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Conserved domains on  [gi|767910620|ref|XP_011508354|]
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high affinity immunoglobulin alpha and immunoglobulin mu Fc receptor isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 97-202 2.42e-26

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


:

Pssm-ID: 409381  Cd Length: 100  Bit Score: 102.86  E-value: 2.42e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910620  97 LKGSRLVSGEPGGAVTIQCHYAPSsvNRHQRKYWCRLGPprWICQTIVSTNQYTHHRyrdRVALTDFPQRGLFVVRLSQL 176
Cdd:cd05716    1 SVGPEVVTGVEGGSVTIQCPYPPK--YASSRKYWCKWGS--EGCQTLVSSEGVVPGG---RISLTDDPDNGVFTVTLNQL 73

                         90       100
                 ....*....|....*....|....*..
gi 767910620 177 SPDDIGCYLCGIGSEN-NMLFLSMNLT 202
Cdd:cd05716   74 RKEDAGWYWCGVGDDGdRGLTVQVKLV 100
DUF5585 super family cl39316
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 201-430 7.87e-03

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


The actual alignment was detected with superfamily member pfam17823:

Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 39.17  E-value: 7.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910620  201 LTISAGPASTLPTATPAAgelTMRSYGTASPVANRWTPGTTQTLGQGTAwDTVASTPGTSKTTASAEGRRTPGATRPAAP 280
Cdd:pfam17823  62 AATAAPAPVTLTKGTSAA---HLNSTEVTAEHTPHGTDLSEPATREGAA-DGAASRALAAAASSSPSSAAQSLPAAIAAL 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910620  281 GTGSWAEGSVKAPapipeSPPSKSRSMSNTTEGVWEGTRSSVTNRARASKDRREMTTTKADRPREdiegvrialdAAKKV 360
Cdd:pfam17823 138 PSEAFSAPRAAAC-----RANASAAPRAAIAAASAPHAASPAPRTAASSTTAASSTTAASSAPTT----------AASSA 202

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910620  361 LGTIGPPALVSETLAWEILPQATPVSKQqsqgsIGETTPAAGMWTLGTPAADVWILGTPAADVWTSMEAA 430
Cdd:pfam17823 203 PATLTPARGISTAATATGHPAAGTALAA-----VGNSSPAAGTVTAAVGTVTPAALATLAAAAGTVASAA 267
 
Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 97-202 2.42e-26

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 102.86  E-value: 2.42e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910620  97 LKGSRLVSGEPGGAVTIQCHYAPSsvNRHQRKYWCRLGPprWICQTIVSTNQYTHHRyrdRVALTDFPQRGLFVVRLSQL 176
Cdd:cd05716    1 SVGPEVVTGVEGGSVTIQCPYPPK--YASSRKYWCKWGS--EGCQTLVSSEGVVPGG---RISLTDDPDNGVFTVTLNQL 73

                         90       100
                 ....*....|....*....|....*..
gi 767910620 177 SPDDIGCYLCGIGSEN-NMLFLSMNLT 202
Cdd:cd05716   74 RKEDAGWYWCGVGDDGdRGLTVQVKLV 100
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 99-203 1.44e-18

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 81.35  E-value: 1.44e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910620   99 GSRLVSGEPGGAVTIQCHYAPSSVNRHQRKYWCRLGP---PRWICqtIVSTNQYTHHRYRDRVALTDFPQRGLFVVRLSQ 175
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTYSSSMSEASTSVYWYRQPPgkgPTFLI--AYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQN 79

                          90       100
                  ....*....|....*....|....*....
gi 767910620  176 LSPDDIGCYLCGIGSENNMLFLS-MNLTI 203
Cdd:pfam07686  80 LTLSDSGTYTCAVIPSGEGVFGKgTRLTV 108
IGv smart00406
Immunoglobulin V-Type;
111-186 5.29e-05

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 41.98  E-value: 5.29e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767910620   111 VTIQCHYAPSSVNRHQRkYWCRLGP---PRWICQTIVSTNQYTHHRYRDRVALTDFPQRGLFVVRLSQLSPDDIGCYLC 186
Cdd:smart00406   2 VTLSCKFSGSTFSSYYV-SWVRQPPgkgLEWLGYIGSNGSSYYQESYKGRFTISKDTSKNDVSLTISNLRVEDTGTYYC 79
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 201-430 7.87e-03

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 39.17  E-value: 7.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910620  201 LTISAGPASTLPTATPAAgelTMRSYGTASPVANRWTPGTTQTLGQGTAwDTVASTPGTSKTTASAEGRRTPGATRPAAP 280
Cdd:pfam17823  62 AATAAPAPVTLTKGTSAA---HLNSTEVTAEHTPHGTDLSEPATREGAA-DGAASRALAAAASSSPSSAAQSLPAAIAAL 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910620  281 GTGSWAEGSVKAPapipeSPPSKSRSMSNTTEGVWEGTRSSVTNRARASKDRREMTTTKADRPREdiegvrialdAAKKV 360
Cdd:pfam17823 138 PSEAFSAPRAAAC-----RANASAAPRAAIAAASAPHAASPAPRTAASSTTAASSTTAASSAPTT----------AASSA 202

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910620  361 LGTIGPPALVSETLAWEILPQATPVSKQqsqgsIGETTPAAGMWTLGTPAADVWILGTPAADVWTSMEAA 430
Cdd:pfam17823 203 PATLTPARGISTAATATGHPAAGTALAA-----VGNSSPAAGTVTAAVGTVTPAALATLAAAAGTVASAA 267
 
Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 97-202 2.42e-26

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 102.86  E-value: 2.42e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910620  97 LKGSRLVSGEPGGAVTIQCHYAPSsvNRHQRKYWCRLGPprWICQTIVSTNQYTHHRyrdRVALTDFPQRGLFVVRLSQL 176
Cdd:cd05716    1 SVGPEVVTGVEGGSVTIQCPYPPK--YASSRKYWCKWGS--EGCQTLVSSEGVVPGG---RISLTDDPDNGVFTVTLNQL 73

                         90       100
                 ....*....|....*....|....*..
gi 767910620 177 SPDDIGCYLCGIGSEN-NMLFLSMNLT 202
Cdd:cd05716   74 RKEDAGWYWCGVGDDGdRGLTVQVKLV 100
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 99-203 1.44e-18

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 81.35  E-value: 1.44e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910620   99 GSRLVSGEPGGAVTIQCHYAPSSVNRHQRKYWCRLGP---PRWICqtIVSTNQYTHHRYRDRVALTDFPQRGLFVVRLSQ 175
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTYSSSMSEASTSVYWYRQPPgkgPTFLI--AYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQN 79

                          90       100
                  ....*....|....*....|....*....
gi 767910620  176 LSPDDIGCYLCGIGSENNMLFLS-MNLTI 203
Cdd:pfam07686  80 LTLSDSGTYTCAVIPSGEGVFGKgTRLTV 108
IGv smart00406
Immunoglobulin V-Type;
111-186 5.29e-05

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 41.98  E-value: 5.29e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767910620   111 VTIQCHYAPSSVNRHQRkYWCRLGP---PRWICQTIVSTNQYTHHRYRDRVALTDFPQRGLFVVRLSQLSPDDIGCYLC 186
Cdd:smart00406   2 VTLSCKFSGSTFSSYYV-SWVRQPPgkgLEWLGYIGSNGSSYYQESYKGRFTISKDTSKNDVSLTISNLRVEDTGTYYC 79
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 100-203 6.83e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 41.72  E-value: 6.83e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910620   100 SRLVSGEPGGAVTIQCHYapsSVNRHQRKYWCRlGPPRWICqtivstnqythhrYRDRVALTdfPQRGLFVVRLSQLSPD 179
Cdd:smart00410   1 PPSVTVKEGESVTLSCEA---SGSPPPEVTWYK-QGGKLLA-------------ESGRFSVS--RSGSTSTLTISNVTPE 61

                           90       100
                   ....*....|....*....|....
gi 767910620   180 DIGCYLCGIGSENNMLFLSMNLTI 203
Cdd:smart00410  62 DSGTYTCAATNSSGSASSGTTLTV 85
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 201-430 7.87e-03

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 39.17  E-value: 7.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910620  201 LTISAGPASTLPTATPAAgelTMRSYGTASPVANRWTPGTTQTLGQGTAwDTVASTPGTSKTTASAEGRRTPGATRPAAP 280
Cdd:pfam17823  62 AATAAPAPVTLTKGTSAA---HLNSTEVTAEHTPHGTDLSEPATREGAA-DGAASRALAAAASSSPSSAAQSLPAAIAAL 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910620  281 GTGSWAEGSVKAPapipeSPPSKSRSMSNTTEGVWEGTRSSVTNRARASKDRREMTTTKADRPREdiegvrialdAAKKV 360
Cdd:pfam17823 138 PSEAFSAPRAAAC-----RANASAAPRAAIAAASAPHAASPAPRTAASSTTAASSTTAASSAPTT----------AASSA 202

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767910620  361 LGTIGPPALVSETLAWEILPQATPVSKQqsqgsIGETTPAAGMWTLGTPAADVWILGTPAADVWTSMEAA 430
Cdd:pfam17823 203 PATLTPARGISTAATATGHPAAGTALAA-----VGNSSPAAGTVTAAVGTVTPAALATLAAAAGTVASAA 267
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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