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Conserved domains on  [gi|767957709|ref|XP_011517091|]
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F-box/WD repeat-containing protein 5 isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
F-box_FBXW5 cd22132
F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, ...
 7-51 1.27e-21

F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, also called F-box and WD-40 domain-containing protein 5, is the substrate-recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438904 [Multi-domain]  Cd Length: 46  Bit Score: 87.67  E-value: 1.27e-21
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 767957709   7 PLLPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWREQFY 51
Cdd:cd22132    2 PLLPDSLLLHIFSYLSPKDLLAAGQVCKQWYRVSRDEFLWKELFY 46
WD40 COG2319
WD40 repeat [General function prediction only];
439-531 1.61e-09

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.92  E-value: 1.61e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957709 439 VFDLKTmREVRRALRAHR------AYTPNDEcffifldvsrdFVASGAEDRHGYIWDRHYNICLARLR-HEDVVNSVVFS 511
Cdd:COG2319  314 LWDLAT-GKLLRTLTGHTgavrsvAFSPDGK-----------TLASGSDDGTVRLWDLATGELLRTLTgHTGAVTSVAFS 381

                         90       100
                 ....*....|....*....|
gi 767957709 512 PQEQeLLLTASDDATIKAWR 531
Cdd:COG2319  382 PDGR-TLASGSADGTVRLWD 400
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 85-117 1.89e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


:

Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 1.89e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 767957709    85 VQTLREHTDQVLHLSFSHSGYQFASCSKDCTVK 117
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIK 37
 
Name Accession Description Interval E-value
F-box_FBXW5 cd22132
F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, ...
 7-51 1.27e-21

F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, also called F-box and WD-40 domain-containing protein 5, is the substrate-recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438904 [Multi-domain]  Cd Length: 46  Bit Score: 87.67  E-value: 1.27e-21
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 767957709   7 PLLPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWREQFY 51
Cdd:cd22132    2 PLLPDSLLLHIFSYLSPKDLLAAGQVCKQWYRVSRDEFLWKELFY 46
WD40 COG2319
WD40 repeat [General function prediction only];
439-531 1.61e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.92  E-value: 1.61e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957709 439 VFDLKTmREVRRALRAHR------AYTPNDEcffifldvsrdFVASGAEDRHGYIWDRHYNICLARLR-HEDVVNSVVFS 511
Cdd:COG2319  314 LWDLAT-GKLLRTLTGHTgavrsvAFSPDGK-----------TLASGSDDGTVRLWDLATGELLRTLTgHTGAVTSVAFS 381

                         90       100
                 ....*....|....*....|
gi 767957709 512 PQEQeLLLTASDDATIKAWR 531
Cdd:COG2319  382 PDGR-TLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 439-530 2.95e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.50  E-value: 2.95e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957709 439 VFDLKTmREVRRALRAHRAYtpndeCFFIFLDVSRDFVASGAEDRHGYIWDRHYNICLARLR-HEDVVNSVVFSPQEQEl 517
Cdd:cd00200  119 VWDVET-GKCLTTLRGHTDW-----VNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTgHTGEVNSVAFSPDGEK- 191

                         90
                 ....*....|...
gi 767957709 518 LLTASDDATIKAW 530
Cdd:cd00200  192 LLSSSSDGTIKLW 204
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 9-50 3.78e-09

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 52.49  E-value: 3.78e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 767957709    9 LPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWREQF 50
Cdd:pfam12937   4 LPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRLC 45
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 85-117 1.89e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 1.89e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 767957709    85 VQTLREHTDQVLHLSFSHSGYQFASCSKDCTVK 117
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIK 37
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 75-117 1.69e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.94  E-value: 1.69e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 767957709  75 RLYDTVPCVEVQTLREHTDQVLHLSFSHSGYQFASCSKDCTVK 117
Cdd:cd00200  160 KLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIK 202
WD40 pfam00400
WD domain, G-beta repeat;
85-117 4.67e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 4.67e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 767957709   85 VQTLREHTDQVLHLSFSHSGYQFASCSKDCTVK 117
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVK 36
FBOX smart00256
A Receptor for Ubiquitination Targets;
9-48 8.51e-05

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 40.11  E-value: 8.51e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767957709     9 LPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWRE 48
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFK 40
WD40 COG2319
WD40 repeat [General function prediction only];
75-117 4.96e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.59  E-value: 4.96e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 767957709  75 RLYDTVPCVEVQTLREHTDQVLHLSFSHSGYQFASCSKDCTVK 117
Cdd:COG2319  145 RLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVR 187
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 495-530 7.29e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 7.29e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 767957709   495 CLARLR-HEDVVNSVVFSPQEQeLLLTASDDATIKAW 530
Cdd:smart00320   4 LLKTLKgHTGPVTSVAFSPDGK-YLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
495-530 1.94e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 1.94e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 767957709  495 CLARLR-HEDVVNSVVFSPQEQeLLLTASDDATIKAW 530
Cdd:pfam00400   3 LLKTLEgHTGSVTSLAFSPDGK-LLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
F-box_FBXW5 cd22132
F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, ...
 7-51 1.27e-21

F-box domain found in F-box/WD repeat-containing protein 5 (FBXW5) and similar proteins; FBXW5, also called F-box and WD-40 domain-containing protein 5, is the substrate-recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438904 [Multi-domain]  Cd Length: 46  Bit Score: 87.67  E-value: 1.27e-21
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 767957709   7 PLLPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWREQFY 51
Cdd:cd22132    2 PLLPDSLLLHIFSYLSPKDLLAAGQVCKQWYRVSRDEFLWKELFY 46
WD40 COG2319
WD40 repeat [General function prediction only];
439-531 1.61e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.92  E-value: 1.61e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957709 439 VFDLKTmREVRRALRAHR------AYTPNDEcffifldvsrdFVASGAEDRHGYIWDRHYNICLARLR-HEDVVNSVVFS 511
Cdd:COG2319  314 LWDLAT-GKLLRTLTGHTgavrsvAFSPDGK-----------TLASGSDDGTVRLWDLATGELLRTLTgHTGAVTSVAFS 381

                         90       100
                 ....*....|....*....|
gi 767957709 512 PQEQeLLLTASDDATIKAWR 531
Cdd:COG2319  382 PDGR-TLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 439-530 2.95e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.50  E-value: 2.95e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957709 439 VFDLKTmREVRRALRAHRAYtpndeCFFIFLDVSRDFVASGAEDRHGYIWDRHYNICLARLR-HEDVVNSVVFSPQEQEl 517
Cdd:cd00200  119 VWDVET-GKCLTTLRGHTDW-----VNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTgHTGEVNSVAFSPDGEK- 191

                         90
                 ....*....|...
gi 767957709 518 LLTASDDATIKAW 530
Cdd:cd00200  192 LLSSSSDGTIKLW 204
WD40 COG2319
WD40 repeat [General function prediction only];
439-555 3.66e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.77  E-value: 3.66e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957709 439 VFDLKTMREVRRaLRAHRAYtpndecfFIFLDVSRD--FVASGAEDRHGYIWDRHYNICLARLR-HEDVVNSVVFSPQEQ 515
Cdd:COG2319  230 LWDLATGKLLRT-LTGHSGS-------VRSVAFSPDgrLLASGSADGTVRLWDLATGELLRTLTgHSGGVNSVAFSPDGK 301

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 767957709 516 eLLLTASDDATIKAW--RSPRTMRVLQAPRPRPRTF-FS----WLAS 555
Cdd:COG2319  302 -LLASGSDDGTVRLWdlATGKLLRTLTGHTGAVRSVaFSpdgkTLAS 347
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 9-50 3.78e-09

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 52.49  E-value: 3.78e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 767957709    9 LPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWREQF 50
Cdd:pfam12937   4 LPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRLC 45
WD40 COG2319
WD40 repeat [General function prediction only];
393-555 2.33e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 56.46  E-value: 2.33e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957709 393 IHGH---IIGMGLSPDNRYLYVNSRawpNGAVvadpmqpppiaeeidlLVFDLKTMREVRRaLRAHR------AYTPNDE 463
Cdd:COG2319  158 LTGHsgaVTSVAFSPDGKLLASGSD---DGTV----------------RLWDLATGKLLRT-LTGHTgavrsvAFSPDGK 217

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957709 464 cffifldvsrdFVASGAEDRHGYIWDRHYNICLARLR-HEDVVNSVVFSPQEQeLLLTASDDATIKAWR--SPRTMRVLQ 540
Cdd:COG2319  218 -----------LLASGSADGTVRLWDLATGKLLRTLTgHSGSVRSVAFSPDGR-LLASGSADGTVRLWDlaTGELLRTLT 285

                        170       180
                 ....*....|....*....|
gi 767957709 541 APRPRPRTF-FS----WLAS 555
Cdd:COG2319  286 GHSGGVNSVaFSpdgkLLAS 305
WD40 COG2319
WD40 repeat [General function prediction only];
420-555 1.48e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 53.76  E-value: 1.48e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957709 420 AVVADPMQPPPIAEEIDLLVFDLKTmREVRRALRAHRAYTPNdecffifLDVSRD--FVASGAEDRHGYIWDRHYNICLA 497
Cdd:COG2319   85 AFSPDGRLLASASADGTVRLWDLAT-GLLLRTLTGHTGAVRS-------VAFSPDgkTLASGSADGTVRLWDLATGKLLR 156

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767957709 498 RLR-HEDVVNSVVFSPQEQeLLLTASDDATIKAW--RSPRTMRVLQAPRPRPRTF-FS----WLAS 555
Cdd:COG2319  157 TLTgHSGAVTSVAFSPDGK-LLASGSDDGTVRLWdlATGKLLRTLTGHTGAVRSVaFSpdgkLLAS 221
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 439-531 5.55e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 51.57  E-value: 5.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957709 439 VFDLKTMREVRRaLRAHraytpNDECFFIFLDVSRDFVASGAEDRHGYIWDRHYNICLARLR-HEDVVNSVVFSPQEQeL 517
Cdd:cd00200  203 LWDLSTGKCLGT-LRGH-----ENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSgHTNSVTSLAWSPDGK-R 275

                         90
                 ....*....|....
gi 767957709 518 LLTASDDATIKAWR 531
Cdd:cd00200  276 LASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 449-530 7.97e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.80  E-value: 7.97e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957709 449 RRALRAHRaytpnDECFFIFLDVSRDFVASGAEDRHGYIWDRHYNICLARLR-HEDVVNSVVFSPQeQELLLTASDDATI 527
Cdd:cd00200    2 RRTLKGHT-----GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKgHTGPVRDVAASAD-GTYLASGSSDKTI 75


                 ...
gi 767957709 528 KAW 530
Cdd:cd00200   76 RLW 78
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 439-545 9.54e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.80  E-value: 9.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957709 439 VFDLKTMREVRRaLRAHraytpNDECFFIFLDVSRDFVASGAEDRHGYIWDRHYNICLARLR-HEDVVNSVVFSPQeQEL 517
Cdd:cd00200  161 LWDLRTGKCVAT-LTGH-----TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRgHENGVNSVAFSPD-GYL 233

                         90       100       110
                 ....*....|....*....|....*....|
gi 767957709 518 LLTASDDATIKAW--RSPRTMRVLQAPRPR 545
Cdd:cd00200  234 LASGSEDGTIRVWdlRTGECVQTLSGHTNS 263
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 85-117 1.89e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 1.89e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 767957709    85 VQTLREHTDQVLHLSFSHSGYQFASCSKDCTVK 117
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIK 37
F-box_AtGID2-like cd22151
F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, ...
 8-48 4.05e-06

F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, also called protein SLEEPY 1, is an essential component of the SCF-type E3 ligase complex, SCF(GID2), a complex that positively regulates the gibberellin signaling pathway. Upon gibberellin treatment, the SCF(GID2) complex mediates the ubiquitination and subsequent degradation of DELLA proteins (GAI, RGA and RGL2), some repressors of the gibberellin pathway, leading to the activation of the pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438922  Cd Length: 44  Bit Score: 43.85  E-value: 4.05e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 767957709   8 LLPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWRE 48
Cdd:cd22151    2 KLPDDLLQEIFKRLDPKSLARAACVCRRWRAAARSESLWEN 42
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 389-530 1.50e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.94  E-value: 1.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767957709 389 HVIDIHGHII-GMGLSPDNRYLYVNSRawpNGAVvadpmqpppiaeeidlLVFDLKTMREVRRaLRAHraytpNDECFFI 467
Cdd:cd00200    3 RTLKGHTGGVtCVAFSPDGKLLATGSG---DGTI----------------KVWDLETGELLRT-LKGH-----TGPVRDV 57

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767957709 468 FLDVSRDFVASGAEDRHGYIWDRHYNICLARLR-HEDVVNSVVFSPQEQeLLLTASDDATIKAW 530
Cdd:cd00200   58 AASADGTYLASGSSDKTIRLWDLETGECVRTLTgHTSYVSSVAFSPDGR-ILSSSSRDKTIKVW 120
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 75-117 1.69e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.94  E-value: 1.69e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 767957709  75 RLYDTVPCVEVQTLREHTDQVLHLSFSHSGYQFASCSKDCTVK 117
Cdd:cd00200  160 KLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIK 202
WD40 pfam00400
WD domain, G-beta repeat;
85-117 4.67e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 4.67e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 767957709   85 VQTLREHTDQVLHLSFSHSGYQFASCSKDCTVK 117
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVK 36
F-box_AtSKIP19-like cd22164
F-box domain found in Arabidopsis thaliana SKP1-interacting partner 19 (AtSKIP19) and similar ...
 9-47 6.06e-05

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 19 (AtSKIP19) and similar proteins; AtSKIP19, also called F-box protein SKIP19, or F-box/LRR-repeat protein 20 (FBL20), is a component of SCF (SPK1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with CUL1 and SPK1B/ASK2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438935 [Multi-domain]  Cd Length: 47  Bit Score: 40.66  E-value: 6.06e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 767957709   9 LPDSLVYQIFLSLGPADVLA-AGLVCRQWQAVSRDEFLWR 47
Cdd:cd22164    5 LPDDLTASILSRLGAIDILTnAQKVCKLWRRICKDPSMWR 44
FBOX smart00256
A Receptor for Ubiquitination Targets;
9-48 8.51e-05

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 40.11  E-value: 8.51e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767957709     9 LPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWRE 48
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFK 40
F-box_unchar cd22139
F-box domain found in uncharacterized F-box protein group similar to F-box only protein 3 ...
 7-47 8.75e-05

F-box domain found in uncharacterized F-box protein group similar to F-box only protein 3 (FBXO3); This subfamily corresponds to a group of uncharacterized F-box proteins which show sequence similarity to F-box only protein 3 (FBXO3). FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, that mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438911  Cd Length: 45  Bit Score: 39.92  E-value: 8.75e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 767957709   7 PLLPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWR 47
Cdd:cd22139    2 LCLPDELWLHIFSFLSPKDLCQVALVCRRFNRLASDESLWK 42
F-box_DdgacFF-like cd22148
F-box domain found in Dictyostelium discoideum Rho GTPase-activating protein gacFF (DdgacFF) ...
 8-48 1.01e-04

F-box domain found in Dictyostelium discoideum Rho GTPase-activating protein gacFF (DdgacFF) and similar proteins; DdgacFF, also called GTPase activating factor for raC protein FF, is a Rho GTPase-activating protein involved in the signal transduction pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438919  Cd Length: 44  Bit Score: 39.96  E-value: 1.01e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 767957709   8 LLPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWRE 48
Cdd:cd22148    4 LLPEHLALKILSYLSPKELLIASQVSKTWRRLASSNELWKA 44
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 9-41 1.15e-04

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 39.35  E-value: 1.15e-04
                         10        20        30
                 ....*....|....*....|....*....|...
gi 767957709   9 LPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSR 41
Cdd:cd09917    3 LPDEILLKILSYLDPRDLLRLSLVCKRWRELAS 35
F-box_FBXL1 cd22114
F-box domain found in F-box/LRR-repeat protein 1 (FBXL1) and similar proteins; FBXL1, also ...
 9-46 1.56e-04

F-box domain found in F-box/LRR-repeat protein 1 (FBXL1) and similar proteins; FBXL1, also called S-phase kinase-associated protein 2, cyclin-A/CDK2-associated protein p45, F-box protein Skp2, or p45skp2, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. It specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438886  Cd Length: 41  Bit Score: 39.32  E-value: 1.56e-04
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 767957709   9 LPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLW 46
Cdd:cd22114    4 LPDELLLGIFSCLCLPDLLKVSQVCKRWYRLASDESLW 41
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 75-117 1.62e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.86  E-value: 1.62e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 767957709  75 RLYDTVPCVEVQTLREHTDQVLHLSFSHSGYQFASCSKDCTVK 117
Cdd:cd00200  202 KLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIR 244
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 75-117 1.68e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.86  E-value: 1.68e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 767957709  75 RLYDTVPCVEVQTLREHTDQVLHLSFSHSGYQFASCSKDCTVK 117
Cdd:cd00200  118 KVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160
F-box_FBXO41 cd22109
F-box domain found in F-box only protein 41 (FBXO41) and similar proteins; FBXO41, also called ...
 7-48 1.81e-04

F-box domain found in F-box only protein 41 (FBXO41) and similar proteins; FBXO41, also called FBX41, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a novel central nervous system (CNS)-specific F-box protein that localizes to the centrosome and the cytoplasm of neurons and promotes neuronal migration. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438881  Cd Length: 47  Bit Score: 39.23  E-value: 1.81e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 767957709   7 PLLPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWRE 48
Cdd:cd22109    4 SLRRRDALFCVFSYLDTKSLLRCAEVCREWRDVSRHPALWQR 45
F-box_FBXL12 cd22123
F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also ...
 9-47 2.09e-04

F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also called F-box and leucine-rich repeat protein 12, or F-box protein FBL12, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the polyubiquitination and proteasomal degradation of calcium/calmodulin dependent protein kinase I (CAMK1) leading to disruption of cyclin D1/CDK4 complex assembly, which results in G1 cell cycle arrest in lung epithelia. It regulates T-cell differentiation in a cell-autonomous manner. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438895  Cd Length: 42  Bit Score: 38.87  E-value: 2.09e-04
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 767957709   9 LPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWR 47
Cdd:cd22123    4 LPENVLLEILSYLPVRDLLRISRVCKRWRRLVYDKTLWR 42
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 75-117 2.31e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.48  E-value: 2.31e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 767957709  75 RLYDTVPCVEVQTLREHTDQVLHLSFSHSGYQFASCSKDCTVK 117
Cdd:cd00200  244 RVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIR 286
F-box_FBXW12 cd22137
F-box domain found in F-box/WD repeat-containing protein 12 (FBXW12) and similar proteins; ...
 9-47 2.53e-04

F-box domain found in F-box/WD repeat-containing protein 12 (FBXW12) and similar proteins; FBXW12, also called F-box and WD-40 domain-containing protein 12, or F-box only protein 35 (FBXO35), is the substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It functions as an epithelial growth suppressor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438909  Cd Length: 44  Bit Score: 38.90  E-value: 2.53e-04
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 767957709   9 LPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWR 47
Cdd:cd22137    3 LPDLPMLRIFSFLDAFSLLQAAQVNKQWNKVADSDYLWR 41
F-box_AtARP8-like cd22156
F-box domain found in Arabidopsis thaliana actin-related protein 8 (AtARP8) and similar ...
 9-46 3.66e-04

F-box domain found in Arabidopsis thaliana actin-related protein 8 (AtARP8) and similar proteins; AtARP8, also called F-box protein ARP8, is an F-box protein localized to the nucleolus in Arabidopsis. Unlike other plant nuclear actin-related proteins (ARPs), ARP8 is unique in having an F-box domain and an actin homology domain. It may play a role in nucleolar functions. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438927  Cd Length: 45  Bit Score: 38.51  E-value: 3.66e-04
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 767957709   9 LPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLW 46
Cdd:cd22156    5 LPEDVLMQILRLLGPKDAAKLCLVCKSWRYLVSDNRLW 42
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 9-47 3.85e-04

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 38.29  E-value: 3.85e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 767957709    9 LPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWR 47
Cdd:pfam00646   4 LPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWK 42
WD40 COG2319
WD40 repeat [General function prediction only];
75-117 4.96e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.59  E-value: 4.96e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 767957709  75 RLYDTVPCVEVQTLREHTDQVLHLSFSHSGYQFASCSKDCTVK 117
Cdd:COG2319  145 RLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVR 187
F-box_FBXL13 cd22124
F-box domain found in F-box/LRR-repeat protein 13 (FBXL13) and similar proteins; FBXL13, also ...
 8-46 7.01e-04

F-box domain found in F-box/LRR-repeat protein 13 (FBXL13) and similar proteins; FBXL13, also called F-box and leucine-rich repeat protein 13, or dynein regulatory complex subunit 6, is a component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. It is also the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438896  Cd Length: 42  Bit Score: 37.31  E-value: 7.01e-04
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 767957709   8 LLPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLW 46
Cdd:cd22124    3 LLPRKAALKIFSYLDLRDLARCAQVCRSWKVITQSSSLW 41
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 495-530 7.29e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 7.29e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 767957709   495 CLARLR-HEDVVNSVVFSPQEQeLLLTASDDATIKAW 530
Cdd:smart00320   4 LLKTLKgHTGPVTSVAFSPDGK-YLASGSDDGTIKLW 39
WD40 COG2319
WD40 repeat [General function prediction only];
75-117 1.16e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.44  E-value: 1.16e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 767957709  75 RLYDTVPCVEVQTLREHTDQVLHLSFSHSGYQFASCSKDCTVK 117
Cdd:COG2319  229 RLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVR 271
F-box_FBXL5 cd22118
F-box domain found in F-box/LRR-repeat protein 5 (FBXL5) and similar proteins; FBXL5, also ...
 9-46 1.56e-03

F-box domain found in F-box/LRR-repeat protein 5 (FBXL5) and similar proteins; FBXL5, also called F-box and leucine-rich repeat protein 5, F-box protein FBL4/FBL5, or p45SKP2-like protein, is the substrate-recognition component of an SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438890  Cd Length: 41  Bit Score: 36.55  E-value: 1.56e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 767957709   9 LPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLW 46
Cdd:cd22118    4 LPPEIMLKIFSYLNPQDLCRCAQVCTKWSQLARDGSLW 41
F-box_FBXO33 cd22104
F-box domain found in F-box only protein 33 (FBXO33) and similar proteins; FBXO33, also called ...
 9-48 1.63e-03

F-box domain found in F-box only protein 33 (FBXO33) and similar proteins; FBXO33, also called FBX33, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It exerts similar functions as F-box involved in polyQ pathogenesis (FipoQ) in modulating the ubiquitination and solubility of expanded SCA3-polyQ proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438876  Cd Length: 48  Bit Score: 36.46  E-value: 1.63e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 767957709   9 LPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWRE 48
Cdd:cd22104    4 LPSVVLVHIFSYLPPRDRLRASSTCRRWREALFHPSLWRS 43
WD40 COG2319
WD40 repeat [General function prediction only];
75-117 1.72e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.05  E-value: 1.72e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 767957709  75 RLYDTVPCVEVQTLREHTDQVLHLSFSHSGYQFASCSKDCTVK 117
Cdd:COG2319  355 RLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVR 397
WD40 pfam00400
WD domain, G-beta repeat;
495-530 1.94e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 1.94e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 767957709  495 CLARLR-HEDVVNSVVFSPQEQeLLLTASDDATIKAW 530
Cdd:pfam00400   3 LLKTLEgHTGSVTSLAFSPDGK-LLASGSDDGTVKVW 38
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 75-117 2.23e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.40  E-value: 2.23e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 767957709  75 RLYDTVPCVEVQTLREHTDQVLHLSFSHSGYQFASCSKDCTVK 117
Cdd:cd00200   76 RLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIK 118
F-box_DmSKP2-like cd22149
F-box domain found in Drosophila melanogaster S-phase kinase-associated protein 2 (DmSKP2) and ...
 9-47 2.25e-03

F-box domain found in Drosophila melanogaster S-phase kinase-associated protein 2 (DmSKP2) and similar proteins; DmSKP2 is a Drosophila F-box protein that regulates cell proliferation by targeting Dacapo (Dap) for ubiquitination and proteasome-mediated degradation. It plays a role in maintaining diploidy of mitotic cells during development. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438920  Cd Length: 43  Bit Score: 36.20  E-value: 2.25e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 767957709   9 LPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWR 47
Cdd:cd22149    4 LSDEIILSIFKWLPKKTLARCARVCRRWKRLCFDESLWR 42
WD40 COG2319
WD40 repeat [General function prediction only];
75-117 3.03e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 40.28  E-value: 3.03e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 767957709  75 RLYDTVPCVEVQTLREHTDQVLHLSFSHSGYQFASCSKDCTVK 117
Cdd:COG2319  187 RLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVR 229
F-box_FBXW8 cd22134
F-box domain found in F-box/WD repeat-containing protein 8 (FBXW8) and similar proteins; FBXW8, ...
 9-46 3.47e-03

F-box domain found in F-box/WD repeat-containing protein 8 (FBXW8) and similar proteins; FBXW8, also called F-box and WD-40 domain-containing protein 8, or F-box only protein 29 (FBXO29), is the substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as GORASP1, IRS1, MAP4K1/HPK1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438906  Cd Length: 48  Bit Score: 35.82  E-value: 3.47e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 767957709   9 LPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLW 46
Cdd:cd22134    7 LPRELALKIFQYLSVTDLCRCAQVSKSWKSLAEDELLW 44
F-box_FBXO4 cd22085
F-box domain found in F-box only protein 4 (FBXO4) and similar proteins; FBXO4, also called ...
 9-47 3.52e-03

F-box domain found in F-box only protein 4 (FBXO4) and similar proteins; FBXO4, also called FBX4, is a specific substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that catalyzes the ubiquitination and subsequent degradation of cyclin D1 and Trx1. It recognizes TERF1 and promotes its ubiquitination together with UBE2D1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438857  Cd Length: 50  Bit Score: 35.85  E-value: 3.52e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 767957709   9 LPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWR 47
Cdd:cd22085    6 LPIDLQLYILSFLSPHDLCQLGLTSHYWHTLVRDPLLWR 44
F-box_SpPof1-like cd22147
F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar ...
 8-50 3.56e-03

F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar proteins; SpPof1, also called F-box/WD repeat-containing protein pof1, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is required for the inactivation of zip1 via ubiquitination. This subfamily also includes Saccharomyces cerevisiae methionine-requiring protein 30 (ScMET30, also called E3 ubiquitin ligase complex SCF(Met30) subunit MET30), Aspergillus niger sulfur controller B (AnSCONB, also called sulfur metabolite repression control protein B) and Neurospora crassa sulfur controller 2 (NcSCON2, also called sulfur metabolite repression control protein 2). ScMET30 acts as a transcriptional inhibitor that negatively regulates the expression of sulfur amino acid biosynthesis genes. It controls cell cycle function (being required for the G1/S transition and M-phase but not the S-phase), sulfur metabolism, and methionine biosynthesis as part of the E3 ubiquitin ligase complex SCF(Met30). AnSCONB and NcSCON2 are components of the SCF (sconB/scon-2) E3 ubiquitin ligase complexes involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438918  Cd Length: 46  Bit Score: 35.75  E-value: 3.56e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 767957709   8 LLPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWREQF 50
Cdd:cd22147    4 ALPVELSLKILSYLDAKSLCRAAQVSKKWRNLADDDELWKRMC 46
WD40 COG2319
WD40 repeat [General function prediction only];
75-117 6.19e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 39.12  E-value: 6.19e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 767957709  75 RLYDTVPCVEVQTLREHTDQVLHLSFSHSGYQFASCSKDCTVK 117
Cdd:COG2319  271 RLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVR 313
F-box_FBXO13 cd22092
F-box domain found in F-box only protein 13 (FBXO13) and similar proteins; FBXO13, also called ...
 8-48 7.01e-03

F-box domain found in F-box only protein 13 (FBXO13) and similar proteins; FBXO13, also called FBX13, F-box/LRR-repeat protein 17 (FBL17), or F-box and leucine-rich repeat protein 17 (FBXL17), is the substrate-recognition component of SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438864  Cd Length: 49  Bit Score: 34.70  E-value: 7.01e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 767957709   8 LLPDSLVYQIFLSLGPAD-VLAAGLVCRQWQAVSRDEFLWRE 48
Cdd:cd22092    4 QLPDSILLKIFSYLSLQErCLSASLVCKYWRDLCLDSQFWKQ 45
F-box_FBXW7 cd22133
F-box domain found in F-box/WD repeat-containing protein 7 (FBXW7) and similar proteins; FBXW7, ...
 8-47 8.49e-03

F-box domain found in F-box/WD repeat-containing protein 7 (FBXW7) and similar proteins; FBXW7, also called Archipelago homolog (Ago), F-box and WD-40 domain-containing protein 7, F-box protein FBX30, SEL-10, or Cdc4, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, and probably PSEN1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438905  Cd Length: 59  Bit Score: 35.09  E-value: 8.49e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 767957709   8 LLPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWR 47
Cdd:cd22133   20 LLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWR 59
F-box_FBXO21 cd22096
F-box domain found in F-box only protein 21 (FBXO21) and similar proteins; FBXO21, also called ...
 7-50 8.60e-03

F-box domain found in F-box only protein 21 (FBXO21) and similar proteins; FBXO21, also called FBX21, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It facilitates Lys29-linkage and activation of ASK1 (apoptosis signal-regulating kinase 1) and promotes type I interferon production upon viral infection. It also polyubiquitylates EP300-interacting inhibitor of differentiation 1 (EID1) and is required for the efficient degradation of EID1 in both cycling and quiescent cells. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438868  Cd Length: 48  Bit Score: 34.59  E-value: 8.60e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 767957709   7 PLLPDSLVYQIFLS--LGPADVLAAGLVCRQWQAVSRDEFLWREQF 50
Cdd:cd22096    2 LELPDELLEYILCSdnLDHHDIIRLSCTCRRLREVCQSGKVWREKF 47
F-box_FBXO11 cd22091
F-box domain found in F-box only protein 11 (FBXO11) and similar proteins; FBXO11, also called ...
 9-47 9.73e-03

F-box domain found in F-box only protein 11 (FBXO11) and similar proteins; FBXO11, also called FBX11, protein arginine N-methyltransferase 9 (PRMT9), or vitiligo-associated protein 1 (VIT-1), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438863  Cd Length: 45  Bit Score: 34.32  E-value: 9.73e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 767957709   9 LPDSLVYQIFLSLGPADVLAAGLVCRQWQAVSRDEFLWR 47
Cdd:cd22091    4 LPDEVLLKIFSYLLEQDLCRAAQVCKRFNTLANDPELWK 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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