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Conserved domains on  [gi|767925593|ref|XP_011510673|]
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filamin A-interacting protein 1-like isoform X2 [Homo sapiens]

Protein Classification

coiled-coil domain-containing protein( domain architecture ID 1000095)

coiled-coil domain-containing protein contains a region with alpha-helical coiled-coil sequence signatures that is being annotated by a variety of protein family models, not necessarily indicating family membership

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
36-585 9.50e-19

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 92.04  E-value: 9.50e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593    36 RVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFH 115
Cdd:TIGR02168  233 RLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLA 312
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   116 QDQDTIM---AKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKIskgEYGNAGIMAEVEELRKRVL 192
Cdd:TIGR02168  313 NLERQLEeleAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEEL---ESRLEELEEQLETLRSKVA 389
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   193 DMEGK----DEELIKMEEQCRDLNKRLERET---------LQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCN 259
Cdd:TIGR02168  390 QLELQiaslNNEIERLEARLERLEDRRERLQqeieellkkLEEAELKELQAELEELEEELEELQEELERLEEALEELREE 469
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   260 LEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMF--------VDE--RKTMSEKL------ 323
Cdd:TIGR02168  470 LEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILgvlselisVDEgyEAAIEAALggrlqa 549
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   324 ---KKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKrALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNML 400
Cdd:TIGR02168  550 vvvENLNAAKKAIAFLKQNELGRVTFLPLDSIKGTE-IQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGVLVV 628
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   401 KNRLQSLE-AIEKDFLKNKLNQD--------------SGKSTTALHQENN-------------KIKELSQEVERLKLKLK 452
Cdd:TIGR02168  629 DDLDNALElAKKLRPGYRIVTLDgdlvrpggvitggsAKTNSSILERRREieeleekieeleeKIAELEKALAELRKELE 708
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   453 DMKAIEDDLMKTEDEYET----LERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLS 528
Cdd:TIGR02168  709 ELEEELEQLRKELEELSRqisaLRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELE 788
                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 767925593   529 REVDALKEkihEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELER 585
Cdd:TIGR02168  789 AQIEQLKE---ELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLED 842
 
Name Accession Description Interval E-value
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
36-585 9.50e-19

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 92.04  E-value: 9.50e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593    36 RVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFH 115
Cdd:TIGR02168  233 RLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLA 312
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   116 QDQDTIM---AKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKIskgEYGNAGIMAEVEELRKRVL 192
Cdd:TIGR02168  313 NLERQLEeleAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEEL---ESRLEELEEQLETLRSKVA 389
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   193 DMEGK----DEELIKMEEQCRDLNKRLERET---------LQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCN 259
Cdd:TIGR02168  390 QLELQiaslNNEIERLEARLERLEDRRERLQqeieellkkLEEAELKELQAELEELEEELEELQEELERLEEALEELREE 469
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   260 LEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMF--------VDE--RKTMSEKL------ 323
Cdd:TIGR02168  470 LEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILgvlselisVDEgyEAAIEAALggrlqa 549
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   324 ---KKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKrALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNML 400
Cdd:TIGR02168  550 vvvENLNAAKKAIAFLKQNELGRVTFLPLDSIKGTE-IQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGVLVV 628
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   401 KNRLQSLE-AIEKDFLKNKLNQD--------------SGKSTTALHQENN-------------KIKELSQEVERLKLKLK 452
Cdd:TIGR02168  629 DDLDNALElAKKLRPGYRIVTLDgdlvrpggvitggsAKTNSSILERRREieeleekieeleeKIAELEKALAELRKELE 708
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   453 DMKAIEDDLMKTEDEYET----LERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLS 528
Cdd:TIGR02168  709 ELEEELEQLRKELEELSRqisaLRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELE 788
                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 767925593   529 REVDALKEkihEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELER 585
Cdd:TIGR02168  789 AQIEQLKE---ELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLED 842
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
36-579 1.28e-17

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 88.46  E-value: 1.28e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  36 RVTTLKEELTKLKSFALmvVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFH 115
Cdd:COG1196  214 RYRELKEELKELEAELL--LLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEY 291
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 116 QDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDME 195
Cdd:COG1196  292 ELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAE 371
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 196 GKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEK--------LSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTT 267
Cdd:COG1196  372 AELAEAEEELEELAEELLEALRAAAELAAQLEELEEaeeallerLERLEEELEELEEALAELEEEEEEEEEALEEAAEEE 451
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 268 KQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSE-----KLKKTEDKLQAASSQLQVEQn 342
Cdd:COG1196  452 AELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGflegvKAALLLAGLRGLAGAVAVLI- 530
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 343 KVTTVTEKLIEETKRALkSKTDVEEKMYSVTKERDDLK------------NKLKAEEEKGNDLLSRVNMLKNRLQSLEAI 410
Cdd:COG1196  531 GVEAAYEAALEAALAAA-LQNIVVEDDEVAAAAIEYLKaakagratflplDKIRARAALAAALARGAIGAAVDLVASDLR 609
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 411 EKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELE 490
Cdd:COG1196  610 EADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLA 689
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 491 HVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQK-KLNQQENRN 569
Cdd:COG1196  690 EEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPpDLEELEREL 769
                        570
                 ....*....|
gi 767925593 570 RDLGREIENL 579
Cdd:COG1196  770 ERLEREIEAL 779
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
19-543 2.35e-17

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 87.43  E-value: 2.35e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  19 IDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTA----------QLTLQRQKIQELTTNAKETHTKLAL 88
Cdd:PRK03918 191 IEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEElkeeieelekELESLEGSKRKLEEKIRELEERIEE 270
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  89 AEARVQEEEQKATRLE--KELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDI 166
Cdd:PRK03918 271 LKKEIEELEEKVKELKelKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKEL 350
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 167 KEKISKGE-----YGNA-GIMAEVEELRKRVldmegKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALE 240
Cdd:PRK03918 351 EKRLEELEerhelYEEAkAKKEELERLKKRL-----TGLTPEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELK 425
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 241 KLEDAFNKSKQECYSLKCNL--EKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVM--FVDER 316
Cdd:PRK03918 426 KAIEELKKAKGKCPVCGRELteEHRKELLEEYTAELKRIEKELKEIEEKERKLRKELRELEKVLKKESELIKLkeLAEQL 505
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 317 KTMSEKLKKTE-DKLQAASSQLQVEQNKVTTVT------EKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLkaeEEK 389
Cdd:PRK03918 506 KELEEKLKKYNlEELEKKAEEYEKLKEKLIKLKgeikslKKELEKLEELKKKLAELEKKLDELEEELAELLKEL---EEL 582
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 390 GndlLSRVNMLKNRLQSLEAIEKDFLKNK--------LNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAI--ED 459
Cdd:PRK03918 583 G---FESVEELEERLKELEPFYNEYLELKdaekelerEEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKysEE 659
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 460 DLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKlAEKTEtsheqwlFKRLQEEEAKSGHLSREVDALKEKIH 539
Cdd:PRK03918 660 EYEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLK-EELEE-------REKAKKELEKLEKALERVEELREKVK 731

                 ....
gi 767925593 540 EYMA 543
Cdd:PRK03918 732 KYKA 735
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
36-589 4.89e-10

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 63.70  E-value: 4.89e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593    36 RVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEeeqKATRLEKELQTQTTKFH 115
Cdd:pfam12128  242 EFTKLQQEFNTLESAELRLSHLHFGYKSDETLIASRQEERQETSAELNQLLRTLDDQWKE---KRDELNGELSAADAAVA 318
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   116 QDQdtimAKLTNEDSQNRQLQQ----KLAALSRQID----ELEETNRSLRKAEEELQDIKEKIskgeygNAGIMAEVEEL 187
Cdd:pfam12128  319 KDR----SELEALEDQHGAFLDadieTAAADQEQLPswqsELENLEERLKALTGKHQDVTAKY------NRRRSKIKEQN 388
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   188 rkrVLDMEGKDEELIKMEEQcRDLNKRLERETLQSKDFKLEveklskrimalEKLEDAFNKSKQECYSLKCNLEKERMTT 267
Cdd:pfam12128  389 ---NRDIAGIKDKLAKIREA-RDRQLAVAEDDLQALESELR-----------EQLEAGKLEFNEEEYRLKSRLGELKLRL 453
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   268 KQL---SQELESLKVRIKELEAIESRLEKTeFTLKEDLTklktltvmfvDERKTMSEKLKKTEDKLQAASSQLQVEQNKV 344
Cdd:pfam12128  454 NQAtatPELLLQLENFDERIERAREEQEAA-NAEVERLQ----------SELRQARKRRDQASEALRQASRRLEERQSAL 522
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   345 TTVTEKLIEETKRAL----KSKTDVEEKMYSVTKE----RDDLKNKLKAEEEKGNDLLSRVNMlknRLQSLEAIEKDFLK 416
Cdd:pfam12128  523 DELELQLFPQAGTLLhflrKEAPDWEQSIGKVISPellhRTDLDPEVWDGSVGGELNLYGVKL---DLKRIDVPEWAASE 599
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   417 NKLNQDSGKSTTALHQENNKIKELSQ-------EVERLKLKLKDMKAI----EDDLMKTEDEYETLERR----YANERDK 481
Cdd:pfam12128  600 EELRERLDKAEEALQSAREKQAAAEEqlvqangELEKASREETFARTAlknaRLDLRRLFDEKQSEKDKknkaLAERKDS 679
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   482 AQFLSKELEHVKMELA---KYKLAEKTETSHE---QWLFKRLQEEEAKSGHLSReVDALKEKIHEYMATEDLICHLQGDH 555
Cdd:pfam12128  680 ANERLNSLEAQLKQLDkkhQAWLEEQKEQKREartEKQAYWQVVEGALDAQLAL-LKAAIAARRSGAKAELKALETWYKR 758
                          570       580       590
                   ....*....|....*....|....*....|....
gi 767925593   556 SVlqKKLNQQENRNRDLGREIENLTKELERYRHF 589
Cdd:pfam12128  759 DL--ASLGVDPDVIAKLKREIRTLERKIERIAVR 790
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
103-242 1.41e-03

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 41.93  E-value: 1.41e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   103 LEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKA-EEELQDIKEKISKGEYGNAGIM 181
Cdd:smart00787 145 LKEGLDENLEGLKEDYKLLMKELELLNSIKPKLRDRKDALEEELRQLKQLEDELEDCdPTELDRAKEKLKKLLQEIMIKV 224
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767925593   182 AEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKL-EVEKLSKRIMALEKL 242
Cdd:smart00787 225 KKLEELEEELQELESKIEDLTNKKSELNTEIAEAEKKLEQCRGFTFkEIEKLKEQLKLLQSL 286
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
128-483 9.95e-03

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 39.61  E-value: 9.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 128 EDSQNRQLQQKLAALSRQIdeLEETNRSLRKAEEEL-QDIKEKISkgeygnagimAEVEELRKRVLDMEGKDEELIKMEE 206
Cdd:NF033838  82 KHTQNVALNKKLSDIKTEY--LYELNVLKEKSEAELtSKTKKELD----------AAFEQFKKDTLEPGKKVAEATKKVE 149
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 207 QCRDLNKRLERE------TLQSKDFKLEVEKLSKRImalekledafNKSKQECYSLKCNLEKERMTTKQLSQELESLKVR 280
Cdd:NF033838 150 EAEKKAKDQKEEdrrnypTNTYKTLELEIAESDVEV----------KKAELELVKEEAKEPRDEEKIKQAKAKVESKKAE 219
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 281 IKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALK 360
Cdd:NF033838 220 ATRLEKIKTDREKAEEEAKRRADAKLKEAVEKNVATSEQDKPKRRAKRGVLGEPATPDKKENDAKSSDSSVGEETLPSPS 299
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 361 SKTdvEEKMYSVTKERDDLKNKLKAEEEKgndllSRVNMLKNRLQSL--EAIEKDFLKNKLNQDSGKSTTALHQENNKIK 438
Cdd:NF033838 300 LKP--EKKVAEAEKKVEEAKKKAKDQKEE-----DRRNYPTNTYKTLelEIAESDVKVKEAELELVKEEAKEPRNEEKIK 372
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 767925593 439 ELSQEVERLKLKLKDMKAIEDDLMKTEDEyetlERRYANERDKAQ 483
Cdd:NF033838 373 QAKAKVESKKAEATRLEKIKTDRKKAEEE----AKRKAAEEDKVK 413
 
Name Accession Description Interval E-value
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
36-585 9.50e-19

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 92.04  E-value: 9.50e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593    36 RVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFH 115
Cdd:TIGR02168  233 RLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLA 312
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   116 QDQDTIM---AKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKIskgEYGNAGIMAEVEELRKRVL 192
Cdd:TIGR02168  313 NLERQLEeleAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEEL---ESRLEELEEQLETLRSKVA 389
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   193 DMEGK----DEELIKMEEQCRDLNKRLERET---------LQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCN 259
Cdd:TIGR02168  390 QLELQiaslNNEIERLEARLERLEDRRERLQqeieellkkLEEAELKELQAELEELEEELEELQEELERLEEALEELREE 469
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   260 LEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMF--------VDE--RKTMSEKL------ 323
Cdd:TIGR02168  470 LEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILgvlselisVDEgyEAAIEAALggrlqa 549
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   324 ---KKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKrALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNML 400
Cdd:TIGR02168  550 vvvENLNAAKKAIAFLKQNELGRVTFLPLDSIKGTE-IQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGVLVV 628
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   401 KNRLQSLE-AIEKDFLKNKLNQD--------------SGKSTTALHQENN-------------KIKELSQEVERLKLKLK 452
Cdd:TIGR02168  629 DDLDNALElAKKLRPGYRIVTLDgdlvrpggvitggsAKTNSSILERRREieeleekieeleeKIAELEKALAELRKELE 708
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   453 DMKAIEDDLMKTEDEYET----LERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLS 528
Cdd:TIGR02168  709 ELEEELEQLRKELEELSRqisaLRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELE 788
                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 767925593   529 REVDALKEkihEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELER 585
Cdd:TIGR02168  789 AQIEQLKE---ELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLED 842
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
36-579 1.28e-17

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 88.46  E-value: 1.28e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  36 RVTTLKEELTKLKSFALmvVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFH 115
Cdd:COG1196  214 RYRELKEELKELEAELL--LLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEY 291
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 116 QDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDME 195
Cdd:COG1196  292 ELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAE 371
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 196 GKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEK--------LSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTT 267
Cdd:COG1196  372 AELAEAEEELEELAEELLEALRAAAELAAQLEELEEaeeallerLERLEEELEELEEALAELEEEEEEEEEALEEAAEEE 451
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 268 KQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSE-----KLKKTEDKLQAASSQLQVEQn 342
Cdd:COG1196  452 AELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGflegvKAALLLAGLRGLAGAVAVLI- 530
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 343 KVTTVTEKLIEETKRALkSKTDVEEKMYSVTKERDDLK------------NKLKAEEEKGNDLLSRVNMLKNRLQSLEAI 410
Cdd:COG1196  531 GVEAAYEAALEAALAAA-LQNIVVEDDEVAAAAIEYLKaakagratflplDKIRARAALAAALARGAIGAAVDLVASDLR 609
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 411 EKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELE 490
Cdd:COG1196  610 EADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLA 689
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 491 HVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGDHSVLQK-KLNQQENRN 569
Cdd:COG1196  690 EEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPpDLEELEREL 769
                        570
                 ....*....|
gi 767925593 570 RDLGREIENL 579
Cdd:COG1196  770 ERLEREIEAL 779
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
19-543 2.35e-17

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 87.43  E-value: 2.35e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  19 IDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTA----------QLTLQRQKIQELTTNAKETHTKLAL 88
Cdd:PRK03918 191 IEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEElkeeieelekELESLEGSKRKLEEKIRELEERIEE 270
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  89 AEARVQEEEQKATRLE--KELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDI 166
Cdd:PRK03918 271 LKKEIEELEEKVKELKelKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKEL 350
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 167 KEKISKGE-----YGNA-GIMAEVEELRKRVldmegKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALE 240
Cdd:PRK03918 351 EKRLEELEerhelYEEAkAKKEELERLKKRL-----TGLTPEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELK 425
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 241 KLEDAFNKSKQECYSLKCNL--EKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVM--FVDER 316
Cdd:PRK03918 426 KAIEELKKAKGKCPVCGRELteEHRKELLEEYTAELKRIEKELKEIEEKERKLRKELRELEKVLKKESELIKLkeLAEQL 505
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 317 KTMSEKLKKTE-DKLQAASSQLQVEQNKVTTVT------EKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLkaeEEK 389
Cdd:PRK03918 506 KELEEKLKKYNlEELEKKAEEYEKLKEKLIKLKgeikslKKELEKLEELKKKLAELEKKLDELEEELAELLKEL---EEL 582
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 390 GndlLSRVNMLKNRLQSLEAIEKDFLKNK--------LNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAI--ED 459
Cdd:PRK03918 583 G---FESVEELEERLKELEPFYNEYLELKdaekelerEEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKysEE 659
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 460 DLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKlAEKTEtsheqwlFKRLQEEEAKSGHLSREVDALKEKIH 539
Cdd:PRK03918 660 EYEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLK-EELEE-------REKAKKELEKLEKALERVEELREKVK 731

                 ....
gi 767925593 540 EYMA 543
Cdd:PRK03918 732 KYKA 735
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
133-584 1.99e-15

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 81.26  E-value: 1.99e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 133 RQLQQKLAALSRQIDELEET-------NRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELR---KRVLDMEGKDEELI 202
Cdd:PRK03918 217 PELREELEKLEKEVKELEELkeeieelEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEekvKELKELKEKAEEYI 296
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 203 KMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLE------KERMTTKQLSQELES 276
Cdd:PRK03918 297 KLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEeleerhELYEEAKAKKEELER 376
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 277 LKVRIK--ELEAIESRLEKTEFTLKEDLTKLKTLTVMF------VDERKTMSEKLKKTEDKLQAASSQLQVEQNKvtTVT 348
Cdd:PRK03918 377 LKKRLTglTPEKLEKELEELEKAKEEIEEEISKITARIgelkkeIKELKKAIEELKKAKGKCPVCGRELTEEHRK--ELL 454
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 349 EKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEE--KGNDLLSRVNMLKNRLQS--LEAIEKDF-----LKNKL 419
Cdd:PRK03918 455 EEYTAELKRIEKELKEIEEKERKLRKELRELEKVLKKESEliKLKELAEQLKELEEKLKKynLEELEKKAeeyekLKEKL 534
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 420 NQDSGKSTTaLHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDE-----YETLERR------YANERDKAQFLSKE 488
Cdd:PRK03918 535 IKLKGEIKS-LKKELEKLEELKKKLAELEKKLDELEEELAELLKELEElgfesVEELEERlkelepFYNEYLELKDAEKE 613
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 489 LEHVKMELAkyKLAEKTETSheqwlFKRLQEEEAKSGHLSREVDALKEKI--HEYMATEDLICHLQGDHSVLQKKLNQQE 566
Cdd:PRK03918 614 LEREEKELK--KLEEELDKA-----FEELAETEKRLEELRKELEELEKKYseEEYEELREEYLELSRELAGLRAELEELE 686
                        490
                 ....*....|....*...
gi 767925593 567 NRNRDLGREIENLTKELE 584
Cdd:PRK03918 687 KRREEIKKTLEKLKEELE 704
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
118-584 1.56e-14

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 78.18  E-value: 1.56e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 118 QDTIMAKLTNEDSQNRQLQQKLaalsrQIDELEETNRSLRKAEEELQDIKEKISKgeygnagIMAEVEELRKRVLDMEgk 197
Cdd:PRK03918 134 QGEIDAILESDESREKVVRQIL-----GLDDYENAYKNLGEVIKEIKRRIERLEK-------FIKRTENIEELIKEKE-- 199
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 198 dEELIKMEEQCRDLNKRLEretlqskDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESL 277
Cdd:PRK03918 200 -KELEEVLREINEISSELP-------ELREELEKLEKEVKELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEEL 271
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 278 KVRIKELEAIESRLEKTEftlkedltklktltvmfvdERKTMSEKLKKTEDKLQAASSQLQVEQNKVttvtEKLIEETKR 357
Cdd:PRK03918 272 KKEIEELEEKVKELKELK-------------------EKAEEYIKLSEFYEEYLDELREIEKRLSRL----EEEINGIEE 328
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 358 ALKSKTDVEEKMYSVTKERDDLKNKLkAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKI 437
Cdd:PRK03918 329 RIKELEEKEERLEELKKKLKELEKRL-EELEERHELYEEAKAKKEELERLKKRLTGLTPEKLEKELEELEKAKEEIEEEI 407
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 438 KELSQEVERLKLKLKDMKAIEDDLMK------------TEDEYETLERRY-------ANERDKAQFLSKELEHVKMELAK 498
Cdd:PRK03918 408 SKITARIGELKKEIKELKKAIEELKKakgkcpvcgrelTEEHRKELLEEYtaelkriEKELKEIEEKERKLRKELRELEK 487
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 499 yKLAEKTETSHEQWLFKRLQEEEAKSGHLSREvdALKEKIHEYMATEDLICHLQGDHSVLQ---KKLNQQENRNRDLGRE 575
Cdd:PRK03918 488 -VLKKESELIKLKELAEQLKELEEKLKKYNLE--ELEKKAEEYEKLKEKLIKLKGEIKSLKkelEKLEELKKKLAELEKK 564

                 ....*....
gi 767925593 576 IENLTKELE 584
Cdd:PRK03918 565 LDELEEELA 573
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
20-379 8.00e-14

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 76.25  E-value: 8.00e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593    20 DQEIKSQEEKEQEKEKRVTTLKEELTKLKsfalmvvDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQK 99
Cdd:TIGR02168  676 RREIEELEEKIEELEEKIAELEKALAELR-------KELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEER 748
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   100 ATRLEKE---LQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETnrsLRKAEEELQDIKEKISKGEYG 176
Cdd:TIGR02168  749 IAQLSKElteLEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREA---LDELRAELTLLNEEAANLRER 825
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   177 NAGIMAEVEELRKRVLDMEgkdEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSL 256
Cdd:TIGR02168  826 LESLERRIAATERRLEDLE---EQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEE 902
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   257 KCNLEKERMTTKQLSQELEslkvriKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQ 336
Cdd:TIGR02168  903 LRELESKRSELRRELEELR------EKLAQLELRLEGLEVRIDNLQERLSEEYSLTLEEAEALENKIEDDEEEARRRLKR 976
                          330       340       350       360
                   ....*....|....*....|....*....|....*....|...
gi 767925593   337 LQVEQNKVTTVTEKLIEETKralksktDVEEKMYSVTKERDDL 379
Cdd:TIGR02168  977 LENKIKELGPVNLAAIEEYE-------ELKERYDFLTAQKEDL 1012
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
151-503 1.05e-13

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 75.86  E-value: 1.05e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   151 ETNRSLRKAEEELQDIKEKISKGEygnagimAEVEELRKRVLDME----GKDEELIKMEEQCRDLNKRLERETLQSKDFK 226
Cdd:TIGR02168  674 ERRREIEELEEKIEELEEKIAELE-------KALAELRKELEELEeeleQLRKELEELSRQISALRKDLARLEAEVEQLE 746
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   227 LEVEKLSKRIMAL----EKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDL 302
Cdd:TIGR02168  747 ERIAQLSKELTELeaeiEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERL 826
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   303 TKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSqlqvEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNK 382
Cdd:TIGR02168  827 ESLERRIAATERRLEDLEEQIEELSEDIESLAA----EIEELEELIEELESELEALLNERASLEEALALLRSELEELSEE 902
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   383 LKAEEEKGNDLL-------SRVNMLKNRLQSLEAiEKDFLKNKLNQDsGKSTTALHQEN-----NKIKELSQEVERLKLK 450
Cdd:TIGR02168  903 LRELESKRSELRreleelrEKLAQLELRLEGLEV-RIDNLQERLSEE-YSLTLEEAEALenkieDDEEEARRRLKRLENK 980
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|...
gi 767925593   451 LKDMKAIEddlMKTEDEYETLERRYanerdkaQFLSKELEHVkmELAKYKLAE 503
Cdd:TIGR02168  981 IKELGPVN---LAAIEEYEELKERY-------DFLTAQKEDL--TEAKETLEE 1021
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
95-499 2.81e-13

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 74.33  E-value: 2.81e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593    95 EEEQKATRLEKELQtqttKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDEL----EETNRSLRKAEEELQDIKEKI 170
Cdd:TIGR02169  671 SEPAELQRLRERLE----GLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIekeiEQLEQEEEKLKERLEELEEDL 746
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   171 SKGEYGNAGIMAEVEELRKRVLDMEgkdEELIKMEEQCRDLNKRLERETLQSKDFKL-EVEKLSKRIMA-LEKLEDAFNK 248
Cdd:TIGR02169  747 SSLEQEIENVKSELKELEARIEELE---EDLHKLEEALNDLEARLSHSRIPEIQAELsKLEEEVSRIEArLREIEQKLNR 823
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   249 SKQEcyslKCNLEKERMTTKQLSQELESLKVRI-KELEAIESRLEKTEFTLKEDLTKLKTLtvmfvDERKtmsEKLKKTE 327
Cdd:TIGR02169  824 LTLE----KEYLEKEIQELQEQRIDLKEQIKSIeKEIENLNGKKEELEEELEELEAALRDL-----ESRL---GDLKKER 891
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   328 DKLQAASSQLQVEQNKvttvteklieetkralksktdveekmysvtkerddlknkLKAEEEKGNDLLSRvnmLKNRLQSL 407
Cdd:TIGR02169  892 DELEAQLRELERKIEE---------------------------------------LEAQIEKKRKRLSE---LKAKLEAL 929
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   408 EAIEKDFLKNKlnqDSGKSTTALHQENNKIKELSQEVERlklklkDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSK 487
Cdd:TIGR02169  930 EEELSEIEDPK---GEDEEIPEEELSLEDVQAELQRVEE------EIRALEPVNMLAIQEYEEVLKRLDELKEKRAKLEE 1000
                          410
                   ....*....|..
gi 767925593   488 ELEHVKMELAKY 499
Cdd:TIGR02169 1001 ERKAILERIEEY 1012
PTZ00121 PTZ00121
MAEBL; Provisional
90-611 4.32e-13

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 74.02  E-value: 4.32e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   90 EARVQEEEQKATRLEKelqTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRslRKAEEeLQDIKEK 169
Cdd:PTZ00121 1216 EARKAEDAKKAEAVKK---AEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEA--RKADE-LKKAEEK 1289
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  170 ISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEE---QCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAF 246
Cdd:PTZ00121 1290 KKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEakkKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAA 1369
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  247 NKSKQECYSLKCNLEK---ERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLK--EDLTKLKTLTVMfVDERKTMSE 321
Cdd:PTZ00121 1370 EKKKEEAKKKADAAKKkaeEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKkaEEKKKADEAKKK-AEEAKKADE 1448
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  322 KLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLK 401
Cdd:PTZ00121 1449 AKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAK 1528
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  402 NRLQSLEAIEKDFLKNKLNQDSGKSTTALH--QENNKIKELSQEVERLKLKLK---DMKAIE----DDLMKTEDEYETLE 472
Cdd:PTZ00121 1529 KAEEAKKADEAKKAEEKKKADELKKAEELKkaEEKKKAEEAKKAEEDKNMALRkaeEAKKAEeariEEVMKLYEEEKKMK 1608
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  473 ----RRYANERDKAQFLSKElEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDli 548
Cdd:PTZ00121 1609 aeeaKKAEEAKIKAEELKKA-EEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEE-- 1685
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767925593  549 chlqgdhsvLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSLNGRRISDPQVFSKE 611
Cdd:PTZ00121 1686 ---------DEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEA 1739
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
45-389 2.05e-12

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 71.64  E-value: 2.05e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593    45 TKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQ---DQDTI 121
Cdd:TIGR02169  670 RSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEEleeDLSSL 749
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   122 MAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSL--RKAEEELQDIKEKISKgeygnagIMAEVEELRKRVLDMEGKDE 199
Cdd:TIGR02169  750 EQEIENVKSELKELEARIEELEEDLHKLEEALNDLeaRLSHSRIPEIQAELSK-------LEEEVSRIEARLREIEQKLN 822
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   200 ELIKMEEQCRDLNKRLERE----TLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERmttKQLSQELE 275
Cdd:TIGR02169  823 RLTLEKEYLEKEIQELQEQridlKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKER---DELEAQLR 899
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   276 SLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKT--EDKLQAASSQLQVEQNKVTTVTEKLIE 353
Cdd:TIGR02169  900 ELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEEIPEEElsLEDVQAELQRVEEEIRALEPVNMLAIQ 979
                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 767925593   354 ETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEK 389
Cdd:TIGR02169  980 EYEEVLKRLDELKEKRAKLEEERKAILERIEEYEKK 1015
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
20-410 6.52e-12

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 69.68  E-value: 6.52e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  20 DQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQK 99
Cdd:PRK02224 306 DADAEAVEARREELEDRDEELRDRLEECRVAAQAHNEEAESLREDADDLEERAEELREEAAELESELEEAREAVEDRREE 385
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 100 ATRLEKELQTQTTKFhqdqDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYG--- 176
Cdd:PRK02224 386 IEELEEEIEELRERF----GDAPVDLGNAEDFLEELREERDELREREAELEATLRTARERVEEAEALLEAGKCPECGqpv 461
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 177 -NAGIMAEVEELRKRVLDMEgkdEELIKMEEQCRDLNKRLER-----------ETLQSK---------DFKLEVEKLSKR 235
Cdd:PRK02224 462 eGSPHVETIEEDRERVEELE---AELEDLEEEVEEVEERLERaedlveaedriERLEERredleeliaERRETIEEKRER 538
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 236 IMAL----EKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEfTLKEDLTKLKtltvm 311
Cdd:PRK02224 539 AEELreraAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERIESLERIRTLLAAIA-DAEDEIERLR----- 612
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 312 fvDERKTMSEKLKKTEDKLQAAS---SQL--QVEQNKVttvtEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNK---L 383
Cdd:PRK02224 613 --EKREALAELNDERRERLAEKRerkRELeaEFDEARI----EEAREDKERAEEYLEQVEEKLDELREERDDLQAEigaV 686
                        410       420
                 ....*....|....*....|....*..
gi 767925593 384 KAEEEKGNDLLSRVNMLKNRLQSLEAI 410
Cdd:PRK02224 687 ENELEELEELRERREALENRVEALEAL 713
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
146-520 1.92e-11

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 68.17  E-value: 1.92e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   146 IDEL---EETNRSLRKAEEELQDIKEKISKgeygnagIMAEVEELRKRVLDMEGKDEELIKMeeqcRDLNKRLEretlqs 222
Cdd:TIGR02169  159 IDEIagvAEFDRKKEKALEELEEVEENIER-------LDLIIDEKRQQLERLRREREKAERY----QALLKEKR------ 221
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   223 kdfKLEVEKLSKRIMALEKledafnkskqecyslkcnlEKERmTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDL 302
Cdd:TIGR02169  222 ---EYEGYELLKEKEALER-------------------QKEA-IERQLASLEEELEKLTEEISELEKRLEEIEQLLEELN 278
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   303 TKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNK 382
Cdd:TIGR02169  279 KKIKDLGEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEE 358
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   383 LKAEEEKGNDLLSRVNMLKNRLQSL------EAIEKDFLKNKLN----------QDSGKSTTALHQENNKIKELSQEV-- 444
Cdd:TIGR02169  359 YAELKEELEDLRAELEEVDKEFAETrdelkdYREKLEKLKREINelkreldrlqEELQRLSEELADLNAAIAGIEAKIne 438
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767925593   445 --ERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKyKLAEKTETSHEQWLFKRLQEE 520
Cdd:TIGR02169  439 leEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAE-AEAQARASEERVRGGRAVEEV 515
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
133-490 3.37e-11

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 67.39  E-value: 3.37e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   133 RQLQQKLAALSRQIDELEETNRSLRKAE------EELQDIKEKISKGEYGNAGimAEVEELRKRvldMEGKDEELIKMEE 206
Cdd:TIGR02168  179 RKLERTRENLDRLEDILNELERQLKSLErqaekaERYKELKAELRELELALLV--LRLEELREE---LEELQEELKEAEE 253
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   207 QCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKledafnkskqECYSLKCNLEKERMTTKQLSQELESLKVRIKELEA 286
Cdd:TIGR02168  254 ELEELTAELQELEEKLEELRLEVSELEEEIEELQK----------ELYALANEISRLEQQKQILRERLANLERQLEELEA 323
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   287 IESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEetkralksktdVE 366
Cdd:TIGR02168  324 QLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQ-----------LE 392
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   367 EKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVER 446
Cdd:TIGR02168  393 LQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEE 472
                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....
gi 767925593   447 LKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELE 490
Cdd:TIGR02168  473 AEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQS 516
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
64-599 1.06e-10

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 65.86  E-value: 1.06e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593    64 QLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFH---QDQDTIMAKLTNE-DSQNRQLQQKL 139
Cdd:TIGR02169  217 LKEKREYEGYELLKEKEALERQKEAIERQLASLEEELEKLTEEISELEKRLEeieQLLEELNKKIKDLgEEEQLRVKEKI 296
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   140 AALSRQI----DELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEgkdEELIKMEEQCRDLNKRL 215
Cdd:TIGR02169  297 GELEAEIasleRSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLT---EEYAELKEELEDLRAEL 373
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   216 EREtlqSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEaieSRLEKTE 295
Cdd:TIGR02169  374 EEV---DKEFAETRDELKDYREKLEKLKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELE---EEKEDKA 447
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   296 FTLKEDLTKLKTLTVMFVDERKTM---SEKLKKTEDKLQAASSQL-------------QVEQNKVTTVTEKLIEETKRAL 359
Cdd:TIGR02169  448 LEIKKQEWKLEQLAADLSKYEQELydlKEEYDRVEKELSKLQRELaeaeaqaraseerVRGGRAVEEVLKASIQGVHGTV 527
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   360 KSKTDVEEK------------MYSVTKERDD--------LK------------NKLKAEE-------------------- 387
Cdd:TIGR02169  528 AQLGSVGERyataievaagnrLNNVVVEDDAvakeaielLKrrkagratflplNKMRDERrdlsilsedgvigfavdlve 607
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   388 ----------------------EKGNDLLSRVNM------------------------------LKNRLQSLEAiEKDFL 415
Cdd:TIGR02169  608 fdpkyepafkyvfgdtlvvediEAARRLMGKYRMvtlegelfeksgamtggsraprggilfsrsEPAELQRLRE-RLEGL 686
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   416 KNKLNqdsgksttALHQENNKIK----ELSQEVERLKLKLKDmkaIEDDLMKTEDEYETLERRYANERDKAQFLSKELEH 491
Cdd:TIGR02169  687 KRELS--------SLQSELRRIEnrldELSQELSDASRKIGE---IEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIEN 755
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   492 VKMELAKY--KLAEKTETSHEqwLFKRLQEEEAK-SGHLSREVDALKEKIHEYMA--------TEDLICHLQGDHSVLQK 560
Cdd:TIGR02169  756 VKSELKELeaRIEELEEDLHK--LEEALNDLEARlSHSRIPEIQAELSKLEEEVSriearlreIEQKLNRLTLEKEYLEK 833
                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|...
gi 767925593   561 KLNQQENRNRDL-------GREIENLTK-------ELERYRHFSKSLRPSLNG 599
Cdd:TIGR02169  834 EIQELQEQRIDLkeqiksiEKEIENLNGkkeeleeELEELEAALRDLESRLGD 886
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
90-506 1.60e-10

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 65.06  E-value: 1.60e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  90 EARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEK 169
Cdd:PRK02224 187 GSLDQLKAQIEEKEEKDLHERLNGLESELAELDEEIERYEEQREQARETRDEADEVLEEHEERREELETLEAEIEDLRET 266
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 170 ISKGEYGNAGIMAEVEELRKRVLDMEGKD---------------------EELIKMEEQCRDlnkRLERETLQSKDFKLE 228
Cdd:PRK02224 267 IAETEREREELAEEVRDLRERLEELEEERddllaeaglddadaeavearrEELEDRDEELRD---RLEECRVAAQAHNEE 343
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 229 VEKLSKRIMALE----KLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIK----ELEAIESRLEKTEFTLKE 300
Cdd:PRK02224 344 AESLREDADDLEeraeELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFGdapvDLGNAEDFLEELREERDE 423
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 301 DLTKLKTLTVmfvdERKTMSEKLKKTEDKLQAAS--------------SQLQVEQNKVTTVTEKL--IEETKRALKSKTD 364
Cdd:PRK02224 424 LREREAELEA----TLRTARERVEEAEALLEAGKcpecgqpvegsphvETIEEDRERVEELEAELedLEEEVEEVEERLE 499
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 365 VEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAiEKDFLKNKLnQDSGKSTTALHQENNK----IKEL 440
Cdd:PRK02224 500 RAEDLVEAEDRIERLEERREDLEELIAERRETIEEKRERAEELRE-RAAELEAEA-EEKREAAAEAEEEAEEareeVAEL 577
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767925593 441 SQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRyaNERDKAQflsKELEhvkmELAKYKLAEKTE 506
Cdd:PRK02224 578 NSKLAELKERIESLERIRTLLAAIADAEDEIERL--REKREAL---AELN----DERRERLAEKRE 634
PTZ00121 PTZ00121
MAEBL; Provisional
68-583 1.69e-10

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 65.55  E-value: 1.69e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   68 QRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMA--KLTNEDSQNRQLQQKLAALSRQ 145
Cdd:PTZ00121 1313 EAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAaeKKKEEAKKKADAAKKKAEEKKK 1392
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  146 IDELEETNRSLRKAEEELQDIKEKISKGEYGN--AGIMAEVEELRKRVLDMEGKDEELIKMEEqcrdlnKRLERETLQSK 223
Cdd:PTZ00121 1393 ADEAKKKAEEDKKKADELKKAAAAKKKADEAKkkAEEKKKADEAKKKAEEAKKADEAKKKAEE------AKKAEEAKKKA 1466
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  224 DFKLEVEKLSKRIMALEKLEDAfnKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLT 303
Cdd:PTZ00121 1467 EEAKKADEAKKKAEEAKKADEA--KKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEE 1544
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  304 KLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTtvteKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKL 383
Cdd:PTZ00121 1545 KKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEA----KKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKI 1620
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  384 KAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKlnqdsgksttalhQENNKIK--ELSQEVERLKLKLKDMKAIEDDL 461
Cdd:PTZ00121 1621 KAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKA-------------EEENKIKaaEEAKKAEEDKKKAEEAKKAEEDE 1687
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  462 MKTEDEYetleRRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLfKRLQEEEAKSGHLSREVDALKEKIHEY 541
Cdd:PTZ00121 1688 KKAAEAL----KKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEA-KKEAEEDKKKAEEAKKDEEEKKKIAHL 1762
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....
gi 767925593  542 MATEDLICH--LQGDHSVLQKKLNQQENRNRdlgREIENLTKEL 583
Cdd:PTZ00121 1763 KKEEEKKAEeiRKEKEAVIEEELDEEDEKRR---MEVDKKIKDI 1803
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
5-598 2.38e-10

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 64.69  E-value: 2.38e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593     5 KKQDAEEQCllkKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHT 84
Cdd:TIGR02168  345 KLEELKEEL---ESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQ 421
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593    85 KLALAEARVQEEEQKATRLE-KELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEEL 163
Cdd:TIGR02168  422 EIEELLKKLEEAELKELQAElEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENL 501
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   164 QD---------------------IKEKIS-KGEYGNA------------------GIMAEVEELRK----RVL------- 192
Cdd:TIGR02168  502 EGfsegvkallknqsglsgilgvLSELISvDEGYEAAieaalggrlqavvvenlnAAKKAIAFLKQnelgRVTflpldsi 581
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   193 ---DMEGKDEELIKMEEQCRDLNKRLERetlQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQE----------------C 253
Cdd:TIGR02168  582 kgtEIQGNDREILKNIEGFLGVAKDLVK---FDPKLRKALSYLLGGVLVVDDLDNALELAKKLrpgyrivtldgdlvrpG 658
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   254 YSLKCNLEKERMTTKQLSQELESLKvriKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKlkktEDKLQAA 333
Cdd:TIGR02168  659 GVITGGSAKTNSSILERRREIEELE---EKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEEL----SRQISAL 731
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   334 SSQLQVEQNKVttvtEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKD 413
Cdd:TIGR02168  732 RKDLARLEAEV----EQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDE 807
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   414 FLK--NKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRyanerdkaqfLSKELEH 491
Cdd:TIGR02168  808 LRAelTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEE----------LESELEA 877
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   492 VKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDlicHLQGDHSVLQKKLNQQENRN-R 570
Cdd:TIGR02168  878 LLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLE---GLEVRIDNLQERLSEEYSLTlE 954
                          650       660
                   ....*....|....*....|....*...
gi 767925593   571 DLGREIENLTKELERYRHFSKSLRPSLN 598
Cdd:TIGR02168  955 EAEALENKIEDDEEEARRRLKRLENKIK 982
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
61-585 2.43e-10

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 64.70  E-value: 2.43e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593    61 LTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQ-------TTKFHQDQDTIM---AKLTNEDS 130
Cdd:TIGR02169  299 LEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEErkrrdklTEEYAELKEELEdlrAELEEVDK 378
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   131 QNR-------QLQQKLAALSRQIDELEETNRSL----RKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDE 199
Cdd:TIGR02169  379 EFAetrdelkDYREKLEKLKREINELKRELDRLqeelQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLE 458
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   200 ELIKMEEqcrDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELesLKV 279
Cdd:TIGR02169  459 QLAADLS---KYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRAVEEVLKASIQGVHGTVAQL--GSV 533
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   280 RIKELEAIES----RLE----KTEFTLKEDLTKLKT----------LTVMFVDERktMSEKLKKT------------EDK 329
Cdd:TIGR02169  534 GERYATAIEVaagnRLNnvvvEDDAVAKEAIELLKRrkagratflpLNKMRDERR--DLSILSEDgvigfavdlvefDPK 611
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   330 LQAASSQ-----LQVE----------QNKVTTVTEKLIEET----------KRALKSKTDVEEKMYSVTKERDDLKNKLK 384
Cdd:TIGR02169  612 YEPAFKYvfgdtLVVEdieaarrlmgKYRMVTLEGELFEKSgamtggsrapRGGILFSRSEPAELQRLRERLEGLKRELS 691
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   385 AEEEKGNDLLSRVNMLKNRL----QSLEAIEKDflKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKA---- 456
Cdd:TIGR02169  692 SLQSELRRIENRLDELSQELsdasRKIGEIEKE--IEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEAriee 769
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   457 IEDDLMKTEDEYETLERRYANERdkAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKE 536
Cdd:TIGR02169  770 LEEDLHKLEEALNDLEARLSHSR--IPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKE 847
                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*....
gi 767925593   537 KIHEYMATEDLichLQGDHSVLQKKLNQQENRNRDLGREIENLTKELER 585
Cdd:TIGR02169  848 QIKSIEKEIEN---LNGKKEELEEELEELEAALRDLESRLGDLKKERDE 893
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
36-589 4.89e-10

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 63.70  E-value: 4.89e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593    36 RVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEeeqKATRLEKELQTQTTKFH 115
Cdd:pfam12128  242 EFTKLQQEFNTLESAELRLSHLHFGYKSDETLIASRQEERQETSAELNQLLRTLDDQWKE---KRDELNGELSAADAAVA 318
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   116 QDQdtimAKLTNEDSQNRQLQQ----KLAALSRQID----ELEETNRSLRKAEEELQDIKEKIskgeygNAGIMAEVEEL 187
Cdd:pfam12128  319 KDR----SELEALEDQHGAFLDadieTAAADQEQLPswqsELENLEERLKALTGKHQDVTAKY------NRRRSKIKEQN 388
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   188 rkrVLDMEGKDEELIKMEEQcRDLNKRLERETLQSKDFKLEveklskrimalEKLEDAFNKSKQECYSLKCNLEKERMTT 267
Cdd:pfam12128  389 ---NRDIAGIKDKLAKIREA-RDRQLAVAEDDLQALESELR-----------EQLEAGKLEFNEEEYRLKSRLGELKLRL 453
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   268 KQL---SQELESLKVRIKELEAIESRLEKTeFTLKEDLTklktltvmfvDERKTMSEKLKKTEDKLQAASSQLQVEQNKV 344
Cdd:pfam12128  454 NQAtatPELLLQLENFDERIERAREEQEAA-NAEVERLQ----------SELRQARKRRDQASEALRQASRRLEERQSAL 522
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   345 TTVTEKLIEETKRAL----KSKTDVEEKMYSVTKE----RDDLKNKLKAEEEKGNDLLSRVNMlknRLQSLEAIEKDFLK 416
Cdd:pfam12128  523 DELELQLFPQAGTLLhflrKEAPDWEQSIGKVISPellhRTDLDPEVWDGSVGGELNLYGVKL---DLKRIDVPEWAASE 599
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   417 NKLNQDSGKSTTALHQENNKIKELSQ-------EVERLKLKLKDMKAI----EDDLMKTEDEYETLERR----YANERDK 481
Cdd:pfam12128  600 EELRERLDKAEEALQSAREKQAAAEEqlvqangELEKASREETFARTAlknaRLDLRRLFDEKQSEKDKknkaLAERKDS 679
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   482 AQFLSKELEHVKMELA---KYKLAEKTETSHE---QWLFKRLQEEEAKSGHLSReVDALKEKIHEYMATEDLICHLQGDH 555
Cdd:pfam12128  680 ANERLNSLEAQLKQLDkkhQAWLEEQKEQKREartEKQAYWQVVEGALDAQLAL-LKAAIAARRSGAKAELKALETWYKR 758
                          570       580       590
                   ....*....|....*....|....*....|....
gi 767925593   556 SVlqKKLNQQENRNRDLGREIENLTKELERYRHF 589
Cdd:pfam12128  759 DL--ASLGVDPDVIAKLKREIRTLERKIERIAVR 790
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
19-332 6.16e-10

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 63.54  E-value: 6.16e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593    19 IDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQ 98
Cdd:TIGR02168  710 LEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEA 789
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593    99 KATRLEKELQTQTTKF----------HQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKE 168
Cdd:TIGR02168  790 QIEQLKEELKALREALdelraeltllNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIE 869
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   169 KISKGEYGNAGIMAEVEELRKRV-LDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMAL-EKLEDAF 246
Cdd:TIGR02168  870 ELESELEALLNERASLEEALALLrSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLqERLSEEY 949
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   247 NKSKQECYSLKCNLEKERMttkQLSQELESLKVRIKEL--------EAIESRLEKTEF--TLKEDLTK-LKTLTVMFVDE 315
Cdd:TIGR02168  950 SLTLEEAEALENKIEDDEE---EARRRLKRLENKIKELgpvnlaaiEEYEELKERYDFltAQKEDLTEaKETLEEAIEEI 1026
                          330
                   ....*....|....*..
gi 767925593   316 RKTMSEKLKKTEDKLQA 332
Cdd:TIGR02168 1027 DREARERFKDTFDQVNE 1043
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
16-622 6.46e-10

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 63.21  E-value: 6.46e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593    16 KKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTA-------QLTLQRQKIQELTTNAKETHTKLAL 88
Cdd:pfam15921  337 KRMYEDKIEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLAdlhkrekELSLEKEQNKRLWDRDTGNSITIDH 416
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593    89 AEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNED-------SQNRQLQQKLAALSRQIDELEETNRSLRKAEE 161
Cdd:pfam15921  417 LRRELDDRNMEVQRLEALLKAMKSECQGQMERQMAAIQGKNeslekvsSLTAQLESTKEMLRKVVEELTAKKMTLESSER 496
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   162 ELQDIKEKISKGEYGNAGIMAEVEELRKRVlDMEGKDEELIKME-EQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALE 240
Cdd:pfam15921  497 TVSDLTASLQEKERAIEATNAEITKLRSRV-DLKLQELQHLKNEgDHLRNVQTECEALKLQMAEKDKVIEILRQQIENMT 575
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   241 KLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLK----VRIKELEAIESRLEKTEFTL----KEDLTKLKTLTvmf 312
Cdd:pfam15921  576 QLVGQHGRTAGAMQVEKAQLEKEINDRRLELQEFKILKdkkdAKIRELEARVSDLELEKVKLvnagSERLRAVKDIK--- 652
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   313 vDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLiEETKRALKSktdveeKMYSVTKERDDLKNKLKAEEEKGND 392
Cdd:pfam15921  653 -QERDQLLNEVKTSRNELNSLSEDYEVLKRNFRNKSEEM-ETTTNKLKM------QLKSAQSELEQTRNTLKSMEGSDGH 724
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   393 LLS--------------RVNMLKNRLQSLEAI------EKDFLKNKLNQDSGKSTTALHQENNKIKEL----SQEvERLK 448
Cdd:pfam15921  725 AMKvamgmqkqitakrgQIDALQSKIQFLEEAmtnankEKHFLKEEKNKLSQELSTVATEKNKMAGELevlrSQE-RRLK 803
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   449 LKLKDMKAIEDDLMKTEDEYETLERRYANE--RDKAQFL--SKELE---HVKMELAKYKLAEKTETSHEQWLFKRLQEEE 521
Cdd:pfam15921  804 EKVANMEVALDKASLQFAECQDIIQRQEQEsvRLKLQHTldVKELQgpgYTSNSSMKPRLLQPASFTRTHSNVPSSQSTA 883
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   522 AKSGHLSREVDALKEKiheymATEDLICHLQGDHSVLQKKLNQQENRNRDLGRE---------IENLTKELERYRHFSKS 592
Cdd:pfam15921  884 SFLSHHSRKTNALKED-----PTRDLKQLLQELRSVINEEPTVQLSKAEDKGRApslgalddrVRDCIIESSLRSDICHS 958
                          650       660       670
                   ....*....|....*....|....*....|.
gi 767925593   593 LRPSLNGRRISDPQVFSKE-VQTEAVDNEPP 622
Cdd:pfam15921  959 SSNSLQTEGSKSSETCSREpVLLHAGELEDP 989
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
137-548 1.20e-09

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 62.09  E-value: 1.20e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 137 QKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEygnagimAEVEELRKRVLDMEgKDEELIKMEEQCRDLNKRLE 216
Cdd:COG4717   71 KELKELEEELKEAEEKEEEYAELQEELEELEEELEELE-------AELEELREELEKLE-KLLQLLPLYQELEALEAELA 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 217 RETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNL-EKERMTTKQLSQELESLKVRIKELEAIESRLEKTE 295
Cdd:COG4717  143 ELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLsLATEEELQDLAEELEELQQRLAELEEELEEAQEEL 222
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 296 FTLKEDLTKLKTLTvmfvdERKTMSEKLKKTEDKLQAASSQLQVE------------------------------QNKVT 345
Cdd:COG4717  223 EELEEELEQLENEL-----EAAALEERLKEARLLLLIAAALLALLglggsllsliltiagvlflvlgllallfllLAREK 297
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 346 TVTEKLIEETkRALKSKTDVEEKMYSVTKERDDLKNKLKAEE--------EKGNDLLSRVNMLKNRLQ-SLEAIEKDFLK 416
Cdd:COG4717  298 ASLGKEAEEL-QALPALEELEEEELEELLAALGLPPDLSPEEllelldriEELQELLREAEELEEELQlEELEQEIAALL 376
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 417 NKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEyETLERRYANERDKAQFLSKELEHVKMEL 496
Cdd:COG4717  377 AEAGVEDEEELRAALEQAEEYQELKEELEELEEQLEELLGELEELLEALDE-EELEEELEELEEELEELEEELEELREEL 455
                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767925593 497 AKYKLA-EKTETSHEqwLFKRLQEEEaksgHLSREVDALKEKIHEYMATEDLI 548
Cdd:COG4717  456 AELEAElEQLEEDGE--LAELLQELE----ELKAELRELAEEWAALKLALELL 502
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
57-540 1.36e-09

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 61.98  E-value: 1.36e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  57 EQQRLTAQLTLQR------------QKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELqtqttkfhqdqDTIMAK 124
Cdd:PRK02224 233 RETRDEADEVLEEheerreeletleAEIEDLRETIAETEREREELAEEVRDLRERLEELEEER-----------DDLLAE 301
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 125 LTNEDSQNRQLQQKLAALSRQIDELEETnrslrkAEEELQDIKEKISkgeygnagimaEVEELRKRVLDMEGKDEELikm 204
Cdd:PRK02224 302 AGLDDADAEAVEARREELEDRDEELRDR------LEECRVAAQAHNE-----------EAESLREDADDLEERAEEL--- 361
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 205 EEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEK----LEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVR 280
Cdd:PRK02224 362 REEAAELESELEEAREAVEDRREEIEELEEEIEELRErfgdAPVDLGNAEDFLEELREERDELREREAELEATLRTARER 441
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 281 IKE----------------------LEAIESRLEKTEfTLKEDLTKLKTlTVMFVDERKTMSEKLKKTE-------DKLQ 331
Cdd:PRK02224 442 VEEaealleagkcpecgqpvegsphVETIEEDRERVE-ELEAELEDLEE-EVEEVEERLERAEDLVEAEdrierleERRE 519
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 332 AASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDdlknklKAEE--EKGNDLLSRVNMLKNRLQSLEA 409
Cdd:PRK02224 520 DLEELIAERRETIEEKRERAEELRERAAELEAEAEEKREAAAEAEE------EAEEarEEVAELNSKLAELKERIESLER 593
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 410 IEKDFlknklnqdsgksttalhqenNKIKELSQEVERLKLKLKDMKAIEDdlmkteDEYETLERRyaneRDKAQFLSKEL 489
Cdd:PRK02224 594 IRTLL--------------------AAIADAEDEIERLREKREALAELND------ERRERLAEK----RERKRELEAEF 643
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767925593 490 EHVKMELAKYKLaEKTETSHEQwLFKRLQEEEAKSGHLSREVDALKEKIHE 540
Cdd:PRK02224 644 DEARIEEAREDK-ERAEEYLEQ-VEEKLDELREERDDLQAEIGAVENELEE 692
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
55-500 1.88e-09

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 61.32  E-value: 1.88e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  55 VDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTkfhqdqdtimakltneDSQNRQ 134
Cdd:COG4717   73 LKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPL----------------YQELEA 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 135 LQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEygnagimAEVEELRKRVLdmEGKDEELIKMEEQCRDLNKR 214
Cdd:COG4717  137 LEAELAELPERLEELEERLEELRELEEELEELEAELAELQ-------EELEELLEQLS--LATEEELQDLAEELEELQQR 207
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 215 LERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQecyslkcnLEKERMTTKQLSqeleslkvRIKELEAIESRLEKT 294
Cdd:COG4717  208 LAELEEELEEAQEELEELEEELEQLENELEAAALEER--------LKEARLLLLIAA--------ALLALLGLGGSLLSL 271
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 295 EFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKL-----------------IEETKR 357
Cdd:COG4717  272 ILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALglppdlspeellelldrIEELQE 351
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 358 ALKSKTDVEEKMY--SVTKERDDLKNKLKAEEE-----------KGNDLLSRVNMLKNRLQSL----EAIEKDFLKNKLN 420
Cdd:COG4717  352 LLREAEELEEELQleELEQEIAALLAEAGVEDEeelraaleqaeEYQELKEELEELEEQLEELlgelEELLEALDEEELE 431
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 421 QDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAiEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYK 500
Cdd:COG4717  432 EELEELEEELEELEEELEELREELAELEAELEQLEE-DGELAELLQELEELKAELRELAEEWAALKLALELLEEAREEYR 510
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
226-490 4.19e-09

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 60.33  E-value: 4.19e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 226 KLEVEKLSKRIMALEKLEDAFNKSKQecYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKteftLKEDLTKL 305
Cdd:PRK05771  39 ELSNERLRKLRSLLTKLSEALDKLRS--YLPKLNPLREEKKKVSVKSLEELIKDVEEELEKIEKEIKE----LEEEISEL 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 306 KtltvmfvDERKTMSEKLKKTEdKLQAASSQLQVEQN-KVTTVTEKLIEETKralksktdveekmYSVTKERDDLKNKLK 384
Cdd:PRK05771 113 E-------NEIKELEQEIERLE-PWGNFDLDLSLLLGfKYVSVFVGTVPEDK-------------LEELKLESDVENVEY 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 385 AEEEKGNDLLSRVNmLKNRLQSLEAI--EKDFLKNKLNqDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLM 462
Cdd:PRK05771 172 ISTDKGYVYVVVVV-LKELSDEVEEElkKLGFERLELE-EEGTPSELIREIKEELEEIEKERESLLEELKELAKKYLEEL 249
                        250       260
                 ....*....|....*....|....*...
gi 767925593 463 KTEDEYetlerrYANERDKAQFLSKELE 490
Cdd:PRK05771 250 LALYEY------LEIELERAEALSKFLK 271
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
20-593 5.58e-09

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 60.19  E-value: 5.58e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593    20 DQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLtlqrQKIQELTTNAKETHTKLALA---------- 89
Cdd:pfam01576    4 EEEMQAKEEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQL----QAETELCAEAEEMRARLAARkqeleeilhe 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593    90 -EARVQEEEQKATrlekELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKE 168
Cdd:pfam01576   80 lESRLEEEEERSQ----QLQNEKKKMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLLEDQNSKLSKERK 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   169 KISKGEYGNAGIMAEVEELRKRVLDMEGKDEELI-------KMEEQCR----DLNKRLERETL----QSKDFKLEVEKLS 233
Cdd:pfam01576  156 LLEERISEFTSNLAEEEEKAKSLSKLKNKHEAMIsdleerlKKEEKGRqeleKAKRKLEGESTdlqeQIAELQAQIAELR 235
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   234 KRIMALEK-LEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLkvrikELE-AIESRLEKTEFTLKEDLTKLKTLTVM 311
Cdd:pfam01576  236 AQLAKKEEeLQAALARLEEETAQKNNALKKIRELEAQISELQEDL-----ESErAARNKAEKQRRDLGEELEALKTELED 310
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   312 FVD----------ERKTMSEKLKKT-EDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLK 380
Cdd:pfam01576  311 TLDttaaqqelrsKREQEVTELKKAlEEETRSHEAQLQEMRQKHTQALEELTEQLEQAKRNKANLEKAKQALESENAELQ 390
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   381 NKLKAEEEKGNDLLSRVNMLKNRLQSLEA--IEKDFLKNKLNQDSGKS-------TTALHQENNKIKELSQEVERLKLKL 451
Cdd:pfam01576  391 AELRTLQQAKQDSEHKRKKLEGQLQELQArlSESERQRAELAEKLSKLqselesvSSLLNEAEGKNIKLSKDVSSLESQL 470
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   452 KDMK-----------AIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELA--KYKLAEKTETSHeqwlfkrlQ 518
Cdd:pfam01576  471 QDTQellqeetrqklNLSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSdmKKKLEEDAGTLE--------A 542
                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767925593   519 EEEAKSgHLSREVDALKEKIHEYMATEDlichlqgdhsvlqkKLNQQENRnrdLGREIENLTKELERYRHFSKSL 593
Cdd:pfam01576  543 LEEGKK-RLQRELEALTQQLEEKAAAYD--------------KLEKTKNR---LQQELDDLLVDLDHQRQLVSNL 599
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
14-521 1.42e-08

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 58.90  E-value: 1.42e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593    14 LLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKL----KSFALMVVDEQQRLTAQLTLQRQKIQELTtNAKETHTKLALA 89
Cdd:TIGR00606  398 LVIERQEDEAKTAAQLCADLQSKERLKQEQADEIrdekKGLGRTIELKKEILEKKQEELKFVIKELQ-QLEGSSDRILEL 476
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593    90 EARVQEEEQKATRLEKELQTQTTKfhQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRK---AEEELQDI 166
Cdd:TIGR00606  477 DQELRKAERELSKAEKNSLTETLK--KEVKSLQNEKADLDRKLRKLDQEMEQLNHHTTTRTQMEMLTKDkmdKDEQIRKI 554
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   167 KEKISKGEYGNAGIMAEVEELRKRvldMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALE-KLEDA 245
Cdd:TIGR00606  555 KSRHSDELTSLLGYFPNKKQLEDW---LHSKSKEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEdKLFDV 631
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   246 FNKSKQECY--SLKCNLEKERMTTKQLSQELESLKVRIKELEAIES-------RLEKTEFTLKEDLTKLKTLTVMFVDER 316
Cdd:TIGR00606  632 CGSQDEESDleRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQsccpvcqRVFQTEAELQEFISDLQSKLRLAPDKL 711
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   317 KTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNkLKAEEEKGNDLLSR 396
Cdd:TIGR00606  712 KSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELRNKLQKVNRDIQRLKNDIEEQETLLGT-IMPEEESAKVCLTD 790
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   397 VNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKE-------LSQEVERLKLKLKDMKAIEDDLMKTEDEYE 469
Cdd:TIGR00606  791 VTIMERFQMELKDVERKIAQQAAKLQGSDLDRTVQQVNQEKQEkqheldtVVSKIELNRKLIQDQQEQIQHLKSKTNELK 870
                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 767925593   470 TLERRYANERDKAQFLSKELEHVKMELAK----YKLAEKTETSHEQWLFKRLQEEE 521
Cdd:TIGR00606  871 SEKLQIGTNLQRRQQFEEQLVELSTEVQSlireIKDAKEQDSPLETFLEKDQQEKE 926
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
9-490 1.58e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 58.79  E-value: 1.58e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   9 AEEQCLLKKLI--DQEIKSQEEKEQEKEKRVTTLKEELTKLKsfalmvvDEQQRLTAQLTLQRQKIQELTTNAKETHTKL 86
Cdd:COG1196  288 AEEYELLAELArlEQDIARLEERRRELEERLEELEEELAELE-------EELEELEEELEELEEELEEAEEELEEAEAEL 360
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  87 ALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDI 166
Cdd:COG1196  361 AEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEE 440
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 167 KEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAF 246
Cdd:COG1196  441 EEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLR 520
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 247 NKS------------------------------------KQECYSLKCN-------LEKERMTTKQLSQELESLKVRIKE 283
Cdd:COG1196  521 GLAgavavligveaayeaaleaalaaalqnivveddevaAAAIEYLKAAkagratfLPLDKIRARAALAAALARGAIGAA 600
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 284 LEAIESRLEKTE-------FTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETK 356
Cdd:COG1196  601 VDLVASDLREADaryyvlgDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAE 680
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 357 RALKSKTDVEEKMYSVTK--ERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLkNKLNQDSGKSTTALHQEN 434
Cdd:COG1196  681 LEELAERLAEEELELEEAllAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEEL-LEEEELLEEEALEELPEP 759
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767925593 435 NKIKELSQEVERLKLKLKDMKAIEddlMKTEDEYETLERRYanerdkaQFLSKELE 490
Cdd:COG1196  760 PDLEELERELERLEREIEALGPVN---LLAIEEYEELEERY-------DFLSEQRE 805
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
39-389 2.70e-08

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 58.06  E-value: 2.70e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593    39 TLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLE---KELQTQTTKFH 115
Cdd:pfam02463  663 EVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKKLKLEAEELLADRVQeaqDKINEELKLLK 742
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   116 QDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDEL-EETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDM 194
Cdd:pfam02463  743 QKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELaEEREKTEKLKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQL 822
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   195 EGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQEL 274
Cdd:pfam02463  823 LIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKEL 902
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   275 ESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEE 354
Cdd:pfam02463  903 EEESQKLNLLEEKENEIEERIKEEAEILLKYEEEPEELLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAIEE 982
                          330       340       350
                   ....*....|....*....|....*....|....*
gi 767925593   355 TKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEK 389
Cdd:pfam02463  983 FEEKEERYNKDELEKERLEEEKKKLIRAIIEETCQ 1017
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
142-469 2.81e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 58.02  E-value: 2.81e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 142 LSRQIDELE------ETNRSLrKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRL 215
Cdd:COG1196  198 LERQLEPLErqaekaERYREL-KEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLEL 276
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 216 ERETLQSKDFKLEVEKLSKRIMALEKledafnkskqecyslkcNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTE 295
Cdd:COG1196  277 EELELELEEAQAEEYELLAELARLEQ-----------------DIARLEERRRELEERLEELEEELAELEEELEELEEEL 339
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 296 FTLKEDLTKLKTltvmfvdERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMysvTKE 375
Cdd:COG1196  340 EELEEELEEAEE-------ELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELE---EAE 409
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 376 RDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLK-NKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDM 454
Cdd:COG1196  410 EALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEeAELEEEEEALLELLAELLEEAALLEAALAELLEELAEA 489
                        330
                 ....*....|....*
gi 767925593 455 KAIEDDLMKTEDEYE 469
Cdd:COG1196  490 AARLLLLLEAEADYE 504
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
21-495 4.65e-08

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 56.95  E-value: 4.65e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   21 QEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTL---QRQKIQELTTNAKETHTKLALAEARVQEEE 97
Cdd:TIGR04523 131 KQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLlekEKLNIQKNIDKIKNKLLKLELLLSNLKKKI 210
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   98 QKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGN 177
Cdd:TIGR04523 211 QKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKELEQNNKKIKELEKQL 290
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  178 AGIMAEVEELRKRVLDMEGKD--EELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIM------------------ 237
Cdd:TIGR04523 291 NQLKSEISDLNNQKEQDWNKElkSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTnsesensekqreleekqn 370
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  238 ALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERK 317
Cdd:TIGR04523 371 EIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDS 450
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  318 TMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLiEETKRALKSKTDveeKMYSVTKERDDLKNKLKAEEEKGNDLLSRV 397
Cdd:TIGR04523 451 VKELIIKNLDNTRESLETQLKVLSRSINKIKQNL-EQKQKELKSKEK---ELKKLNEEKKELEEKVKDLTKKISSLKEKI 526
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  398 NMLKNRL----QSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKlklKDMKAIEDDLMKTEDEYETLER 473
Cdd:TIGR04523 527 EKLESEKkekeSKISDLEDELNKDDFELKKENLEKEIDEKNKEIEELKQTQKSLK---KKQEEKQELIDQKEKEKKDLIK 603
                         490       500
                  ....*....|....*....|..
gi 767925593  474 RYANERDKAQFLSKELEHVKME 495
Cdd:TIGR04523 604 EIEEKEKKISSLEKELEKAKKE 625
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
9-584 5.74e-08

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 56.90  E-value: 5.74e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593     9 AEEQCLLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFAlmvVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLAL 88
Cdd:pfam02463  179 IEETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLEL---EEEYLLYLDYLKLNEERIDLLQELLRDEQEEIES 255
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593    89 AEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKE 168
Cdd:pfam02463  256 SKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKE 335
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   169 KIS--KGEYGNAGI-----MAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEK 241
Cdd:pfam02463  336 EIEelEKELKELEIkreaeEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELAR 415
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   242 LEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFV-------- 313
Cdd:pfam02463  416 QLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLElllsrqkl 495
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   314 DERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDL 393
Cdd:pfam02463  496 EERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAVIVEVSATADEVEERQKLVRALTELPL 575
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   394 LSRVNMLKNRLQSLEA------------IEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKL----KDMKAI 457
Cdd:pfam02463  576 GARKLRLLIPKLKLPLksiavleidpilNLAQLDKATLEADEDDKRAKVVEGILKDTELTKLKESAKAKEsglrKGVSLE 655
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   458 EDDLMKTEDEYETLE--RRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVD--- 532
Cdd:pfam02463  656 EGLAEKSEVKASLSEltKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKKLKLEAEELLADRVQEAQDkin 735
                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 767925593   533 ----ALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELE 584
Cdd:pfam02463  736 eelkLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEE 791
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
40-245 1.17e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 55.16  E-value: 1.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  40 LKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKF----- 114
Cdd:COG4942   32 LQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEELaellr 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 115 ----HQDQDTIMAKLTNEDSQnrQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKR 190
Cdd:COG4942  112 alyrLGRQPPLALLLSPEDFL--DAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAELEEERAA 189
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767925593 191 VLDMEGKDEELIKmeeqcrDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDA 245
Cdd:COG4942  190 LEALKAERQKLLA------RLEKELAELAAELAELQQEAEELEALIARLEAEAAA 238
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
41-421 1.20e-07

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 55.80  E-value: 1.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   41 KEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLAlaearvQEEEQKATRLEKELQTQTTKFHQDQDT 120
Cdd:TIGR04523 252 QTQLNQLKDEQNKIKKQLSEKQKELEQNNKKIKELEKQLNQLKSEIS------DLNNQKEQDWNKELKSELKNQEKKLEE 325
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  121 IMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKgeyGNAGIMAEVEELRKRVLDMEGK--- 197
Cdd:TIGR04523 326 IQNQISQNNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKK---ENQSYKQEIKNLESQINDLESKiqn 402
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  198 --------DEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQ-----------ECYSLKC 258
Cdd:TIGR04523 403 qeklnqqkDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTREsletqlkvlsrSINKIKQ 482
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  259 NLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQaaSSQLQ 338
Cdd:TIGR04523 483 NLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEDELNKDDFELK--KENLE 560
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  339 VEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEK--DFLK 416
Cdd:TIGR04523 561 KEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKniKSKK 640

                  ....*
gi 767925593  417 NKLNQ 421
Cdd:TIGR04523 641 NKLKQ 645
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
38-620 1.32e-07

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 55.75  E-value: 1.32e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593    38 TTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQElttnakethtklalaEARVQEEEQKATRLEKELQTQTTKFHQD 117
Cdd:TIGR00618  218 HERKQVLEKELKHLREALQQTQQSHAYLTQKREAQEE---------------QLKKQQLLKQLRARIEELRAQEAVLEET 282
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   118 QDTI-----MAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVL 192
Cdd:TIGR00618  283 QERInrarkAAPLAAHIKAVTQIEQQAQRIHTELQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHE 362
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   193 DMEGKDEELIK---MEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLK--CNLEKERMTT 267
Cdd:TIGR00618  363 VATSIREISCQqhtLTQHIHTLQQQKTTLTQKLQSLCKELDILQREQATIDTRTSAFRDLQGQLAHAKkqQELQQRYAEL 442
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   268 KQL--SQELESLKVRIKELEAIESRLEKTEFTLK------EDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLqV 339
Cdd:TIGR00618  443 CAAaiTCTAQCEKLEKIHLQESAQSLKEREQQLQtkeqihLQETRKKAVVLARLLELQEEPCPLCGSCIHPNPARQDI-D 521
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   340 EQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKL 419
Cdd:TIGR00618  522 NPGPLTRRMQRGEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQDLTE 601
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   420 NQDSGKSTTALHQENNKIK------------ELSQEVERLKLKLKDMKAIEDDLMK----------TEDEYETLERRyAN 477
Cdd:TIGR00618  602 KLSEAEDMLACEQHALLRKlqpeqdlqdvrlHLQQCSQELALKLTALHALQLTLTQervrehalsiRVLPKELLASR-QL 680
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   478 ERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSG----HLSREVDALKEKIHEYMATED-LICHLQ 552
Cdd:TIGR00618  681 ALQKMQSEKEQLTYWKEMLAQCQTLLRELETHIEEYDREFNEIENASSslgsDLAAREDALNQSLKELMHQARtVLKART 760
                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767925593   553 GDHSVLQKKLNQQENRN---RDLGREIENLTKELERYRHFSKSLRPSLNGRRISDPQVFSKEVQTEAVDNE 620
Cdd:TIGR00618  761 EAHFNNNEEVTAALQTGaelSHLAAEIQFFNRLREEDTHLLKTLEAEIGQEIPSDEDILNLQCETLVQEEE 831
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
6-610 1.50e-07

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 55.41  E-value: 1.50e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593    6 KQDAEEQCLLKKLI---------DQEIKSQEEKEQEKEKRVTTLKEELTKLKSfalmvvdEQQRLTAQLTLQRQKIQELT 76
Cdd:TIGR04523  30 KQDTEEKQLEKKLKtiknelknkEKELKNLDKNLNKDEEKINNSNNKIKILEQ-------QIKDLNDKLKKNKDKINKLN 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   77 TNAKETHTKLALAEARVQEEEQKATRLEKELQ----------TQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQI 146
Cdd:TIGR04523 103 SDLSKINSEIKNDKEQKNKLEVELNKLEKQKKenkknidkflTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEK 182
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  147 DELEE----TNRSLRKAEEELQDIKEKISKgeygNAGIMAEVEELRKRVL-----------DMEGKDEELIKMEEQCRDL 211
Cdd:TIGR04523 183 LNIQKnidkIKNKLLKLELLLSNLKKKIQK----NKSLESQISELKKQNNqlkdniekkqqEINEKTTEISNTQTQLNQL 258
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  212 NKRLERETLQSKDFKLEVEKLSKRImalEKLEDAFNKSKQECYSLkcNLEKERMTTKQLSQELESLKVRIKELEAIESRL 291
Cdd:TIGR04523 259 KDEQNKIKKQLSEKQKELEQNNKKI---KELEKQLNQLKSEISDL--NNQKEQDWNKELKSELKNQEKKLEEIQNQISQN 333
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  292 EKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQ-----------------AASSQLQVEQNKVTTVTEKLIEE 354
Cdd:TIGR04523 334 NKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEklkkenqsykqeiknleSQINDLESKIQNQEKLNQQKDEQ 413
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  355 TKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLK--NKLNQDSGKSTTALHQ 432
Cdd:TIGR04523 414 IKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRsiNKIKQNLEQKQKELKS 493
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  433 ENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKaqfLSKELEHVKMELAKYKLAEK-------- 504
Cdd:TIGR04523 494 KEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISD---LEDELNKDDFELKKENLEKEideknkei 570
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  505 TETSHEQWLFKRLQEE-EAKSGHLSREVDALKEKIHEYMATEdlichlqgdhSVLQKKLNQQENRNRDLGREIENLTKEL 583
Cdd:TIGR04523 571 EELKQTQKSLKKKQEEkQELIDQKEKEKKDLIKEIEEKEKKI----------SSLEKELEKAKKENEKLSSIIKNIKSKK 640
                         650       660
                  ....*....|....*....|....*..
gi 767925593  584 ERYRHFSKSLRPSLNGRRISDPQVFSK 610
Cdd:TIGR04523 641 NKLKQEVKQIKETIKEIRNKWPEIIKK 667
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
58-583 1.87e-07

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 55.11  E-value: 1.87e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   58 QQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQ 137
Cdd:pfam05483 228 EEEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKANQLEEKTKLQDENLKELIEKKDHLTKELEDIKMSLQR 307
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  138 KLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVldmegkdEELIKMEEQcrdlnkRLER 217
Cdd:pfam05483 308 SMSTQKALEEDLQIATKTICQLTEEKEAQMEELNKAKAAHSFVVTEFEATTCSL-------EELLRTEQQ------RLEK 374
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  218 ETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFT 297
Cdd:pfam05483 375 NEDQLKIITMELQKKSSELEEMTKFKNNKEVELEELKKILAEDEKLLDEKKQFEKIAEELKGKEQELIFLLQAREKEIHD 454
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  298 LKEDLTKLKTLTVMFVDERKTM-----SEKLKKTEdkLQAASSQLQVEQNKVTTVTEKLIEETK--------------RA 358
Cdd:pfam05483 455 LEIQLTAIKTSEEHYLKEVEDLkteleKEKLKNIE--LTAHCDKLLLENKELTQEASDMTLELKkhqediinckkqeeRM 532
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  359 LKSKTDVEEK-------MYSVTKE----RDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDsgKST 427
Cdd:pfam05483 533 LKQIENLEEKemnlrdeLESVREEfiqkGDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKCNNLKKQIENKN--KNI 610
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  428 TALHQENNKIKELSQEverlklKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQflsKELEHVKmeLAKYKLAEKTET 507
Cdd:pfam05483 611 EELHQENKALKKKGSA------ENKQLNAYEIKVNKLELELASAKQKFEEIIDNYQ---KEIEDKK--ISEEKLLEEVEK 679
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767925593  508 SH--EQWLFKRLQEEEAKSGHLSREVDALKEK-IHEYmatEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKEL 583
Cdd:pfam05483 680 AKaiADEAVKLQKEIDKRCQHKIAEMVALMEKhKHQY---DKIIEERDSELGLYKNKEQEQSSAKAALEIELSNIKAEL 755
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
57-609 2.09e-07

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 54.75  E-value: 2.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   57 EQQRLTAQLT-LQRQKIQ----------ELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKL 125
Cdd:pfam05557   3 ELIESKARLSqLQNEKKQmelehkrariELEKKASALKRQLDRESDRNQELQKRIRLLEKREAEAEEALREQAELNRLKK 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  126 TNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKME 205
Cdd:pfam05557  83 KYLEALNKKLNEKESQLADAREVISCLKNELSELRRQIQRAELELQSTNSELEELQERLDLLKAKASEAEQLRQNLEKQQ 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  206 EQCRDLNKR---LERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMttkqLSQELESLKVRIK 282
Cdd:pfam05557 163 SSLAEAEQRikeLEFEIQSQEQDSEIVKNSKSELARIPELEKELERLREHNKHLNENIENKLL----LKEEVEDLKRKLE 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  283 ELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMseklkKTEDKLQAASSQLQveQNKVTTVTEK--LIEETKRALK 360
Cdd:pfam05557 239 REEKYREEAATLELEKEKLEQELQSWVKLAQDTGLNL-----RSPEDLSRRIEQLQ--QREIVLKEENssLTSSARQLEK 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  361 SKTDVEEKMYSVTKERDDLKNKLKAEEEkgndllsrvnmLKNRLQ---SLEAIEKDFLKNKL-NQDSGKSTT-ALHQENN 435
Cdd:pfam05557 312 ARRELEQELAQYLKKIEDLNKKLKRHKA-----------LVRRLQrrvLLLTKERDGYRAILeSYDKELTMSnYSPQLLE 380
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  436 KIKELSQEVERLKLKLKDMKAieddlmktedEYETLERRYANERDKAQFLSKELEhvkmelakyklaektetsheqwlFK 515
Cdd:pfam05557 381 RIEEAEDMTQKMQAHNEEMEA----------QLSVAEEELGGYKQQAQTLERELQ-----------------------AL 427
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  516 RLQEEEAKSGHLSREVDALKEKIHEYMAT-----------EDLICH--LQGD-----HSVLQKKLNQQENRNRDLGREIE 577
Cdd:pfam05557 428 RQQESLADPSYSKEEVDSLRRKLETLELErqrlreqknelEMELERrcLQGDydpkkTKVLHLSMNPAAEAYQQRKNQLE 507
                         570       580       590
                  ....*....|....*....|....*....|..
gi 767925593  578 NLTKELERYRHFSKSLRPSLNGRRISDPQVFS 609
Cdd:pfam05557 508 KLQAEIERLKRLLKKLEDDLEQVLRLPETTST 539
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
357-585 4.49e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 54.17  E-value: 4.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 357 RALKSKTDVEEKMYSVtKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAiEKDFLKNKLNQDSGKSTTALHQENNK 436
Cdd:COG1196  216 RELKEELKELEAELLL-LKLRELEAELEELEAELEELEAELEELEAELAELEA-ELEELRLELEELELELEEAQAEEYEL 293
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 437 IKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETsheqwlfKR 516
Cdd:COG1196  294 LAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAE-------EA 366
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767925593 517 LQEEEAKSGHLSREVDALKEKIHEymatedlichLQGDHSVLQKKLNQQENRNRDLGREIENLTKELER 585
Cdd:COG1196  367 LLEAEAELAEAEEELEELAEELLE----------ALRAAAELAAQLEELEEAEEALLERLERLEEELEE 425
COG5022 COG5022
Myosin heavy chain [General function prediction only];
130-649 4.72e-07

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 53.93  E-value: 4.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  130 SQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGnagimaEVEELRKRVLDMEgKDEELIKMEEQCR 209
Cdd:COG5022   806 LGSRKEYRSYLACIIKLQKTIKREKKLRETEEVEFSLKAEVLIQKFG------RSLKAKKRFSLLK-KETIYLQSAQRVE 878
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  210 DLNKRLERETLQSKdfklEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTT-----------KQLSQELESLK 278
Cdd:COG5022   879 LAERQLQELKIDVK----SISSLKLVNLELESEIIELKKSLSSDLIENLEFKTELIARlkkllnnidleEGPSIEYVKLP 954
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  279 VRIKELEAiESRLEKTEFTLkEDLTKLKTLTVmfvDERKTMSEKLKKTEDKLQAASSQLQVEQNKVttvteKLIEETKRA 358
Cdd:COG5022   955 ELNKLHEV-ESKLKETSEEY-EDLLKKSTILV---REGNKANSELKNFKKELAELSKQYGALQEST-----KQLKELPVE 1024
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  359 LKSKTDVEEKMYSVTKErddLKNKLKAEEEKGNDLLSrVNMLKNRLQSLEaIEKDFLKNKLNQDSGKSTTalhqeNNKIK 438
Cdd:COG5022  1025 VAELQSASKIISSESTE---LSILKPLQKLKGLLLLE-NNQLQARYKALK-LRRENSLLDDKQLYQLEST-----ENLLK 1094
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  439 ElsqeverlkLKLKDMKAIEDDLMKTEDEYETL---ERRYANERDKAQFLSKELEHVKMELAKYKLAEKT---------- 505
Cdd:COG5022  1095 T---------INVKDLEVTNRNLVKPANVLQFIvaqMIKLNLLQEISKFLSQLVNTLEPVFQKLSVLQLEldglfweanl 1165
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  506 -ETSHEQWlFKRLQEEEAKSGH---------------LSREVDALKEKIHEYMATEDLICHL--QGDHSVLQKKLNQQEN 567
Cdd:COG5022  1166 eALPSPPP-FAALSEKRLYQSAlydeksklsssevndLKNELIALFSKIFSGWPRGDKLKKLisEGWVPTEYSTSLKGFN 1244
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  568 RNRDLGREIENLTKelERYRHFSKSLRPSLNGRRISdPQVFSKEVQTEAVDNEPPDYKSLIPLERAVINGQLYEESENQD 647
Cdd:COG5022  1245 NLNKKFDTPASMSN--EKLLSLLNSIDNLLSSYKLE-EEVLPATINSLLQYINVGLFNALRTKASSLRWKSATEVNYNSE 1321

                  ..
gi 767925593  648 ED 649
Cdd:COG5022  1322 EL 1323
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
63-631 6.91e-07

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 53.43  E-value: 6.91e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593    63 AQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAAL 142
Cdd:TIGR00618  166 KELLMNLFPLDQYTQLALMEFAKKKSLHGKAELLTLRSQLLTLCTPCMPDTYHERKQVLEKELKHLREALQQTQQSHAYL 245
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   143 SRQIDELEETNRSLRKAEEELQDIKEKISKgeygnagiMAEVEELRKRvLDMEGKDEELIKMEEQCRDLNKRLER--ETL 220
Cdd:TIGR00618  246 TQKREAQEEQLKKQQLLKQLRARIEELRAQ--------EAVLEETQER-INRARKAAPLAAHIKAVTQIEQQAQRihTEL 316
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   221 QSKDFKLEVE-----KLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKvRIKELEAIESRLEKTE 295
Cdd:TIGR00618  317 QSKMRSRAKLlmkraAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREISCQQHTLTQ-HIHTLQQQKTTLTQKL 395
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   296 FTLKEDLTKLKTL--TVMFVDERKtmseklKKTEDKLQAASSQLQVEQnKVTTVTEKLIEETKRALKSKTDVEEKMYSVT 373
Cdd:TIGR00618  396 QSLCKELDILQREqaTIDTRTSAF------RDLQGQLAHAKKQQELQQ-RYAELCAAAITCTAQCEKLEKIHLQESAQSL 468
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   374 KERD----DLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEaiekdflknklnqdsgKSTTALHQENNKIKELSQEVERLKL 449
Cdd:TIGR00618  469 KEREqqlqTKEQIHLQETRKKAVVLARLLELQEEPCPLC----------------GSCIHPNPARQDIDNPGPLTRRMQR 532
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   450 KLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSR 529
Cdd:TIGR00618  533 GEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEAEDMLAC 612
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   530 EVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQqenrnrdLGREIENLTKELERYRHFSKSLRPSLNG-RRISDPQVF 608
Cdd:TIGR00618  613 EQHALLRKLQPEQDLQDVRLHLQQCSQELALKLTA-------LHALQLTLTQERVREHALSIRVLPKELLaSRQLALQKM 685
                          570       580
                   ....*....|....*....|...
gi 767925593   609 SKEVQTEAVDNEPPDYKSLIPLE 631
Cdd:TIGR00618  686 QSEKEQLTYWKEMLAQCQTLLRE 708
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
69-217 7.79e-07

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 53.38  E-value: 7.79e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   69 RQKIQELTTnakethtKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDtiMAKLTNEDSQNRQLQQKLAALSRQIDE 148
Cdd:COG4913   609 RAKLAALEA-------ELAELEEELAEAEERLEALEAELDALQERREALQR--LAEYSWDEIDVASAEREIAELEAELER 679
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767925593  149 LEETNRSLRKAEEELQDIKEKISKGEygnagimaevEELRKRVLDMEGKDEELIKMEEQCRDLNKRLER 217
Cdd:COG4913   680 LDASSDDLAALEEQLEELEAELEELE----------EELDELKGEIGRLEKELEQAEEELDELQDRLEA 738
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
86-358 7.82e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 52.46  E-value: 7.82e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  86 LALAEARVQEEEQKAtrLEKELQtqttKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEetnRSLRKAEEELQD 165
Cdd:COG4942   10 LLALAAAAQADAAAE--AEAELE----QLQQEIAELEKELAALKKEEKALLKQLAALERRIAALA---RRIRALEQELAA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 166 IKEKISKGEygnagimAEVEELRKRvldmegKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDA 245
Cdd:COG4942   81 LEAELAELE-------KEIAELRAE------LEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPA 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 246 fnkskqecyslkcnlEKERMttKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLtvmfVDERKTMSEKLKK 325
Cdd:COG4942  148 ---------------RREQA--EELRADLAELAALRAELEAERAELEALLAELEEERAALEAL----KAERQKLLARLEK 206
                        250       260       270
                 ....*....|....*....|....*....|...
gi 767925593 326 TEDKLQAASSQLQVEQNKVTTVTEKLIEETKRA 358
Cdd:COG4942  207 ELAELAAELAELQQEAEELEALIARLEAEAAAA 239
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
85-589 1.13e-06

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 52.53  E-value: 1.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  85 KLALAEARVQEEEQKATRLEKELQTQTT--KFHQDQDTIMAKltnedsqnrqlqqKLAALSRQIDELEETNRSLR--KAE 160
Cdd:PRK04778  38 KQELENLPVNDELEKVKKLNLTGQSEEKfeEWRQKWDEIVTN-------------SLPDIEEQLFEAEELNDKFRfrKAK 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 161 EELQDIKEKISKGEygnagimAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLeRETLQSKDFKL--EVEKLSKRima 238
Cdd:PRK04778 105 HEINEIESLLDLIE-------EDIEQILEELQELLESEEKNREEVEQLKDLYREL-RKSLLANRFSFgpALDELEKQ--- 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 239 LEKLEDAFNKSKQEcySLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTeftLKEDLTKLKT----------- 307
Cdd:PRK04778 174 LENLEEEFSQFVEL--TESGDYVEAREILDQLEEELAALEQIMEEIPELLKELQTE---LPDQLQELKAgyrelveegyh 248
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 308 LTVMFVDER-KTMSEKLKKTEDKLqaasSQLQVEqnkvttVTEKLIEETKRALKSKTDVEEKMY----SVTKERDDLKNK 382
Cdd:PRK04778 249 LDHLDIEKEiQDLKEQIDENLALL----EELDLD------EAEEKNEEIQERIDQLYDILEREVkarkYVEKNSDTLPDF 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 383 LKAEEEKGNDL-----------------LSRVNMLKNRLQSleaIEKDFLKNKLNQDSGKSTtalhqennkikeLSQEVE 445
Cdd:PRK04778 319 LEHAKEQNKELkeeidrvkqsytlneseLESVRQLEKQLES---LEKQYDEITERIAEQEIA------------YSELQE 383
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 446 RLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKL--------AEKTETSHE-QWLFKR 516
Cdd:PRK04778 384 ELEEILKQLEEIEKEQEKLSEMLQGLRKDELEAREKLERYRNKLHEIKRYLEKSNLpglpedylEMFFEVSDEiEALAEE 463
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767925593 517 LQEEEAKSGHLSREVDALKEKIHE-YMATEDLIchlqgDHSVLQKKLNQQENRNRDLGREIEN-LTKELERYRHF 589
Cdd:PRK04778 464 LEEKPINMEAVNRLLEEATEDVETlEEETEELV-----ENATLTEQLIQYANRYRSDNEEVAEaLNEAERLFREY 533
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
259-598 1.17e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 52.75  E-value: 1.17e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   259 NLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFtLKEDLTKL-KTLTVMFVDERKtmsEKLKKTEDKLQAASSQL 337
Cdd:TIGR02168  180 KLERTRENLDRLEDILNELERQLKSLERQAEKAERYKE-LKAELRELeLALLVLRLEELR---EELEELQEELKEAEEEL 255
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   338 QVEQNKVTTVTEKLieETKRALKSKtdVEEKMYSVTKERDDLKNKLkaeeekgNDLLSRVNMLKNRLQSLEaiekdflkN 417
Cdd:TIGR02168  256 EELTAELQELEEKL--EELRLEVSE--LEEEIEELQKELYALANEI-------SRLEQQKQILRERLANLE--------R 316
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   418 KLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANerdkaqfLSKELEHVKMELA 497
Cdd:TIGR02168  317 QLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEE-------LEEQLETLRSKVA 389
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   498 KYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEdlichLQGDHSVLQKKLNQQENRNRDLGREIE 577
Cdd:TIGR02168  390 QLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKE-----LQAELEELEEELEELQEELERLEEALE 464
                          330       340
                   ....*....|....*....|.
gi 767925593   578 NLTKELERYRHFSKSLRPSLN 598
Cdd:TIGR02168  465 ELREELEEAEQALDAAERELA 485
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
58-494 1.24e-06

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 52.44  E-value: 1.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   58 QQRLTAQLTLQRQKIQELTTNAKETHTKlalaEARVQEEEQKATRLEKELQTQTTKFHQDQdtimAKLTNEDSQNRQLQQ 137
Cdd:pfam05557  68 EEALREQAELNRLKKKYLEALNKKLNEK----ESQLADAREVISCLKNELSELRRQIQRAE----LELQSTNSELEELQE 139
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  138 KLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNA----------------GIMAEVEELRKRVLDMEGKDEEL 201
Cdd:pfam05557 140 RLDLLKAKASEAEQLRQNLEKQQSSLAEAEQRIKELEFEIQsqeqdseivknskselARIPELEKELERLREHNKHLNEN 219
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  202 IK----MEEQCRDLNKRLER-ETLQSKDFKLEVEK--------------------------LSKRIMALEKLEDAFnksK 250
Cdd:pfam05557 220 IEnkllLKEEVEDLKRKLEReEKYREEAATLELEKekleqelqswvklaqdtglnlrspedLSRRIEQLQQREIVL---K 296
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  251 QECYSLKCNLEKERMTTKQLSQE-------LESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKT----- 318
Cdd:pfam05557 297 EENSSLTSSARQLEKARRELEQElaqylkkIEDLNKKLKRHKALVRRLQRRVLLLTKERDGYRAILESYDKELTMsnysp 376
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  319 -MSEKLKKTEDKLQ-----AASSQLQVEQNKVTTVTEKLIEETK----RALKSKTDVEEKMYSvTKERDDLKNKLKAEEE 388
Cdd:pfam05557 377 qLLERIEEAEDMTQkmqahNEEMEAQLSVAEEELGGYKQQAQTLerelQALRQQESLADPSYS-KEEVDSLRRKLETLEL 455
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  389 KGNDLLSRVNMLKNRLQSLEaIEKDFLKNK---LNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTE 465
Cdd:pfam05557 456 ERQRLREQKNELEMELERRC-LQGDYDPKKtkvLHLSMNPAAEAYQQRKNQLEKLQAEIERLKRLLKKLEDDLEQVLRLP 534
                         490       500
                  ....*....|....*....|....*....
gi 767925593  466 DEYETLERRYANERdKAQFLSKELEHVKM 494
Cdd:pfam05557 535 ETTSTMNFKEVLDL-RKELESAELKNQRL 562
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
160-585 1.64e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 52.08  E-value: 1.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 160 EEELQDIKEKISKGEYGNAGI-MAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMA 238
Cdd:COG4717   48 LERLEKEADELFKPQGRKPELnLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQL 127
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 239 LEKLEDafnkskqecyslkcnLEKERMTTKQLSQELESLKVRIKELEAIESRLEKteftLKEDLTKLKT-LTVMFVDERK 317
Cdd:COG4717  128 LPLYQE---------------LEALEAELAELPERLEELEERLEELRELEEELEE----LEAELAELQEeLEELLEQLSL 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 318 TMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLiEETKRALKSktdveekmYSVTKERDDLKNKLKAEEE--------- 388
Cdd:COG4717  189 ATEEELQDLAEELEELQQRLAELEEELEEAQEEL-EELEEELEQ--------LENELEAAALEERLKEARLllliaaall 259
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 389 ----KGNDLLSRVNMLKNRLQSLEAI------EKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIE 458
Cdd:COG4717  260 allgLGGSLLSLILTIAGVLFLVLGLlallflLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEEL 339
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 459 DDLMKTEDEYETLERRYANERDKAQFlsKELEHVKMELAKYKLAEkTETSHEQWL--FKRLQEEEAKSGHLSREVDALKE 536
Cdd:COG4717  340 LELLDRIEELQELLREAEELEEELQL--EELEQEIAALLAEAGVE-DEEELRAALeqAEEYQELKEELEELEEQLEELLG 416
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*....
gi 767925593 537 KIHEYMATEDLIcHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELER 585
Cdd:COG4717  417 ELEELLEALDEE-ELEEELEELEEELEELEEELEELREELAELEAELEQ 464
PRK01156 PRK01156
chromosome segregation protein; Provisional
54-604 1.85e-06

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 51.83  E-value: 1.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  54 VVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNR 133
Cdd:PRK01156 174 VIDMLRAEISNIDYLEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYNNLKSALNELSSLEDMKNR 253
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 134 qLQQKLAALSRQIDELEETNRSLRKAEEELQDIkekISKGEYGNAGIMAEVEELRKRVLD----MEGKDEELIKMEEQCR 209
Cdd:PRK01156 254 -YESEIKTAESDLSMELEKNNYYKELEERHMKI---INDPVYKNRNYINDYFKYKNDIENkkqiLSNIDAEINKYHAIIK 329
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 210 DLNKrLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQEL-ESLKVRIKELEAIE 288
Cdd:PRK01156 330 KLSV-LQKDYNDYIKKKSRYDDLNNQILELEGYEMDYNSYLKSIESLKKKIEEYSKNIERMSAFIsEILKIQEIDPDAIK 408
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 289 SRLEKTEFTLKEDLTKLKTLTVmfvdERKTMSEKLKKTEDKLQAASSQlqveqNKVTTVTEKLIEETKRALKSktDVEEK 368
Cdd:PRK01156 409 KELNEINVKLQDISSKVSSLNQ----RIRALRENLDELSRNMEMLNGQ-----SVCPVCGTTLGEEKSNHIIN--HYNEK 477
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 369 MYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLK-----------NRLQSLEAIEKDFlKNKLNQDSGKSTTAlHQENNKI 437
Cdd:PRK01156 478 KSRLEEKIREIEIEVKDIDEKIVDLKKRKEYLEseeinksineyNKIESARADLEDI-KIKINELKDKHDKY-EEIKNRY 555
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 438 KELSQEVERLKLK--LKDMKAIED-DLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLF 514
Cdd:PRK01156 556 KSLKLEDLDSKRTswLNALAVISLiDIETNRSRSNEIKKQLNDLESRLQEIEIGFPDDKSYIDKSIREIENEANNLNNKY 635
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 515 KRLQEeeaksghLSREVDALKEKIHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLR 594
Cdd:PRK01156 636 NEIQE-------NKILIEKLRGKIDNYKKQIAEIDSIIPDLKEITSRINDIEDNLKKSRKALDDAKANRARLESTIEILR 708
                        570
                 ....*....|..
gi 767925593 595 PSLN--GRRISD 604
Cdd:PRK01156 709 TRINelSDRIND 720
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
9-418 1.87e-06

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 51.99  E-value: 1.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   9 AEEQCLLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKsfalmvvDEQQRLTAQLTLQRQKIQELttnaKETHTKLAL 88
Cdd:PRK03918 372 EELERLKKRLTGLTPEKLEKELEELEKAKEEIEEEISKIT-------ARIGELKKEIKELKKAIEEL----KKAKGKCPV 440
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  89 AEARVQEEEqkatrlEKELqtqTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDElEETNRSLRKAEEELQDIKE 168
Cdd:PRK03918 441 CGRELTEEH------RKEL---LEEYTAELKRIEKELKEIEEKERKLRKELRELEKVLKK-ESELIKLKELAEQLKELEE 510
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 169 KISKgeygnagimAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLEREtlqsKDFKLEVEKLSKRIMALE-KLEDAFN 247
Cdd:PRK03918 511 KLKK---------YNLEELEKKAEEYEKLKEKLIKLKGEIKSLKKELEKL----EELKKKLAELEKKLDELEeELAELLK 577
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 248 KSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLktltvmfvDERKTMSEKLKKTE 327
Cdd:PRK03918 578 ELEELGFESVEELEERLKELEPFYNEYLELKDAEKELEREEKELKKLEEELDKAFEEL--------AETEKRLEELRKEL 649
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 328 DKLQAASSqlQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKgndlLSRVNMLKNRLQSL 407
Cdd:PRK03918 650 EELEKKYS--EEEYEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEEREKA----KKELEKLEKALERV 723
                        410
                 ....*....|.
gi 767925593 408 EAIEKDFLKNK 418
Cdd:PRK03918 724 EELREKVKKYK 734
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
21-389 2.33e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 51.31  E-value: 2.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  21 QEIKSQEEKEQEKEKRVTTLKEELTKLKSF--ALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQ 98
Cdd:COG4717   95 EELEELEEELEELEAELEELREELEKLEKLlqLLPLYQELEALEAELAELPERLEELEERLEELRELEEELEELEAELAE 174
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  99 KATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEEtNRSLRKAEEELQDIKEKISKGEYG-- 176
Cdd:COG4717  175 LQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEE-ELEQLENELEAAALEERLKEARLLll 253
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 177 ----------------------------NAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFK-- 226
Cdd:COG4717  254 iaaallallglggsllsliltiagvlflVLGLLALLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPpd 333
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 227 LEVEKLSKRIMALEKLEDAFNKSKQecyslkcnlEKERMTTKQLSQELESL--KVRIKELEAIESRLEKTEfTLKEDLTK 304
Cdd:COG4717  334 LSPEELLELLDRIEELQELLREAEE---------LEEELQLEELEQEIAALlaEAGVEDEEELRAALEQAE-EYQELKEE 403
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 305 LKTLTVMFVDERKTMSEKLKKT-----EDKLQAASSQLQVEQNKVTTVTEKL--IEETKRALKSKTDVEEKMYsvtkERD 377
Cdd:COG4717  404 LEELEEQLEELLGELEELLEALdeeelEEELEELEEELEELEEELEELREELaeLEAELEQLEEDGELAELLQ----ELE 479
                        410
                 ....*....|..
gi 767925593 378 DLKNKLKAEEEK 389
Cdd:COG4717  480 ELKAELRELAEE 491
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
94-583 4.03e-06

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 50.94  E-value: 4.03e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593    94 QEEEQKATRLE----KELQTQTTKFHQDQDTIMAKLTNEDSQnrqLQQKLAALSRQIDELEETNRSL--RKAEEE--LQD 165
Cdd:pfam01576    3 QEEEMQAKEEElqkvKERQQKAESELKELEKKHQQLCEEKNA---LQEQLQAETELCAEAEEMRARLaaRKQELEeiLHE 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   166 IKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEElikmEEQCRDlNKRLERETLQSKdfkleVEKLSKRIMALEKLEDA 245
Cdd:pfam01576   80 LESRLEEEEERSQQLQNEKKKMQQHIQDLEEQLDE----EEAARQ-KLQLEKVTTEAK-----IKKLEEDILLLEDQNSK 149
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   246 FNKSK----QECYSLKCNLEKERMTTKQLSQ-------ELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVD 314
Cdd:pfam01576  150 LSKERklleERISEFTSNLAEEEEKAKSLSKlknkheaMISDLEERLKKEEKGRQELEKAKRKLEGESTDLQEQIAELQA 229
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   315 ERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVE-EKMY--SVTKERDDLKNKLKAEEEKGN 391
Cdd:pfam01576  230 QIAELRAQLAKKEEELQAALARLEEETAQKNNALKKIRELEAQISELQEDLEsERAArnKAEKQRRDLGEELEALKTELE 309
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   392 DLLSRVNMlKNRLQSLEAIEKDFLKNKLnQDSGKSTTALHQE-----NNKIKELSQEVE---RLKLKL-KDMKAIEDDLM 462
Cdd:pfam01576  310 DTLDTTAA-QQELRSKREQEVTELKKAL-EEETRSHEAQLQEmrqkhTQALEELTEQLEqakRNKANLeKAKQALESENA 387
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   463 KTEDEYETL-----ERRYANERDKAQFLSKELEHVKMELAKYKLAEKTE--TSHEQWLFKRLQEEEAKSGHLSREVDALK 535
Cdd:pfam01576  388 ELQAELRTLqqakqDSEHKRKKLEGQLQELQARLSESERQRAELAEKLSklQSELESVSSLLNEAEGKNIKLSKDVSSLE 467
                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 767925593   536 EKIHEY-----------MATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKEL 583
Cdd:pfam01576  468 SQLQDTqellqeetrqkLNLSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQL 526
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
283-579 4.09e-06

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 50.84  E-value: 4.09e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   283 ELEAIESRLEKTEFTLKEDLTKLKTLTvmfvDERKTmSEKLKKTEDKLQAASSQLQVEQNKVTtvtEKLIEETKRALKSK 362
Cdd:TIGR02169  178 ELEEVEENIERLDLIIDEKRQQLERLR----REREK-AERYQALLKEKREYEGYELLKEKEAL---ERQKEAIERQLASL 249
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   363 TDVEEKmysVTKERDDLKNKLKAEEEKGNDLLSRVNmlknRLQSLEAIEkdfLKNKLnqdsGKSTTALHQENNKIKELSQ 442
Cdd:TIGR02169  250 EEELEK---LTEEISELEKRLEEIEQLLEELNKKIK----DLGEEEQLR---VKEKI----GELEAEIASLERSIAEKER 315
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   443 EVERLKLKLKDmkaIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKyklaektetsheqwLFKRLQEEEA 522
Cdd:TIGR02169  316 ELEDAEERLAK---LEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELED--------------LRAELEEVDK 378
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 767925593   523 KSGHLSREVDALKEKIHEYmatEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENL 579
Cdd:TIGR02169  379 EFAETRDELKDYREKLEKL---KREINELKRELDRLQEELQRLSEELADLNAAIAGI 432
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
96-246 4.79e-06

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 50.24  E-value: 4.79e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  96 EEQKATRLEKELQT-QTTKFHQDQDtimakLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGE 174
Cdd:COG2433  383 EELIEKELPEEEPEaEREKEHEERE-----LTEEEEEIRRLEEQVERLEAEVEELEAELEEKDERIERLERELSEARSEE 457
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767925593 175 YGNAGIMAEVEELRKRVLDMEGkdeELIKMEEQCRDLNKRLER-ETLQSKDFK------LEVEKLSKRimALEKLEDAF 246
Cdd:COG2433  458 RREIRKDREISRLDREIERLER---ELEEERERIEELKRKLERlKELWKLEHSgelvpvKVVEKFTKE--AIRRLEEEY 531
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
168-497 8.79e-06

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 49.63  E-value: 8.79e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 168 EKISKGEYGNAGIMAEVEELR-----KRVLDMEGKDEELI----KMEEQCRDLNKRLE-RETLQSKDFKLEVE----KLS 233
Cdd:COG3206   71 SGLSSLSASDSPLETQIEILKsrpvlERVVDKLNLDEDPLgeeaSREAAIERLRKNLTvEPVKGSNVIEISYTspdpELA 150
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 234 KRImaLEKLEDAFNKskqecYSLKCNLEKERMTTKQLSQELESLKvriKELEAIESRLEktEFTLKEDLTKLKtltvmfv 313
Cdd:COG3206  151 AAV--ANALAEAYLE-----QNLELRREEARKALEFLEEQLPELR---KELEEAEAALE--EFRQKNGLVDLS------- 211
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 314 DERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLieETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDL 393
Cdd:COG3206  212 EEAKLLLQQLSELESQLAEARAELAEAEARLAALRAQL--GSGPDALPELLQSPVIQQLRAQLAELEAELAELSARYTPN 289
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 394 LSRVNMLKNRLQSLEAiekdflknKLNQDSGKSTTALHQEnnkIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLER 473
Cdd:COG3206  290 HPDVIALRAQIAALRA--------QLQQEAQRILASLEAE---LEALQAREASLQAQLAQLEARLAELPELEAELRRLER 358
                        330       340
                 ....*....|....*....|....
gi 767925593 474 RYANERDKAQFLSKELEHVKMELA 497
Cdd:COG3206  359 EVEVARELYESLLQRLEEARLAEA 382
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
5-587 1.06e-05

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 49.58  E-value: 1.06e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593     5 KKQDAEEQCLLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTT----NAK 80
Cdd:pfam02463  238 RIDLLQELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVddeeKLK 317
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593    81 ETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRsLRKAE 160
Cdd:pfam02463  318 ESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAK-LKEEE 396
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   161 EELQDIKEKISKGEygnagimAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMaLE 240
Cdd:pfam02463  397 LELKSEEEKEAQLL-------LELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELE-LK 468
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   241 KLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVD---ERK 317
Cdd:pfam02463  469 KSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKvaiSTA 548
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   318 TMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEkmysvTKERDDLKNKLKAEEEKGNDLLSRV 397
Cdd:pfam02463  549 VIVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLE-----IDPILNLAQLDKATLEADEDDKRAK 623
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   398 NMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTA--LHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRY 475
Cdd:pfam02463  624 VVEGILKDTELTKLKESAKAKESGLRKGVSLEegLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKK 703
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   476 ANERDKAQFLSKELEHVKMELAKYKLAE---KTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQ 552
Cdd:pfam02463  704 KEQREKEELKKLKLEAEELLADRVQEAQdkiNEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKT 783
                          570       580       590
                   ....*....|....*....|....*....|....*
gi 767925593   553 GDHSVLQKKLNQQENRNRDLGREIENLTKELERYR 587
Cdd:pfam02463  784 EKLKVEEEKEEKLKAQEEELRALEEELKEEAELLE 818
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
6-302 1.18e-05

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 49.25  E-value: 1.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593    6 KQDAEEQCLLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSfalmvvdEQQRLTAQLTLQRQKIQELTTNAKETHTK 85
Cdd:TIGR04523 397 ESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNS-------EIKDLTNQDSVKELIIKNLDNTRESLETQ 469
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   86 LALAEARVQEEEQKATRLEKELQTQTTkfhqdqdtimaKLTNEDSQNRQLQQKLAALSRQIDELEETNRSL----RKAEE 161
Cdd:TIGR04523 470 LKVLSRSINKIKQNLEQKQKELKSKEK-----------ELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLesekKEKES 538
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  162 ELQDIKEKISKGEYG--NAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLEretlqsKDFKLEVEKLSKRIMAL 239
Cdd:TIGR04523 539 KISDLEDELNKDDFElkKENLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKE------KEKKDLIKEIEEKEKKI 612
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767925593  240 EKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDL 302
Cdd:TIGR04523 613 SSLEKELEKAKKENEKLSSIIKNIKSKKNKLKQEVKQIKETIKEIRNKWPEIIKKIKESKTKI 675
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
124-343 1.19e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 48.67  E-value: 1.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 124 KLTNEDSQNRQLQQKLAALSRQID----ELEETNRSLRKAEEELQDIKEKISKGEygnagimAEVEELRKRVldmegkDE 199
Cdd:COG3883   17 QIQAKQKELSELQAELEAAQAELDalqaELEELNEEYNELQAELEALQAEIDKLQ-------AEIAEAEAEI------EE 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 200 ELIKMEEQCRDLNKRLERET-----LQSKDFklevEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERmttKQLSQEL 274
Cdd:COG3883   84 RREELGERARALYRSGGSVSyldvlLGSESF----SDFLDRLSALSKIADADADLLEELKADKAELEAKK---AELEAKL 156
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767925593 275 ESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNK 343
Cdd:COG3883  157 AELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAA 225
EzrA pfam06160
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...
122-474 1.31e-05

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.


Pssm-ID: 428797 [Multi-domain]  Cd Length: 542  Bit Score: 49.08  E-value: 1.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  122 MAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISK------GEYGNAgimaeVEELRKRVLDME 195
Cdd:pfam06160  85 KKALDEIEELLDDIEEDIKQILEELDELLESEEKNREEVEELKDKYRELRKtllanrFSYGPA-----IDELEKQLAEIE 159
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  196 GKDEEL---------IKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRI-MALEKLEDAFNKSKQECYSLK-CNLEKER 264
Cdd:pfam06160 160 EEFSQFeeltesgdyLEAREVLEKLEEETDALEELMEDIPPLYEELKTELpDQLEELKEGYREMEEEGYALEhLNVDKEI 239
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  265 mttKQLSQELESLKVRIKELEaiesrLEKTEFTLKEDLTKLKTLTVMF---VDERKTMSEKLKKTEDKLQAASSQLQVEQ 341
Cdd:pfam06160 240 ---QQLEEQLEENLALLENLE-----LDEAEEALEEIEERIDQLYDLLekeVDAKKYVEKNLPEIEDYLEHAEEQNKELK 311
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  342 NKVTTVTEKLI---EETKRALKSKTDVE--EKMYSVTKERDD--------LKNKLKAEEEKGNDLLSRVNMLKNRLQSLE 408
Cdd:pfam06160 312 EELERVQQSYTlneNELERVRGLEKQLEelEKRYDEIVERLEekevayseLQEELEEILEQLEEIEEEQEEFKESLQSLR 391
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  409 AIEKDFLKNKLNQDSGKSTTALHQEN------------------NKIKELSQEVERLKLklkDMKAIEDDLMKTEDEYET 470
Cdd:pfam06160 392 KDELEAREKLDEFKLELREIKRLVEKsnlpglpesyldyffdvsDEIEDLADELNEVPL---NMDEVNRLLDEAQDDVDT 468

                  ....
gi 767925593  471 LERR 474
Cdd:pfam06160 469 LYEK 472
46 PHA02562
endonuclease subunit; Provisional
85-324 2.22e-05

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 48.09  E-value: 2.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  85 KLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQ-QKLAALSRQID-ELEETNRSLRKAEEE 162
Cdd:PHA02562 170 KLNKDKIRELNQQIQTLDMKIDHIQQQIKTYNKNIEEQRKKNGENIARKQNKyDELVEEAKTIKaEIEELTDELLNLVMD 249
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 163 LQDIKEKISKGEYGNAGIMAEVEELRKrVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKL 242
Cdd:PHA02562 250 IEDPSAALNKLNTAAAKIKSKIEQFQK-VIKMYEKGGVCPTCTQQISEGPDRITKIKDKLKELQHSLEKLDTAIDELEEI 328
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 243 EDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAiESRLEKTEF-TLKEDLTKL---KTLTVMFVDERKT 318
Cdd:PHA02562 329 MDEFNEQSKKLLELKNKISTNKQSLITLVDKAKKVKAAIEELQA-EFVDNAEELaKLQDELDKIvktKSELVKEKYHRGI 407

                 ....*.
gi 767925593 319 MSEKLK 324
Cdd:PHA02562 408 VTDLLK 413
PTZ00121 PTZ00121
MAEBL; Provisional
79-465 2.66e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 48.21  E-value: 2.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   79 AKETHTKLALAEARVQEEEQKATRLEK--------ELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELE 150
Cdd:PTZ00121 1527 AKKAEEAKKADEAKKAEEKKKADELKKaeelkkaeEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKK 1606
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  151 ETNRSLRKAEEE---------LQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQcrdlnkrlerETLQ 221
Cdd:PTZ00121 1607 MKAEEAKKAEEAkikaeelkkAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEE----------DKKK 1676
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  222 SKDFKLEVEKLSKRIMALEKLEDAFNKSKQecysLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKED 301
Cdd:PTZ00121 1677 AEEAKKAEEDEKKAAEALKKEAEEAKKAEE----LKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKD 1752
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  302 LTKLKTLTVMFVDERKTMSEKLKKTEdklqaassqlQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKN 381
Cdd:PTZ00121 1753 EEEKKKIAHLKKEEEKKAEEIRKEKE----------AVIEEELDEEDEKRRMEVDKKIKDIFDNFANIIEGGKEGNLVIN 1822
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  382 KLK-AEEEKGNDLLSRVNMLKNRLQSLEaiEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVErlklKLKDMKAIEDD 460
Cdd:PTZ00121 1823 DSKeMEDSAIKEVADSKNMQLEEADAFE--KHKFNKNNENGEDGNKEADFNKEKDLKEDDEEEIE----EADEIEKIDKD 1896

                  ....*
gi 767925593  461 LMKTE 465
Cdd:PTZ00121 1897 DIERE 1901
COG5022 COG5022
Myosin heavy chain [General function prediction only];
15-635 2.80e-05

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 48.15  E-value: 2.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   15 LKKLIDQEIKSQEEKEQEKEKRVTTLKEELTK----LKSFALMVVDEQQRLTAQ-LTLQRQKIQELTTNAKEThTKLALa 89
Cdd:COG5022   822 LQKTIKREKKLRETEEVEFSLKAEVLIQKFGRslkaKKRFSLLKKETIYLQSAQrVELAERQLQELKIDVKSI-SSLKL- 899
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   90 earVQEE-EQKATRLEKELQT---QTTKFHQDQDTIMAKLTN----EDSQNRQLQQKlaalsRQIDELEETNRSLRKAEE 161
Cdd:COG5022   900 ---VNLElESEIIELKKSLSSdliENLEFKTELIARLKKLLNnidlEEGPSIEYVKL-----PELNKLHEVESKLKETSE 971
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  162 ELQDIKEKISKgeygnagimaEVEELRKRVLDMEGKDEELIKMeeqcRDLNKRLERETLQSKDFKLEVEKLsKRIMALEK 241
Cdd:COG5022   972 EYEDLLKKSTI----------LVREGNKANSELKNFKKELAEL----SKQYGALQESTKQLKELPVEVAEL-QSASKIIS 1036
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  242 LEDAFNKSKQECYSLKCNLEKERMttkQLSQELESLKVRIKELEAIESRLEKTEFTlkedLTKLKTLTVMFVDERKTMSE 321
Cdd:COG5022  1037 SESTELSILKPLQKLKGLLLLENN---QLQARYKALKLRRENSLLDDKQLYQLEST----ENLLKTINVKDLEVTNRNLV 1109
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  322 KLKKTEDKLQAASSQLQVEQN-------KVTTV-----TEKLIEETKRALKSKTDVEEKMYSV----TKERDDLKNKLKA 385
Cdd:COG5022  1110 KPANVLQFIVAQMIKLNLLQEiskflsqLVNTLepvfqKLSVLQLELDGLFWEANLEALPSPPpfaaLSEKRLYQSALYD 1189
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  386 EEEKGNDllSRVNMLKNRLQSLEAIEK-DFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLK--------LKDMKA 456
Cdd:COG5022  1190 EKSKLSS--SEVNDLKNELIALFSKIFsGWPRGDKLKKLISEGWVPTEYSTSLKGFNNLNKKFDTPasmsneklLSLLNS 1267
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  457 IEDDLMKTEDEYETLERRyanerdkaqfLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKE 536
Cdd:COG5022  1268 IDNLLSSYKLEEEVLPAT----------INSLLQYINVGLFNALRTKASSLRWKSATEVNYNSEELDDWCREFEISDVDE 1337
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  537 KIHEYMATEDLICHLQGDHSVLQKKLNQQENRN----RDLGREIENLTKELERYRHFSKSLRPSLNGRR--ISDPQVFSK 610
Cdd:COG5022  1338 ELEELIQAVKVLQLLKDDLNKLDELLDACYSLNpaeiQNLKSRYDPADKENNLPKEILKKIEALLIKQElqLSLEGKDET 1417
                         650       660
                  ....*....|....*....|....*
gi 767925593  611 EVQTEAVDNEppdYKSLIPLERAVI 635
Cdd:COG5022  1418 EVHLSEIFSE---EKSLISLDRNSI 1439
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
59-221 2.93e-05

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 46.46  E-value: 2.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  59 QRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNrqLQQK 138
Cdd:COG1579   20 DRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVRNNKEYEA--LQKE 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 139 LAALSRQIDELEEtnrSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRV-LDMEGKDEELIKMEEQCRDLNKRLER 217
Cdd:COG1579   98 IESLKRRISDLED---EILELMERIEELEEELAELEAELAELEAELEEKKAELdEELAELEAELEELEAEREELAAKIPP 174

                 ....
gi 767925593 218 ETLQ 221
Cdd:COG1579  175 ELLA 178
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
404-587 3.48e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 47.45  E-value: 3.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 404 LQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANERDKAQ 483
Cdd:COG4717   40 LAFIRAMLLERLEKEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELE 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 484 FLSKELEHVKMELAKYKLAEKTETSHEQWlfKRLQEEEAKSGHLSREVDALKEKIHEY------------MATEDLICHL 551
Cdd:COG4717  120 KLEKLLQLLPLYQELEALEAELAELPERL--EELEERLEELRELEEELEELEAELAELqeeleelleqlsLATEEELQDL 197
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 767925593 552 QGDHSVLQKKLNQQENRNRDLGREIENLTKELERYR 587
Cdd:COG4717  198 AEELEELQQRLAELEEELEEAQEELEELEEELEQLE 233
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
40-593 3.48e-05

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 47.86  E-value: 3.48e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593    40 LKEELTKLKSFALMVVDEQQRLTAQLtlqrQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQD 119
Cdd:pfam01576  389 LQAELRTLQQAKQDSEHKRKKLEGQL----QELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNIKLSKDVS 464
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   120 TIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKgeygnagimaEVEELRKRVLDMEGKDE 199
Cdd:pfam01576  465 SLESQLQDTQELLQEETRQKLNLSTRLRQLEDERNSLQEQLEEEEEAKRNVER----------QLSTLQAQLSDMKKKLE 534
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   200 ELIKMEEQCRDLNKRLEREtLQSKDFKLEveklsKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKV 279
Cdd:pfam01576  535 EDAGTLEALEEGKKRLQRE-LEALTQQLE-----EKAAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSNLEKKQKKFDQ 608
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   280 RIKELEAIESRL----EKTEFTLKEDLTKLKTLTVMfVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLiEET 355
Cdd:pfam01576  609 MLAEEKAISARYaeerDRAEAEAREKETRALSLARA-LEEALEAKEELERTNKQLRAEMEDLVSSKDDVGKNVHEL-ERS 686
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   356 KRALksktdvEEKMYSVTKERDDLKNKLKAEEEKgnDLLSRVNMlknrlQSLEAIEKDFLKNKLNQDSGKSTTALHQENN 435
Cdd:pfam01576  687 KRAL------EQQVEEMKTQLEELEDELQATEDA--KLRLEVNM-----QALKAQFERDLQARDEQGEEKRRQLVKQVRE 753
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   436 KIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYAN-----ERDKAQF--LSKELEHVKME----LAKYKLAEK 504
Cdd:pfam01576  754 LEAELEDERKQRAQAVAAKKKLELDLKELEAQIDAANKGREEavkqlKKLQAQMkdLQRELEEARASrdeiLAQSKESEK 833
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   505 TETSHEQWLFkRLQEEEAKSGHLSREVDALKEKIHEYMAT---------------EDLICHLQGDHSVLQKKLNQQENRN 569
Cdd:pfam01576  834 KLKNLEAELL-QLQEDLAASERARRQAQQERDELADEIASgasgksalqdekrrlEARIAQLEEELEEEQSNTELLNDRL 912
                          570       580
                   ....*....|....*....|....
gi 767925593   570 RDLGREIENLTKELERYRHFSKSL 593
Cdd:pfam01576  913 RKSTLQVEQLTTELAAERSTSQKS 936
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
40-285 4.36e-05

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 47.37  E-value: 4.36e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593    40 LKEELTKLK-----SFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLE---KELQTQT 111
Cdd:TIGR02169  777 LEEALNDLEarlshSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKeqiKSIEKEI 856
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   112 TKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQdikekiskgeygnagimAEVEELRKRV 191
Cdd:TIGR02169  857 ENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELE-----------------AQIEKKRKRL 919
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   192 LDMEGKDEELIKMEEQCRDLNKRLE---RETLQSKDFKLEVEKLSKRIMALE----KLEDAFNKSKQECYSLKCNLEKer 264
Cdd:TIGR02169  920 SELKAKLEALEEELSEIEDPKGEDEeipEEELSLEDVQAELQRVEEEIRALEpvnmLAIQEYEEVLKRLDELKEKRAK-- 997
                          250       260
                   ....*....|....*....|.
gi 767925593   265 mttkqLSQELESLKVRIKELE 285
Cdd:TIGR02169  998 -----LEEERKAILERIEEYE 1013
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
54-696 4.65e-05

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 47.35  E-value: 4.65e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593    54 VVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLE----------KELQTQTTKFHQDQDTIMA 123
Cdd:TIGR00606  194 VRQTQGQKVQEHQMELKYLKQYKEKACEIRDQITSKEAQLESSREIVKSYEneldplknrlKEIEHNLSKIMKLDNEIKA 273
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   124 KLTNE---DSQNRQLQQKLA----ALSRQIDELEETN-RSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRV---- 191
Cdd:TIGR00606  274 LKSRKkqmEKDNSELELKMEkvfqGTDEQLNDLYHNHqRTVREKERELVDCQRELEKLNKERRLLNQEKTELLVEQgrlq 353
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   192 LDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFkLEVEKLSKRIMALEKLEDAFNKSKQECYSLKcnlEKERMTTKQLS 271
Cdd:TIGR00606  354 LQADRHQEHIRARDSLIQSLATRLELDGFERGPF-SERQIKNFHTLVIERQEDEAKTAAQLCADLQ---SKERLKQEQAD 429
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   272 QELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMfVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKL 351
Cdd:TIGR00606  430 EIRDEKKGLGRTIELKKEILEKKQEELKFVIKELQQLEGS-SDRILELDQELRKAERELSKAEKNSLTETLKKEVKSLQN 508
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   352 ----IEETKRALKSK-------TDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRV-------NMLKNRLQSLEA---I 410
Cdd:TIGR00606  509 ekadLDRKLRKLDQEmeqlnhhTTTRTQMEMLTKDKMDKDEQIRKIKSRHSDELTSLlgyfpnkKQLEDWLHSKSKeinQ 588
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   411 EKDFLKnKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDM---KAIEDDLMKTEDEYETLERRYANERDKAQFLSK 487
Cdd:TIGR00606  589 TRDRLA-KLNKELASLEQNKNHINNELESKEEQLSSYEDKLFDVcgsQDEESDLERLKEEIEKSSKQRAMLAGATAVYSQ 667
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   488 ELEHVKME------LAKYKLAEKTETsheQWLFKRLQEEEAKSGHLSREVDALKEKIHEymATEDLICHLQGDHSVLQ-- 559
Cdd:TIGR00606  668 FITQLTDEnqsccpVCQRVFQTEAEL---QEFISDLQSKLRLAPDKLKSTESELKKKEK--RRDEMLGLAPGRQSIIDlk 742
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   560 -KKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSLNGRRISDPQVFSKEVQTEAVDNEPPDYKSLIPLERAVINGQ 638
Cdd:TIGR00606  743 eKEIPELRNKLQKVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGSDLDR 822
                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 767925593   639 LYEESENQDEDPNDEGSVLSFKCSQSTPCPVNRKLWIPWMKSKEGHLQNGKMQTKPNA 696
Cdd:TIGR00606  823 TVQQVNQEKQEKQHELDTVVSKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIGTNL 880
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
268-524 4.99e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 46.68  E-value: 4.99e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 268 KQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLktltvmfvderktmSEKLKKTEDKLQAASSQLQVEQNKVTTV 347
Cdd:COG4942   23 AEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAAL--------------ERRIAALARRIRALEQELAALEAELAEL 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 348 TEKlIEETKRALKsktdveekmysvtKERDDLKNKLKAEEEKGNdlLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKST 427
Cdd:COG4942   89 EKE-IAELRAELE-------------AQKEELAELLRALYRLGR--QPPLALLLSPEDFLDAVRRLQYLKYLAPARREQA 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 428 TALHQENNKIKELSQEVERLKLKLKDMKAieddlmKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTET 507
Cdd:COG4942  153 EELRADLAELAALRAELEAERAELEALLA------ELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELE 226
                        250
                 ....*....|....*..
gi 767925593 508 SheqwLFKRLQEEEAKS 524
Cdd:COG4942  227 A----LIARLEAEAAAA 239
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
38-555 6.01e-05

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 46.89  E-value: 6.01e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593    38 TTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKAtRLEKELQTQTTKFHQD 117
Cdd:TIGR00618  365 TSIREISCQQHTLTQHIHTLQQQKTTLTQKLQSLCKELDILQREQATIDTRTSAFRDLQGQLA-HAKKQQELQQRYAELC 443
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   118 QDTIMAKLTNEDSQN---RQLQQKLAALSRQIDELE-------ETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEEL 187
Cdd:TIGR00618  444 AAAITCTAQCEKLEKihlQESAQSLKEREQQLQTKEqihlqetRKKAVVLARLLELQEEPCPLCGSCIHPNPARQDIDNP 523
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   188 RKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAF----NKSKQECYSLKCNLEKE 263
Cdd:TIGR00618  524 GPLTRRMQRGEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSkediPNLQNITVRLQDLTEKL 603
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   264 RMTTKQLSQELESLKVRiKELEAIESRLEKTEFTLKEDLTKLKT------LTVMFVDERKTMSEKLKKTEDKLQAASSQL 337
Cdd:TIGR00618  604 SEAEDMLACEQHALLRK-LQPEQDLQDVRLHLQQCSQELALKLTalhalqLTLTQERVREHALSIRVLPKELLASRQLAL 682
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   338 QVEQNKVTTVTEKLiEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAeeeKGNDLLSRVNMLKNRLQSLEAIEKDFLKN 417
Cdd:TIGR00618  683 QKMQSEKEQLTYWK-EMLAQCQTLLRELETHIEEYDREFNEIENASSS---LGSDLAAREDALNQSLKELMHQARTVLKA 758
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   418 KLNQDSGKSTTALHQE-------------NNKIKELSQEVERLKLKLKDMKA-IEDDLMKTEDEYETLERRYANERDKAQ 483
Cdd:TIGR00618  759 RTEAHFNNNEEVTAALqtgaelshlaaeiQFFNRLREEDTHLLKTLEAEIGQeIPSDEDILNLQCETLVQEEEQFLSRLE 838
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767925593   484 FLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMA--TEDLICHLQGDH 555
Cdd:TIGR00618  839 EKSATLGEITHQLLKYEECSKQLAQLTQEQAKIIQLSDKLNGINQIKIQFDGDALIKFLHeiTLYANVRLANQS 912
COG5022 COG5022
Myosin heavy chain [General function prediction only];
36-567 6.30e-05

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 46.99  E-value: 6.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   36 RVTTLKEELTKLKSFALMVV-DEQQRLTAQLTLQRQKIQELTTNAKETHTKLALA-EARVQEEEQKatrlekeLQTQTTK 113
Cdd:COG5022   893 SISSLKLVNLELESEIIELKkSLSSDLIENLEFKTELIARLKKLLNNIDLEEGPSiEYVKLPELNK-------LHEVESK 965
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  114 FHQDQDTIMAKLTNEDSQNRQLQ----------QKLAALSRQIDELEETNRSLRKAEEELQDIK--EKISKGEYGNAGIM 181
Cdd:COG5022   966 LKETSEEYEDLLKKSTILVREGNkanselknfkKELAELSKQYGALQESTKQLKELPVEVAELQsaSKIISSESTELSIL 1045
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  182 AEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQ-------SKDFKLEVEKLSKRIMALEKLEDAFNKSKQecy 254
Cdd:COG5022  1046 KPLQKLKGLLLLENNQLQARYKALKLRRENSLLDDKQLYQlestenlLKTINVKDLEVTNRNLVKPANVLQFIVAQM--- 1122
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  255 sLKCNLEKERMttkqlsqelESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAAS 334
Cdd:COG5022  1123 -IKLNLLQEIS---------KFLSQLVNTLEPVFQKLSVLQLELDGLFWEANLEALPSPPPFAALSEKRLYQSALYDEKS 1192
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  335 SQLQVEqnkVTTVTEKLIEETKR-------------ALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLK 401
Cdd:COG5022  1193 KLSSSE---VNDLKNELIALFSKifsgwprgdklkkLISEGWVPTEYSTSLKGFNNLNKKFDTPASMSNEKLLSLLNSID 1269
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  402 NRLQS-------LEAIEKDFLKN-----------KLNQDSGKSTTALHQ--ENNKIKELSQEVERLKLKLKDMKAIEDDL 461
Cdd:COG5022  1270 NLLSSykleeevLPATINSLLQYinvglfnalrtKASSLRWKSATEVNYnsEELDDWCREFEISDVDEELEELIQAVKVL 1349
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  462 MKTEDEYETLERRYanerdKAQFLSKELEHVKMeLAKYKLAEKtETSHEQWLFKRLQEEEAKS--GHLSREVDALKEKIH 539
Cdd:COG5022  1350 QLLKDDLNKLDELL-----DACYSLNPAEIQNL-KSRYDPADK-ENNLPKEILKKIEALLIKQelQLSLEGKDETEVHLS 1422
                         570       580
                  ....*....|....*....|....*...
gi 767925593  540 EYMATEDLICHLQGDHSVLQKKLNQQEN 567
Cdd:COG5022  1423 EIFSEEKSLISLDRNSIYKEEVLSSLSA 1450
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
238-594 7.14e-05

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 46.89  E-value: 7.14e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   238 ALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERK 317
Cdd:pfam02463  174 ALKKLIEETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQELLRDEQEEI 253
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   318 TMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKtdvEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRV 397
Cdd:pfam02463  254 ESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEEL---KSELLKLERRKVDDEEKLKESEKEKKKAEKEL 330
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   398 NMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNKIKElsqevERLKLKLKDMKAIEDDLMKTEDEYETLERRYAN 477
Cdd:pfam02463  331 KKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLE-----EELLAKKKLESERLSSAAKLKEEELELKSEEEK 405
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   478 ERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKR--------LQEEEAKSGHLSREVDALKEKIHEYMATEDLIC 549
Cdd:pfam02463  406 EAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGklteekeeLEKQELKLLKDELELKKSEDLLKETQLVKLQEQ 485
                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*
gi 767925593   550 HLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLR 594
Cdd:pfam02463  486 LELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGR 530
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
195-398 7.62e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 46.83  E-value: 7.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  195 EGKDEELIKMEEQCRDLNKRLEretlqskDFKLEVEKLSKRIMALEKLEDAFN-----KSKQECYSlkcNLEKERMTTKQ 269
Cdd:COG4913   613 AALEAELAELEEELAEAEERLE-------ALEAELDALQERREALQRLAEYSWdeidvASAEREIA---ELEAELERLDA 682
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  270 LSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKtltvmfvDERKTMSEKLKKTEDKLQAASSQLQVEQnkvttvtE 349
Cdd:COG4913   683 SSDDLAALEEQLEELEAELEELEEELDELKGEIGRLE-------KELEQAEEELDELQDRLEAAEDLARLEL-------R 748
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 767925593  350 KLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVN 398
Cdd:COG4913   749 ALLEERFAAALGDAVERELRENLEERIDALRARLNRAEEELERAMRAFN 797
COG5283 COG5283
Phage-related tail protein [Mobilome: prophages, transposons];
49-215 7.65e-05

Phage-related tail protein [Mobilome: prophages, transposons];


Pssm-ID: 444094 [Multi-domain]  Cd Length: 747  Bit Score: 46.77  E-value: 7.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  49 SFALMVVDeqQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMA---KL 125
Cdd:COG5283    2 QVILGAVD--KPFKSALESAKQRVAALAQALKALEAPTRALARALERAKQAAARLQTKYNKLRQSLQRLRQALDQagiDT 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 126 TNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISK-GEYGNAGI-------------------MAEVe 185
Cdd:COG5283   80 RQLSAAQRRLRSSLEQTNRQLERQQQRLARLGARQDRLKAARARLQRlAGAGAAAAaigaalaasvkpaidfedaMADV- 158
                        170       180       190
                 ....*....|....*....|....*....|
gi 767925593 186 elrKRVLDMEGKDEELIKMEEQCRDLNKRL 215
Cdd:COG5283  159 ---AATVDLDKSSEQFKALGKQARELSAQT 185
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
16-523 7.99e-05

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 46.58  E-value: 7.99e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593    16 KKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQE 95
Cdd:TIGR00606  572 KKQLEDWLHSKSKEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDKLFDVCGSQDEESDLERLKEEIEKS 651
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593    96 EEQKA-----TRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQI-DELEETNRSLRKAEEELQDIKEK 169
Cdd:TIGR00606  652 SKQRAmlagaTAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEFISDLQSKLRLApDKLKSTESELKKKEKRRDEMLGL 731
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   170 ISKGEYGNAGIMAEVEELRKRV----LDMEGKDEELIKMEEQCRDLNKRLEretlQSKDFKLEVEKLSKRIMALEKLEDA 245
Cdd:TIGR00606  732 APGRQSIIDLKEKEIPELRNKLqkvnRDIQRLKNDIEEQETLLGTIMPEEE----SAKVCLTDVTIMERFQMELKDVERK 807
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   246 FNK--SKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMF---VDERKTMS 320
Cdd:TIGR00606  808 IAQqaAKLQGSDLDRTVQQVNQEKQEKQHELDTVVSKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIgtnLQRRQQFE 887
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   321 EKLKKTEDKLQAASSQLQVEQNKVT---TVTEKLIEETKRALKSK-----------TDVEEKMYSVTKERDDLKNKLKAE 386
Cdd:TIGR00606  888 EQLVELSTEVQSLIREIKDAKEQDSpleTFLEKDQQEKEELISSKetsnkkaqdkvNDIKEKVKNIHGYMKDIENKIQDG 967
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   387 EE-----KGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQEN-------NKIKELSQEVERLKLKLKDM 454
Cdd:TIGR00606  968 KDdylkqKETELNTVNAQLEECEKHQEKINEDMRLMRQDIDTQKIQERWLQDNltlrkreNELKEVEEELKQHLKEMGQM 1047
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767925593   455 KAIE--DDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAK 523
Cdd:TIGR00606 1048 QVLQmkQEHQKLEENIDLIKRNHVLALGRQKGYEKEIKHFKKELREPQFRDAEEKYREMMIVMRTTELVNK 1118
PRK12704 PRK12704
phosphodiesterase; Provisional
156-305 9.17e-05

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 46.31  E-value: 9.17e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 156 LRKAEEELQDIKEKISKgeygnagimaEVEELRKRVLdMEGKDEELIKMEEQCRDLNKRleRETLQSKDFKLE--VEKLS 233
Cdd:PRK12704  33 IKEAEEEAKRILEEAKK----------EAEAIKKEAL-LEAKEEIHKLRNEFEKELRER--RNELQKLEKRLLqkEENLD 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 234 KRIMALEKLEDAFNKSKQECYSLKCNLEK-----ERMTTKQLsQELEslkvRIKEL---EAIESRLEKTEFTLKEDLTKL 305
Cdd:PRK12704 100 RKLELLEKREEELEKKEKELEQKQQELEKkeeelEELIEEQL-QELE----RISGLtaeEAKEILLEKVEEEARHEAAVL 174
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
36-167 9.43e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 46.16  E-value: 9.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  36 RVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKAT---------RLEKE 106
Cdd:COG3206  220 QLSELESQLAEARAELAEAEARLAALRAQLGSGPDALPELLQSPVIQQLRAQLAELEAELAELSARytpnhpdviALRAQ 299
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767925593 107 LQTQTTKFHQDQDTIMAKLtneDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIK 167
Cdd:COG3206  300 IAALRAQLQQEAQRILASL---EAELEALQAREASLQAQLAQLEARLAELPELEAELRRLE 357
PRK06975 PRK06975
bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed
58-164 1.05e-04

bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed


Pssm-ID: 235899 [Multi-domain]  Cd Length: 656  Bit Score: 46.25  E-value: 1.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  58 QQRL--TAQLTLQRQkiqelttNAKETHTklalAEARVQEEEqkatrlekeLQTQTTKFHQDQDTIMAKLTNEDSQNRQL 135
Cdd:PRK06975 345 NRKVdrLDQELVQRQ-------QANDAQT----AELRVKTEQ---------AQASVHQLDSQFAQLDGKLADAQSAQQAL 404
                         90       100       110
                 ....*....|....*....|....*....|.
gi 767925593 136 QQKLAALSRQID--ELEETNRSLRKAEEELQ 164
Cdd:PRK06975 405 EQQYQDLSRNRDdwMIAEVEQMLSSASQQLQ 435
CortBP2 pfam09727
Cortactin-binding protein-2; This entry is the first approximately 250 residues of ...
11-60 1.16e-04

Cortactin-binding protein-2; This entry is the first approximately 250 residues of cortactin-binding protein 2. In addition to being a positional candidate for autism this protein is expressed at highest levels in the brain in humans. The human protein has six associated ankyrin repeat domains pfam00023 towards the C-terminus which act as protein-protein interaction domains.


Pssm-ID: 462860 [Multi-domain]  Cd Length: 187  Bit Score: 44.13  E-value: 1.16e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 767925593   11 EQCLLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQR 60
Cdd:pfam09727 138 ERERLKQELEQEKAQQKRLEKELKKLLEKLEEELSKQKQIALLLVKERKR 187
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
140-308 1.80e-04

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 45.23  E-value: 1.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 140 AALSRQI-----DELEETNRSLRKAEEELQDIKEKISKGEygnagimAEVEELRKRVLDMEG----KDEELIKMEEQCRD 210
Cdd:COG2433  380 EALEELIekelpEEEPEAEREKEHEERELTEEEEEIRRLE-------EQVERLEAEVEELEAeleeKDERIERLERELSE 452
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 211 LNKRLERETLQSKdfklEVEKLSKRIMALEKledafnkskqecyslkcnlekermttkqlsqELESLKVRIKELEAIESR 290
Cdd:COG2433  453 ARSEERREIRKDR----EISRLDREIERLER-------------------------------ELEEERERIEELKRKLER 497
                        170
                 ....*....|....*....
gi 767925593 291 LEKTEFTL-KEDLTKLKTL 308
Cdd:COG2433  498 LKELWKLEhSGELVPVKVV 516
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
61-218 2.14e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 45.01  E-value: 2.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  61 LTAQLTLQRQKIQELTTnakethtKLALAEARVQEEEQKATRLEKELqtqttkfhqDQDTIMAKLTNEDSQNRQLQQKLA 140
Cdd:COG3206  210 LSEEAKLLLQQLSELES-------QLAEARAELAEAEARLAALRAQL---------GSGPDALPELLQSPVIQQLRAQLA 273
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 141 ALSRQIDELE----ETNRSLRKAEEELQDIKEKISK-GEYGNAGIMAEVEELRKRVLDMEgkdEELIKMEEQCRDLNK-- 213
Cdd:COG3206  274 ELEAELAELSarytPNHPDVIALRAQIAALRAQLQQeAQRILASLEAELEALQAREASLQ---AQLAQLEARLAELPEle 350

                 ....*....
gi 767925593 214 ----RLERE 218
Cdd:COG3206  351 aelrRLERE 359
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
141-597 2.34e-04

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 45.04  E-value: 2.34e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   141 ALSRQIDELEETNRSLrKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETL 220
Cdd:TIGR00606  170 ALKQKFDEIFSATRYI-KALETLRQVRQTQGQKVQEHQMELKYLKQYKEKACEIRDQITSKEAQLESSREIVKSYENELD 248
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   221 QSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQEleslkvrikELEAIESRLEKTEFTLKE 300
Cdd:TIGR00606  249 PLKNRLKEIEHNLSKIMKLDNEIKALKSRKKQMEKDNSELELKMEKVFQGTDE---------QLNDLYHNHQRTVREKER 319
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   301 DLTKLKTLTVMFVDERKTMSEklKKTEDKLQAASSQLQVEQNKVTTVTEKLiEETKRALKSKTDVEEKMYSVTKErddLK 380
Cdd:TIGR00606  320 ELVDCQRELEKLNKERRLLNQ--EKTELLVEQGRLQLQADRHQEHIRARDS-LIQSLATRLELDGFERGPFSERQ---IK 393
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   381 NKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTT------ALHQENNKIKELSQEVERLKLKLKDM 454
Cdd:TIGR00606  394 NFHTLVIERQEDEAKTAAQLCADLQSKERLKQEQADEIRDEKKGLGRTielkkeILEKKQEELKFVIKELQQLEGSSDRI 473
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   455 KAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTE---------TSHEQWLFKRLQEEEAKSG 525
Cdd:TIGR00606  474 LELDQELRKAERELSKAEKNSLTETLKKEVKSLQNEKADLDRKLRKLDQEMEqlnhhtttrTQMEMLTKDKMDKDEQIRK 553
                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767925593   526 HLSREVDALKEKIHEYMATEDLICHLQGdhsvLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPSL 597
Cdd:TIGR00606  554 IKSRHSDELTSLLGYFPNKKQLEDWLHS----KSKEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQL 621
CCCAP pfam15964
Centrosomal colon cancer autoantigen protein family; CCCAP is a family of proteins found in ...
36-419 2.43e-04

Centrosomal colon cancer autoantigen protein family; CCCAP is a family of proteins found in eukaryotes. CCCAP is also known as SDCCAG8, serologically defined colon cancer antigen 8. It is associated with the centrosome.


Pssm-ID: 435040 [Multi-domain]  Cd Length: 703  Bit Score: 44.90  E-value: 2.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   36 RVTTLKEEL-TKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKF 114
Cdd:pfam15964 304 RLTKERDDLmSALVSVRSSLAEAQQRESSAYEQVKQAVQMTEEANFEKTKALIQCEQLKSELERQKERLEKELASQQEKR 383
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  115 HQDQDTIMAKLTNEDSQNRQ----LQQKLAALSRQIDELEETNRSLRKAEEELQ---------------DIKEKISKGEY 175
Cdd:pfam15964 384 AQEKEALRKEMKKEREELGAtmlaLSQNVAQLEAQVEKVTREKNSLVSQLEEAQkqlasqemdvtkvcgEMRYQLNQTKM 463
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  176 GNAGIMAEVEELRKRVL-DMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKrimALEKLEDAFNKSKQECY 254
Cdd:pfam15964 464 KKDEAEKEHREYRTKTGrQLEIKDQEIEKLGLELSESKQRLEQAQQDAARAREECLKLTE---LLGESEHQLHLTRLEKE 540
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  255 SLKCNLEKE-RMTTKQLSQELESLKVRIKELEAiesRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAA 333
Cdd:pfam15964 541 SIQQSFSNEaKAQALQAQQREQELTQKMQQMEA---QHDKTVNEQYSLLTSQNTFIAKLKEECCTLAKKLEEITQKSRSE 617
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  334 SSQLQVEQNKVTTVTEKLIEETKRaLKSKTDVEEKMYSVTKER-DDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLeAIEK 412
Cdd:pfam15964 618 VEQLSQEKEYLQDRLEKLQKRNEE-LEEQCVQHGRMHERMKQRlRQLDKHCQATAQQLVQLLSKQNQLFKERQNL-TEEV 695

                  ....*..
gi 767925593  413 DFLKNKL 419
Cdd:pfam15964 696 QSLRSQV 702
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
57-221 2.72e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 44.93  E-value: 2.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  57 EQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKfHQDQDTIMAKLTNEDSQNRQLQ 136
Cdd:COG1196  664 GGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEE-LEEEALEEQLEAEREELLEELL 742
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 137 QKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLE 216
Cdd:COG1196  743 EEEELLEEEALEELPEPPDLEELERELERLEREIEALGPVNLLAIEEYEELEERYDFLSEQREDLEEARETLEEAIEEID 822

                 ....*
gi 767925593 217 RETLQ 221
Cdd:COG1196  823 RETRE 827
PTZ00440 PTZ00440
reticulocyte binding protein 2-like protein; Provisional
40-582 2.84e-04

reticulocyte binding protein 2-like protein; Provisional


Pssm-ID: 240419 [Multi-domain]  Cd Length: 2722  Bit Score: 45.21  E-value: 2.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   40 LKEELTKLKSFALMVVDEQqrltaqLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKF----- 114
Cdd:PTZ00440  693 LKKELQNLLSLKENIIKKQ------LNNIEQDISNSLNQYTIKYNDLKSSIEEYKEEEEKLEVYKHQIINRKNEFilhly 766
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  115 HQDQDTIMAKLTNED--SQNRQLQQKLAALSRQIDELEEtnrSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRvL 192
Cdd:PTZ00440  767 ENDKDLPDGKNTYEEflQYKDTILNKENKISNDINILKE---NKKNNQDLLNSYNILIQKLEAHTEKNDEELKQLLQK-F 842
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  193 DMEGKDEELIKMEEQCRDLNKRLEretlqskDFKLEVEKLSKRIMALEKLEDAFNKS---KQECYSLKCNLEKERMTTKQ 269
Cdd:PTZ00440  843 PTEDENLNLKELEKEFNENNQIVD-------NIIKDIENMNKNINIIKTLNIAINRSnsnKQLVEHLLNNKIDLKNKLEQ 915
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  270 LSQELES------------LKVRIKELEAIESRLEKTEFT-----LKEDLTKLKTLTVMFVDERKTMSEKLKKTED---- 328
Cdd:PTZ00440  916 HMKIINTdniiqkneklnlLNNLNKEKEKIEKQLSDTKINnlkmqIEKTLEYYDKSKENINGNDGTHLEKLDKEKDeweh 995
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  329 ---KLQAASSQLQVEQNKVTTVT----EKLIEETKRALKSK-TDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNML 400
Cdd:PTZ00440  996 fksEIDKLNVNYNILNKKIDDLIkkqhDDIIELIDKLIKEKgKEIEEKVDQYISLLEKMKTKLSSFHFNIDIKKYKNPKI 1075
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  401 KNRLQSLEAIEKDFLKNklnqdsgksttalhqennkIKELSQEVERLKLKLKDMKAIEDDLM-KTEDEYET----LERRY 475
Cdd:PTZ00440 1076 KEEIKLLEEKVEALLKK-------------------IDENKNKLIEIKNKSHEHVVNADKEKnKQTEHYNKkkksLEKIY 1136
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  476 ANERDkaqfLSKELEHVKMELAKYKLAEKTETSHEQWLF----KRLQEEEAKSGHLSREVDALKEKIHEYMAteDLICHL 551
Cdd:PTZ00440 1137 KQMEK----TLKELENMNLEDITLNEVNEIEIEYERILIdhivEQINNEAKKSKTIMEEIESYKKDIDQVKK--NMSKER 1210
                         570       580       590
                  ....*....|....*....|....*....|.
gi 767925593  552 QGDHSVLqkKLNQQENRNRDLGREIENLTKE 582
Cdd:PTZ00440 1211 NDHLTTF--EYNAYYDKATASYENIEELTTE 1239
PRK01156 PRK01156
chromosome segregation protein; Provisional
5-604 3.60e-04

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 44.51  E-value: 3.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   5 KKQDAEEQCLLKkLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFAlmvvDEQQRLTAQLtlqrqkiqelttnaKETHT 84
Cdd:PRK01156 203 KKQIADDEKSHS-ITLKEIERLSIEYNNAMDDYNNLKSALNELSSLE----DMKNRYESEI--------------KTAES 263
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  85 KLALAEARVQEEEQKATRLEKelqTQTTKFHQDQDTIMAKLTNEdSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQ 164
Cdd:PRK01156 264 DLSMELEKNNYYKELEERHMK---IINDPVYKNRNYINDYFKYK-NDIENKKQILSNIDAEINKYHAIIKKLSVLQKDYN 339
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 165 DIKEKISkgeygnagimaEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKled 244
Cdd:PRK01156 340 DYIKKKS-----------RYDDLNNQILELEGYEMDYNSYLKSIESLKKKIEEYSKNIERMSAFISEILKIQEIDPD--- 405
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 245 afnkskqecySLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEKTE-------------FTLKEDltKLKTLTVM 311
Cdd:PRK01156 406 ----------AIKKELNEINVKLQDISSKVSSLNQRIRALRENLDELSRNMemlngqsvcpvcgTTLGEE--KSNHIINH 473
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 312 FVDERKTMSEKLKKTEDKLQAASSQlQVEQNKVTTVTEKliEETKRALKSKTDVEEKMYSVTKERDDLkNKLKAEEEKGN 391
Cdd:PRK01156 474 YNEKKSRLEEKIREIEIEVKDIDEK-IVDLKKRKEYLES--EEINKSINEYNKIESARADLEDIKIKI-NELKDKHDKYE 549
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 392 DLLSRVNMLKnrLQSLEAIEKDFLkNKLNQDSGKSTTALHQE----NNKIKELSQEVERLKLKLKDMKA-IEDDLMKTED 466
Cdd:PRK01156 550 EIKNRYKSLK--LEDLDSKRTSWL-NALAVISLIDIETNRSRsneiKKQLNDLESRLQEIEIGFPDDKSyIDKSIREIEN 626
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 467 EYETLERRYANERDKA---QFLSKELEHVKMELAKYKLAEKTETSheqwLFKRLQEEEAKSGHLSREVDALKEKIHEYMA 543
Cdd:PRK01156 627 EANNLNNKYNEIQENKiliEKLRGKIDNYKKQIAEIDSIIPDLKE----ITSRINDIEDNLKKSRKALDDAKANRARLES 702
                        570       580       590       600       610       620
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767925593 544 TedlichlqgdHSVLQKKLNQQENRNRDLGREIENLTK------ELERYRH-FSKSLRPSLNGRRISD 604
Cdd:PRK01156 703 T----------IEILRTRINELSDRINDINETLESMKKikkaigDLKRLREaFDKSGVPAMIRKSASQ 760
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
347-534 4.92e-04

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 44.08  E-value: 4.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 347 VTEKLIEEtkralksKTDVEEKMYSVTKERDDlkNKLKAEEEKGNDLLSRVNMLKNRLQSLEaiekdflknklnqdsgks 426
Cdd:COG2433  381 ALEELIEK-------ELPEEEPEAEREKEHEE--RELTEEEEEIRRLEEQVERLEAEVEELE------------------ 433
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 427 ttalhqenNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANerdkaqfLSKELEHVKMELAkyKLAEKTE 506
Cdd:COG2433  434 --------AELEEKDERIERLERELSEARSEERREIRKDREISRLDREIER-------LERELEEERERIE--ELKRKLE 496
                        170       180
                 ....*....|....*....|....*....
gi 767925593 507 tsheqwLFKRLQEEEAKSGHLS-REVDAL 534
Cdd:COG2433  497 ------RLKELWKLEHSGELVPvKVVEKF 519
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
36-241 5.41e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 44.14  E-value: 5.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   36 RVTTLKEELTKLKSFALMVVD--EQQRLTAQLTLQRQKIQELTTNAKET------------HTKLALAEARVQEEEQKAT 101
Cdd:COG4913   226 AADALVEHFDDLERAHEALEDarEQIELLEPIRELAERYAAARERLAELeylraalrlwfaQRRLELLEAELEELRAELA 305
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  102 RLEKELQTQTTKFHQDQDTImakltnEDSQNRQLQ---QKLAALSRQIDELEETnrsLRKAEEELQDIKEKISKGEYGNA 178
Cdd:COG4913   306 RLEAELERLEARLDALREEL------DELEAQIRGnggDRLEQLEREIERLERE---LEERERRRARLEALLAALGLPLP 376
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767925593  179 GIMAEVEELRKRVldmegkDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEK 241
Cdd:COG4913   377 ASAEEFAALRAEA------AALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASLER 433
46 PHA02562
endonuclease subunit; Provisional
14-213 6.21e-04

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 43.46  E-value: 6.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  14 LLKKLIDQEIKS----QEEKEQEKEKRVTTLKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALA 89
Cdd:PHA02562 188 MKIDHIQQQIKTynknIEEQRKKNGENIARKQNKYDELVEEAKTIKAEIEELTDELLNLVMDIEDPSAALNKLNTAAAKI 267
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  90 EARVQEEEQKATRLEK--ELQTQTTKFHQDQDtIMAKLTNedsQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIK 167
Cdd:PHA02562 268 KSKIEQFQKVIKMYEKggVCPTCTQQISEGPD-RITKIKD---KLKELQHSLEKLDTAIDELEEIMDEFNEQSKKLLELK 343
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767925593 168 EKISKGEYG-------NAGIMAEVEELRKRVLDmegKDEELIKMEEQCRDLNK 213
Cdd:PHA02562 344 NKISTNKQSlitlvdkAKKVKAAIEELQAEFVD---NAEELAKLQDELDKIVK 393
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
54-155 6.96e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 43.21  E-value: 6.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  54 VVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNR 133
Cdd:COG4942  144 LAPARREQAEELRADLAELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAE 223
                         90       100
                 ....*....|....*....|..
gi 767925593 134 QLQQKLAALSRQIDELEETNRS 155
Cdd:COG4942  224 ELEALIARLEAEAAAAAERTPA 245
PRK01156 PRK01156
chromosome segregation protein; Provisional
119-628 7.86e-04

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 43.35  E-value: 7.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 119 DTIMAKLTNEDSQNRQLQQK---LAALSRQIDELEETNRSLRKAEEELQDikekiskgEYGNAgiMAEVEELRKRVLDME 195
Cdd:PRK01156 176 DMLRAEISNIDYLEEKLKSSnleLENIKKQIADDEKSHSITLKEIERLSI--------EYNNA--MDDYNNLKSALNELS 245
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 196 GKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRImaleklEDAFNKSKQEC---YSLKCNLEKERMTTKQLSQ 272
Cdd:PRK01156 246 SLEDMKNRYESEIKTAESDLSMELEKNNYYKELEERHMKII------NDPVYKNRNYIndyFKYKNDIENKKQILSNIDA 319
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 273 ELESLKVRIKELEAIESRLEKTEftlkedltklktltvmfvdERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLI 352
Cdd:PRK01156 320 EINKYHAIIKKLSVLQKDYNDYI-------------------KKKSRYDDLNNQILELEGYEMDYNSYLKSIESLKKKIE 380
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 353 EETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAiEKDFLKNKLNQDSGKST----- 427
Cdd:PRK01156 381 EYSKNIERMSAFISEILKIQEIDPDAIKKELNEINVKLQDISSKVSSLNQRIRALRE-NLDELSRNMEMLNGQSVcpvcg 459
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 428 TALHQE---------NNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLE-RRYANERDKAQFLSKELEHVKMELA 497
Cdd:PRK01156 460 TTLGEEksnhiinhyNEKKSRLEEKIREIEIEVKDIDEKIVDLKKRKEYLESEEiNKSINEYNKIESARADLEDIKIKIN 539
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 498 KYKlaektetsheqwlFKRLQEEEAKSGHLSREVDALKEKIHEY---MATEDLIC--HLQGDHSVLQKKLNQQENRNRDL 572
Cdd:PRK01156 540 ELK-------------DKHDKYEEIKNRYKSLKLEDLDSKRTSWlnaLAVISLIDieTNRSRSNEIKKQLNDLESRLQEI 606
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767925593 573 GREIENLTKELERYrhfSKSLRPSLNGRRISDPQVFSKEVQTEAVDNEPPDYKSLI 628
Cdd:PRK01156 607 EIGFPDDKSYIDKS---IREIENEANNLNNKYNEIQENKILIEKLRGKIDNYKKQI 659
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
40-218 8.69e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 43.13  E-value: 8.69e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593    40 LKEELTKLKSFALMVVDEQQRLTAQLTLQRQKIQE---------------------LTTNAKETHTKLALAEARVQEEEQ 98
Cdd:TIGR02169  803 LEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQElqeqridlkeqiksiekeienLNGKKEELEEELEELEAALRDLES 882
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593    99 KATRLEKE---LQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNR----------SLRKAEEELQD 165
Cdd:TIGR02169  883 RLGDLKKErdeLEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGedeeipeeelSLEDVQAELQR 962
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 767925593   166 IKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERE 218
Cdd:TIGR02169  963 VEEEIRALEPVNMLAIQEYEEVLKRLDELKEKRAKLEEERKAILERIEEYEKK 1015
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
319-538 9.30e-04

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 42.99  E-value: 9.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 319 MSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERddlKNKLKAEEEKGNDLLSRVN 398
Cdd:PRK05771  51 LLTKLSEALDKLRSYLPKLNPLREEKKKVSVKSLEELIKDVEEELEKIEKEIKELEEE---ISELENEIKELEQEIERLE 127
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 399 MLKN------RLQSLE-------AIEKDFLKNKLNQDSGKSTTALHQENNKI-------KELSQEVERLkLKLKDMKAIE 458
Cdd:PRK05771 128 PWGNfdldlsLLLGFKyvsvfvgTVPEDKLEELKLESDVENVEYISTDKGYVyvvvvvlKELSDEVEEE-LKKLGFERLE 206
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 459 -DDLMKTEDEYETLERRYANERDKAQFLSKELEHVKMELAKYKLAEKTETSHEqwlfkrLQEEE-----AKSGHL----- 527
Cdd:PRK05771 207 lEEEGTPSELIREIKEELEEIEKERESLLEELKELAKKYLEELLALYEYLEIE------LERAEalskfLKTDKTfaieg 280
                        250
                 ....*....|....
gi 767925593 528 ---SREVDALKEKI 538
Cdd:PRK05771 281 wvpEDRVKKLKELI 294
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
162-362 1.13e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 41.45  E-value: 1.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 162 ELQDIKEKISKgeygnagIMAEVEELRKRVLDMEgkdEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEK 241
Cdd:COG1579   11 DLQELDSELDR-------LEHRLKELPAELAELE---DELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEE 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 242 LEDAFNKSKQecYslkcnlekermttKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKtltvmfvDERKTMSE 321
Cdd:COG1579   81 QLGNVRNNKE--Y-------------EALQKEIESLKRRISDLEDEILELMERIEELEEELAELE-------AELAELEA 138
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 767925593 322 KLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSK 362
Cdd:COG1579  139 ELEEKKAELDEELAELEAELEELEAEREELAAKIPPELLAL 179
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
7-165 1.23e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.98  E-value: 1.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593    7 QDAEEQCLLKKLID---QEIKSQEEKEQEKEKRVTTLKEELTKLKSfALMVVDEQQ--RLTAQLTLQRQKIQELTTNAKE 81
Cdd:COG4913   285 FAQRRLELLEAELEelrAELARLEAELERLEARLDALREELDELEA-QIRGNGGDRleQLEREIERLERELEERERRRAR 363
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   82 THTKLALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEE 161
Cdd:COG4913   364 LEALLAALGLPLPASAEEFAALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNIPARLL 443

                  ....
gi 767925593  162 ELQD 165
Cdd:COG4913   444 ALRD 447
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
56-344 1.25e-03

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 43.02  E-value: 1.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   56 DEQQRLTAQLTLQRQKIQELttnaKETHTKLA--LAEARVQEEEQKATRLEkELQTQTTKFHQDQDTIMAKltneDSQNR 133
Cdd:COG3096   850 RELAQHRAQEQQLRQQLDQL----KEQLQLLNklLPQANLLADETLADRLE-ELREELDAAQEAQAFIQQH----GKALA 920
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  134 QLQQKLAALSRQIDELEETNRSLRKAEEELQDIKekiskgeygnAGIMAeVEELRKRVLDMEGKDEEliKMEEQCRDLNK 213
Cdd:COG3096   921 QLEPLVAVLQSDPEQFEQLQADYLQAKEQQRRLK----------QQIFA-LSEVVQRRPHFSYEDAV--GLLGENSDLNE 987
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  214 RLERETLQSKdfklevEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESRLEK 293
Cdd:COG3096   988 KLRARLEQAE------EARREAREQLRQAQAQYSQYNQVLASLKSSRDAKQQTLQELEQELEELGVQADAEAEERARIRR 1061
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767925593  294 TEftLKEDLTKL--------KTLTVmFVDERKTMSEKLKKTEDKLQAASSqlQVEQNKV 344
Cdd:COG3096  1062 DE--LHEELSQNrsrrsqleKQLTR-CEAEMDSLQKRLRKAERDYKQERE--QVVQAKA 1115
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
133-388 1.36e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.59  E-value: 1.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  133 RQLQQKLAALSRQIDELEETNRSLRKAEEE---LQDIKEKisKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCR 209
Cdd:COG4913   221 PDTFEAADALVEHFDDLERAHEALEDAREQielLEPIREL--AERYAAARERLAELEYLRAALRLWFAQRRLELLEAELE 298
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  210 DLNKRLERETLQSKDFKLEVEKLSKRIMALEK-LEDAFNKSKQEcyslkcnLEKERmttKQLSQELESLKVRIKELEAIE 288
Cdd:COG4913   299 ELRAELARLEAELERLEARLDALREELDELEAqIRGNGGDRLEQ-------LEREI---ERLERELEERERRRARLEALL 368
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  289 SRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQnkvttvtEKLIEETKRALKSKTDVEEK 368
Cdd:COG4913   369 AALGLPLPASAEEFAALRAEAAALLEALEEELEALEEALAEAEAALRDLRREL-------RELEAEIASLERRKSNIPAR 441
                         250       260
                  ....*....|....*....|
gi 767925593  369 MYSVtkeRDDLKNKLKAEEE 388
Cdd:COG4913   442 LLAL---RDALAEALGLDEA 458
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
103-242 1.41e-03

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 41.93  E-value: 1.41e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   103 LEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKA-EEELQDIKEKISKGEYGNAGIM 181
Cdd:smart00787 145 LKEGLDENLEGLKEDYKLLMKELELLNSIKPKLRDRKDALEEELRQLKQLEDELEDCdPTELDRAKEKLKKLLQEIMIKV 224
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767925593   182 AEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKL-EVEKLSKRIMALEKL 242
Cdd:smart00787 225 KKLEELEEELQELESKIEDLTNKKSELNTEIAEAEKKLEQCRGFTFkEIEKLKEQLKLLQSL 286
DUF4407 pfam14362
Domain of unknown function (DUF4407); This family of proteins is found in bacteria. Proteins ...
104-245 2.59e-03

Domain of unknown function (DUF4407); This family of proteins is found in bacteria. Proteins in this family are typically between 366 and 597 amino acids in length. There is a single completely conserved residue R that may be functionally important.


Pssm-ID: 464151 [Multi-domain]  Cd Length: 295  Bit Score: 41.08  E-value: 2.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  104 EKELQTQ-TTKFHQDQDTIMAKLTNE-DSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKGEYGNAGI- 180
Cdd:pfam14362 105 EKEIDRElLEIQQEEADAAKAQLAAAyRARLAELEAQIAALDAEIDAAEARLDALQAEARCELDGTPGTGTGVPGDGPVa 184
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767925593  181 ---MAEVEELRKRVLDMEGK-DEELIKMEEQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDA 245
Cdd:pfam14362 185 ktkQAQLDAAQAELAALQAQnDARLAALRAELARLTAERAAARARSQAAIDGDDGLLARLEALNRLTTE 253
mukB PRK04863
chromosome partition protein MukB;
69-291 2.87e-03

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 41.48  E-value: 2.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   69 RQKIQELTTNAKETHTKLALAEARVQEEEQkATRLEKELQTQTTKfHQDQDTIMAKLTNEDSQnRQLQQKLAALSRQIDE 148
Cdd:PRK04863  448 QAKEQEATEELLSLEQKLSVAQAAHSQFEQ-AYQLVRKIAGEVSR-SEAWDVARELLRRLREQ-RHLAEQLQQLRMRLSE 524
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  149 LEETNRSLRKAEEELQDIKEKISKGeYGNAgimAEVEELRkrvldmEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLE 228
Cdd:PRK04863  525 LEQRLRQQQRAERLLAEFCKRLGKN-LDDE---DELEQLQ------EELEARLESLSESVSEARERRMALRQQLEQLQAR 594
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767925593  229 VEKLSKRIM-------ALEKLEDAFN---KSKQECYSLKCN-LEKERmttkQLSQELESLKVRIKELEAIESRL 291
Cdd:PRK04863  595 IQRLAARAPawlaaqdALARLREQSGeefEDSQDVTEYMQQlLERER----ELTVERDELAARKQALDEEIERL 664
PRK10246 PRK10246
exonuclease subunit SbcC; Provisional
56-292 2.90e-03

exonuclease subunit SbcC; Provisional


Pssm-ID: 182330 [Multi-domain]  Cd Length: 1047  Bit Score: 41.71  E-value: 2.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   56 DEQQRLTAQLTLQRQKIQELTTNAKEThtkLALAEARVQEEEQKATRLEKELQTQTTKFHQDQD------------TIMA 123
Cdd:PRK10246  297 ERIQEQSAALAHTRQQIEEVNTRLQST---MALRARIRHHAAKQSAELQAQQQSLNTWLAEHDRfrqwnnelagwrAQFS 373
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  124 KLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKaeeelQDIKEKISKgeygnagiMAEVEELRKRvldmegkdeeLIK 203
Cdd:PRK10246  374 QQTSDREQLRQWQQQLTHAEQKLNALPAITLTLTA-----DEVAAALAQ--------HAEQRPLRQR----------LVA 430
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  204 MEEQCRDLNKRLERetlqskdfkleveklskrimalekLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKV---- 279
Cdd:PRK10246  431 LHGQIVPQQKRLAQ------------------------LQVAIQNVTQEQTQRNAALNEMRQRYKEKTQQLADVKTiceq 486
                         250
                  ....*....|....*
gi 767925593  280 --RIKELEAIESRLE 292
Cdd:PRK10246  487 eaRIKDLEAQRAQLQ 501
46 PHA02562
endonuclease subunit; Provisional
298-536 2.93e-03

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 41.15  E-value: 2.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 298 LKEDLTKLKTLTVMfvderktmsEKLKKteDKLQAASSQLQVEQNKVTTVTEKL------IEETKRalKSKTDVEEKMYS 371
Cdd:PHA02562 155 LVEDLLDISVLSEM---------DKLNK--DKIRELNQQIQTLDMKIDHIQQQIktynknIEEQRK--KNGENIARKQNK 221
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 372 VTKERDDLKNkLKAEEEKGNDLLSRVNM------------------LKNRLQSLEAIEKDFLKNklnQDSGKSTTALHQE 433
Cdd:PHA02562 222 YDELVEEAKT-IKAEIEELTDELLNLVMdiedpsaalnklntaaakIKSKIEQFQKVIKMYEKG---GVCPTCTQQISEG 297
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 434 NNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEY--------------ETLERRYANERDKAQFLSKELEHVKMELAKY 499
Cdd:PHA02562 298 PDRITKIKDKLKELQHSLEKLDTAIDELEEIMDEFneqskkllelknkiSTNKQSLITLVDKAKKVKAAIEELQAEFVDN 377
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 767925593 500 KLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKE 536
Cdd:PHA02562 378 AEELAKLQDELDKIVKTKSELVKEKYHRGIVTDLLKD 414
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
122-512 2.99e-03

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 41.58  E-value: 2.99e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   122 MAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEE-LQDIKEKISKGEYGN--AGIMAE---VEELRKRVLD-- 193
Cdd:TIGR01612  485 IDENSKQDNTVKLILMRMKDFKDIIDFMELYKPDEVPSKNIiGFDIDQNIKAKLYKEieAGLKESyelAKNWKKLIHEik 564
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   194 --MEGKDEELIKMEEQCRDL-NKRLE--RETLQSKDFKLEVEklskrimalEKLEDAFNKSK--QECYSLKCNLEKERMT 266
Cdd:TIGR01612  565 keLEEENEDSIHLEKEIKDLfDKYLEidDEIIYINKLKLELK---------EKIKNISDKNEyiKKAIDLKKIIENNNAY 635
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   267 TKQLS-----QELESLKVRIKELEAIESRLEKTeftLKEDLTKLKTLTVMFVDErktmsEKLKKTEDK--LQAASSQLQV 339
Cdd:TIGR01612  636 IDELAkispyQVPEHLKNKDKIYSTIKSELSKI---YEDDIDALYNELSSIVKE-----NAIDNTEDKakLDDLKSKIDK 707
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   340 EQNKVTTVTEKLIE------ETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNrlqslEAIEKD 413
Cdd:TIGR01612  708 EYDKIQNMETATVElhlsniENKKNELLDIIVEIKKHIHGEINKDLNKILEDFKNKEKELSNKINDYAK-----EKDELN 782
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   414 FLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLerryanerdKAQFLSKELEHVK 493
Cdd:TIGR01612  783 KYKSKISEIKNHYNDQINIDNIKDEDAKQNYDKSKEYIKTISIKEDEIFKIINEMKFM---------KDDFLNKVDKFIN 853
                          410
                   ....*....|....*....
gi 767925593   494 MElakYKLAEKTETSHEQW 512
Cdd:TIGR01612  854 FE---NNCKEKIDSEHEQF 869
CagA_N pfam18971
CagA protein; The Helicobacter pylori type IV secretion effector CagA is a major bacterial ...
58-344 3.27e-03

CagA protein; The Helicobacter pylori type IV secretion effector CagA is a major bacterial virulence determinant and critical for gastric carcinogenesis. X-ray crystallographic analysis of the N-terminal CagA fragment (residues 1-876) revealed that the region has a structure comprised of three discrete domains. Domain I constitutes a mobile CagA N terminus, while Domain II tethers CagA to the plasma membrane by interacting with membrane phosphatidylserine. Domain III interacts intramolecularly with the intrinsically disordered C-terminal region, and this interaction potentiates the pathogenic scaffold/hub function of CagA.


Pssm-ID: 408741 [Multi-domain]  Cd Length: 876  Bit Score: 41.30  E-value: 3.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   58 QQRLTAQ-LTLQRQK--IQELTTNAKETHTKL-----ALAEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNED 129
Cdd:pfam18971 562 ENKLTAKgLSLQEANklIKDFLSSNKELAGKAlnfnkAVAEAKSTGNYDEVKKAQKDLEKSLRKREHLEKEVEKKLESKS 641
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  130 SQNRQLQQKLAALSrQIDEL-----EETNR---------SLRKAEEELQDIKEKISKgeygnagimaEVEELRKRVLDME 195
Cdd:pfam18971 642 GNKNKMEAKAQANS-QKDEIfalinKEANRdaraiaytqNLKGIKRELSDKLEKISK----------DLKDFSKSFDEFK 710
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  196 -GKDEELIKMEEQCRDLNKRLeretlqsKDFKLEVEKLSK---RIMALEKLEDAFNKSKQECYSLKCNLE---KERMTTK 268
Cdd:pfam18971 711 nGKNKDFSKAEETLKALKGSV-------KDLGINPEWISKvenLNAALNEFKNGKNKDFSKVTQAKSDLEnsvKDVIINQ 783
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767925593  269 QLSQELESLKVRIKELEAIE--SRLEKTeftlkedLTKLKTLTvmfvdeRKTMSEKLKKTEDKLQAASSQL-QVEQNKV 344
Cdd:pfam18971 784 KVTDKVDNLNQAVSVAKAMGdfSRVEQV-------LADLKNFS------KEQLAQQAQKNEDFNTGKNSELyQSVKNSV 849
RecN COG0497
DNA repair ATPase RecN [Replication, recombination and repair];
39-245 4.04e-03

DNA repair ATPase RecN [Replication, recombination and repair];


Pssm-ID: 440263 [Multi-domain]  Cd Length: 555  Bit Score: 40.83  E-value: 4.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  39 TLKEELTKLKSFALMVVDEQQRLTAQLT------LQRQKIQELTT------NAKETHTKLALAEARVQEEEQKATRLEKE 106
Cdd:COG0497  169 ALKKELEELRADEAERARELDLLRFQLEeleaaaLQPGEEEELEEerrrlsNAEKLREALQEALEALSGGEGGALDLLGQ 248
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 107 LQTQttkfhqdqdtiMAKLTNEDSQnrqLQQKLAALSRQIDELEETNRSLRKA-------EEELQDIKEKIS-----KGE 174
Cdd:COG0497  249 ALRA-----------LERLAEYDPS---LAELAERLESALIELEEAASELRRYldslefdPERLEEVEERLAllrrlARK 314
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767925593 175 YGN--AGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETlqskdfklevEKLSK-RIMALEKLEDA 245
Cdd:COG0497  315 YGVtvEELLAYAEELRAELAELENSDERLEELEAELAEAEAELLEAA----------EKLSAaRKKAAKKLEKA 378
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
321-538 4.09e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.52  E-value: 4.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 321 EKLKKTEDKLQAASSQLQVEQNKvttvTEKLIEETKRALKsktDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNML 400
Cdd:COG4942   23 AEAEAELEQLQQEIAELEKELAA----LKKEEKALLKQLA---ALERRIAALARRIRALEQELAALEAELAELEKEIAEL 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 401 KNRLQSLEAIEKDFLKN-KLNQDSGKSTTALHQENnkIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYANER 479
Cdd:COG4942   96 RAELEAQKEELAELLRAlYRLGRQPPLALLLSPED--FLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAER 173
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767925593 480 DKAQFLSKELEHVKMELAKYKlAEKTETSHEqwLFKRLQEEEAKSGHLSREVDALKEKI 538
Cdd:COG4942  174 AELEALLAELEEERAALEALK-AERQKLLAR--LEKELAELAAELAELQQEAEELEALI 229
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
59-164 4.27e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 40.77  E-value: 4.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  59 QRLTAQLTLQRQKIQELTTNAKETH-------TKLALAEARVQEEEQKA-TRLEKELQTQTTKFHQDQDTImAKLTNEDS 130
Cdd:COG3206  266 QQLRAQLAELEAELAELSARYTPNHpdvialrAQIAALRAQLQQEAQRIlASLEAELEALQAREASLQAQL-AQLEARLA 344
                         90       100       110
                 ....*....|....*....|....*....|....
gi 767925593 131 QNRQLQQKLAALSRQIDELEETNRSLRKAEEELQ 164
Cdd:COG3206  345 ELPELEAELRRLEREVEVARELYESLLQRLEEAR 378
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
436-587 5.29e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 40.82  E-value: 5.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   436 KIKELSQEVERL---KLKLKDMKAIEDDLMKTEdEYETLERRYANERDKAQfLSKELEHVKMELAKY--KLAEKTETSHE 510
Cdd:TIGR02169  192 IIDEKRQQLERLrreREKAERYQALLKEKREYE-GYELLKEKEALERQKEA-IERQLASLEEELEKLteEISELEKRLEE 269
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   511 qwLFKRLQEEEAKSGHL-SREVDALKEKIHEYMA----TEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELER 585
Cdd:TIGR02169  270 --IEQLLEELNKKIKDLgEEEQLRVKEKIGELEAeiasLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEE 347

                   ..
gi 767925593   586 YR 587
Cdd:TIGR02169  348 ER 349
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
184-481 5.31e-03

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 40.80  E-value: 5.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  184 VEELRKRVL----DMEGKDEELIKMEEqcrDLNKRLERETLQSKDFKLEVEK------LSKRI--MALEKLEdafnkskq 251
Cdd:PTZ00108 1037 VKELKKLGYvrfkDIIKKKSEKITAEE---EEGAEEDDEADDEDDEEELGAAvsydylLSMPIwsLTKEKVE-------- 1105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  252 ecyslkcNLEKERMTTKQLSQELESLKVR---IKELEAIESRLEKTEFTLKEDLTKLKTLTVM-FVDERKTMSEKLKKTE 327
Cdd:PTZ00108 1106 -------KLNAELEKKEKELEKLKNTTPKdmwLEDLDKFEEALEEQEEVEEKEIAKEQRLKSKtKGKASKLRKPKLKKKE 1178
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  328 DKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSL 407
Cdd:PTZ00108 1179 KKKKKSSADKSKKASVVGNSKRVDSDEKRKLDDKPDNKKSNSSGSDQEDDEEQKTKPKKSSVKRLKSKKNNSSKSSEDND 1258
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767925593  408 EAIEKDFLKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKD--MKAIEDDLMKTEDEYE--TLERRYANERDK 481
Cdd:PTZ00108 1259 EFSSDDLSKEGKPKNAPKRVSAVQYSPPPPSKRPDGESNGGSKPSSptKKKVKKRLEGSLAALKkkKKSEKKTARKKK 1336
CortBP2 pfam09727
Cortactin-binding protein-2; This entry is the first approximately 250 residues of ...
199-317 6.32e-03

Cortactin-binding protein-2; This entry is the first approximately 250 residues of cortactin-binding protein 2. In addition to being a positional candidate for autism this protein is expressed at highest levels in the brain in humans. The human protein has six associated ankyrin repeat domains pfam00023 towards the C-terminus which act as protein-protein interaction domains.


Pssm-ID: 462860 [Multi-domain]  Cd Length: 187  Bit Score: 38.74  E-value: 6.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  199 EELIKMEEQCRDLNKRLERETLqskdfklEVEKLSKRimALEKLEDafNKSKQECYSLK-----CNLEKERmttKQLSQE 273
Cdd:pfam09727  80 AELEKLVEKQRETQRRMLEQLA-------AAEKRHRR--VIRELEE--EKRKHARDTAQgddftYLLEKER---ERLKQE 145
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 767925593  274 LESLKVRIKELEAiesRLEKTEFTLKEDLTKLKTLTVMFVDERK 317
Cdd:pfam09727 146 LEQEKAQQKRLEK---ELKKLLEKLEEELSKQKQIALLLVKERK 186
HOOK pfam05622
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from ...
92-535 7.40e-03

HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organizms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas this central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head. This entry includes the central coiled-coiled domain and the divergent C-terminal domain.


Pssm-ID: 461694 [Multi-domain]  Cd Length: 528  Bit Score: 40.06  E-value: 7.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   92 RVQEEEQKATRLEKE---LQTQTTKFHQdqdtIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQdike 168
Cdd:pfam05622  15 RCHELDQQVSLLQEEknsLQQENKKLQE----RLDQLESGDDSGTPGGKKYLLLQKQLEQLQEENFRLETARDDYR---- 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  169 kiskgeygnagimAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLE--RETlQSKDFKLEVEKLSKRimalEKLEDAF 246
Cdd:pfam05622  87 -------------IKCEELEKEVLELQHRNEELTSLAEEAQALKDEMDilRES-SDKVKKLEATVETYK----KKLEDLG 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  247 NKSKQ---------ECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIES----RLEKTEFTLKEDLTKLKTLTV--- 310
Cdd:pfam05622 149 DLRRQvklleernaEYMQRTLQLEEELKKANALRGQLETYKRQVQELHGKLSeeskKADKLEFEYKKLEEKLEALQKeke 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  311 MFVDERKTmsekLKKTEDKLQAAssqlQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKG 390
Cdd:pfam05622 229 RLIIERDT----LRETNEELRCA----QLQQAELSQADALLSPSSDPGDNLAAEIMPAEIREKLIRLQHENKMLRLGQEG 300
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  391 ND---------LLSRVNMLKNRLQS-----------LEAIEKDFLKNKLNQ-----DSGKSTTALHQENNKIKELSQEVE 445
Cdd:pfam05622 301 SYrerltelqqLLEDANRRKNELETqnrlanqrileLQQQVEELQKALQEQgskaeDSSLLKQKLEEHLEKLHEAQSELQ 380
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  446 RLKLKLKD------------MKAIEDDLMKTEDEYETLERRYANERDKAQFLSKELEhvkmelAKYKLAEKTETsheQWL 513
Cdd:pfam05622 381 KKKEQIEElepkqdsnlaqkIDELQEALRKKDEDMKAMEERYKKYVEKAKSVIKTLD------PKQNPASPPEI---QAL 451
                         490       500
                  ....*....|....*....|..
gi 767925593  514 FKRLQEEEAKSGHLSREVDALK 535
Cdd:pfam05622 452 KNQLLEKDKKIEHLERDFEKSK 473
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
72-172 8.35e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 39.81  E-value: 8.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  72 IQELTTNAKETHTKLALAEARVQEeeqkATRLEKELQTQTTKFHQDQDTIMAKltnedsQNRQLQQKLAALSRQIDELEE 151
Cdd:PRK00409 522 IASLEELERELEQKAEEAEALLKE----AEKLKEELEEKKEKLQEEEDKLLEE------AEKEAQQAIKEAKKEADEIIK 591
                         90       100
                 ....*....|....*....|....*..
gi 767925593 152 TNRSLRK------AEEELQDIKEKISK 172
Cdd:PRK00409 592 ELRQLQKggyasvKAHELIEARKRLNK 618
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
319-483 8.49e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 39.43  E-value: 8.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 319 MSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGN------- 391
Cdd:COG3883   28 LQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERARALYRSGGsvsyldv 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 392 --------DLLSRVNMLK----NRLQSLEAIEKDflKNKLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIED 459
Cdd:COG3883  108 llgsesfsDFLDRLSALSkiadADADLLEELKAD--KAELEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLA 185
                        170       180
                 ....*....|....*....|....
gi 767925593 460 DLMKTEDEYETLERRYANERDKAQ 483
Cdd:COG3883  186 QLSAEEAAAEAQLAELEAELAAAE 209
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
36-252 8.66e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 39.90  E-value: 8.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   36 RVTTLKEELTKLKSfalmvvdEQQRLTAQLTLQRQKIQELttnakETHTKLALAEARVQEEEQKATRLEKELqtqttkfh 115
Cdd:COG4913   618 ELAELEEELAEAEE-------RLEALEAELDALQERREAL-----QRLAEYSWDEIDVASAEREIAELEAEL-------- 677
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  116 qdqdtimAKLTNEDSQNRQLQQKLAALSRQIDELEETnrsLRKAEEELQDIKEKIskgeygnAGIMAEVEELRKRVLDME 195
Cdd:COG4913   678 -------ERLDASSDDLAALEEQLEELEAELEELEEE---LDELKGEIGRLEKEL-------EQAEEELDELQDRLEAAE 740
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  196 --GKDEELIKMEEQCRDLNKRlERETLQSKDFKLEVEKLSKRIMALE-KLEDAFNKSKQE 252
Cdd:COG4913   741 dlARLELRALLEERFAAALGD-AVERELRENLEERIDALRARLNRAEeELERAMRAFNRE 799
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
1-361 9.25e-03

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 39.94  E-value: 9.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593    1 MFGCKKQDAEEQCLLKKLIDQeiksqeekEQEKEKRVTTLKEELtKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAK 80
Cdd:COG3096   294 LFGARRQLAEEQYRLVEMARE--------LEELSARESDLEQDY-QAASDHLNLVQTALRQQEKIERYQEDLEELTERLE 364
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593   81 ETHTKLALAEARVQEEEQKATRLE---KELQTQTTKFHQDQDTimakltnedSQNR--QLQQKLAALSR-----QIDELE 150
Cdd:COG3096   365 EQEEVVEEAAEQLAEAEARLEAAEeevDSLKSQLADYQQALDV---------QQTRaiQYQQAVQALEKaralcGLPDLT 435
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  151 ETNRSLRKAE---------EELQDIKEKIS-----KGEYGNA-----GIMAEVE---------ELRKRVLDMEGKDEELI 202
Cdd:COG3096   436 PENAEDYLAAfrakeqqatEEVLELEQKLSvadaaRRQFEKAyelvcKIAGEVErsqawqtarELLRRYRSQQALAQRLQ 515
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  203 KMEEQCRDLNKRLERetlQSKDFKLeVEKLSKRI----MALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLK 278
Cdd:COG3096   516 QLRAQLAELEQRLRQ---QQNAERL-LEEFCQRIgqqlDAAEELEELLAELEAQLEELEEQAAEAVEQRSELRQQLEQLR 591
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  279 VRIKELEAIESRLekteFTLKEDLTKLKTLTvmfvderktmSEKLKKTEDKLQAAssQLQVEQNKVTTVTEKLIEETKRA 358
Cdd:COG3096   592 ARIKELAARAPAW----LAAQDALERLREQS----------GEALADSQEVTAAM--QQLLEREREATVERDELAARKQA 655

                  ...
gi 767925593  359 LKS 361
Cdd:COG3096   656 LES 658
PRK09039 PRK09039
peptidoglycan -binding protein;
59-189 9.26e-03

peptidoglycan -binding protein;


Pssm-ID: 181619 [Multi-domain]  Cd Length: 343  Bit Score: 39.18  E-value: 9.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593  59 QRLTAQLTLQRQKIQELTTNAKETHTKLALAEA---RVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQL 135
Cdd:PRK09039  63 AELADLLSLERQGNQDLQDSVANLRASLSAAEAersRLQALLAELAGAGAAAEGRAGELAQELDSEKQVSARALAQVELL 142
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767925593 136 QQKLAALSRQIDELEEtnrSLRKAEEELQDIKEKISK-GEYGNAGIMAEVEELRK 189
Cdd:PRK09039 143 NQQIAALRRQLAALEA---ALDASEKRDRESQAKIADlGRRLNVALAQRVQELNR 194
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
128-483 9.95e-03

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 39.61  E-value: 9.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 128 EDSQNRQLQQKLAALSRQIdeLEETNRSLRKAEEEL-QDIKEKISkgeygnagimAEVEELRKRVLDMEGKDEELIKMEE 206
Cdd:NF033838  82 KHTQNVALNKKLSDIKTEY--LYELNVLKEKSEAELtSKTKKELD----------AAFEQFKKDTLEPGKKVAEATKKVE 149
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 207 QCRDLNKRLERE------TLQSKDFKLEVEKLSKRImalekledafNKSKQECYSLKCNLEKERMTTKQLSQELESLKVR 280
Cdd:NF033838 150 EAEKKAKDQKEEdrrnypTNTYKTLELEIAESDVEV----------KKAELELVKEEAKEPRDEEKIKQAKAKVESKKAE 219
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 281 IKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALK 360
Cdd:NF033838 220 ATRLEKIKTDREKAEEEAKRRADAKLKEAVEKNVATSEQDKPKRRAKRGVLGEPATPDKKENDAKSSDSSVGEETLPSPS 299
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925593 361 SKTdvEEKMYSVTKERDDLKNKLKAEEEKgndllSRVNMLKNRLQSL--EAIEKDFLKNKLNQDSGKSTTALHQENNKIK 438
Cdd:NF033838 300 LKP--EKKVAEAEKKVEEAKKKAKDQKEE-----DRRNYPTNTYKTLelEIAESDVKVKEAELELVKEEAKEPRNEEKIK 372
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 767925593 439 ELSQEVERLKLKLKDMKAIEDDLMKTEDEyetlERRYANERDKAQ 483
Cdd:NF033838 373 QAKAKVESKKAEATRLEKIKTDRKKAEEE----AKRKAAEEDKVK 413
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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