mdm2-binding protein isoform X2 [Homo sapiens]
MTBP_N and MTBP_mid domain-containing protein( domain architecture ID 10633035)
MTBP_N and MTBP_mid domain-containing protein
List of domain hits
Name | Accession | Description | Interval | E-value | |||||
MTBP_N | pfam14918 | MDM2-binding; MTBP, or MDM2-binding protein, binds to MDM2. The MDM2 protein, through its ... |
1-270 | 9.84e-158 | |||||
MDM2-binding; MTBP, or MDM2-binding protein, binds to MDM2. The MDM2 protein, through its interaction with p53, plays an important role in the regulation of the G1 checkpoint of the cell cycle. MTBP promotes MDM2-mediated ubiquitination and degradation of p53 and also MDM2 stabilization in an MDM2 RING finger-dependent manner. MTBP differentially regulates the E3 ubiquitin ligase activity of MDM2 towards two of its most critical targets (itself and p53) and in doing so significantly contributes to MDM2-dependent p53 homeostasis in unstressed cells. MTBP inhibits cancer cell migration by interacting with a protein involved in cell motility. This motility protein is alpha-actinin-4 (ACTN4). It is unclear which regions of MTBP interact with which binding-partner. See PF14919, PF14920. : Pssm-ID: 464374 Cd Length: 254 Bit Score: 447.65 E-value: 9.84e-158
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MTBP_mid super family | cl20805 | MDM2-binding; MTBP, or MDM2-binding protein, binds to MDM2. The MDM2 protein, through its ... |
294-484 | 1.01e-128 | |||||
MDM2-binding; MTBP, or MDM2-binding protein, binds to MDM2. The MDM2 protein, through its interaction with p53, plays an important role in the regulation of the G1 checkpoint of the cell cycle. MTBP promotes MDM2-mediated ubiquitination and degradation of p53 and also MDM2 stabilization in an MDM2 RING finger-dependent manner. MTBP differentially regulates the E3 ubiquitin ligase activity of MDM2 towards two of its most critical targets (itself and p53) and in doing so significantly contributes to MDM2-dependent p53 homeostasis in unstressed cells. MTBP inhibits cancer cell migration by interacting with a protein involved in cell motility. This motility protein is alpha-actinin-4 (ACTN4). It is unclear which regions of MTBP interact with which binding-partner. See PF14918, PF14920. The actual alignment was detected with superfamily member pfam14919: Pssm-ID: 464375 Cd Length: 336 Bit Score: 377.05 E-value: 1.01e-128
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Name | Accession | Description | Interval | E-value | |||||
MTBP_N | pfam14918 | MDM2-binding; MTBP, or MDM2-binding protein, binds to MDM2. The MDM2 protein, through its ... |
1-270 | 9.84e-158 | |||||
MDM2-binding; MTBP, or MDM2-binding protein, binds to MDM2. The MDM2 protein, through its interaction with p53, plays an important role in the regulation of the G1 checkpoint of the cell cycle. MTBP promotes MDM2-mediated ubiquitination and degradation of p53 and also MDM2 stabilization in an MDM2 RING finger-dependent manner. MTBP differentially regulates the E3 ubiquitin ligase activity of MDM2 towards two of its most critical targets (itself and p53) and in doing so significantly contributes to MDM2-dependent p53 homeostasis in unstressed cells. MTBP inhibits cancer cell migration by interacting with a protein involved in cell motility. This motility protein is alpha-actinin-4 (ACTN4). It is unclear which regions of MTBP interact with which binding-partner. See PF14919, PF14920. Pssm-ID: 464374 Cd Length: 254 Bit Score: 447.65 E-value: 9.84e-158
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MTBP_mid | pfam14919 | MDM2-binding; MTBP, or MDM2-binding protein, binds to MDM2. The MDM2 protein, through its ... |
294-484 | 1.01e-128 | |||||
MDM2-binding; MTBP, or MDM2-binding protein, binds to MDM2. The MDM2 protein, through its interaction with p53, plays an important role in the regulation of the G1 checkpoint of the cell cycle. MTBP promotes MDM2-mediated ubiquitination and degradation of p53 and also MDM2 stabilization in an MDM2 RING finger-dependent manner. MTBP differentially regulates the E3 ubiquitin ligase activity of MDM2 towards two of its most critical targets (itself and p53) and in doing so significantly contributes to MDM2-dependent p53 homeostasis in unstressed cells. MTBP inhibits cancer cell migration by interacting with a protein involved in cell motility. This motility protein is alpha-actinin-4 (ACTN4). It is unclear which regions of MTBP interact with which binding-partner. See PF14918, PF14920. Pssm-ID: 464375 Cd Length: 336 Bit Score: 377.05 E-value: 1.01e-128
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Name | Accession | Description | Interval | E-value | |||||
MTBP_N | pfam14918 | MDM2-binding; MTBP, or MDM2-binding protein, binds to MDM2. The MDM2 protein, through its ... |
1-270 | 9.84e-158 | |||||
MDM2-binding; MTBP, or MDM2-binding protein, binds to MDM2. The MDM2 protein, through its interaction with p53, plays an important role in the regulation of the G1 checkpoint of the cell cycle. MTBP promotes MDM2-mediated ubiquitination and degradation of p53 and also MDM2 stabilization in an MDM2 RING finger-dependent manner. MTBP differentially regulates the E3 ubiquitin ligase activity of MDM2 towards two of its most critical targets (itself and p53) and in doing so significantly contributes to MDM2-dependent p53 homeostasis in unstressed cells. MTBP inhibits cancer cell migration by interacting with a protein involved in cell motility. This motility protein is alpha-actinin-4 (ACTN4). It is unclear which regions of MTBP interact with which binding-partner. See PF14919, PF14920. Pssm-ID: 464374 Cd Length: 254 Bit Score: 447.65 E-value: 9.84e-158
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MTBP_mid | pfam14919 | MDM2-binding; MTBP, or MDM2-binding protein, binds to MDM2. The MDM2 protein, through its ... |
294-484 | 1.01e-128 | |||||
MDM2-binding; MTBP, or MDM2-binding protein, binds to MDM2. The MDM2 protein, through its interaction with p53, plays an important role in the regulation of the G1 checkpoint of the cell cycle. MTBP promotes MDM2-mediated ubiquitination and degradation of p53 and also MDM2 stabilization in an MDM2 RING finger-dependent manner. MTBP differentially regulates the E3 ubiquitin ligase activity of MDM2 towards two of its most critical targets (itself and p53) and in doing so significantly contributes to MDM2-dependent p53 homeostasis in unstressed cells. MTBP inhibits cancer cell migration by interacting with a protein involved in cell motility. This motility protein is alpha-actinin-4 (ACTN4). It is unclear which regions of MTBP interact with which binding-partner. See PF14918, PF14920. Pssm-ID: 464375 Cd Length: 336 Bit Score: 377.05 E-value: 1.01e-128
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Blast search parameters | ||||
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