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Conserved domains on  [gi|767974033|ref|XP_011536565|]
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acetyl-CoA carboxylase 2 isoform X1 [Homo sapiens]

Protein Classification

acetyl-CoA carboxylase( domain architecture ID 18109860)

acetyl-CoA carboxylase (ACC) carries out three functions: biotin carboxyl carrier protein, biotin carboxylase, and carboxyltransferase; it is involved in the synthesis of very-long-chain fatty acid synthesis which is required to maintain a functional nuclear envelope

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ACC_central pfam08326
Acetyl-CoA carboxylase, central region; The region featured in this family is found in various ...
962-1625 0e+00

Acetyl-CoA carboxylase, central region; The region featured in this family is found in various eukaryotic acetyl-CoA carboxylases, N-terminal to the catalytic domain (pfam01039). This enzyme (EC:6.4.1.2) is involved in the synthesis of long-chain fatty acids, as it catalyzes the rate-limiting step in this process.


:

Pssm-ID: 462429  Cd Length: 718  Bit Score: 898.08  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033   962 ELDDPSKVHPAEPFTGELPAQQTLPILGEKLHQVFHSVLENLTNVMSGFCL-----------------PE-PVF------ 1017
Cdd:pfam08326    1 ALDDPSRVKHAQPFEGQLPELGPPTVVGNKPHQRFAALLNILENILAGYDNqvimnetlkdlievlrdPElPYLewqeql 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  1018 ------------------------------SIKIATILDCHAATLQRKADREVFFINTQSIVQLVQRYRSGIRGYMKTVV 1067
Cdd:pfam08326   81 salsgripakleaslrqlverahsrsaefpAKQLRKILDKFLAELVLKADRDLFEATLAPLVDLVERYRNGLKGHEYSVF 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  1068 LDLLRRYLRVEHHFQQA--HYDKCVINLREQFKPDMSQVLDCIFSHAQVAKKNQLVIMLIDELCGP---DPSLSDELISI 1142
Cdd:pfam08326  161 ASLLEEYYDVEKLFSGGnvREEDVILKLRDENKDDLDKVVDIVLSHSRVSSKNKLILALLDHYRPNcpnVSNVAKELRPV 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  1143 LNELTQLSKSEHCKVALRARQILIASHLPSYELRHNQVESIFLSAIDMYGH--------QFCPENLKKLILSETTIFDVL 1214
Cdd:pfam08326  241 LKKLAELESRETAKVALKAREVLIQCALPSLEERKNQMEHILKSSVVESGYgesgwkhrEPSLEVLKELIDSKYTVFDVL 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  1215 PTFFYHANKVVCMASLEVYVRRGYIAYELNSLQHRQLPDGTCVVEFQFMLPSSHPNRMTVPISITNPDLLRH------ST 1288
Cdd:pfam08326  321 PPFFYHSDPWVSLAALEVYVRRAYRAYSLKSIQYHEGEDSPPIVSWQFQLPSSHSSEFGSPLSPSSDSSPPFkriasvSD 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  1289 ELFMDSGFSPLCQRMGAMVAFRRFEDFTRNFDEVISCFANVPKDTPLfseartslyseddcKSLREEPIHILNVSIQCAD 1368
Cdd:pfam08326  401 LSYLVNKSEDEPLRTGAMVAFKSLDDLEEALPRALEEFPSEPEESGE--------------SNSSDEPINVLNVAIRDAE 466
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  1369 HLE-DEALVPILRTFVQSKKNILVDYGLRRITFLIAQE-KEFPKFFTFRARDEFAEDRIYRHLEPALAFQLELNRMRNFD 1446
Cdd:pfam08326  467 GSDsDEELLERLEEILKENKEELLAAGVRRITFIIGRKdGQYPKYFTFRGPDNYEEDPIIRHIEPALAFQLELGRLSNFD 546
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  1447 LTAVPCANHKMHLYLGAAKVKEgvevTDHRFFIRAIIRHSDLITKEASFEYLQNEGERLLLEAMDELEVAfNNTSVRTDC 1526
Cdd:pfam08326  547 IKPVPTENRQIHLYEAVGKENP----TDKRFFVRAIIRPGRLRDDIPTAEYLISEAERLLNDILDALEVA-SIGNSNSDL 621
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  1527 NHIFLNFVPTVIMDPFKIEESVRYMVMRYGSRLWKLRVLQAEVKINIRQTTTGSAVPIRLFITNESGYYLDISLYKEVTD 1606
Cdd:pfam08326  622 NHIFLNFVPVFNVDPEDVEEAVGGFLERFGKRLWRLRVTQAEIRIIIRDPETGPPIPLRLVITNVSGYVVKVELYREVKD 701
                          730
                   ....*....|....*....
gi 767974033  1607 SRsGNIMFHSFGnKQGPQH 1625
Cdd:pfam08326  702 DK-GEWVFKSIG-KPGPMH 718
Carboxyl_trans pfam01039
Carboxyl transferase domain; All of the members in this family are biotin dependent ...
1717-2265 0e+00

Carboxyl transferase domain; All of the members in this family are biotin dependent carboxylases. The carboxyl transferase domain carries out the following reaction; transcarboxylation from biotin to an acceptor molecule. There are two recognized types of carboxyl transferase. One of them uses acyl-CoA and the other uses 2-oxoacid as the acceptor molecule of carbon dioxide. All of the members in this family utilize acyl-CoA as the acceptor molecule.


:

Pssm-ID: 426008 [Multi-domain]  Cd Length: 491  Bit Score: 618.50  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  1717 QEYPEGRDVIVIGNDITFRIGSFGPGEDLLYLRASEMARAEgIPKIYVAANSGARIGMAEEIKHMFHVAWVDPEDPHKGF 1796
Cdd:pfam01039    1 PEHPRGKLTARERIDLLLDPGSFGELEDLFFHRATEFGRKR-IPRDGVVTGSGAVIGRAVEVVAQDFTVFGGSLGPAKGE 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  1797 KylyLTPQDYTRISSlnsvhckhieegGESRYMITDIIGKDDGLGVENLRGSGMIAGESSLAYEEIVTISLVTCRAIGIG 1876
Cdd:pfam01039   80 K---ILRAMEIAIKT------------GLPLIGINDSGGARIQEGVENLRGSGKIFGRNSLASGVIPQISLIMGPCAGGG 144
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  1877 AYLVRLGQRVIQVEN-SHIILTGASALNKVLGrEVYTSNNQLGGVQIMHYNGVSHITVPDDFEGVYTILEWLSYMPKDNH 1955
Cdd:pfam01039  145 AYLPALGDFVIMVEGtSPMFLTGPPVIKKVTG-EEVTSEELGGATQHMTISGVSHLTALDDEDALELIRKWLSYLPKPAP 223
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  1956 S---PVPIITPTDPIDRE---IEFLPS--RAPYDPRWMLAGRphptlkgtwqsgfFDHGSFKEIMAPWAQTVVTGRARLG 2027
Cdd:pfam01039  224 NnrePVPIVPTKDPPDRDaplVSIVPDdpKKPYDVREVIAGI-------------VDEGEFFEIKPGYAKTVVTGFARLG 290
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  2028 GIPVGVIAVETRtvevavpadpanldseakiiQQAGqVWFPDSAYKTAQAVKDFNREKLPLMIFANWRGFSGGMKDMYDQ 2107
Cdd:pfam01039  291 GIPVGVVANQPR--------------------VGAG-VLFPDSADKAARFIRDCDAFNLPLVILADVPGFLPGQRQEYGG 349
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  2108 VLKFGAYIVDGLRQYKQPILIYIPPyaELRGGSWVVIDATINPLCIeMYADKESRGGVLEPEGTVEIKFRKKDLIKSMRR 2187
Cdd:pfam01039  350 ILKHGAKLLYALAEATVPKITVIPR--KAYGGAYVVMDSKINGADI-NFAWPTARIAVMGPEGAVEIKFRKEKAAAEMRG 426
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767974033  2188 IDPAYKKlmeqlgepdlsdkdrkdlEGRLKAREDLLLPIYHQVAVQFADFHDTPGRMLEKGVISDILEWKTARtFLYW 2265
Cdd:pfam01039  427 KDLAATR------------------KQKIAEYEEELSPPYVAAARGFADAVIDPGRTRAKLVIALAALWTKPR-FFPW 485
PccA super family cl44129
Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid transport and metabolism];
260-786 5.30e-132

Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid transport and metabolism];


The actual alignment was detected with superfamily member COG4770:

Pssm-ID: 443802 [Multi-domain]  Cd Length: 466  Bit Score: 422.89  E-value: 5.30e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  260 IEKVLIANNGIAAVKCMRSIRrwayEMfrnerAIRFVVMVTPEDlkANAEYIKMADHYVPVPGGPNNNNYANVELIVDIA 339
Cdd:COG4770     2 FKKVLIANRGEIAVRIIRTCR----EL-----GIRTVAVYSDAD--RDALHVRLADEAVCIGPAPAAESYLNIDAIIAAA 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  340 KRIPVQAVWAGWGHASENPKLPELLCKNGVAFLGPPSEAMWALGDKIASTVVAQTLQVPTLPWSgsgltvewteddlqqg 419
Cdd:COG4770    71 KATGADAIHPGYGFLSENADFAEACEDAGIVFIGPSPEAIRAMGDKIAAKKLMKAAGVPVVPGS---------------- 134
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  420 krisvpedvydKGCVKDVDEGLEAAERIGFPLMIKASEGGGGKGIRKAESAEDFPILFRQVQSE---IPGSP-IFLMKLA 495
Cdd:COG4770   135 -----------DGPVQDAEEALAIAEEIGYPVLIKASAGGGGKGMRVVRSEEELEEAFESARREakaAFGDDrVYLEKYI 203
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  496 QHARHLEVQILADQYGNAVSLFGRDCSIQRRHQKIVEEAPATIAPLAIFEFMEQCAIRLAKTVGYVSAGTVEYLYSQDGS 575
Cdd:COG4770   204 ERPRHIEVQVLADKHGNVVHLGERDCSIQRRHQKVIEEAPSPALTEELRERMGEAAVRAAKAVGYVGAGTVEFLVDADGN 283
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  576 FHFLELNPRLQVEHPCTEMIADVNLPAAQLQIAMGVPLH-RLKDIRLlygespwgvtpisfetpsnpplaRGHVIAARIT 654
Cdd:COG4770   284 FYFLEMNTRLQVEHPVTEMVTGIDLVEEQIRIAAGEPLPfTQEDIKL-----------------------RGHAIECRIN 340
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  655 SENPDEGFKPSSGTVQELNFRSSknvwgyFSVAATGGLHE------FADSQFGHCFSWGENREEAISNMVVALKELSIRG 728
Cdd:COG4770   341 AEDPARGFLPSPGTITRLRPPGG------PGVRVDSGVYEgyeippYYDSMIAKLIVWGPDREEAIARMRRALAEFVIEG 414
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 767974033  729 dFRTTVEYLINLLETESFQNNDIDTGWLDYLIAEKVQAEKPDimlgvvcgALNVADAM 786
Cdd:COG4770   415 -VKTNIPFLRALLAHPDFRAGDVDTGFIERELAELLAAAAPE--------ELALAAAM 463
Biotin_lipoyl pfam00364
Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue ...
895-961 6.71e-16

Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue binds biotin in one group and lipoic acid in the other. Note that the HMM does not currently recognize the Glycine cleavage system H proteins.


:

Pssm-ID: 395290 [Multi-domain]  Cd Length: 73  Bit Score: 74.17  E-value: 6.71e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767974033   895 TVLRSPSAGKL-----TQYTVEDGGHVEAGSSYAEMEVMKMIMTLNVQERGRVKYIKRP-GAVLEAGCVVARL 961
Cdd:pfam00364    1 TEIKSPMIGESvregvVEWLVKVGDKVKAGQPLAEVEAMKMEMEIPAPVAGVVKEILVPeGDTVEVGDPLAKI 73
 
Name Accession Description Interval E-value
ACC_central pfam08326
Acetyl-CoA carboxylase, central region; The region featured in this family is found in various ...
962-1625 0e+00

Acetyl-CoA carboxylase, central region; The region featured in this family is found in various eukaryotic acetyl-CoA carboxylases, N-terminal to the catalytic domain (pfam01039). This enzyme (EC:6.4.1.2) is involved in the synthesis of long-chain fatty acids, as it catalyzes the rate-limiting step in this process.


Pssm-ID: 462429  Cd Length: 718  Bit Score: 898.08  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033   962 ELDDPSKVHPAEPFTGELPAQQTLPILGEKLHQVFHSVLENLTNVMSGFCL-----------------PE-PVF------ 1017
Cdd:pfam08326    1 ALDDPSRVKHAQPFEGQLPELGPPTVVGNKPHQRFAALLNILENILAGYDNqvimnetlkdlievlrdPElPYLewqeql 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  1018 ------------------------------SIKIATILDCHAATLQRKADREVFFINTQSIVQLVQRYRSGIRGYMKTVV 1067
Cdd:pfam08326   81 salsgripakleaslrqlverahsrsaefpAKQLRKILDKFLAELVLKADRDLFEATLAPLVDLVERYRNGLKGHEYSVF 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  1068 LDLLRRYLRVEHHFQQA--HYDKCVINLREQFKPDMSQVLDCIFSHAQVAKKNQLVIMLIDELCGP---DPSLSDELISI 1142
Cdd:pfam08326  161 ASLLEEYYDVEKLFSGGnvREEDVILKLRDENKDDLDKVVDIVLSHSRVSSKNKLILALLDHYRPNcpnVSNVAKELRPV 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  1143 LNELTQLSKSEHCKVALRARQILIASHLPSYELRHNQVESIFLSAIDMYGH--------QFCPENLKKLILSETTIFDVL 1214
Cdd:pfam08326  241 LKKLAELESRETAKVALKAREVLIQCALPSLEERKNQMEHILKSSVVESGYgesgwkhrEPSLEVLKELIDSKYTVFDVL 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  1215 PTFFYHANKVVCMASLEVYVRRGYIAYELNSLQHRQLPDGTCVVEFQFMLPSSHPNRMTVPISITNPDLLRH------ST 1288
Cdd:pfam08326  321 PPFFYHSDPWVSLAALEVYVRRAYRAYSLKSIQYHEGEDSPPIVSWQFQLPSSHSSEFGSPLSPSSDSSPPFkriasvSD 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  1289 ELFMDSGFSPLCQRMGAMVAFRRFEDFTRNFDEVISCFANVPKDTPLfseartslyseddcKSLREEPIHILNVSIQCAD 1368
Cdd:pfam08326  401 LSYLVNKSEDEPLRTGAMVAFKSLDDLEEALPRALEEFPSEPEESGE--------------SNSSDEPINVLNVAIRDAE 466
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  1369 HLE-DEALVPILRTFVQSKKNILVDYGLRRITFLIAQE-KEFPKFFTFRARDEFAEDRIYRHLEPALAFQLELNRMRNFD 1446
Cdd:pfam08326  467 GSDsDEELLERLEEILKENKEELLAAGVRRITFIIGRKdGQYPKYFTFRGPDNYEEDPIIRHIEPALAFQLELGRLSNFD 546
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  1447 LTAVPCANHKMHLYLGAAKVKEgvevTDHRFFIRAIIRHSDLITKEASFEYLQNEGERLLLEAMDELEVAfNNTSVRTDC 1526
Cdd:pfam08326  547 IKPVPTENRQIHLYEAVGKENP----TDKRFFVRAIIRPGRLRDDIPTAEYLISEAERLLNDILDALEVA-SIGNSNSDL 621
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  1527 NHIFLNFVPTVIMDPFKIEESVRYMVMRYGSRLWKLRVLQAEVKINIRQTTTGSAVPIRLFITNESGYYLDISLYKEVTD 1606
Cdd:pfam08326  622 NHIFLNFVPVFNVDPEDVEEAVGGFLERFGKRLWRLRVTQAEIRIIIRDPETGPPIPLRLVITNVSGYVVKVELYREVKD 701
                          730
                   ....*....|....*....
gi 767974033  1607 SRsGNIMFHSFGnKQGPQH 1625
Cdd:pfam08326  702 DK-GEWVFKSIG-KPGPMH 718
Carboxyl_trans pfam01039
Carboxyl transferase domain; All of the members in this family are biotin dependent ...
1717-2265 0e+00

Carboxyl transferase domain; All of the members in this family are biotin dependent carboxylases. The carboxyl transferase domain carries out the following reaction; transcarboxylation from biotin to an acceptor molecule. There are two recognized types of carboxyl transferase. One of them uses acyl-CoA and the other uses 2-oxoacid as the acceptor molecule of carbon dioxide. All of the members in this family utilize acyl-CoA as the acceptor molecule.


Pssm-ID: 426008 [Multi-domain]  Cd Length: 491  Bit Score: 618.50  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  1717 QEYPEGRDVIVIGNDITFRIGSFGPGEDLLYLRASEMARAEgIPKIYVAANSGARIGMAEEIKHMFHVAWVDPEDPHKGF 1796
Cdd:pfam01039    1 PEHPRGKLTARERIDLLLDPGSFGELEDLFFHRATEFGRKR-IPRDGVVTGSGAVIGRAVEVVAQDFTVFGGSLGPAKGE 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  1797 KylyLTPQDYTRISSlnsvhckhieegGESRYMITDIIGKDDGLGVENLRGSGMIAGESSLAYEEIVTISLVTCRAIGIG 1876
Cdd:pfam01039   80 K---ILRAMEIAIKT------------GLPLIGINDSGGARIQEGVENLRGSGKIFGRNSLASGVIPQISLIMGPCAGGG 144
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  1877 AYLVRLGQRVIQVEN-SHIILTGASALNKVLGrEVYTSNNQLGGVQIMHYNGVSHITVPDDFEGVYTILEWLSYMPKDNH 1955
Cdd:pfam01039  145 AYLPALGDFVIMVEGtSPMFLTGPPVIKKVTG-EEVTSEELGGATQHMTISGVSHLTALDDEDALELIRKWLSYLPKPAP 223
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  1956 S---PVPIITPTDPIDRE---IEFLPS--RAPYDPRWMLAGRphptlkgtwqsgfFDHGSFKEIMAPWAQTVVTGRARLG 2027
Cdd:pfam01039  224 NnrePVPIVPTKDPPDRDaplVSIVPDdpKKPYDVREVIAGI-------------VDEGEFFEIKPGYAKTVVTGFARLG 290
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  2028 GIPVGVIAVETRtvevavpadpanldseakiiQQAGqVWFPDSAYKTAQAVKDFNREKLPLMIFANWRGFSGGMKDMYDQ 2107
Cdd:pfam01039  291 GIPVGVVANQPR--------------------VGAG-VLFPDSADKAARFIRDCDAFNLPLVILADVPGFLPGQRQEYGG 349
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  2108 VLKFGAYIVDGLRQYKQPILIYIPPyaELRGGSWVVIDATINPLCIeMYADKESRGGVLEPEGTVEIKFRKKDLIKSMRR 2187
Cdd:pfam01039  350 ILKHGAKLLYALAEATVPKITVIPR--KAYGGAYVVMDSKINGADI-NFAWPTARIAVMGPEGAVEIKFRKEKAAAEMRG 426
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767974033  2188 IDPAYKKlmeqlgepdlsdkdrkdlEGRLKAREDLLLPIYHQVAVQFADFHDTPGRMLEKGVISDILEWKTARtFLYW 2265
Cdd:pfam01039  427 KDLAATR------------------KQKIAEYEEELSPPYVAAARGFADAVIDPGRTRAKLVIALAALWTKPR-FFPW 485
PccA COG4770
Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid transport and metabolism];
260-786 5.30e-132

Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid transport and metabolism];


Pssm-ID: 443802 [Multi-domain]  Cd Length: 466  Bit Score: 422.89  E-value: 5.30e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  260 IEKVLIANNGIAAVKCMRSIRrwayEMfrnerAIRFVVMVTPEDlkANAEYIKMADHYVPVPGGPNNNNYANVELIVDIA 339
Cdd:COG4770     2 FKKVLIANRGEIAVRIIRTCR----EL-----GIRTVAVYSDAD--RDALHVRLADEAVCIGPAPAAESYLNIDAIIAAA 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  340 KRIPVQAVWAGWGHASENPKLPELLCKNGVAFLGPPSEAMWALGDKIASTVVAQTLQVPTLPWSgsgltvewteddlqqg 419
Cdd:COG4770    71 KATGADAIHPGYGFLSENADFAEACEDAGIVFIGPSPEAIRAMGDKIAAKKLMKAAGVPVVPGS---------------- 134
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  420 krisvpedvydKGCVKDVDEGLEAAERIGFPLMIKASEGGGGKGIRKAESAEDFPILFRQVQSE---IPGSP-IFLMKLA 495
Cdd:COG4770   135 -----------DGPVQDAEEALAIAEEIGYPVLIKASAGGGGKGMRVVRSEEELEEAFESARREakaAFGDDrVYLEKYI 203
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  496 QHARHLEVQILADQYGNAVSLFGRDCSIQRRHQKIVEEAPATIAPLAIFEFMEQCAIRLAKTVGYVSAGTVEYLYSQDGS 575
Cdd:COG4770   204 ERPRHIEVQVLADKHGNVVHLGERDCSIQRRHQKVIEEAPSPALTEELRERMGEAAVRAAKAVGYVGAGTVEFLVDADGN 283
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  576 FHFLELNPRLQVEHPCTEMIADVNLPAAQLQIAMGVPLH-RLKDIRLlygespwgvtpisfetpsnpplaRGHVIAARIT 654
Cdd:COG4770   284 FYFLEMNTRLQVEHPVTEMVTGIDLVEEQIRIAAGEPLPfTQEDIKL-----------------------RGHAIECRIN 340
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  655 SENPDEGFKPSSGTVQELNFRSSknvwgyFSVAATGGLHE------FADSQFGHCFSWGENREEAISNMVVALKELSIRG 728
Cdd:COG4770   341 AEDPARGFLPSPGTITRLRPPGG------PGVRVDSGVYEgyeippYYDSMIAKLIVWGPDREEAIARMRRALAEFVIEG 414
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 767974033  729 dFRTTVEYLINLLETESFQNNDIDTGWLDYLIAEKVQAEKPDimlgvvcgALNVADAM 786
Cdd:COG4770   415 -VKTNIPFLRALLAHPDFRAGDVDTGFIERELAELLAAAAPE--------ELALAAAM 463
PRK08591 PRK08591
acetyl-CoA carboxylase biotin carboxylase subunit; Validated
260-766 7.04e-112

acetyl-CoA carboxylase biotin carboxylase subunit; Validated


Pssm-ID: 236307 [Multi-domain]  Cd Length: 451  Bit Score: 364.51  E-value: 7.04e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  260 IEKVLIANNGIAAVKCMRSIRrwayemfrnERAIRFVVMVTPEDlkANAEYIKMADHYVPVPGGPNNNNYANVELIVDIA 339
Cdd:PRK08591    2 FDKILIANRGEIALRIIRACK---------ELGIKTVAVHSTAD--RDALHVQLADEAVCIGPAPSKKSYLNIPAIISAA 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  340 KRIPVQAVWAGWGHASENPKLPELLCKNGVAFLGPPSEAMWALGDKIASTVVAQTLQVPTLPwsGSgltvewteddlqqg 419
Cdd:PRK08591   71 EITGADAIHPGYGFLSENADFAEICEDSGFTFIGPSAETIRLMGDKVTAKATMKKAGVPVVP--GS-------------- 134
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  420 krisvpedvydKGCVKDVDEGLEAAERIGFPLMIKASEGGGGKGIRKAESAEDFPILFRQVQSEIP---GSP-IFLMKLA 495
Cdd:PRK08591  135 -----------DGPVDDEEEALAIAKEIGYPVIIKATAGGGGRGMRVVRTEAELEKAFSMARAEAKaafGNPgVYMEKYL 203
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  496 QHARHLEVQILADQYGNAVSLFGRDCSIQRRHQKIVEEAPATIAPLAIFEFMEQCAIRLAKTVGYVSAGTVEYLYSQDGS 575
Cdd:PRK08591  204 ENPRHIEIQVLADGHGNAIHLGERDCSLQRRHQKVLEEAPSPAITEELRRKIGEAAVKAAKAIGYRGAGTIEFLYEKNGE 283
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  576 FHFLELNPRLQVEHPCTEMIADVNLPAAQLQIAMGVPLH-RLKDIRLlygespwgvtpisfetpsnpplaRGHVIAARIT 654
Cdd:PRK08591  284 FYFIEMNTRIQVEHPVTEMITGVDLVKEQIRIAAGEPLSiKQEDIVF-----------------------RGHAIECRIN 340
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  655 SENPDEGFKPSSGTVQelnfrssknvwGYFsvaATGGLH--------------EFADSQFGHCFSWGENREEAISNMVVA 720
Cdd:PRK08591  341 AEDPAKNFMPSPGKIT-----------RYH---PPGGPGvrvdsavytgytipPYYDSMIGKLIVHGETREEAIARMKRA 406
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*.
gi 767974033  721 LKELSIRGdFRTTVEYLINLLETESFQNNDIDTGWLDYLIAEKVQA 766
Cdd:PRK08591  407 LSEFVIDG-IKTTIPLHLRLLNDPNFQAGDYNIHYLEKKLALQEEK 451
pyruv_carbox TIGR01235
pyruvate carboxylase; This enzyme plays a role in gluconeogensis but not glycolysis. [Energy ...
262-757 1.20e-85

pyruvate carboxylase; This enzyme plays a role in gluconeogensis but not glycolysis. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 130302 [Multi-domain]  Cd Length: 1143  Bit Score: 307.52  E-value: 1.20e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033   262 KVLIANNGIAAVKCMRSIrrwayemfrNERAIRFVVMVTPED------LKANAEY-IKMADHYVPVpggpnnNNYANVEL 334
Cdd:TIGR01235    1 KILVANRGEIAIRVFRAA---------NELGIRTVAIYSEEDklslhrQKADESYqVGEGPDLGPI------EAYLSIDE 65
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033   335 IVDIAKRIPVQAVWAGWGHASENPKLPELLCKNGVAFLGPPSEAMWALGDKIASTVVAQTLQVPTLPWSgsgltvewted 414
Cdd:TIGR01235   66 IIRVAKLNGVDAIHPGYGFLSENSEFADACNKAGIIFIGPKAEVMDQLGDKVAARNLAIKAGVPVVPGT----------- 134
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033   415 dlqqgkrisvpedvydKGCVKDVDEGLEAAERIGFPLMIKASEGGGGKGIRKAESAEDFPILFRQVQSEIPGS----PIF 490
Cdd:TIGR01235  135 ----------------DGPPETMEEVLDFAAAIGYPVIIKASWGGGGRGMRVVRSEADVADAFQRAKSEAKAAfgndEVY 198
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033   491 LMKLAQHARHLEVQILADQYGNAVSLFGRDCSIQRRHQKIVEEAPATIAPLAIFEFMEQCAIRLAKTVGYVSAGTVEYLY 570
Cdd:TIGR01235  199 VEKLIERPRHIEVQLLGDKHGNVVHLFERDCSVQRRHQKVVEVAPAPYLSREVRDEIAEYAVKLAKAVNYINAGTVEFLV 278
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033   571 SQDGSFHFLELNPRLQVEHPCTEMIADVNLPAAQLQIAMGVPLHRLK-------DIRLlygespwgvtpisfetpsnppl 643
Cdd:TIGR01235  279 DNDGKFYFIEVNPRIQVEHTVTEEITGIDIVQAQIHIADGASLPTPQlgvpnqeDIRT---------------------- 336
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033   644 aRGHVIAARITSENPDEGFKPSSGTVQElnFRSSknvwGYFSVAATGG-------LHEFADSQFGHCFSWGENREEAISN 716
Cdd:TIGR01235  337 -NGYAIQCRVTTEDPANNFQPDTGRIEA--YRSA----GGFGIRLDGGnsyagaiITPYYDSLLVKVSAWASTPEEAAAK 409
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|.
gi 767974033   717 MVVALKELSIRGdFRTTVEYLINLLETESFQNNDIDTGWLD 757
Cdd:TIGR01235  410 MDRALREFRIRG-VKTNIPFLENVLGHPKFLDGSYDTRFID 449
CPSase_L_D2 pfam02786
Carbamoyl-phosphate synthase L chain, ATP binding domain; Carbamoyl-phosphate synthase ...
420-613 8.23e-55

Carbamoyl-phosphate synthase L chain, ATP binding domain; Carbamoyl-phosphate synthase catalyzes the ATP-dependent synthesis of carbamyl-phosphate from glutamine or ammonia and bicarbonate. This important enzyme initiates both the urea cycle and the biosynthesis of arginine and/or pyrimidines. The carbamoyl-phosphate synthase (CPS) enzyme in prokaryotes is a heterodimer of a small and large chain. The small chain promotes the hydrolysis of glutamine to ammonia, which is used by the large chain to synthesize carbamoyl phosphate. See pfam00988. The small chain has a GATase domain in the carboxyl terminus. See pfam00117. The ATP binding domain (this one) has an ATP-grasp fold.


Pssm-ID: 397079 [Multi-domain]  Cd Length: 209  Bit Score: 190.59  E-value: 8.23e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033   420 KRISVPEDVYDKGCVKDVDEGLEAAERIGFPLMIKASEGGGGKGIRKAESAEDFPILFRQVQSEIPGSP----IFLMKLA 495
Cdd:pfam02786   10 KEAGVPTVPGTAGPVETEEEALAAAKEIGYPVIIKAAFGGGGLGMGIARNEEELAELFALALAEAPAAFgnpqVLVEKSL 89
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033   496 QHARHLEVQILADQYGNAVSLFGRDCSIQRRHQKIVEEAPATIAPLAIFEFMEQCAIRLAKTVGYVSAGTVEYLYSQD-G 574
Cdd:pfam02786   90 KGPKHIEYQVLRDAHGNCITVCNRECSDQRRTQKSIEVAPSQTLTDEERQMLREAAVKIARHLGYVGAGTVEFALDPFsG 169
                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 767974033   575 SFHFLELNPRLQVEHPCTEMIADVNLPAAQLQIAMGVPL 613
Cdd:pfam02786  170 EYYFIEMNTRLQVEHALAEKATGYDLAKEAAKIALGYPL 208
Biotin_carb_C smart00878
Biotin carboxylase C-terminal domain; Biotin carboxylase is a component of the acetyl-CoA ...
651-757 8.91e-34

Biotin carboxylase C-terminal domain; Biotin carboxylase is a component of the acetyl-CoA carboxylase multi-component enzyme which catalyses the first committed step in fatty acid synthesis in animals, plants and bacteria. Most of the active site residues reported in reference are in this C-terminal domain.


Pssm-ID: 214878 [Multi-domain]  Cd Length: 107  Bit Score: 126.37  E-value: 8.91e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033    651 ARITSENPDEGFKPSSGTVQELNFRSSKNVwgYFSVAATGGLHE--FADSQFGHCFSWGENREEAISNMVVALKELSIRG 728
Cdd:smart00878    2 CRINAEDPANGFLPSPGRITRYRFPGGPGV--RVDSGVYEGYEVppYYDSMIAKLIVWGEDREEAIARLRRALDEFRIRG 79
                            90       100
                    ....*....|....*....|....*....
gi 767974033    729 dFRTTVEYLINLLETESFQNNDIDTGWLD 757
Cdd:smart00878   80 -VKTNIPFLRALLRHPDFRAGDVDTGFLE 107
MmdA COG4799
Acetyl-CoA carboxylase, carboxyltransferase component [Lipid transport and metabolism];
1704-2035 5.00e-26

Acetyl-CoA carboxylase, carboxyltransferase component [Lipid transport and metabolism];


Pssm-ID: 443827 [Multi-domain]  Cd Length: 508  Bit Score: 115.12  E-value: 5.00e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033 1704 EVGM-VAFKMRFKTQEYP-----------EGRDVIVIGNDITFRIGSFGP--GEDLLylRASEMARAEGIPKIYVAANSG 1769
Cdd:COG4799    51 ELGAlAGHRMYDDDDRVPgdgvvtgigtvDGRPVVVVANDFTVKGGSLGPmtAKKIL--RAQDIALENGLPVIYLVDSGG 128
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033 1770 ARIGMaeeikhmfhvawvdpedphkgfkylyltpqdytrisslnsvhckhieeggesrymitdiigkddglGVENLRGSG 1849
Cdd:COG4799   129 ARLQE------------------------------------------------------------------GVESFAGYG 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033 1850 MIAGESSLAYEEIVTISLVTCRAIGIGAYLVRLGQRVIQVE-NSHIILTGASALNKVLGREVytSNNQLGGVQiMHY--N 1926
Cdd:COG4799   143 RIFYRNARSSGGIPQISVIMGPCAAGGAYSPALSDFVIMVKgTSQMFLGGPPVVKAATGEEV--TAEELGGAD-VHArvS 219
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033 1927 GVSHITVPDDFEGVYTILEWLSYMPKDNHSPVPIITPTDP--IDREI-EFLP--SRAPYDPRWMLAGrphptlkgtwqsg 2001
Cdd:COG4799   220 GVADYLAEDEEEALALARRLLSYLPSNNLEDPPRAEPAPParDPEELyGIVPedPRKPYDMREVIAR------------- 286
                         330       340       350
                  ....*....|....*....|....*....|....
gi 767974033 2002 FFDHGSFKEIMAPWAQTVVTGRARLGGIPVGVIA 2035
Cdd:COG4799   287 LVDGGSFFEFKPLYGPNIVTGFARIDGRPVGIVA 320
Biotin_lipoyl pfam00364
Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue ...
895-961 6.71e-16

Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue binds biotin in one group and lipoic acid in the other. Note that the HMM does not currently recognize the Glycine cleavage system H proteins.


Pssm-ID: 395290 [Multi-domain]  Cd Length: 73  Bit Score: 74.17  E-value: 6.71e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767974033   895 TVLRSPSAGKL-----TQYTVEDGGHVEAGSSYAEMEVMKMIMTLNVQERGRVKYIKRP-GAVLEAGCVVARL 961
Cdd:pfam00364    1 TEIKSPMIGESvregvVEWLVKVGDKVKAGQPLAEVEAMKMEMEIPAPVAGVVKEILVPeGDTVEVGDPLAKI 73
biotinyl_domain cd06850
The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all ...
896-961 4.15e-14

The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, oxaloacetate decarboxylase, methylmalonyl-CoA decarboxylase, transcarboxylase and urea amidolyase. This domain functions in transferring CO2 from one subsite to another, allowing carboxylation, decarboxylation, or transcarboxylation. During this process, biotin is covalently attached to a specific lysine.


Pssm-ID: 133459 [Multi-domain]  Cd Length: 67  Bit Score: 68.98  E-value: 4.15e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767974033  896 VLRSPSAGKLTQYTVEDGGHVEAGSSYAEMEVMKMIMTLNVQERGRVKYIK-RPGAVLEAGCVVARL 961
Cdd:cd06850     1 EVTAPMPGTVVKVLVKEGDKVEAGQPLAVLEAMKMENEVTAPVAGVVKEILvKEGDQVEAGQLLVVI 67
PLN02820 PLN02820
3-methylcrotonyl-CoA carboxylase, beta chain
1854-2116 3.69e-04

3-methylcrotonyl-CoA carboxylase, beta chain


Pssm-ID: 178415 [Multi-domain]  Cd Length: 569  Bit Score: 45.57  E-value: 3.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033 1854 ESSLAYEEIVTISLVTCRAIGIGAYLVRLG-QRVIQVENSHIILTGASALNKVLGREVytSNNQLGGVQImH--YNGVSH 1930
Cdd:PLN02820  198 QARMSSAGIPQIALVLGSCTAGGAYVPAMAdESVIVKGNGTIFLAGPPLVKAATGEEV--SAEDLGGADV-HckVSGVSD 274
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033 1931 ITVPDDFEGV---YTILEWL-----SYMPKDNHSPVPII-TPTDPID--REIEFLPSRAPYDPRWMLAGrphptlkgtwq 1999
Cdd:PLN02820  275 HFAQDELHALaigRNIVKNLhlaakQGMENTLGSKNPEYkEPLYDVKelRGIVPADHKQSFDVRSVIAR----------- 343
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033 2000 sgFFDHGSFKEIMAPWAQTVVTGRARLGGIPVGVIAvetrtvevavpadpanldseakiiqqAGQVWFPDSAYKTAQAVK 2079
Cdd:PLN02820  344 --IVDGSEFDEFKKNYGTTLVTGFARIYGQPVGIIG--------------------------NNGILFTESALKGAHFIE 395
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 767974033 2080 DFNREKLPLMIFANWRGFSGGMKDMYDQVLKFGAYIV 2116
Cdd:PLN02820  396 LCAQRGIPLLFLQNITGFMVGSRSEASGIAKAGAKMV 432
PRK08225 PRK08225
acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
902-962 1.36e-03

acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated


Pssm-ID: 181304 [Multi-domain]  Cd Length: 70  Bit Score: 39.39  E-value: 1.36e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767974033  902 AGKLTQYTVEDGGHVEAGSSYAEMEVMKMIMTLNVQERGRVKYIKRP-GAVLEAGCVVARLE 962
Cdd:PRK08225    9 AGNVWKIVVKVGDTVEEGQDVVILESMKMEIPIVAEEAGTVKKINVQeGDFVNEGDVLLEIE 70
 
Name Accession Description Interval E-value
ACC_central pfam08326
Acetyl-CoA carboxylase, central region; The region featured in this family is found in various ...
962-1625 0e+00

Acetyl-CoA carboxylase, central region; The region featured in this family is found in various eukaryotic acetyl-CoA carboxylases, N-terminal to the catalytic domain (pfam01039). This enzyme (EC:6.4.1.2) is involved in the synthesis of long-chain fatty acids, as it catalyzes the rate-limiting step in this process.


Pssm-ID: 462429  Cd Length: 718  Bit Score: 898.08  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033   962 ELDDPSKVHPAEPFTGELPAQQTLPILGEKLHQVFHSVLENLTNVMSGFCL-----------------PE-PVF------ 1017
Cdd:pfam08326    1 ALDDPSRVKHAQPFEGQLPELGPPTVVGNKPHQRFAALLNILENILAGYDNqvimnetlkdlievlrdPElPYLewqeql 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  1018 ------------------------------SIKIATILDCHAATLQRKADREVFFINTQSIVQLVQRYRSGIRGYMKTVV 1067
Cdd:pfam08326   81 salsgripakleaslrqlverahsrsaefpAKQLRKILDKFLAELVLKADRDLFEATLAPLVDLVERYRNGLKGHEYSVF 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  1068 LDLLRRYLRVEHHFQQA--HYDKCVINLREQFKPDMSQVLDCIFSHAQVAKKNQLVIMLIDELCGP---DPSLSDELISI 1142
Cdd:pfam08326  161 ASLLEEYYDVEKLFSGGnvREEDVILKLRDENKDDLDKVVDIVLSHSRVSSKNKLILALLDHYRPNcpnVSNVAKELRPV 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  1143 LNELTQLSKSEHCKVALRARQILIASHLPSYELRHNQVESIFLSAIDMYGH--------QFCPENLKKLILSETTIFDVL 1214
Cdd:pfam08326  241 LKKLAELESRETAKVALKAREVLIQCALPSLEERKNQMEHILKSSVVESGYgesgwkhrEPSLEVLKELIDSKYTVFDVL 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  1215 PTFFYHANKVVCMASLEVYVRRGYIAYELNSLQHRQLPDGTCVVEFQFMLPSSHPNRMTVPISITNPDLLRH------ST 1288
Cdd:pfam08326  321 PPFFYHSDPWVSLAALEVYVRRAYRAYSLKSIQYHEGEDSPPIVSWQFQLPSSHSSEFGSPLSPSSDSSPPFkriasvSD 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  1289 ELFMDSGFSPLCQRMGAMVAFRRFEDFTRNFDEVISCFANVPKDTPLfseartslyseddcKSLREEPIHILNVSIQCAD 1368
Cdd:pfam08326  401 LSYLVNKSEDEPLRTGAMVAFKSLDDLEEALPRALEEFPSEPEESGE--------------SNSSDEPINVLNVAIRDAE 466
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  1369 HLE-DEALVPILRTFVQSKKNILVDYGLRRITFLIAQE-KEFPKFFTFRARDEFAEDRIYRHLEPALAFQLELNRMRNFD 1446
Cdd:pfam08326  467 GSDsDEELLERLEEILKENKEELLAAGVRRITFIIGRKdGQYPKYFTFRGPDNYEEDPIIRHIEPALAFQLELGRLSNFD 546
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  1447 LTAVPCANHKMHLYLGAAKVKEgvevTDHRFFIRAIIRHSDLITKEASFEYLQNEGERLLLEAMDELEVAfNNTSVRTDC 1526
Cdd:pfam08326  547 IKPVPTENRQIHLYEAVGKENP----TDKRFFVRAIIRPGRLRDDIPTAEYLISEAERLLNDILDALEVA-SIGNSNSDL 621
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  1527 NHIFLNFVPTVIMDPFKIEESVRYMVMRYGSRLWKLRVLQAEVKINIRQTTTGSAVPIRLFITNESGYYLDISLYKEVTD 1606
Cdd:pfam08326  622 NHIFLNFVPVFNVDPEDVEEAVGGFLERFGKRLWRLRVTQAEIRIIIRDPETGPPIPLRLVITNVSGYVVKVELYREVKD 701
                          730
                   ....*....|....*....
gi 767974033  1607 SRsGNIMFHSFGnKQGPQH 1625
Cdd:pfam08326  702 DK-GEWVFKSIG-KPGPMH 718
Carboxyl_trans pfam01039
Carboxyl transferase domain; All of the members in this family are biotin dependent ...
1717-2265 0e+00

Carboxyl transferase domain; All of the members in this family are biotin dependent carboxylases. The carboxyl transferase domain carries out the following reaction; transcarboxylation from biotin to an acceptor molecule. There are two recognized types of carboxyl transferase. One of them uses acyl-CoA and the other uses 2-oxoacid as the acceptor molecule of carbon dioxide. All of the members in this family utilize acyl-CoA as the acceptor molecule.


Pssm-ID: 426008 [Multi-domain]  Cd Length: 491  Bit Score: 618.50  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  1717 QEYPEGRDVIVIGNDITFRIGSFGPGEDLLYLRASEMARAEgIPKIYVAANSGARIGMAEEIKHMFHVAWVDPEDPHKGF 1796
Cdd:pfam01039    1 PEHPRGKLTARERIDLLLDPGSFGELEDLFFHRATEFGRKR-IPRDGVVTGSGAVIGRAVEVVAQDFTVFGGSLGPAKGE 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  1797 KylyLTPQDYTRISSlnsvhckhieegGESRYMITDIIGKDDGLGVENLRGSGMIAGESSLAYEEIVTISLVTCRAIGIG 1876
Cdd:pfam01039   80 K---ILRAMEIAIKT------------GLPLIGINDSGGARIQEGVENLRGSGKIFGRNSLASGVIPQISLIMGPCAGGG 144
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  1877 AYLVRLGQRVIQVEN-SHIILTGASALNKVLGrEVYTSNNQLGGVQIMHYNGVSHITVPDDFEGVYTILEWLSYMPKDNH 1955
Cdd:pfam01039  145 AYLPALGDFVIMVEGtSPMFLTGPPVIKKVTG-EEVTSEELGGATQHMTISGVSHLTALDDEDALELIRKWLSYLPKPAP 223
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  1956 S---PVPIITPTDPIDRE---IEFLPS--RAPYDPRWMLAGRphptlkgtwqsgfFDHGSFKEIMAPWAQTVVTGRARLG 2027
Cdd:pfam01039  224 NnrePVPIVPTKDPPDRDaplVSIVPDdpKKPYDVREVIAGI-------------VDEGEFFEIKPGYAKTVVTGFARLG 290
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  2028 GIPVGVIAVETRtvevavpadpanldseakiiQQAGqVWFPDSAYKTAQAVKDFNREKLPLMIFANWRGFSGGMKDMYDQ 2107
Cdd:pfam01039  291 GIPVGVVANQPR--------------------VGAG-VLFPDSADKAARFIRDCDAFNLPLVILADVPGFLPGQRQEYGG 349
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  2108 VLKFGAYIVDGLRQYKQPILIYIPPyaELRGGSWVVIDATINPLCIeMYADKESRGGVLEPEGTVEIKFRKKDLIKSMRR 2187
Cdd:pfam01039  350 ILKHGAKLLYALAEATVPKITVIPR--KAYGGAYVVMDSKINGADI-NFAWPTARIAVMGPEGAVEIKFRKEKAAAEMRG 426
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767974033  2188 IDPAYKKlmeqlgepdlsdkdrkdlEGRLKAREDLLLPIYHQVAVQFADFHDTPGRMLEKGVISDILEWKTARtFLYW 2265
Cdd:pfam01039  427 KDLAATR------------------KQKIAEYEEELSPPYVAAARGFADAVIDPGRTRAKLVIALAALWTKPR-FFPW 485
PccA COG4770
Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid transport and metabolism];
260-786 5.30e-132

Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid transport and metabolism];


Pssm-ID: 443802 [Multi-domain]  Cd Length: 466  Bit Score: 422.89  E-value: 5.30e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  260 IEKVLIANNGIAAVKCMRSIRrwayEMfrnerAIRFVVMVTPEDlkANAEYIKMADHYVPVPGGPNNNNYANVELIVDIA 339
Cdd:COG4770     2 FKKVLIANRGEIAVRIIRTCR----EL-----GIRTVAVYSDAD--RDALHVRLADEAVCIGPAPAAESYLNIDAIIAAA 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  340 KRIPVQAVWAGWGHASENPKLPELLCKNGVAFLGPPSEAMWALGDKIASTVVAQTLQVPTLPWSgsgltvewteddlqqg 419
Cdd:COG4770    71 KATGADAIHPGYGFLSENADFAEACEDAGIVFIGPSPEAIRAMGDKIAAKKLMKAAGVPVVPGS---------------- 134
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  420 krisvpedvydKGCVKDVDEGLEAAERIGFPLMIKASEGGGGKGIRKAESAEDFPILFRQVQSE---IPGSP-IFLMKLA 495
Cdd:COG4770   135 -----------DGPVQDAEEALAIAEEIGYPVLIKASAGGGGKGMRVVRSEEELEEAFESARREakaAFGDDrVYLEKYI 203
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  496 QHARHLEVQILADQYGNAVSLFGRDCSIQRRHQKIVEEAPATIAPLAIFEFMEQCAIRLAKTVGYVSAGTVEYLYSQDGS 575
Cdd:COG4770   204 ERPRHIEVQVLADKHGNVVHLGERDCSIQRRHQKVIEEAPSPALTEELRERMGEAAVRAAKAVGYVGAGTVEFLVDADGN 283
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  576 FHFLELNPRLQVEHPCTEMIADVNLPAAQLQIAMGVPLH-RLKDIRLlygespwgvtpisfetpsnpplaRGHVIAARIT 654
Cdd:COG4770   284 FYFLEMNTRLQVEHPVTEMVTGIDLVEEQIRIAAGEPLPfTQEDIKL-----------------------RGHAIECRIN 340
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  655 SENPDEGFKPSSGTVQELNFRSSknvwgyFSVAATGGLHE------FADSQFGHCFSWGENREEAISNMVVALKELSIRG 728
Cdd:COG4770   341 AEDPARGFLPSPGTITRLRPPGG------PGVRVDSGVYEgyeippYYDSMIAKLIVWGPDREEAIARMRRALAEFVIEG 414
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 767974033  729 dFRTTVEYLINLLETESFQNNDIDTGWLDYLIAEKVQAEKPDimlgvvcgALNVADAM 786
Cdd:COG4770   415 -VKTNIPFLRALLAHPDFRAGDVDTGFIERELAELLAAAAPE--------ELALAAAM 463
PRK08591 PRK08591
acetyl-CoA carboxylase biotin carboxylase subunit; Validated
260-766 7.04e-112

acetyl-CoA carboxylase biotin carboxylase subunit; Validated


Pssm-ID: 236307 [Multi-domain]  Cd Length: 451  Bit Score: 364.51  E-value: 7.04e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  260 IEKVLIANNGIAAVKCMRSIRrwayemfrnERAIRFVVMVTPEDlkANAEYIKMADHYVPVPGGPNNNNYANVELIVDIA 339
Cdd:PRK08591    2 FDKILIANRGEIALRIIRACK---------ELGIKTVAVHSTAD--RDALHVQLADEAVCIGPAPSKKSYLNIPAIISAA 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  340 KRIPVQAVWAGWGHASENPKLPELLCKNGVAFLGPPSEAMWALGDKIASTVVAQTLQVPTLPwsGSgltvewteddlqqg 419
Cdd:PRK08591   71 EITGADAIHPGYGFLSENADFAEICEDSGFTFIGPSAETIRLMGDKVTAKATMKKAGVPVVP--GS-------------- 134
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  420 krisvpedvydKGCVKDVDEGLEAAERIGFPLMIKASEGGGGKGIRKAESAEDFPILFRQVQSEIP---GSP-IFLMKLA 495
Cdd:PRK08591  135 -----------DGPVDDEEEALAIAKEIGYPVIIKATAGGGGRGMRVVRTEAELEKAFSMARAEAKaafGNPgVYMEKYL 203
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  496 QHARHLEVQILADQYGNAVSLFGRDCSIQRRHQKIVEEAPATIAPLAIFEFMEQCAIRLAKTVGYVSAGTVEYLYSQDGS 575
Cdd:PRK08591  204 ENPRHIEIQVLADGHGNAIHLGERDCSLQRRHQKVLEEAPSPAITEELRRKIGEAAVKAAKAIGYRGAGTIEFLYEKNGE 283
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  576 FHFLELNPRLQVEHPCTEMIADVNLPAAQLQIAMGVPLH-RLKDIRLlygespwgvtpisfetpsnpplaRGHVIAARIT 654
Cdd:PRK08591  284 FYFIEMNTRIQVEHPVTEMITGVDLVKEQIRIAAGEPLSiKQEDIVF-----------------------RGHAIECRIN 340
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  655 SENPDEGFKPSSGTVQelnfrssknvwGYFsvaATGGLH--------------EFADSQFGHCFSWGENREEAISNMVVA 720
Cdd:PRK08591  341 AEDPAKNFMPSPGKIT-----------RYH---PPGGPGvrvdsavytgytipPYYDSMIGKLIVHGETREEAIARMKRA 406
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*.
gi 767974033  721 LKELSIRGdFRTTVEYLINLLETESFQNNDIDTGWLDYLIAEKVQA 766
Cdd:PRK08591  407 LSEFVIDG-IKTTIPLHLRLLNDPNFQAGDYNIHYLEKKLALQEEK 451
PRK12999 PRK12999
pyruvate carboxylase; Reviewed
258-757 1.07e-104

pyruvate carboxylase; Reviewed


Pssm-ID: 237263 [Multi-domain]  Cd Length: 1146  Bit Score: 365.23  E-value: 1.07e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  258 RVIEKVLIANNGIAAVKCMRSIrrwayemfrNERAIRFVVMVTPED------LKANAEYIkmadhyVPVPGGPNNNnYAN 331
Cdd:PRK12999    3 KKIKKVLVANRGEIAIRIFRAA---------TELGIRTVAIYSEEDklslhrFKADEAYL------IGEGKHPVRA-YLD 66
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  332 VELIVDIAKRIPVQAVWAGWGHASENPKLPELLCKNGVAFLGPPSEAMWALGDKIASTVVAQTLQVPTLPWSGSGltvew 411
Cdd:PRK12999   67 IDEIIRVAKQAGVDAIHPGYGFLSENPEFARACAEAGITFIGPTAEVLRLLGDKVAARNAAIKAGVPVIPGSEGP----- 141
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  412 teddlqqgkrisvpedvydkgcVKDVDEGLEAAERIGFPLMIKASEGGGGKGIRKAESAEDFPILFRQVQSEIP---GSP 488
Cdd:PRK12999  142 ----------------------IDDIEEALEFAEEIGYPIMLKASAGGGGRGMRIVRSEEELEEAFERAKREAKaafGND 199
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  489 -IFLMKLAQHARHLEVQILADQYGNAVSLFGRDCSIQRRHQKIVEEAPATIAPLAIFEFMEQCAIRLAKTVGYVSAGTVE 567
Cdd:PRK12999  200 eVYLEKYVENPRHIEVQILGDKHGNVVHLYERDCSVQRRHQKVVEIAPAPGLSEELRERICEAAVKLARAVGYVNAGTVE 279
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  568 YLYSQDGSFHFLELNPRLQVEHPCTEMIADVNLPAAQLQIAMGVPLHRL-------KDIRLlygespwgvtpisfetpsn 640
Cdd:PRK12999  280 FLVDADGNFYFIEVNPRIQVEHTVTEEVTGIDIVQSQILIAEGATLHDLeigipsqEDIRL------------------- 340
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  641 pplaRGHVIAARITSENPDEGFKPSSGTVQElnFRSSknvwGYFSVAATGGLHeFADSQFGHCF--------SWGENREE 712
Cdd:PRK12999  341 ----RGYAIQCRITTEDPANNFMPDTGRITA--YRSP----GGFGVRLDGGNA-FAGAEITPYYdsllvkltAWGRTFEQ 409
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*
gi 767974033  713 AISNMVVALKELSIRGdFRTTVEYLINLLETESFQNNDIDTGWLD 757
Cdd:PRK12999  410 AVARMRRALREFRIRG-VKTNIPFLENVLKHPDFRAGDYTTSFID 453
PycA COG1038
Pyruvate carboxylase [Energy production and conversion]; Pyruvate carboxylase is part of the ...
260-757 3.81e-102

Pyruvate carboxylase [Energy production and conversion]; Pyruvate carboxylase is part of the Pathway/BioSystem: Urea cycle


Pssm-ID: 440660 [Multi-domain]  Cd Length: 1144  Bit Score: 357.47  E-value: 3.81e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  260 IEKVLIANNG-IAavkcmrsIR--RWAYEMfrnerAIRFVVMVTPED------LKANAEY-IKMADHyvPVpggpnnNNY 329
Cdd:COG1038     4 IKKVLVANRGeIA-------IRvfRAATEL-----GIRTVAIYSEEDryslhrFKADEAYlIGEGKG--PV------DAY 63
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  330 ANVELIVDIAKRIPVQAVWAGWGHASENPKLPELLCKNGVAFLGPPSEAMWALGDKIASTVVAQTLQVPTLPwsGSgltv 409
Cdd:COG1038    64 LDIEEIIRVAKEKGVDAIHPGYGFLSENPEFARACEEAGITFIGPSPEVLEMLGDKVAARAAAIEAGVPVIP--GT---- 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  410 ewteddlqqgkrisvpedvydKGCVKDVDEGLEAAERIGFPLMIKASEGGGGKGIRKAESAEDFPILFRQVQSEIP---G 486
Cdd:COG1038   138 ---------------------EGPVDDLEEALAFAEEIGYPVMLKAAAGGGGRGMRVVRSEEELEEAFESARREAKaafG 196
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  487 SP-IFLMKLAQHARHLEVQILADQYGNAVSLFGRDCSIQRRHQKIVEEAPATIAPLAIFEFMEQCAIRLAKTVGYVSAGT 565
Cdd:COG1038   197 DDeVFLEKYIERPKHIEVQILGDKHGNIVHLFERDCSVQRRHQKVVEIAPAPNLDEELREAICEAAVKLAKAVGYVNAGT 276
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  566 VEYLYSQDGSFHFLELNPRLQVEHPCTEMIADVNLPAAQLQIAMGVPLH-------RLKDIRLlygespwgvtpisfetp 638
Cdd:COG1038   277 VEFLVDDDGNFYFIEVNPRIQVEHTVTEEVTGIDIVQSQILIAEGYSLDdpeigipSQEDIRL----------------- 339
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  639 snpplaRGHVIAARITSENPDEGFKPSSGTVQElnFRSSknvwGYFSV---AATGglheFA--------DSQFGHCFSWG 707
Cdd:COG1038   340 ------NGYAIQCRITTEDPANNFMPDTGRITA--YRSA----GGFGIrldGGNA----YTgavitpyyDSLLVKVTAWG 403
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|
gi 767974033  708 ENREEAISNMVVALKELSIRGdFRTTVEYLINLLETESFQNNDIDTGWLD 757
Cdd:COG1038   404 RTFEEAIRKMRRALREFRIRG-VKTNIPFLENVLNHPDFLAGECTTSFID 452
PRK08654 PRK08654
acetyl-CoA carboxylase biotin carboxylase subunit;
261-757 6.79e-101

acetyl-CoA carboxylase biotin carboxylase subunit;


Pssm-ID: 236325 [Multi-domain]  Cd Length: 499  Bit Score: 334.64  E-value: 6.79e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  261 EKVLIANNGIAAVKCMRSIRrwayemfrnERAIRFVVMVTPEDlkANAEYIKMADHYVPVPGGPNNNNYANVELIVDIAK 340
Cdd:PRK08654    3 KKILIANRGEIAIRVMRACR---------ELGIKTVAVYSEAD--KNALFVKYADEAYPIGPAPPSKSYLNIERIIDVAK 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  341 RIPVQAVWAGWGHASENPKLPELLCKNGVAFLGPPSEAMWALGDKIASTVVAQTLQVPTLPWSgsgltvewteddlqqgk 420
Cdd:PRK08654   72 KAGADAIHPGYGFLAENPEFAKACEKAGIVFIGPSSDVIEAMGSKINAKKLMKKAGVPVLPGT----------------- 134
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  421 risvpedvydKGCVKDVDEGLEAAERIGFPLMIKASEGGGGKGIRKAESAEDFPILFRQVQSeIPGS-----PIFLMKLA 495
Cdd:PRK08654  135 ----------EEGIEDIEEAKEIAEEIGYPVIIKASAGGGGIGMRVVYSEEELEDAIESTQS-IAQSafgdsTVFIEKYL 203
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  496 QHARHLEVQILADQYGNAVSLFGRDCSIQRRHQKIVEEAPATIAPLAIFEFMEQCAIRLAKTVGYVSAGTVEYLYSqDGS 575
Cdd:PRK08654  204 EKPRHIEIQILADKHGNVIHLGDRECSIQRRHQKLIEEAPSPIMTPELRERMGEAAVKAAKAINYENAGTVEFLYS-NGN 282
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  576 FHFLELNPRLQVEHPCTEMIADVNLPAAQLQIAMGVPL-HRLKDIRLlygespwgvtpisfetpsnpplaRGHVIAARIT 654
Cdd:PRK08654  283 FYFLEMNTRLQVEHPITEMVTGIDIVKEQIKIAAGEELsFKQEDITI-----------------------RGHAIECRIN 339
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  655 SENPDEGFKPSSGTVQelNFRSSknvwGYFSVAATGGLH------EFADSQFGHCFSWGENREEAISNMVVALKELSIRG 728
Cdd:PRK08654  340 AEDPLNDFAPSPGKIK--RYRSP----GGPGVRVDSGVHmgyeipPYYDSMISKLIVWGRTREEAIARMRRALYEYVIVG 413
                         490       500
                  ....*....|....*....|....*....
gi 767974033  729 dFRTTVEYLINLLETESFQNNDIDTGWLD 757
Cdd:PRK08654  414 -VKTNIPFHKAVMENENFVRGNLHTHFIE 441
PRK06111 PRK06111
acetyl-CoA carboxylase biotin carboxylase subunit; Validated
260-759 1.38e-100

acetyl-CoA carboxylase biotin carboxylase subunit; Validated


Pssm-ID: 180406 [Multi-domain]  Cd Length: 450  Bit Score: 331.99  E-value: 1.38e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  260 IEKVLIANNGIAAVKCMRSIRRWAyemfrneraIRFVVMVTPEDlkANAEYIKMADHYVPVPGGPNNNNYANVELIVDIA 339
Cdd:PRK06111    2 FQKVLIANRGEIAVRIIRTCQKLG---------IRTVAIYSEAD--RDALHVKMADEAYLIGGPRVQESYLNLEKIIEIA 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  340 KRIPVQAVWAGWGHASENPKLPELLCKNGVAFLGPPSEAMWALGDKIASTVVAQTLQVPTLPWSGSGLTvewteddlqqg 419
Cdd:PRK06111   71 KKTGAEAIHPGYGLLSENASFAERCKEEGIVFIGPSADIIAKMGSKIEARRAMQAAGVPVVPGITTNLE----------- 139
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  420 krisvpedvydkgcvkDVDEGLEAAERIGFPLMIKASEGGGGKGIRKAESAEDFPILFRQVQSEIP---GSP-IFLMKLA 495
Cdd:PRK06111  140 ----------------DAEEAIAIARQIGYPVMLKASAGGGGIGMQLVETEQELTKAFESNKKRAAnffGNGeMYIEKYI 203
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  496 QHARHLEVQILADQYGNAVSLFGRDCSIQRRHQKIVEEAPATIAPLAIFEFMEQCAIRLAKTVGYVSAGTVEYLYSQDGS 575
Cdd:PRK06111  204 EDPRHIEIQLLADTHGNTVYLWERECSVQRRHQKVIEEAPSPFLDEETRKAMGERAVQAAKAIGYTNAGTIEFLVDEQKN 283
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  576 FHFLELNPRLQVEHPCTEMIADVNLPAAQLQIAMGVPL-HRLKDIRLlygespwgvtpisfetpsnpplaRGHVIAARIT 654
Cdd:PRK06111  284 FYFLEMNTRLQVEHPVTEEITGIDLVEQQLRIAAGEKLsFTQDDIKR-----------------------SGHAIEVRIY 340
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  655 SENPDEgFKPSSGTVQELNFRSSKNVWGYFSVAATGGLHEFADSQFGHCFSWGENREEAISNMVVALKELSIRGdFRTTV 734
Cdd:PRK06111  341 AEDPKT-FFPSPGKITDLTLPGGEGVRHDHAVENGVTVTPFYDPMIAKLIAHGETREEAISRLHDALEELKVEG-IKTNI 418
                         490       500
                  ....*....|....*....|....*.
gi 767974033  735 EYLINLLETESFQNNDIDTGWL-DYL 759
Cdd:PRK06111  419 PLLLQVLEDPVFKAGGYTTGFLtKQL 444
PRK05586 PRK05586
acetyl-CoA carboxylase biotin carboxylase subunit;
260-756 4.23e-92

acetyl-CoA carboxylase biotin carboxylase subunit;


Pssm-ID: 180150 [Multi-domain]  Cd Length: 447  Bit Score: 307.41  E-value: 4.23e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  260 IEKVLIANNGIAAVKCMRSIRrwayemfrnERAIRFVVMVTPEDlkANAEYIKMADHYVPVPGGPNNNNYANVELIVDIA 339
Cdd:PRK05586    2 FKKILIANRGEIAVRIIRACR---------EMGIETVAVYSEAD--KDALHVQLADEAVCIGPASSKDSYLNIQNIISAT 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  340 KRIPVQAVWAGWGHASENPKLPELLCKNGVAFLGPPSEAMWALGDKIASTVVAQTLQVPTLPWSgsgltvewteddlqqg 419
Cdd:PRK05586   71 VLTGAQAIHPGFGFLSENSKFAKMCKECNIVFIGPDSETIELMGNKSNAREIMIKAGVPVVPGS---------------- 134
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  420 krisvpedvydKGCVKDVDEGLEAAERIGFPLMIKASEGGGGKGIRKAESAEDFPILFRQVQSEIPGS----PIFLMKLA 495
Cdd:PRK05586  135 -----------EGEIENEEEALEIAKEIGYPVMVKASAGGGGRGIRIVRSEEELIKAFNTAKSEAKAAfgddSMYIEKFI 203
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  496 QHARHLEVQILADQYGNAVSLFGRDCSIQRRHQKIVEEAPATIAPLAIFEFMEQCAIRLAKTVGYVSAGTVEYLYSQDGS 575
Cdd:PRK05586  204 ENPKHIEFQILGDNYGNVVHLGERDCSLQRRNQKVLEEAPSPVMTEELRKKMGEIAVKAAKAVNYKNAGTIEFLLDKDGN 283
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  576 FHFLELNPRLQVEHPCTEMIADVNLPAAQLQIAMGVPLH-RLKDIRLlygespwgvtpisfetpsnpplaRGHVIAARIT 654
Cdd:PRK05586  284 FYFMEMNTRIQVEHPITEMITGVDLVKEQIKIAYGEKLSiKQEDIKI-----------------------NGHSIECRIN 340
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  655 SENPDEGFKPSSGTVQELNFRSSKNVwgYFSVAATGG--LHEFADSQFGHCFSWGENREEAISNMVVALKELSIRGdFRT 732
Cdd:PRK05586  341 AEDPKNGFMPCPGKIEELYIPGGLGV--RVDSAVYSGytIPPYYDSMIGKLIVYGKDREEAIQKMKRALGEFIIEG-VNT 417
                         490       500
                  ....*....|....*....|....
gi 767974033  733 TVEYLINLLETESFQNNDIDTGWL 756
Cdd:PRK05586  418 NIDFQFIILEDEEFIKGTYDTSFI 441
PRK12833 PRK12833
acetyl-CoA carboxylase biotin carboxylase subunit; Provisional
260-766 2.39e-90

acetyl-CoA carboxylase biotin carboxylase subunit; Provisional


Pssm-ID: 183781 [Multi-domain]  Cd Length: 467  Bit Score: 303.21  E-value: 2.39e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  260 IEKVLIANNGIAAVKCMRSIRrwayemfrnERAIRFVVMVTPEDLKANAeyIKMADHYVPVPGGPNNNNYANVELIVDIA 339
Cdd:PRK12833    5 IRKVLVANRGEIAVRIIRAAR---------ELGMRTVAACSDADRDSLA--ARMADEAVHIGPSHAAKSYLNPAAILAAA 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  340 KRIPVQAVWAGWGHASENPKLPELLCKNGVAFLGPPSEAMWALGDKIASTVVAQTLQVPTLPWSgsgltvewteddlqqg 419
Cdd:PRK12833   74 RQCGADAIHPGYGFLSENAAFAEAVEAAGLIFVGPDAQTIRTMGDKARARRTARRAGVPTVPGS---------------- 137
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  420 krisvpedvydKGCVKDVDEGLEAAERIGFPLMIKASEGGGGKGIRKAESAED----FPILFRQVQSEIPGSPIFLMKLA 495
Cdd:PRK12833  138 -----------DGVVASLDAALEVAARIGYPLMIKAAAGGGGRGIRVAHDAAQlaaeLPLAQREAQAAFGDGGVYLERFI 206
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  496 QHARHLEVQILADQYgNAVSLFGRDCSIQRRHQKIVEEAPATIAPLAIFEFMEQCAIRLAKTVGYVSAGTVEYLY-SQDG 574
Cdd:PRK12833  207 ARARHIEVQILGDGE-RVVHLFERECSLQRRRQKILEEAPSPSLTPAQRDALCASAVRLARQVGYRGAGTLEYLFdDARG 285
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  575 SFHFLELNPRLQVEHPCTEMIADVNLPAAQLQIAMGVPLH-RLKDIRLlygespwgvtpisfetpsnpplaRGHVIAARI 653
Cdd:PRK12833  286 EFYFIEMNTRIQVEHPVTEAITGIDLVQEMLRIADGEPLRfAQGDIAL-----------------------RGAALECRI 342
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  654 TSENPDEGFKPSSGTVQELNF------RSSKNVWGYFSVAAtgglheFADSQFGHCFSWGENREEAISNMVVALKELSIR 727
Cdd:PRK12833  343 NAEDPLRDFFPNPGRIDALVWpqgpgvRVDSLLYPGYRVPP------FYDSLLAKLIVHGEDRAAALARAARALRELRID 416
                         490       500       510
                  ....*....|....*....|....*....|....*....
gi 767974033  728 GdFRTTVEYLINLLETESFQNNDIDTGWLDYLIAEKVQA 766
Cdd:PRK12833  417 G-MKTTAPLHRALLADADVRAGRFHTNFLEAWLAEWRAA 454
PRK08462 PRK08462
acetyl-CoA carboxylase biotin carboxylase subunit;
260-757 8.90e-90

acetyl-CoA carboxylase biotin carboxylase subunit;


Pssm-ID: 236269 [Multi-domain]  Cd Length: 445  Bit Score: 300.51  E-value: 8.90e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  260 IEKVLIANNGIAAVKCMRSIRrwayEMfrNERAIrfVVMVTPEDlkaNAEYIKMADHYVPVPGGPNNNNYANVELIVDIA 339
Cdd:PRK08462    4 IKRILIANRGEIALRAIRTIQ----EM--GKEAI--AIYSTADK---DALYLKYADAKICIGGAKSSESYLNIPAIISAA 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  340 KRIPVQAVWAGWGHASENPKLPELLCKNGVAFLGPPSEAMWALGDKIASTVVAQTLQVPTLPWSgsgltvewteddlqqg 419
Cdd:PRK08462   73 EIFEADAIFPGYGFLSENQNFVEICSHHNIKFIGPSVEVMALMSDKSKAKEVMKRAGVPVIPGS---------------- 136
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  420 krisvpedvydKGCVKDVDEGLEAAERIGFPLMIKASEGGGGKGIRKAESAEDFPILFRQVQSEIPGS----PIFLMKLA 495
Cdd:PRK08462  137 -----------DGALKSYEEAKKIAKEIGYPVILKAAAGGGGRGMRVVEDESDLENLYLAAESEALSAfgdgTMYMEKFI 205
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  496 QHARHLEVQILADQYGNAVSLFGRDCSIQRRHQKIVEEAPATIAPLAIFEFMEQCAIRLAKTVGYVSAGTVEYLYSQDGS 575
Cdd:PRK08462  206 NNPRHIEVQILGDKHGNVIHVGERDCSLQRRHQKLIEESPAVVLDEKTRERLHETAIKAAKAIGYEGAGTFEFLLDSNLD 285
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  576 FHFLELNPRLQVEHPCTEMIADVNLPAAQLQIAMGVPLHRLKDIRLlygespwgvtpisfetpsnpplaRGHVIAARITS 655
Cdd:PRK08462  286 FYFMEMNTRLQVEHTVSEMVSGLDLIEWMIKIAEGEELPSQESIKL-----------------------KGHAIECRITA 342
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  656 ENPdEGFKPSSGTVQEL------NFRSSKNVWGYFSVAAtgglheFADSQFGHCFSWGENREEAISNMVVALKELSIRGd 729
Cdd:PRK08462  343 EDP-KKFYPSPGKITKWiapggrNVRMDSHAYAGYVVPP------YYDSMIGKLIVWGEDRNRAIAKMKRALKEFKVEG- 414
                         490       500
                  ....*....|....*....|....*...
gi 767974033  730 FRTTVEYLINLLETESFQNNDIDTGWLD 757
Cdd:PRK08462  415 IKTTIPFHLEMMENADFINNKYDTKYLE 442
PRK07178 PRK07178
acetyl-CoA carboxylase biotin carboxylase subunit;
259-757 1.10e-85

acetyl-CoA carboxylase biotin carboxylase subunit;


Pssm-ID: 180865 [Multi-domain]  Cd Length: 472  Bit Score: 289.69  E-value: 1.10e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  259 VIEKVLIANNGIAAVKCMRSIRrwayemfrnERAIRFVVMVTPEDlkANAEYIKMADHYV-----PVPGgpnnnnYANVE 333
Cdd:PRK07178    1 MIKKILIANRGEIAVRIVRACA---------EMGIRSVAIYSEAD--RHALHVKRADEAYsigadPLAG------YLNPR 63
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  334 LIVDIAKRIPVQAVWAGWGHASENPKLPELLCKNGVAFLGPPSEAMWALGDKIASTVVAQTLQVPTLPWSgsgltvewte 413
Cdd:PRK07178   64 RLVNLAVETGCDALHPGYGFLSENAELAEICAERGIKFIGPSAEVIRRMGDKTEARRAMIKAGVPVTPGS---------- 133
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  414 ddlqqgkrisvpedvydKGCVKDVDEGLEAAERIGFPLMIKASEGGGGKGIRKAESAEDFPILFRQVQSEIP---GSP-I 489
Cdd:PRK07178  134 -----------------EGNLADLDEALAEAERIGYPVMLKATSGGGGRGIRRCNSREELEQNFPRVISEATkafGSAeV 196
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  490 FLMKLAQHARHLEVQILADQYGNAVSLFGRDCSIQRRHQKIVEEAPATIAPLAIFEFMEQCAIRLAKTVGYVSAGTVEYL 569
Cdd:PRK07178  197 FLEKCIVNPKHIEVQILADSHGNVVHLFERDCSIQRRNQKLIEIAPSPQLTPEQRAYIGDLAVRAAKAVGYENAGTVEFL 276
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  570 YSQDGSFHFLELNPRLQVEHPCTEMIADVNLPAAQLQIAMGVPL-HRLKDIRLlygespwgvtpisfetpsnpplaRGHV 648
Cdd:PRK07178  277 LDADGEVYFMEMNTRVQVEHTITEEITGIDIVREQIRIASGLPLsYKQEDIQH-----------------------RGFA 333
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  649 IAARITSENPDEGFKPSSGTVQElnfrssknvwgYFSVAATG---------GLH--EFADSQFGHCFSWGENREEAISNM 717
Cdd:PRK07178  334 LQFRINAEDPKNDFLPSFGKITR-----------YYAPGGPGvrtdtaiytGYTipPYYDSMCAKLIVWALTWEEALDRG 402
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|
gi 767974033  718 VVALKELSIRGdFRTTVEYLINLLETESFQNNDIDTGWLD 757
Cdd:PRK07178  403 RRALDDMRVQG-VKTTIPYYQEILRNPEFRSGQFNTSFVE 441
pyruv_carbox TIGR01235
pyruvate carboxylase; This enzyme plays a role in gluconeogensis but not glycolysis. [Energy ...
262-757 1.20e-85

pyruvate carboxylase; This enzyme plays a role in gluconeogensis but not glycolysis. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 130302 [Multi-domain]  Cd Length: 1143  Bit Score: 307.52  E-value: 1.20e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033   262 KVLIANNGIAAVKCMRSIrrwayemfrNERAIRFVVMVTPED------LKANAEY-IKMADHYVPVpggpnnNNYANVEL 334
Cdd:TIGR01235    1 KILVANRGEIAIRVFRAA---------NELGIRTVAIYSEEDklslhrQKADESYqVGEGPDLGPI------EAYLSIDE 65
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033   335 IVDIAKRIPVQAVWAGWGHASENPKLPELLCKNGVAFLGPPSEAMWALGDKIASTVVAQTLQVPTLPWSgsgltvewted 414
Cdd:TIGR01235   66 IIRVAKLNGVDAIHPGYGFLSENSEFADACNKAGIIFIGPKAEVMDQLGDKVAARNLAIKAGVPVVPGT----------- 134
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033   415 dlqqgkrisvpedvydKGCVKDVDEGLEAAERIGFPLMIKASEGGGGKGIRKAESAEDFPILFRQVQSEIPGS----PIF 490
Cdd:TIGR01235  135 ----------------DGPPETMEEVLDFAAAIGYPVIIKASWGGGGRGMRVVRSEADVADAFQRAKSEAKAAfgndEVY 198
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033   491 LMKLAQHARHLEVQILADQYGNAVSLFGRDCSIQRRHQKIVEEAPATIAPLAIFEFMEQCAIRLAKTVGYVSAGTVEYLY 570
Cdd:TIGR01235  199 VEKLIERPRHIEVQLLGDKHGNVVHLFERDCSVQRRHQKVVEVAPAPYLSREVRDEIAEYAVKLAKAVNYINAGTVEFLV 278
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033   571 SQDGSFHFLELNPRLQVEHPCTEMIADVNLPAAQLQIAMGVPLHRLK-------DIRLlygespwgvtpisfetpsnppl 643
Cdd:TIGR01235  279 DNDGKFYFIEVNPRIQVEHTVTEEITGIDIVQAQIHIADGASLPTPQlgvpnqeDIRT---------------------- 336
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033   644 aRGHVIAARITSENPDEGFKPSSGTVQElnFRSSknvwGYFSVAATGG-------LHEFADSQFGHCFSWGENREEAISN 716
Cdd:TIGR01235  337 -NGYAIQCRVTTEDPANNFQPDTGRIEA--YRSA----GGFGIRLDGGnsyagaiITPYYDSLLVKVSAWASTPEEAAAK 409
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|.
gi 767974033   717 MVVALKELSIRGdFRTTVEYLINLLETESFQNNDIDTGWLD 757
Cdd:TIGR01235  410 MDRALREFRIRG-VKTNIPFLENVLGHPKFLDGSYDTRFID 449
PRK08463 PRK08463
acetyl-CoA carboxylase subunit A; Validated
260-780 4.65e-68

acetyl-CoA carboxylase subunit A; Validated


Pssm-ID: 169452 [Multi-domain]  Cd Length: 478  Bit Score: 238.94  E-value: 4.65e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  260 IEKVLIANNGIAAVKCMRSIRrwayemfrnERAIRFVVMVTPEDlkANAEYIKMADHYVPVPGGPNNNnYANVELIVDIA 339
Cdd:PRK08463    2 IHKILIANRGEIAVRVIRACR---------DLHIKSVAIYTEPD--RECLHVKIADEAYRIGTDPIKG-YLDVKRIVEIA 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  340 KRIPVQAVWAGWGHASENPKLPELLCKNGVAFLGPPSEAMWALGDKIASTVVAQTLQVPTLPwsgsgltvewteddlqqg 419
Cdd:PRK08463   70 KACGADAIHPGYGFLSENYEFAKAVEDAGIIFIGPKSEVIRKMGNKNIARYLMKKNGIPIVP------------------ 131
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  420 krisvpedvydkGCVKDVDEGLEA----AERIGFPLMIKASEGGGGKGIRKAESAEDFPILF----RQVQSEIPGSPIFL 491
Cdd:PRK08463  132 ------------GTEKLNSESMEEikifARKIGYPVILKASGGGGGRGIRVVHKEEDLENAFesckREALAYFNNDEVFM 199
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  492 MKLAQHARHLEVQILADQYGNAVSLFGRDCSIQRRHQKIVEEAPATIAPLAIFEFMEQCAIRLAKTVGYVSAGTVEYLYS 571
Cdd:PRK08463  200 EKYVVNPRHIEFQILGDNYGNIIHLCERDCSIQRRHQKVIEIAPCPSISDNLRKTMGVTAVAAAKAVGYTNAGTIEFLLD 279
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  572 QDGSFHFLELNPRLQVEHPCTEMIADVNLPAAQLQIAMGVPLhrlkdirllygespwgvtpisfETPSNPPLARGHVIAA 651
Cdd:PRK08463  280 DYNRFYFMEMNTRIQVEHGVTEEITGIDLIVRQIRIAAGEIL----------------------DLEQSDIKPRGFAIEA 337
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  652 RITSENPDEGFKPSSGTVQEL------NFRSSKNVWGYFSVAAtgglheFADSQFGHCFSWGENREEAISNMVVALKELS 725
Cdd:PRK08463  338 RITAENVWKNFIPSPGKITEYypalgpSVRVDSHIYKDYTIPP------YYDSMLAKLIVKATSYDLAVNKLERALKEFV 411
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767974033  726 IRGdFRTTVEYLINLLETESFQNNDIDTGWLDYLIAEKVQA------EKPDIMLGVVCGAL 780
Cdd:PRK08463  412 IDG-IRTTIPFLIAITKTREFRRGYFDTSYIETHMQELLEKtedrhqENKEEVIAAIAAAL 471
CPSase_L_D2 pfam02786
Carbamoyl-phosphate synthase L chain, ATP binding domain; Carbamoyl-phosphate synthase ...
420-613 8.23e-55

Carbamoyl-phosphate synthase L chain, ATP binding domain; Carbamoyl-phosphate synthase catalyzes the ATP-dependent synthesis of carbamyl-phosphate from glutamine or ammonia and bicarbonate. This important enzyme initiates both the urea cycle and the biosynthesis of arginine and/or pyrimidines. The carbamoyl-phosphate synthase (CPS) enzyme in prokaryotes is a heterodimer of a small and large chain. The small chain promotes the hydrolysis of glutamine to ammonia, which is used by the large chain to synthesize carbamoyl phosphate. See pfam00988. The small chain has a GATase domain in the carboxyl terminus. See pfam00117. The ATP binding domain (this one) has an ATP-grasp fold.


Pssm-ID: 397079 [Multi-domain]  Cd Length: 209  Bit Score: 190.59  E-value: 8.23e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033   420 KRISVPEDVYDKGCVKDVDEGLEAAERIGFPLMIKASEGGGGKGIRKAESAEDFPILFRQVQSEIPGSP----IFLMKLA 495
Cdd:pfam02786   10 KEAGVPTVPGTAGPVETEEEALAAAKEIGYPVIIKAAFGGGGLGMGIARNEEELAELFALALAEAPAAFgnpqVLVEKSL 89
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033   496 QHARHLEVQILADQYGNAVSLFGRDCSIQRRHQKIVEEAPATIAPLAIFEFMEQCAIRLAKTVGYVSAGTVEYLYSQD-G 574
Cdd:pfam02786   90 KGPKHIEYQVLRDAHGNCITVCNRECSDQRRTQKSIEVAPSQTLTDEERQMLREAAVKIARHLGYVGAGTVEFALDPFsG 169
                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 767974033   575 SFHFLELNPRLQVEHPCTEMIADVNLPAAQLQIAMGVPL 613
Cdd:pfam02786  170 EYYFIEMNTRLQVEHALAEKATGYDLAKEAAKIALGYPL 208
Biotin_carb_N pfam00289
Biotin carboxylase, N-terminal domain; This domain is structurally related to the PreATP-grasp ...
260-378 3.08e-43

Biotin carboxylase, N-terminal domain; This domain is structurally related to the PreATP-grasp domain. The family contains the N-terminus of biotin carboxylase enzymes, and propionyl-CoA carboxylase A chain.


Pssm-ID: 425585 [Multi-domain]  Cd Length: 108  Bit Score: 153.41  E-value: 3.08e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033   260 IEKVLIANNGIAAVKCMRSIRRWAyemfrneraIRFVVMVTPEDlkANAEYIKMADHYVPVPGGPNNNNYANVELIVDIA 339
Cdd:pfam00289    1 IKKVLIANRGEIAVRIIRACRELG---------IRTVAVYSEAD--ANSLHVRLADEAVCLGPGPASESYLNIDAIIDAA 69
                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 767974033   340 KRIPVQAVWAGWGHASENPKLPELLCKNGVAFLGPPSEA 378
Cdd:pfam00289   70 KETGADAIHPGYGFLSENAEFARACEEAGIIFIGPSPEA 108
AccC COG0439
Biotin carboxylase [Lipid transport and metabolism]; Biotin carboxylase is part of the Pathway ...
332-612 1.44e-39

Biotin carboxylase [Lipid transport and metabolism]; Biotin carboxylase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440208 [Multi-domain]  Cd Length: 263  Bit Score: 148.87  E-value: 1.44e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  332 VELIVDIAKRIPVQAVWAGWGHASEnpKLPELLCKNGVAflGPPSEAMWALGDKIASTVVAQTLQVPTlPWSGsgltvew 411
Cdd:COG0439     6 IAAAAELARETGIDAVLSESEFAVE--TAAELAEELGLP--GPSPEAIRAMRDKVLMREALAAAGVPV-PGFA------- 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  412 teddlqqgkrisvpedvydkgCVKDVDEGLEAAERIGFPLMIKASEGGGGKGIRKAESAEDFPILFRQVQSEI----PGS 487
Cdd:COG0439    74 ---------------------LVDSPEEALAFAEEIGYPVVVKPADGAGSRGVRVVRDEEELEAALAEARAEAkagsPNG 132
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  488 PIFLMKLAQHaRHLEVQILADQyGNAVSlfgrdCSIQRRHQK---IVE---EAPATIAPlAIFEFMEQCAIRLAKTVGYV 561
Cdd:COG0439   133 EVLVEEFLEG-REYSVEGLVRD-GEVVV-----CSITRKHQKppyFVElghEAPSPLPE-ELRAEIGELVARALRALGYR 204
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767974033  562 -SAGTVEYLYSQDGSFHFLELNPRLQVEH--PCTEMIADVNLPAAQLQIAMGVP 612
Cdd:COG0439   205 rGAFHTEFLLTPDGEPYLIEINARLGGEHipPLTELATGVDLVREQIRLALGEP 258
Biotin_carb_C smart00878
Biotin carboxylase C-terminal domain; Biotin carboxylase is a component of the acetyl-CoA ...
651-757 8.91e-34

Biotin carboxylase C-terminal domain; Biotin carboxylase is a component of the acetyl-CoA carboxylase multi-component enzyme which catalyses the first committed step in fatty acid synthesis in animals, plants and bacteria. Most of the active site residues reported in reference are in this C-terminal domain.


Pssm-ID: 214878 [Multi-domain]  Cd Length: 107  Bit Score: 126.37  E-value: 8.91e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033    651 ARITSENPDEGFKPSSGTVQELNFRSSKNVwgYFSVAATGGLHE--FADSQFGHCFSWGENREEAISNMVVALKELSIRG 728
Cdd:smart00878    2 CRINAEDPANGFLPSPGRITRYRFPGGPGV--RVDSGVYEGYEVppYYDSMIAKLIVWGEDREEAIARLRRALDEFRIRG 79
                            90       100
                    ....*....|....*....|....*....
gi 767974033    729 dFRTTVEYLINLLETESFQNNDIDTGWLD 757
Cdd:smart00878   80 -VKTNIPFLRALLRHPDFRAGDVDTGFLE 107
Biotin_carb_C pfam02785
Biotin carboxylase C-terminal domain; Biotin carboxylase is a component of the acetyl-CoA ...
651-757 6.03e-30

Biotin carboxylase C-terminal domain; Biotin carboxylase is a component of the acetyl-CoA carboxylase multi-component enzyme which catalyzes the first committed step in fatty acid synthesis in animals, plants and bacteria. Most of the active site residues reported in reference are in this C-terminal domain.


Pssm-ID: 426981 [Multi-domain]  Cd Length: 108  Bit Score: 115.67  E-value: 6.03e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033   651 ARITSENPDEGFKPSSGTVQELNFRSSKNVWGYFSVAATGGLHEFADSQFGHCFSWGENREEAISNMVVALKELSIRGdF 730
Cdd:pfam02785    2 ARIYAEDPDNNFLPSPGKVTRYRFPGGPGVRVDSGVYAGYTVSPYYDSMIAKLIVHGPTREEAIARLRRALAEFRIEG-V 80
                           90       100
                   ....*....|....*....|....*..
gi 767974033   731 RTTVEYLINLLETESFQNNDIDTGWLD 757
Cdd:pfam02785   81 KTNIPFLRAILEHPDFRAGEVDTGFLE 107
MmdA COG4799
Acetyl-CoA carboxylase, carboxyltransferase component [Lipid transport and metabolism];
1704-2035 5.00e-26

Acetyl-CoA carboxylase, carboxyltransferase component [Lipid transport and metabolism];


Pssm-ID: 443827 [Multi-domain]  Cd Length: 508  Bit Score: 115.12  E-value: 5.00e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033 1704 EVGM-VAFKMRFKTQEYP-----------EGRDVIVIGNDITFRIGSFGP--GEDLLylRASEMARAEGIPKIYVAANSG 1769
Cdd:COG4799    51 ELGAlAGHRMYDDDDRVPgdgvvtgigtvDGRPVVVVANDFTVKGGSLGPmtAKKIL--RAQDIALENGLPVIYLVDSGG 128
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033 1770 ARIGMaeeikhmfhvawvdpedphkgfkylyltpqdytrisslnsvhckhieeggesrymitdiigkddglGVENLRGSG 1849
Cdd:COG4799   129 ARLQE------------------------------------------------------------------GVESFAGYG 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033 1850 MIAGESSLAYEEIVTISLVTCRAIGIGAYLVRLGQRVIQVE-NSHIILTGASALNKVLGREVytSNNQLGGVQiMHY--N 1926
Cdd:COG4799   143 RIFYRNARSSGGIPQISVIMGPCAAGGAYSPALSDFVIMVKgTSQMFLGGPPVVKAATGEEV--TAEELGGAD-VHArvS 219
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033 1927 GVSHITVPDDFEGVYTILEWLSYMPKDNHSPVPIITPTDP--IDREI-EFLP--SRAPYDPRWMLAGrphptlkgtwqsg 2001
Cdd:COG4799   220 GVADYLAEDEEEALALARRLLSYLPSNNLEDPPRAEPAPParDPEELyGIVPedPRKPYDMREVIAR------------- 286
                         330       340       350
                  ....*....|....*....|....*....|....
gi 767974033 2002 FFDHGSFKEIMAPWAQTVVTGRARLGGIPVGVIA 2035
Cdd:COG4799   287 LVDGGSFFEFKPLYGPNIVTGFARIDGRPVGIVA 320
Biotin_lipoyl pfam00364
Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue ...
895-961 6.71e-16

Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue binds biotin in one group and lipoic acid in the other. Note that the HMM does not currently recognize the Glycine cleavage system H proteins.


Pssm-ID: 395290 [Multi-domain]  Cd Length: 73  Bit Score: 74.17  E-value: 6.71e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767974033   895 TVLRSPSAGKL-----TQYTVEDGGHVEAGSSYAEMEVMKMIMTLNVQERGRVKYIKRP-GAVLEAGCVVARL 961
Cdd:pfam00364    1 TEIKSPMIGESvregvVEWLVKVGDKVKAGQPLAEVEAMKMEMEIPAPVAGVVKEILVPeGDTVEVGDPLAKI 73
biotinyl_domain cd06850
The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all ...
896-961 4.15e-14

The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, oxaloacetate decarboxylase, methylmalonyl-CoA decarboxylase, transcarboxylase and urea amidolyase. This domain functions in transferring CO2 from one subsite to another, allowing carboxylation, decarboxylation, or transcarboxylation. During this process, biotin is covalently attached to a specific lysine.


Pssm-ID: 133459 [Multi-domain]  Cd Length: 67  Bit Score: 68.98  E-value: 4.15e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767974033  896 VLRSPSAGKLTQYTVEDGGHVEAGSSYAEMEVMKMIMTLNVQERGRVKYIK-RPGAVLEAGCVVARL 961
Cdd:cd06850     1 EVTAPMPGTVVKVLVKEGDKVEAGQPLAVLEAMKMENEVTAPVAGVVKEILvKEGDQVEAGQLLVVI 67
COG3919 COG3919
Predicted ATP-dependent carboligase, ATP-grasp superfamily [General function prediction only];
314-613 2.91e-11

Predicted ATP-dependent carboligase, ATP-grasp superfamily [General function prediction only];


Pssm-ID: 443124 [Multi-domain]  Cd Length: 382  Bit Score: 68.03  E-value: 2.91e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  314 ADHYVPVPGgPNNNNYANVELIVDIAKRIPVQAVWA---GWGHA-SEN-PKLPEllcknGVAFLGPPSEAMWALGDKIAS 388
Cdd:COG3919    48 VDEVVVVPD-PGDDPEAFVDALLELAERHGPDVLIPtgdEYVELlSRHrDELEE-----HYRLPYPDADLLDRLLDKERF 121
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  389 TVVAQTLQVPtlpwsgsgltvewteddlqqgkrisVPEDVYdkgcVKDVDEGLEAAERIGFPLMIKASEG--------GG 460
Cdd:COG3919   122 YELAEELGVP-------------------------VPKTVV----LDSADDLDALAEDLGFPVVVKPADSvgydelsfPG 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  461 GKGIRKAESAEDFPILFRQ---------VQSEIPG--SPIFLmklaqharhleVQILADQYGNAVSLFGrdcsiqrrHQK 529
Cdd:COG3919   173 KKKVFYVDDREELLALLRRiaaagyeliVQEYIPGddGEMRG-----------LTAYVDRDGEVVATFT--------GRK 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  530 IVEeAPATIAPLAIFEF-----MEQCAIRLAKTVGYVSAGTVEYLY-SQDGSFHFLELNPRLQVEHPCTEmIADVNLPAA 603
Cdd:COG3919   234 LRH-YPPAGGNSAARESvddpeLEEAARRLLEALGYHGFANVEFKRdPRDGEYKLIEINPRFWRSLYLAT-AAGVNFPYL 311
                         330
                  ....*....|
gi 767974033  604 QLQIAMGVPL 613
Cdd:COG3919   312 LYDDAVGRPL 321
CPSaseII_lrg TIGR01369
carbamoyl-phosphate synthase, large subunit; Carbamoyl-phosphate synthase (CPSase) catalyzes ...
408-639 1.25e-07

carbamoyl-phosphate synthase, large subunit; Carbamoyl-phosphate synthase (CPSase) catalyzes the first committed step in pyrimidine, arginine, and urea biosynthesis. In general, it is a glutamine-dependent enzyme, EC 6.3.5.5, termed CPSase II in eukaryotes. An exception is the mammalian mitochondrial urea-cycle form, CPSase I, in which the glutamine amidotransferase domain active site Cys on the small subunit has been lost, and the enzyme is ammonia-dependent. In both CPSase I and the closely related, glutamine-dependent CPSase III (allosterically activated by acetyl-glutamate) demonstrated in some other vertebrates, the small and large chain regions are fused in a single polypeptide chain. This model represents the large chain of glutamine-hydrolysing carbamoyl-phosphate synthases, or the corresponding regions of larger, multifunctional proteins, as found in all domains of life, and CPSase I forms are considered exceptions within the family. In several thermophilic species (Methanobacterium thermoautotrophicum, Methanococcus jannaschii, Aquifex aeolicus), the large subunit appears split, at different points, into two separate genes. [Purines, pyrimidines, nucleosides, and nucleotides, Pyrimidine ribonucleotide biosynthesis]


Pssm-ID: 273581 [Multi-domain]  Cd Length: 1050  Bit Score: 57.32  E-value: 1.25e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033   408 TVEWTED-DLQQGKRISVPEDVYDKGCVKDVDEGLEAAERIGFPLMIKASE--GGGGKGIrkAESAEDFPILFRQVQSEI 484
Cdd:TIGR01369  121 AIKKAEDrELFREAMKEIGEPVPESEIAHSVEEALAAAKEIGYPVIVRPAFtlGGTGGGI--AYNREELKEIAERALSAS 198
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033   485 PGSPIFLMKLAQHARHLEVQILADQYGNAVSLfgrdCSIQR-----RH--QKIVeeapatIAP---LAIFEF--MEQCAI 552
Cdd:TIGR01369  199 PINQVLVEKSLAGWKEIEYEVMRDSNDNCITV----CNMENfdpmgVHtgDSIV------VAPsqtLTDKEYqmLRDASI 268
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033   553 RLAKTVGYVSAGTVEY-LYSQDGSFHFLELNPRLQ---------VEHPctemIADVnlpAAQLqiAMGVPLHRLK-DIRl 621
Cdd:TIGR01369  269 KIIRELGIEGGCNVQFaLNPDSGRYYVIEVNPRVSrssalaskaTGYP----IAKV---AAKL--AVGYTLDELKnPVT- 338
                          250
                   ....*....|....*...
gi 767974033   622 lygespwGVTPISFEtPS 639
Cdd:TIGR01369  339 -------GTTPASFE-PS 348
PLN02735 PLN02735
carbamoyl-phosphate synthase
432-584 8.57e-07

carbamoyl-phosphate synthase


Pssm-ID: 215391 [Multi-domain]  Cd Length: 1102  Bit Score: 54.78  E-value: 8.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  432 GCVKDVDEGLEAAERIGFPLMIKASEGGGGKGIRKAESAEDfpiLFRQVQSEI---PGSPIFLMKLAQHARHLEVQILAD 508
Cdd:PLN02735  721 GIARSEADALAIAKRIGYPVVVRPSYVLGGRAMEIVYSDDK---LKTYLETAVevdPERPVLVDKYLSDATEIDVDALAD 797
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  509 QYGNAV-----------SLFGRD--CSIQRrhQKIVEEAPATIaplaifefmEQCAIRLAKTVGYVSAGTVEYLYSQDGS 575
Cdd:PLN02735  798 SEGNVViggimehieqaGVHSGDsaCSLPT--QTIPSSCLATI---------RDWTTKLAKRLNVCGLMNCQYAITPSGE 866

                  ....*....
gi 767974033  576 FHFLELNPR 584
Cdd:PLN02735  867 VYIIEANPR 875
CPSaseII_lrg TIGR01369
carbamoyl-phosphate synthase, large subunit; Carbamoyl-phosphate synthase (CPSase) catalyzes ...
434-613 2.99e-06

carbamoyl-phosphate synthase, large subunit; Carbamoyl-phosphate synthase (CPSase) catalyzes the first committed step in pyrimidine, arginine, and urea biosynthesis. In general, it is a glutamine-dependent enzyme, EC 6.3.5.5, termed CPSase II in eukaryotes. An exception is the mammalian mitochondrial urea-cycle form, CPSase I, in which the glutamine amidotransferase domain active site Cys on the small subunit has been lost, and the enzyme is ammonia-dependent. In both CPSase I and the closely related, glutamine-dependent CPSase III (allosterically activated by acetyl-glutamate) demonstrated in some other vertebrates, the small and large chain regions are fused in a single polypeptide chain. This model represents the large chain of glutamine-hydrolysing carbamoyl-phosphate synthases, or the corresponding regions of larger, multifunctional proteins, as found in all domains of life, and CPSase I forms are considered exceptions within the family. In several thermophilic species (Methanobacterium thermoautotrophicum, Methanococcus jannaschii, Aquifex aeolicus), the large subunit appears split, at different points, into two separate genes. [Purines, pyrimidines, nucleosides, and nucleotides, Pyrimidine ribonucleotide biosynthesis]


Pssm-ID: 273581 [Multi-domain]  Cd Length: 1050  Bit Score: 52.69  E-value: 2.99e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033   434 VKDVDEGLEAAERIGFPLMIKASEGGGGKGIRKAESAEDFPILFRQVQSEIPGSPIFLMKLAQHARHLEVQILADqyGNA 513
Cdd:TIGR01369  690 ATSVEEAVEFASEIGYPVLVRPSYVLGGRAMEIVYNEEELRRYLEEAVAVSPEHPVLIDKYLEDAVEVDVDAVSD--GEE 767
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033   514 VSLFGrdcsIQrRHqkiVEEA-----------PATIAPLAIFEFMEQCAIRLAKTVGYVSAGTVEYLYSqDGSFHFLELN 582
Cdd:TIGR01369  768 VLIPG----IM-EH---IEEAgvhsgdstcvlPPQTLSAEIVDRIKDIVRKIAKELNVKGLMNIQFAVK-DGEVYVIEVN 838
                          170       180       190
                   ....*....|....*....|....*....|.
gi 767974033   583 PRLQVEHPCTEMIADVNLPAAQLQIAMGVPL 613
Cdd:TIGR01369  839 PRASRTVPFVSKATGVPLAKLAVRVMLGKKL 869
CarB COG0458
Carbamoylphosphate synthase large subunit [Amino acid transport and metabolism, Nucleotide ...
434-584 3.63e-05

Carbamoylphosphate synthase large subunit [Amino acid transport and metabolism, Nucleotide transport and metabolism]; Carbamoylphosphate synthase large subunit is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440226 [Multi-domain]  Cd Length: 536  Bit Score: 49.11  E-value: 3.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  434 VKDVDEGLEAAERIGFPLMIKASE--GGGGKGIrkAESAEDFPILFRQVQSEIPGSPIFLMKLAQHARHLEVQILADQYG 511
Cdd:COG0458   135 ATSVEEALAIAEEIGYPVIVRPSYvlGGRGMGI--VYNEEELEEYLERALKVSPDHPVLIDESLLGAKEIEVDVVRDGED 212
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  512 NAVSLfgrdCSIQrrHqkiVEEA------PATIAP-----LAIFEFMEQCAIRLAKTVGYVSAGTVEYLYsQDGSFHFLE 580
Cdd:COG0458   213 NVIIV----GIME--H---IEPAgvhsgdSICVAPpqtlsDKEYQRLRDATLKIARALGVVGLCNIQFAV-DDGRVYVIE 282

                  ....
gi 767974033  581 LNPR 584
Cdd:COG0458   283 VNPR 286
PLN02820 PLN02820
3-methylcrotonyl-CoA carboxylase, beta chain
1854-2116 3.69e-04

3-methylcrotonyl-CoA carboxylase, beta chain


Pssm-ID: 178415 [Multi-domain]  Cd Length: 569  Bit Score: 45.57  E-value: 3.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033 1854 ESSLAYEEIVTISLVTCRAIGIGAYLVRLG-QRVIQVENSHIILTGASALNKVLGREVytSNNQLGGVQImH--YNGVSH 1930
Cdd:PLN02820  198 QARMSSAGIPQIALVLGSCTAGGAYVPAMAdESVIVKGNGTIFLAGPPLVKAATGEEV--SAEDLGGADV-HckVSGVSD 274
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033 1931 ITVPDDFEGV---YTILEWL-----SYMPKDNHSPVPII-TPTDPID--REIEFLPSRAPYDPRWMLAGrphptlkgtwq 1999
Cdd:PLN02820  275 HFAQDELHALaigRNIVKNLhlaakQGMENTLGSKNPEYkEPLYDVKelRGIVPADHKQSFDVRSVIAR----------- 343
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033 2000 sgFFDHGSFKEIMAPWAQTVVTGRARLGGIPVGVIAvetrtvevavpadpanldseakiiqqAGQVWFPDSAYKTAQAVK 2079
Cdd:PLN02820  344 --IVDGSEFDEFKKNYGTTLVTGFARIYGQPVGIIG--------------------------NNGILFTESALKGAHFIE 395
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 767974033 2080 DFNREKLPLMIFANWRGFSGGMKDMYDQVLKFGAYIV 2116
Cdd:PLN02820  396 LCAQRGIPLLFLQNITGFMVGSRSEASGIAKAGAKMV 432
PRK08225 PRK08225
acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
902-962 1.36e-03

acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated


Pssm-ID: 181304 [Multi-domain]  Cd Length: 70  Bit Score: 39.39  E-value: 1.36e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767974033  902 AGKLTQYTVEDGGHVEAGSSYAEMEVMKMIMTLNVQERGRVKYIKRP-GAVLEAGCVVARLE 962
Cdd:PRK08225    9 AGNVWKIVVKVGDTVEEGQDVVILESMKMEIPIVAEEAGTVKKINVQeGDFVNEGDVLLEIE 70
PRK12767 PRK12767
carbamoyl phosphate synthase-like protein; Provisional
422-584 1.99e-03

carbamoyl phosphate synthase-like protein; Provisional


Pssm-ID: 237195 [Multi-domain]  Cd Length: 326  Bit Score: 42.95  E-value: 1.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  422 ISVPeDVYDKGCVKDVDEGLEAAErIGFPLMIKASEGGGGKGIRKAESAEDFPILFRQ-----VQSEIPGSPIflmklaq 496
Cdd:PRK12767  124 IPTP-KSYLPESLEDFKAALAKGE-LQFPLFVKPRDGSASIGVFKVNDKEELEFLLEYvpnliIQEFIEGQEY------- 194
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033  497 harhlEVQILADQYGNAVSLFGRdcsiqRR--------HQKIVEEAPAtiaplaIFEFMEqcaiRLAKTVGYVSAGTVEY 568
Cdd:PRK12767  195 -----TVDVLCDLNGEVISIVPR-----KRievragetSKGVTVKDPE------LFKLAE----RLAEALGARGPLNIQC 254
                         170
                  ....*....|....*.
gi 767974033  569 LYSqDGSFHFLELNPR 584
Cdd:PRK12767  255 FVT-DGEPYLFEINPR 269
carB PRK05294
carbamoyl-phosphate synthase large subunit;
434-473 2.43e-03

carbamoyl-phosphate synthase large subunit;


Pssm-ID: 235393 [Multi-domain]  Cd Length: 1066  Bit Score: 43.16  E-value: 2.43e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 767974033  434 VKDVDEGLEAAERIGFPLMIKAS--EGGGGKGIrkAESAEDF 473
Cdd:PRK05294  149 AHSMEEALEVAEEIGYPVIIRPSftLGGTGGGI--AYNEEEL 188
PRK07051 PRK07051
biotin carboxyl carrier domain-containing protein;
895-962 3.20e-03

biotin carboxyl carrier domain-containing protein;


Pssm-ID: 180811 [Multi-domain]  Cd Length: 80  Bit Score: 38.46  E-value: 3.20e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767974033  895 TVLRSPSAGklTQYTVEDGGHVEAGSSYAEMEVMKMIMTLNVQERGRV-KYIKRPGAVLEAGCVVARLE 962
Cdd:PRK07051   13 TFYRRPSPD--APPYVEVGDAVAAGDVVGLIEVMKQFTEVEAEAAGRVvEFLVEDGEPVEAGQVLARIE 79
ATP-grasp_3 pfam02655
ATP-grasp domain; No functional information or experimental verification of function is known ...
442-586 9.16e-03

ATP-grasp domain; No functional information or experimental verification of function is known in this family. This family appears to be an ATP-grasp domain (Pers. obs. A Bateman).


Pssm-ID: 396979 [Multi-domain]  Cd Length: 160  Bit Score: 39.29  E-value: 9.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767974033   442 EAAERIGFPLMIKASEGGGGKGIRKAE--SAEDFPILFRQVQSEIPGSPIFLMKLAQHARHLEVQIlADQY-GNAVSLF- 517
Cdd:pfam02655   25 EELLREEKKYVVKPRDGCGGEGVRKVEngREDEAFIENVLVQEFIEGEPLSVSLLSDGEKALPLSV-NRQYiDNGGSGFv 103
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767974033   518 ---GRDCSIQRRHQKIVEEApatiaplaifefmEQCAIRLAKTVGYVSagtVEYLYSqDGSFHFLELNPRLQ 586
Cdd:pfam02655  104 yagNVTPSRTELKEEIIELA-------------EEVVECLPGLRGYVG---VDLVLK-DNEPYVIEVNPRIT 158
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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