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Conserved domains on  [gi|767961509|ref|XP_011537550|]
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phosphoinositide 3-kinase adapter protein 1 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DBB pfam14545
Dof, BCAP, and BANK (DBB) motif,; The DBB domain is named from the Drosophila (Downstream of ...
 180-318 1.20e-66

Dof, BCAP, and BANK (DBB) motif,; The DBB domain is named from the Drosophila (Downstream of FGFR - Dof, also known as Heartbroken or Stumps) protein, the BANKS and BCAP, both signalling in B-cell pathway, proteins. This domain defines a minimal region required for mediating Dof dimerization. Since this domain can interact both with itself and with a region in the C-terminal part of the molecule, it may mediate either intermolecular or intramolecular interactions. Mutants lacking this domain disrupt FGFR signal transduction and fibroblast growth-factor signalling. The DBB domain of BCAP mediates BCAP TIR dimerization and negatively regulates TLR signalling.


:

Pssm-ID: 464205  Cd Length: 139  Bit Score: 217.46  E-value: 1.20e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961509  180 VVQPDRIRCGAETTVYVIVRCKLDDRVATEAEFSPEDSPSVRMEAKVENEYTISVKAPNLSSGNVSLKIYSGDLVVCETV 259
Cdd:pfam14545   1 LVQPSRIKCGSQNKVFILLKEPLDKEDSVEVEFSGNNEQIKRVNAKLENPYTLQFNAPDFPSGLVSVTVYSGGLSLGTRQ 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767961509  260 ISYYTDMEEIGNLLSNAANPVEFMCQAFKIVPYNTETLDKLLTESLKNNIPASGLHLFG 318
Cdd:pfam14545  81 VKYYSRMEEIEQLLKSVADPVEFMCQAFGISSNDTEKLDQLLTSSLKKNMPPSGFHLLG 139
TIR_3 pfam18567
Toll/interleukin-1 receptor domain; This is a Toll/interleukin-1 receptor (TIR) domain found ...
 11-141 7.23e-58

Toll/interleukin-1 receptor domain; This is a Toll/interleukin-1 receptor (TIR) domain found in the N-terminal region of B-cell adaptor for phosphoinositide 3-kinase (BCAP). BCAP functions in linking the B-cell receptor (BCR) and the co-receptor CD19 to the activation of PI3K via interaction with the SH2 domains on the regulatory p85 subunit. BCAP TIR associates with the MAL/TIRAP adaptor and the TIR domains of Toll-like receptors (TLRs).


:

Pssm-ID: 436583  Cd Length: 128  Bit Score: 193.21  E-value: 7.23e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961509   11 DILIVYSPDAEEWCQYLQTLFLSSrqVRSQKILTHRLGpEASFSAEDLSLFLSTRCVVVLLSAELVQHFHkPALLPLLQR 90
Cdd:pfam18567   1 DILIVYEEEAEEWATYLQSLFVSS--VRELGILLYNLE-DTSLEHLDLLSFKSYKCILLLLSAGLLECLK-PKVLEFLQR 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767961509   91 AFHPPHRVVRLLCGVRDS-EEFLDFFPDWAHWQELTCDDEPETYVAAVKKAI 141
Cdd:pfam18567  77 VLHPPHRVVVLLCGVHESyELLEEFFSDWEIWQEISCDDEPEEYISAVRKII 128
 
Name Accession Description Interval E-value
DBB pfam14545
Dof, BCAP, and BANK (DBB) motif,; The DBB domain is named from the Drosophila (Downstream of ...
 180-318 1.20e-66

Dof, BCAP, and BANK (DBB) motif,; The DBB domain is named from the Drosophila (Downstream of FGFR - Dof, also known as Heartbroken or Stumps) protein, the BANKS and BCAP, both signalling in B-cell pathway, proteins. This domain defines a minimal region required for mediating Dof dimerization. Since this domain can interact both with itself and with a region in the C-terminal part of the molecule, it may mediate either intermolecular or intramolecular interactions. Mutants lacking this domain disrupt FGFR signal transduction and fibroblast growth-factor signalling. The DBB domain of BCAP mediates BCAP TIR dimerization and negatively regulates TLR signalling.


Pssm-ID: 464205  Cd Length: 139  Bit Score: 217.46  E-value: 1.20e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961509  180 VVQPDRIRCGAETTVYVIVRCKLDDRVATEAEFSPEDSPSVRMEAKVENEYTISVKAPNLSSGNVSLKIYSGDLVVCETV 259
Cdd:pfam14545   1 LVQPSRIKCGSQNKVFILLKEPLDKEDSVEVEFSGNNEQIKRVNAKLENPYTLQFNAPDFPSGLVSVTVYSGGLSLGTRQ 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767961509  260 ISYYTDMEEIGNLLSNAANPVEFMCQAFKIVPYNTETLDKLLTESLKNNIPASGLHLFG 318
Cdd:pfam14545  81 VKYYSRMEEIEQLLKSVADPVEFMCQAFGISSNDTEKLDQLLTSSLKKNMPPSGFHLLG 139
TIR_3 pfam18567
Toll/interleukin-1 receptor domain; This is a Toll/interleukin-1 receptor (TIR) domain found ...
 11-141 7.23e-58

Toll/interleukin-1 receptor domain; This is a Toll/interleukin-1 receptor (TIR) domain found in the N-terminal region of B-cell adaptor for phosphoinositide 3-kinase (BCAP). BCAP functions in linking the B-cell receptor (BCR) and the co-receptor CD19 to the activation of PI3K via interaction with the SH2 domains on the regulatory p85 subunit. BCAP TIR associates with the MAL/TIRAP adaptor and the TIR domains of Toll-like receptors (TLRs).


Pssm-ID: 436583  Cd Length: 128  Bit Score: 193.21  E-value: 7.23e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961509   11 DILIVYSPDAEEWCQYLQTLFLSSrqVRSQKILTHRLGpEASFSAEDLSLFLSTRCVVVLLSAELVQHFHkPALLPLLQR 90
Cdd:pfam18567   1 DILIVYEEEAEEWATYLQSLFVSS--VRELGILLYNLE-DTSLEHLDLLSFKSYKCILLLLSAGLLECLK-PKVLEFLQR 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767961509   91 AFHPPHRVVRLLCGVRDS-EEFLDFFPDWAHWQELTCDDEPETYVAAVKKAI 141
Cdd:pfam18567  77 VLHPPHRVVVLLCGVHESyELLEEFFSDWEIWQEISCDDEPEEYISAVRKII 128
 
Name Accession Description Interval E-value
DBB pfam14545
Dof, BCAP, and BANK (DBB) motif,; The DBB domain is named from the Drosophila (Downstream of ...
 180-318 1.20e-66

Dof, BCAP, and BANK (DBB) motif,; The DBB domain is named from the Drosophila (Downstream of FGFR - Dof, also known as Heartbroken or Stumps) protein, the BANKS and BCAP, both signalling in B-cell pathway, proteins. This domain defines a minimal region required for mediating Dof dimerization. Since this domain can interact both with itself and with a region in the C-terminal part of the molecule, it may mediate either intermolecular or intramolecular interactions. Mutants lacking this domain disrupt FGFR signal transduction and fibroblast growth-factor signalling. The DBB domain of BCAP mediates BCAP TIR dimerization and negatively regulates TLR signalling.


Pssm-ID: 464205  Cd Length: 139  Bit Score: 217.46  E-value: 1.20e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961509  180 VVQPDRIRCGAETTVYVIVRCKLDDRVATEAEFSPEDSPSVRMEAKVENEYTISVKAPNLSSGNVSLKIYSGDLVVCETV 259
Cdd:pfam14545   1 LVQPSRIKCGSQNKVFILLKEPLDKEDSVEVEFSGNNEQIKRVNAKLENPYTLQFNAPDFPSGLVSVTVYSGGLSLGTRQ 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767961509  260 ISYYTDMEEIGNLLSNAANPVEFMCQAFKIVPYNTETLDKLLTESLKNNIPASGLHLFG 318
Cdd:pfam14545  81 VKYYSRMEEIEQLLKSVADPVEFMCQAFGISSNDTEKLDQLLTSSLKKNMPPSGFHLLG 139
TIR_3 pfam18567
Toll/interleukin-1 receptor domain; This is a Toll/interleukin-1 receptor (TIR) domain found ...
 11-141 7.23e-58

Toll/interleukin-1 receptor domain; This is a Toll/interleukin-1 receptor (TIR) domain found in the N-terminal region of B-cell adaptor for phosphoinositide 3-kinase (BCAP). BCAP functions in linking the B-cell receptor (BCR) and the co-receptor CD19 to the activation of PI3K via interaction with the SH2 domains on the regulatory p85 subunit. BCAP TIR associates with the MAL/TIRAP adaptor and the TIR domains of Toll-like receptors (TLRs).


Pssm-ID: 436583  Cd Length: 128  Bit Score: 193.21  E-value: 7.23e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961509   11 DILIVYSPDAEEWCQYLQTLFLSSrqVRSQKILTHRLGpEASFSAEDLSLFLSTRCVVVLLSAELVQHFHkPALLPLLQR 90
Cdd:pfam18567   1 DILIVYEEEAEEWATYLQSLFVSS--VRELGILLYNLE-DTSLEHLDLLSFKSYKCILLLLSAGLLECLK-PKVLEFLQR 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767961509   91 AFHPPHRVVRLLCGVRDS-EEFLDFFPDWAHWQELTCDDEPETYVAAVKKAI 141
Cdd:pfam18567  77 VLHPPHRVVVLLCGVHESyELLEEFFSDWEIWQEISCDDEPEEYISAVRKII 128
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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