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heat shock protein HSP 90-alpha isoform X1 [Homo sapiens]
Protein Classification
HSP90 family protein ( domain architecture ID 1903338 )
HSP90 (heat shock protein 90) family protein functions as a molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved in cell cycle control and signal transduction
List of domain hits
Name
Accession
Description
Interval
E-value
HSP90 super family
cl46693 Hsp90 protein;
139-853
0e+00
Hsp90 protein;
PTZ00272 :Pssm-ID: 481033
Cd Length: 701
Bit Score: 959.52
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 139 ETFAFQAEI A QLMSLIINTFYSNKEIFLRELISN S SDA L DKIRY E SLTDPS K L DSGKE L H I NLI P N K QDR TLT IV D T GIG 218
Cdd:PTZ00272 3 ETFAFQAEI N QLMSLIINTFYSNKEIFLRELISN A SDA C DKIRY Q SLTDPS V L GESPR L C I RVV P D K ENK TLT VE D N GIG 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 219 MTKADL I NNLGTIA K SGTKAFMEAL Q AG A D I SMIGQFGVGFYSAYLVA EK VTV IT K H N D DE Q Y A WESSAGG S FT VRTDTG 298
Cdd:PTZ00272 83 MTKADL V NNLGTIA R SGTKAFMEAL E AG G D M SMIGQFGVGFYSAYLVA DR VTV TS K N N S DE S Y V WESSAGG T FT ITSTPE 162
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 299 EP M G RGT KVI LHLKEDQ T EYLE E RR I KE IV KKHS Q FIGY P I T L F VEK ERD KEV S D DEA E EKEDKE E EK E KEE kesedkpe 378
Cdd:PTZ00272 163 SD M K RGT RIT LHLKEDQ M EYLE P RR L KE LI KKHS E FIGY D I E L M VEK TTE KEV T D EDE E DTKKAD E DG E EPK -------- 234
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 379 I E D V gs D E EE E K K DGDK KK K K KIKEK Y ID Q eel NK T KP I WTR N P D D I T N EEY GE FYK SLT NDWED HL A V KHFSVEGQLEF 458
Cdd:PTZ00272 235 V E E V -- K E GD E G K KKKT KK V K EVTKE Y EV Q --- NK H KP L WTR D P K D V T K EEY AA FYK AIS NDWED PA A T KHFSVEGQLEF 309
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 459 R ALL FVP R RAPFD L FE NR KK K NNIKLYVRRVFIMDNCE E L I P EY L N F IR GVVDSEDLPLNISRE M LQQ S KILKVIRKN L V 538
Cdd:PTZ00272 310 R SIM FVP K RAPFD M FE PN KK R NNIKLYVRRVFIMDNCE D L C P DW L G F VK GVVDSEDLPLNISRE N LQQ N KILKVIRKN I V 389
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 539 KKCLE L F T E L AE D KE N YK K FYEQF S KNIKLGIHED SQ NRKKL S ELLR Y Y TSA SG D EM VS LKDY C TRMK EN QK H IYYITG E 618
Cdd:PTZ00272 390 KKCLE M F D E V AE N KE D YK Q FYEQF G KNIKLGIHED TA NRKKL M ELLR F Y STE SG E EM TT LKDY V TRMK AG QK S IYYITG D 469
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 619 T K DQVAN S A F V E RL R KH GLEV IY M I EPIDEY CV QQ L K E FE G K TLVSV TKEG LELP E D EEEK KKQ EE K K TKF E N LCK I MK D 698
Cdd:PTZ00272 470 S K KKLET S P F I E QA R RR GLEV LF M T EPIDEY VM QQ V K D FE D K KFACL TKEG VHFE E S EEEK QQR EE E K AAC E K LCK T MK E 549
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 699 I L EK KVEKV V VS N RL V TSPC CI VTS TY GW T A N ME R IM KA QALRD N S TMG YM AA KK HL E I NP D H S II ET LR QKAE AD K NDK 778
Cdd:PTZ00272 550 V L GD KVEKV I VS E RL S TSPC IL VTS EF GW S A H ME Q IM RN QALRD S S MAQ YM MS KK TM E L NP R H P II KE LR RRVG AD E NDK 629
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767980445 779 S VKDLV I LL YE T A LL S SGF S LEDP QTH A N RI Y RMIKLGL GI DE DD pta DDTSA A VTE E MP P L E GDDD TS R ME E VD 853
Cdd:PTZ00272 630 A VKDLV F LL FD T S LL T SGF Q LEDP TGY A E RI N RMIKLGL SL DE EE --- EEAAE A PVA E TA P A E VTAG TS S ME Q VD 701
Name
Accession
Description
Interval
E-value
PTZ00272
PTZ00272 heat shock protein 83 kDa (Hsp83); Provisional
139-853
0e+00
heat shock protein 83 kDa (Hsp83); Provisional
Pssm-ID: 240341
Cd Length: 701
Bit Score: 959.52
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 139 ETFAFQAEI A QLMSLIINTFYSNKEIFLRELISN S SDA L DKIRY E SLTDPS K L DSGKE L H I NLI P N K QDR TLT IV D T GIG 218
Cdd:PTZ00272 3 ETFAFQAEI N QLMSLIINTFYSNKEIFLRELISN A SDA C DKIRY Q SLTDPS V L GESPR L C I RVV P D K ENK TLT VE D N GIG 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 219 MTKADL I NNLGTIA K SGTKAFMEAL Q AG A D I SMIGQFGVGFYSAYLVA EK VTV IT K H N D DE Q Y A WESSAGG S FT VRTDTG 298
Cdd:PTZ00272 83 MTKADL V NNLGTIA R SGTKAFMEAL E AG G D M SMIGQFGVGFYSAYLVA DR VTV TS K N N S DE S Y V WESSAGG T FT ITSTPE 162
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 299 EP M G RGT KVI LHLKEDQ T EYLE E RR I KE IV KKHS Q FIGY P I T L F VEK ERD KEV S D DEA E EKEDKE E EK E KEE kesedkpe 378
Cdd:PTZ00272 163 SD M K RGT RIT LHLKEDQ M EYLE P RR L KE LI KKHS E FIGY D I E L M VEK TTE KEV T D EDE E DTKKAD E DG E EPK -------- 234
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 379 I E D V gs D E EE E K K DGDK KK K K KIKEK Y ID Q eel NK T KP I WTR N P D D I T N EEY GE FYK SLT NDWED HL A V KHFSVEGQLEF 458
Cdd:PTZ00272 235 V E E V -- K E GD E G K KKKT KK V K EVTKE Y EV Q --- NK H KP L WTR D P K D V T K EEY AA FYK AIS NDWED PA A T KHFSVEGQLEF 309
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 459 R ALL FVP R RAPFD L FE NR KK K NNIKLYVRRVFIMDNCE E L I P EY L N F IR GVVDSEDLPLNISRE M LQQ S KILKVIRKN L V 538
Cdd:PTZ00272 310 R SIM FVP K RAPFD M FE PN KK R NNIKLYVRRVFIMDNCE D L C P DW L G F VK GVVDSEDLPLNISRE N LQQ N KILKVIRKN I V 389
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 539 KKCLE L F T E L AE D KE N YK K FYEQF S KNIKLGIHED SQ NRKKL S ELLR Y Y TSA SG D EM VS LKDY C TRMK EN QK H IYYITG E 618
Cdd:PTZ00272 390 KKCLE M F D E V AE N KE D YK Q FYEQF G KNIKLGIHED TA NRKKL M ELLR F Y STE SG E EM TT LKDY V TRMK AG QK S IYYITG D 469
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 619 T K DQVAN S A F V E RL R KH GLEV IY M I EPIDEY CV QQ L K E FE G K TLVSV TKEG LELP E D EEEK KKQ EE K K TKF E N LCK I MK D 698
Cdd:PTZ00272 470 S K KKLET S P F I E QA R RR GLEV LF M T EPIDEY VM QQ V K D FE D K KFACL TKEG VHFE E S EEEK QQR EE E K AAC E K LCK T MK E 549
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 699 I L EK KVEKV V VS N RL V TSPC CI VTS TY GW T A N ME R IM KA QALRD N S TMG YM AA KK HL E I NP D H S II ET LR QKAE AD K NDK 778
Cdd:PTZ00272 550 V L GD KVEKV I VS E RL S TSPC IL VTS EF GW S A H ME Q IM RN QALRD S S MAQ YM MS KK TM E L NP R H P II KE LR RRVG AD E NDK 629
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767980445 779 S VKDLV I LL YE T A LL S SGF S LEDP QTH A N RI Y RMIKLGL GI DE DD pta DDTSA A VTE E MP P L E GDDD TS R ME E VD 853
Cdd:PTZ00272 630 A VKDLV F LL FD T S LL T SGF Q LEDP TGY A E RI N RMIKLGL SL DE EE --- EEAAE A PVA E TA P A E VTAG TS S ME Q VD 701
HSP90
pfam00183 Hsp90 protein;
317-841
0e+00
Hsp90 protein;
Pssm-ID: 459703
Cd Length: 516
Bit Score: 838.75
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 317 EYLEE RR IKE I VKK H S Q FI GY PI T L F VEKE RDK EV S D D E A EE K E DK EEE KEKEE K esedkpe I E DVG sdeeeek KDGD KK 396
Cdd:pfam00183 1 EYLEE KK IKE L VKK Y S E FI NF PI Y L W VEKE EEV EV P D E E E EE E E EE EEE EDDDP K ------- V E EED ------- EEEE KK 66
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 397 K K KK I KE KYIDQ E E LNKTKPIWTRNP DDI T N EEY G EFYKSL TN DWED H LAVKHFSVEG QL EF RA LLF V P R RAPFDLFEN R 476
Cdd:pfam00183 67 K T KK V KE TVWEW E L LNKTKPIWTRNP KEV T E EEY A EFYKSL SK DWED P LAVKHFSVEG EV EF KS LLF I P K RAPFDLFEN K 146
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 477 KKKNNIKLYVRRVFI M D NC E E LIPEYLNF IR GVVDS E DLPLN I SRE M LQQ S KILKVI R K N LV K K C L EL F T E L AE D KE N YK 556
Cdd:pfam00183 147 KKKNNIKLYVRRVFI T D DF E D LIPEYLNF VK GVVDS D DLPLN V SRE T LQQ N KILKVI K K K LV R K A L DM F K E I AE E KE D YK 226
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 557 KF YEQ F S KN I KLGI H EDS Q NR K KL SE LLR Y Y T S A SGDE MV SL K DY CT RMKE N QKHIYYITGE T K DQ V A NS A F V ERL R K H G 636
Cdd:pfam00183 227 KF WKE F G KN L KLGI I EDS S NR N KL AK LLR F Y S S K SGDE LT SL D DY VS RMKE G QKHIYYITGE S K EE V E NS P F L ERL K K K G 306
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 637 L EV I Y MIE PIDEY C VQQLKEF E GK T LV S V T KEGLEL P EDEEEKKK Q EE K K TK FE N L C K IM KD I L EK KVEKVVVSNRLV T S 716
Cdd:pfam00183 307 Y EV L Y LTD PIDEY A VQQLKEF D GK K LV N V A KEGLEL E EDEEEKKK D EE L K KE FE P L T K WL KD V L GD KVEKVVVSNRLV D S 386
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 717 PC CI VTS T YGW T ANMERIMKAQALR - D N S TMG YM AA KK H LEINP D H S II ET L RQKA EADK N DK SV KDL VI LLYETALL S S 795
Cdd:pfam00183 387 PC VL VTS Q YGW S ANMERIMKAQALR k D S S MSS YM SS KK T LEINP R H P II KE L LKRV EADK D DK TA KDL AL LLYETALL R S 466
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|
gi 767980445 796 GFSLEDP QTH A N RIYRM I KLGLGIDED DPTADD ---- TSAAVT EE M P PL E 841
Cdd:pfam00183 467 GFSLEDP ASF A S RIYRM L KLGLGIDED EIVEEE deie EEEEEE EE E P EE E 516
HtpG
COG0326 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, ...
137-818
0e+00
Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440095 [Multi-domain]
Cd Length: 616
Bit Score: 750.03
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 137 EV ET FA FQAE IA QL MS L I I NTF YSNKEIFLRELISN S SDA L DK I R YES LTDP SKLDSGKE L H I NLIPN K QDR TLTI V D T G 216
Cdd:COG0326 2 AK ET GE FQAE VK QL LD L M I HSL YSNKEIFLRELISN A SDA I DK L R FLA LTDP ELKEEDGD L K I RIEVD K EAK TLTI S D N G 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 217 IGMT KADL I N NLGTIAKSGT KA F M E A L Q -- AGA D ISM IGQFGVGFYSA YL VA E KV T V I T KH -- N D D E QYA WES SAG G SF T 292
Cdd:COG0326 82 IGMT REEV I E NLGTIAKSGT RE F L E K L K gd QKK D SDL IGQFGVGFYSA FM VA D KV E V V T RS ag E D A E AVR WES DGD G EY T 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 293 VRTDTGEP mg RGT KVI LHLKED QT E Y LEE R R IK EI V KK H S Q FI GY PI TLFV E K E RDK E V sddeaeekedkeeekekeeke 372
Cdd:COG0326 162 IEEAEKAE -- RGT EIT LHLKED AE E F LEE W R LR EI I KK Y S D FI PV PI KMEG E E E ETE E D --------------------- 218
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 373 sedkpeiedvgsdeeeekkdgdkkkkkkikekyidq E EL N KTKPI WTR NPDD IT N EEY G EFYK S L TN D W ED H L AVK H FS V 452
Cdd:COG0326 219 ------------------------------------ E TI N SATAL WTR SKSE IT D EEY K EFYK H L FH D F ED P L FWI H LN V 262
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 453 EG QL E FRA LL FV P RR APFDL F e N R KK K NN IKLYV R RVFIMD NC E E L I PEYL N F I RGVVDS E DLPLN I SRE M LQ QSKI LK V 532
Cdd:COG0326 263 EG PF E YTG LL YI P KK APFDL Y - D R DR K GG IKLYV K RVFIMD DA E D L L PEYL R F V RGVVDS P DLPLN V SRE I LQ EDRQ LK K 341
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 533 IRK NLV KK C L ELFTE LA E - D K E N Y K KF YEQ F SKNI K L G IH ED SQ NR K K LSE LLR YYTSA s GDEM V S L KD Y CT RMKE N QK H 611
Cdd:COG0326 342 IRK AIT KK V L DELEK LA K n D R E K Y E KF WKE F GLVL K E G AL ED FK NR E K IAD LLR FESTK - EGGY V T L AE Y VE RMKE G QK K 420
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 612 IYYITGE TKDQVAN S AFV E RLRKH G L EV IYMIE PIDE YCVQQ L K EF E GK TLV SV TK e G LELPEDE EEKK KQ EE KKTK F EN 691
Cdd:COG0326 421 IYYITGE SREAAEQ S PHL E IFKAK G I EV LLLTD PIDE FLISH L E EF D GK KFK SV DS - G DLDLDKL EEKK ES EE EEEE F KP 499
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 692 L CKIM K DI L EK KV EK V V VS N RL VT SP C C I V TSTYGWTAN ME RIM KA qalrdnst MG -- YMA AK KH LEINP D H SIIET L R q 769
Cdd:COG0326 500 L LERF K EA L GD KV KD V R VS A RL TD SP A C L V ADEGDMSRR ME KML KA -------- MG qd MPE AK PI LEINP N H PLVKK L A - 570
650 660 670 680
....*....|....*....|....*....|....*....|....*....
gi 767980445 770 kae A DKNDKSV KDL VI LLY ET ALL SS G FS LEDP QTHAN R IYRMIKLG LG 818
Cdd:COG0326 571 --- A EEDEELF KDL AE LLY DQ ALL AE G GL LEDP AAFVK R LNKLLEKA LG 616
HATPase_Hsp90-like
cd16927 Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including ...
149-335
2.90e-114
Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including Escherichia coli HtpG, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of 90 kilodalton heat-shock protein (Hsp90) eukaryotic homologs including cytosolic Hsp90, mitochondrial TRAP1 (tumor necrosis factor receptor-associated protein 1), GRP94 (94 kDa glucose-regulated protein) of the endoplasmic reticulum (ER), and chloroplast Hsp90C. It also includes the bacterial homologs of Hsp90, known as HtpG (High temperature protein G). Hsp90 family of chaperones assist other proteins to fold correctly, stabilizes them against heat stress, and aids in protein degradation.
Pssm-ID: 340404 [Multi-domain]
Cd Length: 189
Bit Score: 345.66
E-value: 2.90e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 149 QL MS LII NTF YSNKEIFLRELISN S SDALDK I RY E SLTDPS K LD SGK EL H I NLI P N K QD RTLTI V DTGIGMTK AD LINNL 228
Cdd:cd16927 2 QL LD LII HSL YSNKEIFLRELISN A SDALDK L RY L SLTDPS L LD DDP EL E I RIS P D K EN RTLTI S DTGIGMTK EE LINNL 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 229 GTIA K SGTKAF M EALQ A GA - D ISM IGQFGVGFYSA YL VA E KVTV I TK HN - DDE Q Y A WES SA GGS F T VRTDT GE P m GRGTK 306
Cdd:cd16927 82 GTIA R SGTKAF L EALQ E GA k D SDL IGQFGVGFYSA FM VA D KVTV T TK SA g DDE G Y R WES DG GGS Y T IEEAE GE L - GRGTK 160
170 180
....*....|....*....|....*....
gi 767980445 307 VI LHLKED QT E Y LEE R RIKE I VKK H S Q FI 335
Cdd:cd16927 161 IT LHLKED AK E F LEE A RIKE L VKK Y S D FI 189
HATPase_c
smart00387 Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
161-312
7.61e-12
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain]
Cd Length: 111
Bit Score: 62.67
E-value: 7.61e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 161 NKEIF LR ELI SN SS D ALD K IRY E sltdpsklds G KELHIN L IPNKQDRTL T IV D T G I G MTKA DL innlgtiaksg T K A F M 240
Cdd:smart00387 1 GDPDR LR QVL SN LL D NAI K YTP E ---------- G GRITVT L ERDGDHVEI T VE D N G P G IPPE DL ----------- E K I F E 59
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767980445 241 EALQAGADISM IG QF G V G FYSAYLVA E KV tvitkhnddeqyawessa GG SFT V RTDT gepm G R GT KVILH L K 312
Cdd:smart00387 60 PFFRTDKRSRK IG GT G L G LSIVKKLV E LH ------------------ GG EIS V ESEP ---- G G GT TFTIT L P 109
Name
Accession
Description
Interval
E-value
PTZ00272
PTZ00272 heat shock protein 83 kDa (Hsp83); Provisional
139-853
0e+00
heat shock protein 83 kDa (Hsp83); Provisional
Pssm-ID: 240341
Cd Length: 701
Bit Score: 959.52
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 139 ETFAFQAEI A QLMSLIINTFYSNKEIFLRELISN S SDA L DKIRY E SLTDPS K L DSGKE L H I NLI P N K QDR TLT IV D T GIG 218
Cdd:PTZ00272 3 ETFAFQAEI N QLMSLIINTFYSNKEIFLRELISN A SDA C DKIRY Q SLTDPS V L GESPR L C I RVV P D K ENK TLT VE D N GIG 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 219 MTKADL I NNLGTIA K SGTKAFMEAL Q AG A D I SMIGQFGVGFYSAYLVA EK VTV IT K H N D DE Q Y A WESSAGG S FT VRTDTG 298
Cdd:PTZ00272 83 MTKADL V NNLGTIA R SGTKAFMEAL E AG G D M SMIGQFGVGFYSAYLVA DR VTV TS K N N S DE S Y V WESSAGG T FT ITSTPE 162
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 299 EP M G RGT KVI LHLKEDQ T EYLE E RR I KE IV KKHS Q FIGY P I T L F VEK ERD KEV S D DEA E EKEDKE E EK E KEE kesedkpe 378
Cdd:PTZ00272 163 SD M K RGT RIT LHLKEDQ M EYLE P RR L KE LI KKHS E FIGY D I E L M VEK TTE KEV T D EDE E DTKKAD E DG E EPK -------- 234
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 379 I E D V gs D E EE E K K DGDK KK K K KIKEK Y ID Q eel NK T KP I WTR N P D D I T N EEY GE FYK SLT NDWED HL A V KHFSVEGQLEF 458
Cdd:PTZ00272 235 V E E V -- K E GD E G K KKKT KK V K EVTKE Y EV Q --- NK H KP L WTR D P K D V T K EEY AA FYK AIS NDWED PA A T KHFSVEGQLEF 309
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 459 R ALL FVP R RAPFD L FE NR KK K NNIKLYVRRVFIMDNCE E L I P EY L N F IR GVVDSEDLPLNISRE M LQQ S KILKVIRKN L V 538
Cdd:PTZ00272 310 R SIM FVP K RAPFD M FE PN KK R NNIKLYVRRVFIMDNCE D L C P DW L G F VK GVVDSEDLPLNISRE N LQQ N KILKVIRKN I V 389
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 539 KKCLE L F T E L AE D KE N YK K FYEQF S KNIKLGIHED SQ NRKKL S ELLR Y Y TSA SG D EM VS LKDY C TRMK EN QK H IYYITG E 618
Cdd:PTZ00272 390 KKCLE M F D E V AE N KE D YK Q FYEQF G KNIKLGIHED TA NRKKL M ELLR F Y STE SG E EM TT LKDY V TRMK AG QK S IYYITG D 469
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 619 T K DQVAN S A F V E RL R KH GLEV IY M I EPIDEY CV QQ L K E FE G K TLVSV TKEG LELP E D EEEK KKQ EE K K TKF E N LCK I MK D 698
Cdd:PTZ00272 470 S K KKLET S P F I E QA R RR GLEV LF M T EPIDEY VM QQ V K D FE D K KFACL TKEG VHFE E S EEEK QQR EE E K AAC E K LCK T MK E 549
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 699 I L EK KVEKV V VS N RL V TSPC CI VTS TY GW T A N ME R IM KA QALRD N S TMG YM AA KK HL E I NP D H S II ET LR QKAE AD K NDK 778
Cdd:PTZ00272 550 V L GD KVEKV I VS E RL S TSPC IL VTS EF GW S A H ME Q IM RN QALRD S S MAQ YM MS KK TM E L NP R H P II KE LR RRVG AD E NDK 629
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767980445 779 S VKDLV I LL YE T A LL S SGF S LEDP QTH A N RI Y RMIKLGL GI DE DD pta DDTSA A VTE E MP P L E GDDD TS R ME E VD 853
Cdd:PTZ00272 630 A VKDLV F LL FD T S LL T SGF Q LEDP TGY A E RI N RMIKLGL SL DE EE --- EEAAE A PVA E TA P A E VTAG TS S ME Q VD 701
HSP90
pfam00183 Hsp90 protein;
317-841
0e+00
Hsp90 protein;
Pssm-ID: 459703
Cd Length: 516
Bit Score: 838.75
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 317 EYLEE RR IKE I VKK H S Q FI GY PI T L F VEKE RDK EV S D D E A EE K E DK EEE KEKEE K esedkpe I E DVG sdeeeek KDGD KK 396
Cdd:pfam00183 1 EYLEE KK IKE L VKK Y S E FI NF PI Y L W VEKE EEV EV P D E E E EE E E EE EEE EDDDP K ------- V E EED ------- EEEE KK 66
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 397 K K KK I KE KYIDQ E E LNKTKPIWTRNP DDI T N EEY G EFYKSL TN DWED H LAVKHFSVEG QL EF RA LLF V P R RAPFDLFEN R 476
Cdd:pfam00183 67 K T KK V KE TVWEW E L LNKTKPIWTRNP KEV T E EEY A EFYKSL SK DWED P LAVKHFSVEG EV EF KS LLF I P K RAPFDLFEN K 146
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 477 KKKNNIKLYVRRVFI M D NC E E LIPEYLNF IR GVVDS E DLPLN I SRE M LQQ S KILKVI R K N LV K K C L EL F T E L AE D KE N YK 556
Cdd:pfam00183 147 KKKNNIKLYVRRVFI T D DF E D LIPEYLNF VK GVVDS D DLPLN V SRE T LQQ N KILKVI K K K LV R K A L DM F K E I AE E KE D YK 226
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 557 KF YEQ F S KN I KLGI H EDS Q NR K KL SE LLR Y Y T S A SGDE MV SL K DY CT RMKE N QKHIYYITGE T K DQ V A NS A F V ERL R K H G 636
Cdd:pfam00183 227 KF WKE F G KN L KLGI I EDS S NR N KL AK LLR F Y S S K SGDE LT SL D DY VS RMKE G QKHIYYITGE S K EE V E NS P F L ERL K K K G 306
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 637 L EV I Y MIE PIDEY C VQQLKEF E GK T LV S V T KEGLEL P EDEEEKKK Q EE K K TK FE N L C K IM KD I L EK KVEKVVVSNRLV T S 716
Cdd:pfam00183 307 Y EV L Y LTD PIDEY A VQQLKEF D GK K LV N V A KEGLEL E EDEEEKKK D EE L K KE FE P L T K WL KD V L GD KVEKVVVSNRLV D S 386
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 717 PC CI VTS T YGW T ANMERIMKAQALR - D N S TMG YM AA KK H LEINP D H S II ET L RQKA EADK N DK SV KDL VI LLYETALL S S 795
Cdd:pfam00183 387 PC VL VTS Q YGW S ANMERIMKAQALR k D S S MSS YM SS KK T LEINP R H P II KE L LKRV EADK D DK TA KDL AL LLYETALL R S 466
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|
gi 767980445 796 GFSLEDP QTH A N RIYRM I KLGLGIDED DPTADD ---- TSAAVT EE M P PL E 841
Cdd:pfam00183 467 GFSLEDP ASF A S RIYRM L KLGLGIDED EIVEEE deie EEEEEE EE E P EE E 516
PRK05218
PRK05218 heat shock protein 90; Provisional
137-818
0e+00
heat shock protein 90; Provisional
Pssm-ID: 235366 [Multi-domain]
Cd Length: 613
Bit Score: 772.75
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 137 EV ET FA FQAE IA QL MS L I I NTF YSNKEIFLRELISN S SDA L DK I R Y E S LTDP SKLDSGKE L H I NLIPN K QD RTLTI V D T G 216
Cdd:PRK05218 2 AM ET GE FQAE VK QL LH L M I HSL YSNKEIFLRELISN A SDA I DK L R F E A LTDP ALYEGDGD L K I RISFD K EA RTLTI S D N G 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 217 IGMT KADL I N NLGTIAKSGTK A F M E A L Q -- AGA D ISM IGQFGVGFYSA YL VA E KVTVIT KH -- NDD E QYA WES SAG G SF T 292
Cdd:PRK05218 82 IGMT REEV I E NLGTIAKSGTK E F L E K L K gd QKK D SQL IGQFGVGFYSA FM VA D KVTVIT RS ag PAA E AVR WES DGE G EY T 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 293 VRTDTG E P mg RGT KVI LHLKED QT E Y L E E R RI KE I V KK H S Q FI GY PI T L FV E K E rdkevsddeaeekedkeeekekeeke 372
Cdd:PRK05218 162 IEEIEK E E -- RGT EIT LHLKED ED E F L D E W RI RS I I KK Y S D FI PV PI K L EK E E E -------------------------- 213
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 373 sedkpeiedvgsdeeeekkdgdkkkkkkikekyidq E EL N KTKPI WTR NPDD IT N EEY G EFYK S L TN D WE D H L AVK H FS V 452
Cdd:PRK05218 214 ------------------------------------ E TI N SASAL WTR SKSE IT D EEY K EFYK H L AH D FD D P L FWI H NN V 257
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 453 EG QL E FRA LL FV P RR APFDLF e NR KK K NNI KLYV R RVFIMD NC EEL I PEYL N F IR GV V DSEDLPLN I SRE M LQ QSKIL K V 532
Cdd:PRK05218 258 EG PF E YTG LL YI P KK APFDLF - NR DR K GGL KLYV K RVFIMD DA EEL L PEYL R F VK GV I DSEDLPLN V SRE I LQ EDRVV K K 336
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 533 IRK NLV KK C L ELFTE LA E - D K E N Y K KF YEQ F SKNI K L G IH ED SQ NR K KL SE LLR YYTSAS G d EM VSL KD Y CT RMKE N QK H 611
Cdd:PRK05218 337 IRK AIT KK V L DELEK LA K n D R E K Y E KF WKE F GPVL K E G LY ED FA NR E KL AK LLR FASTHE G - KY VSL AE Y VE RMKE G QK K 415
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 612 IYYITG ETKDQVA NS AFV E RLR K H G L EV IYMIE PIDE YCVQQ L K EF E GK TLV SV TKEG L E - LP EDEEEK KKQ EE KKTK F E 690
Cdd:PRK05218 416 IYYITG DSREAAK NS PHL E LFK K K G I EV LLLTD PIDE FWISY L E EF D GK PFK SV ARGD L D l GK EDEEEK EEK EE AEEE F K 495
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 691 N L CKIM K DI L EK KV EK V VV S N RL VT SP C C I V TSTYGWTAN ME RIM KA QA lrdnst MGYMAA K KH LEINP D H SIIET L RQ k 770
Cdd:PRK05218 496 P L LERL K EA L GD KV KD V RL S H RL TD SP A C L V ADEGDMSTQ ME KLL KA AG ------ QEVPES K PI LEINP N H PLVKK L AD - 568
650 660 670 680
....*....|....*....|....*....|....*....|....*...
gi 767980445 771 aea DKNDKSV KDL VI LLY ET ALL SS G F SLEDP QTHAN R IYRMIKLG L G 818
Cdd:PRK05218 569 --- EADEAKF KDL AE LLY DQ ALL AE G G SLEDP AAFVK R LNELLLKL L A 613
HtpG
COG0326 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, ...
137-818
0e+00
Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440095 [Multi-domain]
Cd Length: 616
Bit Score: 750.03
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 137 EV ET FA FQAE IA QL MS L I I NTF YSNKEIFLRELISN S SDA L DK I R YES LTDP SKLDSGKE L H I NLIPN K QDR TLTI V D T G 216
Cdd:COG0326 2 AK ET GE FQAE VK QL LD L M I HSL YSNKEIFLRELISN A SDA I DK L R FLA LTDP ELKEEDGD L K I RIEVD K EAK TLTI S D N G 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 217 IGMT KADL I N NLGTIAKSGT KA F M E A L Q -- AGA D ISM IGQFGVGFYSA YL VA E KV T V I T KH -- N D D E QYA WES SAG G SF T 292
Cdd:COG0326 82 IGMT REEV I E NLGTIAKSGT RE F L E K L K gd QKK D SDL IGQFGVGFYSA FM VA D KV E V V T RS ag E D A E AVR WES DGD G EY T 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 293 VRTDTGEP mg RGT KVI LHLKED QT E Y LEE R R IK EI V KK H S Q FI GY PI TLFV E K E RDK E V sddeaeekedkeeekekeeke 372
Cdd:COG0326 162 IEEAEKAE -- RGT EIT LHLKED AE E F LEE W R LR EI I KK Y S D FI PV PI KMEG E E E ETE E D --------------------- 218
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 373 sedkpeiedvgsdeeeekkdgdkkkkkkikekyidq E EL N KTKPI WTR NPDD IT N EEY G EFYK S L TN D W ED H L AVK H FS V 452
Cdd:COG0326 219 ------------------------------------ E TI N SATAL WTR SKSE IT D EEY K EFYK H L FH D F ED P L FWI H LN V 262
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 453 EG QL E FRA LL FV P RR APFDL F e N R KK K NN IKLYV R RVFIMD NC E E L I PEYL N F I RGVVDS E DLPLN I SRE M LQ QSKI LK V 532
Cdd:COG0326 263 EG PF E YTG LL YI P KK APFDL Y - D R DR K GG IKLYV K RVFIMD DA E D L L PEYL R F V RGVVDS P DLPLN V SRE I LQ EDRQ LK K 341
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 533 IRK NLV KK C L ELFTE LA E - D K E N Y K KF YEQ F SKNI K L G IH ED SQ NR K K LSE LLR YYTSA s GDEM V S L KD Y CT RMKE N QK H 611
Cdd:COG0326 342 IRK AIT KK V L DELEK LA K n D R E K Y E KF WKE F GLVL K E G AL ED FK NR E K IAD LLR FESTK - EGGY V T L AE Y VE RMKE G QK K 420
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 612 IYYITGE TKDQVAN S AFV E RLRKH G L EV IYMIE PIDE YCVQQ L K EF E GK TLV SV TK e G LELPEDE EEKK KQ EE KKTK F EN 691
Cdd:COG0326 421 IYYITGE SREAAEQ S PHL E IFKAK G I EV LLLTD PIDE FLISH L E EF D GK KFK SV DS - G DLDLDKL EEKK ES EE EEEE F KP 499
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 692 L CKIM K DI L EK KV EK V V VS N RL VT SP C C I V TSTYGWTAN ME RIM KA qalrdnst MG -- YMA AK KH LEINP D H SIIET L R q 769
Cdd:COG0326 500 L LERF K EA L GD KV KD V R VS A RL TD SP A C L V ADEGDMSRR ME KML KA -------- MG qd MPE AK PI LEINP N H PLVKK L A - 570
650 660 670 680
....*....|....*....|....*....|....*....|....*....
gi 767980445 770 kae A DKNDKSV KDL VI LLY ET ALL SS G FS LEDP QTHAN R IYRMIKLG LG 818
Cdd:COG0326 571 --- A EEDEELF KDL AE LLY DQ ALL AE G GL LEDP AAFVK R LNKLLEKA LG 616
PTZ00130
PTZ00130 heat shock protein 90; Provisional
124-851
8.00e-167
heat shock protein 90; Provisional
Pssm-ID: 185466 [Multi-domain]
Cd Length: 814
Bit Score: 504.96
E-value: 8.00e-167
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 124 E E TQTQDQ P MEE ee V E TFAF Q A E IAQ LM SL I I N TF Y SN KE I FLRELISN SS DAL D KIR YE SL T D P S K L DSG K E L H I NLIP 203
Cdd:PTZ00130 53 P E IEDGEK P TSG -- I E QHQY Q T E VTR LM DI I V N SL Y TQ KE V FLRELISN AA DAL E KIR FL SL S D E S V L GEE K K L E I RISA 130
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 204 NK QDRT L T I V DTGIGMTK A DLINNLGTIAKSGT KA F M EA L - QA G A D I S M IGQFGVGFYSA Y LVA E KV T V I TK H N D DEQY A 282
Cdd:PTZ00130 131 NK EKNI L S I T DTGIGMTK E DLINNLGTIAKSGT SN F L EA I s KS G G D M S L IGQFGVGFYSA F LVA D KV I V Y TK N N N DEQY I 210
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 283 WES S A GGS FT VRT D T - G EPMG RGT KVI LHLKED Q T EYLEERRIKEIVK K H SQFI G YPI T L FV E KERDK EV sddeaeeked 361
Cdd:PTZ00130 211 WES T A DAK FT IYK D P r G STLK RGT RIS LHLKED A T NLMNDKKLVDLIS K Y SQFI Q YPI Y L LH E NVYTE EV ---------- 280
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 362 keeekekee KESED K PEIE D VGS D EEEEKKDG D KK KK KKIK EK YIDQEE L - N KT KPIW T R N P DDI T N E E Y GE F YKS L TND 440
Cdd:PTZ00130 281 --------- LADIA K EMEN D PNY D SVKVEETD D PN KK TRTV EK KVKKWK L m N EQ KPIW L R P P KEL T D E D Y KK F FSV L SGF 351
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 441 WEDH L AVK HF SV EG QL EF RA L LFV P R RAP FDLFENRK K K N N IKLYVRRV FIM D NCE E LI P E Y LN F IR GVVDS E DLPLN I S 520
Cdd:PTZ00130 352 NDEP L YHI HF FA EG EI EF KC L IYI P S RAP SINDHLFT K Q N S IKLYVRRV LVA D EFV E FL P R Y MS F VK GVVDS D DLPLN V S 431
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 521 RE M LQQ S KILK VIR K NL V K K C L E ---- L FT E LAED KE N -------------------------- YK KF Y EQFS K NI K L G I 570
Cdd:PTZ00130 432 RE Q LQQ N KILK AVS K RI V R K I L D tfrt L YK E GKKN KE T lraelaketdeekkkeiqkkinepst YK LI Y KEYR K YL K T G C 511
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 571 H ED SQ NR K K LSE LL RYY T SAS g DEMV SL KD Y CTR MK EN QK H IYY IT G ETKDQVANSAFVERLR K HGLE V IYMI E PI DE Y C 650
Cdd:PTZ00130 512 Y ED DI NR N K IVK LL LFK T MLH - PKSI SL DT Y IEN MK PD QK F IYY AS G DSYEYLSKIPQLQIFK K KNID V VFLT E SV DE S C 590
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 651 VQ QLK E FE GK TLV S VT K EGLELPED E E EKKK Q E EK K TKFEN L CKIMK D I L EKKVE KV VV S N RLV TS PC CI V TSTY G WTAN 730
Cdd:PTZ00130 591 VQ RVQ E YD GK KFK S IQ K GEITFELT E D EKKK E E KV K KMYKA L IDVIS D T L RNQIF KV EI S R RLV DA PC AV V STEW G LSGQ 670
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 731 ME RI MK AQ a LRDNSTMGY M AAK K H LEINPDH S I IET L RQKAEADKN D KSVKDLVILL Y ET A L L S SGF S LED PQTH A NRI Y 810
Cdd:PTZ00130 671 ME KL MK IN - VNNSDQIKA M SGQ K I LEINPDH P I MID L LKRSVSNPK D SQLTESIKII Y QS A K L A SGF D LED TADL A QIV Y 749
730 740 750 760
....*....|....*....|....*....|....*....|..
gi 767980445 811 RM I KLG LG I D EDDPTA D - D TSAAV T EEMPP l E GDD D TSRME E 851
Cdd:PTZ00130 750 DH I NQK LG V D NNLKID D l D PAIFE T KKIEQ - E DSP D GQKFH E 790
HATPase_Hsp90-like
cd16927 Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including ...
149-335
2.90e-114
Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including Escherichia coli HtpG, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of 90 kilodalton heat-shock protein (Hsp90) eukaryotic homologs including cytosolic Hsp90, mitochondrial TRAP1 (tumor necrosis factor receptor-associated protein 1), GRP94 (94 kDa glucose-regulated protein) of the endoplasmic reticulum (ER), and chloroplast Hsp90C. It also includes the bacterial homologs of Hsp90, known as HtpG (High temperature protein G). Hsp90 family of chaperones assist other proteins to fold correctly, stabilizes them against heat stress, and aids in protein degradation.
Pssm-ID: 340404 [Multi-domain]
Cd Length: 189
Bit Score: 345.66
E-value: 2.90e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 149 QL MS LII NTF YSNKEIFLRELISN S SDALDK I RY E SLTDPS K LD SGK EL H I NLI P N K QD RTLTI V DTGIGMTK AD LINNL 228
Cdd:cd16927 2 QL LD LII HSL YSNKEIFLRELISN A SDALDK L RY L SLTDPS L LD DDP EL E I RIS P D K EN RTLTI S DTGIGMTK EE LINNL 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 229 GTIA K SGTKAF M EALQ A GA - D ISM IGQFGVGFYSA YL VA E KVTV I TK HN - DDE Q Y A WES SA GGS F T VRTDT GE P m GRGTK 306
Cdd:cd16927 82 GTIA R SGTKAF L EALQ E GA k D SDL IGQFGVGFYSA FM VA D KVTV T TK SA g DDE G Y R WES DG GGS Y T IEEAE GE L - GRGTK 160
170 180
....*....|....*....|....*....
gi 767980445 307 VI LHLKED QT E Y LEE R RIKE I VKK H S Q FI 335
Cdd:cd16927 161 IT LHLKED AK E F LEE A RIKE L VKK Y S D FI 189
PRK14083
PRK14083 HSP90 family protein; Provisional
142-537
4.81e-32
HSP90 family protein; Provisional
Pssm-ID: 237603 [Multi-domain]
Cd Length: 601
Bit Score: 132.76
E-value: 4.81e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 142 A FQ AEIAQLMS L IINTF YS NKEIFL REL IS N SS DA ldk I RYESLT DP S kl DS G K e LH I N L i PNKQDR TL TIV D T GIG M T K 221
Cdd:PRK14083 4 R FQ VDLRGVID L LSRHL YS SPRVYV REL LQ N AV DA --- I TARRAL DP T -- AP G R - IR I E L - TDAGGG TL IVE D N GIG L T E 76
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 222 ADLINN L G TI AK S GTKA fm E A L QAGAD i SMI GQFG V G FY S AY LVA EKVT V ITKHND D EQ - YA W ESS A G G SFT VR TDTG E P 300
Cdd:PRK14083 77 EEVHEF L A TI GR S SKRD -- E N L GFARN - DFL GQFG I G LL S CF LVA DEIV V VSRSAK D GP a VE W RGK A D G TYS VR KLET E R 153
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 301 MGR GT K V I L HLKE D QT E Y LE ERRIK E IV KK HSQFIGY PI TLFV EK ER dkevsddeaeekedkeeekekeekesedkpeie 380
Cdd:PRK14083 154 AEP GT T V Y L RPRP D AE E W LE RETVE E LA KK YGSLLPV PI RVEG EK GG --------------------------------- 200
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 381 dvgsdeeeekkdgdkkkkkkikekyidqee L N K T K P I WTR NPD D ITNE ----- E YGE fy KS L TNDWE D H -- L A V KHFSV E 453
Cdd:PRK14083 201 ------------------------------ V N E T P P P WTR DYP D PETR reall A YGE -- EL L GFTPL D V ip L D V PSGGL E 248
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 454 G qlefra LLF V - P RRAPF dlfe NRKK K N ni KL Y VR R VFIMDNC E E L I P EYLN F I R G VV DSED L PLNI SRE M L QQSKI L KV 532
Cdd:PRK14083 249 G ------ VAY V l P YAVSP ---- AARR K H -- RV Y LK R MLLSEEA E N L L P DWAF F V R C VV NTDE L RPTA SRE A L YEDDA L AA 316
....*
gi 767980445 533 I R KN L 537
Cdd:PRK14083 317 V R EE L 321
HATPase_c
smart00387 Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
161-312
7.61e-12
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain]
Cd Length: 111
Bit Score: 62.67
E-value: 7.61e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 161 NKEIF LR ELI SN SS D ALD K IRY E sltdpsklds G KELHIN L IPNKQDRTL T IV D T G I G MTKA DL innlgtiaksg T K A F M 240
Cdd:smart00387 1 GDPDR LR QVL SN LL D NAI K YTP E ---------- G GRITVT L ERDGDHVEI T VE D N G P G IPPE DL ----------- E K I F E 59
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767980445 241 EALQAGADISM IG QF G V G FYSAYLVA E KV tvitkhnddeqyawessa GG SFT V RTDT gepm G R GT KVILH L K 312
Cdd:smart00387 60 PFFRTDKRSRK IG GT G L G LSIVKKLV E LH ------------------ GG EIS V ESEP ---- G G GT TFTIT L P 109
HATPase_c_3
pfam13589 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ...
163-280
1.77e-09
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 433332 [Multi-domain]
Cd Length: 135
Bit Score: 56.57
E-value: 1.77e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 163 E IF L R ELI S NS S DA ldkiryesltdpskld SGKELH I NLIP N KQDR T - LT I V D T G I GM TKAD LIN N L G t I A K S GTK afme 241
Cdd:pfam13589 2 E GA L A ELI D NS I DA ---------------- DATNIK I EVNK N RGGG T e IV I E D D G H GM SPEE LIN A L R - L A T S AKE ---- 60
90 100 110 120
....*....|....*....|....*....|....*....|
gi 767980445 242 alq A GADISMI G QF G V G FYS A Y L V - AE K V TV IT K HNDDEQ 280
Cdd:pfam13589 61 --- A KRGSTDL G RY G I G LKL A S L S l GA K L TV TS K KEGKSS 97
HATPase_c
pfam02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
161-315
9.78e-06
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain]
Cd Length: 109
Bit Score: 45.05
E-value: 9.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767980445 161 NK E IF LR ELI SN SS D ALD K IRYE sltdpsklds GK E LHIN L IP n KQDR TLT IV D T GIG MTKA DL innlgti AKSGTK a F M 240
Cdd:pfam02518 1 GD E LR LR QVL SN LL D NAL K HAAK ---------- AG E ITVT L SE - GGEL TLT VE D N GIG IPPE DL ------- PRIFEP - F S 61
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767980445 241 E alqag AD ISMI G QF G V G FYSAYLVA E KV tvitkhnddeqyawessa GG SF TV RTDT gepm G R GT K V I L H L KED Q 315
Cdd:pfam02518 62 T ----- AD KRGG G GT G L G LSIVRKLV E LL ------------------ GG TI TV ESEP ---- G G GT T V T L T L PLA Q 109
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
