NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|767945341|ref|XP_011513630|]
View 

NPC1-like intracellular cholesterol transporter 1 isoform X3 [Homo sapiens]

Protein Classification

Niemann-Pick C type protein family( domain architecture ID 1003172)

Niemann-Pick C (NPC) type protein family is essential for sterol homeostasis that drive sterol integration into the lysosomal membrane before redistribution to other cellular membranes

Gene Ontology:  GO:0015485|GO:0030301

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
2A060601 super family cl36767
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
 71-719 0e+00

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00917:

Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 562.99  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341    71 QRSLEDEINRTTAEDLPIFATSYIVIFLYISLALGSYSSWSRVMVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLV 150
Cdd:TIGR00917  559 ERSIEDELKRESTADVITIAISYLVMFAYISLTLGDSPRLKSLYVTSKVLLGLSGILIVMLSVLGSVGVFSAVGLKSTLI 638

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341   151 ILQVVPFLVLSVGADNIFIFVLEYQRLPRRPGEPR---------EVHIGRALGRVAPSMLLCSLSEAICFFLGALTPMPA 221
Cdd:TIGR00917  639 IMEVIPFLVLAVGVDNIFILVFFYFYLEYFYRQVGvdneqeltlERRLSRALMEVGPSITLASLSEILAFALGALIKMPA 718

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341   222 VRTFALTSGLAVILDFLLQMSAFVALLSLDSKRQEASRLDVCCCVKPQELPPPGQG------EGLLLGFFQKAYAPFLLH 295
Cdd:TIGR00917  719 VRVFSMFAVLAVFLDFLLQITAFVALLVLDFKRTEDKRVDCFPCIKTSKSSISAEKgsgqrkAGLLTRYFKEVYAPVLLH 798

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341   296 WITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDYFLFLNRYFEVGAPVYFVTTLGYNFSSEAGMNAICSS 375
Cdd:TIGR00917  799 WIVKIVVIAFFVGLLMAGIALSTRVEIGLDQQIVLPQDSYLQIYFASLTPLLEVGPPFYIVIKGDYNYTDFESQNKLCTM 878

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341   376 AGCNNFSFTQkiqyatEFPEQSYLAIPASSWVDDFIDWLTP-SSCCRLYisgPNKDKFCPSTVNSlnCLKNCMSITMGSV 454
Cdd:TIGR00917  879 GGCDKDSIVN------VFNNLSYIAKPASSWLDDYLVWLSPqASCCCRK---FTNGTFCNGPDPQ--CFRCADLSSDAQG 947

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341   455 RPSVEQFHKYLPWFLNDRPNIKCPKGGLAAYSTSVNLT-SDGQVLASRFMAYHKPLKNSQDYTEALRAARELAANITADL 533
Cdd:TIGR00917  948 RPSTTQFKEKLPWFLNALPSADCAKGGHAAYSSAVDLQgYATIIQASSFRTYHTPLNTQVDFINAMRAAQEFAAKVSRSS 1027

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341   534 rkvpgtdpAFEVFPYTITNVFYEQYLTILPEGLFMLSLCLVPTFAVSCLLLGLDLRSGLLNLLSIVMILVDTVGFMALWG 613
Cdd:TIGR00917 1028 --------KMEVYPYSVFYVFFEQYLTIWKTAIINLSIALGAIFIVCLFLLQLNALSVVNLIMSVGMAVVFCVGIMHLWS 1099

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341   614 ISYNAVSLINLVSAVGMSVEFVSHITRSFAISTKPTWLERAKEATISMGSAVFAGVAMTNLPGILVLGLAKAQLIQIFFF 693
Cdd:TIGR00917 1100 ISLNAVSVVNSVMHKGIAIEFCTHINAQFSTGKHFSRNHRAKEALGGMGSSVFSGITLTKLVGVVVLGFSRSEIFVVYYF 1179

                          650       660
                   ....*....|....*....|....*.
gi 767945341   694 RLNLLITLLGLLHGLVFLPVILSYVG 719
Cdd:TIGR00917 1180 RMYLALVLLGFLHGLVFLPVLLSVLG 1205
 
Name Accession Description Interval E-value
2A060601 TIGR00917
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
 71-719 0e+00

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 562.99  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341    71 QRSLEDEINRTTAEDLPIFATSYIVIFLYISLALGSYSSWSRVMVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLV 150
Cdd:TIGR00917  559 ERSIEDELKRESTADVITIAISYLVMFAYISLTLGDSPRLKSLYVTSKVLLGLSGILIVMLSVLGSVGVFSAVGLKSTLI 638

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341   151 ILQVVPFLVLSVGADNIFIFVLEYQRLPRRPGEPR---------EVHIGRALGRVAPSMLLCSLSEAICFFLGALTPMPA 221
Cdd:TIGR00917  639 IMEVIPFLVLAVGVDNIFILVFFYFYLEYFYRQVGvdneqeltlERRLSRALMEVGPSITLASLSEILAFALGALIKMPA 718

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341   222 VRTFALTSGLAVILDFLLQMSAFVALLSLDSKRQEASRLDVCCCVKPQELPPPGQG------EGLLLGFFQKAYAPFLLH 295
Cdd:TIGR00917  719 VRVFSMFAVLAVFLDFLLQITAFVALLVLDFKRTEDKRVDCFPCIKTSKSSISAEKgsgqrkAGLLTRYFKEVYAPVLLH 798

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341   296 WITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDYFLFLNRYFEVGAPVYFVTTLGYNFSSEAGMNAICSS 375
Cdd:TIGR00917  799 WIVKIVVIAFFVGLLMAGIALSTRVEIGLDQQIVLPQDSYLQIYFASLTPLLEVGPPFYIVIKGDYNYTDFESQNKLCTM 878

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341   376 AGCNNFSFTQkiqyatEFPEQSYLAIPASSWVDDFIDWLTP-SSCCRLYisgPNKDKFCPSTVNSlnCLKNCMSITMGSV 454
Cdd:TIGR00917  879 GGCDKDSIVN------VFNNLSYIAKPASSWLDDYLVWLSPqASCCCRK---FTNGTFCNGPDPQ--CFRCADLSSDAQG 947

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341   455 RPSVEQFHKYLPWFLNDRPNIKCPKGGLAAYSTSVNLT-SDGQVLASRFMAYHKPLKNSQDYTEALRAARELAANITADL 533
Cdd:TIGR00917  948 RPSTTQFKEKLPWFLNALPSADCAKGGHAAYSSAVDLQgYATIIQASSFRTYHTPLNTQVDFINAMRAAQEFAAKVSRSS 1027

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341   534 rkvpgtdpAFEVFPYTITNVFYEQYLTILPEGLFMLSLCLVPTFAVSCLLLGLDLRSGLLNLLSIVMILVDTVGFMALWG 613
Cdd:TIGR00917 1028 --------KMEVYPYSVFYVFFEQYLTIWKTAIINLSIALGAIFIVCLFLLQLNALSVVNLIMSVGMAVVFCVGIMHLWS 1099

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341   614 ISYNAVSLINLVSAVGMSVEFVSHITRSFAISTKPTWLERAKEATISMGSAVFAGVAMTNLPGILVLGLAKAQLIQIFFF 693
Cdd:TIGR00917 1100 ISLNAVSVVNSVMHKGIAIEFCTHINAQFSTGKHFSRNHRAKEALGGMGSSVFSGITLTKLVGVVVLGFSRSEIFVVYYF 1179

                          650       660
                   ....*....|....*....|....*.
gi 767945341   694 RLNLLITLLGLLHGLVFLPVILSYVG 719
Cdd:TIGR00917 1180 RMYLALVLLGFLHGLVFLPVLLSVLG 1205
Sterol-sensing pfam12349
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ...
 114-267 1.72e-60

Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.


Pssm-ID: 463544 [Multi-domain]  Cd Length: 153  Bit Score: 200.89  E-value: 1.72e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341  114 MVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQVVPFLVLSVGADNIFIFVLEYQRLPRRPGEPRevHIGRAL 193
Cdd:pfam12349   1 MVKSKFGLGLAGVIIVLASVASSLGLCAYFGLPLTLIISEVIPFLVLAIGVDNIFLLVKAVVRTPRSLDVSE--RIAEAL 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767945341  194 GRVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSLDSKRQEASRLDVCCCVK 267
Cdd:pfam12349  79 GEVGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRRLESNRLDVACCIR 152
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
74-691 2.54e-16

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 83.37  E-value: 2.54e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341  74 LEDEINRTTAEDLPIF-ATSYIVIFLYISLALGSYSSWsrvmvdskatlgLGGVAVVLGAVMAAMGFFSYLGIRSSlVIL 152
Cdd:COG1033  208 LRGDIAEAIQSDLAIFfPLALLLILLLLFLFFRSLRGV------------LLPLLVVLLAVIWTLGLMGLLGIPLS-PLT 274

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341 153 QVVPFLVLSVGADNIFIFVLEYQRLpRRPGEPREVHIGRALGRVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSGLA 232
Cdd:COG1033  275 ILVPPLLLAIGIDYGIHLLNRYREE-RRKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIG 353

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341 233 VILDFLLQMSAFVALLSLDSKRQEASRldvcccvKPQELPPPGQGEGLLLGFFQKAYAPFLLhwitrgvvllLFLALFGV 312
Cdd:COG1033  354 VLLAFLTSLTLLPALLSLLPRPKPKTR-------RLKKPPELGRLLAKLARFVLRRPKVILV----------VALVLAVV 416

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341 313 SLYSMCHISVGLDQELALPKDSYLLDYFLFLNRYFEVGAPVYFVTTLGynfsseagmnaicSSAGCNNFSFTQKI----Q 388
Cdd:COG1033  417 SLYGISRLKVEYDFEDYLPEDSPIRQDLDFIEENFGGSDPLEVVVDTG-------------EPDGLKDPEVLKEIdrlqD 483

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341 389 YATEFPEqsylaIPASSWVDDFIDWLTpssccRLYISGPNKDKFCPSTVNSLNCLKNCMSITMGSVRPSVeqfhkylpwf 468
Cdd:COG1033  484 YLESLPE-----VGKVLSLADLVKELN-----QALNEGDPKYYALPESRELLAQLLLLLSSPPGDDLSRF---------- 543

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341 469 lndrpnikcpkgglaaystsvnLTSDGQvlASRFMAYHKPLKNSQdytealraarelAANITADLRKVPGTDPAFEVFPY 548
Cdd:COG1033  544 ----------------------VDEDYS--AARVTVRLKDLDSEE------------IKALVEEVRAFLAENFPPDGVEV 587

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341 549 TIT---NVFYEQYLTILPEGLFMLSLclvpTFAVSCLLLGLDLRS---GLLNLLSIVMILVDTVGFMALWGISYNAVSLI 622
Cdd:COG1033  588 TLTgsaVLFAAINESVIESQIRSLLL----ALLLIFLLLLLAFRSlrlGLISLIPNLLPILLTFGLMGLLGIPLNIATAV 663

                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767945341 623 NLVSAVGMSVE----FVSHITRsfAISTKPTWLERAKEATISMGSAVFaGVAMTNLPGILVLGLAKAQLIQIF 691
Cdd:COG1033  664 VASIALGIGVDytihFLSRYRE--ERRKGGDLEEAIRRALRTTGKAIL-FTSLTLAAGFGVLLFSSFPPLADF 733
 
Name Accession Description Interval E-value
2A060601 TIGR00917
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
 71-719 0e+00

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 562.99  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341    71 QRSLEDEINRTTAEDLPIFATSYIVIFLYISLALGSYSSWSRVMVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLV 150
Cdd:TIGR00917  559 ERSIEDELKRESTADVITIAISYLVMFAYISLTLGDSPRLKSLYVTSKVLLGLSGILIVMLSVLGSVGVFSAVGLKSTLI 638

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341   151 ILQVVPFLVLSVGADNIFIFVLEYQRLPRRPGEPR---------EVHIGRALGRVAPSMLLCSLSEAICFFLGALTPMPA 221
Cdd:TIGR00917  639 IMEVIPFLVLAVGVDNIFILVFFYFYLEYFYRQVGvdneqeltlERRLSRALMEVGPSITLASLSEILAFALGALIKMPA 718

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341   222 VRTFALTSGLAVILDFLLQMSAFVALLSLDSKRQEASRLDVCCCVKPQELPPPGQG------EGLLLGFFQKAYAPFLLH 295
Cdd:TIGR00917  719 VRVFSMFAVLAVFLDFLLQITAFVALLVLDFKRTEDKRVDCFPCIKTSKSSISAEKgsgqrkAGLLTRYFKEVYAPVLLH 798

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341   296 WITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDYFLFLNRYFEVGAPVYFVTTLGYNFSSEAGMNAICSS 375
Cdd:TIGR00917  799 WIVKIVVIAFFVGLLMAGIALSTRVEIGLDQQIVLPQDSYLQIYFASLTPLLEVGPPFYIVIKGDYNYTDFESQNKLCTM 878

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341   376 AGCNNFSFTQkiqyatEFPEQSYLAIPASSWVDDFIDWLTP-SSCCRLYisgPNKDKFCPSTVNSlnCLKNCMSITMGSV 454
Cdd:TIGR00917  879 GGCDKDSIVN------VFNNLSYIAKPASSWLDDYLVWLSPqASCCCRK---FTNGTFCNGPDPQ--CFRCADLSSDAQG 947

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341   455 RPSVEQFHKYLPWFLNDRPNIKCPKGGLAAYSTSVNLT-SDGQVLASRFMAYHKPLKNSQDYTEALRAARELAANITADL 533
Cdd:TIGR00917  948 RPSTTQFKEKLPWFLNALPSADCAKGGHAAYSSAVDLQgYATIIQASSFRTYHTPLNTQVDFINAMRAAQEFAAKVSRSS 1027

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341   534 rkvpgtdpAFEVFPYTITNVFYEQYLTILPEGLFMLSLCLVPTFAVSCLLLGLDLRSGLLNLLSIVMILVDTVGFMALWG 613
Cdd:TIGR00917 1028 --------KMEVYPYSVFYVFFEQYLTIWKTAIINLSIALGAIFIVCLFLLQLNALSVVNLIMSVGMAVVFCVGIMHLWS 1099

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341   614 ISYNAVSLINLVSAVGMSVEFVSHITRSFAISTKPTWLERAKEATISMGSAVFAGVAMTNLPGILVLGLAKAQLIQIFFF 693
Cdd:TIGR00917 1100 ISLNAVSVVNSVMHKGIAIEFCTHINAQFSTGKHFSRNHRAKEALGGMGSSVFSGITLTKLVGVVVLGFSRSEIFVVYYF 1179

                          650       660
                   ....*....|....*....|....*.
gi 767945341   694 RLNLLITLLGLLHGLVFLPVILSYVG 719
Cdd:TIGR00917 1180 RMYLALVLLGFLHGLVFLPVLLSVLG 1205
Sterol-sensing pfam12349
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ...
 114-267 1.72e-60

Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.


Pssm-ID: 463544 [Multi-domain]  Cd Length: 153  Bit Score: 200.89  E-value: 1.72e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341  114 MVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQVVPFLVLSVGADNIFIFVLEYQRLPRRPGEPRevHIGRAL 193
Cdd:pfam12349   1 MVKSKFGLGLAGVIIVLASVASSLGLCAYFGLPLTLIISEVIPFLVLAIGVDNIFLLVKAVVRTPRSLDVSE--RIAEAL 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767945341  194 GRVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSLDSKRQEASRLDVCCCVK 267
Cdd:pfam12349  79 GEVGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRRLESNRLDVACCIR 152
Patched pfam02460
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ...
 66-692 6.32e-54

Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.


Pssm-ID: 308203 [Multi-domain]  Cd Length: 793  Bit Score: 199.89  E-value: 6.32e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341   66 FSVLCQRSLEDEINRTTAEDLPIFATSYIVIFLYISLALGSYSSWSRVMVDSKATLGLGGVAVVLGAVMAAMGFFSYLGI 145
Cdd:pfam02460 196 FTIFHDQILNDELVRNALTLTPFFVIGFFLLLTFSIIVSVTLSSYTIDWVRSKPILAALGLLSPVMAIVSSFGLLFWMGF 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341  146 RSSlVILQVVPFLVLSVGADNIFIFVLEYQRLPRRPGEPREvhIGRALGRVAPSMLLCSLSEAICFFLGALTPMPAVRTF 225
Cdd:pfam02460 276 PFN-SIVCVTPFLVLAIGVDDMFLMVAAWQRTTATLSVKKR--MGEALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLF 352

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341  226 ALTSGLAVILDFLLQMSAFVALLSLDSKRQEASR--LDVCCCVKPQEL------PPPGQG-EGLLLGFFQKAYAPFLLHW 296
Cdd:pfam02460 353 CAYTAVAIFFDFIYQITFFAAIMAICAKPEAEGRhcLFVWATSSPQRIdsegsePDKSHNiEQLKSRFFLDIYCPFLLNP 432

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341  297 ITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDYFLFLNRYFevgapvyfvttlgynfsseagmnaicssa 376
Cdd:pfam02460 433 SVRVCMLVLFVVYIAIAIYGCVNIKEGLEPDKLVLEDSPLVEYLSLREKHF----------------------------- 483

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341  377 gcnnFSFTQKIQYATEFPEQsyLAIPAS-----SWVDDFIDwlTPssccrlYISGPNkdkfcpSTVNSLNCLKNCMSITM 451
Cdd:pfam02460 484 ----WPEGLQIQVAVNNPPN--LTIPESrdrmnEMVDEFEN--TP------YSLGPN------STLFWLREYENFLSTLN 543

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341  452 GSVRPSVEQFHKY--LPWFLndrpniKCPKGGLAAYSTSVNlTSDGQVLASRFMAYHKPLKNSQDYTEalraarelaanI 529
Cdd:pfam02460 544 MEEEEDEEKEWSYgnLPSFL------KAPGNSHWAGDLVWD-DNTTMVTKFRFTLAGKGLSTWNDRTR-----------A 605

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341  530 TADLRKVPGTDPAFEVFPYTITNVFYEQYLTILPEGLFMLSLCLVPTFAVsCLLLGLDLRSGLLNLLSIVMILVDTVGFM 609
Cdd:pfam02460 606 LQEWRSIADQYPEFNVTVFDEDAPFADQYLTILPSTIQNIVITLICMFIV-CFLFIPNPPCVFVITLAIASIDIGVFGFL 684

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341  610 ALWGISYNAVSLINLVSAVGMSVEFVSHITRSFAISTKPTWLERAKEATISMGSAVFAGvAMTNLPGILVLGLAKAQLIQ 689
Cdd:pfam02460 685 SLWGVDLDPISMITIIMSIGFSVDFSAHIAYHFVRSRGDTPAERVVDALEALGWPVFQG-GLSTILGVLVLLFVPSYMVV 763


                  ...
gi 767945341  690 IFF 692
Cdd:pfam02460 764 VFF 766
2A060602 TIGR00918
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
90-725 6.06e-36

The Eukaryotic (Putative) Sterol Transporter (EST) Family;


Pssm-ID: 273338 [Multi-domain]  Cd Length: 1145  Bit Score: 146.57  E-value: 6.06e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341    90 ATSYIVIFLYISLALGSYSSwsrvmVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQVVPFLVLSVGADNIFI 169
Cdd:TIGR00918  403 VSGYLLMLAYACLTMLRWDC-----AKSQGSVGLAGVLLVALSVAAGLGLCALLGISFNAATTQVLPFLALGVGVDDVFL 477

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341   170 FVLEY-QRLPRRPGEPRevhIGRALGRVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSGLAVILDFLLQMSAFVALL 248
Cdd:TIGR00918  478 LAHAFsETGQNIPFEER---TGECLKRTGASVVLTSISNVTAFFMAALIPIPALRAFSLQAAIVVVFNFAAVLLVFPAIL 554

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341   249 SLDSKRQEASRLDV-CCCVKP------QELP------------------------------------------------- 272
Cdd:TIGR00918  555 SLDLRRREDRRLDIfCCFFSPcsarviQIEPqayadgsappvysshmqstvqlrteydpgtqhyyttneprshlsvqpsd 634

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341   273 --------PPGQGEGL--------------------LLGFFQKAYAPFLLHWITRGVVLLLFLALFGVSLYSMCHISVGL 324
Cdd:TIGR00918  635 plscqspdIAGSTRDLlsqfedskaaclslpcarwtLATFAEKHYAPFLLQSWAKVVVIFLFLALLGLSLYGTTRVQDGL 714

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341   325 DQELALPKDSYLLDYFLFLNRYFEVgAPVYFVTTLGYNFSSeagmnaicssagcnnfsftqkIQYATEFPEQSYLAIPA- 403
Cdd:TIGR00918  715 DLTDIVPRDTNEHDFLDAQFRYFSF-YNMYAVTQGNFDYPT---------------------QQQLLYDLHQSFSSVKYv 772

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341   404 ---------SSWVDDFIDWL---------------TPSSCCR-----------LYISGPNKDKfcpsTVNSLNCLKNCMS 448
Cdd:TIGR00918  773 lkedngqlpRMWLHYFRDWLqglqkafdedwrdgrITKENYRngsddavlaykLLVQTGHRDK----PVDKEQLTTQRLV 848

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341   449 ITMGSVRPsvEQFHKYLP-WFLNDRPNIKCPKGGLAAY------------STSVNLTSDGQVLASRFMAYHKPLKNSQDY 515
Cdd:TIGR00918  849 NADGIINP--NAFYIYLSaWVSNDPVAYAASQANIYPHppewlhdkndydPENLRIPAAEPLEYAQFPFYLNGLRETSQF 926

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341   516 TEALRAARELAANITAdlRKVPGtdpafevFPYTITNVFYEQYLTILPEGLFMLSLCLVPTFAVSCLLLgLDLRSGLLNL 595
Cdd:TIGR00918  927 VEAIEHVRAICNNYEG--FGLPS-------YPSGYPFLFWEQYMGLRHWLLLSISVVLACTFLVCALLL-LNPWTAGLIV 996

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341   596 LSIVMILVDTVGFMALWGISYNAVSLINLVSAVGMSVEFVSHITRSFAISTKptwlERAKEATISMgSAVFAGV---AMT 672
Cdd:TIGR00918  997 LVLALMTVELFGMMGLLGIKLSAIPVVILIASVGIGVEFTVHIALGFLTAIG----DRNRRAVLAL-EHMFAPVldgALS 1071

                          730       740       750       760       770
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 767945341   673 NLPGILVLGLAKAQLIQIFFFRLNLLITLLGLLHGLVFLPVILSYVGP--DVNPA 725
Cdd:TIGR00918 1072 TLLGVLMLAGSEFDFIVRYFFAVLAVLTCLGVLNGLVLLPVLLSMFGPepEVSPA 1126
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
74-691 2.54e-16

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 83.37  E-value: 2.54e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341  74 LEDEINRTTAEDLPIF-ATSYIVIFLYISLALGSYSSWsrvmvdskatlgLGGVAVVLGAVMAAMGFFSYLGIRSSlVIL 152
Cdd:COG1033  208 LRGDIAEAIQSDLAIFfPLALLLILLLLFLFFRSLRGV------------LLPLLVVLLAVIWTLGLMGLLGIPLS-PLT 274

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341 153 QVVPFLVLSVGADNIFIFVLEYQRLpRRPGEPREVHIGRALGRVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSGLA 232
Cdd:COG1033  275 ILVPPLLLAIGIDYGIHLLNRYREE-RRKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIG 353

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341 233 VILDFLLQMSAFVALLSLDSKRQEASRldvcccvKPQELPPPGQGEGLLLGFFQKAYAPFLLhwitrgvvllLFLALFGV 312
Cdd:COG1033  354 VLLAFLTSLTLLPALLSLLPRPKPKTR-------RLKKPPELGRLLAKLARFVLRRPKVILV----------VALVLAVV 416

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341 313 SLYSMCHISVGLDQELALPKDSYLLDYFLFLNRYFEVGAPVYFVTTLGynfsseagmnaicSSAGCNNFSFTQKI----Q 388
Cdd:COG1033  417 SLYGISRLKVEYDFEDYLPEDSPIRQDLDFIEENFGGSDPLEVVVDTG-------------EPDGLKDPEVLKEIdrlqD 483

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341 389 YATEFPEqsylaIPASSWVDDFIDWLTpssccRLYISGPNKDKFCPSTVNSLNCLKNCMSITMGSVRPSVeqfhkylpwf 468
Cdd:COG1033  484 YLESLPE-----VGKVLSLADLVKELN-----QALNEGDPKYYALPESRELLAQLLLLLSSPPGDDLSRF---------- 543

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341 469 lndrpnikcpkgglaaystsvnLTSDGQvlASRFMAYHKPLKNSQdytealraarelAANITADLRKVPGTDPAFEVFPY 548
Cdd:COG1033  544 ----------------------VDEDYS--AARVTVRLKDLDSEE------------IKALVEEVRAFLAENFPPDGVEV 587

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341 549 TIT---NVFYEQYLTILPEGLFMLSLclvpTFAVSCLLLGLDLRS---GLLNLLSIVMILVDTVGFMALWGISYNAVSLI 622
Cdd:COG1033  588 TLTgsaVLFAAINESVIESQIRSLLL----ALLLIFLLLLLAFRSlrlGLISLIPNLLPILLTFGLMGLLGIPLNIATAV 663

                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767945341 623 NLVSAVGMSVE----FVSHITRsfAISTKPTWLERAKEATISMGSAVFaGVAMTNLPGILVLGLAKAQLIQIF 691
Cdd:COG1033  664 VASIALGIGVDytihFLSRYRE--ERRKGGDLEEAIRRALRTTGKAIL-FTSLTLAAGFGVLLFSSFPPLADF 733
MMPL pfam03176
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ...
 119-254 3.00e-06

MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.


Pssm-ID: 308676 [Multi-domain]  Cd Length: 332  Bit Score: 49.98  E-value: 3.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341  119 ATLGLGGVAVVLGAVMAAMGFFSY---LGIRSSLVILQVVpfLVLSVGAD-NIFIfVLEYQRlPRRPGEPREVHIGRALG 194
Cdd:pfam03176 169 ALLPLLTVGLSLGAAQGLVAILAHilgIGLSTFALNLLVV--LLIAVGTDyALFL-VSRYRE-ELRAGEDREEAVIRAVR 244

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341  195 RVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSLDSKR 254
Cdd:pfam03176 245 GTGKVVTAAGLTVAIAMLALSFARLPVFAQVGPTIAIGVLVDVLAALTLLPALLALLGRW 304
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
74-250 3.17e-06

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 50.63  E-value: 3.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341  74 LEDEINRTTAEDLP-IFATSYIVIFLYISLALGSYSswsrvmvdskatLGLGGVAVVLGAVMAAMGFFSYLGIRsslviL 152
Cdd:COG1033  595 LFAAINESVIESQIrSLLLALLLIFLLLLLAFRSLR------------LGLISLIPNLLPILLTFGLMGLLGIP-----L 657

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341 153 QVVPFLVLSV----GADNiFIFVLEYQRLPRRPGEPREVHIGRALGRVAPSMLLCSLSEAICFFLGALTPMPAVRTFALT 228
Cdd:COG1033  658 NIATAVVASIalgiGVDY-TIHFLSRYREERRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLL 736

                        170       180
                 ....*....|....*....|..
gi 767945341 229 SGLAVILDFLLQMSAFVALLSL 250
Cdd:COG1033  737 LALGLLVALLAALLLLPALLLL 758
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 72-271 5.53e-06

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 49.84  E-value: 5.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341   72 RSLEDEINRTTAedlpifatsyIVIFLYISLALGSYSSWSRvmvdskatlGLGGVAVVLGAVMAAMGFFSYLGIRSSLVI 151
Cdd:TIGR00921 189 REFGKDMGTTMA----------ISGILVVLVLLLDFKRWWR---------PLLPLVIILFGVAWVLGIMGWLGIPLYATT 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341  152 LQVVPfLVLSVGADNIFIFVLEYQRlprrpgeprEVHIGRALG--------RVAPSMLLCSLSEAICFFLGALTPMPAVR 223
Cdd:TIGR00921 250 LLAVP-MLIGVGIDYGIQTLNRYEE---------ERDIGRAKGeaivtavrRTGRAVLIALLTTSAGFAALALSEFPMVS 319

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 767945341  224 TFALTSGLAVILDFLLQMSAFVALL-SLDSKRQEASRLDVCCCVKPQEL 271
Cdd:TIGR00921 320 EFGLGLVAGLITAYLLTLLVLPALLqSIDIGREKVKKEIIAIGGKSSEI 368
COG4258 COG4258
Predicted exporter [General function prediction only];
14-239 9.26e-06

Predicted exporter [General function prediction only];


Pssm-ID: 443400 [Multi-domain]  Cd Length: 783  Bit Score: 49.08  E-value: 9.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341  14 HLLRPPQSGQYQSLRLLH--QQPPAVfpeqphAPAAHSQPDTDGADLPSRLEGPFSVLCQRSLEdeinrttaedlpIFAT 91
Cdd:COG4258  586 LLLLGRKDGQWAALVPLRgvDDAAAL------RAAAAGLPGVRLVDRKAESSSLFGRYRNDALW------------LLLL 647

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341  92 SYIVIFLYISLALGSyssWSRVmvdskatlgLGGVAVVLGAVMAAMGFFSYLGIRSSLVILqVVPFLVLSVGAD-NIFIf 170
Cdd:COG4258  648 ALLLILLLLLLRLRS---LRRA---------LRVLLPPLLAVLLTLAILGLLGIPLNLFHL-IALLLVLGIGIDyALFF- 713

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767945341 171 vleyQRLPRRPGEPRevhigralgRVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSGLAVILDFLL 239
Cdd:COG4258  714 ----TEGLLDKGELA---------RTLLSILLAALTTLLGFGLLAFSSTPALRSFGLTVLLGILLALLL 769
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 118-250 7.69e-05

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 46.37  E-value: 7.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341  118 KATLGLGGVAVVLGAVMAAMGFfsyLGIRSSLvILQVVPFLVLSVGADnIFIFVLEYQRLPRRPGEPREVhIGRALGRVA 197
Cdd:TIGR00921 593 KAVFPLIAIGSGILWAIGLMGL---RGIPSFL-AMATTISIILGLGMD-YSIHLAERYFEERKEHGPKEA-ITHTMERTG 666

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767945341  198 PSMLLCSLSEAICFFLGALTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSL 250
Cdd:TIGR00921 667 PGILFSGLTTAGGFLSLLLSHFPIMRNFGLVQGIGVLSSLTAALVVFPALLVL 719
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 582-692 9.32e-04

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 42.90  E-value: 9.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767945341  582 LLLGLDLRS---GLLNLLSIVMILVDTVGFMALWGISYNAVSLINLVSAVGMSVEFVSHITRSF------------AIST 646
Cdd:TIGR00921 208 LVLLLDFKRwwrPLLPLVIILFGVAWVLGIMGWLGIPLYATTLLAVPMLIGVGIDYGIQTLNRYeeerdigrakgeAIVT 287

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767945341  647 KPTWLERAKEATISMGSAVFAGVAMTNLPGI------LVLGLAKAQLIQIFF 692
Cdd:TIGR00921 288 AVRRTGRAVLIALLTTSAGFAALALSEFPMVsefglgLVAGLITAYLLTLLV 339
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH