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Conserved domains on  [gi|767979685|ref|XP_011534719|]
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tubulin polymerization-promoting protein family member 2 isoform X3 [Homo sapiens]

Protein Classification

tubulin polymerization-promoting family protein( domain architecture ID 10527554)

tubulin polymerization-promoting family protein similar to human tubulin polymerization-promoting protein (TPPP), a regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath

CATH:  1.10.238.10
EC:  3.6.5.-
Gene Ontology:  GO:0015631|GO:0046785|GO:0001578|GO:0000226
PubMed:  17105200
SCOP:  4001297

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
p25-alpha pfam05517
p25-alpha; This family encodes a 25 kDa protein that is phosphorylated by a Ser/Thr-Pro kinase. ...
 6-109 9.50e-51

p25-alpha; This family encodes a 25 kDa protein that is phosphorylated by a Ser/Thr-Pro kinase. It has been described as a brain specific protein, but it is found in Tetrahymena thermophila.


:

Pssm-ID: 461670  Cd Length: 155  Bit Score: 157.81  E-value: 9.50e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979685    6 EKTFHRFAAFGESSSSGTEMNNKNFSKLCKDCGIMDgKTVTSTDVDIVFSKVKAKNARTITFQQFKEAVKELGQKRFKGK 85
Cdd:pfam05517   1 EEAFKAFAKFGDTKATGKEMDGKNFSKLCKDCGVID-KKVTSTDVDIIFSKVKAKSARTITFEQFKEALEELAEKRFKKK 79

                          90       100
                  ....*....|....*....|....
gi 767979685   86 SPDEVLENIYGLMEGKDPATTGAT 109
Cdd:pfam05517  80 VKEEELELIEKLIEGKGPATTGVT 103
 
Name Accession Description Interval E-value
p25-alpha pfam05517
p25-alpha; This family encodes a 25 kDa protein that is phosphorylated by a Ser/Thr-Pro kinase. ...
 6-109 9.50e-51

p25-alpha; This family encodes a 25 kDa protein that is phosphorylated by a Ser/Thr-Pro kinase. It has been described as a brain specific protein, but it is found in Tetrahymena thermophila.


Pssm-ID: 461670  Cd Length: 155  Bit Score: 157.81  E-value: 9.50e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979685    6 EKTFHRFAAFGESSSSGTEMNNKNFSKLCKDCGIMDgKTVTSTDVDIVFSKVKAKNARTITFQQFKEAVKELGQKRFKGK 85
Cdd:pfam05517   1 EEAFKAFAKFGDTKATGKEMDGKNFSKLCKDCGVID-KKVTSTDVDIIFSKVKAKSARTITFEQFKEALEELAEKRFKKK 79

                          90       100
                  ....*....|....*....|....
gi 767979685   86 SPDEVLENIYGLMEGKDPATTGAT 109
Cdd:pfam05517  80 VKEEELELIEKLIEGKGPATTGVT 103
 
Name Accession Description Interval E-value
p25-alpha pfam05517
p25-alpha; This family encodes a 25 kDa protein that is phosphorylated by a Ser/Thr-Pro kinase. ...
 6-109 9.50e-51

p25-alpha; This family encodes a 25 kDa protein that is phosphorylated by a Ser/Thr-Pro kinase. It has been described as a brain specific protein, but it is found in Tetrahymena thermophila.


Pssm-ID: 461670  Cd Length: 155  Bit Score: 157.81  E-value: 9.50e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767979685    6 EKTFHRFAAFGESSSSGTEMNNKNFSKLCKDCGIMDgKTVTSTDVDIVFSKVKAKNARTITFQQFKEAVKELGQKRFKGK 85
Cdd:pfam05517   1 EEAFKAFAKFGDTKATGKEMDGKNFSKLCKDCGVID-KKVTSTDVDIIFSKVKAKSARTITFEQFKEALEELAEKRFKKK 79

                          90       100
                  ....*....|....*....|....
gi 767979685   86 SPDEVLENIYGLMEGKDPATTGAT 109
Cdd:pfam05517  80 VKEEELELIEKLIEGKGPATTGVT 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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