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Conserved domains on  [gi|768010972|ref|XP_011525591|]
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zinc finger protein 227 isoform X1 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204794)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
23-83 3.92e-27

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 104.60  E-value: 3.92e-27
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 768010972    23 VTFKDVAVVFSREELRLLDLTQRKLYRDVMVENFKNLVAVGHLPFQPDMVSQLEAEEKLWM 83
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
406-779 2.24e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.56  E-value: 2.24e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010972 406 KPYKCEECGKGFTQAAHFHIHQRVHTGEKPYKCDV--CGKGFSHNSPLICHRRVHTGEKPYKCEACGKGFTRNTDLHIHF 483
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010972 484 RVHTGE-KPYKCKECGKGFSQ--------ASNLQVHQNVHTGEKRFKCET--------------CGKGFSQSSKLQTHQR 540
Cdd:COG5048  112 SSSSNSnDNNLLSSHSLPPSSrdpqlpdlLSISNLRNNPLPGNNSSSVNTpqsnslhpplpansLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010972 541 VHTGEKPYRCDVCGKDFSYSSNLKLHQVIHTGEKPYKCEECGKGF------SWRSNLHAHQRVHSGEKPYKCEQCDKSFS 614
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010972 615 QAIDFRVHQRVHTG-EKPYKCGVCGKGFSQSSGLQSHQR--VHTGE--KPYKCDV--CGKGFRYSSQFIYHQRGHTGEKP 687
Cdd:COG5048  272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010972 688 YKC--EECGKGFGRSLNLRHHQRVH-----TGEKPHICE--ECGKAFSLPSNLRVHLGVHT--REKLFKCEECGKGFSQS 756
Cdd:COG5048  352 AKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLsfRPYNCKNPPCSKSFNRH 431

                        410       420
                 ....*....|....*....|...
gi 768010972 757 ARLEAHQRVHTGEKPYKCDICDK 779
Cdd:COG5048  432 YNLIPHKKIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
342-363 2.58e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.58e-03
                          10        20
                  ....*....|....*....|..
gi 768010972  342 HYRTHTGEKPYKCEECGKCFSQ 363
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
23-83 3.92e-27

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 104.60  E-value: 3.92e-27
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 768010972    23 VTFKDVAVVFSREELRLLDLTQRKLYRDVMVENFKNLVAVGHLPFQPDMVSQLEAEEKLWM 83
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 23-63 4.62e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 80.98  E-value: 4.62e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 768010972   23 VTFKDVAVVFSREELRLLDLTQRKLYRDVMVENFKNLVAVG 63
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 23-60 6.14e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 69.12  E-value: 6.14e-15
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 768010972  23 VTFKDVAVVFSREELRLLDLTQRKLYRDVMVENFKNLV 60
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
406-779 2.24e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.56  E-value: 2.24e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010972 406 KPYKCEECGKGFTQAAHFHIHQRVHTGEKPYKCDV--CGKGFSHNSPLICHRRVHTGEKPYKCEACGKGFTRNTDLHIHF 483
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010972 484 RVHTGE-KPYKCKECGKGFSQ--------ASNLQVHQNVHTGEKRFKCET--------------CGKGFSQSSKLQTHQR 540
Cdd:COG5048  112 SSSSNSnDNNLLSSHSLPPSSrdpqlpdlLSISNLRNNPLPGNNSSSVNTpqsnslhpplpansLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010972 541 VHTGEKPYRCDVCGKDFSYSSNLKLHQVIHTGEKPYKCEECGKGF------SWRSNLHAHQRVHSGEKPYKCEQCDKSFS 614
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010972 615 QAIDFRVHQRVHTG-EKPYKCGVCGKGFSQSSGLQSHQR--VHTGE--KPYKCDV--CGKGFRYSSQFIYHQRGHTGEKP 687
Cdd:COG5048  272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010972 688 YKC--EECGKGFGRSLNLRHHQRVH-----TGEKPHICE--ECGKAFSLPSNLRVHLGVHT--REKLFKCEECGKGFSQS 756
Cdd:COG5048  352 AKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLsfRPYNCKNPPCSKSFNRH 431

                        410       420
                 ....*....|....*....|...
gi 768010972 757 ARLEAHQRVHTGEKPYKCDICDK 779
Cdd:COG5048  432 YNLIPHKKIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
394-419 6.40e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 6.40e-04
                          10        20
                  ....*....|....*....|....*.
gi 768010972  394 NLRVHQRVHRGEKPYKCEECGKGFTQ 419
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
342-363 2.58e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.58e-03
                          10        20
                  ....*....|....*....|..
gi 768010972  342 HYRTHTGEKPYKCEECGKCFSQ 363
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
23-83 3.92e-27

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 104.60  E-value: 3.92e-27
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 768010972    23 VTFKDVAVVFSREELRLLDLTQRKLYRDVMVENFKNLVAVGHLPFQPDMVSQLEAEEKLWM 83
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 23-63 4.62e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 80.98  E-value: 4.62e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 768010972   23 VTFKDVAVVFSREELRLLDLTQRKLYRDVMVENFKNLVAVG 63
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 23-60 6.14e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 69.12  E-value: 6.14e-15
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 768010972  23 VTFKDVAVVFSREELRLLDLTQRKLYRDVMVENFKNLV 60
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
406-779 2.24e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.56  E-value: 2.24e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010972 406 KPYKCEECGKGFTQAAHFHIHQRVHTGEKPYKCDV--CGKGFSHNSPLICHRRVHTGEKPYKCEACGKGFTRNTDLHIHF 483
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010972 484 RVHTGE-KPYKCKECGKGFSQ--------ASNLQVHQNVHTGEKRFKCET--------------CGKGFSQSSKLQTHQR 540
Cdd:COG5048  112 SSSSNSnDNNLLSSHSLPPSSrdpqlpdlLSISNLRNNPLPGNNSSSVNTpqsnslhpplpansLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010972 541 VHTGEKPYRCDVCGKDFSYSSNLKLHQVIHTGEKPYKCEECGKGF------SWRSNLHAHQRVHSGEKPYKCEQCDKSFS 614
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010972 615 QAIDFRVHQRVHTG-EKPYKCGVCGKGFSQSSGLQSHQR--VHTGE--KPYKCDV--CGKGFRYSSQFIYHQRGHTGEKP 687
Cdd:COG5048  272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010972 688 YKC--EECGKGFGRSLNLRHHQRVH-----TGEKPHICE--ECGKAFSLPSNLRVHLGVHT--REKLFKCEECGKGFSQS 756
Cdd:COG5048  352 AKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLsfRPYNCKNPPCSKSFNRH 431

                        410       420
                 ....*....|....*....|...
gi 768010972 757 ARLEAHQRVHTGEKPYKCDICDK 779
Cdd:COG5048  432 YNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
275-706 8.94e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.64  E-value: 8.94e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010972 275 EKCFSQSSHLRTHQRIHPGEKLNRCHESGD---CFNKSSFHSYQSNHTGEKSYRC-DSCGKGFSSSTGLIIHYRTHTGEK 350
Cdd:COG5048   40 TDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdksFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSSSSSNSND 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010972 351 PYKCEECGKCFSQSSNFQCHQRVHTEEKPYKCEECGkgfgwsvnlrvhqrvhrgekpykceecGKGFTQAAHFHIHQRVH 430
Cdd:COG5048  120 NNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNN---------------------------SSSVNTPQSNSLHPPLP 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010972 431 TGEKpykcdvCGKGFSHNSPLICHRRVHTGEKPYKCEACGKgFTRNTDLHIHFRVHTGEKPYKCKECGKGFSQASNLQVH 510
Cdd:COG5048  173 ANSL------SKDPSSNLSLLISSNVSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSP 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010972 511 QNVHTGEKRFKCETCG------KGFSQSSKLQTHQRVHTG-EKPYRCDVCGKDFSYSSNLKLHQ--VIHTGE--KPYKCE 579
Cdd:COG5048  246 SSLSSSDSSSSASESPrsslptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCP 325

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010972 580 E--CGKGFSWRSNLHAHQRVHSGEKPYKC--EQCDKSFSQAIDFRVHQRV--HTGEKPYKCGV-----CGKGFSQSSGLQ 648
Cdd:COG5048  326 YslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSEtlsnsCIRNFKRDSNLS 405

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010972 649 SHQRVHTGEKP--YKCDVCGKGFRYSSQFIYHQRGHTGEKPYKCEECGKgFGRSLNLRHH 706
Cdd:COG5048  406 LHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 600-683 2.26e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.79  E-value: 2.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010972 600 GEKPYKCE--QCDKSFSQAIDFRVHqRVHtgekpykcGVCGKGFSQSSGLQSHQRVHTGEKPYKCDVCGKGFRYSSQFIY 677
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 768010972 678 HqRGHT 683
Cdd:COG5189  417 H-RKHS 421
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
520-798 1.26e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.46  E-value: 1.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010972 520 FKCETCGKGFSQSSKLQTHQRVHTGEKPYRCDVCGKDFSYSSNLKL--HQVIHTGEKPYKCEECGKG--FSWRSNLHAHQ 595
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELsrHLRTHHNNPSDLNSKSLPLsnSKASSSSLSSS 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010972 596 RVHS--GEKPYKCEQCDKSFSQAIDFRVHQRVHTGEKPYKCGVCGKGFSQSSGLQ-------------------SHQRVH 654
Cdd:COG5048  114 SSNSndNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHpplpanslskdpssnlsllISSNVS 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010972 655 TGEKPYKCDVCGKGFRYSSQFIYHQRGHTGEKPYKCEECGKGFGRSLNLRHHQRVHTGEKPHICEECG------KAFSLP 728
Cdd:COG5048  194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPrsslptASSQSS 273

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 768010972 729 SNLRVHLGVHTREKL-FKCEECGKGFSQSARLEAHQR--VHTGE--KPYKCDI--CDKDFRHRSRLTYHQKVHTGKK 798
Cdd:COG5048  274 SPNESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350
zf-H2C2_2 pfam13465
Zinc-finger double domain;
394-419 6.40e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 6.40e-04
                          10        20
                  ....*....|....*....|....*.
gi 768010972  394 NLRVHQRVHRGEKPYKCEECGKGFTQ 419
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
647-671 6.79e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 6.79e-04
                          10        20
                  ....*....|....*....|....*
gi 768010972  647 LQSHQRVHTGEKPYKCDVCGKGFRY 671
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
535-559 6.99e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.99e-04
                          10        20
                  ....*....|....*....|....*
gi 768010972  535 LQTHQRVHTGEKPYRCDVCGKDFSY 559
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 488-566 1.09e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 1.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010972 488 GEKPYKCK--ECGKGFSQASNLQVHQnvhtgekrfKCETCGKGFSQSSKLQTHQRVHTGEKPYRCDVCGKDFSYSSNLKL 565
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 .
gi 768010972 566 H 566
Cdd:COG5189  417 H 417
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 572-655 1.41e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010972 572 GEKPYKCE--ECGKGFSWRSNLHAHqRVHSGEKPYKCEQCDKSfsqaidfrVHQRVHTGEKPYKCGVCGKGFSQSSGLQS 649
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHGHQNQKLHENPSPE--------KMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 768010972 650 HqRVHT 655
Cdd:COG5189  417 H-RKHS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 617-711 1.43e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010972 617 IDFRVHQRVHTGEKPYKCGV--CGKGFSQSSGLQSHqRVHTGEKPYKCDVCGKgfryssqfIYHQRGHTGEKPYKCEECG 694
Cdd:COG5189  335 IDTPSRMLKVKDGKPYKCPVegCNKKYKNQNGLKYH-MLHGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCD 405

                         90
                 ....*....|....*..
gi 768010972 695 KGFGRSLNLRHHqRVHT 711
Cdd:COG5189  406 KRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
758-783 1.96e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.96e-03
                          10        20
                  ....*....|....*....|....*.
gi 768010972  758 RLEAHQRVHTGEKPYKCDICDKDFRH 783
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
562-586 2.46e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.46e-03
                          10        20
                  ....*....|....*....|....*
gi 768010972  562 NLKLHQVIHTGEKPYKCEECGKGFS 586
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
342-363 2.58e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.58e-03
                          10        20
                  ....*....|....*....|..
gi 768010972  342 HYRTHTGEKPYKCEECGKCFSQ 363
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 712-792 3.67e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 3.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010972 712 GEKPHICE--ECGKAFSLPSNLRVHLgvhtreklfKCEECGKGFSQSARLEAHQRVHTGEKPYKCDICDKDFRHRSRLTY 789
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ...
gi 768010972 790 HQK 792
Cdd:COG5189  417 HRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
594-615 3.86e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.86e-03
                          10        20
                  ....*....|....*....|..
gi 768010972  594 HQRVHSGEKPYKCEQCDKSFSQ 615
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
482-503 4.79e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.79e-03
                          10        20
                  ....*....|....*....|..
gi 768010972  482 HFRVHTGEKPYKCKECGKGFSQ 503
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
426-447 4.89e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.89e-03
                          10        20
                  ....*....|....*....|..
gi 768010972  426 HQRVHTGEKPYKCDVCGKGFSH 447
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 404-455 6.12e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 6.12e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 768010972 404 GEKPYKCE--ECGKGFTQA-------AHFHIHQRVH------------TGEKPYKCDVCGKGFSHNSPLICHR 455
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQnglkyhmLHGHQNQKLHenpspekmnifsAKDKPYRCEVCDKRYKNLNGLKYHR 418
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 492-514 6.65e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 6.65e-03
                          10        20
                  ....*....|....*....|...
gi 768010972  492 YKCKECGKGFSQASNLQVHQNVH 514
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 656-736 6.84e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 6.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768010972 656 GEKPYKCDVCGKGFRYSSQF--IYHQR-GHTGEKPYKCEECGKgfgrslnlrhHQRVHTGEKPHICEECGKAFSLPSNLR 732
Cdd:COG5189  346 DGKPYKCPVEGCNKKYKNQNglKYHMLhGHQNQKLHENPSPEK----------MNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                 ....
gi 768010972 733 VHLG 736
Cdd:COG5189  416 YHRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
618-643 7.03e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.03e-03
                          10        20
                  ....*....|....*....|....*.
gi 768010972  618 DFRVHQRVHTGEKPYKCGVCGKGFSQ 643
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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