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Conserved domains on  [gi|672035060|ref|XP_008757160|]
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protein capicua homolog isoform X9 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HMG-box_CIC-like cd21990
high mobility group (HMG)-box found in protein capicua (CIC) and similar proteins; CIC is a ...
 199-276 1.42e-59

high mobility group (HMG)-box found in protein capicua (CIC) and similar proteins; CIC is a transcriptional repressor which plays a role in the development of the central nervous system (CNS). In concert with ATXN1 and ATXN1L, CIC is involved in brain development.


:

Pssm-ID: 438806 [Multi-domain]  Cd Length: 78  Bit Score: 198.45  E-value: 1.42e-59
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672035060  199 HIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKWCNKDRKK 276
Cdd:cd21990     1 HIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPEEKQKYHDLAFQVKEAHFKAHPDWKWCSKDRKK 78
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 732-1274 5.60e-13

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 74.59  E-value: 5.60e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  732 AAATSPAPHLVAGPLLGTVGKAPATVTNLLVGTPGYGAPASPAVQFIAQGAPGsatpagSGASAGSGPNGPVPLGILQPG 811
Cdd:PHA03247 2445 AGLAADGDPFFARTILGAPFSLSLLLGELFPGAPVYRRPAEARFPFAAGAAPD------PGGGGPPDPDAPPAPSRLAPA 2518

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  812 ALGKAGGITQVQYILPTLPQQLQVAPAPAPAPGTKAAAPSGPAPTTSIRFTLP-PGTSTNGKVLAATAPTAGIPILQSVP 890
Cdd:PHA03247 2519 ILPDEPVGEPVHPRMLTWIRGLEELASDDAGDPPPPLPPAAPPAAPDRSVPPPrPAPRPSEPAVTSRARRPDAPPQSARP 2598

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  891 SAP-PPKAQSVSPVQATPSGGSAQLLPGKVLVPLAAPSMSVRGGGAGQPLPLVSSPFSVPVQNGAQQPSKIIQLTPVPVS 969
Cdd:PHA03247 2599 RAPvDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASS 2678

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  970 TPSGLVPPLSPATMPGPTSQPQKVLLPSSTRITYVQSAGGHTLPLGTSSAcsqtgtvtsygPASSVALGFTSLGPSGPAf 1049
Cdd:PHA03247 2679 PPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAA-----------RQASPALPAAPAPPAVPA- 2746

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1050 vQPLLSAGQAPLLAPGQVGVSPVPSPQLPPACTAPGGPVITAFYPGSPAPTSAPLGPPSQAPPSLVYTVATSTTPPAAAI 1129
Cdd:PHA03247 2747 -GPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPA 2825

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1130 LPKGPPASATATPAPTSPFPSATAGSMTYSLV--APKAQRPSPKAPQKVKAAIASIPVGSFESgttgrtgPTPRQSLDSg 1207
Cdd:PHA03247 2826 GPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVApgGDVRRRPPSRSPAAKPAAPARPPVRRLAR-------PAVSRSTES- 2897

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 672035060 1208 varePAAPESELEGQPTPPAPPPPTETWPPTARSSPPPPLPAEERPGTKGPETASKFPSSSSDWRVP 1274
Cdd:PHA03247 2898 ----FALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVP 2960
NHP6B super family cl26372
Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics];
156-315 1.98e-07

Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics];


The actual alignment was detected with superfamily member COG5648:

Pssm-ID: 227935 [Multi-domain]  Cd Length: 211  Bit Score: 53.33  E-value: 1.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  156 MSPEIQL--PLPPG-----KRRTQSLSALPKERDSSSEKDGRSPnkrekdhiRRPMNAFMIFSKRHRALVHQRHPNQDNR 228
Cdd:COG5648    28 MSGIRQLhtTLVELekplqQLLTKPRKKTKSKRLVRKKKDPNGP--------KRPLSAYFLYSAENRDEIRKENPKLTFG 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  229 TVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKA-HPDwkwcnkDRKKSSSEAKPASLGLAGGHKETRERSMSETG--- 304
Cdd:COG5648   100 EVGKLLSEKWKELTDEEKEPYYKEANSDRERYQREkEEY------NKKLPNKAPIGPFIENEPKIRPKVEGPSPDKAlve 173

                         170
                  ....*....|..
gi 672035060  305 -TAAAPGVSSEL 315
Cdd:COG5648   174 eTKIISKAWSEL 185
PRK07764 super family cl35613
DNA polymerase III subunits gamma and tau; Validated
 45-151 5.55e-03

DNA polymerase III subunits gamma and tau; Validated


The actual alignment was detected with superfamily member PRK07764:

Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.51  E-value: 5.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060   45 APSQPDPSVQPSEAQQPASHPVASNQ-SKEPAESAAVAHEQPPGGTGGADPGRPPGATCPESPGPGPPLTLGGVDPGKSL 123
Cdd:PRK07764  683 PAPAPAAPAAPAGAAPAQPAPAPAATpPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPP 762

                          90       100
                  ....*....|....*....|....*...
gi 672035060  124 PPTTEEEAPGPPGEPRLDSETESDHDDA 151
Cdd:PRK07764  763 APAPAAAPAAAPPPSPPSEEEEMAEDDA 790
PRK07003 super family cl35530
DNA polymerase III subunit gamma/tau;
646-788 5.93e-03

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK07003:

Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 41.37  E-value: 5.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  646 SAPAPSLAYGAPAAPLCRPAATMVTNVVRPVSSTPVPIASKPFPTSGRAEASSNDTVGARTEMGTGSRVPGGSPLGVSLV 725
Cdd:PRK07003  383 PGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGDAPVPAKANARASADSR 462

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672035060  726 YSDKKSAAATSPAPHLVAGPllgtvgKAPATVTNllvgtpgygAPASPAVQFIAQGAPGSATP 788
Cdd:PRK07003  463 CDERDAQPPADSGSASAPAS------DAPPDAAF---------EPAPRAAAPSAATPAAVPDA 510
 
Name Accession Description Interval E-value
HMG-box_CIC-like cd21990
high mobility group (HMG)-box found in protein capicua (CIC) and similar proteins; CIC is a ...
 199-276 1.42e-59

high mobility group (HMG)-box found in protein capicua (CIC) and similar proteins; CIC is a transcriptional repressor which plays a role in the development of the central nervous system (CNS). In concert with ATXN1 and ATXN1L, CIC is involved in brain development.


Pssm-ID: 438806 [Multi-domain]  Cd Length: 78  Bit Score: 198.45  E-value: 1.42e-59
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672035060  199 HIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKWCNKDRKK 276
Cdd:cd21990     1 HIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPEEKQKYHDLAFQVKEAHFKAHPDWKWCSKDRKK 78
HMG smart00398
high mobility group;
199-268 6.12e-19

high mobility group;


Pssm-ID: 197700 [Multi-domain]  Cd Length: 70  Bit Score: 82.36  E-value: 6.12e-19
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060    199 HIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWK 268
Cdd:smart00398    1 KPKRPMSAFMLFSQENRAKIKAENPDLSNAEISKKLGERWKLLSEEEKAPYEEKAKKDKERYEEEMPEYK 70
HMG_box pfam00505
HMG (high mobility group) box;
200-267 1.64e-17

HMG (high mobility group) box;


Pssm-ID: 459837 [Multi-domain]  Cd Length: 68  Bit Score: 78.04  E-value: 1.64e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672035060   200 IRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDW 267
Cdd:pfam00505    1 PKRPMSAFFLFSKEQRAKLKAENPGLKNAEISKILGEKWKALSEEEKKPYEEKAEKEKARYEKEHPEY 68
PHA03247 PHA03247
large tegument protein UL36; Provisional
 732-1274 5.60e-13

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 74.59  E-value: 5.60e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  732 AAATSPAPHLVAGPLLGTVGKAPATVTNLLVGTPGYGAPASPAVQFIAQGAPGsatpagSGASAGSGPNGPVPLGILQPG 811
Cdd:PHA03247 2445 AGLAADGDPFFARTILGAPFSLSLLLGELFPGAPVYRRPAEARFPFAAGAAPD------PGGGGPPDPDAPPAPSRLAPA 2518

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  812 ALGKAGGITQVQYILPTLPQQLQVAPAPAPAPGTKAAAPSGPAPTTSIRFTLP-PGTSTNGKVLAATAPTAGIPILQSVP 890
Cdd:PHA03247 2519 ILPDEPVGEPVHPRMLTWIRGLEELASDDAGDPPPPLPPAAPPAAPDRSVPPPrPAPRPSEPAVTSRARRPDAPPQSARP 2598

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  891 SAP-PPKAQSVSPVQATPSGGSAQLLPGKVLVPLAAPSMSVRGGGAGQPLPLVSSPFSVPVQNGAQQPSKIIQLTPVPVS 969
Cdd:PHA03247 2599 RAPvDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASS 2678

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  970 TPSGLVPPLSPATMPGPTSQPQKVLLPSSTRITYVQSAGGHTLPLGTSSAcsqtgtvtsygPASSVALGFTSLGPSGPAf 1049
Cdd:PHA03247 2679 PPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAA-----------RQASPALPAAPAPPAVPA- 2746

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1050 vQPLLSAGQAPLLAPGQVGVSPVPSPQLPPACTAPGGPVITAFYPGSPAPTSAPLGPPSQAPPSLVYTVATSTTPPAAAI 1129
Cdd:PHA03247 2747 -GPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPA 2825

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1130 LPKGPPASATATPAPTSPFPSATAGSMTYSLV--APKAQRPSPKAPQKVKAAIASIPVGSFESgttgrtgPTPRQSLDSg 1207
Cdd:PHA03247 2826 GPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVApgGDVRRRPPSRSPAAKPAAPARPPVRRLAR-------PAVSRSTES- 2897

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 672035060 1208 varePAAPESELEGQPTPPAPPPPTETWPPTARSSPPPPLPAEERPGTKGPETASKFPSSSSDWRVP 1274
Cdd:PHA03247 2898 ----FALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVP 2960
NHP6B COG5648
Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics];
156-315 1.98e-07

Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics];


Pssm-ID: 227935 [Multi-domain]  Cd Length: 211  Bit Score: 53.33  E-value: 1.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  156 MSPEIQL--PLPPG-----KRRTQSLSALPKERDSSSEKDGRSPnkrekdhiRRPMNAFMIFSKRHRALVHQRHPNQDNR 228
Cdd:COG5648    28 MSGIRQLhtTLVELekplqQLLTKPRKKTKSKRLVRKKKDPNGP--------KRPLSAYFLYSAENRDEIRKENPKLTFG 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  229 TVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKA-HPDwkwcnkDRKKSSSEAKPASLGLAGGHKETRERSMSETG--- 304
Cdd:COG5648   100 EVGKLLSEKWKELTDEEKEPYYKEANSDRERYQREkEEY------NKKLPNKAPIGPFIENEPKIRPKVEGPSPDKAlve 173

                         170
                  ....*....|..
gi 672035060  305 -TAAAPGVSSEL 315
Cdd:COG5648   174 eTKIISKAWSEL 185
PTZ00199 PTZ00199
high mobility group protein; Provisional
 183-257 5.15e-07

high mobility group protein; Provisional


Pssm-ID: 185511 [Multi-domain]  Cd Length: 94  Bit Score: 49.08  E-value: 5.15e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 672035060  183 SSSEKDGRSPNKREKDHI--RRPMNAFMIFSKRHRALVHQRHPN--QDNRTVSKILGEWWYALGPKEKQKYHDLAFQVK 257
Cdd:PTZ00199    4 KQGKVLVRKNKRKKKDPNapKRALSAYMFFAKEKRAEIIAENPElaKDVAAVGKMVGEAWNKLSEEEKAPYEKKAQEDK 82
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
967-1176 3.70e-05

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 48.21  E-value: 3.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  967 PVSTPSGLVPPLSPATMPGPTSQPQKVL-LPSSTRITYVQSAGGHTLPLGTSSACSQTGTVTSYGPASSVALGFTSLGPS 1045
Cdd:COG3469    11 TAGGASATAVTLLGAAATAASVTLTAATaTTVVSTTGSVVVAASGSAGSGTGTTAASSTAATSSTTSTTATATAAAAAAT 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1046 GPAFVQPLLSAGQAPLLAPGQVGVSPVPSPQLPPACTAPGGPVITAFYPGSPAPTSAPLGPPSQAPPSLVYTVATSTTPP 1125
Cdd:COG3469    91 STSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETATGGTTTTSTTT 170

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 672035060 1126 AAAILPKGPPASATATPAPTSPFPSATAGSMtyslvAPKAQRPSPKAPQKV 1176
Cdd:COG3469   171 TTTSASTTPSATTTATATTASGATTPSATTT-----ATTTGPPTPGLPKHV 216
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 1045-1184 5.46e-04

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 43.99  E-value: 5.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1045 SGPAFVQPLLSAGQAPLLAPGQVGVSPVPSPQLPPACTAPGGPVITAFYPGSPAPTSA--PLGPPSQAPPSLVYTVATST 1122
Cdd:NF040712  188 IDPDFGRPLRPLATVPRLAREPADARPEEVEPAPAAEGAPATDSDPAEAGTPDDLASArrRRAGVEQPEDEPVGPGAAPA 267

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 672035060 1123 TPPAAAILPKGPP-----ASATATPAPTSPFPSATAGSMTYSLVAPKAQRPSPKAPQKVKAAIASIP 1184
Cdd:NF040712  268 AEPDEATRDAGEPpapgaAETPEAAEPPAPAPAAPAAPAAPEAEEPARPEPPPAPKPKRRRRRASVP 334
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 1015-1203 7.13e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 44.52  E-value: 7.13e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  1015 GTSSACSQTGTVTSYGPASSV-ALGFTSLGPSGPAFVQPLLSAGQAP--LLAPGQVG--VSPVPSPQLPPACTAPGGPvi 1089
Cdd:pfam05109  409 ATNATTTTHKVIFSKAPESTTtSPTLNTTGFAAPNTTTGLPSSTHVPtnLTAPASTGptVSTADVTSPTPAGTTSGAS-- 486

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  1090 tafyPGSPAPTSAPLGPPSQAPPSLVYTVATSTTPPAAAilpkgPPASATATPAPTSPFPSATAGSMTYSLVAPKAQRPS 1169
Cdd:pfam05109  487 ----PVTPSPSPRDNGTESKAPDMTSPTSAVTTPTPNAT-----SPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATS 557

                          170       180       190
                   ....*....|....*....|....*....|....
gi 672035060  1170 PKAPQKVKAAIASIPVGSFESGTTGRTGPTPRQS 1203
Cdd:pfam05109  558 PTPAVTTPTPNATIPTLGKTSPTSAVTTPTPNAT 591
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 45-151 5.55e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.51  E-value: 5.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060   45 APSQPDPSVQPSEAQQPASHPVASNQ-SKEPAESAAVAHEQPPGGTGGADPGRPPGATCPESPGPGPPLTLGGVDPGKSL 123
Cdd:PRK07764  683 PAPAPAAPAAPAGAAPAQPAPAPAATpPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPP 762

                          90       100
                  ....*....|....*....|....*...
gi 672035060  124 PPTTEEEAPGPPGEPRLDSETESDHDDA 151
Cdd:PRK07764  763 APAPAAAPAAAPPPSPPSEEEEMAEDDA 790
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
646-788 5.93e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 41.37  E-value: 5.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  646 SAPAPSLAYGAPAAPLCRPAATMVTNVVRPVSSTPVPIASKPFPTSGRAEASSNDTVGARTEMGTGSRVPGGSPLGVSLV 725
Cdd:PRK07003  383 PGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGDAPVPAKANARASADSR 462

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672035060  726 YSDKKSAAATSPAPHLVAGPllgtvgKAPATVTNllvgtpgygAPASPAVQFIAQGAPGSATP 788
Cdd:PRK07003  463 CDERDAQPPADSGSASAPAS------DAPPDAAF---------EPAPRAAAPSAATPAAVPDA 510
rad23 TIGR00601
UV excision repair protein Rad23; All proteins in this family for which functions are known ...
 1096-1167 7.50e-03

UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273167 [Multi-domain]  Cd Length: 378  Bit Score: 40.65  E-value: 7.50e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672035060  1096 SPAPTSAPLGPPSQAPPSLVYTVATSTTPPAAAILPKGPPASATATPAPTSPFPSATA-GSMTYSLVAPKAQR 1167
Cdd:TIGR00601   84 VAPPAATPTSAPTPTPSPPASPASGMSAAPASAVEEKSPSEESATATAPESPSTSVPSsGSDAASTLVVGSER 156
 
Name Accession Description Interval E-value
HMG-box_CIC-like cd21990
high mobility group (HMG)-box found in protein capicua (CIC) and similar proteins; CIC is a ...
 199-276 1.42e-59

high mobility group (HMG)-box found in protein capicua (CIC) and similar proteins; CIC is a transcriptional repressor which plays a role in the development of the central nervous system (CNS). In concert with ATXN1 and ATXN1L, CIC is involved in brain development.


Pssm-ID: 438806 [Multi-domain]  Cd Length: 78  Bit Score: 198.45  E-value: 1.42e-59
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672035060  199 HIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKWCNKDRKK 276
Cdd:cd21990     1 HIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPEEKQKYHDLAFQVKEAHFKAHPDWKWCSKDRKK 78
HMG-box_HBP2 cd21989
high mobility group (HMG)-box found in HMG box-containing protein 2 (HBP2) and similar ...
 201-269 2.85e-34

high mobility group (HMG)-box found in HMG box-containing protein 2 (HBP2) and similar proteins; HBP2, also called HMG box transcription factor BBX, or Bobby sox homolog, is a transcription factor that is necessary for cell cycle progression from the G1 to S phase.


Pssm-ID: 438805 [Multi-domain]  Cd Length: 69  Bit Score: 125.98  E-value: 2.85e-34
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 672035060  201 RRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKW 269
Cdd:cd21989     1 RRPMNAFLLFCKRHRSLVRERHPRLDNRGITKILGDWWAVLDPDEKQKYTDLAKQYKEAFMKANPNFKW 69
HMG-box_SOX cd22004
high mobility group (HMG)-box found in sex-determining region Y (SRY)-box (SOX) family ...
 199-272 1.75e-22

high mobility group (HMG)-box found in sex-determining region Y (SRY)-box (SOX) family transcription factors; The SOX gene family of transcription factors are characterized by the evolutionarily conserved SRY-type HMG box, which is a DNA binding domain that binds the minor groove of DNA on a common consensus site, (A/T)(A/T)CAA(A/T)G but with different levels of efficiency. Members include SRY and its homologs identified in mammals that can be subdivided into 8 groups (A, B1, B2, C, D, E, F, G, H). They are involved in embryonic development, regulating processes such as cell differentiation, maintenance of stemness, sex determination, and development of the central nervous, haematopoietic and other organ systems. The SOX gene family has a crucial role in carcinogenesis and cancer progression.


Pssm-ID: 438820 [Multi-domain]  Cd Length: 75  Bit Score: 92.61  E-value: 1.75e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 672035060  199 HIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKWCNK 272
Cdd:cd22004     1 HIKRPMNAFMVWSQQERKKIAKQNPKLHNSEISKILGKEWKKLTEEEKRPYVEEAERLREEHKKEYPDYKYRPR 74
HMG-box_ROX1-like cd01389
high mobility group (HMG)-box found in Saccharomyces cerevisiae repressor ROX1 and similar ...
 200-268 4.42e-22

high mobility group (HMG)-box found in Saccharomyces cerevisiae repressor ROX1 and similar proteins; This family includes class I members of the HMG-box superfamily of DNA-binding proteins, including Saccharomyces cerevisiae repressor ROX1, Schizosaccharomyces pombe mating-type M-specific polypeptide Mc (mat-Mc), Schizosaccharomyces pombe transcription factor ste11, Podospora anserina MAT+ sexual cell fertilization-promoting factor (FPR1), Podospora anserina sporulation minus regulator 2 (SMR2) and Candida albicans repressor of filamentous growth 1 (RFG1). These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. ROX1, also called heme-dependent repression factor, or hypoxic function repressor, is a transcription factor that represses the expression of HEM13, COX5B, ANB1, CYC7 or AAC3. It binds to the DNA sequence 5'-RRRTAACAAGAG-3'. mat-Mc belongs to the mating type protein family, which contains sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. mat-Mc is a positive regulator of MFM genes and is required for conjugation and efficient meiosis. Its HMG box recognizes the DNA sequence 5'-AACAAAG-3'. Ste11 is a key transcription factor for sexual development. It activates the transcription of the matp, matm, mei2, mfm, ste6 and rgs1 genes. It binds specifically to a DNA fragment carrying a 10-base motif 5'-TTCTTTGTTY-3'. FPR1 controls fertilization, probably by determining the mating type. SMR2 is a transcription factor that is required for post-fertilization events. It is required for the developmental events that occur in the female organ after fertilization. RFG1 is a transcription regulator that functions in both the positive and negative regulation of filamentous growth, depending upon environmental conditions.


Pssm-ID: 438791 [Multi-domain]  Cd Length: 72  Bit Score: 91.49  E-value: 4.42e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 672035060  200 IRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWK 268
Cdd:cd01389     1 IPRPPNAFILFRKEKHKQLRAQNPGLTNSEISKIIGKMWKNLSEEEKEPYKELAEEEKEEHKLKYPDYK 69
HMG-box_SoxH_SOX30 cd22033
high mobility group (HMG)-box found in sex determining region Y (SRY)-box 30 (SOX30) and ...
 199-270 2.59e-20

high mobility group (HMG)-box found in sex determining region Y (SRY)-box 30 (SOX30) and similar proteins; SOX-30 is a crucial transcription factor that controls the transition from a late meiotic to a post-meiotic gene expression program and subsequent round spermatid development. It specially prevents Wnt-signaling to suppress metastasis. SOX-30 binds to the DNA sequence 5'-ACAAT-3' and shows a preference for guanine residues surrounding this core motif. SOX-30 is the only member of the group H of SRY-related high-mobility group (HMG) box (Sox) transcription factors.


Pssm-ID: 438842 [Multi-domain]  Cd Length: 75  Bit Score: 86.32  E-value: 2.59e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 672035060  199 HIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKWC 270
Cdd:cd22033     1 HIKRPMNAFMVWARIHRPALAKANPNANNADISVQLGEEWNKLTEEQKKPYYDEAQKLKEQHRKEHPGWVYQ 72
HMG smart00398
high mobility group;
199-268 6.12e-19

high mobility group;


Pssm-ID: 197700 [Multi-domain]  Cd Length: 70  Bit Score: 82.36  E-value: 6.12e-19
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060    199 HIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWK 268
Cdd:smart00398    1 KPKRPMSAFMLFSQENRAKIKAENPDLSNAEISKKLGERWKLLSEEEKAPYEEKAKKDKERYEEEMPEYK 70
HMG-box_HBP1 cd21988
high mobility group (HMG)-box found in HMG box-containing protein 1 (HBP1) and similar ...
 201-268 1.24e-18

high mobility group (HMG)-box found in HMG box-containing protein 1 (HBP1) and similar proteins; HBP1, also called HMG box transcription factor 1, or high mobility group box transcription factor 1, is a transcriptional repressor that binds to the promoter region of target genes. It plays a role in the regulation of the cell cycle and the Wnt pathway. HBP1 binds preferentially to the sequence 5'-TTCATTCATTCA-3'.


Pssm-ID: 438804 [Multi-domain]  Cd Length: 69  Bit Score: 81.35  E-value: 1.24e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 672035060  201 RRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPD-WK 268
Cdd:cd21988     1 KRPMNAFMLFAKKYRVEYTQMHPGKDNRAISVILGDRWKKMKNEERRVYTLEAKALAEEHKRLHPDcWK 69
HMG-box_SoxA_SoxB_SoxG cd22028
high mobility group (HMG)-box found in group A, group B and group G of SRY-related ...
 199-276 1.37e-18

high mobility group (HMG)-box found in group A, group B and group G of SRY-related high-mobility group (HMG) box (Sox) transcription factors; This subfamily includes SoxA, SoxB, and SoxG proteins. SRY is the only member of group A SRY-related high-mobility group (HMG) box (Sox) transcription factors. SRY, also called testis-determining factor, is a transcriptional regulator that controls a genetic switch in male development. It promotes DNA bending and is also involved in pre-mRNA splicing. The SRY HMG box recognizes DNA by partial intercalation in the minor groove. It binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. SoxB transcription factors play critical roles in the regulation of neurogenesis. They can be divided into two main subgroups, SoxB1 (Sox-1/Sox-2/Sox-3) and SoxB2 (SOX-14/SOX-21). SoxB1 proteins suppress neurogenesis by maintaining neural cells in an undifferentiated state. SoxB2 proteins may have the opposite activity and promote neuronal differentiation. SOX-5 is the only member of group G Sox transcription factors. It is also called SOX-12, SOX-20, SOX-26, or SOX-27. SOX-5 is a crucial transcription factor involved in the regulation of embryonic development and in cell fate determination. It binds to the 5'-AACAAT-3' sequence. SOX-15 can be a tumor suppressor in multiple cancer types.


Pssm-ID: 438837 [Multi-domain]  Cd Length: 76  Bit Score: 81.63  E-value: 1.37e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672035060  199 HIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKWcnKDRKK 276
Cdd:cd22028     1 RVKRPMNAFMVWSREQRRKIAQENPKMHNSEISKRLGAEWKQLSEDEKRPFIDEAKRLRAQHMKEHPDYKY--RPRRK 76
HMG_box pfam00505
HMG (high mobility group) box;
200-267 1.64e-17

HMG (high mobility group) box;


Pssm-ID: 459837 [Multi-domain]  Cd Length: 68  Bit Score: 78.04  E-value: 1.64e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672035060   200 IRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDW 267
Cdd:pfam00505    1 PKRPMSAFFLFSKEQRAKLKAENPGLKNAEISKILGEKWKALSEEEKKPYEEKAEKEKARYEKEHPEY 68
HMG-box_EGL13-like cd22042
high mobility group (HMG)-box found in Caenorhabditis elegans protein egg laying defective 13 ...
 199-269 3.25e-17

high mobility group (HMG)-box found in Caenorhabditis elegans protein egg laying defective 13 (EGL-13) and similar proteins; EGL-13 may act as a transcription factor that is required for uterine cell fate decisions in Caenorhabditis elegans. It controls genes required for the specification and differentiation of O(2) and CO(2)-sensing neurons and for maintaining URX sensory neuronal cell fate.


Pssm-ID: 438848 [Multi-domain]  Cd Length: 78  Bit Score: 77.63  E-value: 3.25e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672035060  199 HIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKW 269
Cdd:cd22042     2 HIKRPMNAFMVWAKDERRKILKACPDMHNSNISKILGAKWKAMSNAEKQPYYEEQSRLSKLHMEKHPDYRY 72
HMG-box_SF cd00084
high mobility group (HMG)-box domain superfamily; The High Mobility Group (HMG)-box is found ...
 202-260 1.76e-16

high mobility group (HMG)-box domain superfamily; The High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenetically distinct groups of Class I proteins bind DNA in a sequence specific fashion and contain a single HMG box. One group (SOX-TCF) includes transcription factors, TCF-1, -3, -4, and also SRY and LEF-1, which bind four-way DNA junctions and duplex DNA targets. The second group (MATA) includes fungal mating type gene products MC, MATA1 and Ste11. Class II and III proteins (HMGB-UBF) bind DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone chromosomal proteins, HMG1 and HMG2, which bind to bent or distorted DNA such as four-way DNA junctions, synthetic DNA cruciforms, kinked cisplatin-modified DNA, DNA bulges, cross-overs in supercoiled DNA, and can cause looping of linear DNA. Class III members include nucleolar and mitochondrial transcription factors, UBF and mtTF1, which bind four-way DNA junctions.


Pssm-ID: 438789 [Multi-domain]  Cd Length: 59  Bit Score: 74.86  E-value: 1.76e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 672035060  202 RPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAH 260
Cdd:cd00084     1 RPLSAYLLFSKEKRPKLKKENPDLSFTEISKLLGERWKELSEEEKQPYEEKAKEDKERY 59
HMG-box_SoxB cd01388
high mobility group (HMG)-box found in group B SRY-related high-mobility group (HMG) box (Sox) ...
 198-279 3.04e-16

high mobility group (HMG)-box found in group B SRY-related high-mobility group (HMG) box (Sox) transcription factors; SoxB transcription factors play critical roles in the regulation of neurogenesis. They can be divided into two main subgroups, SoxB1 (Sox-1/Sox-2/Sox-3) and SoxB2 (SOX-14/SOX-21). SoxB1 proteins suppress neurogenesis by maintaining neural cells in an undifferentiated state. SoxB2 proteins may have the opposite activity and promote neuronal differentiation. SOX-1 is involved in the regulation of embryonic development and cell fate determination. It also acts as a tumor suppressor that plays an anti-tumorigenicity role in different cells and its expression is inhibited in a variety of cancers. SOX-2 plays an important role in various phases of embryonic development, including cell fate and differentiation. Its overexpression and gene amplification may be associated with tumor aggression and metastasis in various cancer types, including breast, prostate, lung, ovarian and colon cancer. SOX-3 is required during the formation of the hypothalamic-pituitary axis. It plays a role in both normal neural development and carcinogenesis. SOX-14, also called SOX-28, acts as a negative regulator of transcription. It is mainly involved in the regulation of neural development. It can also promote proliferation and invasion capacity of cervical cancer cells by activating the Wnt/beta-catenin pathway. SOX-21, also called SOX-A, or SOX-25, promotes the progression of vertebrate neurogenesis.


Pssm-ID: 438790 [Multi-domain]  Cd Length: 80  Bit Score: 74.94  E-value: 3.04e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  198 DHIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKWcnKDRKKS 277
Cdd:cd01388     1 DRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSEAEKRPFIDEAKRLRALHMKEHPDYKY--RPRRKT 78


                  ..
gi 672035060  278 SS 279
Cdd:cd01388    79 KT 80
HMG-box_SoxD cd22030
high mobility group (HMG)-box found in group D SRY-related high-mobility group (HMG) box (Sox) ...
 199-276 1.84e-15

high mobility group (HMG)-box found in group D SRY-related high-mobility group (HMG) box (Sox) transcription factors; SoxD transcription factors includes three members, Sox5, Sox6, and Sox13. They function as important transcriptional regulators of glial development in the central nervous system. SoxD proteins influence multiple stages of oligodendrocyte development and modulate SoxE protein function. This subfamily also contains SoxD transcription factor homolog EGL-13, which specifies distinct O2 and CO2 sensory neuron fates in Caenorhabditis elegans. SOX-5 plays important roles in various cancer types. It binds specifically to the DNA sequence 5'-AACAAT-3'. SOX-6 plays a key role in cell proliferation, differentiation, and cell fate determination, as well as neurogenesis and skeleton formation. It is a tumor suppressor and downregulated in various cancers. SOX-6 binds specifically to the DNA sequence 5'-AACAAT-3'. SOX-13, also called Islet cell antigen 12 (ICA12), or type 1 diabetes auto-antigen ICA12, modulates T cell specification and is an autoimmune antigen. It binds to the sequence 5'-AACAAT-3'.


Pssm-ID: 438839 [Multi-domain]  Cd Length: 77  Bit Score: 72.73  E-value: 1.84e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672035060  199 HIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKWcnKDRKK 276
Cdd:cd22030     1 HIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKSMSNQEKQPYYEEQARLSKQHLEKYPDYKY--KPRPK 76
HMG-box_SoxE cd22031
high mobility group (HMG)-box found in group E SRY-related high-mobility group (HMG) box (Sox) ...
 199-269 2.60e-15

high mobility group (HMG)-box found in group E SRY-related high-mobility group (HMG) box (Sox) transcription factors; SoxE transcription factors includes three members: Sox8, Sox9, and Sox10. They function as important transcriptional regulators of neural differentiation and nervous system development. They regulate mammalian development directing sex determination, gliogenesis, pancreas specification and neural crest development. SOX-8 is specifically expressed by M cells in the intestinal epithelium. It acts as a transcription factor necessary for the maintenance of spermatogenesis. It may play a role in central nervous system, limb and facial development. SOX-9 is involved in cell differentiation, sex determination, and tumorigenesis. It plays a role in chondrocyte differentiation and skeletal development. SOX-10 plays a central role in the development of melanocytes and glial cells from neural crest precursors.


Pssm-ID: 438840 [Multi-domain]  Cd Length: 75  Bit Score: 72.04  E-value: 2.60e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672035060  199 HIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKW 269
Cdd:cd22031     1 HVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLSESEKRPFIEEAERLRVQHKKDHPDYKY 71
HMG-box_SoxF cd22032
high mobility group (HMG)-box found in group F SRY-related high-mobility group (HMG) box (Sox) ...
 199-269 8.06e-15

high mobility group (HMG)-box found in group F SRY-related high-mobility group (HMG) box (Sox) transcription factors; SoxF transcription factors includes three members: Sox7, Sox17, and Sox18. They regulate endothelial cell fate as well as development and differentiation of the developing heart, blood cells, and lymphatic vessels.


Pssm-ID: 438841 [Multi-domain]  Cd Length: 76  Bit Score: 70.91  E-value: 8.06e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672035060  199 HIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKW 269
Cdd:cd22032     1 RIRRPMNAFMVWAKDERKRLADENPDLHNAELSKMLGKKWKSLSLAEKRPFVEEAERLRVQHMQDYPNYKY 71
HMG-box_TCF7-like cd21996
high mobility group (HMG)-box found in the transcription factor 7 (TCF-7)-like family; The ...
 199-276 1.49e-14

high mobility group (HMG)-box found in the transcription factor 7 (TCF-7)-like family; The TCF7-like family includes TCF-7, TCF7-like 1 (TF7L1), lymphoid enhancer-binding factor 1 (LEF-1), and similar proteins. TCF-7, also called T-cell-specific transcription factor 1, or T-cell factor 1 (TCF-1), is a T lymphocyte-specific transcriptional activator involved in T-cell lymphocyte differentiation. It is necessary for the survival of CD4(+) CD8(+) immature thymocytes. It binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. TF7L1, also called HMG box transcription factor 3 (TCF-3), participates in the Wnt signaling pathway. It binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. TF7L2, also called HMG box transcription factor 4, or T-cell-specific transcription factor 4, or T-cell factor 4, or TCF-4, participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. It acts as a repressor in the absence of CTNNB1, and it activates transcription from promoters with several copies of the TCF motif 5'-CCTTTGATC-3' in the presence of CTNNB1. LEF-1, also called T cell-specific transcription factor 1-alpha (TCF1-alpha), is a transcription factor that binds DNA in a sequence-specific manner. It may participate in the Wnt signaling pathway. All family members contain one HMG-box domain.


Pssm-ID: 438812 [Multi-domain]  Cd Length: 85  Bit Score: 70.44  E-value: 1.49e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  199 HIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWK-----WCNKD 273
Cdd:cd21996     1 HIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSardnyGKKKK 80


                  ...
gi 672035060  274 RKK 276
Cdd:cd21996    81 RKR 83
HMG-box_SoxC cd22029
high mobility group (HMG)-box found in group C SRY-related high-mobility group (HMG) box (Sox) ...
 199-276 4.21e-14

high mobility group (HMG)-box found in group C SRY-related high-mobility group (HMG) box (Sox) transcription factors; SoxC transcription factors includes three members: SOX4, SOX11 and SOX12. They play key roles, often in redundancy, in multiple developmental pathways, including neurogenesis and skeletogenesis. SOX-4 is a transcriptional activator that promotes neuronal differentiation both in the adult and embryonic neural progenitors. It binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif. SOX-4 is abnormally expressed in various cancers. SOX-11 is a neural transcriptional factor involved in precursor survival, neuronal fate determination, migration and morphogenesis. SOX-12, also called SOX-22, is a transcription factor essential for embryonic development and cell fate determination. It binds to the sequence 5'-AACAAT-3'.


Pssm-ID: 438838 [Multi-domain]  Cd Length: 76  Bit Score: 68.62  E-value: 4.21e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672035060  199 HIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKWcnKDRKK 276
Cdd:cd22029     1 HIKRPMNAFMVWSQIERRKIMEQQPDMHNAEISKRLGKRWKLLSDSEKIPFIEEAERLRLLHMQEYPDYKY--RPRKK 76
HMG-box_SoxF_SOX7 cd22046
high mobility group (HMG)-box found in sex determining region Y (SRY)-box 7 (SOX7) and similar ...
 190-276 4.31e-14

high mobility group (HMG)-box found in sex determining region Y (SRY)-box 7 (SOX7) and similar proteins; SOX-7 is an endothelial-associated transcription factor that acts as a tumor suppressor in a number of cancer types. It binds the DNA sequence 5'-AACAAT-3'. SOX-7 belongs to the group F of SRY-related high-mobility group (HMG) box (Sox) transcription factors.


Pssm-ID: 438849 [Multi-domain]  Cd Length: 88  Bit Score: 69.33  E-value: 4.31e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  190 RSP-NKREKDHIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWK 268
Cdd:cd22046     1 RSPgEKGSEPRIRRPMNAFMVWAKDERKRLAVQNPDLHNAELSKMLGKSWKALTPSQKRPYVEEAERLRVQHMQDYPNYK 80


                  ....*...
gi 672035060  269 WCNKDRKK 276
Cdd:cd22046    81 YRPRRKKQ 88
HMG-box_SoxF_SOX18 cd22048
high mobility group (HMG)-box found in sex determining region Y (SRY)-box 18 (SOX18) and ...
 200-276 4.94e-14

high mobility group (HMG)-box found in sex determining region Y (SRY)-box 18 (SOX18) and similar proteins; SOX-18 is a transcription factor involved in the development of cardiovascular and lymphatic vessels during embryonic development. It binds to the consensus sequence 5'-AACAAAG-3' and is able to trans-activate transcription via this site. SOX-18 belongs to the group F of SRY-related high-mobility group (HMG) box (Sox) transcription factors.


Pssm-ID: 438851 [Multi-domain]  Cd Length: 80  Bit Score: 68.94  E-value: 4.94e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 672035060  200 IRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKWCNKDRKK 276
Cdd:cd22048     4 IRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGQSWKSLSAAEKRPFVEEAERLRVQHLQDHPNYKYRPRRKKQ 80
HMG-box_SoxF_SOX17 cd22047
high mobility group (HMG)-box found in sex determining region Y (SRY)-box 17 (SOX17) and ...
 200-269 3.43e-13

high mobility group (HMG)-box found in sex determining region Y (SRY)-box 17 (SOX17) and similar proteins; SOX-17 is a developmental transcription regulator involved in endoderm formation, angiogenesis, and carcinogenesis. It acts as a tumor suppressor and modulates WNT signaling. SOX-17 binds target promoter DNA and bends the DNA. It binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3'. SOX-17 belongs to the group F of SRY-related high-mobility group (HMG) box (Sox) transcription factors.


Pssm-ID: 438850 [Multi-domain]  Cd Length: 81  Bit Score: 66.26  E-value: 3.43e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  200 IRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKW 269
Cdd:cd22047     7 IRRPMNAFMVWAKDERKRLAQQNPDLHNAELSKMLGKSWKALTLAEKRPFVEEAERLRVQHMQDHPNYKY 76
PHA03247 PHA03247
large tegument protein UL36; Provisional
 732-1274 5.60e-13

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 74.59  E-value: 5.60e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  732 AAATSPAPHLVAGPLLGTVGKAPATVTNLLVGTPGYGAPASPAVQFIAQGAPGsatpagSGASAGSGPNGPVPLGILQPG 811
Cdd:PHA03247 2445 AGLAADGDPFFARTILGAPFSLSLLLGELFPGAPVYRRPAEARFPFAAGAAPD------PGGGGPPDPDAPPAPSRLAPA 2518

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  812 ALGKAGGITQVQYILPTLPQQLQVAPAPAPAPGTKAAAPSGPAPTTSIRFTLP-PGTSTNGKVLAATAPTAGIPILQSVP 890
Cdd:PHA03247 2519 ILPDEPVGEPVHPRMLTWIRGLEELASDDAGDPPPPLPPAAPPAAPDRSVPPPrPAPRPSEPAVTSRARRPDAPPQSARP 2598

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  891 SAP-PPKAQSVSPVQATPSGGSAQLLPGKVLVPLAAPSMSVRGGGAGQPLPLVSSPFSVPVQNGAQQPSKIIQLTPVPVS 969
Cdd:PHA03247 2599 RAPvDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASS 2678

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  970 TPSGLVPPLSPATMPGPTSQPQKVLLPSSTRITYVQSAGGHTLPLGTSSAcsqtgtvtsygPASSVALGFTSLGPSGPAf 1049
Cdd:PHA03247 2679 PPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAA-----------RQASPALPAAPAPPAVPA- 2746

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1050 vQPLLSAGQAPLLAPGQVGVSPVPSPQLPPACTAPGGPVITAFYPGSPAPTSAPLGPPSQAPPSLVYTVATSTTPPAAAI 1129
Cdd:PHA03247 2747 -GPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPA 2825

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1130 LPKGPPASATATPAPTSPFPSATAGSMTYSLV--APKAQRPSPKAPQKVKAAIASIPVGSFESgttgrtgPTPRQSLDSg 1207
Cdd:PHA03247 2826 GPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVApgGDVRRRPPSRSPAAKPAAPARPPVRRLAR-------PAVSRSTES- 2897

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 672035060 1208 varePAAPESELEGQPTPPAPPPPTETWPPTARSSPPPPLPAEERPGTKGPETASKFPSSSSDWRVP 1274
Cdd:PHA03247 2898 ----FALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVP 2960
HMG-box_SoxG_SOX15 cd22035
high mobility group (HMG)-box found in sex determining region Y (SRY)-box 15 (SOX15) and ...
 198-277 6.73e-13

high mobility group (HMG)-box found in sex determining region Y (SRY)-box 15 (SOX15) and similar proteins; SOX-15, also called SOX-12, SOX-20, SOX-26, or SOX-27, is a crucial transcription factor involved in the regulation of embryonic development and in cell fate determination. It binds to the 5'-AACAAT-3' sequence. SOX-15 can be a tumor suppressor in multiple cancer types. SOX-5 is the only member of group G SRY-related high-mobility group (HMG) box (Sox) transcription factors.


Pssm-ID: 438844 [Multi-domain]  Cd Length: 84  Bit Score: 65.87  E-value: 6.73e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  198 DHIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKWcnKDRKKS 277
Cdd:cd22035     6 EKVKRPMNAFMVWSSAQRRQMAQEHPKMHNSEISKRLGAAWKLLPEAEKRPFVEEAKRLRARHMRDYPDYKY--RPRRKG 83
HMG-box_SoxC_SOX12 cd22038
high mobility group (HMG)-box found in sex determining region Y (SRY)-box 12 (SOX12) and ...
 194-277 3.69e-11

high mobility group (HMG)-box found in sex determining region Y (SRY)-box 12 (SOX12) and similar proteins; SOX-12, also called SOX-22, is a transcription factor essential for embryonic development and cell fate determination. It binds to the sequence 5'-AACAAT-3'. SOX-12 belongs to the group C of SRY-related high-mobility group (HMG) box (Sox) transcription factors.


Pssm-ID: 438847 [Multi-domain]  Cd Length: 88  Bit Score: 60.85  E-value: 3.69e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  194 KREKDHIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKWcnKD 273
Cdd:cd22038     6 KTPSGHIKRPMNAFMVWSQIERRKIMEQWPDMHNAEISKRLGRRWKLLQDYEKIPFIKEAERLRLKHMADYPDYKY--RP 83


                  ....
gi 672035060  274 RKKS 277
Cdd:cd22038    84 RKKS 87
HMG-box_SoxA_SRY cd22034
high mobility group (HMG)-box found in sex-determining region Y protein (SRY) and similar ...
 197-276 2.30e-10

high mobility group (HMG)-box found in sex-determining region Y protein (SRY) and similar proteins; SRY, also called testis-determining factor, is a transcriptional regulator that controls a genetic switch in male development. It promotes DNA bending and is also involved in pre-mRNA splicing. The SRY HMG box recognizes DNA by partial intercalation in the minor groove. It binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. SRY is the only member of group A SRY-related high-mobility group (HMG) box (Sox) transcription factors.


Pssm-ID: 438843 [Multi-domain]  Cd Length: 85  Bit Score: 58.49  E-value: 2.30e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  197 KDHIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKWCNKDRKK 276
Cdd:cd22034     2 QDRVKRPMNAFIVWSRDQRRKMALENPRMRNSEISKQLGYQWKMLTEAEKWPFFQEAQKLQAMHREKYPNYKYRPRRKAK 81
HMG-box_NHP6-like cd01390
high mobility group (HMG)-box found in Saccharomyces cerevisiae non-histone chromosomal ...
 187-260 2.54e-10

high mobility group (HMG)-box found in Saccharomyces cerevisiae non-histone chromosomal proteins NHP6A, NHP6B and similar proteins; This subfamily includes Saccharomyces cerevisiae high-mobility-group proteins NHP6A and its closely related paralog NHP6B. NHP6A and NHP6B seem to be functionally redundant. They are DNA-binding proteins that induce severe bending of DNA and are required for DNA-binding by the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. They augment the fidelity of transcription by RNA polymerase III independently of any role in the FACT complex. They may also play essential roles in transcriptional initiation fidelity of some but not all tRNA genes.


Pssm-ID: 438792 [Multi-domain]  Cd Length: 81  Bit Score: 58.15  E-value: 2.54e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 672035060  187 KDGRSPNKREKDHIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAH 260
Cdd:cd01390     1 KKKKGRKKKDPNAPKRGLSAYMFFSQDNREKVKEENPDATFGEVGKLLGEKWKELSEEEKAPYEEKAAKDKKRY 74
HMG-box_SoxC_SOX4 cd22036
high mobility group (HMG)-box found in sex determining region Y (SRY)-box 4 (SOX4) and similar ...
 199-276 4.63e-10

high mobility group (HMG)-box found in sex determining region Y (SRY)-box 4 (SOX4) and similar proteins; SOX-4 is a transcriptional activator that promotes neuronal differentiation both in the adult and embryonic neural progenitors. It binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif. SOX-4 is abnormally expressed in various cancers. SOX-4 belongs to group C SRY-related high-mobility group (HMG) box (Sox) transcription factors.


Pssm-ID: 438845 [Multi-domain]  Cd Length: 79  Bit Score: 57.45  E-value: 4.63e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672035060  199 HIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKWcnKDRKK 276
Cdd:cd22036     2 HIKRPMNAFMVWSQIERRKIMEQSPDMHNAEISKRLGKRWKLLKDSDKIPFIREAERLRLKHMADYPDYKY--RPRKK 77
HMG-box_SoxC_SOX11 cd22037
high mobility group (HMG)-box found in sex determining region Y (SRY)-box 11 (SOX11) and ...
 194-279 6.37e-10

high mobility group (HMG)-box found in sex determining region Y (SRY)-box 11 (SOX11) and similar proteins; SOX-11 is a neural transcriptional factor involved in precursor survival, neuronal fate determination, migration and morphogenesis. SOX-11 belongs to group C SRY-related high-mobility group (HMG) box (Sox) transcription factors.


Pssm-ID: 438846 [Multi-domain]  Cd Length: 92  Bit Score: 57.41  E-value: 6.37e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  194 KREKDHIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKWCNKD 273
Cdd:cd22037     6 KTATGHIKRPMNAFMVWSKIERRKIMEQSPDMHNAEISKRLGKRWKMLKDSEKIPFIREAERLRLKHMADYPDYKYRPRK 85


                  ....*.
gi 672035060  274 RKKSSS 279
Cdd:cd22037    86 KPKVDP 91
HMG-box_SSRP1-like cd21994
high mobility group (HMG)-box found in structure-specific recognition protein 1 (SSRP1) and ...
 202-268 8.75e-09

high mobility group (HMG)-box found in structure-specific recognition protein 1 (SSRP1) and similar proteins; SSRP1, also called FACT complex subunit SSRP1, chromatin-specific transcription elongation factor 80 kDa subunit, facilitates chromatin transcription complex 80 kDa subunit (FACT 80 kDa subunit or FACTp80), facilitates chromatin transcription complex subunit SSRP1, recombination signal sequence recognition protein 1, or T160, is a factor that facilitates transcript elongation through nucleosomes. It is a component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication, and DNA repair.


Pssm-ID: 438810 [Multi-domain]  Cd Length: 67  Bit Score: 53.46  E-value: 8.75e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 672035060  202 RPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWK 268
Cdd:cd21994     1 RPMSAYMLWLNENREKIKKENPGISVTEISKKAGEIWKELDEEDKEKWEQKAEKAKERYDKAMKEYK 67
HMG-box_HMG20 cd21980
high mobility group (HMG)-box found in the high mobility group protein 20 (HMG20) subfamily; ...
 201-258 1.14e-08

high mobility group (HMG)-box found in the high mobility group protein 20 (HMG20) subfamily; The HMG20 subfamily includes HMG20A and HMG20B. HMG20A, also called HMG box-containing protein 20A, HMG domain-containing protein 1, HMG domain-containing protein HMGX1, HMGXB1, or iBRAF, is a chromatin-associated protein involved in neuronal differentiation and maturation. It is required for SNAI1-mediated epithelial to mesenchymal transition. HMG20A acts as an inhibitor of HMG20B. HMG20B, also called SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related, SMARCE1-related protein (SMARCE1R), BRCA2-associated factor 35 (BRAF35), HMG box-containing protein 20B, HMG domain-containing protein 2, HMG domain-containing protein HMGX2, Sox-like transcriptional factor, or structural DNA-binding protein BRAF35, is a DNA binding factor that acts as a repressor of erythroid differentiation. It is required for correct progression through the G2 phase of the cell cycle and entry into mitosis. It is also required for RCOR1/CoREST mediated repression of neuronal specific gene promoters. HMG20B is a core subunit of the Lys-specific demethylase 1/REST co-repressor 1 (LSD1-CoREST) histone demethylase complex. Both HMG20A and HMG20B contain one HMG-box.


Pssm-ID: 438796 [Multi-domain]  Cd Length: 81  Bit Score: 53.32  E-value: 1.14e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 672035060  201 RRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKE 258
Cdd:cd21980     3 KAPLTGYVRFLNERREKLRAENPDLSFPEITKILGAEWSSLSAEEKQKYLDEAEKDKE 60
HMG-box_ABF2_IXR1-like_rpt2 cd22012
second high mobility group (HMG)-box found in Saccharomyces cerevisiae mitochondrial ...
 202-251 3.54e-08

second high mobility group (HMG)-box found in Saccharomyces cerevisiae mitochondrial ARS-binding factor 2 (ABF2), intrastrand cross-link recognition protein (Ixr1) and similar proteins; ABF2 is a close relative of the nuclear, chromosomal high-mobility group protein HMG1 in yeast mitochondria. It specifically binds to the autonomously replicating sequence 1 (ARS1). It might play a positive role in gene expression and replication. Ixr1, also called structure-specific recognition protein (SSRP), is a homolog of the yeast mitochondrial regulator ABF2. It binds to platinated DNA and confers sensitivity to the anticancer drug cisplatin. Both ABF2 and Ixr1 contain two HMG-box domains. This model corresponds to the second one.


Pssm-ID: 438828 [Multi-domain]  Cd Length: 64  Bit Score: 51.52  E-value: 3.54e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 672035060  202 RPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHD 251
Cdd:cd22012     4 RPASAYFLFAKEVRPKLKEENPNEKYTDITKLISEKWRSLDESEKEPYQE 53
HMG-box_AtHMGB6-like_rpt1 cd22006
first high mobility group (HMG)-box found in Arabidopsis thaliana high mobility group B ...
 201-262 9.24e-08

first high mobility group (HMG)-box found in Arabidopsis thaliana high mobility group B protein 6 (HMGB6) and similar proteins; HMGB6, also called nucleosome/chromatin assembly factor group D 06 (or D 6), WRKY transcription factor 53 (WRKY53), or WRKY DNA-binding protein 53, is a master regulator of age-induced leaf senescence. It acts in a complex transcription factor signaling network regulating senescence specific gene expression; hydrogen peroxide might be involved in signal transduction. The subfamily also includes Arabidopsis thaliana HMGB13 (also known as nucleosome/chromatin assembly factor group D 13). Both HMGB6 and HMGB13 contain three HMG-box domains. This model corresponds to the first one.


Pssm-ID: 438822 [Multi-domain]  Cd Length: 68  Bit Score: 50.53  E-value: 9.24e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 672035060  201 RRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFK 262
Cdd:cd22006     1 KKPKTAYFLWCKDQREEVKKENPNADFSEVSKILGAKWKNLSEEEKKPYEEKYKEEKEKYLK 62
PHA03247 PHA03247
large tegument protein UL36; Provisional
 753-1209 1.53e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 56.87  E-value: 1.53e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  753 APATVTNLLVGTPGYGA-PASPAVQfiAQGAPGSATPAGSGASAGSGPNGPvPLGILQPGALGKAGGITQVQYILPTlPQ 831
Cdd:PHA03247 2559 APPAAPDRSVPPPRPAPrPSEPAVT--SRARRPDAPPQSARPRAPVDDRGD-PRGPAPPSPLPPDTHAPDPPPPSPS-PA 2634

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  832 QLQVAPAPAPAPGTKAAAPSGPAPTtsiRFTLPPGTSTNGKVLAATAPTAGipilQSVPSAPPPKAQSVSPVQATPSGGS 911
Cdd:PHA03247 2635 ANEPDPHPPPTVPPPERPRDDPAPG---RVSRPRRARRLGRAAQASSPPQR----PRRRAARPTVGSLTSLADPPPPPPT 2707

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  912 AQLLPGKVLVPLAAPSMSVRGGGAGQPLPLVSSPFSVPvqNGAQQP-SKIIQLTPVPVSTPSGLVPPLSPATMPGPTSQP 990
Cdd:PHA03247 2708 PEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVP--AGPATPgGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTR 2785

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  991 QKV--LLPSSTRITYVQSAGGHTLP-LGTSSACSQTGTVTSYGPASSVALGFTSLGPSGPafVQPLLSAGQAplLAPGQV 1067
Cdd:PHA03247 2786 PAVasLSESRESLPSPWDPADPPAAvLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGP--PPPSLPLGGS--VAPGGD 2861

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1068 GVSPVPSPQLPPACTAPGGPVIT--AFYPGSPAPTSAPLGPPSQAPPSlvytvaTSTTPPAAAILPKGPPASATATPAPT 1145
Cdd:PHA03247 2862 VRRRPPSRSPAAKPAAPARPPVRrlARPAVSRSTESFALPPDQPERPP------QPQAPPPPQPQPQPPPPPQPQPPPPP 2935

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1146 SPFPSATAGSMTYSLVAPKAQRPSPK------APQKVKAAIASIPVGSFESGTTGRTGPTPRQSLDSGVA 1209
Cdd:PHA03247 2936 PPRPQPPLAPTTDPAGAGEPSGAVPQpwlgalVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVS 3005
NHP6B COG5648
Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics];
156-315 1.98e-07

Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics];


Pssm-ID: 227935 [Multi-domain]  Cd Length: 211  Bit Score: 53.33  E-value: 1.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  156 MSPEIQL--PLPPG-----KRRTQSLSALPKERDSSSEKDGRSPnkrekdhiRRPMNAFMIFSKRHRALVHQRHPNQDNR 228
Cdd:COG5648    28 MSGIRQLhtTLVELekplqQLLTKPRKKTKSKRLVRKKKDPNGP--------KRPLSAYFLYSAENRDEIRKENPKLTFG 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  229 TVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKA-HPDwkwcnkDRKKSSSEAKPASLGLAGGHKETRERSMSETG--- 304
Cdd:COG5648   100 EVGKLLSEKWKELTDEEKEPYYKEANSDRERYQREkEEY------NKKLPNKAPIGPFIENEPKIRPKVEGPSPDKAlve 173

                         170
                  ....*....|..
gi 672035060  305 -TAAAPGVSSEL 315
Cdd:COG5648   174 eTKIISKAWSEL 185
HMG-box_AtHMGB6-like_rpt3 cd22008
third high mobility group (HMG)-box found in Arabidopsis thaliana high mobility group B ...
 192-263 3.13e-07

third high mobility group (HMG)-box found in Arabidopsis thaliana high mobility group B protein 6 (HMGB6) and similar proteins; HMGB6, also called nucleosome/chromatin assembly factor group D 06 (or D 6), WRKY transcription factor 53 (WRKY53), or WRKY DNA-binding protein 53, is a master regulator of age-induced leaf senescence. It acts in a complex transcription factor signaling network regulating senescence specific gene expression; hydrogen peroxide might be involved in signal transduction. The subfamily also includes Arabidopsis thaliana HMGB13 (also known as nucleosome/chromatin assembly factor group D 13). Both HMGB6 and HMGB13 contain three HMG-box domains. This model corresponds to the third one.


Pssm-ID: 438824 [Multi-domain]  Cd Length: 78  Bit Score: 49.57  E-value: 3.13e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 672035060  192 PNKREKdhirrPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKA 263
Cdd:cd22008     7 PNKPKK-----PASSYLLFGKEYRKKLQEERPGANNATVTALISLKWKELGEEEKQVYNDKAAVLMEKYKKE 73
HMG-box_HMGB_rpt2 cd21979
second high mobility group (HMG)-box found in the high mobility group protein B (HMGB) family; ...
 201-262 3.30e-07

second high mobility group (HMG)-box found in the high mobility group protein B (HMGB) family; HMGB proteins are chromatin-associated nuclear proteins that act as architectural factors in nucleoprotein structures, which regulate DNA-dependent processes including transcription. In mammals, four family members are present: HMGB1, HMGB2, HMGB3 and HMGB4. They regulate the expression of a wide range of genes through architectural remodeling of the chromatin structure. HMGB1, also called high mobility group protein 1 (HMG-1), is a prototypical alarmin or damage-associated molecular pattern (DAMP) molecule when released from cells. It plays important roles in the regulation of a wide range of processes, including transcription, replication, DNA repair, and nucleosome formation, in the nucleus. It also plays multiple roles in regulating inflammation and responses to cell and tissue stress. HMGB2, also called high mobility group protein 2 (HMG-2), has been implicated in numerous cellular processes, including proliferation, differentiation, apoptosis, and tumor growth. It acts as a chromatin-associated nonhistone protein involved in transcriptional regulation and nucleic-acid-mediated innate immune responses in mammalian. It binds DNA to stabilize nucleosomes and promote transcription. HMGB3, also called high mobility group protein 2a (HMG-2a), or high mobility group protein 4 (HMG-4), is an X-linked member of HMGB family and functions as a universal sentinel for nucleic acid-mediated innate immune responses. HMGB3 has been implicated in the regulation of cellular proliferation and differentiation, as well as inflammatory response. HMGB4 is expressed by neuronal cells and affects the expression of genes involved in neural differentiation. It is a factor that regulates chromatin and expression of neuronal differentiation markers. The family also includes high mobility group protein B1 pseudogene 1 (HMGB1P1) and nuclear auto-antigen Sp-100. HMGB1P1, also called putative high mobility group protein B1-like 1 (HMGB1L1), or putative high mobility group protein 1-like 1 (HMG-1L1), is an HMG-box containing protein that binds preferentially single-stranded DNA and unwinds double-stranded DNA. Sp-100, also called nuclear dot-associated Sp100 protein, or speckled 100 kDa. It is a tumor suppressor that is a major constituent of the promyelocytic leukemia (PML) bodies, a subnuclear organelle involved in many physiological processes including cell growth, differentiation and apoptosis. Through the regulation of ETS1, Sp-100 may play a role in angiogenesis, controlling endothelial cell motility and invasion. It may also play roles in the regulation of telomeres lengthening, TP53-mediated transcription, FAS-mediated apoptosis, etc. In addition, the family includes Drosophila melanogaster high mobility group protein DSP1 (dDSP1) and similar proteins. dDSP1, also called protein dorsal switch 1, is a Drosophila HMG1 protein that binds preferentially single-stranded DNA and unwinds double-stranded DNA. It converts Dorsal and nuclear factor (NF)-kappa B from transcriptional activators to repressors. Members of the HMGB family contain two HMG-box domains. This model corresponds to the second one.


Pssm-ID: 438795 [Multi-domain]  Cd Length: 71  Bit Score: 48.95  E-value: 3.30e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 672035060  201 RRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFK 262
Cdd:cd21979     4 KRPPSAFFLFCSEHRPKIKGEHPGLSIGDVAKKLGEMWNNTSAKDKQPYEKKAAKLKEKYEK 65
PTZ00199 PTZ00199
high mobility group protein; Provisional
 183-257 5.15e-07

high mobility group protein; Provisional


Pssm-ID: 185511 [Multi-domain]  Cd Length: 94  Bit Score: 49.08  E-value: 5.15e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 672035060  183 SSSEKDGRSPNKREKDHI--RRPMNAFMIFSKRHRALVHQRHPN--QDNRTVSKILGEWWYALGPKEKQKYHDLAFQVK 257
Cdd:PTZ00199    4 KQGKVLVRKNKRKKKDPNapKRALSAYMFFAKEKRAEIIAENPElaKDVAAVGKMVGEAWNKLSEEEKAPYEKKAQEDK 82
HMG-box_ABF2-like_rpt1 cd22010
first high mobility group (HMG)-box found in Saccharomyces cerevisiae mitochondrial ...
 201-267 8.30e-07

first high mobility group (HMG)-box found in Saccharomyces cerevisiae mitochondrial ARS-binding factor 2 (ABF2) and similar proteins; ABF2 is a close relative of the nuclear, chromosomal high-mobility group protein HMG1 in yeast mitochondria. It specifically binds to the autonomously replicating sequence 1 (ARS1). It might play a positive role in gene expression and replication. ABF2 contains two HMG-box domains. This model corresponds to the first one.


Pssm-ID: 438826 [Multi-domain]  Cd Length: 68  Bit Score: 47.92  E-value: 8.30e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 672035060  201 RRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDW 267
Cdd:cd22010     2 KRPLSAYFLYFQEHRSDFVKENPDAKMTEISKIGGDKWKNLSADDKKKYEDDFQRELSEYQKAKAEF 68
PHA03247 PHA03247
large tegument protein UL36; Provisional
 881-1288 1.61e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.40  E-value: 1.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  881 AGIPILQSVPSAPPPKA-QSVSPVQATP--SGGSAQLLPGKVLVPLAAPSMSVRGGGAGQPlPLVSSPFSVPVQNGAQQP 957
Cdd:PHA03247 2548 AGDPPPPLPPAAPPAAPdRSVPPPRPAPrpSEPAVTSRARRPDAPPQSARPRAPVDDRGDP-RGPAPPSPLPPDTHAPDP 2626

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  958 skiiqltPVPVSTPSGLVPPLSPATMPGPTSQPQKVllPSSTRITYVQSAGGHTLPLGTSSACSQTGTVTSYGPASSVAL 1037
Cdd:PHA03247 2627 -------PPPSPSPAANEPDPHPPPTVPPPERPRDD--PAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTS 2697

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1038 GFTSLGPSGPAFVQPLLSAGQAPLLAPGQVGVSPVPSPQLPPACTAPGGPVITAFYPGSPAPTSAPLGPPSQAPPSlvyt 1117
Cdd:PHA03247 2698 LADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPA---- 2773

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1118 vATSTTPPAAAILPKGPPASATATPAPTSPFPSATAGSMTYSLVA------PKAQRPSPKAPQKVKAAIASIPVGSFES- 1190
Cdd:PHA03247 2774 -APAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAAlppaasPAGPLPPPTSAQPTAPPPPPGPPPPSLPl 2852

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1191 -GTTGRTGPTPRQSLDSGVAREPAAPeselegqptppapppptetWPPTARSSPPPPLPAEERPGTKGPETASKFPSSSS 1269
Cdd:PHA03247 2853 gGSVAPGGDVRRRPPSRSPAAKPAAP-------------------ARPPVRRLARPAVSRSTESFALPPDQPERPPQPQA 2913

                         410
                  ....*....|....*....
gi 672035060 1270 DWRVPGLGLESRGEPPTPP 1288
Cdd:PHA03247 2914 PPPPQPQPQPPPPPQPQPP 2932
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
1043-1282 1.65e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 52.96  E-value: 1.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1043 GPSGPAFVQPLLSAGQAPLLAPGQVGVSPVPSPQLPPACTAPGGPV--ITAFYPGSPAPTSAPLGPPSQAPPSLVYTVAT 1120
Cdd:PRK12323  370 GGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAarAVAAAPARRSPAPEALAAARQASARGPGGAPA 449

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1121 STTPPAAAilpkgpPASATATPAPTSPFPSATAGSMTYSLVAPKAQRPSPKAPQKVKAAIASIPVGSFESGTTGRTGPTP 1200
Cdd:PRK12323  450 PAPAPAAA------PAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVA 523

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1201 RQSLDSGVAREPAAPESELEGqptppappppTETWPPTARSSPPPPLPAEERPGTKGPETASKFPsssSDWRVPGLGLES 1280
Cdd:PRK12323  524 ESIPDPATADPDDAFETLAPA----------PAAAPAPRAAAATEPVVAPRPPRASASGLPDMFD---GDWPALAARLPV 590


                  ..
gi 672035060 1281 RG 1282
Cdd:PRK12323  591 RG 592
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 875-1261 2.04e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 52.68  E-value: 2.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  875 AATAPTAGIPILQSVPSAPPPKAQSVSPvQATPSGGSAQLLPGKVLVPLAAPSMSVRGGGAGQPLPLVSSPFSVPVQNGA 954
Cdd:PRK07764  402 AAAAPAAAPAPAAAAPAAAAAPAPAAAP-QPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAP 480

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  955 QQPSKIIQLTPVPVSTPSGLVPPLSPATMPGPTSQPQKVL--LPSSTRIT------YVQSAG--GHTLPLGTSS-----A 1019
Cdd:PRK07764  481 APAPPAAPAPAAAPAAPAAPAAPAGADDAATLRERWPEILaaVPKRSRKTwaillpEATVLGvrGDTLVLGFSTgglarR 560

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1020 CSQTGTVTSYGPASSVALGFT------------SLGPSGPAFVQPLLSAGQAPllAPGQVGVSPVPSPQLPPACTAPGGP 1087
Cdd:PRK07764  561 FASPGNAEVLVTALAEELGGDwqveavvgpapgAAGGEGPPAPASSGPPEEAA--RPAAPAAPAAPAAPAPAGAAAAPAE 638

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1088 VITAFYPGSPAPTSAPLGPPSQAPPSLVYTVATSTTPPAAAilPKGPPASATATPAPTSPFPSATAGSMTYSLVAPKAQR 1167
Cdd:PRK07764  639 ASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPA--APPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADD 716

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1168 PSPKAPQkvkaaiasipvgsfesGTTGRTGPTPRQSLDSGVAREPAAPESELEGQPTPPAPPPPTETWPPTARSSPPPPL 1247
Cdd:PRK07764  717 PAAQPPQ----------------AAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPS 780

                         410
                  ....*....|....
gi 672035060 1248 PAEERPGTKGPETA 1261
Cdd:PRK07764  781 EEEEMAEDDAPSMD 794
HMG_box_2 pfam09011
HMG-box domain; This short 71 residue domain is an HMG-box domain. HMG-box domains mediate ...
 192-267 2.97e-06

HMG-box domain; This short 71 residue domain is an HMG-box domain. HMG-box domains mediate re-modelling of chromatin-structure. Mammalian HMG-box proteins are of two types: those that are non-sequence-specific DNA-binding proteins with two HMG-box domains and a long highly acidic C-tail; and a diverse group of sequence-specific transcription factor-proteins with either a single HMG-box or up to six copies, and no acidic C-tail.


Pssm-ID: 430369 [Multi-domain]  Cd Length: 72  Bit Score: 46.24  E-value: 2.97e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672035060   192 PNKRekdhiRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDW 267
Cdd:pfam09011    1 PNKP-----KRARNAYAFFVQEMIPEHKRQNPVIGFAEVSKLCSERWKNLSEEEKEKYEEMAKEDKNRYDREMGTY 71
HMG-box_AtHMGB6-like_rpt2 cd22007
second high mobility group (HMG)-box found in Arabidopsis thaliana high mobility group B ...
 201-263 5.59e-06

second high mobility group (HMG)-box found in Arabidopsis thaliana high mobility group B protein 6 (HMGB6) and similar proteins; HMGB6, also called nucleosome/chromatin assembly factor group D 06 (or D 6), WRKY transcription factor 53 (WRKY53), or WRKY DNA-binding protein 53, is a master regulator of age-induced leaf senescence. It acts in a complex transcription factor signaling network regulating senescence specific gene expression; hydrogen peroxide might be involved in signal transduction. The subfamily also includes Arabidopsis thaliana HMGB13 (also known as nucleosome/chromatin assembly factor group D 13). Both HMGB6 and HMGB13 contain three HMG-box domains. This model corresponds to the second one.


Pssm-ID: 438823 [Multi-domain]  Cd Length: 68  Bit Score: 45.32  E-value: 5.59e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672035060  201 RRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKA 263
Cdd:cd22007     2 KRPQSAYFLYANDRRAALKEENKNVKITEIAKMLGAEWKNLSDAKKKPYEEKAKKLKEAYLQE 64
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 1041-1203 5.60e-06

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 51.22  E-value: 5.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1041 SLGPSGPAFVQPLLSAGQAPllAPGQVGVSPVPSPQLPPACTAPGGPVITAFYPGSPAPTSAPLG--PPSQAPPslvytv 1118
Cdd:PRK14959  370 SLRPSGGGASAPSGSAAEGP--ASGGAATIPTPGTQGPQGTAPAAGMTPSSAAPATPAPSAAPSPrvPWDDAPP------ 441

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1119 atstTPPAAAILPKGPPASATATPAPTSPFPSATAGSMTYSLVAPKAqrPSPKAPQKVKAAIASIPVGSFESGTTGRTGP 1198
Cdd:PRK14959  442 ----APPRSGIPPRPAPRMPEASPVPGAPDSVASASDAPPTLGDPSD--TAEHTPSGPRTWDGFLEFCQGRNGQGGRLAT 515


                  ....*
gi 672035060 1199 TPRQS 1203
Cdd:PRK14959  516 VLRQA 520
HMG-box_UBF1_rpt4 cd22001
fourth high mobility group (HMG)-box found in upstream-binding factor 1 (UBF1) and similar ...
 198-258 6.67e-06

fourth high mobility group (HMG)-box found in upstream-binding factor 1 (UBF1) and similar proteins; UBF1, also called UBTF, nucleolar transcription factor 1, or auto-antigen NOR-90, is a nucleolar transcription factor that recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element. UBF1 contains six HMG-box domains. This model corresponds to the fourth one.


Pssm-ID: 438817 [Multi-domain]  Cd Length: 66  Bit Score: 45.37  E-value: 6.67e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672035060  198 DHIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKE 258
Cdd:cd22001     1 EKPKRPISAMFIYSKEKRSKLKKKHPELSEQELTRLLAKKYNELPDKKKAKYKKKEALAKA 61
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 853-1219 1.03e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 50.55  E-value: 1.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  853 PAPTTSIRFTLPPGTSTNGKVLAATAPTAGIPilqSVPSAPPPKAQSVSPVQATPSGGSAQLLPGKVLVPLAAPSMSVRG 932
Cdd:PHA03307   80 PANESRSTPTWSLSTLAPASPAREGSPTPPGP---SSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAG 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  933 GGAGQ-PLPLVSSPFSVPVQNGAQQPSKiiqltpvPVSTPSGLVPPLSPATMPGPTSQPqkvllPSSTRITYVQSAGGHT 1011
Cdd:PHA03307  157 ASPAAvASDAASSRQAALPLSSPEETAR-------APSSPPAEPPPSTPPAAASPRPPR-----RSSPISASASSPAPAP 224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1012 LPLGTSSACSQTGTVTSYGPASSvALGFTSLGPSGPAFVQPLLSagqAPLLAPGQVGVSPVPSPQLPPACTAPGGPVITA 1091
Cdd:PHA03307  225 GRSAADDAGASSSDSSSSESSGC-GWGPENECPLPRPAPITLPT---RIWEASGWNGPSSRPGPASSSSSPRERSPSPSP 300

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1092 FYPGSPAPTSAPLGPPSQAPPSLVYTVATSTTPPAAAILPKGPPASATATPAPTSPFPSATAGSMT---YSLVAPKAQRP 1168
Cdd:PHA03307  301 SSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRkrpRPSRAPSSPAA 380

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 672035060 1169 SP--KAPQKVKAAIASIPVGSFESGTTGRTGPTPRQSLDSGVAREPAAPESEL 1219
Cdd:PHA03307  381 SAgrPTRRRARAAVAGRARRRDATGRFPAGRPRPSPLDAGAASGAFYARYPLL 433
HMG-box_NHP10-like cd22016
high mobility group (HMG)-box found in Saccharomyces cerevisiae non-histone protein 10 (NHP10) ...
 186-258 1.23e-05

high mobility group (HMG)-box found in Saccharomyces cerevisiae non-histone protein 10 (NHP10) and similar proteins; NHP10, also called high mobility group protein 2, is probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex.


Pssm-ID: 438832 [Multi-domain]  Cd Length: 79  Bit Score: 45.02  E-value: 1.23e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 672035060  186 EKDGRSPnkrekdhiRRPMNAFMIFSKRHRALVHQR----HPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKE 258
Cdd:cd22016     2 EKDPNAP--------KRPANAFFLFCQEQREKVREEykeeHQEIDHHDLTKALAQAWRNLDAEDKKPYYELYEKDKE 70
HMG-box_PMS1 cd21985
high mobility group (HMG)-box found in PMS1 protein homolog 1 (PMS1) and similar proteins; ...
 200-260 1.71e-05

high mobility group (HMG)-box found in PMS1 protein homolog 1 (PMS1) and similar proteins; PMS1, also called DNA mismatch repair protein PMS1, is probably involved in the repair of mismatches in DNA.


Pssm-ID: 438801 [Multi-domain]  Cd Length: 73  Bit Score: 44.46  E-value: 1.71e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672035060  200 IRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAH 260
Cdd:cd21985     2 IRKPMSASALFEQETRPQFLAENPKASLQDITLKIEERWKNLSEEEKKKYEEKAAKDLERY 62
HMG-box_AtHMGB1-like cd22005
high mobility group (HMG)-box found in Arabidopsis thaliana high mobility group B protein 1 ...
 202-257 1.82e-05

high mobility group (HMG)-box found in Arabidopsis thaliana high mobility group B protein 1 (HMGB1) and similar proteins; This subfamily contains a group of Arabidopsis thaliana HMGB family proteins, including HMGB1, 2, 3, 4, 5, 7, 12 and 14. They bind preferentially to double-stranded DNA. HMGB1 modulates general plant growth and stress tolerance and confers sensitivity to salt and genotoxic (methyl methanesulfonate, MMS) stresses. HMGB2 and HMGB5 confer sensitivity to salt and drought stresses. HMGB7 is required for karyogamy during female gametophyte development, when the two polar nuclei fuse to form the diploid central cell nucleus. Members of this subfamily contain only one HMG-box domain.


Pssm-ID: 438821 [Multi-domain]  Cd Length: 60  Bit Score: 43.84  E-value: 1.82e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 672035060  202 RPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVK 257
Cdd:cd22005     2 RPPTAFFLFLADFRKTYKKKNPDKSVKAVGKAAGEKWKSMSDEEKAPYVEKAEKEK 57
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 1055-1182 2.27e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 49.04  E-value: 2.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1055 SAGQAPL-LAPGQVGVSPVPSPQlppactaPGGPviTAFYPGSPAPTSAPLGPPSQAPPSlvytvATSTTPPAAAILPKG 1133
Cdd:PRK14950  345 SYGQLPLeLAVIEALLVPVPAPQ-------PAKP--TAAAPSPVRPTPAPSTRPKAAAAA-----NIPPKEPVRETATPP 410

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 672035060 1134 PPASATATPAPTSPFPSA--TAGSMTYSLVAPKAQRPSPKaPQKVKAAIAS 1182
Cdd:PRK14950  411 PVPPRPVAPPVPHTPESApkLTRAAIPVDEKPKYTPPAPP-KEEEKALIAD 460
PHA03247 PHA03247
large tegument protein UL36; Provisional
 602-988 2.34e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.55  E-value: 2.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  602 PESVGSLEAPGSSVIAAPPSGGGNILQTLVLPPSKEDREGTRVPSAPAPSLAYGAPAAPlcrPAATMVTNVVRPVSSTPV 681
Cdd:PHA03247 2631 PSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAAR---PTVGSLTSLADPPPPPPT 2707

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  682 PIASKPFPTSGRAEASSNDTVGARTEMGTGSRVPGGSPLGVSLVYSDKKSAAATSPAPHLVAGPLLGTVGKAPATVTNLL 761
Cdd:PHA03247 2708 PEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPA 2787

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  762 VGTPGYGAPASPAVQFIAQgAPGSATPAGSGASAGSGPNGPVPlgilQPGALGKAGGITQVQYILPTLPQQLQVapapAP 841
Cdd:PHA03247 2788 VASLSESRESLPSPWDPAD-PPAAVLAPAAALPPAASPAGPLP----PPTSAQPTAPPPPPGPPPPSLPLGGSV----AP 2858

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  842 APGTKAAAPSGPAPTTSIRFTLPPGTSTNGKVLAATAPTAGIPILQSVPSAPPPKAQSVSPVQATPSGGSAQLLPGKVLV 921
Cdd:PHA03247 2859 GGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPR 2938

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672035060  922 PLAAPSMSVRGGGAGQPLPLVSSPFSVPVQNGAQQPSKIIQLTPVP-VSTPSGLVPPLSPATMPGPTS 988
Cdd:PHA03247 2939 PQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPsREAPASSTPPLTGHSLSRVSS 3006
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
967-1176 3.70e-05

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 48.21  E-value: 3.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  967 PVSTPSGLVPPLSPATMPGPTSQPQKVL-LPSSTRITYVQSAGGHTLPLGTSSACSQTGTVTSYGPASSVALGFTSLGPS 1045
Cdd:COG3469    11 TAGGASATAVTLLGAAATAASVTLTAATaTTVVSTTGSVVVAASGSAGSGTGTTAASSTAATSSTTSTTATATAAAAAAT 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1046 GPAFVQPLLSAGQAPLLAPGQVGVSPVPSPQLPPACTAPGGPVITAFYPGSPAPTSAPLGPPSQAPPSLVYTVATSTTPP 1125
Cdd:COG3469    91 STSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETATGGTTTTSTTT 170

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 672035060 1126 AAAILPKGPPASATATPAPTSPFPSATAGSMtyslvAPKAQRPSPKAPQKV 1176
Cdd:COG3469   171 TTTSASTTPSATTTATATTASGATTPSATTT-----ATTTGPPTPGLPKHV 216
HMG-box_HMGB_rpt1 cd21978
first high mobility group (HMG)-box found in the high mobility group protein B (HMGB) family; ...
 201-258 7.29e-05

first high mobility group (HMG)-box found in the high mobility group protein B (HMGB) family; HMGB proteins are chromatin-associated nuclear proteins that act as architectural factors in nucleoprotein structures, which regulate DNA-dependent processes including transcription. In mammals, four family members are present: HMGB1, HMGB2, HMGB3 and HMGB4. They regulate the expression of a wide range of genes through architectural remodeling of the chromatin structure. HMGB1, also called high mobility group protein 1 (HMG-1), is a prototypical alarmin or damage-associated molecular pattern (DAMP) molecule when released from cells. It plays important roles in the regulation of a wide range of processes, including transcription, replication, DNA repair, and nucleosome formation, in the nucleus. It also plays multiple roles in regulating inflammation and responses to cell and tissue stress. HMGB2, also called high mobility group protein 2 (HMG-2), has been implicated in numerous cellular processes, including proliferation, differentiation, apoptosis, and tumor growth. It acts as a chromatin-associated nonhistone protein involved in transcriptional regulation and nucleic-acid-mediated innate immune responses in mammalian cells. It binds DNA to stabilize nucleosomes and promote transcription. HMGB3, also called high mobility group protein 2a (HMG-2a), or high mobility group protein 4 (HMG-4), is an X-linked member of the HMGB family that functions as a universal sentinel for nucleic acid-mediated innate immune responses. HMGB3 has been implicated in the regulation of cellular proliferation and differentiation, as well as inflammatory responses. HMGB4 is expressed by neuronal cells and affects the expression of genes involved in neural differentiation. It is a factor that regulates chromatin and expression of neuronal differentiation markers. This family also includes high mobility group protein B1 pseudogene 1 (HMGB1P1) and nuclear auto-antigen Sp-100. HMGB1P1, also called putative high mobility group protein B1-like 1 (HMGB1L1), or putative high mobility group protein 1-like 1 (HMG-1L1), is an HMG-box containing protein that binds preferentially single-stranded DNA and unwinds double-stranded DNA. Sp-100, also called nuclear dot-associated Sp100 protein, or speckled 100 kDa, is a tumor suppressor that is a major constituent of promyelocytic leukemia (PML) bodies, a subnuclear organelle involved in many physiological processes including cell growth, differentiation and apoptosis. Through the regulation of ETS1, Sp-100 may play a role in angiogenesis, controlling endothelial cell motility and invasion. It may also play roles in the regulation of telomere lengthening, TP53-mediated transcription, FAS-mediated apoptosis, etc. In addition, the family includes Drosophila melanogaster high mobility group protein DSP1 (dDSP1) and similar proteins. dDSP1, also called protein dorsal switch 1, binds preferentially to single-stranded DNA and unwinds double-stranded DNA. It converts Dorsal and nuclear factor (NF)-kappa B from transcriptional activators to repressors. Members of the HMGB family contain two HMG-box domains. This model corresponds to the first one.


Pssm-ID: 438794 [Multi-domain]  Cd Length: 69  Bit Score: 42.29  E-value: 7.29e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  201 RRPMNAFMIFSKRHRALVHQRHPNQ--DNRTVSKILGEWWYALGPKEKQKYHDLAFQVKE 258
Cdd:cd21978     3 RGKMSSYAFFVQTCREEHKKKHPNEsvNFSEFSKKCSERWKTMSAKEKKKFEDMAKKDKA 62
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
1008-1209 1.23e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 46.79  E-value: 1.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1008 GGHTLPLGTSSACSQTGTVTSYGPASSVALGFTSLGPSGPAFVQPLLSAGQAPLLAPGQVGVSPVPSPQLPPACTAPGGP 1087
Cdd:PRK12323  369 GGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAP 448

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1088 VITAFYPGSPAPTSAPLGPPSQAPPSLVYTVATSTTPPAA-AILPKGPPASATATPAPTSPFP----SATAGSMTYSLVA 1162
Cdd:PRK12323  449 APAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAApAPADDDPPPWEELPPEFASPAPaqpdAAPAGWVAESIPD 528

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 672035060 1163 PKAQRPSPKAPQKVKAAIASiPVGSFESGTTGRTGPTPRQSLDSGVA 1209
Cdd:PRK12323  529 PATADPDDAFETLAPAPAAA-PAPRAAAATEPVVAPRPPRASASGLP 574
PHA03378 PHA03378
EBNA-3B; Provisional
 1044-1210 1.87e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 46.21  E-value: 1.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1044 PSGPAFVQPLLSA---GQAPLLAPGqvgvsPVPSPQLPPACTAPGGPVITAFYPGSPAPTSA--PLGPPSQAPPSlvYTV 1118
Cdd:PHA03378  678 PTGANTMLPIQWApgtMQPPPRAPT-----PMRPPAAPPGRAQRPAAATGRARPPAAAPGRArpPAAAPGRARPP--AAA 750

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1119 ATSTTPPAAAILPKGPPASATATPAPTSPfPSATAGSMTYSLVAPKAQRPSPKAPQKVKAAIASIPvgsfesGTTGRTGP 1198
Cdd:PHA03378  751 PGRARPPAAAPGRARPPAAAPGAPTPQPP-PQAPPAPQQRPRGAPTPQPPPQAGPTSMQLMPRAAP------GQQGPTKQ 823

                         170
                  ....*....|..
gi 672035060 1199 TPRQSLDSGVAR 1210
Cdd:PHA03378  824 ILRQLLTGGVKR 835
HMG-box_BHMG1 cd21977
high mobility group (HMG)-box found in basic helix-loop-helix and HMG box domain-containing ...
 204-260 1.98e-04

high mobility group (HMG)-box found in basic helix-loop-helix and HMG box domain-containing protein 1 (BHMG1) and similar proteins; BHMG1 is an uncharacterized HMG-box containing protein that contains a degenerate basic motif not likely to bind DNA.


Pssm-ID: 438793 [Multi-domain]  Cd Length: 66  Bit Score: 41.15  E-value: 1.98e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 672035060  204 MNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAH 260
Cdd:cd21977     5 VNGFIMFCRLNRKNYIDKHPGLASTELTKELGQLWRELSAEEKKPYCVRARELSQLH 61
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
929-1155 2.08e-04

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 45.90  E-value: 2.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  929 SVRGGGAGQPLPLVSSPFSVPVQNGAQQPSKIIQLTPVPVSTPSGLVPPLSPATMP-GPTSQPQKVLLPSSTRITYVQSA 1007
Cdd:COG3469     3 SVSTAASPTAGGASATAVTLLGAAATAASVTLTAATATTVVSTTGSVVVAASGSAGsGTGTTAASSTAATSSTTSTTATA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1008 GGHTLPLGTSSACSQTGTVTSYGPASSVALGFTSLGPSGPAFVQPLLSAGQAPLLAPGQVGVSpvpspqlppACTAPGGP 1087
Cdd:COG3469    83 TAAAAAATSTSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSAG---------STTTTTTV 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672035060 1088 VITAFYPGSPAPTSAPLGPPSQAPPslvYTVATSTTPPAAAilpkGPPASATATPAPTSPFPSATAGS 1155
Cdd:COG3469   154 SGTETATGGTTTTSTTTTTTSASTT---PSATTTATATTAS----GATTPSATTTATTTGPPTPGLPK 214
PHA03247 PHA03247
large tegument protein UL36; Provisional
 950-1336 3.22e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 3.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  950 VQNGAQQPSKIIQLTPVPVSTPSGLVPPLSPATMPGPTSQPQKVLLPSSTRITYVQSAGGHTLPLGTSSAcsqtgtvtSY 1029
Cdd:PHA03247 2491 AAGAAPDPGGGGPPDPDAPPAPSRLAPAILPDEPVGEPVHPRMLTWIRGLEELASDDAGDPPPPLPPAAP--------PA 2562

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1030 GPASSVALGFTSLGPSGPAF--------VQPLLSAGQAPLLAPGQVGVSPVPSPqLPPACTAPGGPVitafYPGSPAPTS 1101
Cdd:PHA03247 2563 APDRSVPPPRPAPRPSEPAVtsrarrpdAPPQSARPRAPVDDRGDPRGPAPPSP-LPPDTHAPDPPP----PSPSPAANE 2637

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1102 APLGPPSQAPPSLVYTVATS---TTPPAAAILPKGPPASATATPAPTSPFPSATAGSMTySLVAPKAQRPSPKAPQKvkA 1178
Cdd:PHA03247 2638 PDPHPPPTVPPPERPRDDPApgrVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLT-SLADPPPPPPTPEPAPH--A 2714

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1179 AIASIPVGSFESGTTGRTGPTPRQSLDSGVAREPAAPESELEGQPTPPAPPPPTETWPPTARSSPPPPLPAEERPGTKGP 1258
Cdd:PHA03247 2715 LVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSES 2794

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1259 ETASKFPSSSSDWRVPGLGLESR---------GEPPTPPSPAPAPATGPSGSSSGSSEGSSGRAAGDTPERKEVTSSGKK 1329
Cdd:PHA03247 2795 RESLPSPWDPADPPAAVLAPAAAlppaaspagPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAK 2874


                  ....*..
gi 672035060 1330 MKVRPPP 1336
Cdd:PHA03247 2875 PAAPARP 2881
HMG-box_SMARCE1 cd21983
high mobility group (HMG)-box found in SWI/SNF-related matrix-associated actin-dependent ...
 202-251 3.30e-04

high mobility group (HMG)-box found in SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (SMARCE1) and similar proteins; SMARCE1, also called BRG1-associated factor 57 (BAF57), is a ubiquitously expressed protein involved in transcriptional activation and repression of select genes by chromatin remodeling. It is a component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. SMARCE1 has a single HMG domain that displays non-specific DNA-binding characteristics. It also contains a kinesin-like coiled-coil (KLCC) domain.


Pssm-ID: 438799 [Multi-domain]  Cd Length: 73  Bit Score: 40.74  E-value: 3.30e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 672035060  202 RPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHD 251
Cdd:cd21983     7 KPLMPYMRYSRKVWDQVKASNPDLKLWEIGKIIGQMWRELSDEEKQEYIE 56
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 1047-1184 3.40e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 45.09  E-value: 3.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1047 PAFVQPLLSAGQAPLLAPGQVGvSPVPSPQLPPActAPGGPVITAfypgsPAPTSAPLGPPSQAPPslvytvATSTTPPA 1126
Cdd:PRK14951  366 PAAAAEAAAPAEKKTPARPEAA-APAAAPVAQAA--AAPAPAAAP-----AAAASAPAAPPAAAPP------APVAAPAA 431

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 672035060 1127 AAILPKGPPASATATPAPTSPFPSATAGSMTYSLVAP-KAQRPSPKAPQKVKAAIASIP 1184
Cdd:PRK14951  432 AAPAAAPAAAPAAVALAPAPPAQAAPETVAIPVRVAPePAVASAAPAPAAAPAAARLTP 490
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1036-1418 3.58e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 45.55  E-value: 3.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1036 ALGFTSLGPSGPAFVQPLLSAGQAPLLAP-----GQVGVSPVPSPQLPPACTAPGGPVITAFYPGSPAPTSAPLGPPSQA 1110
Cdd:PHA03307    4 APDLYDLIEAAAEGGEFFPRPPATPGDAAddllsGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1111 PPSLVYTVATSTTPPAAAILPKGPPASATATPAPTSPFPSATAGSMTYSLVAPKAQR-PSPKAPQKVKAAIASIPVGSFE 1189
Cdd:PHA03307   84 SRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPvGSPGPPPAASPPAAGASPAAVA 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1190 SGTTGRTGPTPRQSLDSGVAREPAAPESELEGQPTPPAPPPPTETWPPTARSSPPPPLPAEERPGTKGPETASKFPSSSS 1269
Cdd:PHA03307  164 SDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSE 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1270 DWRVPGLGLESRGEPPTPPSPAPAPATGPSGSSSGSSEGSSGRAAGDTPERKEVTSSGKKmkvRPPPLKKTFDSVDNRVL 1349
Cdd:PHA03307  244 SSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSP---GSGPAPSSPRASSSSSS 320

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672035060 1350 S-EVDFEERFAELPEFRPEEVLPSPTLQSLATSPR---AILGSYRKKRKNSTDLDSAPedPTSPKRKMRRRSS 1418
Cdd:PHA03307  321 SrESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRpppPADPSSPRKRPRPSRAPSSP--AASAGRPTRRRAR 391
HMG-box_PB1 cd21984
high mobility group (HMG)-box found in protein polybromo-1 (PB1) and similar proteins; PB1, ...
 201-258 3.85e-04

high mobility group (HMG)-box found in protein polybromo-1 (PB1) and similar proteins; PB1, also called BRG1-associated factor 180 (BAF180), or polybromo-1D, is a subunit of the PBAF (polybromo/Brg1-associated factor) chromatin-remodeling complex required for kinetochore localization during mitosis and the transcription of estrogen-responsive genes. It is involved in transcriptional activation and repression of select genes by chromatin remodeling. It acts as a negative regulator of cell proliferation.


Pssm-ID: 438800 [Multi-domain]  Cd Length: 60  Bit Score: 39.92  E-value: 3.85e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 672035060  201 RRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKE 258
Cdd:cd21984     1 KRNPSGYILFSSEVRKSIKAENPDYSFGEISRLVGTEWRNLPAEKKAEYEERAQKQAE 58
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
969-1153 4.04e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 45.23  E-value: 4.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  969 STPSGLVPPLSPATMPGPtsQPQKVLLPSSTRITYVQSAGGHTLPLGTSSACSQTGTVTSYGPASSVALGFTSLGPSGPA 1048
Cdd:PRK07003  366 GAPGGGVPARVAGAVPAP--GARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAA 443

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1049 fvqpllsAGQAPLLAPGQVGVSPVPSPQLPPACTAPGGPVITAFYPGSPAPTSAPLGPPSQAPPSLVYTVATSTTPPAAA 1128
Cdd:PRK07003  444 -------DGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAA 516

                         170       180
                  ....*....|....*....|....*
gi 672035060 1129 ILPKGPPASATATPAPTSPFPSATA 1153
Cdd:PRK07003  517 SREDAPAAAAPPAPEARPPTPAAAA 541
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
867-1078 5.28e-04

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 44.74  E-value: 5.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  867 TSTNGKVLAATAPTAGIPILQSVPSAPPPKAQSVSPVQATPSGGSAQLLPGKVLVPLAAPSMSVRGGGAGQPLPLVSSPF 946
Cdd:COG3469     2 SSVSTAASPTAGGASATAVTLLGAAATAASVTLTAATATTVVSTTGSVVVAASGSAGSGTGTTAASSTAATSSTTSTTAT 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  947 SVPVQNGAQQPSKIIQLTPVPVSTPSGLVPPLSPATMPGPTSQPQKVLLPSSTRITYVQSAGGHTLPLGTSSACSQTGTV 1026
Cdd:COG3469    82 ATAAAAAATSTSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETATG 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 672035060 1027 TSYGPASSVALGFTSLGPSGPAFVQPLLSAGQAPLLAPGQVGVSPVPSPQLP 1078
Cdd:COG3469   162 GTTTTSTTTTTTSASTTPSATTTATATTASGATTPSATTTATTTGPPTPGLP 213
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 1045-1184 5.46e-04

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 43.99  E-value: 5.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1045 SGPAFVQPLLSAGQAPLLAPGQVGVSPVPSPQLPPACTAPGGPVITAFYPGSPAPTSA--PLGPPSQAPPSLVYTVATST 1122
Cdd:NF040712  188 IDPDFGRPLRPLATVPRLAREPADARPEEVEPAPAAEGAPATDSDPAEAGTPDDLASArrRRAGVEQPEDEPVGPGAAPA 267

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 672035060 1123 TPPAAAILPKGPP-----ASATATPAPTSPFPSATAGSMTYSLVAPKAQRPSPKAPQKVKAAIASIP 1184
Cdd:NF040712  268 AEPDEATRDAGEPpapgaAETPEAAEPPAPAPAAPAAPAAPEAEEPARPEPPPAPKPKRRRRRASVP 334
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 1015-1203 7.13e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 44.52  E-value: 7.13e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  1015 GTSSACSQTGTVTSYGPASSV-ALGFTSLGPSGPAFVQPLLSAGQAP--LLAPGQVG--VSPVPSPQLPPACTAPGGPvi 1089
Cdd:pfam05109  409 ATNATTTTHKVIFSKAPESTTtSPTLNTTGFAAPNTTTGLPSSTHVPtnLTAPASTGptVSTADVTSPTPAGTTSGAS-- 486

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  1090 tafyPGSPAPTSAPLGPPSQAPPSLVYTVATSTTPPAAAilpkgPPASATATPAPTSPFPSATAGSMTYSLVAPKAQRPS 1169
Cdd:pfam05109  487 ----PVTPSPSPRDNGTESKAPDMTSPTSAVTTPTPNAT-----SPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATS 557

                          170       180       190
                   ....*....|....*....|....*....|....
gi 672035060  1170 PKAPQKVKAAIASIPVGSFESGTTGRTGPTPRQS 1203
Cdd:pfam05109  558 PTPAVTTPTPNATIPTLGKTSPTSAVTTPTPNAT 591
HMG-box_AtSSRP1 cd22013
high mobility group (HMG)-box found in Arabidopsis thaliana FACT complex subunit SSRP1 and ...
 194-268 7.60e-04

high mobility group (HMG)-box found in Arabidopsis thaliana FACT complex subunit SSRP1 and similar proteins; SSRP1, also called facilitates chromatin transcription complex subunit SSRP1, high mobility group B protein 8, nucleosome/chromatin assembly factor group D 08 (or D 8), protein NUCLEAR FUSION DEFECTIVE 8, or recombination signal sequence recognition protein 1, is a component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication, and DNA repair. SSRP1 may bind specifically to double-stranded DNA. It is required for karyogamy during female gametophyte development, when the two polar nuclei fuse to form the diploid central cell nucleus. SSRP1 contains only one HMG-box domain.


Pssm-ID: 438829 [Multi-domain]  Cd Length: 80  Bit Score: 39.84  E-value: 7.60e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 672035060  194 KREKD--HIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWK 268
Cdd:cd22013     1 KKKKDpnAPKRALSGFMFFSLMERENLKKEKPGISFGEVGKVLGEKWKNMSADDKAPYEAKAQVDKERYKKEMSGYK 77
HMG-box_HMG20B cd22018
high mobility group (HMG)-box found in high mobility group protein 20B (HMG20B) and similar ...
 201-262 8.84e-04

high mobility group (HMG)-box found in high mobility group protein 20B (HMG20B) and similar proteins; HMG20B, also called SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related, SMARCE1-related protein (SMARCE1R), BRCA2-associated factor 35 (BRAF35), HMG box-containing protein 20B, HMG domain-containing protein 2 (HMGXB2), HMG domain-containing protein HMGX2, Sox-like transcriptional factor, or structural DNA-binding protein BRAF35, is a DNA binding factor that acts as a repressor of erythroid differentiation. It is required for correct progression through the G2 phase of the cell cycle and entry into mitosis. It is also required for RCOR1/CoREST mediated repression of neuronal specific gene promoters. HMG20B is a core subunit of the Lys-specific demethylase 1/REST co-repressor 1 (LSD1-CoREST) histone demethylase complex.


Pssm-ID: 438834 [Multi-domain]  Cd Length: 85  Bit Score: 39.96  E-value: 8.84e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 672035060  201 RRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFK 262
Cdd:cd22018     3 KAPVTGYVRFLNERREQIRTQHPDLPFPEITKMLGAEWSKLQPHEKQRYLDEAERDKQQYMK 64
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
1055-1188 9.12e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 44.00  E-value: 9.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1055 SAGQAPLLAPGQVGVSPVPSPQLPPACTAPGGPVITAFYPGSPAPTSAPlgPPSQAPPSL-VYTVATSTTPPAAAILPKG 1133
Cdd:PRK14971  370 SGGRGPKQHIKPVFTQPAAAPQPSAAAAASPSPSQSSAAAQPSAPQSAT--QPAGTPPTVsVDPPAAVPVNPPSTAPQAV 447

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 672035060 1134 PPASAtatpAPTSPFPSATAGSMTYSLVAPKaQRPSPKAPQKVKAAIASIPVGSF 1188
Cdd:PRK14971  448 RPAQF----KEEKKIPVSKVSSLGPSTLRPI-QEKAEQATGNIKEAPTGTQKEIF 497
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 1047-1178 1.00e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 43.70  E-value: 1.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1047 PAFVQPLLSAGQAPLLAPGQVGVSPVPSPQLPPACTAPGGPvitafyPGSPAPTSAPLGPPSQAPPSLVytVATSTTPPA 1126
Cdd:PRK07994  361 PAAPLPEPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPP------PPASAPQQAPAVPLPETTSQLL--AARQQLQRA 432

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 672035060 1127 AAILPkgPPASATATPAPTSPFPSATAgsmtysLVAPKAQRPSPKAPQKVKA 1178
Cdd:PRK07994  433 QGATK--AKKSEPAAASRARPVNSALE------RLASVRPAPSALEKAPAKK 476
HMG-box_NSD2 cd21991
high mobility group (HMG)-box found in nuclear SET domain-containing protein 2 (NSD2) and ...
 200-249 1.05e-03

high mobility group (HMG)-box found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins; NSD2, also called multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1), acts as a histone-lysine N-methyltransferase with histone H3 'Lys-36' (H3K36me) methyltransferase activity. NSD2 has been shown to mediate di- and trimethylation of H3K36 and dimethylation of H4K20 in different systems and has been characterized as a transcriptional repressor interacting with histone deacetylase HDAC1 and histone demethylase LSD1. NSD2 mediates constitutive NF-kappaB signaling for cancer cell proliferation, survival and tumor growth. It is highly overexpressed in several types of human cancers, including small-cell lung cancers, neuroblastoma, carcinomas of stomach and colon, and bladder cancers, and its overexpression tends to be associated with tumor aggressiveness.


Pssm-ID: 438807 [Multi-domain]  Cd Length: 62  Bit Score: 38.83  E-value: 1.05e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 672035060  200 IRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKY 249
Cdd:cd21991     2 KKVKKGQFEVFCQKHREEVAQEHPDLSEEEIEEYLKKQWNNMSEKQRARY 51
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 1090-1183 1.45e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 43.34  E-value: 1.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1090 TAFYPGSPAPTSAPLGPPSQAPPSLVYTVATSTTPPAAAILPKGPPASATATPAPTSPFPSATAGSMTYSLVAPKAQRPS 1169
Cdd:PRK12270   34 ADYGPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAAAAAPAAAAV 113

                          90
                  ....*....|....
gi 672035060 1170 PKAPQKVKAAIASI 1183
Cdd:PRK12270  114 EDEVTPLRGAAAAV 127
HMG-box_UBF1_rpt1-like cd21998
first high mobility group (HMG)-box found in upstream-binding factor 1 (UBF1) and similar ...
 198-266 1.50e-03

first high mobility group (HMG)-box found in upstream-binding factor 1 (UBF1) and similar proteins; UBF1, also called UBTF, nucleolar transcription factor 1, or auto-antigen NOR-90, is a nucleolar transcription factor that recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element. UBF1 contains six HMG-box domains. This model corresponds to the first one. This model also includes the first HMG-box domain of upstream-binding factor 1-like protein 1 (UBTFL1), which contains two HMG-box domains.


Pssm-ID: 438814 [Multi-domain]  Cd Length: 77  Bit Score: 38.84  E-value: 1.50e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672035060  198 DHIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHD------LAFQVKEAHFKA-HPD 266
Cdd:cd21998     2 DFPKKPLTPYFRFFMEKRAKYAKKHPEMSNLELTKILSKKYKELPEKKKQKYIQdyekekEEYEQKMARFREeHPD 77
HMG-box_CMB1-like cd22014
high mobility group (HMG)-box found in Schizosaccharomyces pombe mismatch-binding protein cmb1 ...
 202-263 1.54e-03

high mobility group (HMG)-box found in Schizosaccharomyces pombe mismatch-binding protein cmb1 and similar proteins; Cmb1 binds to cytosines in base mismatches and opposite chemically altered guanines. It contains only one HMG-box domain.


Pssm-ID: 438830 [Multi-domain]  Cd Length: 62  Bit Score: 38.50  E-value: 1.54e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 672035060  202 RPMNAFMIFSKRHRALVHQRHPNQDNrtvSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKA 263
Cdd:cd22014     3 RPPSPFLLFMEEFRRNEDNGKNLVEL---SRIAAEAWKNMSEDEKQPYIDRAKELLEEYKKQ 61
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
1044-1150 1.59e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 43.23  E-value: 1.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1044 PSGPAFVQP----LLSAGQAPLLAPGQVGVSPvPSPQLPPACTAPGGPVITAFYPGSPAPTSAPLGPPSQAPPSLVY--- 1116
Cdd:PRK14971  378 HIKPVFTQPaaapQPSAAAAASPSPSQSSAAA-QPSAPQSATQPAGTPPTVSVDPPAAVPVNPPSTAPQAVRPAQFKeek 456

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 672035060 1117 TVATSTTPPAAAIL--PKGPPASATATPAPTSPFPS 1150
Cdd:PRK14971  457 KIPVSKVSSLGPSTlrPIQEKAEQATGNIKEAPTGT 492
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
1091-1261 1.64e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.94  E-value: 1.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1091 AFYP----GSPAPTSAPLGPPSQAPPSLVYTVATSTTPPAAAILPKGPPASATATPAPT------SPFPSATAGSMTYSL 1160
Cdd:PRK12323  362 AFRPgqsgGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAaaparrSPAPEALAAARQASA 441

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1161 VAPKAQRPSPKAPQKVKAAIASIPVGSfesgttgrTGPTPRQSLDSGVAREPAAPESELEGQPTPPAPPPPTETWPPTAR 1240
Cdd:PRK12323  442 RGPGGAPAPAPAPAAAPAAAARPAAAG--------PRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQ 513

                         170       180
                  ....*....|....*....|....
gi 672035060 1241 SSPPPPLPAEE---RPGTKGPETA 1261
Cdd:PRK12323  514 PDAAPAGWVAEsipDPATADPDDA 537
HMG-box_HMGXB4 cd21982
high mobility group (HMG)-box found in HMG domain-containing protein 4 (HMGXB4) and similar ...
 201-247 1.73e-03

high mobility group (HMG)-box found in HMG domain-containing protein 4 (HMGXB4) and similar proteins; HMGXB4, also called HMG box-containing protein 4, high mobility group protein 2-like 1 (HMG2L1), or protein HMGBCG, is a non-histone chromosomal protein that negatively regulates Wnt/beta-catenin signaling during development. It plays a role in the hematopoietic system.


Pssm-ID: 438798 [Multi-domain]  Cd Length: 61  Bit Score: 38.41  E-value: 1.73e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 672035060  201 RRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQ 247
Cdd:cd21982     2 KKNMSAYQVFCKEYRVSIVAEHPGIDFGELSKKLAEVWKQLPEKDKL 48
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 823-1149 2.33e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.83  E-value: 2.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060   823 QYILPTLPQQLQVAPAPAPAPGTKAAAPSG---PAPTTSIRFTLPPGTSTNGKVLAATAPTAG-IPILQSVPSAPPPKAQ 898
Cdd:pfam03154  164 QQILQTQPPVLQAQSGAASPPSPPPPGTTQaatAGPTPSAPSVPPQGSPATSQPPNQTQSTAApHTLIQQTPTLHPQRLP 243

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060   899 SV-SPVQ-----ATPSGGSAQLLPGKVL-VPLAAPSMSVRGGGAGQPLPLVSSPFSVPVQNGAQQ-----------PSKI 960
Cdd:pfam03154  244 SPhPPLQpmtqpPPPSQVSPQPLPQPSLhGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQvppgpspaapgQSQQ 323

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060   961 IQLTPVPVSTPSGLVPPLSPATMPGPTSQPQkVLLPSSTRITYVQSAGGHTLPLGTSSAcsQTGTVTSYGPASSVALGFT 1040
Cdd:pfam03154  324 RIHTPPSQSQLQSQQPPREQPLPPAPLSMPH-IKPPPTTPIPQLPNPQSHKHPPHLSGP--SPFQMNSNLPPPPALKPLS 400

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  1041 SLGPSGPAFVQP----LLSAGQAPLLAPGQVGV------SPVPSPQLPPACTAPGGPVIT-----AFYPGSPAPTSAPLG 1105
Cdd:pfam03154  401 SLSTHHPPSAHPpplqLMPQSQQLPPPPAQPPVltqsqsLPPPAASHPPTSGLHQVPSQSpfpqhPFVPGGPPPITPPSG 480

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 672035060  1106 P-------------PSQAPPSLVYTVATSTTPPAAAILPKGPPASATATPAPTSPFP 1149
Cdd:pfam03154  481 PptstssampgiqpPSSASVSSSGPVPAAVSCPLPPVQIKEEALDEAEEPESPPPPP 537
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 1024-1152 5.19e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 41.24  E-value: 5.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1024 GTVTSYGPASSVALGFTSLGPSGPAfVQPLLSAGQAPLLAPGQVGVSPVPSP-QLPPACTAPGGPVI-TAFYPGSPAPTS 1101
Cdd:PRK14951  368 AAAEAAAPAEKKTPARPEAAAPAAA-PVAQAAAAPAPAAAPAAAASAPAAPPaAAPPAPVAAPAAAApAAAPAAAPAAVA 446

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 672035060 1102 APLGPPSQAPPSLVY---TVATSTTPPAAAILPKGPPASATATPAPTSPFPSAT 1152
Cdd:PRK14951  447 LAPAPPAQAAPETVAipvRVAPEPAVASAAPAPAAAPAAARLTPTEEGDVWHAT 500
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 1068-1165 5.30e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 41.80  E-value: 5.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1068 GVSPVPSPQLPPACTAPGGPVITAFYPGSPAPTSAPLGPPSQAPPslvytVATSTTPPAAAILPKGPPASATATPAPTSP 1147
Cdd:PRK12270   37 GPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPA-----APPKPAAAAAAAAAPAAPPAAAAAAAPAAA 111

                          90       100
                  ....*....|....*....|....*....
gi 672035060 1148 FPS-----------ATAGSMTYSLVAPKA 1165
Cdd:PRK12270  112 AVEdevtplrgaaaAVAKNMDASLEVPTA 140
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 45-151 5.55e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.51  E-value: 5.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060   45 APSQPDPSVQPSEAQQPASHPVASNQ-SKEPAESAAVAHEQPPGGTGGADPGRPPGATCPESPGPGPPLTLGGVDPGKSL 123
Cdd:PRK07764  683 PAPAPAAPAAPAGAAPAQPAPAPAATpPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPP 762

                          90       100
                  ....*....|....*....|....*...
gi 672035060  124 PPTTEEEAPGPPGEPRLDSETESDHDDA 151
Cdd:PRK07764  763 APAPAAAPAAAPPPSPPSEEEEMAEDDA 790
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
1043-1217 5.59e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 41.37  E-value: 5.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1043 GPSGPAFVQPLLSAGQAPllAPGQVGVSPVPSPQLPPACTAPGGPVITAF-YPGSPAPTSAPLGPPSQAPPSLVYTVATS 1121
Cdd:PRK07003  364 GGGAPGGGVPARVAGAVP--APGARAAAAVGASAVPAVTAVTGAAGAALApKAAAAAAATRAEAPPAAPAPPATADRGDD 441

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1122 TTP-PAAAILPKGPPASATATPAPTSPFP-SATAGSMTYSLVAPKAQRPSPKAPQKVKAAIASIPVGSFESgttgrtgPT 1199
Cdd:PRK07003  442 AADgDAPVPAKANARASADSRCDERDAQPpADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARA-------PA 514

                         170
                  ....*....|....*...
gi 672035060 1200 PRQSLDSGVAREPAAPES 1217
Cdd:PRK07003  515 AASREDAPAAAAPPAPEA 532
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
646-788 5.93e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 41.37  E-value: 5.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  646 SAPAPSLAYGAPAAPLCRPAATMVTNVVRPVSSTPVPIASKPFPTSGRAEASSNDTVGARTEMGTGSRVPGGSPLGVSLV 725
Cdd:PRK07003  383 PGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGDAPVPAKANARASADSR 462

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672035060  726 YSDKKSAAATSPAPHLVAGPllgtvgKAPATVTNllvgtpgygAPASPAVQFIAQGAPGSATP 788
Cdd:PRK07003  463 CDERDAQPPADSGSASAPAS------DAPPDAAF---------EPAPRAAAPSAATPAAVPDA 510
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 934-1269 6.36e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 41.31  E-value: 6.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  934 GAGQPLPLVSSPFSVPVQNGAQQPSKIIQLTPVPVSTPSGLVPPLSPATMPGPTSQPQKVLLPSSTRityVQSAGGHTLP 1013
Cdd:PHA03307   38 GSQGQLVSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREG---SPTPPGPSSP 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1014 LGTSSacsqtgTVTSYGPASSVALGFTSLGPSGPAFVQPLLSAGQAPLLAPGQVGVSPVPSPQLPPACTAPGGPVITAFY 1093
Cdd:PHA03307  115 DPPPP------TPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSS 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1094 PGSPAPTSAPLGPPSQAPPSLVYTVATSTTPPAAAiLPKGPPASATATPAPTSPFPSATAGSMTYSLvAPKAQRPSPKAP 1173
Cdd:PHA03307  189 PPAEPPPSTPPAAASPRPPRRSSPISASASSPAPA-PGRSAADDAGASSSDSSSSESSGCGWGPENE-CPLPRPAPITLP 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1174 QKVKAAIASIPVG------SFESGTTGRTGPTPRQSLDSGVAREPAAPESELEGQPTPPAPPPPTETWPPTARSSPPPPL 1247
Cdd:PHA03307  267 TRIWEASGWNGPSsrpgpaSSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPS 346

                         330       340
                  ....*....|....*....|..
gi 672035060 1248 PaeERPGTKGPETASKFPSSSS 1269
Cdd:PHA03307  347 P--SRSPSPSRPPPPADPSSPR 366
HMG-box_TOX-like cd21995
high mobility group (HMG)-box found in the TOX high mobility group box family; The TOX family ...
 201-263 6.38e-03

high mobility group (HMG)-box found in the TOX high mobility group box family; The TOX family includes four members: TOX, TOX2, TOX3 and TOX4. TOX, also called thymus high mobility group box protein TOX, is a transcriptional regulator with a major role in neural stem cell commitment and corticogenesis as well as in lymphoid cell development and lymphoid tissue organogenesis. It binds to GC-rich DNA sequences in the proximity of transcription start sites and may alter chromatin structure, modifying access of transcription factors to DNA. TOX2, also called granulosa cell HMG box protein 1 (GCX-1), is a putative transcriptional activator involved in the hypothalamic-pituitary-gonadal system. TOX3, also called CAG trinucleotide repeat-containing gene F9 protein (CAGF9), or trinucleotide repeat-containing gene 9 protein (TNRC9), is a transcriptional coactivator of the p300/CBP-mediated transcription complex. It activates transactivation through cAMP response element (CRE) sites. It protects against cell death by inducing anti-apoptotic and repressing pro-apoptotic transcripts. TOX4, also called epidermal Langerhans cell protein LCP1, is a component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. All family members contain one HMG-box domain.


Pssm-ID: 438811 [Multi-domain]  Cd Length: 70  Bit Score: 37.07  E-value: 6.38e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672035060  201 RRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKA 263
Cdd:cd21995     1 QKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIVASMWDSLDEEQKQVYKKKTEAAKKEYLKA 63
rad23 TIGR00601
UV excision repair protein Rad23; All proteins in this family for which functions are known ...
 1096-1167 7.50e-03

UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273167 [Multi-domain]  Cd Length: 378  Bit Score: 40.65  E-value: 7.50e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672035060  1096 SPAPTSAPLGPPSQAPPSLVYTVATSTTPPAAAILPKGPPASATATPAPTSPFPSATA-GSMTYSLVAPKAQR 1167
Cdd:TIGR00601   84 VAPPAATPTSAPTPTPSPPASPASGMSAAPASAVEEKSPSEESATATAPESPSTSVPSsGSDAASTLVVGSER 156
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 1091-1219 8.08e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 40.85  E-value: 8.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1091 AFYPGSPAPTSAPLGPPSQAPPSLVYTVATSTTPPAAAILPKGPPASAT-ATPAPTSPFPSATAGSMTYSLVAPKAQR-P 1168
Cdd:PRK14951  363 AFKPAAAAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAAsAPAAPPAAAPPAPVAAPAAAAPAAAPAAaP 442

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 672035060 1169 SPKAPQKVKAAIASIPVGSFESGTTGRTGPTPRQSLDSGVAREPAAPESEL 1219
Cdd:PRK14951  443 AAVALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAARLTPTEE 493
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 851-1146 8.23e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 41.06  E-value: 8.23e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060   851 SGPAPTtsirftlPPGTSTNGKVLAATAPTAGIpilqsvpSAPPPKAQSVSPVQATPSGGSAQLLPGKVlVPLAApsMSV 930
Cdd:pfam05109  488 VTPSPS-------PRDNGTESKAPDMTSPTSAV-------TTPTPNATSPTPAVTTPTPNATSPTLGKT-SPTSA--VTT 550

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060   931 RGGGAGQPLPLVSSPF---SVPVQNGAQQPSKIIQLTPVPVSTPSGLVPPLSPA---TMPGPTSQPqkVLLPSSTRITYV 1004
Cdd:pfam05109  551 PTPNATSPTPAVTTPTpnaTIPTLGKTSPTSAVTTPTPNATSPTVGETSPQANTtnhTLGGTSSTP--VVTSPPKNATSA 628

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  1005 QSAGGHTLPLGTSSACSQTGTVTSYGPASSVALGFTSLgpsgpafvQPLLSAGQaPLLAPGQVGVSPVPSPQLPPACTAP 1084
Cdd:pfam05109  629 VTTGQHNITSSSTSSMSLRPSSISETLSPSTSDNSTSH--------MPLLTSAH-PTGGENITQVTPASTSTHHVSTSSP 699

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 672035060  1085 ggpvitAFYPGSPAPTSAPLGPPSQAPPSLVYTvaTSTTPPAAAILPKGPPASATATPAPTS 1146
Cdd:pfam05109  700 ------APRPGTTSQASGPGNSSTSTKPGEVNV--TKGTPPKNATSPQAPSGQKTAVPTVTS 753
FAP pfam07174
Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment ...
 1055-1162 9.60e-03

Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment proteins (FAP). Family members are rich in alanine and proline, are approximately 300 long, and seem to be restricted to mycobacteria. These proteins contain a fibronectin-binding motif that allows mycobacteria to bind to fibronectin in the extracellular matrix.


Pssm-ID: 429334  Cd Length: 301  Bit Score: 39.91  E-value: 9.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060  1055 SAGQAPLLAPGQVGVSPVPSPQLPPACTAPGGPVITAFYPGSPAPTSAPLGPPSQAPPSlvyTVATSTTPPAAAILPKGP 1134
Cdd:pfam07174   25 GASAVAVALPAVAHADPEPAPPPPSTATAPPAPPPPPPAPAAPAPPPPPAAPNAPNAPP---PPADPNAPPPPPADPNAP 101

                           90       100
                   ....*....|....*....|....*...
gi 672035060  1135 PASATATPAPTSPFPSATAGSMTYSLVA 1162
Cdd:pfam07174  102 PPPAVDPNAPEPGRIDNAVGGFSYVVPA 129
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 1009-1195 9.90e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 40.84  E-value: 9.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1009 GHTLPLGTSSACSQTGTVTSYGPASSVALGFTSLGPSGPAFVQPLLSAGQA-------PLLAPGQVGVSPVPSPQLPPAC 1081
Cdd:PRK10263  313 GAPITEPVAVAAAATTATQSWAAPVEPVTQTPPVASVDVPPAQPTVAWQPVpgpqtgePVIAPAPEGYPQQSQYAQPAVQ 392

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672035060 1082 TA-----PGGPVITAFYPGSPAPTSAPLGPPSQAPPSLVYTVATSTTPPAAAILPKGPPASATATPAPTSPFPSAtagsm 1156
Cdd:PRK10263  393 YNeplqqPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQT----- 467

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 672035060 1157 tysLVAPKAQRPSPKAPQKVKAAIASIPVGSFESGTTGR 1195
Cdd:PRK10263  468 ---YQQPAAQEPLYQQPQPVEQQPVVEPEPVVEETKPAR 503
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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