NCBI Conserved Domain Search

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 232.26 E-value: 6.10e-71

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  268 GTVTEFKHPGDFYVQLYSSEVLEYMNQLSASLKETYANVH-EKDYIPVKGEVCIAKYTVDQTWNRAIIQNVDVQQKKAHV 346
Cdd:cd20408     1 GTVTEFKNPGEFYIQIYTLEVLESLVKLTSQLKKTYASVNnHKEYIPEVGEVCVAKYSEDQNWYRALVQTVDVQQKKAGV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 767963288  347 LYIDYGNEEIIPLNRIYHLNRNIDLFPPCAIKCFVANVIPAEGNWSSDCI 396
Cdd:cd20408    81 FYIDYGNEETVPLNRIQPLKKDIELFPPCAIKCCLANVKPPSGSWSEECI 130

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410482 Cd Length: 116 Bit Score: 221.55 E-value: 2.57e-67

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  944 ANVLEIISPNLFYALPKGMPENQEKLCMLTAELLEYCNAPKSRPPYRPRIGDACCAKYTSDDFWYRAVVLGTSDTDVEVL 1023
Cdd:cd20411     1 ALVLEVISPDLFYALPKTGQVNVEKLKALMTELAEYCSKQSVPQQFRPRIGDACCARFTGDKNWYRAVVLETSDSEVKVL 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 767963288 1024 YADYGNIETLPLCRVQPITSSHLALPFQIIRCSLEG 1059
Cdd:cd20411    81 YADYGNTETLPLSRILPITKSHLELPFQIIRCSLAG 116

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410480 Cd Length: 82 Bit Score: 156.46 E-value: 7.12e-45

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  517 GRKLAELQASLSKYCDQLPPRSDFYPAIGDICCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLMRLCPIIPK 596
Cdd:cd20409     1 GRQLAELQESLSAYCKVAPASSDFSPAVGEVCCAQFTEDNQWYRASVLAYSSEDSVLVGYIDFGNSEEVALSRLRPIPPS 80


                  ..
gi 767963288  597 LL 598
Cdd:cd20409    81 LL 82

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 135.94 E-value: 3.25e-37

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288   715 TVDVVVCVIYSPGEFYCHvlKEDALKKLNDLNKSLAEHCQQKLPNGFKAEIGQPCCAFFAGDGSWYRALVKEILPNGHVK 794
Cdd:pfam00567    2 TIDVVVSHIESPSTFYIQ--PKSDSKKLEKLTEELQEYYASKPPESLPPAVGDGCVAAFSEDGKWYRAKITESLDDGLVE 79

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 767963288   795 VHFVDYGNIEEVTADELRMISSTFLNLPFQGIRCQLAD 832
Cdd:pfam00567   80 VLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 124.77 E-value: 2.72e-33

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288   494 DEFCGVVAHIQTPEDFFCQQLQSGRKLAELQASLSKYCdQLPPRSDFYPAIGDICCAQFSEDDQWYRASVLAYASEESVL 573
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYY-ASKPPESLPPAVGDGCVAAFSEDGKWYRAKITESLDDGLVE 79

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 767963288   574 VGYVDYGNFEILSLMRLCPIIPKLLELPMQAIKCVLAG 611
Cdd:pfam00567   80 VLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410481 [Multi-domain] Cd Length: 59 Bit Score: 122.45 E-value: 2.88e-33

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767963288  761 FKAEIGQPCCAFFAGDGSWYRALVKEILPNGHVKVHFVDYGNIEEVTADELRMISSTFL 819
Cdd:cd20410     1 FKPIVGEPCCAFFSGDGNWYRAMVKEILPGGAVKVHFVDYGNVEEVTLDKLRKITSTFL 59

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 119.77 E-value: 1.31e-31

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288   940 KTIQANVLEIISPNLFYALPKgmpENQEKLCMLTAELLEYCNAPKsRPPYRPRIGDACCAKYTSDDFWYRAVVLG-TSDT 1018
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQPK---SDSKKLEKLTEELQEYYASKP-PESLPPAVGDGCVAAFSEDGKWYRAKITEsLDDG 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 767963288  1019 DVEVLYADYGNIETLPLCRVQPITSSHLALPFQIIRCSLEG 1059
Cdd:pfam00567   77 LVEVLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 112.83 E-value: 3.27e-29

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288   264 MEIKGTVTEFKHPGDFYVQlySSEVLEYMNQLSASLKETYANVHEKDYIPVKGEVCIAKYTVDQTWNRAIIQNVDVQQKk 343
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQ--PKSDSKKLEKLTEELQEYYASKPPESLPPAVGDGCVAAFSEDGKWYRAKITESLDDGL- 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 767963288   344 AHVLYIDYGNEEIIPLNRIYHLNRNIDLFPPCAIKCFVAN 383
Cdd:pfam00567   78 VEVLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410482 Cd Length: 116 Bit Score: 110.61 E-value: 1.81e-28

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  519 KLAELQASLSKYCDQLPPRSDFYPAIGDICCAQFSEDDQWYRASVLAyASEESVLVGYVDYGNFEILSLMRLCPIIPKLL 598
Cdd:cd20411    25 KLKALMTELAEYCSKQSVPQQFRPRIGDACCARFTGDKNWYRAVVLE-TSDSEVKVLYADYGNTETLPLSRILPITKSHL 103

                          90
                  ....*....|...
gi 767963288  599 ELPMQAIKCVLAG 611
Cdd:cd20411   104 ELPFQIIRCSLAG 116

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 100.14 E-value: 1.38e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  498 GVVAHIQTPEDFF--CQQLQSGRKLAELQASLSKYCDQLPPRSDFYPAIGDICCAQFSEDDQWYRASVLAY-ASEESVLV 574
Cdd:cd20408     1 GTVTEFKNPGEFYiqIYTLEVLESLVKLTSQLKKTYASVNNHKEYIPEVGEVCVAKYSEDQNWYRALVQTVdVQQKKAGV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 767963288  575 GYVDYGNFEILSLMRLCPIIPKLLELPMQAIKCVLAGVKPSLGIWTPEAI 624
Cdd:cd20408    81 FYIDYGNEETVPLNRIQPLKKDIELFPPCAIKCCLANVKPPSGSWSEECI 130

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410482 Cd Length: 116 Bit Score: 99.06 E-value: 2.20e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  719 VVCVIySPGEFYC-HVLKEDALKKLNDLNKSLAEHCQ-QKLPNGFKAEIGQPCCAFFAGDGSWYRALVKEIlPNGHVKVH 796
Cdd:cd20411     3 VLEVI-SPDLFYAlPKTGQVNVEKLKALMTELAEYCSkQSVPQQFRPRIGDACCARFTGDKNWYRAVVLET-SDSEVKVL 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 767963288  797 FVDYGNIEEVTADELRMISSTFLNLPFQGIRCQLA 831
Cdd:cd20411    81 YADYGNTETLPLSRILPITKSHLELPFQIIRCSLA 115

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 89.35 E-value: 8.20e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  946 VLEIISPNLFYALPKGmPENQEKLCMLTAELLEYCNAPKSRPPYRPRIGDACCAKYTSDDFWYRAVVLGTSDTD--VEVL 1023
Cdd:cd20408     3 VTEFKNPGEFYIQIYT-LEVLESLVKLTSQLKKTYASVNNHKEYIPEVGEVCVAKYSEDQNWYRALVQTVDVQQkkAGVF 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 767963288 1024 YADYGNIETLPLCRVQPITSSHLALPFQIIRCSLEGLMELNGS 1066
Cdd:cd20408    82 YIDYGNEETVPLNRIQPLKKDIELFPPCAIKCCLANVKPPSGS 124

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 88.20 E-value: 2.45e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  718 VVVCVIYSPGEFYCHVLKEDALKKLNDLNKSLAEHCQQ-KLPNGFKAEIGQPCCAFFAGDGSWYRALVKEILPNGH-VKV 795
Cdd:cd20408     1 GTVTEFKNPGEFYIQIYTLEVLESLVKLTSQLKKTYASvNNHKEYIPEVGEVCVAKYSEDQNWYRALVQTVDVQQKkAGV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 767963288  796 HFVDYGNIEEVTADELRMISSTFLNLPFQGIRCQLADIQSRNKHWSEEAI 845
Cdd:cd20408    81 FYIDYGNEETVPLNRIQPLKKDIELFPPCAIKCCLANVKPPSGSWSEECI 130

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410508 Cd Length: 120 Bit Score: 87.09 E-value: 3.55e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  712 VDQTVDVVVCVIYSPGEFYCHVLKEDalKKLNDLNKSLAEHCQQKlpNGFKAEIGQPC---CAFFAGDGSWYRALVKEIL 788
Cdd:cd20437     1 VGTTEKVKITAAVSPSKFYCQLLSWE--PELSKLTTQMTLHYESV--SKELNPSCENFgllCAAKGKDGQWHRGFLQQLL 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 767963288  789 PNGHVKVHFVDYGNIEEVTADELRMISSTFLNLPFQGIRCQLAD 832
Cdd:cd20437    77 PPSQVKVWFIDYGNSEAVSSHSVLKLPPDFFSLPLMSFPCSLSC 120

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410480 Cd Length: 82 Bit Score: 85.20 E-value: 5.35e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  967 EKLCMLTAELLEYCNAPKSRPPYRPRIGDACCAKYTSDDFWYRAVVLG-TSDTDVEVLYADYGNIETLPLCRVQPITSSH 1045
Cdd:cd20409     2 RQLAELQESLSAYCKVAPASSDFSPAVGEVCCAQFTEDNQWYRASVLAySSEDSVLVGYIDFGNSEEVALSRLRPIPPSL 81


                  .
gi 767963288 1046 L 1046
Cdd:cd20409    82 L 82

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410510 Cd Length: 125 Bit Score: 82.92 E-value: 1.29e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  486 KVLTLNVGDEFCGVVAHIQTPEDFFCQqLQSgrKLAELQASLSKYCDQLPPRSDFYPAIGDICCAQFSEDDQWYRASVLA 565
Cdd:cd20439     2 KEYLFKPGSVVDVKCSYVNSPGDFWCQ-LQT--KSSELKSLMKQIQSYYLIHNDPYKHGQIACVAKYSKDGKWYRAAVLK 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 767963288  566 YASEESVLVGYVDYGNFEILSLMRLCPIIPKLLELPMQAIKCVLAGV 612
Cdd:cd20439    79 QVSAKEVDVIFVDYGNQERVLISDLRAIKPQFLLLEGQAFRCSLNNF 125

Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410514 [Multi-domain] Cd Length: 117 Bit Score: 82.13 E-value: 2.05e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  509 FFCQQLQSGRkLAELQASLSKYC--DQLPPRSDFYPAIGDICCAQFSEDDQWYRASVL------AYASEESVLVGYVDYG 580
Cdd:cd20443     4 FYVQVVSDQR-LSSIQQQLEGLSlkDKANPPGGFNPKKGELVLAQFSADNSWNRAMVVnaprqgTQSPKDEYEVFYIDYG 82

                          90       100       110
                  ....*....|....*....|....*....|....
gi 767963288  581 NFEILSLMRLCPIIPKLLELPMQAIKCVLAGVKP 614
Cdd:cd20443    83 NQETVPLSALRPLDPSVSSAPGLAQLCSLAHIKV 116

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410511 Cd Length: 127 Bit Score: 81.35 E-value: 4.71e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  718 VVVCVIYSPGEFYCHVLKEDALkkLNDLNKSLAEhcQQKLPNGFKAEIGQP--CCAFFAGDGSWYRALVKEILPNGHVKV 795
Cdd:cd20440    14 VYITHVYSPAKFYCQLDRNTEI--LEALMEKIAE--ISKLFNSQILDNCKTrlCLAKYFEDGQWYRALAHPVESSSHLSV 89

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 767963288  796 HFVDYGNIEEVTADELRMISSTFLNL---PFQGIRCQL 830
Cdd:cd20440    90 YFVDYGNKQIVEKNEVLPIPDTAVDLlltPMQAIKCCL 127

Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410514 [Multi-domain] Cd Length: 117 Bit Score: 80.59 E-value: 7.45e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  277 GDFYVQLYSSEVLE-YMNQLSA-SLKETyANVhEKDYIPVKGEVCIAKYTVDQTWNRAIIQNVDVQ-----QKKAHVLYI 349
Cdd:cd20443     2 GRFYVQVVSDQRLSsIQQQLEGlSLKDK-ANP-PGGFNPKKGELVLAQFSADNSWNRAMVVNAPRQgtqspKDEYEVFYI 79

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 767963288  350 DYGNEEIIPLNRIYHLNRNIDLFPPCAIKCFVANVIP 386
Cdd:cd20443    80 DYGNQETVPLSALRPLDPSVSSAPGLAQLCSLAHIKV 116

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410497 Cd Length: 140 Bit Score: 79.85 E-value: 2.21e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  720 VCVIYSPGEFYCHVlkedALKKLNDLNKSLAEHCQQKLPNGFKA---EIGQPCCAFFAGDGSWYRALVKEILPNgHVKVH 796
Cdd:cd20426     5 ATAVDSPEYFWCQF----ATEKIQCLAVKVQEAGEQVADRGNFIpsiYVGDPCIVKYSEDNHWYRALVTKINDN-LVSVR 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767963288  797 FVDYGNIEEVTADELRMISSTFLNLPFQGIRCQLADIQSRNKHWSEEAITRF 848
Cdd:cd20426    80 FVDYGNEEDVVREQVRALPSELLKIPVQAFPCCLSGFNLSEGLWSDEANDYF 131

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 77.34 E-value: 3.34e-17

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767963288  292 MNQLSaslKETYAN-VHEKDYIPVKGEVCIAKYTVDQTWNRAIIQNVDvQQKKAHVLYIDYGNEEIIPLNRI 362
Cdd:cd20433     9 MEKLR---FEIASNpPLPGSYTPRKGDLCAAKFVEDGEWYRAKVEKVE-GDKKVHVLYIDYGNREVLPSTRL 76

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410483 Cd Length: 95 Bit Score: 77.72 E-value: 4.37e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  740 KKLNDLNKSLAEHCQQK--LPNGFKAEIGQPCCAFFAGDGSWYRALVKEILPNGHVKVHFVDYGNIEEVTADELRMISST 817
Cdd:cd20412     4 LQLDKLVQEMTQYYESEenRHTLLTVQVGDIVAAPFRHDGSWYRARVLGFLENGNLDLYFVDYGDSGYVPLEDLRALRSD 83

                          90
                  ....*....|.
gi 767963288  818 FLNLPFQGIRC 828
Cdd:cd20412    84 FLSLPFQAIEC 94

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 76.18 E-value: 8.93e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  516 SGRKLAELQASLSKYCDQLPP-RSDFYPAIGDICCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLMRLCPII 594
Cdd:cd20433     1 TGPQLEKLMEKLRFEIASNPPlPGSYTPRKGDLCAAKFVEDGEWYRAKVEKVEGDKKVHVLYIDYGNREVLPSTRLAALP 80


                  .
gi 767963288  595 P 595
Cdd:cd20433    81 P 81

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 74.09 E-value: 2.22e-16

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 767963288  765 IGQPCCAFFAGDGSWYRALVKEILPNGHVKVHFVDYGNIEEVTADELRMI 814
Cdd:cd20379     1 VGDLCAAKYEEDGKWYRARVLEVLSNDKVEVFFVDYGNTETVPLSDLRPL 50

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410497 Cd Length: 140 Bit Score: 76.00 E-value: 4.62e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  498 GVVAHIQTPEDFFCQQLQSG-RKLAELQASLSKYCDQlppRSDFYPAI--GDICCAQFSEDDQWYRASVLAYASEEsVLV 574
Cdd:cd20426     3 AYATAVDSPEYFWCQFATEKiQCLAVKVQEAGEQVAD---RGNFIPSIyvGDPCIVKYSEDNHWYRALVTKINDNL-VSV 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 767963288  575 GYVDYGNFEILSLMRLCPIIPKLLELPMQAIKCVLAGVKPSLGIWTPEA 623
Cdd:cd20426    79 RFVDYGNEEDVVREQVRALPSELLKIPVQAFPCCLSGFNLSEGLWSDEA 127

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410493 Cd Length: 135 Bit Score: 74.85 E-value: 1.06e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  717 DVVVCVIYSPGEFYCHvLKEDALKkLNDLNKSLAEHCQQ--KLpNGF--KAEIGQPCCAFFAGDGsWYRALVKEILPNGh 792
Cdd:cd20422     3 DAQVEFVKDPSEFWIR-LGEHAVP-FSKLMRSMTAFYSQasKL-DGVvlKPQPGQLCCAKWKEDR-YYRAIVTAVKGKM- 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767963288  793 VKVHFVDYGNIEEVTADELRMISSTFLNLPFQGIRCQLADIQSRNKHWSEEAITRFQ 849
Cdd:cd20422    78 VEVFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCLADICPLGERWSPEAISAFK 134

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410510 Cd Length: 125 Bit Score: 73.68 E-value: 2.40e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  715 TVDVVVCVIYSPGEFYCHVLKedalkKLNDLnKSLAEHCQQK-LPNGFKAEIGQ-PCCAFFAGDGSWYRALVKEILPNGH 792
Cdd:cd20439    11 VVDVKCSYVNSPGDFWCQLQT-----KSSEL-KSLMKQIQSYyLIHNDPYKHGQiACVAKYSKDGKWYRAAVLKQVSAKE 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 767963288  793 VKVHFVDYGNIEEVTADELRMISSTFLNLPFQGIRCQLADI 833
Cdd:cd20439    85 VDVIFVDYGNQERVLISDLRAIKPQFLLLEGQAFRCSLNNF 125

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 71.18 E-value: 5.89e-15

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767963288  983 PKSRPPYRPRIGDACCAKYTSDDFWYRA-VVLGTSDTDVEVLYADYGNIETLPLCRVQPITSS 1044
Cdd:cd20433    20 PPLPGSYTPRKGDLCAAKFVEDGEWYRAkVEKVEGDKKVHVLYIDYGNREVLPSTRLAALPPA 82

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410481 [Multi-domain] Cd Length: 59 Bit Score: 70.06 E-value: 7.69e-15

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767963288  540 FYPAIGDICCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLMRLCPIIPKLL 598
Cdd:cd20410     1 FKPIVGEPCCAFFSGDGNWYRAMVKEILPGGAVKVHFVDYGNVEEVTLDKLRKITSTFL 59

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410497 Cd Length: 140 Bit Score: 72.53 E-value: 8.01e-15

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767963288  991 PRIGDACCAKYTSDDFWYRAVVLGTSDTDVEVLYADYGNIETLPLCRVQPITSSHLALPFQIIRCSLEGLMELNGSSSQ 1069
Cdd:cd20426    47 IYVGDPCIVKYSEDNHWYRALVTKINDNLVSVRFVDYGNEEDVVREQVRALPSELLKIPVQAFPCCLSGFNLSEGLWSD 125

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410494 Cd Length: 80 Bit Score: 70.20 E-value: 1.00e-14

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767963288  547 ICCAQFSEDDQWYRASVL-AYASEESVLVGYVDYGNFEILSLMRLCPIIPKLLELPMQAIKCVLAGVKPSLG 617
Cdd:cd20423     8 VCLAKYSEDGKWCRALIDnVYEPVEMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSLYNLIQPSG 79

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410493 Cd Length: 135 Bit Score: 72.16 E-value: 1.03e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  496 FC-GVVAHIQTPEDFFCQQLQSGRKLAELQASLSkycdqlpprsDFY------------PAIGDICCAQFsEDDQWYRAS 562
Cdd:cd20422     1 FYdAQVEFVKDPSEFWIRLGEHAVPFSKLMRSMT----------AFYsqaskldgvvlkPQPGQLCCAKW-KEDRYYRAI 69

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767963288  563 VLAyASEESVLVGYVDYGNFEILSLMRLCPIIPKLLELPMQAIKCVLAGVKPSLGIWTPEAICLMKK 629
Cdd:cd20422    70 VTA-VKGKMVEVFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCLADICPLGERWSPEAISAFKR 135

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410494 Cd Length: 80 Bit Score: 70.20 E-value: 1.20e-14

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767963288  318 VCIAKYTVDQTWNRAIIQNVDVQQKKAHVLYIDYGNEEIIPLNRIYHLNRNIDLFPPCAIKCFVANVIPAEGN 390
Cdd:cd20423     8 VCLAKYSEDGKWCRALIDNVYEPVEMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSLYNLIQPSGQ 80

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410496 Cd Length: 115 Bit Score: 70.56 E-value: 2.06e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  716 VDVVVCVIYSPGEFYCHVLKEDAlkKLNDLNKSLAEHCQQKLPNGFKA-EIGQPCCAFFAGDGSWYRALVKEILPNGHVK 794
Cdd:cd20425     2 TEVYVSHVNSPSDFYVQLAQDED--ELSMISEKLNASKANDEEVECESlQLGDLICAEYPEDGLWYRAVVKEKIPNNLVS 79

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 767963288  795 VHFVDYGNIEEVTADELRMISSTFLNLPFQGIRCQL 830
Cdd:cd20425    80 VQFIDYGNTSVVQPSKIHRLPKELLSIPALSIHCFL 115

Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410514 [Multi-domain] Cd Length: 117 Bit Score: 70.19 E-value: 2.73e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  968 KLCMLTAELLEYCNAPKSRPP--YRPRIGDACCAKYTSDDFWYRAVVLG-------TSDTDVEVLYADYGNIETLPLCRV 1038
Cdd:cd20443    13 RLSSIQQQLEGLSLKDKANPPggFNPKKGELVLAQFSADNSWNRAMVVNaprqgtqSPKDEYEVFYIDYGNQETVPLSAL 92

                          90       100
                  ....*....|....*....|..
gi 767963288 1039 QPITSSHLALPFQIIRCSLEGL 1060
Cdd:cd20443    93 RPLDPSVSSAPGLAQLCSLAHI 114

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410512 Cd Length: 108 Bit Score: 69.38 E-value: 4.31e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  725 SPGEFYCHVLK-EDALKKLNDLNKSLAEHCQQKLPNgfKAEIGQPCCAFFAGDGSWYRALVKEILPNGHVKVHFVDYGNI 803
Cdd:cd20441     1 SPSRFFIQLSEdEKVILQLAEELNETSEKSRENAAV--KLKVGDLVAAEYDEDLALYRAVITAVLPGKSFKVEFIDYGNT 78

                          90       100       110
                  ....*....|....*....|....*....|
gi 767963288  804 EEVTADELRMISSTFLNLPFQGIRCQLADI 833
Cdd:cd20441    79 AVVDKSNIYTLQEKFLSLPRLSIPCSLSGV 108

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410489 Cd Length: 105 Bit Score: 68.97 E-value: 6.63e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  538 SDFYPaiGDICCAQFSeDDQWYRASVLAYASEESV--LVGYVDYGNFEILSLMRLCPIIPKLLELPMQAIKCVLAGVKPS 615
Cdd:cd20418     2 TDFRP--EMPCLAEYS-DGKWYRAKLLSILEFNPVkiLVRHVDYGSTAALPTSRLRQIPAELMQYPCQAIKVKLAGFKPP 78


                  .
gi 767963288  616 L 616
Cdd:cd20418    79 L 79

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 66.38 E-value: 9.21e-14

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 767963288  544 IGDICCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLMRLCPI 593
Cdd:cd20379     1 VGDLCAAKYEEDGKWYRARVLEVLSNDKVEVFFVDYGNTETVPLSDLRPL 50

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410490 Cd Length: 118 Bit Score: 68.24 E-value: 1.39e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  720 VCVIYSPGEFYCHVLKEDALKKLNDLNKSL-----AEHCQQK--LPNGFKAEiGQPCCAFFAGDGSWYRALVKEILPNGH 792
Cdd:cd20419     2 VEYIESPSQFYVRFYSKDTSEMLEDMMIEMrrcysNEHVSERyvMPEAFIQP-GQVCCVRIPEDVWWYRVIIHQVLNKQE 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 767963288  793 VKVHFVDYGNIEEVTADELRMISSTFLNLPFQGIRCQL 830
Cdd:cd20419    81 VEVFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPASL 118

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 64.84 E-value: 3.68e-13

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767963288  315 KGEVCIAKYTVDQTWNRAIIQNVDvQQKKAHVLYIDYGNEEIIPLNRIYHL 365
Cdd:cd20379     1 VGDLCAAKYEEDGKWYRARVLEVL-SNDKVEVFFVDYGNTETVPLSDLRPL 50

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410511 Cd Length: 127 Bit Score: 67.10 E-value: 4.25e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  500 VAHIQTPEDFFCQQlqsGRKLAELQASLSKYCD--QLPPRSDFYPAIGDICCAQFSEDDQWYRASVLAYASEESVLVGYV 577
Cdd:cd20440    16 ITHVYSPAKFYCQL---DRNTEILEALMEKIAEisKLFNSQILDNCKTRLCLAKYFEDGQWYRALAHPVESSSHLSVYFV 92

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 767963288  578 DYGNFEILSLMRLCPI---IPKLLELPMQAIKCVL 609
Cdd:cd20440    93 DYGNKQIVEKNEVLPIpdtAVDLLLTPMQAIKCCL 127

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410483 Cd Length: 95 Bit Score: 66.16 E-value: 4.37e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  968 KLCMLTAELLEYCNAPKSRPPYR-PRIGDACCAKYTSDDFWYRAVVLGTSDTD-VEVLYADYGNIETLPLCRVQPITSSH 1045
Cdd:cd20412     5 QLDKLVQEMTQYYESEENRHTLLtVQVGDIVAAPFRHDGSWYRARVLGFLENGnLDLYFVDYGDSGYVPLEDLRALRSDF 84

                          90
                  ....*....|.
gi 767963288 1046 LALPFQIIRCS 1056
Cdd:cd20412    85 LSLPFQAIECS 95

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 65.40 E-value: 5.48e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  737 DALKKL-NDLNKSLAEHcqQKLPNGFKAEIGQPCCAFFAGDGSWYRALVKEILPNGHVKVHFVDYGNIEEVTADELRMIS 815
Cdd:cd20433     3 PQLEKLmEKLRFEIASN--PPLPGSYTPRKGDLCAAKFVEDGEWYRAKVEKVEGDKKVHVLYIDYGNREVLPSTRLAALP 80


                  ...
gi 767963288  816 STF 818
Cdd:cd20433    81 PAF 83

Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope, where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. It contains a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410478 Cd Length: 76 Bit Score: 64.92 E-value: 7.77e-13

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767963288  764 EIGQPCCAFFAGdgSWYRALVKEILPN-GHVKVHFVDYGNIEEVTADELRMISSTFLNLPFQGIRCQLADIQ 834
Cdd:cd20407     6 EVGVICAAPVMN--AWYRAQVVGVFEEtDEVEIKYLDYGGYERVPVDDLRQIRSDFMTLPFQATECYLANIE 75

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410483 Cd Length: 95 Bit Score: 65.01 E-value: 1.17e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  519 KLAELQASLSKYCDQLPPRSDF-YPAIGDICCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLMRLCPIIPKL 597
Cdd:cd20412     5 QLDKLVQEMTQYYESEENRHTLlTVQVGDIVAAPFRHDGSWYRARVLGFLENGNLDLYFVDYGDSGYVPLEDLRALRSDF 84

                          90
                  ....*....|
gi 767963288  598 LELPMQAIKC 607
Cdd:cd20412    85 LSLPFQAIEC 94

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410486 Cd Length: 96 Bit Score: 64.76 E-value: 1.63e-12

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  766 GQPCCAFFAgDGSWYRALVKEILPNGHVKVHFVDYGNIEEVTADELRMISSTFLNLPFQGIRCQLADIQS 835
Cdd:cd20415    28 GQACVALFE-DGAWYRARIIGLPGHREVEVKYVDFGNTATVTIKHVRKIKDDFLSLPEKARECRLAFIEP 96

MYND finger;

Pssm-ID: 460312 Cd Length: 39 Bit Score: 62.82 E-value: 1.73e-12

                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 767963288   170 CHRCGLFGS--LRCSQCKQTYYCSTACQRRDWSAHSIVC 206
Cdd:pfam01753    1 CAVCGKEALklLRCSRCKSVYYCSKECQKADWPYHKKEC 39

Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, also called serine/threonine-protein kinase (EC 2.7.11.1) 31 (STK31), serine/threonine-protein kinase NYD-SPK, or Sugen kinase 396 (SgK396), is a germ cell-specific factor expressed in embryonic gonocytes of both sexes, and in postnatal spermatocytes and round spermatids in males. It acts as a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells. TDRD8 contains a Tudor domain and a serine/threonine kinase domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410501 [Multi-domain] Cd Length: 75 Bit Score: 63.85 E-value: 1.77e-12

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767963288  526 SLSKYCDQLPPRSDfYPAIGDICCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLMRLCPIIPKL 597
Cdd:cd20430     4 ELAEVCPTAPPLFG-TPDPNKIYGGKFSEDNCWYRCKVKSILSDEKCTVQYIDYGNTETVSRSSIVELPPDL 74

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410495 Cd Length: 126 Bit Score: 65.22 E-value: 2.45e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  490 LNVGDEFCGVVAHIQTPEDFFCQQLQSGRKLAELQASLSKYCDQLPP-RSDFYPaiGDICCAQFSeDDQWYRASVLAyaS 568
Cdd:cd20424     8 IKIGSEEEVYITYVNDPWTFYCQLARNAGVLDQLASAISRLSSEIRKlELSVNP--GTLCLAKYS-DQHWYRGIIIT--N 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 767963288  569 EESVLVGYVDYGNFEILSLMRLCPI---IPKLLELPMQAIKCVL 609
Cdd:cd20424    83 KNSTEVFFVDYGNTEKVEKEDMLPIpsdAYELLLLPMQAIKCSL 126

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410494 Cd Length: 80 Bit Score: 63.65 E-value: 2.55e-12

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767963288  768 PCCAFFAGDGSWYRALVKEI-LPNGHVKVHFVDYGNIEEVTADELRMISSTFLNLPFQGIRCQLADIQ 834
Cdd:cd20423     8 VCLAKYSEDGKWCRALIDNVyEPVEMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSLYNLI 75

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410480 Cd Length: 82 Bit Score: 63.63 E-value: 2.67e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  741 KLNDLNKSLAEHCQQKLPN-GFKAEIGQPCCAFFAGDGSWYRALVKEILPNGHVKVHFVDYGNIEEVTADELRMISSTFL 819
Cdd:cd20409     3 QLAELQESLSAYCKVAPASsDFSPAVGEVCCAQFTEDNQWYRASVLAYSSEDSVLVGYIDFGNSEEVALSRLRPIPPSLL 82

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 62.15 E-value: 3.10e-12

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 767963288  993 IGDACCAKYTSDDFWYRAVVLGTSDTD-VEVLYADYGNIETLPLCRVQPI 1041
Cdd:cd20379     1 VGDLCAAKYEEDGKWYRARVLEVLSNDkVEVFFVDYGNTETVPLSDLRPL 50

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410481 [Multi-domain] Cd Length: 59 Bit Score: 61.97 E-value: 4.56e-12

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767963288  989 YRPRIGDACCAKYTSDDFWYRAVVLG-TSDTDVEVLYADYGNIETLPLCRVQPITSSHL 1046
Cdd:cd20410     1 FKPIVGEPCCAFFSGDGNWYRAMVKEiLPGGAVKVHFVDYGNVEEVTLDKLRKITSTFL 59

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410482 Cd Length: 116 Bit Score: 64.00 E-value: 5.10e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  270 VTEFKHPGDFY-VQLYSSEVLEYMNQLSASLKEtYANVHE--KDYIPVKGEVCIAKYTVDQTWNRAIIqnVDVQQKKAHV 346
Cdd:cd20411     3 VLEVISPDLFYaLPKTGQVNVEKLKALMTELAE-YCSKQSvpQQFRPRIGDACCARFTGDKNWYRAVV--LETSDSEVKV 79

                          90       100       110
                  ....*....|....*....|....*....|...
gi 767963288  347 LYIDYGNEEIIPLNRIYHLNRNIDLFPPCAIKC 379
Cdd:cd20411    80 LYADYGNTETLPLSRILPITKSHLELPFQIIRC 112

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410494 Cd Length: 80 Bit Score: 62.50 E-value: 5.36e-12

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767963288  996 ACCAKYTSDDFWYRAVVLGTSDT--DVEVLYADYGNIETLPLCRVQPITSSHLALPFQIIRCSLEGLMELNG 1065
Cdd:cd20423     8 VCLAKYSEDGKWCRALIDNVYEPveMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSLYNLIQPSG 79

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410495 Cd Length: 126 Bit Score: 64.06 E-value: 6.10e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  717 DVVVCVIYSPGEFYCHVLKEDALkkLNDLNKSLAEHCQQKLPNGFKAEIGQPCCAFFAgDGSWYRALVKEILPNghVKVH 796
Cdd:cd20424    15 EVYITYVNDPWTFYCQLARNAGV--LDQLASAISRLSSEIRKLELSVNPGTLCLAKYS-DQHWYRGIIITNKNS--TEVF 89

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 767963288  797 FVDYGNIEEVTADELRMISS---TFLNLPFQGIRCQL 830
Cdd:cd20424    90 FVDYGNTEKVEKEDMLPIPSdayELLLLPMQAIKCSL 126

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410498 Cd Length: 98 Bit Score: 62.83 E-value: 6.42e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  539 DFYPAIGDICCAQF----------SEDDQWYRASVLAyASEESVLVGYVDYGNFEILSLMRLCPIIPKLLELPMQAIKCV 608
Cdd:cd20427     9 EFYSKSSTAMCLRSpsvgqlvavkAEEDAWLRAQVIE-VEEDKVKVYYVDHGFSEVVERSKLFKLNKQFYSLPFQATKCK 87


                  ....*.
gi 767963288  609 LAGVKP 614
Cdd:cd20427    88 LAGLEP 93

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410509 Cd Length: 141 Bit Score: 64.42 E-value: 6.78e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  498 GVVAHIQTPEDFFCQQLQSGRKLAELQASLSKYCDQLPPRSDFY--PAIGDICCAQFSEDDQWYRAsVLAYASEESVLVG 575
Cdd:cd20438     9 AFVEYVLNPSNFWIRTDEYNNEFQALMKNIADIYNLCGNDEELLkkPEPGLLCCARYSKDRHYYRA-VITEVLDLKVSVY 87

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767963288  576 YVDYGNFEILSLMRLCPIIPKLLELPMQAIKCVLAGVKPSLGIWTPEAICLMKK 629
Cdd:cd20438    88 FLDFGNTDTVPFYDVKTLLPEFSELPALAMCCSLAHVFPVEEVWTKNANDFFKK 141

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410490 Cd Length: 118 Bit Score: 63.24 E-value: 8.30e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  946 VLEIISPNLFYALPKGmPENQEKLCMLTAELLEYCNAPKSRPPYRP-----RIGDACCAKYTSDDFWYRAVVLGT-SDTD 1019
Cdd:cd20419     2 VEYIESPSQFYVRFYS-KDTSEMLEDMMIEMRRCYSNEHVSERYVMpeafiQPGQVCCVRIPEDVWWYRVIIHQVlNKQE 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 767963288 1020 VEVLYADYGNIETLPLCRVQPITSSHLALPFQIIRCSL 1057
Cdd:cd20419    81 VEVFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPASL 118

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410492 Cd Length: 130 Bit Score: 63.21 E-value: 1.21e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  709 ELGVDQTVDVVVCVIYSPGEFYCHvlkedaLKKLNDLNKSLAEHCQQ------KLPNGFKAEI-GQPCCAFfAGDGSWYR 781
Cdd:cd20421     6 QLQVGVTETVVVTEVTDPHRIFCQ------LRSLSQELKRLSESMHQyyegrvGSGYETRPEKlGSPCAAR-GSDGRWYR 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 767963288  782 ALVKEILPNGH-VKVHFVDYGNIEEVTADELRMISSTFLNLPFQGIRCQL 830
Cdd:cd20421    79 AVLQQVFSANRvVEVLHVDYGRKEVVSVSNLRYLAPEYFRMPVVTYPCAL 128

Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope, where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. It contains a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410478 Cd Length: 76 Bit Score: 61.07 E-value: 1.73e-11

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767963288  544 IGDICCAQFseDDQWYRASVLAYASE-ESVLVGYVDYGNFEILSLMRLCPIIPKLLELPMQAIKCVLAGVKP 614
Cdd:cd20407     7 VGVICAAPV--MNAWYRAQVVGVFEEtDEVEIKYLDYGGYERVPVDDLRQIRSDFMTLPFQATECYLANIEP 76

second Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410499 Cd Length: 140 Bit Score: 62.85 E-value: 1.92e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  717 DVVVCVIYSPGEFYCHVLKEdALKKLND-LNKSLAE-HCQQKLPNGFkaeIGQPCCA---FFAGDGSWYRALVKEILPNG 791
Cdd:cd20428     3 NVRVTNVCSDGTLYCQVPSK-GLSKLNEiLDKIEYYfHSRQMTSEYF---VSLPFCGkicLARYKGKWARVEITNVHSSR 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767963288  792 HVKVHFVDYGNIEEVTADELRMISSTFL----NLPFQGIRCQLADIQSRNKHWSEEAIT 846
Cdd:cd20428    79 ALDVHFLDTGTVASVKVSELREIPPPFLreliSIPPQALKCCLADLPLNIGMWTPDAVL 137

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410496 Cd Length: 115 Bit Score: 61.32 E-value: 3.24e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  500 VAHIQTPEDFFCQQLQSGRKLAELQASLSKYCDQLPPRSDFYPAIGDICCAQFSEDDQWYRASVLAYASEESVLVGYVDY 579
Cdd:cd20425     6 VSHVNSPSDFYVQLAQDEDELSMISEKLNASKANDEEVECESLQLGDLICAEYPEDGLWYRAVVKEKIPNNLVSVQFIDY 85

                          90       100       110
                  ....*....|....*....|....*....|
gi 767963288  580 GNFEILSLMRLCPIIPKLLELPMQAIKCVL 609
Cdd:cd20425    86 GNTSVVQPSKIHRLPKELLSIPALSIHCFL 115

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410486 Cd Length: 96 Bit Score: 60.91 E-value: 3.40e-11

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767963288  542 PAIGDICCAQFsEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLMRLCPIIPKLLELPMQAIKCVLAGVKP 614
Cdd:cd20415    25 PVQGQACVALF-EDGAWYRARIIGLPGHREVEVKYVDFGNTATVTIKHVRKIKDDFLSLPEKARECRLAFIEP 96

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

Pssm-ID: 197660 Cd Length: 57 Bit Score: 58.44 E-value: 7.50e-11

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 767963288    766 GQPCCAFFaGDGSWYRALVKEILPNGHVKVHFVDYGNIEEVTADELR 812
Cdd:smart00333    6 GDKVAARW-EDGEWYRARIVKVDGEQLYEVFFIDYGNEEVVPPSDLR 51

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410486 Cd Length: 96 Bit Score: 59.76 E-value: 8.74e-11

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  989 YRPRIGDACCAKYtSDDFWYRAVVLG-TSDTDVEVLYADYGNIETLPLCRVQPITSSHLALPFQIIRCSL 1057
Cdd:cd20415    23 LCPVQGQACVALF-EDGAWYRARIIGlPGHREVEVKYVDFGNTATVTIKHVRKIKDDFLSLPEKARECRL 91

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410512 Cd Length: 108 Bit Score: 58.98 E-value: 1.90e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  506 PEDFFCQQLQSGRKLAELQASLSKYCDQLPPRSDFYPAIGDICCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEIL 585
Cdd:cd20441     2 PSRFFIQLSEDEKVILQLAEELNETSEKSRENAAVKLKVGDLVAAEYDEDLALYRAVITAVLPGKSFKVEFIDYGNTAVV 81

                          90       100
                  ....*....|....*....|....*..
gi 767963288  586 SLMRLCPIIPKLLELPMQAIKCVLAGV 612
Cdd:cd20441    82 DKSNIYTLQEKFLSLPRLSIPCSLSGV 108

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410490 Cd Length: 118 Bit Score: 59.38 E-value: 2.08e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  500 VAHIQTPEDF---FCQQLQSgRKLAELQASLsKYCDQLPPRSDFYPAI------GDICCAQFSEDDQWYRASVLAYASEE 570
Cdd:cd20419     2 VEYIESPSQFyvrFYSKDTS-EMLEDMMIEM-RRCYSNEHVSERYVMPeafiqpGQVCCVRIPEDVWWYRVIIHQVLNKQ 79

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 767963288  571 SVLVGYVDYGNFEILSLMRLCPIIPKLLELPMQAIKCVL 609
Cdd:cd20419    80 EVEVFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPASL 118

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410510 Cd Length: 125 Bit Score: 59.04 E-value: 3.29e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  949 IISPNLFYAlpkGMPENQEKLCMLTAELLEYCNApkSRPPYRPriGD-ACCAKYTSDDFWYRAVVLG-TSDTDVEVLYAD 1026
Cdd:cd20439    19 VNSPGDFWC---QLQTKSSELKSLMKQIQSYYLI--HNDPYKH--GQiACVAKYSKDGKWYRAAVLKqVSAKEVDVIFVD 91

                          90       100       110
                  ....*....|....*....|....*....|....
gi 767963288 1027 YGNIETLPLCRVQPITSSHLALPFQIIRCSLEGL 1060
Cdd:cd20439    92 YGNQERVLISDLRAIKPQFLLLEGQAFRCSLNNF 125

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410509 Cd Length: 141 Bit Score: 58.64 E-value: 6.33e-10

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767963288  990 RPRIGDACCAKYTSDDFWYRAVVLGTSDTDVEVLYADYGNIETLPLCRVQPITSSHLALPFQIIRCSL 1057
Cdd:cd20438    54 KPEPGLLCCARYSKDRHYYRAVITEVLDLKVSVYFLDFGNTDTVPFYDVKTLLPEFSELPALAMCCSL 121

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410508 Cd Length: 120 Bit Score: 57.43 E-value: 8.61e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  497 CGVVAHIQ-----TPEDFFCQQLQSGRKLAELQASLSKYCD-----QLPPRSDFypaigDICCAQFSEDDQWYRASVLAY 566
Cdd:cd20437     1 VGTTEKVKitaavSPSKFYCQLLSWEPELSKLTTQMTLHYEsvskeLNPSCENF-----GLLCAAKGKDGQWHRGFLQQL 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 767963288  567 ASEESVLVGYVDYGNFEILSLMRLCPIIPKLLELPMQAIKCVLA 610
Cdd:cd20437    76 LPPSQVKVWFIDYGNSEAVSSHSVLKLPPDFFSLPLMSFPCSLS 119

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

Pssm-ID: 197660 Cd Length: 57 Bit Score: 54.97 E-value: 1.32e-09

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 767963288    311 YIPVKGEVCIAKYTvDQTWNRAIIQNVDvQQKKAHVLYIDYGNEEIIPLNRIYHLNR 367
Cdd:smart00333    1 PTFKVGDKVAARWE-DGEWYRARIVKVD-GEQLYEVFFIDYGNEEVVPPSDLRQLPE 55

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410510 Cd Length: 125 Bit Score: 57.12 E-value: 1.34e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  268 GTVTEFK-----HPGDFYVQLY--SSEVLEYMNQLsaslkETYANVHEKDYIPvkGEV-CIAKYTVDQTWNRAIIQNVdV 339
Cdd:cd20439     9 GSVVDVKcsyvnSPGDFWCQLQtkSSELKSLMKQI-----QSYYLIHNDPYKH--GQIaCVAKYSKDGKWYRAAVLKQ-V 80

                          90
                  ....*....|....*.
gi 767963288  340 QQKKAHVLYIDYGNEE 355
Cdd:cd20439    81 SAKEVDVIFVDYGNQE 96

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410493 Cd Length: 135 Bit Score: 57.14 E-value: 1.68e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  267 KGTVTEFKHPGDFYVQLYSSEVleYMNQLSASLKETYANVHEKDYI---PVKGEVCIAKYTvDQTWNRAIIqnVDVQQKK 343
Cdd:cd20422     3 DAQVEFVKDPSEFWIRLGEHAV--PFSKLMRSMTAFYSQASKLDGVvlkPQPGQLCCAKWK-EDRYYRAIV--TAVKGKM 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 767963288  344 AHVLYIDYGNEEIIPLNRIYHLNRNIDLFPPCAIKCFVANVIPAEGNWSSDCIKATK 400
Cdd:cd20422    78 VEVFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCLADICPLGERWSPEAISAFK 134

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410509 Cd Length: 141 Bit Score: 57.48 E-value: 1.81e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  762 KAEIGQPCCAFFAGDGSWYRALVKEILpNGHVKVHFVDYGNIEEVTADELRMISSTFLNLPFQGIRCQLADIQSRNKHWS 841
Cdd:cd20438    54 KPEPGLLCCARYSKDRHYYRAVITEVL-DLKVSVYFLDFGNTDTVPFYDVKTLLPEFSELPALAMCCSLAHVFPVEEVWT 132


                  ....*...
gi 767963288  842 EEAITRFQ 849
Cdd:cd20438   133 KNANDFFK 140

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410512 Cd Length: 108 Bit Score: 55.90 E-value: 2.78e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  276 PGDFYVQLysSEVLEYMNQLSASLKETYANVHEKDYI-PVKGEVCIAKYTVDQTWNRAIIQNVdVQQKKAHVLYIDYGNE 354
Cdd:cd20441     2 PSRFFIQL--SEDEKVILQLAEELNETSEKSRENAAVkLKVGDLVAAEYDEDLALYRAVITAV-LPGKSFKVEFIDYGNT 78

                          90       100       110
                  ....*....|....*....|....*....|
gi 767963288  355 EIIPLNRIYHLNRNIDLFPPCAIKCFVANV 384
Cdd:cd20441    79 AVVDKSNIYTLQEKFLSLPRLSIPCSLSGV 108

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410512 Cd Length: 108 Bit Score: 55.90 E-value: 2.78e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  951 SPNLFYAlpkGMPENQEKLCMLTAELLEYCNAPKSRPPYRPRIGDACCAKYTSDDFWYRAVVLG-TSDTDVEVLYADYGN 1029
Cdd:cd20441     1 SPSRFFI---QLSEDEKVILQLAEELNETSEKSRENAAVKLKVGDLVAAEYDEDLALYRAVITAvLPGKSFKVEFIDYGN 77

                          90       100       110
                  ....*....|....*....|....*....|.
gi 767963288 1030 IETLPLCRVQPITSSHLALPFQIIRCSLEGL 1060
Cdd:cd20441    78 TAVVDKSNIYTLQEKFLSLPRLSIPCSLSGV 108

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

Pssm-ID: 197660 Cd Length: 57 Bit Score: 53.82 E-value: 3.15e-09

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 767963288    542 PAIGDICCAQFsEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLMRLCPIIPKL 597
Cdd:smart00333    3 FKVGDKVAARW-EDGEWYRARIVKVDGEQLYEVFFIDYGNEEVVPPSDLRQLPEEL 57

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410480 Cd Length: 82 Bit Score: 54.38 E-value: 3.77e-09

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767963288  286 SEVLEYMNQLSASLKETYAnvhEKDYIPVKGEVCIAKYTVDQTWNRAIIQNVdVQQKKAHVLYIDYGNEEIIPLNRI 362
Cdd:cd20409     2 RQLAELQESLSAYCKVAPA---SSDFSPAVGEVCCAQFTEDNQWYRASVLAY-SSEDSVLVGYIDFGNSEEVALSRL 74

seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410513 Cd Length: 160 Bit Score: 56.97 E-value: 3.96e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  267 KGTVTEFKHPGDFYVQLY-SSEVLEYMNQLSASLKETYANVHEKDYipVKGEVCIAKYTVDQTWNRAIIQNVDVQQKKAH 345
Cdd:cd20442     5 KGTLLSVSKNGTFYVRLLrNSEQLTDLESLIAKEAKKCKFVPVEDI--KEGLECLAKSKKNLKWYRAVVEHLYPETEKML 82

                          90       100       110
                  ....*....|....*....|....*....|....
gi 767963288  346 VLYIDYGNEEIIPLNRIYHLNRNIDLFPPCAIKC 379
Cdd:cd20442    83 VFFVDHGITEVVSMGNIKQLSNDLLQIPRQAVLC 116

third Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410500 Cd Length: 91 Bit Score: 54.42 E-value: 5.07e-09

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767963288  776 DGSWYRALVKEILPNGHVKVHFVDYGNIEEVTADELRMISSTFLNLPFQGI 826
Cdd:cd20429    41 ENNWYRVLVKGILTNGLVSVYELDYGKHELVSIRKVQPLIEKFRQLPFQAI 91

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410506 Cd Length: 134 Bit Score: 55.72 E-value: 5.79e-09

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767963288  542 PAIGDICCAQfSEDDQWYRASVLAYASEES------VLVGYVDYGNFEILSLMRLCPIIPKLLELPMQAIKCVLAGVKP 614
Cdd:cd20435    50 VKVGDLCAVE-DENNLYHRVKVLEITEKDDktkpreVLVKFIDEGRVETVVVSQLLELPEELKSLPPQAVEVFLCNVKP 127

Tudor domain found in survival of motor neuron-related-splicing factor 30 (SPF30) and similar proteins; SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. Overexpression of SPF30 causes apoptosis. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410470 [Multi-domain] Cd Length: 55 Bit Score: 53.08 E-value: 5.80e-09

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767963288  765 IGQPCCAFFAGDGSWYRALVKEILPNGHVKVHFVDYGNIEEVTADELRMISS 816
Cdd:cd20399     3 VGDKCMAVWSEDGQYYEATIEEISEDGTCTVTFDGYGNTEVTPLSQLKPREE 54

first Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410515 Cd Length: 55 Bit Score: 53.08 E-value: 5.86e-09

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 767963288  313 PVKGEVCIAKYtvDQTWNRAIIQNVDVQQKKAHVLYIDYGNEEIIPLNRIY 363
Cdd:cd20444     1 PTPGQMVIAKF--DGNHYRAIVLRVLNPDLKILVRFVDFGNVEVMKLENLY 49

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410497 Cd Length: 140 Bit Score: 54.81 E-value: 1.36e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  266 IKGTVTEFKHPGDFYVQlYSSEVLEYMNQLSASLKETYANVHEKDYIPVKGEVCIAKYTVDQTWNRAIIQNVDvqQKKAH 345
Cdd:cd20426     1 IEAYATAVDSPEYFWCQ-FATEKIQCLAVKVQEAGEQVADRGNFIPSIYVGDPCIVKYSEDNHWYRALVTKIN--DNLVS 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 767963288  346 VLYIDYGNEEIIPLNRIYHLNRNIDLFPPCAIKCFVANVIPAEGNWSS 393
Cdd:cd20426    78 VRFVDYGNEEDVVREQVRALPSELLKIPVQAFPCCLSGFNLSEGLWSD 125

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410493 Cd Length: 135 Bit Score: 54.05 E-value: 2.10e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  990 RPRIGDACCAKYtSDDFWYRAVVLGTSDTDVEVLYADYGNIETLPLCRVQPITSSHLALPFQIIRCSLEGLMELNGSSSQ 1069
Cdd:cd20422    49 KPQPGQLCCAKW-KEDRYYRAIVTAVKGKMVEVFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCLADICPLGERWSP 127


                  ....*..
gi 767963288 1070 LIIMLLK 1076
Cdd:cd20422   128 EAISAFK 134

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410490 Cd Length: 118 Bit Score: 53.61 E-value: 2.13e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  270 VTEFKHPGDFYVQLYSSEVLEYMNQLSASLKETYANVHEKDYIP------VKGEVCIAKYTVDQTWNRAIIQNVdVQQKK 343
Cdd:cd20419     2 VEYIESPSQFYVRFYSKDTSEMLEDMMIEMRRCYSNEHVSERYVmpeafiQPGQVCCVRIPEDVWWYRVIIHQV-LNKQE 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 767963288  344 AHVLYIDYGNEEIIPLNRIYHLNRNIDLFPPCAIKC 379
Cdd:cd20419    81 VEVFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPA 116

second Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410499 Cd Length: 140 Bit Score: 53.99 E-value: 2.59e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  510 FCQQLQSG-RKLAELQASLSKYCDQLPPRSDFY---PAIGDICCAQFSedDQWYRASVLAYASEESVLVGYVDYGNFEIL 585
Cdd:cd20428    16 YCQVPSKGlSKLNEILDKIEYYFHSRQMTSEYFvslPFCGKICLARYK--GKWARVEITNVHSSRALDVHFLDTGTVASV 93

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 767963288  586 SLMRLCPIIPKLLE----LPMQAIKCVLAGVKPSLGIWTPEAI 624
Cdd:cd20428    94 KVSELREIPPPFLRelisIPPQALKCCLADLPLNIGMWTPDAV 136

Tudor domain found in survival motor neuron protein (SMN), motor neuron-related-splicing factor 30 (SPF30), and similar proteins; This group contains SMN, SPF30, Tudor domain-containing protein 3 (TDRD3), DNA excision repair protein ERCC-6-like 2 (ERCC6L2), and similar proteins. SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. ERCC6L2, also called DNA repair and recombination protein RAD26-like (RAD26L), may be involved in early DNA damage response. It regulates RNA Pol II-mediated transcription via its interaction with DNA-dependent protein kinase (DNA-PK) to resolve R loops and minimize transcription-associated genome instability. Members of this group contain a single Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410549 Cd Length: 50 Bit Score: 51.10 E-value: 2.67e-08

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 767963288  316 GEVCIAKYTVDQTWNRAIIQNVDVQQKKAHVLYIDYGNEEIIPLNRIYHL 365
Cdd:cd21182     1 GDKCLAPYSDDGKYYEATIEEITEESDTATVVFDGYGNSEEVPLSDLKPL 50

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410492 Cd Length: 130 Bit Score: 53.20 E-value: 3.59e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  499 VVAHIQTPEDFFCQQLQSGRKLAELQASLSKYCDQLPPRSDF-YPAIGDICCAQFSEDDQWYRASVL-AYASEESVLVGY 576
Cdd:cd20421    16 VVTEVTDPHRIFCQLRSLSQELKRLSESMHQYYEGRVGSGYEtRPEKLGSPCAARGSDGRWYRAVLQqVFSANRVVEVLH 95

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 767963288  577 VDYGNFEILSLMRLCPIIPKLLELPMQAIKCVLAG 611
Cdd:cd20421    96 VDYGRKEVVSVSNLRYLAPEYFRMPVVTYPCALFG 130

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410496 Cd Length: 115 Bit Score: 52.84 E-value: 4.00e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  943 QANVLEIISPNLFYAlpkGMPENQEKLCMLTAELleycNAPKSRPPYRP----RIGDACCAKYTSDDFWYRAVVL-GTSD 1017
Cdd:cd20425     3 EVYVSHVNSPSDFYV---QLAQDEDELSMISEKL----NASKANDEEVEceslQLGDLICAEYPEDGLWYRAVVKeKIPN 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 767963288 1018 TDVEVLYADYGNIETLPLCRVQPITSSHLALPFQIIRCSL 1057
Cdd:cd20425    76 NLVSVQFIDYGNTSVVQPSKIHRLPKELLSIPALSIHCFL 115

Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, also called serine/threonine-protein kinase (EC 2.7.11.1) 31 (STK31), serine/threonine-protein kinase NYD-SPK, or Sugen kinase 396 (SgK396), is a germ cell-specific factor expressed in embryonic gonocytes of both sexes, and in postnatal spermatocytes and round spermatids in males. It acts as a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells. TDRD8 contains a Tudor domain and a serine/threonine kinase domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410501 [Multi-domain] Cd Length: 75 Bit Score: 51.14 E-value: 4.53e-08

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767963288  748 SLAEHCQQKLPNGFKAEIGQPCCAFFAGDGSWYRALVKEILPNGHVKVHFVDYGNIEEVTADEL 811
Cdd:cd20430     4 ELAEVCPTAPPLFGTPDPNKIYGGKFSEDNCWYRCKVKSILSDEKCTVQYIDYGNTETVSRSSI 67

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410492 Cd Length: 130 Bit Score: 52.81 E-value: 5.60e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  935 ELPVDKTIQANVLEIISPNLFYALPKGMPENQEKLCMLTAELLEycNAPKSRPPYRPRIGDACCAKYTSDDFWYRAVVLG 1014
Cdd:cd20421     6 QLQVGVTETVVVTEVTDPHRIFCQLRSLSQELKRLSESMHQYYE--GRVGSGYETRPEKLGSPCAARGSDGRWYRAVLQQ 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 767963288 1015 T--SDTDVEVLYADYGNIETLPLCRVQPITSSHLALPFQIIRCSLEG 1059
Cdd:cd20421    84 VfsANRVVEVLHVDYGRKEVVSVSNLRYLAPEYFRMPVVTYPCALFG 130

Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410514 [Multi-domain] Cd Length: 117 Bit Score: 52.08 E-value: 5.97e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  757 LPNGFKAEIGQPCCAFFAGDGSWYRALVKE------ILPNGHVKVHFVDYGNIEEVTADELRMISSTFLNLPFQGIRCQL 830
Cdd:cd20443    32 PPGGFNPKKGELVLAQFSADNSWNRAMVVNaprqgtQSPKDEYEVFYIDYGNQETVPLSALRPLDPSVSSAPGLAQLCSL 111


                  ...
gi 767963288  831 ADI 833
Cdd:cd20443   112 AHI 114

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410489 Cd Length: 105 Bit Score: 51.64 E-value: 7.30e-08

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767963288  765 IGQPCCAFFAgDGSWYRALVKEILPNGHVK--VHFVDYGNIEEVTADELRMISSTFLNLPFQGIRCQLA 831
Cdd:cd20418     6 PEMPCLAEYS-DGKWYRAKLLSILEFNPVKilVRHVDYGSTAALPTSRLRQIPAELMQYPCQAIKVKLA 73

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410496 Cd Length: 115 Bit Score: 51.69 E-value: 8.11e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  276 PGDFYVQLYSSEVLeyMNQLSASLKETYANVHEKDYIPVK-GEVCIAKYTVDQTWNRAIiqnvdVQQKKA----HVLYID 350
Cdd:cd20425    12 PSDFYVQLAQDEDE--LSMISEKLNASKANDEEVECESLQlGDLICAEYPEDGLWYRAV-----VKEKIPnnlvSVQFID 84

                          90       100       110
                  ....*....|....*....|....*....|.
gi 767963288  351 YGNEEIIPLNRIYHLNRNIDLFPPCAIKCFV 381
Cdd:cd20425    85 YGNTSVVQPSKIHRLPKELLSIPALSIHCFL 115

Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410502 Cd Length: 101 Bit Score: 50.85 E-value: 1.25e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  948 EIISPNLFYALpKGMPENQEKLCMLTAELLEYCNAPksrPPYRPRIGDACCAKYTSDDF--WYRAVVLGTSDTDVEVLYA 1025
Cdd:cd20431     2 EVVEVGHFWGY-RIDENSSEILQQLTAEINQRQLVP---LTTKPVPNLLCLAPFTDADMkkYYRAKILYVSGSSAEVFFV 77

                          90       100
                  ....*....|....*....|....
gi 767963288 1026 DYGNIETLPLCRVQPITSSHLALP 1049
Cdd:cd20431    78 DYGNTSQVPSSLLREIPETLLTLP 101

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410498 Cd Length: 98 Bit Score: 50.12 E-value: 1.87e-07

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767963288  765 IGQpCCAFFAGDGSWYRALVKEILPNgHVKVHFVDYGNIEEVTADELRMISSTFLNLPFQGIRCQLADIQS 835
Cdd:cd20427    25 VGQ-LVAVKAEEDAWLRAQVIEVEED-KVKVYYVDHGFSEVVERSKLFKLNKQFYSLPFQATKCKLAGLEP 93

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410509 Cd Length: 141 Bit Score: 51.32 E-value: 2.21e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  276 PGDFYVQlysseVLEYMNQLSASLK---ETYANVHEKDYI---PVKGEVCIAKYTVDQTWNRAIIqnVDVQQKKAHVLYI 349
Cdd:cd20438    17 PSNFWIR-----TDEYNNEFQALMKniaDIYNLCGNDEELlkkPEPGLLCCARYSKDRHYYRAVI--TEVLDLKVSVYFL 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 767963288  350 DYGNEEIIPLNRIYHLNRNIDLFPPCAIKCFVANVIPAEGNW 391
Cdd:cd20438    90 DFGNTDTVPFYDVKTLLPEFSELPALAMCCSLAHVFPVEEVW 131

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410498 Cd Length: 98 Bit Score: 49.73 E-value: 2.92e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  975 ELLEYCNAPKSRPPYR-PRIGDACCAKyTSDDFWYRAVVLGTSDTDVEVLYADYGNIETLPLCRVQPITSSHLALPFQII 1053
Cdd:cd20427     6 EMKEFYSKSSTAMCLRsPSVGQLVAVK-AEEDAWLRAQVIEVEEDKVKVYYVDHGFSEVVERSKLFKLNKQFYSLPFQAT 84


                  ....*..
gi 767963288 1054 RCSLEGL 1060
Cdd:cd20427    85 KCKLAGL 91

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410495 Cd Length: 126 Bit Score: 50.58 E-value: 3.04e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  949 IISPNLFYAlpkGMPENQEKLCMLTAELLEYCNAPKS-RPPYRPriGDACCAKYTsDDFWYRAVVLgTSDTDVEVLYADY 1027
Cdd:cd20424    21 VNDPWTFYC---QLARNAGVLDQLASAISRLSSEIRKlELSVNP--GTLCLAKYS-DQHWYRGIII-TNKNSTEVFFVDY 93

                          90       100       110
                  ....*....|....*....|....*....|...
gi 767963288 1028 GNIETLPLCRVQPITSSH---LALPFQIIRCSL 1057
Cdd:cd20424    94 GNTEKVEKEDMLPIPSDAyelLLLPMQAIKCSL 126

first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410507 Cd Length: 147 Bit Score: 50.88 E-value: 3.04e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  275 HPGDFYVQLYSSEVLEYMNQLSASLKETYANVHEKDYIPVkGEVCIAKYTVDQTWNRAIIQNVdvQQKKAHVLYIDYGNE 354
Cdd:cd20436    10 HPKEVLVKFQGQYNSICELDYHILQNEIQNATKSKSSWGV-GEFCLVEDTTSGEWYRGRVLEK--IDEKYEVFLIDRGEV 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767963288  355 EIIPLNRIYHLNRNIDLFPPCAIKCFVANVIPAEGNWSSDCIKATKPLLMEQYC 408
Cdd:cd20436    87 LNVHATNMASASGELFQLPPKAVCGIFANILPIGEKWSSTAVNYFSSLIGSQVK 140

Tudor domain found in survival motor neuron protein (SMN), motor neuron-related-splicing factor 30 (SPF30), and similar proteins; This group contains SMN, SPF30, Tudor domain-containing protein 3 (TDRD3), DNA excision repair protein ERCC-6-like 2 (ERCC6L2), and similar proteins. SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. ERCC6L2, also called DNA repair and recombination protein RAD26-like (RAD26L), may be involved in early DNA damage response. It regulates RNA Pol II-mediated transcription via its interaction with DNA-dependent protein kinase (DNA-PK) to resolve R loops and minimize transcription-associated genome instability. Members of this group contain a single Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410549 Cd Length: 50 Bit Score: 48.02 E-value: 3.22e-07

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 767963288  766 GQPCCAFFAGDGSWYRALVKEI-LPNGHVKVHFVDYGNIEEVTADELRMI 814
Cdd:cd21182     1 GDKCLAPYSDDGKYYEATIEEItEESDTATVVFDGYGNSEEVPLSDLKPL 50

Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally identified in the Tudor protein of Drosophila, that adopts a beta-barrel-like core structure containing four short beta-strands followed by an alpha-helical region. It binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Tudor domain-containing proteins may mediate protein-protein interactions required for various DNA-templated biological processes, such as RNA metabolism, as well as histone modification and the DNA damage response. Members of this superfamily contain one or more copies of the Tudor domain.

Pssm-ID: 410449 [Multi-domain] Cd Length: 47 Bit Score: 47.58 E-value: 3.73e-07

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 767963288  766 GQPCCAFFAGDGSWYRALVKEILPNGHVKVHFvDYGNIEEVTADELRM 813
Cdd:cd04508     1 GDRVEAKWSDDGQWYPATVVAVNDDGKYTVLF-DDGNEEEVSEDDIRP 47

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

Pssm-ID: 197660 Cd Length: 57 Bit Score: 48.04 E-value: 4.05e-07

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 767963288    989 YRPRIGDACCAKYTsDDFWYRAVVLG-TSDTDVEVLYADYGNIETLPLCRVQPI 1041
Cdd:smart00333    1 PTFKVGDKVAARWE-DGEWYRARIVKvDGEQLYEVFFIDYGNEEVVPPSDLRQL 53

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410511 Cd Length: 127 Bit Score: 50.15 E-value: 4.13e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  946 VLEIISPNLFYAlpkGMPENQEKLCMLTAELLEYCNAPKSrPPYRPRIGDACCAKYTSDDFWYRAVVLGT-SDTDVEVLY 1024
Cdd:cd20440    16 ITHVYSPAKFYC---QLDRNTEILEALMEKIAEISKLFNS-QILDNCKTRLCLAKYFEDGQWYRALAHPVeSSSHLSVYF 91

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 767963288 1025 ADYGNIETLPLCRVQPI--TSSHLAL-PFQIIRCSL 1057
Cdd:cd20440    92 VDYGNKQIVEKNEVLPIpdTAVDLLLtPMQAIKCCL 127

Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope, where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. It contains a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410478 Cd Length: 76 Bit Score: 47.97 E-value: 6.54e-07

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767963288  996 ACCAKYTSDDfWYRAVVLGTS-DTD-VEVLYADYGNIETLPLCRVQPITSSHLALPFQIIRCSLEGLM 1061
Cdd:cd20407     9 VICAAPVMNA-WYRAQVVGVFeETDeVEIKYLDYGGYERVPVDDLRQIRSDFMTLPFQATECYLANIE 75

seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410513 Cd Length: 160 Bit Score: 49.65 E-value: 1.17e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  727 GEFYCHVLKEDalKKLNDLNKSLAEHC-QQKLPNGFKAEIGQPCCAFFAGDGSWYRALVKEILPN-GHVKVHFVDYGNIE 804
Cdd:cd20442    15 GTFYVRLLRNS--EQLTDLESLIAKEAkKCKFVPVEDIKEGLECLAKSKKNLKWYRAVVEHLYPEtEKMLVFFVDHGITE 92

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 767963288  805 EVTADELRMISSTFLNLPFQGIRCQLADIQSRNKH 839
Cdd:cd20442    93 VVSMGNIKQLSNDLLQIPRQAVLCRWNWPESSKEL 127

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410481 [Multi-domain] Cd Length: 59 Bit Score: 46.57 E-value: 1.28e-06

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 767963288  311 YIPVKGEVCIAKYTVDQTWNRAIIQNVdVQQKKAHVLYIDYGNEEIIPL 359
Cdd:cd20410     1 FKPIVGEPCCAFFSGDGNWYRAMVKEI-LPGGAVKVHFVDYGNVEEVTL 48

Tudor domain found in survival motor neuron protein (SMN), motor neuron-related-splicing factor 30 (SPF30), and similar proteins; This group contains SMN, SPF30, Tudor domain-containing protein 3 (TDRD3), DNA excision repair protein ERCC-6-like 2 (ERCC6L2), and similar proteins. SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. ERCC6L2, also called DNA repair and recombination protein RAD26-like (RAD26L), may be involved in early DNA damage response. It regulates RNA Pol II-mediated transcription via its interaction with DNA-dependent protein kinase (DNA-PK) to resolve R loops and minimize transcription-associated genome instability. Members of this group contain a single Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410549 Cd Length: 50 Bit Score: 46.09 E-value: 1.33e-06

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 767963288  545 GDICCAQFSEDDQWYRASVLA-YASEESVLVGYVDYGNFEILSLMRLCPI 593
Cdd:cd21182     1 GDKCLAPYSDDGKYYEATIEEiTEESDTATVVFDGYGNSEEVPLSDLKPL 50

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410492 Cd Length: 130 Bit Score: 48.57 E-value: 1.37e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  269 TVTEFKHPGDFYVQL--YSSEVleymNQLSASLKETYANVH---EKDYIPVKGEVCIAKyTVDQTWNRAIIQNVDVQQKK 343
Cdd:cd20421    16 VVTEVTDPHRIFCQLrsLSQEL----KRLSESMHQYYEGRVgsgYETRPEKLGSPCAAR-GSDGRWYRAVLQQVFSANRV 90

                          90       100
                  ....*....|....*....|..
gi 767963288  344 AHVLYIDYGNEEIIPLNRIYHL 365
Cdd:cd20421    91 VEVLHVDYGRKEVVSVSNLRYL 112

Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410502 Cd Length: 101 Bit Score: 47.38 E-value: 1.84e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  519 KLAELQASLSKYcDQLPPRSDFYPaiGDICCAQFSEDDQ--WYRASVLaYASEESVLVGYVDYGNFEILSLMRLCPIIPK 596
Cdd:cd20431    21 ILQQLTAEINQR-QLVPLTTKPVP--NLLCLAPFTDADMkkYYRAKIL-YVSGSSAEVFFVDYGNTSQVPSSLLREIPET 96


                  ....*
gi 767963288  597 LLELP 601
Cdd:cd20431    97 LLTLP 101

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410506 Cd Length: 134 Bit Score: 48.02 E-value: 2.22e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  294 QLSASLKETYAN-----VHEKdyiPVKGEVCIAKYTvDQTWNRAIIQNVDVQQKKAH-----VLYIDYGNEEIIPLNRIY 363
Cdd:cd20435    29 KLSMKLNMYYSDpsnriLHGK---VKVGDLCAVEDE-NNLYHRVKVLEITEKDDKTKprevlVKFIDEGRVETVVVSQLL 104

                          90       100
                  ....*....|....*....|...
gi 767963288  364 HLNRNIDLFPPCAIKCFVANVIP 386
Cdd:cd20435   105 ELPEELKSLPPQAVEVFLCNVKP 127

fourth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410488 Cd Length: 68 Bit Score: 45.89 E-value: 2.82e-06

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767963288  994 GDACCAKyTSDDFWYRAVVLGTSDTDVEVLYADYGNIETLPLCRVQPIT----SSHLALPFQI 1052
Cdd:cd20417     4 GEGCVVR-GSDTLWYRGKVLEVIGGMVRVQYVDQGYIEKIPQCHLYPMVlypdIPQFCIPCQL 65

Tudor domain found in survival motor neuron protein (SMN) and similar proteins; SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Mutations in human SMN lead to motor neuron degeneration and spinal muscular atrophy. SMN contains a central, highly conserved Tudor domain that is required for U snRNP assembly and Sm protein binding and has been shown to bind arginine-glycine-rich motifs in an methylarginine-dependent manner.

Pssm-ID: 410469 Cd Length: 56 Bit Score: 45.34 E-value: 3.23e-06

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767963288  544 IGDICCAQFSEDDQWYRASVLA-YASEESVLVGYVDYGNFEILSLMRLCPIIPK 596
Cdd:cd20398     3 VGDKCRAVYSEDGIIYEATIVSiDAERGTCVVRYTGYGNEEEQNLSDLLPPSGE 56

first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410507 Cd Length: 147 Bit Score: 48.19 E-value: 3.40e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  543 AIGDICCAQFSEDDQWYRASVLAyASEESVLVGYVDYGNFEILSLMRLCPIIPKLLELPMQAIKCVLAGVKPSLGIWTPE 622
Cdd:cd20436    48 GVGEFCLVEDTTSGEWYRGRVLE-KIDEKYEVFLIDRGEVLNVHATNMASASGELFQLPPKAVCGIFANILPIGEKWSST 126


                  ....*....
gi 767963288  623 AICLMKKLV 631
Cdd:cd20436   127 AVNYFSSLI 135

Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410502 Cd Length: 101 Bit Score: 46.61 E-value: 3.46e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  723 IYSPGEFYCHVLKEDALKKLNDLNKSLAEHCQQKL-----PNGFkaeigqpCCAFFAgDGS---WYRALVKEILPNGhVK 794
Cdd:cd20431     3 VVEVGHFWGYRIDENSSEILQQLTAEINQRQLVPLttkpvPNLL-------CLAPFT-DADmkkYYRAKILYVSGSS-AE 73

                          90       100
                  ....*....|....*....|....*...
gi 767963288  795 VHFVDYGNIEEVTADELRMISSTFLNLP 822
Cdd:cd20431    74 VFFVDYGNTSQVPSSLLREIPETLLTLP 101

Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, also called serine/threonine-protein kinase (EC 2.7.11.1) 31 (STK31), serine/threonine-protein kinase NYD-SPK, or Sugen kinase 396 (SgK396), is a germ cell-specific factor expressed in embryonic gonocytes of both sexes, and in postnatal spermatocytes and round spermatids in males. It acts as a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells. TDRD8 contains a Tudor domain and a serine/threonine kinase domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410501 [Multi-domain] Cd Length: 75 Bit Score: 45.75 E-value: 3.47e-06

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 767963288  313 PVKGEVCIAKYTVDQTWNRAIIQNVDvQQKKAHVLYIDYGNEEII 357
Cdd:cd20430    19 PDPNKIYGGKFSEDNCWYRCKVKSIL-SDEKCTVQYIDYGNTETV 62

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410506 Cd Length: 134 Bit Score: 47.63 E-value: 3.85e-06

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767963288  770 CAFFAGDGSWYRALVKEILPNGH------VKVHFVDYGNIEEVTADELRMISSTFLNLPFQGI 826
Cdd:cd20435    56 CAVEDENNLYHRVKVLEITEKDDktkpreVLVKFIDEGRVETVVVSQLLELPEELKSLPPQAV 118

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410489 Cd Length: 105 Bit Score: 46.63 E-value: 4.30e-06

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767963288  992 RIGDACCAKYtSDDFWYRAVVLGTSD-TDVEVL--YADYGNIETLPLCRVQPITSSHLALPFQIIRCSLEGL 1060
Cdd:cd20418     5 RPEMPCLAEY-SDGKWYRAKLLSILEfNPVKILvrHVDYGSTAALPTSRLRQIPAELMQYPCQAIKVKLAGF 75

Tudor domain found in Tudor domain-containing protein 3 (TDRD3) and similar proteins; TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In the nucleus, it acts as a coactivator; it recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In the cytoplasm, it may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. TDRD3 contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410484 Cd Length: 53 Bit Score: 45.03 E-value: 4.61e-06

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 767963288  766 GQPCCAFFAGDGSWYRALVKEILPNGHVK-VHFVDYGNIEEVTADELRMI 814
Cdd:cd20413     4 GDECLAKYWEDNKFYRAEVTAVHPSGKTAvVKFMEYGNYEEVLLSDIKPI 53

Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410502 Cd Length: 101 Bit Score: 46.23 E-value: 4.91e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  271 TEFKHPGDFYVQLYSSEVLEYMNQLSASLKE-TYANVHEKdyiPVKGEVCIAKYT--VDQTWNRAIIQNVDVQQkkAHVL 347
Cdd:cd20431     1 TEVVEVGHFWGYRIDENSSEILQQLTAEINQrQLVPLTTK---PVPNLLCLAPFTdaDMKKYYRAKILYVSGSS--AEVF 75

                          90       100
                  ....*....|....*....|...
gi 767963288  348 YIDYGNEEIIPLnriyHLNRNID 370
Cdd:cd20431    76 FVDYGNTSQVPS----SLLREIP 94

Tudor domain found in survival motor neuron protein (SMN), motor neuron-related-splicing factor 30 (SPF30), and similar proteins; This group contains SMN, SPF30, Tudor domain-containing protein 3 (TDRD3), DNA excision repair protein ERCC-6-like 2 (ERCC6L2), and similar proteins. SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. ERCC6L2, also called DNA repair and recombination protein RAD26-like (RAD26L), may be involved in early DNA damage response. It regulates RNA Pol II-mediated transcription via its interaction with DNA-dependent protein kinase (DNA-PK) to resolve R loops and minimize transcription-associated genome instability. Members of this group contain a single Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410549 Cd Length: 50 Bit Score: 44.55 E-value: 5.12e-06

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 767963288  994 GDACCAKYTSDDFWYRAVV--LGTSDTDVEVLYADYGNIETLPLCRVQPI 1041
Cdd:cd21182     1 GDKCLAPYSDDGKYYEATIeeITEESDTATVVFDGYGNSEEVPLSDLKPL 50

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410511 Cd Length: 127 Bit Score: 46.68 E-value: 5.76e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  270 VTEFKHPGDFYVQLYSSEvlEYMNQLSASLKETYANVHEKDYIPVKGEVCIAKYTVDQTWNRAIIQNVDVQQkKAHVLYI 349
Cdd:cd20440    16 ITHVYSPAKFYCQLDRNT--EILEALMEKIAEISKLFNSQILDNCKTRLCLAKYFEDGQWYRALAHPVESSS-HLSVYFV 92

                          90       100       110
                  ....*....|....*....|....*....|....
gi 767963288  350 DYGNEEIIPLNRIYHLNR---NIDLFPPCAIKCF 380
Cdd:cd20440    93 DYGNKQIVEKNEVLPIPDtavDLLLTPMQAIKCC 126

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410495 Cd Length: 126 Bit Score: 46.73 E-value: 6.13e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  270 VTEFKHPGDFYVQL-YSSEVLEYMNQLSASLKETYANvHEKDYIPvkGEVCIAKYTvDQTWNRAIIQNvdvQQKKAHVLY 348
Cdd:cd20424    18 ITYVNDPWTFYCQLaRNAGVLDQLASAISRLSSEIRK-LELSVNP--GTLCLAKYS-DQHWYRGIIIT---NKNSTEVFF 90

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 767963288  349 IDYGN------EEIIPL-NRIYHLNrnidLFPPCAIKC 379
Cdd:cd20424    91 VDYGNtekvekEDMLPIpSDAYELL----LLPMQAIKC 124

seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410513 Cd Length: 160 Bit Score: 47.73 E-value: 6.24e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  497 CGVVAHIQTPEDFFCQQLQSGRKLAELQASLSKYCdqlpPRSDFYPAI----GDICCAQFSEDDQWYRASVL-AYASEES 571
Cdd:cd20442     5 KGTLLSVSKNGTFYVRLLRNSEQLTDLESLIAKEA----KKCKFVPVEdikeGLECLAKSKKNLKWYRAVVEhLYPETEK 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 767963288  572 VLVGYVDYGNFEILSLMRLCPIIPKLLELPMQAIKC 607
Cdd:cd20442    81 MLVFFVDHGITEVVSMGNIKQLSNDLLQIPRQAVLC 116

first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410507 Cd Length: 147 Bit Score: 47.03 E-value: 7.67e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  716 VDVVVCVIYSPGEFYCHVLKEDalKKLNDLN-KSLAEHCQQKLPNGFKAEIGQPCCAFFAGDGSWYRALVKEILpNGHVK 794
Cdd:cd20436     1 DLKITHRVCHPKEVLVKFQGQY--NSICELDyHILQNEIQNATKSKSSWGVGEFCLVEDTTSGEWYRGRVLEKI-DEKYE 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767963288  795 VHFVDYGNIEEVTADELRMISSTFLNLPFQGIRCQLADIQSRNKHWSEEAITRF 848
Cdd:cd20436    78 VFLIDRGEVLNVHATNMASASGELFQLPPKAVCGIFANILPIGEKWSSTAVNYF 131

Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, also called serine/threonine-protein kinase (EC 2.7.11.1) 31 (STK31), serine/threonine-protein kinase NYD-SPK, or Sugen kinase 396 (SgK396), is a germ cell-specific factor expressed in embryonic gonocytes of both sexes, and in postnatal spermatocytes and round spermatids in males. It acts as a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells. TDRD8 contains a Tudor domain and a serine/threonine kinase domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410501 [Multi-domain] Cd Length: 75 Bit Score: 44.20 E-value: 1.37e-05

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767963288  972 LTAELLEYCnaPKSRPPYR-PRIGDACCAKYTSDDFWYRAVVLGT-SDTDVEVLYADYGNIETL 1033
Cdd:cd20430     1 LSDELAEVC--PTAPPLFGtPDPNKIYGGKFSEDNCWYRCKVKSIlSDEKCTVQYIDYGNTETV 62

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410486 Cd Length: 96 Bit Score: 44.73 E-value: 1.38e-05

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767963288  308 EKDYIPVKGEVCIAKYTvDQTWNRAIIQNVdVQQKKAHVLYIDYGNEEIIPLNRIYHLNRNIDLFPPCAIKCFVANVIP 386
Cdd:cd20415    20 LEILCPVQGQACVALFE-DGAWYRARIIGL-PGHREVEVKYVDFGNTATVTIKHVRKIKDDFLSLPEKARECRLAFIEP 96

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410508 Cd Length: 120 Bit Score: 45.10 E-value: 2.21e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  268 GTVTEFK-----HPGDFYVQLYSSEvlEYMNQLSASLKETYANVhEKDYIPVK---GEVCIAKYTvDQTWNRAIIQNV-- 337
Cdd:cd20437     2 GTTEKVKitaavSPSKFYCQLLSWE--PELSKLTTQMTLHYESV-SKELNPSCenfGLLCAAKGK-DGQWHRGFLQQLlp 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 767963288  338 DVQQKkahVLYIDYGNEEIIPLNRIYHLNRNIDLFP----PCAIKC 379
Cdd:cd20437    78 PSQVK---VWFIDYGNSEAVSSHSVLKLPPDFFSLPlmsfPCSLSC 120

Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally identified in the Tudor protein of Drosophila, that adopts a beta-barrel-like core structure containing four short beta-strands followed by an alpha-helical region. It binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Tudor domain-containing proteins may mediate protein-protein interactions required for various DNA-templated biological processes, such as RNA metabolism, as well as histone modification and the DNA damage response. Members of this superfamily contain one or more copies of the Tudor domain.

Pssm-ID: 410449 [Multi-domain] Cd Length: 47 Bit Score: 41.80 E-value: 4.07e-05

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 767963288  994 GDACCAKYTSDDFWYRAVVLGTSDTD-VEVLYaDYGNIETLPLCRVQP 1040
Cdd:cd04508     1 GDRVEAKWSDDGQWYPATVVAVNDDGkYTVLF-DDGNEEEVSEDDIRP 47

second Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410516 Cd Length: 56 Bit Score: 42.03 E-value: 4.77e-05

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 767963288  777 GSWYRALVKEILPNGHVKVHFVDYGNIEEVTADELRMISSTFLNLP 822
Cdd:cd20445    11 DKWYRAVCLESVGDGRPTVLFCDYGNILMARLTDIRPFPPTFATEP 56

Tudor domain found in Tudor domain-containing protein 3 (TDRD3) and similar proteins; TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In the nucleus, it acts as a coactivator; it recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In the cytoplasm, it may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. TDRD3 contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410484 Cd Length: 53 Bit Score: 41.56 E-value: 7.50e-05

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767963288  992 RIGDACCAKYTSDDFWYRAVV--LGTSDTDVEVLYADYGNIETLPLCRVQPI 1041
Cdd:cd20413     2 KPGDECLAKYWEDNKFYRAEVtaVHPSGKTAVVKFMEYGNYEEVLLSDIKPI 53

Tudor domain found in survival of motor neuron-related-splicing factor 30 (SPF30) and similar proteins; SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. Overexpression of SPF30 causes apoptosis. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410470 [Multi-domain] Cd Length: 55 Bit Score: 41.52 E-value: 7.93e-05

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 767963288  544 IGDICCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLMRLCP 592
Cdd:cd20399     3 VGDKCMAVWSEDGQYYEATIEEISEDGTCTVTFDGYGNTEVTPLSQLKP 51

Tudor domain found in survival motor neuron protein (SMN) and similar proteins; SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Mutations in human SMN lead to motor neuron degeneration and spinal muscular atrophy. SMN contains a central, highly conserved Tudor domain that is required for U snRNP assembly and Sm protein binding and has been shown to bind arginine-glycine-rich motifs in an methylarginine-dependent manner.

Pssm-ID: 410469 Cd Length: 56 Bit Score: 41.10 E-value: 1.14e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767963288  316 GEVCIAKYTVDQTWNRAIIQNVDVQQKKAHVLYIDYGNEEIIPLNriyhlnrniDLFPP 374
Cdd:cd20398     4 GDKCRAVYSEDGIIYEATIVSIDAERGTCVVRYTGYGNEEEQNLS---------DLLPP 53

Tudor domain found in Tudor domain-containing protein 3 (TDRD3) and similar proteins; TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In the nucleus, it acts as a coactivator; it recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In the cytoplasm, it may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. TDRD3 contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410484 Cd Length: 53 Bit Score: 40.40 E-value: 2.01e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 767963288  315 KGEVCIAKYTVDQTWNRAIIQNVDVQQKKAHVLYIDYGNEE 355
Cdd:cd20413     3 PGDECLAKYWEDNKFYRAEVTAVHPSGKTAVVKFMEYGNYE 43

Tudor domain found in survival motor neuron protein (SMN) and similar proteins; SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Mutations in human SMN lead to motor neuron degeneration and spinal muscular atrophy. SMN contains a central, highly conserved Tudor domain that is required for U snRNP assembly and Sm protein binding and has been shown to bind arginine-glycine-rich motifs in an methylarginine-dependent manner.

Pssm-ID: 410469 Cd Length: 56 Bit Score: 39.95 E-value: 2.97e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767963288  764 EIGQPCCAFFAGDGSWYRALVKEI-LPNGHVKVHFVDYGNIEEVTADELRMISST 817
Cdd:cd20398     2 KVGDKCRAVYSEDGIIYEATIVSIdAERGTCVVRYTGYGNEEEQNLSDLLPPSGE 56

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410508 Cd Length: 120 Bit Score: 41.63 E-value: 2.98e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  950 ISPNLFYALPKGMpenQEKLCMLTAELLEYCNA-PKSRPPYRPRIGDACCAKyTSDDFWYRAVVLGT-SDTDVEVLYADY 1027
Cdd:cd20437    13 VSPSKFYCQLLSW---EPELSKLTTQMTLHYESvSKELNPSCENFGLLCAAK-GKDGQWHRGFLQQLlPPSQVKVWFIDY 88

                          90       100       110
                  ....*....|....*....|....*....|
gi 767963288 1028 GNIETLPLCRVQPITSSHLALPFQIIRCSL 1057
Cdd:cd20437    89 GNSEAVSSHSVLKLPPDFFSLPLMSFPCSL 118

first Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410515 Cd Length: 55 Bit Score: 39.21 E-value: 4.40e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767963288  542 PAIGDICCAQFseDDQWYRASVL-AYASEESVLVGYVDYGNFEILSLMRL--CP 592
Cdd:cd20444     1 PTPGQMVIAKF--DGNHYRAIVLrVLNPDLKILVRFVDFGNVEVMKLENLyeCP 52

Tudor domain found in Tudor domain-containing protein 3 (TDRD3) and similar proteins; TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In the nucleus, it acts as a coactivator; it recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In the cytoplasm, it may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. TDRD3 contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410484 Cd Length: 53 Bit Score: 39.25 E-value: 4.58e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 767963288  545 GDICCAQFSEDDQWYRASVLAYASEESV-LVGYVDYGNFEILSLMRLCPI 593
Cdd:cd20413     4 GDECLAKYWEDNKFYRAEVTAVHPSGKTaVVKFMEYGNYEEVLLSDIKPI 53

third Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410500 Cd Length: 91 Bit Score: 40.16 E-value: 6.40e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767963288  547 ICCAQFseDDQWYRASVLAYASEESVLVGYVDYGNFEILSLMRLCPIIPKLLELPMQAI 605
Cdd:cd20429    35 VYAAKI--ENNWYRVLVKGILTNGLVSVYELDYGKHELVSIRKVQPLIEKFRQLPFQAI 91

seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410513 Cd Length: 160 Bit Score: 41.56 E-value: 7.36e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  969 LCMLTAELLEYCnapKSRPPYRPRIGDACCAKYTSDDFWYRAVVLGTSDTD--VEVLYADYGNIETLPLCRVQPITSSHL 1046
Cdd:cd20442    31 LESLIAKEAKKC---KFVPVEDIKEGLECLAKSKKNLKWYRAVVEHLYPETekMLVFFVDHGITEVVSMGNIKQLSNDLL 107

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 767963288 1047 ALPFQIIRCSLEGLMELNGSSSQliimLLKNFMLNQNVML 1086
Cdd:cd20442   108 QIPRQAVLCRWNWPESSKELSFE----ILWKSLAGKEVKL 143

Tudor domain found in survival of motor neuron-related-splicing factor 30 (SPF30) and similar proteins; SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. Overexpression of SPF30 causes apoptosis. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410470 [Multi-domain] Cd Length: 55 Bit Score: 38.44 E-value: 8.41e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767963288  992 RIGDACCAKYTSDDFWYRAVVLGTS-DTDVEVLYADYGNIETLPLCRVQPITSS 1044
Cdd:cd20399     2 KVGDKCMAVWSEDGQYYEATIEEISeDGTCTVTFDGYGNTEVTPLSQLKPREEG 55

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410506 Cd Length: 134 Bit Score: 40.70 E-value: 9.84e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  944 ANVLEIISPNLfyALPKGMPENQEKLCMltaELLEYCNAPKSRPPY-RPRIGDACCAKYTSDDFwYRAVVLG--TSDTD- 1019
Cdd:cd20435     7 ARILEHRSSDG--EVTKSMSSTYLKLSM---KLNMYYSDPSNRILHgKVKVGDLCAVEDENNLY-HRVKVLEitEKDDKt 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 767963288 1020 ----VEVLYADYGNIET--------LP--------------LCRVQPI 1041
Cdd:cd20435    81 kpreVLVKFIDEGRVETvvvsqlleLPeelkslppqavevfLCNVKPV 128

second Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410516 Cd Length: 56 Bit Score: 38.17 E-value: 1.07e-03

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 767963288  997 CCAKYtsDDFWYRAVVL-GTSDTDVEVLYADYGNIETLPLCRVQPIT 1042
Cdd:cd20445     5 CIAKY--MDKWYRAVCLeSVGDGRPTVLFCDYGNILMARLTDIRPFP 49

Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally identified in the Tudor protein of Drosophila, that adopts a beta-barrel-like core structure containing four short beta-strands followed by an alpha-helical region. It binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Tudor domain-containing proteins may mediate protein-protein interactions required for various DNA-templated biological processes, such as RNA metabolism, as well as histone modification and the DNA damage response. Members of this superfamily contain one or more copies of the Tudor domain.

Pssm-ID: 410449 [Multi-domain] Cd Length: 47 Bit Score: 37.95 E-value: 1.19e-03

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 767963288  545 GDICCAQFSEDDQWYRASVLAYASEESVLVGYvDYGNFEILSLMRLCP 592
Cdd:cd04508     1 GDRVEAKWSDDGQWYPATVVAVNDDGKYTVLF-DDGNEEEVSEDDIRP 47

fourth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410488 Cd Length: 68 Bit Score: 38.19 E-value: 1.51e-03

                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 767963288  770 CAFFAGDGSWYRALVKEILpNGHVKVHFVDYGNIEEV 806
Cdd:cd20417     7 CVVRGSDTLWYRGKVLEVI-GGMVRVQYVDQGYIEKI 42

first Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the first/N-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410505 Cd Length: 164 Bit Score: 40.48 E-value: 1.73e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  718 VVVCVIYSPGEFYCHVLK--------EDALKKLND-LNKSLAEHCQQ----KLPNgfkAEIGQPCCAFFAGDGSWYRALV 784
Cdd:cd20434     1 IQVLKIEDPGCFWGRILKgsgdlvvnPEEYENLQDeMNQFYHKGYKDveeiKPST---LEEGQVCVVFCEELKCWCRAVV 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 767963288  785 KEILPNGH---VKVHFVDYGNIEEVTADELRMISSTFLNLPFQGIRCQLADIQ 834
Cdd:cd20434    78 ESLMSSADdylAECFLVDYAKYIPVKSKDIRVALEAFMKLPYRAKKFRLYGIK 130

Tudor domain found in Tudor domain-containing protein 10 (TDRD10) and similar proteins; TDRD10 is widely expressed and localized both to the nucleus and cytoplasm, and may play general roles like regulation of RNA metabolism. It contains a Tudor domain and an RNA recognition motif (RRM). The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410503 Cd Length: 139 Bit Score: 39.72 E-value: 2.12e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963288  252 FSDLRSLQLkkTMEIKGT----VTE-FKHPGDFYVQLYSSEVLEYMNQLSASLKETYANVH--EKDYIpVKGEVCIAKYT 324
Cdd:cd20432     6 FGDLSWLAS--IMKVHGEvgllVTDtFPHTPYFWAILLTEESQQNMQQLFSTLAEVESQQPflAKEDV-HRGRRCLAECP 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 767963288  325 VDQ---TWNRAIIqnVDVQQKKAHVLYIDYGNEEIIPLNRIYHLN 366
Cdd:cd20432    83 LGEeggAWNRCWV--LDVVEDFAVVFFVDFGSTANIPLPSLRSLD 125

Tudor domain found in survival motor neuron protein (SMN) and similar proteins; SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Mutations in human SMN lead to motor neuron degeneration and spinal muscular atrophy. SMN contains a central, highly conserved Tudor domain that is required for U snRNP assembly and Sm protein binding and has been shown to bind arginine-glycine-rich motifs in an methylarginine-dependent manner.

Pssm-ID: 410469 Cd Length: 56 Bit Score: 37.25 E-value: 2.64e-03

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 767963288  992 RIGDACCAKYTSDDFWYRAVVL---GTSDTDVeVLYADYGNIETLPLCRVQPITSS 1044
Cdd:cd20398     2 KVGDKCRAVYSEDGIIYEATIVsidAERGTCV-VRYTGYGNEEEQNLSDLLPPSGE 56

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410498 Cd Length: 98 Bit Score: 38.18 E-value: 3.70e-03

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767963288  320 IAKYTVDQTWNRAiiQNVDVQQKKAHVLYIDYGNEEIIPLNRIYHLNRNIDLFPPCAIKCFVA 382
Cdd:cd20427    29 VAVKAEEDAWLRA--QVIEVEEDKVKVYYVDHGFSEVVERSKLFKLNKQFYSLPFQATKCKLA 89

second Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410516 Cd Length: 56 Bit Score: 36.63 E-value: 4.82e-03

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767963288  317 EVCIAKYtvDQTWNRAI-IQNVDvqQKKAHVLYIDYGNEEIIPLNriyhlnrNIDLFPP 374
Cdd:cd20445     3 ELCIAKY--MDKWYRAVcLESVG--DGRPTVLFCDYGNILMARLT-------DIRPFPP 50

first Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410515 Cd Length: 55 Bit Score: 35.74 E-value: 7.07e-03

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767963288  765 IGQPCCAFFagDGSWYRALVKEIL-PNGHVKVHFVDYGNIEEVTADELRMISSTF 818
Cdd:cd20444     3 PGQMVIAKF--DGNHYRAIVLRVLnPDLKILVRFVDFGNVEVMKLENLYECPEYL 55

Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally identified in the Tudor protein of Drosophila, that adopts a beta-barrel-like core structure containing four short beta-strands followed by an alpha-helical region. It binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Tudor domain-containing proteins may mediate protein-protein interactions required for various DNA-templated biological processes, such as RNA metabolism, as well as histone modification and the DNA damage response. Members of this superfamily contain one or more copies of the Tudor domain.

Pssm-ID: 410449 [Multi-domain] Cd Length: 47 Bit Score: 35.64 E-value: 7.35e-03

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 767963288  316 GEVCIAKYTVDQTWNRAIIQNVDVQQkKAHVLYiDYGNEEIIPLNRIY 363
Cdd:cd04508     1 GDRVEAKWSDDGQWYPATVVAVNDDG-KYTVLF-DDGNEEEVSEDDIR 46