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Conserved domains on  [gi|767986955|ref|XP_011520693|]
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BICD family-like cargo adapter 2 isoform X2 [Homo sapiens]

Protein Classification

coiled-coil domain-containing protein( domain architecture ID 1000037)

coiled-coil domain-containing protein contains a region with alpha-helical coiled-coil sequence signatures that is being annotated by a variety of protein family models, not necessarily indicating family membership

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Smc super family cl34174
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 26-420 1.38e-12

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG1196:

Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 69.97  E-value: 1.38e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955  26 QQLERLQQENHELRRGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQASQT 105
Cdd:COG1196  298 ARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEA 377

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955 106 EQELQRELDALrgqcQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHeellllrrerre 185
Cdd:COG1196  378 EEELEELAEEL----LEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEE------------ 441

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955 186 hsLELERARSEAGEALSALRRLQRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKAS 265
Cdd:COG1196  442 --EALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGL 519

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955 266 SPQPSP-PEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQS-------LREELQRQKELRAQEDPGEALHS 337
Cdd:COG1196  520 RGLAGAvAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAkagratfLPLDKIRARAALAAALARGAIGA 599

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955 338 ALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQELEAWQDDMQVVIGQQLRSQRQKELSASASSSTPR 417
Cdd:COG1196  600 AVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEA 679


                 ...
gi 767986955 418 RAA 420
Cdd:COG1196  680 ELE 682
 
Name Accession Description Interval E-value
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 26-420 1.38e-12

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 69.97  E-value: 1.38e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955  26 QQLERLQQENHELRRGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQASQT 105
Cdd:COG1196  298 ARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEA 377

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955 106 EQELQRELDALrgqcQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHeellllrrerre 185
Cdd:COG1196  378 EEELEELAEEL----LEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEE------------ 441

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955 186 hsLELERARSEAGEALSALRRLQRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKAS 265
Cdd:COG1196  442 --EALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGL 519

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955 266 SPQPSP-PEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQS-------LREELQRQKELRAQEDPGEALHS 337
Cdd:COG1196  520 RGLAGAvAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAkagratfLPLDKIRARAALAAALARGAIGA 599

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955 338 ALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQELEAWQDDMQVVIGQQLRSQRQKELSASASSSTPR 417
Cdd:COG1196  600 AVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEA 679


                 ...
gi 767986955 418 RAA 420
Cdd:COG1196  680 ELE 682
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 20-231 4.44e-10

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 62.00  E-value: 4.44e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955    20 QVQKPRQQLERLQQENHELRRGLAARGAE---WEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLS 96
Cdd:TIGR02168  713 ELEQLRKELEELSRQISALRKDLARLEAEveqLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIE 792

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955    97 QQLAQASQTEQ---ELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTH 173
Cdd:TIGR02168  793 QLKEELKALREaldELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELE 872

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 767986955   174 EELLLLRRERREHSLELERARSEAGEALSALRRLQRRVSELEEESRLQDADVSAASLQ 231
Cdd:TIGR02168  873 SELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELR 930
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
29-392 1.37e-05

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 47.73  E-value: 1.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955  29 ERLQQENHELRRGLAARGAEWEARAVELEGDVEALRAQLGEQrSEQQDSGRERARALSELSEQNLRLSQQLAQASQTEQE 108
Cdd:PRK02224 198 EKEEKDLHERLNGLESELAELDEEIERYEEQREQARETRDEA-DEVLEEHEERREELETLEAEIEDLRETIAETEREREE 276

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955 109 LQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSL 188
Cdd:PRK02224 277 LAEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDRLEECRVAAQAHNEEAESLREDADDLEE 356

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955 189 ELERARSEAGE-------ALSALRRLQRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSpkT 261
Cdd:PRK02224 357 RAEELREEAAEleseleeAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREERDELREREAELEA--T 434

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955 262 RKASSPQPSPPEEILEPPKKRTSLSP------AEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKELRAQEDPGEal 335
Cdd:PRK02224 435 LRTARERVEEAEALLEAGKCPECGQPvegsphVETIEEDRERVEELEAELEDLEEEVEEVEERLERAEDLVEAEDRIE-- 512

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767986955 336 hsALSDRDEAVNKALElslqLNRVSLERDSLSRELLRAirQKVALTQELEAWQDDMQ 392
Cdd:PRK02224 513 --RLEERREDLEELIA----ERRETIEEKRERAEELRE--RAAELEAEAEEKREAAA 561
Agg_substance NF033875
LPXTG-anchored aggregation substance; Aggregation substances, as described in Enterococcus, ...
 212-386 1.23e-04

LPXTG-anchored aggregation substance; Aggregation substances, as described in Enterococcus, are LPXTG-anchored large surface proteins that contribute to virulence. Several closely related paralogs may be found in a single strain.


Pssm-ID: 411439 [Multi-domain]  Cd Length: 1306  Bit Score: 44.70  E-value: 1.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955  212 SELEEESRLQDADVSAASLQSELAHSLDDGDQGQGAdaPGDTPTTRSPKTRKASSPQPSP---PEEILEPPKKRTSLSPA 288
Cdd:NF033875   71 TAVSEEATVQKDTTSQPTKVEEVASEKNGAEQSSAT--PNDTTNAQQPTVGAEKSAQEQPvvsPETTNEPLGQPTEVAPA 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955  289 EILEEKEVEVAKlqdeiSLQQAELQSLREELQRQKELRAQEDPGEALHSaLSDRDEAVNKAlelslqlnrvslERDSLSR 368
Cdd:NF033875  149 ENEANKSTSIPK-----EFETPDVDKAVDEAKKDPNITVVEKPAEDLGN-VSSKDLAAKEK------------EVDQLQK 210

                         170
                  ....*....|....*...
gi 767986955  369 ELLRAIRQKVAltqELEA 386
Cdd:NF033875  211 EQAKKIAQQAA---ELKA 225
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 80-384 2.92e-04

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 43.27  E-value: 2.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955   80 ERARALSELSEQNLRLSQQ----LAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQI 155
Cdd:pfam10174 447 EKERIIERLKEQREREDRErleeLESLKKENKDLKEKVSALQPELTEKESSLIDLKEHASSLASSGLKKDSKLKSLEIAV 526

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955  156 RGLREEVEKGEGRLQTTHEELLLLRR----ERREHSLELE--RARSEAGEALSALRRLQRRVSELEEESRLQDADVSAAS 229
Cdd:pfam10174 527 EQKKEECSKLENQLKKAHNAEEAVRTnpeiNDRIRLLEQEvaRYKEESGKAQAEVERLLGILREVENEKNDKDKKIAELE 606

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955  230 L--------QSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPSPPEEILEPPKKRTSlspaeILEEKEVEVAKL 301
Cdd:pfam10174 607 SltlrqmkeQNKKVANIKHGQQEMKKKGAQLLEEARRREDNLADNSQQLQLEELMGALEKTRQ-----ELDATKARLSST 681

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955  302 QDEISLQQAELQSLREELQRQKElRAQEDPGEALHSALSDRDEAVnKALELSlqlnrvSLERDSLSRELLRAIRQKVALT 381
Cdd:pfam10174 682 QQSLAEKDGHLTNLRAERRKQLE-EILEMKQEALLAAISEKDANI-ALLELS------SSKKKKTQEEVMALKREKDRLV 753


                  ...
gi 767986955  382 QEL 384
Cdd:pfam10174 754 HQL 756
 
Name Accession Description Interval E-value
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 26-420 1.38e-12

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 69.97  E-value: 1.38e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955  26 QQLERLQQENHELRRGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQASQT 105
Cdd:COG1196  298 ARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEA 377

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955 106 EQELQRELDALrgqcQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHeellllrrerre 185
Cdd:COG1196  378 EEELEELAEEL----LEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEE------------ 441

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955 186 hsLELERARSEAGEALSALRRLQRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKAS 265
Cdd:COG1196  442 --EALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGL 519

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955 266 SPQPSP-PEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQS-------LREELQRQKELRAQEDPGEALHS 337
Cdd:COG1196  520 RGLAGAvAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAkagratfLPLDKIRARAALAAALARGAIGA 599

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955 338 ALSDRDEAVNKALELSLQLNRVSLERDSLSRELLRAIRQKVALTQELEAWQDDMQVVIGQQLRSQRQKELSASASSSTPR 417
Cdd:COG1196  600 AVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEA 679


                 ...
gi 767986955 418 RAA 420
Cdd:COG1196  680 ELE 682
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 20-231 4.44e-10

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 62.00  E-value: 4.44e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955    20 QVQKPRQQLERLQQENHELRRGLAARGAE---WEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLS 96
Cdd:TIGR02168  713 ELEQLRKELEELSRQISALRKDLARLEAEveqLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIE 792

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955    97 QQLAQASQTEQ---ELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTH 173
Cdd:TIGR02168  793 QLKEELKALREaldELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELE 872

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 767986955   174 EELLLLRRERREHSLELERARSEAGEALSALRRLQRRVSELEEESRLQDADVSAASLQ 231
Cdd:TIGR02168  873 SELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELR 930
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 25-236 1.01e-09

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 60.72  E-value: 1.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955  25 RQQLERLQQENHELRRGLAARgaewEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSeqnlRLSQQLAQASQ 104
Cdd:COG1196  238 EAELEELEAELEELEAELEEL----EAELAELEAELEELRLELEELELELEEAQAEEYELLAELA----RLEQDIARLEE 309

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955 105 TEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERR 184
Cdd:COG1196  310 RRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELL 389

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767986955 185 EHSLELERARSEAGEALSALRRLQRRVSELEEESRLQDADVSAASLQSELAH 236
Cdd:COG1196  390 EALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEE 441
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 31-390 1.15e-09

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 60.72  E-value: 1.15e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955  31 LQQENHELRRGLAARGAEW-EARAVELEGDVEALRAQLGEQRSEQqdsgRERARALSELSEQNLRLSQQLAQASQTEQEL 109
Cdd:COG1196  218 LKEELKELEAELLLLKLRElEAELEELEAELEELEAELEELEAEL----AELEAELEELRLELEELELELEEAQAEEYEL 293

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955 110 QRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTtheeLLLLRRERREHSLE 189
Cdd:COG1196  294 LAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEE----AEAELAEAEEALLE 369

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955 190 LERARSEAGEALSALRR--LQRRVSELEEESRLQDADVSAASLQSELAHSLDDgdqgqgadapgdtpttrspktrkassp 267
Cdd:COG1196  370 AEAELAEAEEELEELAEelLEALRAAAELAAQLEELEEAEEALLERLERLEEE--------------------------- 422

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955 268 qpsppeeileppkKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKELRAQEDPGEALHSALSDRDEAVN 347
Cdd:COG1196  423 -------------LEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEA 489

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 767986955 348 KALELSLQLNRVSLERDSLSRELLRAIRQKVALTQELEAWQDD 390
Cdd:COG1196  490 AARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGV 532
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 25-320 6.39e-09

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 58.16  E-value: 6.39e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955    25 RQQLERLQQENHELRRGLA---ARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQ 101
Cdd:TIGR02169  694 QSELRRIENRLDELSQELSdasRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEED 773

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955   102 ASQTE---------------QELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQ-------DLEAQIRGLR 159
Cdd:TIGR02169  774 LHKLEealndlearlshsriPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQelqeqriDLKEQIKSIE 853

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955   160 EEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRLQRRVSELE-----EESRLQDADVSAASLQSEL 234
Cdd:TIGR02169  854 KEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEaqiekKRKRLSELKAKLEALEEEL 933

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955   235 AHSLDDGDQGQgadapgdtpttrspktrkaSSPQPSPPEEILEPPKKR-----TSLSPAEILEEKEVE-VAKLQDEISLQ 308
Cdd:TIGR02169  934 SEIEDPKGEDE-------------------EIPEEELSLEDVQAELQRveeeiRALEPVNMLAIQEYEeVLKRLDELKEK 994

                          330
                   ....*....|..
gi 767986955   309 QAELQSLREELQ 320
Cdd:TIGR02169  995 RAKLEEERKAIL 1006
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 20-217 2.90e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 56.22  E-value: 2.90e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955    20 QVQKPRQQLERLQQENHELRRGLAARGAEWEARAVELeGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQL 99
Cdd:TIGR02168  783 EIEELEAQIEQLKEELKALREALDELRAELTLLNEEA-ANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEI 861

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955   100 AQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLL 179
Cdd:TIGR02168  862 EELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNL 941

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 767986955   180 RRE-RREHSLELERARSEAGEALSALRRLQRRVSELEEE 217
Cdd:TIGR02168  942 QERlSEEYSLTLEEAEALENKIEDDEEEARRRLKRLENK 980
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
20-217 4.93e-08

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 55.31  E-value: 4.93e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955   20 QVQKPRQQLERLQQ--ENHELRRGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARAlselseqnlrlsq 97
Cdd:COG4913   243 ALEDAREQIELLEPirELAERYAAARERLAELEYLRAALRLWFAQRRLELLEAELEELRAELARLEA------------- 309

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955   98 QLAQASQTEQELQRELDALRGQCQAQALAG-AELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEEL 176
Cdd:COG4913   310 ELERLEARLDALREELDELEAQIRGNGGDRlEQLEREIERLERELEERERRRARLEALLAALGLPLPASAEEFAALRAEA 389

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 767986955  177 LLLRRERREhslELERARSEAGEALSALRRLQRRVSELEEE 217
Cdd:COG4913   390 AALLEALEE---ELEALEEALAEAEAALRDLRRELRELEAE 427
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 25-321 2.71e-07

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 53.15  E-value: 2.71e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955    25 RQQLERLQQENHELRRGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRlsqqLAQASQ 104
Cdd:TIGR02169  197 RQQLERLRREREKAERYQALLKEKREYEGYELLKEKEALERQKEAIERQLASLEEELEKLTEEISELEKR----LEEIEQ 272

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955   105 TEQELQRELDALRGQCQAQalagaeLRTRLESLQGE--------------NQMLQSRRQDLEAQIRGLREEVEKGEGRLQ 170
Cdd:TIGR02169  273 LLEELNKKIKDLGEEEQLR------VKEKIGELEAEiaslersiaekereLEDAEERLAKLEAEIDKLLAEIEELEREIE 346

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955   171 TTHEELLLLRRERREHSLELERARSEAGEALSALRRLQRRVSELEEEsrLQDADVSAASLQSELAHSLDDGDQ--GQGAD 248
Cdd:TIGR02169  347 EERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREK--LEKLKREINELKRELDRLQEELQRlsEELAD 424

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767986955   249 APGDTPTTRSPKTRKASSPQpsppEEILEPPKKRTSLSP-AEILEEKEVEVAKLQDEISLQQAELQSLREELQR 321
Cdd:TIGR02169  425 LNAAIAGIEAKINELEEEKE----DKALEIKKQEWKLEQlAADLSKYEQELYDLKEEYDRVEKELSKLQRELAE 494
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 26-357 1.03e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 51.21  E-value: 1.03e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955    26 QQLERLQQENHELRRGLAArgaeweARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSqqlaQASQT 105
Cdd:TIGR02168  213 ERYKELKAELRELELALLV------LRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVS----ELEEE 282

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955   106 EQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERRE 185
Cdd:TIGR02168  283 IEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEE 362

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955   186 HSLELERARSEAGEALSALRRLQRRVSELEEESRLQDADVS-AASLQSELAHSLDDGDQGQGADAPgdtptTRSPKTRKA 264
Cdd:TIGR02168  363 LEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIErLEARLERLEDRRERLQQEIEELLK-----KLEEAELKE 437

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955   265 SSPQPSPPEEILEPPKKRtslspaeiLEEKEVEVAKLQDEISLQQAELQSLREELQRqkeLRAQEDPGEALHSALSDRDE 344
Cdd:TIGR02168  438 LQAELEELEEELEELQEE--------LERLEEALEELREELEEAEQALDAAERELAQ---LQARLDSLERLQENLEGFSE 506

                          330
                   ....*....|...
gi 767986955   345 AVNKALELSLQLN 357
Cdd:TIGR02168  507 GVKALLKNQSGLS 519
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 25-231 1.13e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 51.21  E-value: 1.13e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955    25 RQQLERLQQENHELRRGLAARGAEWEaravELEGDVEALRAQLGEQRSEQQDSGREraraLSELSEQNLRLSQQLAQASQ 104
Cdd:TIGR02168  245 QEELKEAEEELEELTAELQELEEKLE----ELRLEVSELEEEIEELQKELYALANE----ISRLEQQKQILRERLANLER 316

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955   105 TEQELQRELDALRGQCQAQALAGAELRTRLESLQGEnqmlqsrRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERR 184
Cdd:TIGR02168  317 QLEELEAQLEELESKLDELAEELAELEEKLEELKEE-------LESLEAELEELEAELEELESRLEELEEQLETLRSKVA 389

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 767986955   185 EHSLELERARSEAGEALSALRRLQRRVSELEEESRLQDADVSAASLQ 231
Cdd:TIGR02168  390 QLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELK 436
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 47-239 2.68e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 50.06  E-value: 2.68e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955    47 AEWEARAVELEGDVEALRAQLGEQRSEQ---QDSGRERARALSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQ 123
Cdd:TIGR02168  680 EELEEKIEELEEKIAELEKALAELRKELeelEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTEL 759

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955   124 ALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALSA 203
Cdd:TIGR02168  760 EAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERR 839

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 767986955   204 LRRLQRRVSELEEE-----SRLQDADVSAASLQSELAHSLD 239
Cdd:TIGR02168  840 LEDLEEQIEELSEDieslaAEIEELEELIEELESELEALLN 880
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
25-217 2.89e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 49.91  E-value: 2.89e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955   25 RQQLERLQQEnhelRRGLAARGAEWEARAVELEGDVEALRAQlgeqrseqqdsgRERARALSELSEQNLRLSQQLAQASQ 104
Cdd:COG4913   609 RAKLAALEAE----LAELEEELAEAEERLEALEAELDALQER------------REALQRLAEYSWDEIDVASAEREIAE 672

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955  105 TEQELQR------ELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLL 178
Cdd:COG4913   673 LEAELERldassdDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALLE 752

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 767986955  179 LRRERrehsLELERARSEAGEALSA-LRRLQRRVSELEEE 217
Cdd:COG4913   753 ERFAA----ALGDAVERELRENLEErIDALRARLNRAEEE 788
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 39-385 4.09e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 49.28  E-value: 4.09e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955    39 RRGLAARGAEwEARAVELEGDVEalRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQASQTEQELQRELDALRG 118
Cdd:TIGR02168  657 PGGVITGGSA-KTNSSILERRRE--IEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRK 733

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955   119 QCqaqalagAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRerrehslELERARSEAG 198
Cdd:TIGR02168  734 DL-------ARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEA-------QIEQLKEELK 799

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955   199 EALSALRRLQRRVSELEEEsrLQDADVSAASLQSELAHslddgdqgqgadapgdtpttrspktrkasspqpsppeeilep 278
Cdd:TIGR02168  800 ALREALDELRAELTLLNEE--AANLRERLESLERRIAA------------------------------------------ 835

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955   279 pKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKELRAQEDpgEALHSALSDRDEAVNKALELSLQLNR 358
Cdd:TIGR02168  836 -TERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLE--EALALLRSELEELSEELRELESKRSE 912

                          330       340
                   ....*....|....*....|....*..
gi 767986955   359 VSLERDSLSRELLRAIRQKVALTQELE 385
Cdd:TIGR02168  913 LRRELEELREKLAQLELRLEGLEVRID 939
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 128-434 1.04e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 48.01  E-value: 1.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955 128 AELRTRLESLQG------------------ENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLE 189
Cdd:COG1196  196 GELERQLEPLERqaekaeryrelkeelkelEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLE 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955 190 LERARSEAGEALSALRRLQRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRspKTRKASSPQP 269
Cdd:COG1196  276 LEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELE--EELEEAEEEL 353

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955 270 SPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKELRAQEDPGEALHSALSDRDEAVNKA 349
Cdd:COG1196  354 EEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAEL 433

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955 350 LELSLQLNRVSLERDS----LSRELLRAIRQKVALTQELEAWQDDMQVVIGQQLRSQRQKELSASASSSTPRRAAPRFSL 425
Cdd:COG1196  434 EEEEEEEEEALEEAAEeeaeLEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAA 513


                 ....*....
gi 767986955 426 RLGPGPAGG 434
Cdd:COG1196  514 LLLAGLRGL 522
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
29-392 1.37e-05

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 47.73  E-value: 1.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955  29 ERLQQENHELRRGLAARGAEWEARAVELEGDVEALRAQLGEQrSEQQDSGRERARALSELSEQNLRLSQQLAQASQTEQE 108
Cdd:PRK02224 198 EKEEKDLHERLNGLESELAELDEEIERYEEQREQARETRDEA-DEVLEEHEERREELETLEAEIEDLRETIAETEREREE 276

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955 109 LQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSL 188
Cdd:PRK02224 277 LAEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDRLEECRVAAQAHNEEAESLREDADDLEE 356

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955 189 ELERARSEAGE-------ALSALRRLQRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSpkT 261
Cdd:PRK02224 357 RAEELREEAAEleseleeAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREERDELREREAELEA--T 434

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955 262 RKASSPQPSPPEEILEPPKKRTSLSP------AEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKELRAQEDPGEal 335
Cdd:PRK02224 435 LRTARERVEEAEALLEAGKCPECGQPvegsphVETIEEDRERVEELEAELEDLEEEVEEVEERLERAEDLVEAEDRIE-- 512

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767986955 336 hsALSDRDEAVNKALElslqLNRVSLERDSLSRELLRAirQKVALTQELEAWQDDMQ 392
Cdd:PRK02224 513 --RLEERREDLEELIA----ERRETIEEKRERAEELRE--RAAELEAEAEEKREAAA 561
PRK09039 PRK09039
peptidoglycan -binding protein;
26-158 6.10e-05

peptidoglycan -binding protein;


Pssm-ID: 181619 [Multi-domain]  Cd Length: 343  Bit Score: 44.96  E-value: 6.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955  26 QQLERLQQENHELRRGLAARgaewEARAVELEGDVEALRAQLGEQRSEQ---QDSGRERARALSELSEQNLRLSQQLAQA 102
Cdd:PRK09039  53 SALDRLNSQIAELADLLSLE----RQGNQDLQDSVANLRASLSAAEAERsrlQALLAELAGAGAAAEGRAGELAQELDSE 128

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767986955 103 SQTEQELQRELDALRGQCqaqalagAELRTRLESLQGENQMLQSRRQDLEAQIRGL 158
Cdd:PRK09039 129 KQVSARALAQVELLNQQI-------AALRRQLAALEAALDASEKRDRESQAKIADL 177
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 22-163 1.07e-04

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 44.94  E-value: 1.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955   22 QKPRQQLERLQQENHELRRGLAARGAEWEA-RAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQLA 100
Cdd:COG3096   495 QTARELLRRYRSQQALAQRLQQLRAQLAELeQRLRQQQNAERLLEEFCQRIGQQLDAAEELEELLAELEAQLEELEEQAA 574

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767986955  101 QASQTEQELQRELDALRGQCQ---AQALAGAELRTRLESLQGE-NQMLQSRRQDLEAQIRGLREEVE 163
Cdd:COG3096   575 EAVEQRSELRQQLEQLRARIKelaARAPAWLAAQDALERLREQsGEALADSQEVTAAMQQLLERERE 641
Agg_substance NF033875
LPXTG-anchored aggregation substance; Aggregation substances, as described in Enterococcus, ...
 212-386 1.23e-04

LPXTG-anchored aggregation substance; Aggregation substances, as described in Enterococcus, are LPXTG-anchored large surface proteins that contribute to virulence. Several closely related paralogs may be found in a single strain.


Pssm-ID: 411439 [Multi-domain]  Cd Length: 1306  Bit Score: 44.70  E-value: 1.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955  212 SELEEESRLQDADVSAASLQSELAHSLDDGDQGQGAdaPGDTPTTRSPKTRKASSPQPSP---PEEILEPPKKRTSLSPA 288
Cdd:NF033875   71 TAVSEEATVQKDTTSQPTKVEEVASEKNGAEQSSAT--PNDTTNAQQPTVGAEKSAQEQPvvsPETTNEPLGQPTEVAPA 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955  289 EILEEKEVEVAKlqdeiSLQQAELQSLREELQRQKELRAQEDPGEALHSaLSDRDEAVNKAlelslqlnrvslERDSLSR 368
Cdd:NF033875  149 ENEANKSTSIPK-----EFETPDVDKAVDEAKKDPNITVVEKPAEDLGN-VSSKDLAAKEK------------EVDQLQK 210

                         170
                  ....*....|....*...
gi 767986955  369 ELLRAIRQKVAltqELEA 386
Cdd:NF033875  211 EQAKKIAQQAA---ELKA 225
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 20-171 1.99e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 43.21  E-value: 1.99e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955  20 QVQKPRQQLERLQQENHELRRGLAARGAEWEARAVELE-----------------GDVEALRAQLGEQRSEQQDSGRERA 82
Cdd:COG4942   77 ELAALEAELAELEKEIAELRAELEAQKEELAELLRALYrlgrqpplalllspedfLDAVRRLQYLKYLAPARREQAEELR 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955  83 RALSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEV 162
Cdd:COG4942  157 ADLAELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEA 236


                 ....*....
gi 767986955 163 EKGEGRLQT 171
Cdd:COG4942  237 AAAAERTPA 245
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 80-384 2.92e-04

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 43.27  E-value: 2.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955   80 ERARALSELSEQNLRLSQQ----LAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQI 155
Cdd:pfam10174 447 EKERIIERLKEQREREDRErleeLESLKKENKDLKEKVSALQPELTEKESSLIDLKEHASSLASSGLKKDSKLKSLEIAV 526

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955  156 RGLREEVEKGEGRLQTTHEELLLLRR----ERREHSLELE--RARSEAGEALSALRRLQRRVSELEEESRLQDADVSAAS 229
Cdd:pfam10174 527 EQKKEECSKLENQLKKAHNAEEAVRTnpeiNDRIRLLEQEvaRYKEESGKAQAEVERLLGILREVENEKNDKDKKIAELE 606

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955  230 L--------QSELAHSLDDGDQGQGADAPGDTPTTRSPKTRKASSPQPSPPEEILEPPKKRTSlspaeILEEKEVEVAKL 301
Cdd:pfam10174 607 SltlrqmkeQNKKVANIKHGQQEMKKKGAQLLEEARRREDNLADNSQQLQLEELMGALEKTRQ-----ELDATKARLSST 681

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955  302 QDEISLQQAELQSLREELQRQKElRAQEDPGEALHSALSDRDEAVnKALELSlqlnrvSLERDSLSRELLRAIRQKVALT 381
Cdd:pfam10174 682 QQSLAEKDGHLTNLRAERRKQLE-EILEMKQEALLAAISEKDANI-ALLELS------SSKKKKTQEEVMALKREKDRLV 753


                  ...
gi 767986955  382 QEL 384
Cdd:pfam10174 754 HQL 756
Macoilin pfam09726
Macoilin family; The Macoilin proteins has an N-terminal portion that is composed of 5 ...
 84-231 3.01e-04

Macoilin family; The Macoilin proteins has an N-terminal portion that is composed of 5 trasnmembrane helices, followed by a C-terminal coiled-coil region. Macoilin is a highly conserved protein present in eukaryotes. Macoilin appears to be found in the ER and be involved in the function of neurons.


Pssm-ID: 462859 [Multi-domain]  Cd Length: 670  Bit Score: 43.30  E-value: 3.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955   84 ALSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAqalagaeLRTRLESLQGENQMLQSRRQDLEAQIRGLREEVE 163
Cdd:pfam09726 396 ALVRLEQDIKKLKAELQASRQTEQELRSQISSLTSLERS-------LKSELGQLRQENDLLQTKLHNAVSAKQKDKQTVQ 468

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767986955  164 KGEGRLQTT--HEELLLLRRERREHSLELERARSEAGEALSALRR------LQRRVSELEEESRLQDADVSAASLQ 231
Cdd:pfam09726 469 QLEKRLKAEqeARASAEKQLAEEKKRKKEEEATAARAVALAAASRgectesLKQRKRELESEIKKLTHDIKLKEEQ 544
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 20-229 3.40e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 42.83  E-value: 3.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955  20 QVQKPRQQLERLQQENHELRRGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQL 99
Cdd:COG4942   31 QLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEELAELL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955 100 AQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLL 179
Cdd:COG4942  111 RALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAELEEERAAL 190

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 767986955 180 RRERREHSLELERARSEAGEALSALRRLQRRVSELEEESRLQDADVSAAS 229
Cdd:COG4942  191 EALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAA 240
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 50-389 4.49e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 42.74  E-value: 4.49e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955    50 EARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGAE 129
Cdd:TIGR02168  644 GYRIVTLDGDLVRPGGVITGGSAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEE 723

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955   130 LRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSLELERARSEAGEALSALRRLQR 209
Cdd:TIGR02168  724 LSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALRE 803

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955   210 RVSELEEEsrLQDADVSAASLQSELAHSLDDgdqgqgadapgdtpttrspktrkasspqpsppeeileppkkrtslspae 289
Cdd:TIGR02168  804 ALDELRAE--LTLLNEEAANLRERLESLERR------------------------------------------------- 832

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955   290 iLEEKEVEVAKLQDEISLQQAELQSLreelqrQKELRAQEDPGEALHSALsdrDEAVNKALELSLQLNRVSLERDSLSRE 369
Cdd:TIGR02168  833 -IAATERRLEDLEEQIEELSEDIESL------AAEIEELEELIEELESEL---EALLNERASLEEALALLRSELEELSEE 902

                          330       340
                   ....*....|....*....|
gi 767986955   370 LLRAIRQKVALTQELEAWQD 389
Cdd:TIGR02168  903 LRELESKRSELRRELEELRE 922
Nucleoporin_FG2 pfam15967
Nucleoporin FG repeated region; Nucleoporin_FG2, or nucleoporin p58/p45, is a family of ...
 59-171 1.13e-03

Nucleoporin FG repeated region; Nucleoporin_FG2, or nucleoporin p58/p45, is a family of chordate nucleoporins. The proteins carry many repeats of the FG sequence motif.


Pssm-ID: 435043 [Multi-domain]  Cd Length: 586  Bit Score: 41.19  E-value: 1.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955   59 DVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQASQTEQELQRELDALRgQCQAQALAGAELRTRLES-- 136
Cdd:pfam15967 252 DVENFQKFVKEQKQVQEEISRMSSKAMLKVQDDIKALKQLLSVAASGLQRNSLAIDKLK-IETAQELKNADIALRTQKtp 330

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 767986955  137 --LQGEN----QMLQSRRQDLEAQIRGLREEVEKGEGRLQT 171
Cdd:pfam15967 331 pgLQHENtapaDYFRSLVEQFEVQLQQYRQQIEELENHLTT 371
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
79-247 1.49e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 41.05  E-value: 1.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955   79 RERARALSELSEQNlrlsQQLAQASQTEQELQRELDALRGQCQAQALAgaELRTRLESLQGENQMLQSRRQDLEAQIRGL 158
Cdd:COG4913   248 REQIELLEPIRELA----ERYAAARERLAELEYLRAALRLWFAQRRLE--LLEAELEELRAELARLEAELERLEARLDAL 321

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955  159 REEVEKGEGRLQTTHEELLLLRRErrehslELERARSEAGEALSALRRLQRRVSELEEESRLQDADVsaASLQSELAHSL 238
Cdd:COG4913   322 REELDELEAQIRGNGGDRLEQLER------EIERLERELEERERRRARLEALLAALGLPLPASAEEF--AALRAEAAALL 393


                  ....*....
gi 767986955  239 DDGDQGQGA 247
Cdd:COG4913   394 EALEEELEA 402
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
20-392 1.92e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 40.52  E-value: 1.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955  20 QVQKPRQQLERLQQENHELRRGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELseQNLRLSQQL 99
Cdd:COG4717   50 RLEKEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREEL--EKLEKLLQL 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955 100 AQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLL 179
Cdd:COG4717  128 LPLYQELEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQR 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955 180 RRERREhslELERARSEAGEALSALRRLQRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSP 259
Cdd:COG4717  208 LAELEE---ELEEAQEELEELEEELEQLENELEAAALEERLKEARLLLLIAAALLALLGLGGSLLSLILTIAGVLFLVLG 284

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955 260 KTRKASSPQPSPPEEILEPPKKRTSLSPAEILEEKEVE--VAKLQDEISLQQAELQSLREELQRQKELRAQEDpgEALHS 337
Cdd:COG4717  285 LLALLFLLLAREKASLGKEAEELQALPALEELEEEELEelLAALGLPPDLSPEELLELLDRIEELQELLREAE--ELEEE 362

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767986955 338 ALSDRDEAVNKALelslqLNRVSLERDSLSRELLRAIRQKVALTQELEAWQDDMQ 392
Cdd:COG4717  363 LQLEELEQEIAAL-----LAEAGVEDEEELRAALEQAEEYQELKEELEELEEQLE 412
mukB PRK04863
chromosome partition protein MukB;
20-164 3.37e-03

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 39.94  E-value: 3.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955   20 QVQKPRQQLERLQQENHELRRG--LAARGAEWEARAVELEGDVEALRAQLGEQR---SEQQDSGRERARALSELSEQNLR 94
Cdd:PRK04863  514 QLQQLRMRLSELEQRLRQQQRAerLLAEFCKRLGKNLDDEDELEQLQEELEARLeslSESVSEARERRMALRQQLEQLQA 593

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955   95 LSQQLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEK 164
Cdd:PRK04863  594 RIQRLAARAPAWLAAQDALARLREQSGEEFEDSQDVTEYMQQLLERERELTVERDELAARKQALDEEIER 663
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
20-364 3.85e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 39.50  E-value: 3.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955  20 QVQKPRQQLERLQQENHELRRGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEqnlrLSQQL 99
Cdd:COG4372    7 KVGKARLSLFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQ----LEEEL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955 100 AQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLL 179
Cdd:COG4372   83 EELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955 180 RRERRehSLELERARSEAGEALSALRRLQRRVSELEEESRLQDADVSAASLQSELAHSLDDGDQGQGADAPGDTPTTRSP 259
Cdd:COG4372  163 QEELA--ALEQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLD 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955 260 KTR-KASSPQPSPPEEILEPPKKRTSLSPAEILEEKEVEVAKLQDEISLQQAELQSLREELQRQKELRAQEDPGEALHSA 338
Cdd:COG4372  241 ALElEEDKEELLEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAA 320

                        330       340
                 ....*....|....*....|....*.
gi 767986955 339 LSDRDEAVNKALELSLQLNRVSLERD 364
Cdd:COG4372  321 LLELAKKLELALAILLAELADLLQLL 346
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
28-235 4.19e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 39.37  E-value: 4.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955  28 LERLQQENHELRRGLAARGAEWEARAVELEGDVEALRAQLGEqrseqqdsgreraraLSELSEQNLRLSQQLAQASQTEQ 107
Cdd:COG4717   48 LERLEKEADELFKPQGRKPELNLKELKELEEELKEAEEKEEE---------------YAELQEELEELEEELEELEAELE 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955 108 ELQRELDALRGQCQAQALAG--AELRTRLESLQGENQMLQSR---RQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRE 182
Cdd:COG4717  113 ELREELEKLEKLLQLLPLYQelEALEAELAELPERLEELEERleeLRELEEELEELEAELAELQEELEELLEQLSLATEE 192

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767986955 183 RREHSLE-LERARSEAGEALSALRRLQRRVSELEEESRLQDADVSAASLQSELA 235
Cdd:COG4717  193 ELQDLAEeLEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLK 246
hsdR PRK11448
type I restriction enzyme EcoKI subunit R; Provisional
 20-102 4.57e-03

type I restriction enzyme EcoKI subunit R; Provisional


Pssm-ID: 236912 [Multi-domain]  Cd Length: 1123  Bit Score: 39.55  E-value: 4.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955   20 QVQKPRQQLERLQQE---NHELRRGLAARGAEWEARAVELEGDVEALRA---QLGEQRSEQQDSGRERARALSELSEQNL 93
Cdd:PRK11448  150 EVLTLKQQLELQAREkaqSQALAEAQQQELVALEGLAAELEEKQQELEAqleQLQEKAAETSQERKQKRKEITDQAAKRL 229

                          90
                  ....*....|....*...
gi 767986955   94 RLS---------QQLAQA 102
Cdd:PRK11448  230 ELSeeetrilidQQLRKA 247
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 29-217 5.06e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 39.53  E-value: 5.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955  29 ERLQQENHELRRGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSEQNLRLSQQLAQASQTEQE 108
Cdd:COG1196  615 YYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELE 694

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955 109 LQRELDALRgqcqAQALAGAELRTRLESLQGENQMLQSRRQDLEAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSL 188
Cdd:COG1196  695 LEEALLAEE----EEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELE 770

                        170       180       190
                 ....*....|....*....|....*....|...
gi 767986955 189 ELERARSEAGE----ALSALRRLQRRVSELEEE 217
Cdd:COG1196  771 RLEREIEALGPvnllAIEEYEELEERYDFLSEQ 803
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 74-164 5.49e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 38.98  E-value: 5.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955  74 QQDSGRERARALSELSEQNLRLSQQLAQASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEA 153
Cdd:COG4942   18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRA 97

                         90
                 ....*....|.
gi 767986955 154 QIRGLREEVEK 164
Cdd:COG4942   98 ELEAQKEELAE 108
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 22-154 8.50e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 38.57  E-value: 8.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955   22 QKPRQQLERLQQENHELRRGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELSE-QNLRLSQQLA 100
Cdd:pfam17380 456 QERQQQVERLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEERKQAMIEEERKRKLLEKEMEErQKAIYEEERR 535

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767986955  101 QASQTEQELQRELDAlRGQCQAQALAGAELRTRLESLQGENQMLQSRRQDLEAQ 154
Cdd:pfam17380 536 REAEEERRKQQEMEE-RRRIQEQMRKATEERSRLEAMEREREMMRQIVESEKAR 588
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
25-163 8.90e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 38.74  E-value: 8.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955   25 RQQLERLQQENHELrrglaargaewEARAVELEGDVEALRAQLGEQRSEQQDS-GRERARALSELSEQN---LRLSQQLA 100
Cdd:COG4913   301 RAELARLEAELERL-----------EARLDALREELDELEAQIRGNGGDRLEQlEREIERLERELEERErrrARLEALLA 369

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767986955  101 QASQTEQELQRELDALRGQCQAQALAGAELRTRLESLQGEnqmLQSRRQDLEAQIRGLREEVE 163
Cdd:COG4913   370 ALGLPLPASAEEFAALRAEAAALLEALEEELEALEEALAE---AEAALRDLRRELRELEAEIA 429
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 25-151 9.06e-03

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 38.50  E-value: 9.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955   25 RQQLERLQQENHElrrglaargaeweARAVELEGDVEALRAQLGEQRSEQQDSGRERARALSELS-----------EQNL 93
Cdd:PRK10929  202 RQELARLRSELAK-------------KRSQQLDAYLQALRNQLNSQRQREAERALESTELLAEQSgdlpksivaqfKINR 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955   94 RLSQQLAQASQ------------TEQELQ--RELDALRGQCQ---AQALAGAELRTRLESL-------QGENQMLQSRRQ 149
Cdd:PRK10929  269 ELSQALNQQAQrmdliasqqrqaASQTLQvrQALNTLREQSQwlgVSNALGEALRAQVARLpempkpqQLDTEMAQLRVQ 348


                  ..
gi 767986955  150 DL 151
Cdd:PRK10929  349 RL 350
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 26-235 9.20e-03

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 38.56  E-value: 9.20e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955    26 QQLERLQQENHELRRGLAARGAEWEARAVELEGDVEALRAQLGEQRSEQ----QDSG-------------RERARALSEL 88
Cdd:pfam15921  317 RQLSDLESTVSQLRSELREAKRMYEDKIEELEKQLVLANSELTEARTERdqfsQESGnlddqlqklladlHKREKELSLE 396

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955    89 SEQNLRLSQQLAQASQTEQELQRELD--------------ALRGQCQAQalagaeLRTRLESLQGENQMLQ---SRRQDL 151
Cdd:pfam15921  397 KEQNKRLWDRDTGNSITIDHLRRELDdrnmevqrleallkAMKSECQGQ------MERQMAAIQGKNESLEkvsSLTAQL 470

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955   152 EAQIRGLREEVEKGEGRLQTTHEELLLLRRERREHSlELERARSEAGEALSALR-RLQRRVSELE----EESRLQDADVS 226
Cdd:pfam15921  471 ESTKEMLRKVVEELTAKKMTLESSERTVSDLTASLQ-EKERAIEATNAEITKLRsRVDLKLQELQhlknEGDHLRNVQTE 549


                   ....*....
gi 767986955   227 AASLQSELA 235
Cdd:pfam15921  550 CEALKLQMA 558
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
26-171 9.20e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 38.46  E-value: 9.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767986955  26 QQLERLQQENHELRRGLAARGAEWEARAVELEGDVEALRA-----QLGEQRSEQQDSGRERARALSELSEQNLRLSQQLA 100
Cdd:COG3206  219 QQLSELESQLAEARAELAEAEARLAALRAQLGSGPDALPEllqspVIQQLRAQLAELEAELAELSARYTPNHPDVIALRA 298

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767986955 101 QASQTEQELQRELDALRGQCQAQAlagAELRTRLESLQGENQMLQSRRQDL---EAQIRGLREEVEKGEGRLQT 171
Cdd:COG3206  299 QIAALRAQLQQEAQRILASLEAEL---EALQAREASLQAQLAQLEARLAELpelEAELRRLEREVEVARELYES 369
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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