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Conserved domains on  [gi|768004117|ref|XP_011526611|]
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podocan-like protein 1 isoform X2 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11471162)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
217-489 2.51e-21

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 96.54  E-value: 2.51e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 217 ALSRQTQLRELYLQHNQLTDSGLDattFSKLHSLEYLDLSHNQLTTVPAGLPR--TLAILHLGRNRIRQVEAArLHGARG 294
Cdd:COG4886  108 ELSNLTNLESLDLSGNQLTDLPEE---LANLTNLKELDLSNNQLTDLPEPLGNltNLKSLDLSNNQLTDLPEE-LGNLTN 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 295 LRYLLLQHNQLGSsgLPAgALRPLRGLHTLHLYGNGLDRVPPALPR--RLRALVLPHNHVAALgardlvatPGLTEL-NL 371
Cdd:COG4886  184 LKELDLSNNQITD--LPE-PLGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDL--------PELGNLtNL 252

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 372 AYnrlasarvhhrafrrlralrsLDLAGNQLTRLPMGLP-TGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLrvg 450
Cdd:COG4886  253 EE---------------------LDLSNNQLTDLPPLANlTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLL--- 308

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 768004117 451 dIGPGTWHELQALQMLDLSHNELSFVPPDLPEALEELHL 489
Cdd:COG4886  309 -NLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSL 346
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
57-345 2.06e-12

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.19  E-value: 2.06e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117  57 TVDCDGLDLRVFPDNITRAA--QHLSLQNNQLQELPyNELSRLSGLRTLNLHNNLISsealsgpsvsapvppcrgsgcqp 134
Cdd:COG4886  117 SLDLSGNQLTDLPEELANLTnlKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLT----------------------- 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 135 sdgDLPPHLWGeagtqvrvppqqpaeqrwpaprrLPRLRGHrhpqplqqpaqlpaaqpaaltraappagSPANNLISKVP 214
Cdd:COG4886  173 ---DLPEELGN-----------------------LTNLKEL----------------------------DLSNNQITDLP 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 215 rGALSRQTQLRELYLQHNQLTDsgLDAtTFSKLHSLEYLDLSHNQLTTVP--AGLPRtLAILHLGRNRIRQVEAarLHGA 292
Cdd:COG4886  199 -EPLGNLTNLEELDLSGNQLTD--LPE-PLANLTNLETLDLSNNQLTDLPelGNLTN-LEELDLSNNQLTDLPP--LANL 271

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 768004117 293 RGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRAL 345
Cdd:COG4886  272 TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLL 324
LRR_8 pfam13855
Leucine rich repeat;
484-543 1.00e-07

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 1.00e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117  484 LEELHLEGNRIGHVGPEAFLSTPRLRALFLRANRLhmTSIAAEAFLGLPNLRVVDTAGNP 543
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGNR 60
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
217-489 2.51e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 96.54  E-value: 2.51e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 217 ALSRQTQLRELYLQHNQLTDSGLDattFSKLHSLEYLDLSHNQLTTVPAGLPR--TLAILHLGRNRIRQVEAArLHGARG 294
Cdd:COG4886  108 ELSNLTNLESLDLSGNQLTDLPEE---LANLTNLKELDLSNNQLTDLPEPLGNltNLKSLDLSNNQLTDLPEE-LGNLTN 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 295 LRYLLLQHNQLGSsgLPAgALRPLRGLHTLHLYGNGLDRVPPALPR--RLRALVLPHNHVAALgardlvatPGLTEL-NL 371
Cdd:COG4886  184 LKELDLSNNQITD--LPE-PLGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDL--------PELGNLtNL 252

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 372 AYnrlasarvhhrafrrlralrsLDLAGNQLTRLPMGLP-TGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLrvg 450
Cdd:COG4886  253 EE---------------------LDLSNNQLTDLPPLANlTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLL--- 308

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 768004117 451 dIGPGTWHELQALQMLDLSHNELSFVPPDLPEALEELHL 489
Cdd:COG4886  309 -NLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSL 346
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
223-510 4.22e-17

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 84.75  E-value: 4.22e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 223 QLRELYLQHNQLTdsgldaTTFSKLH-SLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVeAARLHGArgLRYLLLQ 301
Cdd:PRK15370 200 QITTLILDNNELK------SLPENLQgNIKTLYANSNQLTSIPATLPDTIQEMELSINRITEL-PERLPSA--LQSLDLF 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 302 HNQLgsSGLPAGAlrPlRGLHTLHLYGNGLDRVPPALPRrlralvlphnhvaalgardlvatpGLTELNlaynrlasarv 381
Cdd:PRK15370 271 HNKI--SCLPENL--P-EELRYLSVYDNSIRTLPAHLPS------------------------GITHLN----------- 310

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 382 hhrafrrlralrsldLAGNQLTRLPMGLPTGLRTLQLQRNQLRMLePEPLAglDQLRELSLAHNRLRV-GDIGPGTwhel 460
Cdd:PRK15370 311 ---------------VQSNSLTALPETLPPGLKTLEAGENALTSL-PASLP--PELQVLDVSKNQITVlPETLPPT---- 368

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 768004117 461 qaLQMLDLSHNELSFVPPDLPEALEELHLEGNRIGHVgPEaflSTPRLRA 510
Cdd:PRK15370 369 --ITTLDVSRNALTNLPENLPAALQIMQASRNNLVRL-PE---SLPHFRG 412
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
57-345 2.06e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.19  E-value: 2.06e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117  57 TVDCDGLDLRVFPDNITRAA--QHLSLQNNQLQELPyNELSRLSGLRTLNLHNNLISsealsgpsvsapvppcrgsgcqp 134
Cdd:COG4886  117 SLDLSGNQLTDLPEELANLTnlKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLT----------------------- 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 135 sdgDLPPHLWGeagtqvrvppqqpaeqrwpaprrLPRLRGHrhpqplqqpaqlpaaqpaaltraappagSPANNLISKVP 214
Cdd:COG4886  173 ---DLPEELGN-----------------------LTNLKEL----------------------------DLSNNQITDLP 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 215 rGALSRQTQLRELYLQHNQLTDsgLDAtTFSKLHSLEYLDLSHNQLTTVP--AGLPRtLAILHLGRNRIRQVEAarLHGA 292
Cdd:COG4886  199 -EPLGNLTNLEELDLSGNQLTD--LPE-PLANLTNLETLDLSNNQLTDLPelGNLTN-LEELDLSNNQLTDLPP--LANL 271

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 768004117 293 RGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRAL 345
Cdd:COG4886  272 TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLL 324
LRR_8 pfam13855
Leucine rich repeat;
411-473 3.67e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.61  E-value: 3.67e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 768004117  411 TGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVgdIGPGTWHELQALQMLDLSHNEL 473
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 216-380 5.39e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 56.72  E-value: 5.39e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 216 GALSRQTQLRELYLQHNQLTD-SGLDAttfskLHSLEYLDLSHNQLTTVP--AGLPRtLAILHLGRNRIRQVEAarLHGA 292
Cdd:cd21340   18 DNLSLCKNLKVLYLYDNKITKiENLEF-----LTNLTHLYLQNNQIEKIEnlENLVN-LKKLYLGGNRISVVEG--LENL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 293 RGLRYLLLQHNQlgssgLPAG--------ALRPLRG-LHTLHLYGNGLDRVPPALP-RRLRALVLPHNHVAALGA-RDLV 361
Cdd:cd21340   90 TNLEELHIENQR-----LPPGekltfdprSLAALSNsLRVLNISGNNIDSLEPLAPlRNLEQLDASNNQISDLEElLDLL 164

                        170       180
                 ....*....|....*....|
gi 768004117 362 AT-PGLTELNLAYNRLASAR 380
Cdd:cd21340  165 SSwPSLRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
484-543 1.00e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 1.00e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117  484 LEELHLEGNRIGHVGPEAFLSTPRLRALFLRANRLhmTSIAAEAFLGLPNLRVVDTAGNP 543
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGNR 60
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 77-112 4.51e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.30  E-value: 4.51e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 768004117   77 QHLSLQNNQLQELPynELSRLSGLRTLNL-HNNLISS 112
Cdd:pfam12799   4 EVLDLSNNQITDIP--PLAKLPNLETLDLsGNNKITD 38
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
217-489 2.51e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 96.54  E-value: 2.51e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 217 ALSRQTQLRELYLQHNQLTDSGLDattFSKLHSLEYLDLSHNQLTTVPAGLPR--TLAILHLGRNRIRQVEAArLHGARG 294
Cdd:COG4886  108 ELSNLTNLESLDLSGNQLTDLPEE---LANLTNLKELDLSNNQLTDLPEPLGNltNLKSLDLSNNQLTDLPEE-LGNLTN 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 295 LRYLLLQHNQLGSsgLPAgALRPLRGLHTLHLYGNGLDRVPPALPR--RLRALVLPHNHVAALgardlvatPGLTEL-NL 371
Cdd:COG4886  184 LKELDLSNNQITD--LPE-PLGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDL--------PELGNLtNL 252

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 372 AYnrlasarvhhrafrrlralrsLDLAGNQLTRLPMGLP-TGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLrvg 450
Cdd:COG4886  253 EE---------------------LDLSNNQLTDLPPLANlTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLL--- 308

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 768004117 451 dIGPGTWHELQALQMLDLSHNELSFVPPDLPEALEELHL 489
Cdd:COG4886  309 -NLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSL 346
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
207-554 9.08e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.84  E-value: 9.08e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 207 NNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLttvpaglprtlailhlgrnrirqvea 286
Cdd:COG4886   55 LLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE-------------------------- 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 287 arLHGARGLRYLLLQHNQLGSsgLPAgALRPLRGLHTLHLYGNGLDRVPPALprrlralvlphnhvaalgardlvatPGL 366
Cdd:COG4886  109 --LSNLTNLESLDLSGNQLTD--LPE-ELANLTNLKELDLSNNQLTDLPEPL-------------------------GNL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 367 TELNlaynrlasarvhhrafrrlralrSLDLAGNQLTRLPMGLP--TGLRTLQLQRNQLRMLePEPLAGLDQLRELSLAH 444
Cdd:COG4886  159 TNLK-----------------------SLDLSNNQLTDLPEELGnlTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSG 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 445 NRLRvgDIgPGTWHELQALQMLDLSHNELSfvppDLPE-----ALEELHLEGNRIGHVGPEAFLstPRLRALFLRANRLH 519
Cdd:COG4886  215 NQLT--DL-PEPLANLTNLETLDLSNNQLT----DLPElgnltNLEELDLSNNQLTDLPPLANL--TNLKTLDLSNNQLT 285

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 768004117 520 MTSIAAEAFLGLPNLRVVDTAGNPEQVLIRLPPTT 554
Cdd:COG4886  286 DLKLKELELLLGLNSLLLLLLLLNLLELLILLLLL 320
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
223-510 4.22e-17

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 84.75  E-value: 4.22e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 223 QLRELYLQHNQLTdsgldaTTFSKLH-SLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVeAARLHGArgLRYLLLQ 301
Cdd:PRK15370 200 QITTLILDNNELK------SLPENLQgNIKTLYANSNQLTSIPATLPDTIQEMELSINRITEL-PERLPSA--LQSLDLF 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 302 HNQLgsSGLPAGAlrPlRGLHTLHLYGNGLDRVPPALPRrlralvlphnhvaalgardlvatpGLTELNlaynrlasarv 381
Cdd:PRK15370 271 HNKI--SCLPENL--P-EELRYLSVYDNSIRTLPAHLPS------------------------GITHLN----------- 310

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 382 hhrafrrlralrsldLAGNQLTRLPMGLPTGLRTLQLQRNQLRMLePEPLAglDQLRELSLAHNRLRV-GDIGPGTwhel 460
Cdd:PRK15370 311 ---------------VQSNSLTALPETLPPGLKTLEAGENALTSL-PASLP--PELQVLDVSKNQITVlPETLPPT---- 368

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 768004117 461 qaLQMLDLSHNELSFVPPDLPEALEELHLEGNRIGHVgPEaflSTPRLRA 510
Cdd:PRK15370 369 --ITTLDVSRNALTNLPENLPAALQIMQASRNNLVRL-PE---SLPHFRG 412
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 206-518 1.70e-15

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 79.89  E-value: 1.70e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 206 ANNLISKVPRgALSRQTQLRELYLQHNQLtdSGLDATTFSKLHSLEYLDLSHNQLT-TVPAGLP--RTLAILHLGRNRIR 282
Cdd:PLN00113 197 SNQLVGQIPR-ELGQMKSLKWIYLGYNNL--SGEIPYEIGGLTSLNHLDLVYNNLTgPIPSSLGnlKNLQYLFLYQNKLS 273

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 283 QVEAARLHGARGLRYLLLQHNQLgsSGLPAGALRPLRGLHTLHLYGNGLD-RVPPALPR--RLRALVLPHNHVAALGARD 359
Cdd:PLN00113 274 GPIPPSIFSLQKLISLDLSDNSL--SGEIPELVIQLQNLEILHLFSNNFTgKIPVALTSlpRLQVLQLWSNKFSGEIPKN 351

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 360 LVATPGLTELNLAYNRLaSARVHHRAFRRLRALrSLDLAGNQL-TRLPMGLPT--GLRTLQLQRNQLRMLEPEPLAGLDQ 436
Cdd:PLN00113 352 LGKHNNLTVLDLSTNNL-TGEIPEGLCSSGNLF-KLILFSNSLeGEIPKSLGAcrSLRRVRLQDNSFSGELPSEFTKLPL 429

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 437 LRELSLAHNRLRvGDIGPGTWhELQALQMLDLSHNELSFVPPDL--PEALEELHLEGNRIGHVGPEAFLSTPRLRALFLR 514
Cdd:PLN00113 430 VYFLDISNNNLQ-GRINSRKW-DMPSLQMLSLARNKFFGGLPDSfgSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLS 507


                 ....
gi 768004117 515 ANRL 518
Cdd:PLN00113 508 ENKL 511
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
207-437 1.00e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.51  E-value: 1.00e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 207 NNLISKVPRgALSRQTQLRELYLQHNQLTDSGldaTTFSKLHSLEYLDLSHNQLTTVPAGLPR--TLAILHLGRNRIRQV 284
Cdd:COG4886  168 NNQLTDLPE-ELGNLTNLKELDLSNNQITDLP---EPLGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDL 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 285 EAarLHGARGLRYLLLQHNQLgsSGLPagALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVAALGARDLVATP 364
Cdd:COG4886  244 PE--LGNLTNLEELDLSNNQL--TDLP--PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILL 317

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 768004117 365 GLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQL 437
Cdd:COG4886  318 LLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLL 390
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
253-563 1.06e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 73.96  E-value: 1.06e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 253 LDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVeAARLHGarglrylllqhnqlgssglpagalrplrGLHTLHLYGNGLD 332
Cdd:PRK15370 183 LRLKILGLTTIPACIPEQITTLILDNNELKSL-PENLQG----------------------------NIKTLYANSNQLT 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 333 RVPPALPRRLRALVLPHNHVaalgardlvatpglTELNlayNRLASArvhhrafrrlraLRSLDLAGNQLTRLPMGLPTG 412
Cdd:PRK15370 234 SIPATLPDTIQEMELSINRI--------------TELP---ERLPSA------------LQSLDLFHNKISCLPENLPEE 284

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 413 LRTLQLQRNQLRMLePEPLAglDQLRELSLAHNRLRV--GDIGPGtwhelqaLQMLDLSHNELSFVPPDLPEALEELHLE 490
Cdd:PRK15370 285 LRYLSVYDNSIRTL-PAHLP--SGITHLNVQSNSLTAlpETLPPG-------LKTLEAGENALTSLPASLPPELQVLDVS 354

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 768004117 491 GNRIGhVGPEAFlsTPRLRALFLRANrlhmtsiaaeAFLGLPN-----LRVVDTAGNPeqvLIRLPPTTPRGpRAGGP 563
Cdd:PRK15370 355 KNQIT-VLPETL--PPTITTLDVSRN----------ALTNLPEnlpaaLQIMQASRNN---LVRLPESLPHF-RGEGP 415
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
57-345 2.06e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.19  E-value: 2.06e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117  57 TVDCDGLDLRVFPDNITRAA--QHLSLQNNQLQELPyNELSRLSGLRTLNLHNNLISsealsgpsvsapvppcrgsgcqp 134
Cdd:COG4886  117 SLDLSGNQLTDLPEELANLTnlKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLT----------------------- 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 135 sdgDLPPHLWGeagtqvrvppqqpaeqrwpaprrLPRLRGHrhpqplqqpaqlpaaqpaaltraappagSPANNLISKVP 214
Cdd:COG4886  173 ---DLPEELGN-----------------------LTNLKEL----------------------------DLSNNQITDLP 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 215 rGALSRQTQLRELYLQHNQLTDsgLDAtTFSKLHSLEYLDLSHNQLTTVP--AGLPRtLAILHLGRNRIRQVEAarLHGA 292
Cdd:COG4886  199 -EPLGNLTNLEELDLSGNQLTD--LPE-PLANLTNLETLDLSNNQLTDLPelGNLTN-LEELDLSNNQLTDLPP--LANL 271

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 768004117 293 RGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRAL 345
Cdd:COG4886  272 TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLL 324
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 207-492 5.28e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 68.72  E-value: 5.28e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 207 NNLISKVPrGALSRQTQLRELYLQHNQLTDS------------GLDATTFS----------KLHSLEYLDLSHNQLT-TV 263
Cdd:PLN00113 246 NNLTGPIP-SSLGNLKNLQYLFLYQNKLSGPippsifslqkliSLDLSDNSlsgeipelviQLQNLEILHLFSNNFTgKI 324

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 264 PAG---LPRtLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLgSSGLPAGALRPLRgLHTLHLYGNGLD-RVPPALP 339
Cdd:PLN00113 325 PVAltsLPR-LQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNL-TGEIPEGLCSSGN-LFKLILFSNSLEgEIPKSLG 401

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 340 --RRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLaSARVHHRA----------------------FRRLRALRSL 395
Cdd:PLN00113 402 acRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNL-QGRINSRKwdmpslqmlslarnkffgglpdSFGSKRLENL 480

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 396 DLAGNQLT-RLPMGLPT--GLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRvGDIgPGTWHELQALQMLDLSHNE 472
Cdd:PLN00113 481 DLSRNQFSgAVPRKLGSlsELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLS-GQI-PASFSEMPVLSQLDLSQNQ 558

                        330       340
                 ....*....|....*....|...
gi 768004117 473 LSF-VPPDLP--EALEELHLEGN 492
Cdd:PLN00113 559 LSGeIPKNLGnvESLVQVNISHN 581
LRR_8 pfam13855
Leucine rich repeat;
411-473 3.67e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.61  E-value: 3.67e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 768004117  411 TGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVgdIGPGTWHELQALQMLDLSHNEL 473
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
57-329 1.20e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 60.33  E-value: 1.20e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117  57 TVDCDGLDLRVFPDNITRAA--QHLSLQNNQLQELPyNELSRLSGLRTLNLHNNLISsealsgpsvsapvppcrgsgcqp 134
Cdd:COG4886  140 ELDLSNNQLTDLPEPLGNLTnlKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQIT----------------------- 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 135 sdgDLPPHLwgeagtqvrvppqqpaeQRWPAPRRLpRLrghrhpqplqqpaqlpaaqpaaltraappagspANNLISKVP 214
Cdd:COG4886  196 ---DLPEPL-----------------GNLTNLEEL-DL---------------------------------SGNQLTDLP 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 215 RgALSRQTQLRELYLQHNQLTdsglDATTFSKLHSLEYLDLSHNQLTTVP--AGLPRtLAILHLGRNRIRQVEAARLHGA 292
Cdd:COG4886  222 E-PLANLTNLETLDLSNNQLT----DLPELGNLTNLEELDLSNNQLTDLPplANLTN-LKTLDLSNNQLTDLKLKELELL 295

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 768004117 293 RGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGN 329
Cdd:COG4886  296 LGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKG 332
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 217-376 1.39e-09

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 60.19  E-value: 1.39e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 217 ALSRQTQLRELYLQHNQLTDSGLD--ATTFSKLHSLEYLDLSHNQLTTvpAGL---------PRTLAILHLGRNRIrQVE 285
Cdd:COG5238  203 ALTQNTTVTTLWLKRNPIGDEGAEilAEALKGNKSLTTLDLSNNQIGD--EGVialaealknNTTVETLYLSGNQI-GAE 279

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 286 AAR-----LHGARGLRYLLLQHNQLGSSGLPAGA--LRPLRGLHTLHLYGNGLD-----RVPPALP--RRLRALVLPHNH 351
Cdd:COG5238  280 GAIalakaLQGNTTLTSLDLSVNRIGDEGAIALAegLQGNKTLHTLNLAYNGIGaqgaiALAKALQenTTLHSLDLSDNQ 359

                        170       180
                 ....*....|....*....|....*....
gi 768004117 352 VAALGARDL----VATPGLTELNLAYNRL 376
Cdd:COG5238  360 IGDEGAIALakylEGNTTLRELNLGKNNI 388
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 224-518 3.51e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.86  E-value: 3.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 224 LRELYLQHNQLTdSGLDATTFSKLHSLEYLDLSHNQLT-TVPAGLPRTLAILHLGRNRIRqveaarlhgarGLRYlllqh 302
Cdd:PLN00113  95 IQTINLSNNQLS-GPIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLSNNMLS-----------GEIP----- 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 303 NQLGSsglpagalrpLRGLHTLHLYGNGL-DRVPPALPR--RLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASA 379
Cdd:PLN00113 158 NDIGS----------FSSLKVLDLGGNVLvGKIPNSLTNltSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGE 227

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 380 rvhhrafrrlralrsldlAGNQLTRLpmglpTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLrVGDIGPGTWhE 459
Cdd:PLN00113 228 ------------------IPYEIGGL-----TSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKL-SGPIPPSIF-S 282

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 768004117 460 LQALQMLDLSHNELSFVPPDLP---EALEELHLEGNRIGHVGPEAFLSTPRLRALFLRANRL 518
Cdd:PLN00113 283 LQKLISLDLSDNSLSGEIPELViqlQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKF 344
LRR_8 pfam13855
Leucine rich repeat;
222-281 3.73e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.91  E-value: 3.73e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 768004117  222 TQLRELYLQHNQLTDsgLDATTFSKLHSLEYLDLSHNQLTTVP----AGLPRtLAILHLGRNRI 281
Cdd:pfam13855   1 PNLRSLDLSNNRLTS--LDDGAFKGLSNLKVLDLSNNLLTTLSpgafSGLPS-LRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 216-380 5.39e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 56.72  E-value: 5.39e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 216 GALSRQTQLRELYLQHNQLTD-SGLDAttfskLHSLEYLDLSHNQLTTVP--AGLPRtLAILHLGRNRIRQVEAarLHGA 292
Cdd:cd21340   18 DNLSLCKNLKVLYLYDNKITKiENLEF-----LTNLTHLYLQNNQIEKIEnlENLVN-LKKLYLGGNRISVVEG--LENL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 293 RGLRYLLLQHNQlgssgLPAG--------ALRPLRG-LHTLHLYGNGLDRVPPALP-RRLRALVLPHNHVAALGA-RDLV 361
Cdd:cd21340   90 TNLEELHIENQR-----LPPGekltfdprSLAALSNsLRVLNISGNNIDSLEPLAPlRNLEQLDASNNQISDLEElLDLL 164

                        170       180
                 ....*....|....*....|
gi 768004117 362 AT-PGLTELNLAYNRLASAR 380
Cdd:cd21340  165 SSwPSLRELDLTGNPVCKKP 184
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 395-543 1.18e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.56  E-value: 1.18e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 395 LDLAGNQLTRLPmGLP--TGLRTLQLQRNQLRMLEPepLAGLDQLRELSLAHNRLRV--GdigpgtWHELQALQMLDLSH 470
Cdd:cd21340   29 LYLYDNKITKIE-NLEflTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVveG------LENLTNLEELHIEN 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 471 NELsfvPPDLP------------EALEELHLEGNRIGHVGPEAFLStpRLRALFLRANRLHMTSIAAEAFLGLPNLRVVD 538
Cdd:cd21340  100 QRL---PPGEKltfdprslaalsNSLRVLNISGNNIDSLEPLAPLR--NLEQLDASNNQISDLEELLDLLSSWPSLRELD 174


                 ....*
gi 768004117 539 TAGNP 543
Cdd:cd21340  175 LTGNP 179
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 217-376 1.78e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 56.21  E-value: 1.78e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 217 ALSRQTQLRELYLQHNQLTDSGLD---ATTFSKLHSLEYLDLSHNQLTTVPA-----GLP--RTLAILHLGRNRIRQVEA 286
Cdd:cd00116  103 SLLRSSSLQELKLNNNGLGDRGLRllaKGLKDLPPALEKLVLGRNRLEGASCealakALRanRDLKELNLANNGIGDAGI 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 287 ARLhgARG------LRYLLLQHNQLGSSG--LPAGALRPLRGLHTLHLYGNGLDRVP--------PALPRRLRALVLPHN 350
Cdd:cd00116  183 RAL--AEGlkancnLEVLDLNNNGLTDEGasALAETLASLKSLEVLNLGDNNLTDAGaaalasalLSPNISLLTLSLSCN 260

                        170       180       190
                 ....*....|....*....|....*....|
gi 768004117 351 HVAALGARDLV----ATPGLTELNLAYNRL 376
Cdd:cd00116  261 DITDDGAKDLAevlaEKESLLELDLRGNKF 290
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 247-471 1.83e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.18  E-value: 1.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 247 LHSLEYLDLSHNQLTTVPA-GLPRTLAILHLGRNRIRQVEAarLHGARGLRYLLLQHNQLgssglpagalRPLRGLHTLh 325
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNlSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQI----------EKIENLENL- 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 326 lygngldrvppalpRRLRALVLPHNHVAAL-GARDLvatPGLTELNLAYNRLASarvhhrafrrlralrsldlaGNQLT- 403
Cdd:cd21340   68 --------------VNLKKLYLGGNRISVVeGLENL---TNLEELHIENQRLPP--------------------GEKLTf 110

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 768004117 404 --RLPMGLPTGLRTLQLQRNQLRmlEPEPLAGLDQLRELSLAHNRLR-VGDIGP--GTWHELQAlqmLDLSHN 471
Cdd:cd21340  111 dpRSLAALSNSLRVLNISGNNID--SLEPLAPLRNLEQLDASNNQISdLEELLDllSSWPSLRE---LDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
207-260 2.98e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.22  E-value: 2.98e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 768004117  207 NNLISKVPRGALSRQTQLRELYLQHNQLTdsGLDATTFSKLHSLEYLDLSHNQL 260
Cdd:pfam13855  10 NNRLTSLDDGAFKGLSNLKVLDLSNNLLT--TLSPGAFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
253-535 3.72e-08

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 56.32  E-value: 3.72e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 253 LDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEAArlhgARGLRYLLLQHNQLGSsgLPAgaLRPlrGLHTLHLYGNGLD 332
Cdd:PRK15387 206 LNVGESGLTTLPDCLPAHITTLVIPDNNLTSLPAL----PPELRTLEVSGNQLTS--LPV--LPP--GLLELSIFSNPLT 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 333 RVPpALPRRLRALVLPHNHVAALGardlVATPGLTELNLAYNRLASarvhhrAFRRLRALRSLDLAGNQLTRLPMgLPTG 412
Cdd:PRK15387 276 HLP-ALPSGLCKLWIFGNQLTSLP----VLPPGLQELSVSDNQLAS------LPALPSELCKLWAYNNQLTSLPT-LPSG 343

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 413 LRTLQLQRNQLRMLEPEPlaglDQLRELSLAHNRLRVgdigpgtwhelqalqmldlshnelsfvPPDLPEALEELHLEGN 492
Cdd:PRK15387 344 LQELSVSDNQLASLPTLP----SELYKLWAYNNRLTS---------------------------LPALPSGLKELIVSGN 392

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 768004117 493 RIGHVGpeafLSTPRLRALFLRANRLHMTSIAAEAFLGLPNLR 535
Cdd:PRK15387 393 RLTSLP----VLPSELKELMVSGNRLTSLPMLPSGLLSLSVYR 431
LRR_8 pfam13855
Leucine rich repeat;
484-543 1.00e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 1.00e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117  484 LEELHLEGNRIGHVGPEAFLSTPRLRALFLRANRLhmTSIAAEAFLGLPNLRVVDTAGNP 543
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGNR 60
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
205-447 1.39e-07

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 54.40  E-value: 1.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 205 PANNLISkVPrgalSRQTQLRELYLQHNQLTDSGLDATtfsklhSLEYLDLSHNQLTTVPAgLPRTLAILHLGRNRIRQV 284
Cdd:PRK15387 230 PDNNLTS-LP----ALPPELRTLEVSGNQLTSLPVLPP------GLLELSIFSNPLTHLPA-LPSGLCKLWIFGNQLTSL 297

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 285 EAArlhgARGLRYLLLQHNQLGSsgLPAGALRplrgLHTLHLYGNGLDRVPpALPRRLRALVLPHNHVAALGA------- 357
Cdd:PRK15387 298 PVL----PPGLQELSVSDNQLAS--LPALPSE----LCKLWAYNNQLTSLP-TLPSGLQELSVSDNQLASLPTlpselyk 366

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 358 --------RDLVATP-GLTELNLAYNRLASARVhhrafrRLRALRSLDLAGNQLTRLPMgLPTGLRTLQLQRNQLRMLeP 428
Cdd:PRK15387 367 lwaynnrlTSLPALPsGLKELIVSGNRLTSLPV------LPSELKELMVSGNRLTSLPM-LPSGLLSLSVYRNQLTRL-P 438

                        250
                 ....*....|....*....
gi 768004117 429 EPLAGLDQLRELSLAHNRL 447
Cdd:PRK15387 439 ESLIHLSSETTVNLEGNPL 457
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 227-518 4.86e-07

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 52.48  E-value: 4.86e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 227 LYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPA-------GLPRTLAILHLGRNRI--RQVE--AARLHGARGL 295
Cdd:COG5238  159 LGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIeelaealTQNTTVTTLWLKRNPIgdEGAEilAEALKGNKSL 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 296 RYLLLQHNQLGSSGLP--AGALRPLRGLHTLHLYGNGLDrvppalprrlralvlpHNHVAALgARDLVATPGLTELNLAY 373
Cdd:COG5238  239 TTLDLSNNQIGDEGVIalAEALKNNTTVETLYLSGNQIG----------------AEGAIAL-AKALQGNTTLTSLDLSV 301

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 374 NRLASArvhhrafrrlralrsldlagnqltrlpmglptGLRTLQlqrnqlrmlepEPLAGLDQLRELSLAHNRlrvgdIG 453
Cdd:COG5238  302 NRIGDE--------------------------------GAIALA-----------EGLQGNKTLHTLNLAYNG-----IG 333

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 454 PGTWHEL-QALQM------LDLSHNELSFVPPD-LPEALE------ELHLEGNRIGHVGPEAF---LSTPRLRALFLRAN 516
Cdd:COG5238  334 AQGAIALaKALQEnttlhsLDLSDNQIGDEGAIaLAKYLEgnttlrELNLGKNNIGKQGAEALidaLQTNRLHTLILDGN 413


                 ..
gi 768004117 517 RL 518
Cdd:COG5238  414 LI 415
LRR_8 pfam13855
Leucine rich repeat;
463-518 1.25e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 1.25e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 768004117  463 LQMLDLSHNELSFVPPDL---PEALEELHLEGNRIGHVGPEAFLSTPRLRALFLRANRL 518
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAfkgLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 206-447 1.85e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.00  E-value: 1.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 206 ANNLISKVPRgALSRQTQLRELYLQHNQLtdSGLDATTFSKLHSLEYLDLSHNQLT-TVPAGLPRT--LAILHLGRNRIR 282
Cdd:PLN00113 317 SNNFTGKIPV-ALTSLPRLQVLQLWSNKF--SGEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSgnLFKLILFSNSLE 393

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 283 QVEAARLHGARGLRYLLLQHNQLgSSGLPAGALRpLRGLHTLHLYGNGL---------------------DRVPPALP-- 339
Cdd:PLN00113 394 GEIPKSLGACRSLRRVRLQDNSF-SGELPSEFTK-LPLVYFLDISNNNLqgrinsrkwdmpslqmlslarNKFFGGLPds 471

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 340 ---RRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASarVHHRAFRRLRALRSLDLAGNQLT-RLPMG---LPTg 412
Cdd:PLN00113 472 fgsKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSG--EIPDELSSCKKLVSLDLSHNQLSgQIPASfseMPV- 548

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 768004117 413 LRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRL 447
Cdd:PLN00113 549 LSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHL 583
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 222-262 8.52e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.92  E-value: 8.52e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 768004117  222 TQLRELYLQHNQLTDSGLdattFSKLHSLEYLDLSHNQLTT 262
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPP----LAKLPNLETLDLSGNNKIT 37
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 226-542 1.30e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 44.27  E-value: 1.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 226 ELYLQHNQLTDSGLdATTFSKLHSLEYLDLSHNQLTTVpaglprtlailhlgrnRIRQVeAARLHGARGLRYLLLQHNQL 305
Cdd:cd00116    2 QLSLKGELLKTERA-TELLPKLLCLQVLRLEGNTLGEE----------------AAKAL-ASALRPQPSLKELCLSLNET 63

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 306 GSS----GLPAGALRPLRGLHTLHLYGNGLDrvpPALPRRLRALVLphnhvaalgardlvaTPGLTELNLAYNRLAsarv 381
Cdd:cd00116   64 GRIprglQSLLQGLTKGCGLQELDLSDNALG---PDGCGVLESLLR---------------SSSLQELKLNNNGLG---- 121

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 382 hhrafrrlralrslDLAGNQLTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQ----LRELSLAHNRLRvgdiGPGTW 457
Cdd:cd00116  122 --------------DRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALAKALRanrdLKELNLANNGIG----DAGIR 183

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 458 H------ELQALQMLDLSHN--------ELSFVPPDLPeALEELHLEGNRIGHVGPEAFLSTPRLRALFLRANRLHMTSI 523
Cdd:cd00116  184 AlaeglkANCNLEVLDLNNNgltdegasALAETLASLK-SLEVLNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDI 262

                        330       340
                 ....*....|....*....|....*.
gi 768004117 524 AAEAFLGL-------PNLRVVDTAGN 542
Cdd:cd00116  263 TDDGAKDLaevlaekESLLELDLRGN 288
LRR_8 pfam13855
Leucine rich repeat;
269-331 1.37e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 1.37e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 768004117  269 RTLAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQLgsSGLPAGALRPLRGLHTLHLYGNGL 331
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 401-543 2.48e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.50  E-value: 2.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 401 QLTRLPMGLPT--GLRTLQLQRNQLRMLEPEPLAGLDQ---LRELSLAHNRL--RVGDIGPGTWHELQ-ALQMLDLSHNE 472
Cdd:cd00116   69 GLQSLLQGLTKgcGLQELDLSDNALGPDGCGVLESLLRsssLQELKLNNNGLgdRGLRLLAKGLKDLPpALEKLVLGRNR 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 473 LSFVP-PDLPEA------LEELHLEGNRIGHVG----PEAFLSTPRLRALFLRANRLHMT--SIAAEAFLGLPNLRVVDT 539
Cdd:cd00116  149 LEGAScEALAKAlranrdLKELNLANNGIGDAGiralAEGLKANCNLEVLDLNNNGLTDEgaSALAETLASLKSLEVLNL 228


                 ....
gi 768004117 540 AGNP 543
Cdd:cd00116  229 GDNN 232
PLN03150 PLN03150
hypothetical protein; Provisional
 416-535 3.77e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.27  E-value: 3.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768004117 416 LQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRvGDIgPGTWHELQALQMLDLSHNELS-FVPPDLPE--ALEELHLEGN 492
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIR-GNI-PPSLGSITSLEVLDLSYNSFNgSIPESLGQltSLRILNLNGN 500

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 768004117 493 RIGHVGPEAflstprLRALFLRANRLHMTSIAaeAFLGLPNLR 535
Cdd:PLN03150 501 SLSGRVPAA------LGGRLLHRASFNFTDNA--GLCGIPGLR 535
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-112 1.38e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.46  E-value: 1.38e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 768004117  50 CSCPRVDTVDCDGLDLRVFPDNITRAA--QHLSLQNNQLQELPynELSRLSGLRTLNLHNNLISS 112
Cdd:COG4886  202 GNLTNLEELDLSGNQLTDLPEPLANLTnlETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTD 264
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 77-112 4.51e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.30  E-value: 4.51e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 768004117   77 QHLSLQNNQLQELPynELSRLSGLRTLNL-HNNLISS 112
Cdd:pfam12799   4 EVLDLSNNQITDIP--PLAKLPNLETLDLsGNNKITD 38
LRR_8 pfam13855
Leucine rich repeat;
77-110 5.90e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.19  E-value: 5.90e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 768004117   77 QHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLI 110
Cdd:pfam13855  28 KVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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