPEILEEVAKGAKLGIRECQYQFRNRRWNCSTS---RKSFGKiLKRDTRETAFVYAI 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 170 SAAAISHTIARACTTGDLPGCSCGPIPGETPGPG-YRWGGCADNLNYGLIMGSKFSDAPMKMKKSGSqanKLMHLHNSEV 248
Cdd:cd19338    78 TSAGVTYSVTRACSMGELLQCGCDKSKRGKSTEGeWEWGGCSDNVRYGYRKSREFMDAKEKNRSDIR---TLMNLHNNEA 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 249 GRQVLKASLEMKCKCHGVSGSCSIKTCWKGLQELQDIALDLKNKYLSATKVvhRPMGTRKYLVPKDIDIRPVKETELIYL 328
Cdd:cd19338   155 GRLAVKNNMRKECKCHGLSGSCTLKTCWRKMPPFREVGDRLKERFDGAIKV--KGSNDGKSLIPEGKTIKPPTKEDLVYL 232

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1049400014 329 QSSPDFCMKNEKVGSHGTQDRQCNKTSNGSDSCDLMCCGRGYNPYMDKVVERCHCKYHWCCYVTCKKCERTVERYVCK 406
Cdd:cd19338   233 EESPDFCEPNKKTGSLGTRGRECNRTSMGVDGCDLLCCGRGYQTEVRVVEENCNCRFHWCCEVKCETCKVRKEIHTCN 310
Wnt_Wnt5 cd19337
Wnt domain found in protein Wnt-5a, Wnt-5b and similar proteins; The family includes Wnt-5a ...
 97-406 7.29e-113

Wnt domain found in protein Wnt-5a, Wnt-5b and similar proteins; The family includes Wnt-5a and Wnt-5b, both of which are secreted growth factors that belong to the noncanonical members of the Wingless-related MMTV-integration family. Wnt-5a can activate or inhibit canonical Wnt signaling, depending on receptor context. It specifically regulates dendritic spine formation in rodent hippocampal neurons, resulting in postsynaptic development that promotes the clustering of the postsynaptic density protein 95 (PSD-95). The overexpression of Wnt-5b is associated with cancer aggressiveness. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381711  Cd Length: 313  Bit Score: 332.67  E-value: 7.29e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014  97 CKQLEGLVVSQVQLCRSNLELMQTIIQAAQEVIKTCRKTFSDMRWNCSSIELAPNYLLDLERGTRESAFVYALSAAAISH 176
Cdd:cd19337     1 CDQLRGLSPGQRKLCQLYQDHMPSVGRGAKLAIEECQYQFRYRRWNCSTPDSSSVFGPVTNIGTREAAFTYAISAAGVVH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 177 TIARACTTGDLPGCSCGPIPGETPGP-GYRWGGCADNLNYGLIMGSKFSDAPMKMK--KSGSQ--ANKLMHLHNSEVGRQ 251
Cdd:cd19337    81 AIARACREGNLSTCGCSRERRPKDLPrDWLWGGCGDNIEYGYKFAKEFIDARERETnyPRHSRelARVLMNLHNNEAGRR 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 252 VLKASLEMKCKCHGVSGSCSIKTCWKGLQELQDIALDLKNKYLSATKVVHRPMGTRKyLVPKDIDIRPVKEtELIYLQSS 331
Cdd:cd19337   161 AVYEKARVACKCHGVSGSCSLKTCWRQLAPFREVGDRLKDKYDGAVKVKLNRRGTLL-RRRNSRFNKPTKD-DLVYLDDS 238

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1049400014 332 PDFCMKNEKVGSHGTQDRQCNKTSNGSDSCDLMCCGRGYNPYMDKVVERCHCKYHWCCYVTCKKCERTVERYVCK 406
Cdd:cd19337   239 PDYCERNPKTGSLGTKGRECNKTSSGTDGCELLCCGRGYNTKKVEVVERCHCKFHWCCEVKCKTCEKIVDVHICK 313
Wnt_Wnt3_Wnt3a cd19335
Wnt domain found in proto-oncogene Wnt-3 and similar proteins; Wnt-3, also called ...
 97-406 4.39e-111

Wnt domain found in proto-oncogene Wnt-3 and similar proteins; Wnt-3, also called proto-oncogene Int-4, functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It is required for normal embryonic development, and especially for limb development. Wnt-3a functions in the canonical Wnt signaling pathway and plays crucial roles in both proliferation and differentiation processes in several types of stem cells. Wnt3a stimulates the migration and invasion of trophoblasts and induce the survival, proliferation, and migration of human embryonic kidney (HEK) 293 cells. It also up-regulates genes implicated in melanocyte differentiation and increases the expression and nuclear localization of the transcriptional co-activator with PDZ-binding motif (TAZ), a transcriptional modulator involved in activating osteoblastic differentiation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381709  Cd Length: 314  Bit Score: 328.20  E-value: 4.39e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014  97 CKQLEGLVVSQVQLCRSNLELMQTIIQAAQEVIKTCRKTFSDMRWNCSSIELAPNYLLD-LERGTRESAFVYALSAAAIS 175
Cdd:cd19335     4 CGSIPGLVPKQLRFCRNYTELMPSVAEGAKLGIQECQHQFRGRRWNCTTIEGDLSVFGPvLDKASRESAFVHAIASAGVA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 176 HTIARACTTGDLPGCSCGPIPGETPGPGYRWGGCADNLNYGLIMGSKFSDAPMKMKKsgsqANKLMHLHNSEVGRQVLKA 255
Cdd:cd19335    84 HAVTRACAEGDSTSCGCDSRHKGPPGEGWRWGGCSEDVEFGVRFSREFADARENRPD----ARSAMNRHNNEAGRQAILD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 256 SLEMKCKCHGVSGSCSIKTCWKGLQELQDIALDLKNKYLSATK-VVHRPMGTRKY---LVPKDIDIRPVKETELIYLQSS 331
Cdd:cd19335   160 NMELKCKCHGLSGSCELKTCWWAQPDFRKIGDYLKDKYDSASEmVVERHRESRGWvetLRPKYKLFKPPTERDLIYYEES 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1049400014 332 PDFCMKNEKVGSHGTQDRQCNKTSNGSDSCDLMCCGRGYNPYMDKVVERCHCKYHWCCYVTCKKCERTVERYVCK 406
Cdd:cd19335   240 PNFCEPNPETGSFGTRGRECNVTSHGIDGCDLLCCGRGYNTRTEKRTEKCHCIFVWCCYVSCQECIRVYDVHTCK 314
Wnt_Wnt2_like cd19334
Wnt domain found in protein Wnt-2, Wnt-2b and similar proteins; The family includes Wnt-2 and ...
 97-406 6.89e-108

Wnt domain found in protein Wnt-2, Wnt-2b and similar proteins; The family includes Wnt-2 and Wnt-2b. Wnt-2, also called Int-1-like protein 1 (INT1L1), or Int-1-related protein (IRP), functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It plays an important role in embryonic lung development. Wnt-2b, also called protein Wnt-13, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a redundant role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381708  Cd Length: 314  Bit Score: 320.05  E-value: 6.89e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014  97 CKQLEGLVVSQVQLCRSNLELMQTIIQAAQEVIKTCRKTFSDMRWNCSSIELAPNYLLD-LERGTRESAFVYALSAAAIS 175
Cdd:cd19334     6 CDNIPGLVSKQRQLCRKHPDVMVSIGEGAKLGVKECQYQFRNQRWNCSTVDRDATVFGKvLLKGSREAAFVYAISSAGVV 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 176 HTIARACTTGDLPGCSCGPIP---GETPGPGYRWGGCADNLNYGLIMGSKFSDApmkMKKSGSQANKLMHLHNSEVGRQV 252
Cdd:cd19334    86 HAITRACSKGELLNCACDPTKrgkGRDSKGEFDWGGCSDNVKYGINFARKFVDA---RERRVRDARALMNLHNNRAGRKA 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 253 LKASLEMKCKCHGVSGSCSIKTCWKGLQELQDIALDLKNKYLSATKVVHRPMGTRkyLVPKDIDIRPVKETELIYLQSSP 332
Cdd:cd19334   163 VKKNLKLQCKCHGVSGSCTIRTCWRALAEFREVGDYLREKYDGAVQVTMNQSGTN--LLAANKGHKKPTRSDLVYFESSP 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1049400014 333 DFCMKNEKVGSHGTQDRQCNKTSNGSDSCDLMCCGRGYNPYMDKVVERCHCKYHWCCYVTCKKCERTVERYVCK 406
Cdd:cd19334   241 DYCVPNPETGSLGTAGRVCNKTSTGTDGCDIMCCGRGYDTTRVRRTTKCNCKFHWCCQVKCKTCTETVDVHTCK 314
Wnt_Wnt10 cd19342
Wnt domain found in protein Wnt-10a, Wnt-10b and similar proteins; The family includes protein ...
 97-406 4.37e-106

Wnt domain found in protein Wnt-10a, Wnt-10b and similar proteins; The family includes protein Wnt-10a and Wnt-10b. Wnt-10a plays a role in normal ectoderm development. It is required for normal postnatal development and maintenance of tongue papillae and sweat ducts, as well as normal hair follicle function. Wnt-10b, also called protein Wnt-12, specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. It is involved in signaling networks controlling stemness, pluripotency, and cell fate decisions. Wnt-10b is unique and plays an important role in differentiation of epithelial cells in the hair follicle. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381716  Cd Length: 316  Bit Score: 315.74  E-value: 4.37e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014  97 CKQLEGLVVSQVQLCRSNLELMQTIIQAAQEVIKTCRKTFSDMRWNCSSIELAPNYLLD---LERGTRESAFVYALSAAA 173
Cdd:cd19342     4 CRTFPGLTREQLELCRRYPDVTASAIQGIQLAVHECQRQFRDHRWNCSSLETKNKNPHTspiLSRGYRETAFAYAISAAG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 174 ISHTIARACTTGDLPGCSCGPIPGETPGPG--YRWGGCADNLNYGLIMGSKFSDApmkmKKSGSQANKLMHLHNSEVGRQ 251
Cdd:cd19342    84 VAHQVARACSLGKLLSCGCDRSRRGKRSSGndWKWGGCSHNLDFGEKFSRKFLDS----REKARDIHSRMNLHNNRAGRL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 252 VLKASLEMKCKCHGVSGSCSIKTCWKGLQELQDIALDLKNKYLSATKVV--HRPMGTRKYLVPKDIDIRPVKETELIYLQ 329
Cdd:cd19342   160 AVSENMERKCKCHGMSGSCELKTCWKAAPDFREVGDILKEKYDHATLVDqsNLNNGARRRRLTRRKRRRRPPKTDLVYYE 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1049400014 330 SSPDFCMKNEKVGSHGTQDRQCNKTSNGSDSCDLMCCGRGYNPYMDKVVERCHCKYHWCCYVTCKKCERTVERYVCK 406
Cdd:cd19342   240 RSPNFCEADPSLDSPGTRGRVCNKTSTGPDSCDSLCCGRGYNTVRQTRTERCNCRFHWCCYVVCEKCTETEWVTVCK 316
Wnt_Wnt7 cd19339
Wnt domain found in protein Wnt-7a, Wnt-7b and similar proteins; The family includes Wnt-7a ...
 97-406 3.24e-105

Wnt domain found in protein Wnt-7a, Wnt-7b and similar proteins; The family includes Wnt-7a and Wnt-7b. Wnt-7a acts as a canonical Wnt ligand that modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. It also plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development, and urogenital tract development. Wnt-7b functions in the canonical Wnt/beta-catenin signaling pathway in vascular smooth muscle cells. It is required for normal fusion of the chorion and the allantois during placenta development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381713  Cd Length: 313  Bit Score: 313.07  E-value: 3.24e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014  97 CKQLEGLVVSQVQLCRSNLELMQTIIQAAQEVIKTCRKTFSDMRWNCSSIELAPNYLLDLERGTRESAFVYALSAAAISH 176
Cdd:cd19339     2 CNKIPGLTPRQRAICQSRPDAIVAIGEGAQLGIEECQFQFRNHRWNCTLLGERTVFGQELPVGSREAAFTYAITSAGVAY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 177 TIARACTTGDLPGCSC--GPIPGETPGPGYRWGGCADNLNYGLIMGSKFSDApMKMKKSgsqANKLMHLHNSEVGRQVLK 254
Cdd:cd19339    82 AITQACSQGNLSDCGCdkSKKGYGKSDEGWKWGGCSADVKYGLRFSRKFVDA-REVKRN---ARSLMNLHNNEAGRKAVE 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 255 ASLEMKCKCHGVSGSCSIKTCWKGLQELQDIALDLKNKYLSATKVV----HRPMGTRKYLVPKDIDIRPVKETELIYLQS 330
Cdd:cd19339   158 ENLKLECKCHGVSGSCTTKTCWTTLPSFREIGDYLKKKYERARRVEpvrgRRRRRPTFLKLKISRKYKKPRPRDLVYLEK 237

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1049400014 331 SPDFCMKNEKVGSHGTQDRQCNKTSNGSDSCDLMCCGRGYNPYMDKVVERCHCKYHWCCYVTCKKCERTVERYVCK 406
Cdd:cd19339   238 SPNYCEKDPLTGSLGTVGRRCNRTSTGTDGCDLMCCGRGYNTHQYTKTWQCNCKFHWCCYVKCNTCSERTEEYTCK 313
Wnt_Wnt5a cd19347
Wnt domain found in protein Wnt-5a and similar proteins; Wnt-5a is a secreted growth factor ...
 97-406 9.27e-97

Wnt domain found in protein Wnt-5a and similar proteins; Wnt-5a is a secreted growth factor that belongs to the noncanonical members of the Wingless-related MMTV-integration family. It can activate or inhibit canonical Wnt signaling, depending on receptor context. Wnt-5a specifically regulates dendritic spine formation in rodent hippocampal neurons, resulting in postsynaptic development that promotes the clustering of the postsynaptic density protein 95 (PSD-95). Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381721  Cd Length: 312  Bit Score: 291.58  E-value: 9.27e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014  97 CKQLEGLVVSQVQLCRSNLELMQTIIQAAQEVIKTCRKTFSDMRWNCSSIELAPNYLLDLERGTRESAFVYALSAAAISH 176
Cdd:cd19347     1 CSQLAGLSQGQKKLCQLYQDHMQYIGEGAKTGIKECQYQFRHRRWNCSTVDNTSVFGRVMQIGSRETAFTYAISAAGVVN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 177 TIARACTTGDLPGCSCGPI--PGETPgPGYRWGGCADNLNYGLIMGSKFSDA----PMKMKKSGSQANKLMHLHNSEVGR 250
Cdd:cd19347    81 AVSRACREGELSTCGCSRAarPKDLP-RDWLWGGCGDNLEYGYRFAKEFVDArereKIYQKGSYESARTLMNLHNNEAGR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 251 QVLKASLEMKCKCHGVSGSCSIKTCWKGLQELQDIALDLKNKYLSATKVvhrPMGTRKYLVPKDIDIRPVKETELIYLQS 330
Cdd:cd19347   160 RTVYNLADVACKCHGVSGSCSLKTCWLQLADFRKVGDALKEKYDSAAAM---KLNSRGKLVQVNSRFNPPTTLDLVYIDP 236

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1049400014 331 SPDFCMKNEKVGSHGTQDRQCNKTSNGSDSCDLMCCGRGYNPYMDKVVERCHCKYHWCCYVTCKKCERTVERYVCK 406
Cdd:cd19347   237 SPDYCVRNESTGSLGTQGRLCNKTSEGMDGCELMCCGRGYDQFKTVQTERCHCKFHWCCYVKCKKCTEIVDQFVCK 312
Wnt_Wnt1 cd19333
Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called ...
 107-405 3.57e-92

Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called proto-oncogene Int-1, acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. It plays a role in osteoblast function, bone development and bone homeostasis. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381707  Cd Length: 311  Bit Score: 280.01  E-value: 3.57e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 107 QVQLCRSNLELMQTIIQAAQEVIKTCRKTFSDMRWNCSSIELA-PNYLLD--LERGTRESAFVYALSAAAISHTIARACT 183
Cdd:cd19333     5 QRRLVRQNPGTLHAIARGARMAIKECKWQFRNRRWNCPTTDSRgGPNVFGkiLNRGCRETAFIYAITSAAVTHSVARACS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 184 TGDLPGCSC-----GPipgetPGPGYRWGGCADNLNYGLIMGSKFSDAPMKmkksGSQANKLMHLHNSEVGRQVLKASLE 258
Cdd:cd19333    85 EGSIESCSCdyrrrGP-----GGPDWEWGGCSDNIDFGRKFSREFVDAGEK----GRDLRYLMNLHNNEAGRVHVSSEMR 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 259 MKCKCHGVSGSCSIKTCWKGLQELQDIALDLKNKYLSATKVVH--------RPMGTRKYLVPKDIDIRPVKETELIYLQS 330
Cdd:cd19333   156 QECKCHGMSGSCTVKTCWMRLPTFRTVGDRLKDRFDGASRVAYgnngnnrgSRRAKKFLLEPENPNHKPPTSKDLVYFEE 235

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1049400014 331 SPDFCMKNEKVGSHGTQDRQCNKTSNGSDSCDLMCCGRGYNPYMDKVVERCHCKYHWCCYVTCKKCERTVERYVC 405
Cdd:cd19333   236 SPNFCEKNPKLGTLGTRGRECNATSIGLDGCDLMCCGRGYRTETEEVKERCNCTFHWCCEVKCENCTRTRTVHTC 310
Wnt_Wnt5b cd19348
Wnt domain found in protein Wnt-5b and similar proteins; Wnt-5b is a secreted growth factor ...
 97-406 1.41e-91

Wnt domain found in protein Wnt-5b and similar proteins; Wnt-5b is a secreted growth factor that belongs to the noncanonical members of the Wingless-related MMTV-integration family. Its overexpression is associated with cancer aggressiveness. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381722  Cd Length: 312  Bit Score: 278.40  E-value: 1.41e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014  97 CKQLEGLVVSQVQLCRSNLELMQTIIQAAQEVIKTCRKTFSDMRWNCSSIELAPNYLLDLERGTRESAFVYALSAAAISH 176
Cdd:cd19348     1 CSQLTGLSPGQRKLCQLYQDHMVYIGEGAKTGIKECQYQFRQRRWNCSTVDNTSVFGRVMQIGSRETAFTYAVSAAGVVN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 177 TIARACTTGDLPGCSCGPI--PGETPgPGYRWGGCADNLNYGLIMGSKFSDAPMKMKK----SGSQANKLMHLHNSEVGR 250
Cdd:cd19348    81 AISRACREGELSTCGCSRAarPKDLP-RDWLWGGCGDNVEYGYRFAKEFVDAREREKNypkgSEEHARTLMNLQNNEAGR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 251 QVLKASLEMKCKCHGVSGSCSIKTCWKGLQELQDIALDLKNKYLSATKVvhrPMGTRKYLVPKDIDIRPVKETELIYLQS 330
Cdd:cd19348   160 RAVYNLADVACKCHGVSGSCSLKTCWLQLADFRKVGDLLKEKYDSAAAM---RINRKGKLELVNSRFNPPTAEDLVYIDP 236

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1049400014 331 SPDFCMKNEKVGSHGTQDRQCNKTSNGSDSCDLMCCGRGYNPYMDKVVERCHCKYHWCCYVTCKKCERTVERYVCK 406
Cdd:cd19348   237 SPDYCLRNETTGSLGTQGRLCNKTSEGMDGCELMCCGRGYDQFKTVQVERCHCKFHWCCYVKCKKCTEIVDQFVCK 312
Wnt_Wnt9 cd19341
Wnt domain found in protein Wnt-9a, Wnt-9b and similar proteins; The family includes Wnt-9a ...
 107-406 2.84e-91

Wnt domain found in protein Wnt-9a, Wnt-9b and similar proteins; The family includes Wnt-9a and Wnt-9b, both of which function in the canonical Wnt/beta-catenin signaling pathway. Wnt-9a, also called protein Wnt-14, is required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Wnt-9a plays a redundant role in maintaining joint integrity. It is a conserved regulator of hematopoietic stem and progenitor cell development. Wnt-9b, also called protein Wnt-14b, or protein Wnt-15, plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381715  Cd Length: 299  Bit Score: 277.25  E-value: 2.84e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 107 QVQLCRSNLELMQTIIQAAQEVIKTCRKTFSDMRWNCSSIELAPNYLldlERGTRESAFVYALSAAAISHTIARACTTGD 186
Cdd:cd19341     5 QRRMCRRDPGLAETLLEAIRLSVLECQEQFRYERWNCSLGKYRINLL---KKGYKETAFLYAISSAGLTHSVARACSSGR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 187 LPGCSCGPIPG-ETPGPGYRWGGCADNLNYGlimgSKFSDAPMKMKKSGSQANK-LMHLHNSEVGRQVLKASLEMKCKCH 264
Cdd:cd19341    82 LDRCTCDESFSlEENRQTWLWGGCGDNIKYG----KKFTRRFLQLKKKSGKDLRaEIDRHNSEVGIRVVREGVKKTCKCH 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 265 GVSGSCSIKTCWKGLQELQDIALDLKNKYLSATKVVH------RPMGTRKYLVPKDIDIRPVKETELIYLQSSPDFCMKN 338
Cdd:cd19341   158 GVSGSCTVKTCWKQLAPFNEIGKILKRKYEKAVKVVSennaatGGSQLRKGKSGSVKKKSRPRRKDLVYLEKSPSFCRST 237

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1049400014 339 ekVGSHGTQDRQCNKTSNgsdsCDLMCCGRGYNPYMDKVVERCHCKYHWCCYVTCKKCERTVERYVCK 406
Cdd:cd19341   238 --RYSPGTKGRRCLKGDN----CDTLCCGRGYNTQSEVVVKPCKCRVVWCCQVECKTCTEREEIYTCK 299
Wnt_Wnt2 cd19345
Wnt domain found in protein Wnt-2 and similar proteins; Wnt-2, also called Int-1-like protein ...
 97-406 2.10e-88

Wnt domain found in protein Wnt-2 and similar proteins; Wnt-2, also called Int-1-like protein 1 (INT1L1), or Int-1-related protein (IRP), functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It plays an important role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381719  Cd Length: 314  Bit Score: 270.27  E-value: 2.10e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014  97 CKQLEGLVVSQVQLCRSNLELMQTIIQAAQEVIKTCRKTFSDMRWNCSSIELAPNYLLD-LERGTRESAFVYALSAAAIS 175
Cdd:cd19345     6 CDNIPGLVSRQRQLCHRHPEVMQAIGSGVKEWIAECQHQFRNHRWNCNTLDRDHSLFGRlLLRSSRESAFVYAISSAGVV 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 176 HTIARACTTGDLPGCSCGPIPGETPGPG---YRWGGCADNLNYGLIMGSKFSDAPmkmKKSGSQANKLMHLHNSEVGRQV 252
Cdd:cd19345    86 FAITRACSQGELKSCSCDPKKKGSSKDSkgsFDWGGCSDNIDYGIRFARAFVDAK---ERKGKDARALMNLHNNRAGRKA 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 253 LKASLEMKCKCHGVSGSCSIKTCWKGLQELQDIALDLKNKYLSATKVVHRPMGTRKYLVPKDIDiRPVKeTELIYLQSSP 332
Cdd:cd19345   163 VKRFMTLECKCHGVSGSCTVRTCWLAMADFRKTGDYLRKKYNGAIQVVMNQDGTGFTVANKHFK-KPTK-NDLVYFENSP 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1049400014 333 DFCMKNEKVGSHGTQDRQCNKTSNGSDSCDLMCCGRGYNPYMDKVVERCHCKYHWCCYVTCKKCERTVERYVCK 406
Cdd:cd19345   241 DYCVRDRDAGSLGTAGRVCNRTSRGMDGCEVMCCGRGYDTSRVGRMTKCECKFHWCCAVRCKDCHQQVDVHTCK 314
Wnt_Wnt2b cd19346
Wnt domain found in protein Wnt-2b and similar proteins; Wnt-2b, also called protein Wnt-13, ...
 97-406 1.18e-87

Wnt domain found in protein Wnt-2b and similar proteins; Wnt-2b, also called protein Wnt-13, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a redundant role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381720  Cd Length: 314  Bit Score: 268.33  E-value: 1.18e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014  97 CKQLEGLVVSQVQLCRSNLELMQTIIQAAQEVIKTCRKTFSDMRWNCSSIELAPNYLLD-LERGTRESAFVYALSAAAIS 175
Cdd:cd19346     6 CDNIPGLVNKQRQLCQRHPDIMQSIGEGAKEWIRECQHQFRHHRWNCSTLDRDHTVFGRvMLRSSREAAFVYAISSAGVV 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 176 HTIARACTTGDLPGCSCGPIPG----ETPGPgYRWGGCADNLNYGLIMGSKFSDAPMKMKKSgsqANKLMHLHNSEVGRQ 251
Cdd:cd19346    86 YAITRACSQGELKSCSCDPHKRgrshDERGE-FDWGGCSDNINYGIKFAKAFVDAKEKKEKD---ARALMNLHNNRCGRM 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 252 VLKASLEMKCKCHGVSGSCSIKTCWKGLQELQDIALDLKNKYLSATKVVHRPMGTRkyLVPKDIDIRPVKETELIYLQSS 331
Cdd:cd19346   162 AVKRFMKLECKCHGVSGSCTLRTCWLAMSDFRKTGDYLRKRYNGAVQVTMNQDGTG--FTVANKNFRKATKTDLVYFENS 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1049400014 332 PDFCMKNEKVGSHGTQDRQCNKTSNGSDSCDLMCCGRGYNPYMDKVVERCHCKYHWCCYVTCKKCERTVERYVCK 406
Cdd:cd19346   240 PDYCVMDKSAGSLGTAGRVCNKSSRGTDGCEVMCCGRGYDTTRVTRVTKCECKFHWCCAVRCKECEETVDVHTCK 314
Wnt_Wnt7a cd19349
Wnt domain found in protein Wnt-7a and similar proteins; Wnt-7a acts as a canonical Wnt ligand ...
 97-406 6.11e-85

Wnt domain found in protein Wnt-7a and similar proteins; Wnt-7a acts as a canonical Wnt ligand that modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. It also plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381723  Cd Length: 318  Bit Score: 261.52  E-value: 6.11e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014  97 CKQLEGLVVSQVQLCRSNLELMQTIIQAAQEVIKTCRKTFSDMRWNCSSIELAPNYLLDLERGTRESAFVYALSAAAISH 176
Cdd:cd19349     7 CNKIPGLAPRQRAICQSRPDAIIVIGEGAQMGINECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAIIAAGVAH 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 177 TIARACTTGDLPGCSCGPipgETPG-----PGYRWGGCADNLNYGLIMGSKFSDApmkmKKSGSQANKLMHLHNSEVGRQ 251
Cdd:cd19349    87 AITAACTQGNLSDCGCDK---EKQGqynqeEGWKWGGCSADIRYGIGFSKVFVDA----REIKQNARTLMNLHNNEAGRK 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 252 VLKASLEMKCKCHGVSGSCSIKTCWKGLQELQDIALDLKNKYLSATKVvhRPMGTRKYLVP------KDIDIRPVKETEL 325
Cdd:cd19349   160 ILEENMKLECKCHGVSGSCTTKTCWTTLPKFRELGYILKDKYNEAVHV--EPVRASRNKRPtflkikKPLSYRKPMDTDL 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 326 IYLQSSPDFCMKNEKVGSHGTQDRQCNKTSNGSDSCDLMCCGRGYNPYMDKVVERCHCKYHWCCYVTCKKCERTVERYVC 405
Cdd:cd19349   238 VYIEKSPNYCEEDPVTGSVGTQGRMCNKTAQQNNGCDLMCCGRGYNTHQYSRVWQCNCKFHWCCYVKCNTCSERTEVYTC 317


                  .
gi 1049400014 406 K 406
Cdd:cd19349   318 K 318
Wnt_Wnt8 cd19340
Wnt domain found in protein Wnt-8a, Wnt-8b and similar proteins; The family includes Wnt-8a ...
 109-405 1.93e-81

Wnt domain found in protein Wnt-8a, Wnt-8b and similar proteins; The family includes Wnt-8a and Wnt-8b. Wnt-8a, also called protein Wnt-8d, plays a role in embryonic patterning. Wnt-8b may play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. It acts as a suppressor of early eye and retinal progenitor formation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381714  Cd Length: 301  Bit Score: 252.21  E-value: 1.93e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 109 QLCRSNLELMQTIIQAAQEVIKTCRKTFSDMRWNC--SSIELAPNYLldleRGTRESAFVYALSAAAISHTIARACTTGD 186
Cdd:cd19340     1 SGPKAYLSLSDSVAAGAQLAMEECQYQFKWDRWNCpeSAFFSQKNNP----SATRETAFVHAISSAGVMYTLTRNCSLGH 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 187 LPGCSCGP-IPGETPGPGYRWGGCADNLNYGLIMGSKFSDAPMKMKKSGSqankLMHLHNSEVGRQVLKASLEMKCKCHG 265
Cdd:cd19340    77 FEGCGCDDsKKGSKGGEGWTWGGCSDNVKFGERVSKKFLDSLETGQDAQA----LMNLHNNRAGRKAVRKTMKKTCKCHG 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 266 VSGSCSIKTCWKGLQELQDIALDLKNKYLSATKVVHRPMGTRKYLVPKDIDIRPVKETELIYLQSSPDFCMKNEKVGSHG 345
Cdd:cd19340   153 VSGSCSTQTCWMQLAPFREIGTDLKRKYDRAVRVDYENGGLRETNGSRAIKLLNIKKNDLVYLEKSPNYCRANVTLGWPG 232

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1049400014 346 TQDRQCNKTSNGSD------SCDLMCCGRGYNPYMDKVVE--RCHCKYHWCCYVTCKKCERTVERYVC 405
Cdd:cd19340   233 TLGRQCSRDKKESVsrwerkSCRRLCRACGLKVRKKVVEVtsSCNCKFHWCCEVKCETCVELVIEYTC 300
wnt_Wnt7b cd19350
Wnt domain found in protein Wnt-7b and similar proteins; Wnt-7b functions in the canonical Wnt ...
 97-406 1.10e-80

Wnt domain found in protein Wnt-7b and similar proteins; Wnt-7b functions in the canonical Wnt/beta-catenin signaling pathway in vascular smooth muscle cells. It is required for normal fusion of the chorion and the allantois during placenta development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381724  Cd Length: 318  Bit Score: 250.70  E-value: 1.10e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014  97 CKQLEGLVVSQVQLCRSNLELMQTIIQAAQEVIKTCRKTFSDMRWNCSSIELAPNYLLDLERGTRESAFVYALSAAAISH 176
Cdd:cd19350     7 CNKIPGLAPRQRAICQSRPDAIIVIGEGAQMGINECQYQFRYGRWNCSALGERTVFGQELRVGSREAAFTYAITAAGVAH 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 177 TIARACTTGDLPGCSCGPipgETPG-----PGYRWGGCADNLNYGLIMGSKFSDApMKMKKSgsqANKLMHLHNSEVGRQ 251
Cdd:cd19350    87 AVTAACSQGNLSNCGCDR---EKQGyynqeEGWKWGGCSADIKYGIDFSRKFVDA-REIKKN---ARRLMNLHNNEAGRK 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 252 VLKASLEMKCKCHGVSGSCSIKTCWKGLQELQDIALDLKNKYLSATKV-VHRPMGTRKYLVPKDIDIRPVK---ETELIY 327
Cdd:cd19350   160 VLEERMKLECKCHGVSGSCTTKTCWTTLPKFREIGYVLKEKYNAAVQVeVVRASRLRQPTFLKIKKRRSYQkpmETDLVY 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1049400014 328 LQSSPDFCMKNEKVGSHGTQDRQCNKTSNGSDSCDLMCCGRGYNPYMDKVVERCHCKYHWCCYVTCKKCERTVERYVCK 406
Cdd:cd19350   240 IERSPNYCEEDAATGSVGTQGRLCNRTSPHTDGCDLMCCGRGYNTHQYTKVWQCNCKFHWCCFVKCNTCSERTEVFTCK 318
Wnt_Wnt10a cd19355
Wnt domain found in protein Wnt-10a and similar proteins; Wnt-10a plays a role in normal ...
 97-406 1.07e-78

Wnt domain found in protein Wnt-10a and similar proteins; Wnt-10a plays a role in normal ectoderm development. It is required for normal postnatal development and maintenance of tongue papillae and sweat ducts, as well as normal hair follicle function. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381729  Cd Length: 302  Bit Score: 245.28  E-value: 1.07e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014  97 CKQLEGLVVSQVQLCRSNLELMQTIIQAAQEVIKTCRKTFSDMRWNCSSIELA---PNYLLDLERGTRESAFVYALSAAA 173
Cdd:cd19355     4 CLTLPGLTRRQLEVCMRHPDVTASAIQGIQIAIHECQHQFRDHRWNCSSLETRnkiPYESVVFSRGFRESAFAYAIAAAG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 174 ISHTIARACTTGDLPGCSCGpipgetpgpgYRWGGCADNLNYGlimgSKFSDAPMKMKKSGSQANKLMHLHNSEVGRQVL 253
Cdd:cd19355    84 VVHAVSNACAMGKLKACGCD----------WEWGGCSPDVEYG----ERFSKDFLDSRETYRDIHARMRLHNNRVGRQVV 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 254 KASLEMKCKCHGVSGSCSIKTCWKGLQELQDIALDLKNKYLSATKVVHRPMGTRKYLVPKDIDIRPVKETELIYLQSSPD 333
Cdd:cd19355   150 MDNMRRKCKCHGTSGSCQLKTCWQVTPEFRTVGSLLKDRFYVATLIKPHNRNTGQLEPGHAPHRRRASINDLVYFEKSPD 229

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1049400014 334 FCMKNEKVGSHGTQDRQCNKTSNGSDSCDLMCCGRGYNPYMDKVVERCHCKYHWCCYVTCKKCERTVERYVCK 406
Cdd:cd19355   230 FCEREPRLDSAGTQGRICNKTSPGMDNCESLCCGRGHNILRQTRSERCNCKFHWCCYVVCEECRITEWVSVCK 302
Wnt_Wnt10b cd19356
Wnt domain found in protein Wnt-10b and similar proteins; Wnt-10b, also called protein Wnt-12, ...
 97-406 9.32e-74

Wnt domain found in protein Wnt-10b and similar proteins; Wnt-10b, also called protein Wnt-12, specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. It is involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Wnt-10b is unique and plays an important role in differentiation of epithelial cells in the hair follicle. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381730  Cd Length: 299  Bit Score: 232.47  E-value: 9.32e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014  97 CKQLEGLVVSQVQLCRSNLELMQTIIQAAQEVIKTCRKTFSDMRWNCSSIELAPNYLLD---LERGTRESAFVYALSAAA 173
Cdd:cd19356     4 CLTLPGLSKRQMGLCVRSPDVTASALQGIQIAIHECQHQLRDQRWNCSSLEGGGKLPHDsaiLKRGFRESAFSFSLLAAG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 174 ISHTIARACTTGDLPGCSCGpipgetpgpgYRWGGCADNLNYGlimgSKFSDAPMKMKKSGSQANKLMHLHNSEVGRQVL 253
Cdd:cd19356    84 VMHSVATACSLGKLRGCGCE----------WEWGGCSHDIEFG----EKFSRDFLDSRESPRDIQARMRIHNNRVGRQVV 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 254 KASLEMKCKCHGVSGSCSIKTCWKGLQELQDIALDLKNKYLSATKVVHRPMGTRKYLvPKdidIRPVK-ETELIYLQSSP 332
Cdd:cd19356   150 TENMKRKCKCHGTSGSCQFKTCWHVTPEFRLVGALLREKFQRAIFINSHNKNSGVFL-PR---LRPRRlARELVYFEKSP 225

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1049400014 333 DFCMKNEKVGSHGTQDRQCNKTSNGSDSCDLMCCGRGYNPYMDKVVERCHCKYHWCCYVTCKKCERTVERYVCK 406
Cdd:cd19356   226 DFCERDPAVDSPGTQGRICNKTSPGMDGCGSLCCGRGHNILKQTRSERCHCRFHWCCYVLCEECRVTEWVNVCK 299
Wnt_Wnt9b cd19354
Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b ...
 107-406 2.32e-72

Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b or Wnt-15, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381728  Cd Length: 297  Bit Score: 228.63  E-value: 2.32e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 107 QVQLCRSNLELMQTIIQAAQEVIKTCRKTFSDMRWNCSsielapnylLD-----LERGTRESAFVYALSAAAISHTIARA 181
Cdd:cd19354     5 QKRLCRREPGLAETLRDAVRLGLLECQFQFRSERWNCS---------LEgrgslLKRGFKETAFLYAVSSAALTHSLAKA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 182 CTTGDLPGCSCGPIPGETPGPGYRWGGCADNLNYGlimgSKFSDAPMKMKKSGSQANKLMHLHNSEVGRQVLKASLEMKC 261
Cdd:cd19354    76 CSSGRMERCTCDDSPGLENREAWQWGVCGDNLKYS----TKFLKNFLGQKKGSKDLRARVDAHNTNVGIKAVKSGLKTTC 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 262 KCHGVSGSCSIKTCWKGLQELQDIALDLKNKYLSATKV---VHRPMGTRKYLVPKD----IDIRPVKETELIYLQSSPDF 334
Cdd:cd19354   152 KCHGVSGSCAVRTCWKQLSPFHETGRLLKLKYENAVKVhsvTNDATGETELWSPERhghtLKGHSPRSTDLVYLEDSPSF 231

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1049400014 335 CMKNEKvgSHGTQDRQCNKTSNgsdsCDLMCCGRGYNPYMDKVVERCHCKYHWCCYVTCKKCERTVERYVCK 406
Cdd:cd19354   232 CRPSKY--SPGTAGRTCSRETN----CDSLCCGRGYNTQSRLVTFSCHCQVQWCCYVECQQCVQEEEVYTCK 297
Wnt_Wnt8a cd19351
Wnt domain found in protein Wnt-8a and similar proteins; Wnt-8a, also called protein Wnt-8d, ...
 125-405 2.95e-68

Wnt domain found in protein Wnt-8a and similar proteins; Wnt-8a, also called protein Wnt-8d, plays a role in embryonic patterning. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381725  Cd Length: 307  Bit Score: 218.23  E-value: 2.95e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 125 AQEVIKTCRKTFSDMRWNCSSIELAPNYLLDLERGTRESAFVYALSAAAISHTIARACTTGDLPGCSC-GPIPGETPGPG 203
Cdd:cd19351    17 AQSGIEECKHQFAWERWNCPESALQLSTHNGLRSATRETSFVHAISSAGVMYTLTRNCSLGDFENCGCdDSRNGRTGGRG 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 204 YRWGGCADNLNYGLIMGSKFSDApmkmKKSGSQANKLMHLHNSEVGRQVLKASLEMKCKCHGVSGSCSIKTCWKGLQELQ 283
Cdd:cd19351    97 WIWGGCSDNVEFGERISKQFVDA----LETGQDARALMNLHNNEAGRLAVKATMKRTCKCHGVSGSCSIQTCWLQLADFR 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 284 DIALDLKNKYLSATKVvhrPMGTRKYLVPKDIDIR--------PVKETELIYLQSSPDFCMKNEKVGSHGTQDRQCNKTS 355
Cdd:cd19351   173 EIGNYLKVKHDQALKL---EMDKRRMRAGNSADNRgaiaeafgSVAETELIYLEDSPDYCTKNASLGLQGTEGRECLQSG 249

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1049400014 356 NGSD-----SCDLMC--CGRGYNPYMDKVVERCHCKYHWCCYVTCKKCERTVERYVC 405
Cdd:cd19351   250 KNLSqwerrSCRRLCteCGLRVEERRTEVVSSCNCKFHWCCTVKCEQCRQVVTKHYC 306
Wnt_Wnt9a cd19353
Wnt domain found in protein Wnt-9a and similar proteins; Wnt-9a, also called protein Wnt-14, ...
 107-406 5.10e-67

Wnt domain found in protein Wnt-9a and similar proteins; Wnt-9a, also called protein Wnt-14, functions in the canonical Wnt/beta-catenin signaling pathway. It is required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Wnt-9a plays a redundant role in maintaining joint integrity. It is a conserved regulator of hematopoietic stem and progenitor cell development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381727  Cd Length: 298  Bit Score: 214.90  E-value: 5.10e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 107 QVQLCRSNLELMQTIIQAAQEVIKTCRKTFSDMRWNCSsieLAPNYLLDL-ERGTRESAFVYALSAAAISHTIARACTTG 185
Cdd:cd19353     5 QRRMCRRDPGVAETLMEAISMSALECQYQFRFERWNCT---LEGRYRASLlKRGFKETAFLYAISSAGLTHAMAKACSAG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 186 DLPGCSCGPIPGETPGPGYRWGGCADNLNYGlimgSKFSDAPMKmKKSGSQANKLMHLHNSEVGRQVLKASLEMKCKCHG 265
Cdd:cd19353    82 RMERCTCDEAPDLENREAWQWGGCGDNLKYS----NKFVKEFLG-RKSSKDLRARVDFHNNLVGIKVIKAGVETTCKCHG 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 266 VSGSCSIKTCWKGLQELQDIALDLKNKYLSATKVvhrpmGTRKYLVPKDIDIRPVKE------------TELIYLQSSPD 333
Cdd:cd19353   157 VSGSCTVRTCWRQLSPFHEIGKQLKQKYETSLKV-----GSTTNEATGEGDISPPKKsgaghsdqiprtTDLVYIDDSPS 231

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1049400014 334 FCMKNEKvgSHGTQDRQCNKTSNgsdsCDLMCCGRGYNPYMDKVVERCHCKYHWCCYVTCKKCERTVERYVCK 406
Cdd:cd19353   232 FCLMSRF--SPGTSGRRCYKDKN----CESICCGRGHNTQSRVVTRPCQCQVRWCCYVECKQCTQREEVYTCK 298
Wnt_Wnt8b cd19352
Wnt domain found in protein Wnt-8b and similar proteins; Wnt-8b may play an important role in ...
 120-405 2.60e-64

Wnt domain found in protein Wnt-8b and similar proteins; Wnt-8b may play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. It acts as a suppressor of early eye and retinal progenitor formation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381726  Cd Length: 305  Bit Score: 208.34  E-value: 2.60e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 120 TIIQAAQEVIKTCRKTFSDMRWNCSSIELAPNYLLDLERGTRESAFVYALSAAAISHTIARACTTGDLPGCSCGPI-PGE 198
Cdd:cd19352    13 SVAAGAQSGIEECKYQFAWDRWNCPERALQLSSHSGLRSANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDDSrNGQ 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 199 TPGPGYRWGGCADNLNYGLIMGSKFSDApmkmKKSGSQANKLMHLHNSEVGRQVLKASLEMKCKCHGVSGSCSIKTCWKG 278
Cdd:cd19352    93 LGGQGWLWGGCSDNVGFGEAISKQFVDA----LETGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCWLQ 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1049400014 279 LQELQDIALDLKNKYLSATKV-----VHRPMGTRKYLVPKdidIRPVKETELIYLQSSPDFCMKNEKVGSHGTQDRQCNK 353
Cdd:cd19352   169 LPEFREVGNYLKEKYHRALKVdllqgAGNSAASRGAIAET---FRSISKKELVHLEDSPDYCLENKTLGLLGTEGRECLK 245

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1049400014 354 TSNG-----SDSCDLMC--CGRGYNPYMDKVVERCHCKYHWCCYVTCKKCERTVERYVC 405
Cdd:cd19352   246 RGKAlskweKRSCRRLCgdCGLAVEERRAEMVSSCNCKFHWCCAVKCEQCRKTVTKYFC 304
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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