|
Name |
Accession |
Description |
Interval |
E-value |
| DEXHc_HARP_SMARCAL1 |
cd18010 |
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ... |
426-635 |
1.18e-112 |
|
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350768 [Multi-domain] Cd Length: 213 Bit Score: 344.96 E-value: 1.18e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 426 LMPFQRAGVNFAIAKGGRLLLADDMGLGKTIQAICIAAFYRKEWPLLVVVPSSVRFTWEQAFLRWLPSLSPDCINVVVTG 505
Cdd:cd18010 1 LLPFQREGVCFALRRGGRVLIADEMGLGKTVQAIAIAAYYREEWPLLIVCPSSLRLTWADEIERWLPSLPPDDIQVIVKS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 506 KDRLTAG--LINIVSFDLLSKLERQL-KTPFKVVIIDESHFLKNSRTARCRAAMPVLKVAKRVILLSGTPAMSRPAELYT 582
Cdd:cd18010 81 KDGLRDGdaKVVIVSYDLLRRLEKQLlARKFKVVICDESHYLKNSKAKRTKAALPLLKRAKRVILLSGTPALSRPIELFT 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 795612006 583 QIIAVKPTFFPQFHAFGLRYCDAKRMPWGWDYSGSSNLGELKLLLEEAVMLRR 635
Cdd:cd18010 161 QLDALDPKLFGRFHDFGRRYCAAKQGGFGWDYSGSSNLEELHLLLLATIMIRR 213
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
413-846 |
6.75e-83 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 281.73 E-value: 6.75e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 413 ADLSEVDPKLVSNLMPFQRAGVNFAIAK---GGRLLLADDMGLGKTIQAICIAAFYRKE---WPLLVVVPSSVRFTWEQA 486
Cdd:COG0553 229 EALESLPAGLKATLRPYQLEGAAWLLFLrrlGLGGLLADDMGLGKTIQALALLLELKERglaRPVLIVAPTSLVGNWQRE 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 487 FLRWLPSLSPdcinVVVTGKDRLTAGL-------INIVSFDLLSKLERQLK-TPFKVVIIDESHFLKNSRTARCRAAMpV 558
Cdd:COG0553 309 LAKFAPGLRV----LVLDGTRERAKGAnpfedadLVITSYGLLRRDIELLAaVDWDLVILDEAQHIKNPATKRAKAVR-A 383
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 559 LKvAKRVILLSGTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRYCDAKRmpwgwdySGSSNLGELKLLLEEAVMLRRLKS 638
Cdd:COG0553 384 LK-ARHRLALTGTPVENRLEELWSLLDFLNPGLLGSLKAFRERFARPIE-------KGDEEALERLRRLLRPFLLRRTKE 455
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 639 DVLSQLPAKQRKIVVIAPGRINARTRAALDAAAKEMATTDKTKQQQK---DALI----------LFFNRTAEAKIPS--- 702
Cdd:COG0553 456 DVLKDLPEKTEETLYVELTPEQRALYEAVLEYLRRELEGAEGIRRRGlilAALTrlrqicshpaLLLEEGAELSGRSakl 535
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 703 --VIEYILDLLESGrEKFLVFAHHKVVLDAITQELERKHVQHIRIDGSTSSAEREDLCQQFQLSERHAVAVLSITAANMG 780
Cdd:COG0553 536 eaLLELLEELLAEG-EKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPEAPVFLISLKAGGEG 614
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 795612006 781 LTFSSADLVVFAELFWNPGVLIQAEDRVHRIGQTSSVGIHYLVAKGTADDYLWPLIQEKIKvLAEA 846
Cdd:COG0553 615 LNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEEKRA-LAES 679
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
698-823 |
1.09e-45 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 160.33 E-value: 1.09e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 698 AKIPSVIEYILDLLESGrEKFLVFAHHKVVLDAITQELERKHVQHIRIDGSTSSAEREDLCQQFQLSERHAVAVLSITAA 777
Cdd:cd18793 11 GKLEALLELLEELREPG-EKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDIRVFLLSTKAG 89
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 795612006 778 NMGLTFSSADLVVFAELFWNPGVLIQAEDRVHRIGQTSSVGIHYLV 823
Cdd:cd18793 90 GVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
|
|
| HARP |
pfam07443 |
HepA-related protein (HARP); This family represents a conserved region approximately 60 ... |
238-292 |
7.80e-28 |
|
HepA-related protein (HARP); This family represents a conserved region approximately 60 residues long within eukaryotic HepA-related protein (HARP). This exhibits single-stranded DNA-dependent ATPase activity, and is ubiquitously expressed in human and mouse tissues. Family members may contain more than one copy of this region.
Pssm-ID: 462166 Cd Length: 55 Bit Score: 106.48 E-value: 7.80e-28
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 795612006 238 FQVLIGYNAELIAVFKSLPSKRYDPDTKTWNFSMNDYSALMKAAQSLPTVNLQPL 292
Cdd:pfam07443 1 FEVEIGYHAELIAVFKQMPSRNYDPKTKKWNFSLEDYSKLMEAARALPQVELEPL 55
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
429-840 |
1.13e-26 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 117.59 E-value: 1.13e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 429 FQRAGVNFAI---AKGGRLLLADDMGLGKTIQAICIAAF---YRK-EWPLLVVVPSSVRFTWEQAFLRWLPSLSPdcINV 501
Cdd:PLN03142 173 YQLAGLNWLIrlyENGINGILADEMGLGKTLQTISLLGYlheYRGiTGPHMVVAPKSTLGNWMNEIRRFCPVLRA--VKF 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 502 VVTGKDR-------LTAGLINIV--SFDLLSKLERQLKT-PFKVVIIDESHFLKNSRTaRCRAAMPVLKVAKRvILLSGT 571
Cdd:PLN03142 251 HGNPEERahqreelLVAGKFDVCvtSFEMAIKEKTALKRfSWRYIIIDEAHRIKNENS-LLSKTMRLFSTNYR-LLITGT 328
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 572 PAMSRPAELYTQIIAVKPTFFPQFHAFGlrycdakrmpwGWDYSGSSNLGELKLLLEEAV----MLRRLKSDVLSQLPAK 647
Cdd:PLN03142 329 PLQNNLHELWALLNFLLPEIFSSAETFD-----------EWFQISGENDQQEVVQQLHKVlrpfLLRRLKSDVEKGLPPK 397
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 648 QRKIVVIAPGRINARTRAAL--------DAAAKEMATTDKTKQQQKDALILFFNRTAEAKIP-----SVIE-----YILD 709
Cdd:PLN03142 398 KETILKVGMSQMQKQYYKALlqkdldvvNAGGERKRLLNIAMQLRKCCNHPYLFQGAEPGPPyttgeHLVEnsgkmVLLD 477
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 710 -LLESGREK---FLVFAHHKVVLDAITQELERKHVQHIRIDGSTSSAEREDLCQQFQL--SERHaVAVLSITAANMGLTF 783
Cdd:PLN03142 478 kLLPKLKERdsrVLIFSQMTRLLDILEDYLMYRGYQYCRIDGNTGGEDRDASIDAFNKpgSEKF-VFLLSTRAGGLGINL 556
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 795612006 784 SSADLVVFAELFWNPGVLIQAEDRVHRIGQTSSVGIHYLVAKGTaddylwplIQEKI 840
Cdd:PLN03142 557 ATADIVILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFRFCTEYT--------IEEKV 605
|
|
| HARP |
pfam07443 |
HepA-related protein (HARP); This family represents a conserved region approximately 60 ... |
333-387 |
1.69e-26 |
|
HepA-related protein (HARP); This family represents a conserved region approximately 60 residues long within eukaryotic HepA-related protein (HARP). This exhibits single-stranded DNA-dependent ATPase activity, and is ubiquitously expressed in human and mouse tissues. Family members may contain more than one copy of this region.
Pssm-ID: 462166 Cd Length: 55 Bit Score: 102.63 E-value: 1.69e-26
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 795612006 333 FEADIGYSQDLIALFKQMDSRRYDVKTRKWSFLLEEHSKLIAKVRCLPQVQLDPL 387
Cdd:pfam07443 1 FEVEIGYHAELIAVFKQMPSRNYDPKTKKWNFSLEDYSKLMEAARALPQVELEPL 55
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
430-652 |
7.59e-23 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 99.68 E-value: 7.59e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 430 QRAGVNFAIAK------GGrlLLADDMGLGKTIQAICIAAF---YRKEW--PLLVVVPSSVRFTWEQAFLRWL--PSLSP 496
Cdd:pfam00176 2 QIEGVNWMLSLennlgrGG--ILADEMGLGKTLQTISLLLYlkhVDKNWggPTLIVVPLSLLHNWMNEFERWVspPALRV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 497 DCI-------NVVVTGKDRLTAGLINIVSFDLLSKLERQL-KTPFKVVIIDESHFLKNSRtARCRAAMPVLKVAKRvILL 568
Cdd:pfam00176 80 VVLhgnkrpqERWKNDPNFLADFDVVITTYETLRKHKELLkKVHWHRIVLDEGHRLKNSK-SKLSKALKSLKTRNR-WIL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 569 SGTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRYCDAKRMPwgwdysGSSNLGELKLLLEEAVMLRRLKSDVLSQLPAKQ 648
Cdd:pfam00176 158 TGTPLQNNLEELWALLNFLRPGPFGSLSTFRNWFDRPIERG------GGKKGVSRLHKLLKPFLLRRTKKDVEKSLPPKV 231
|
....
gi 795612006 649 RKIV 652
Cdd:pfam00176 232 EYIL 235
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
702-812 |
6.19e-19 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 83.03 E-value: 6.19e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 702 SVIEYILDLLESGR-EKFLVFAHHKVVLDAiTQELERKHVQHIRIDGSTSSAEREDLCQQFQLSERHAVavLSITAANMG 780
Cdd:pfam00271 1 EKLEALLELLKKERgGKVLIFSQTKKTLEA-ELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVL--VATDVAERG 77
|
90 100 110
....*....|....*....|....*....|..
gi 795612006 781 LTFSSADLVVFAELFWNPGVLIQAEDRVHRIG 812
Cdd:pfam00271 78 LDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
418-572 |
3.31e-18 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 84.08 E-value: 3.31e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 418 VDPKLVSNLMPFQRAGVNFAIAKGGRLLLADDMGLGKTIQA---ICIAAFYRKEWPLLVVVP-SSVRFTWEQAFLRWLPS 493
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSGLRDVILAAPTGSGKTLAAllpALEALKRGKGGRVLVLVPtRELAEQWAEELKKLGPS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 494 LSPDCINVVVTGK-----DRLTAGLINIV-----SFDLLSKLERQLKTPFKVVIIDESHFLKN-SRTARCRAAMPVLKVA 562
Cdd:smart00487 81 LGLKVVGLYGGDSkreqlRKLESGKTDILvttpgRLLDLLENDKLSLSNVDLVILDEAHRLLDgGFGDQLEKLLKLLPKN 160
|
170
....*....|
gi 795612006 563 KRVILLSGTP 572
Cdd:smart00487 161 VQLLLLSATP 170
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
729-812 |
1.18e-15 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 72.63 E-value: 1.18e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 729 DAITQELERKHVQHIRIDGSTSSAEREDLCQQFQlsERHAVAVLSITAANMGLTFSSADLVVFAELFWNPGVLIQAEDRV 808
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFN--NGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRA 78
|
....
gi 795612006 809 HRIG 812
Cdd:smart00490 79 GRAG 82
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
426-810 |
2.01e-12 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 70.82 E-value: 2.01e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 426 LMPFQRAGVNFAIA----KGGRLLLADDMGLGKTIQAICIAAFYRKEWPLLVVVPS-SVRFTWEQAFLRWLPslspdciN 500
Cdd:COG1061 81 LRPYQQEALEALLAalerGGGRGLVVAPTGTGKTVLALALAAELLRGKRVLVLVPRrELLEQWAEELRRFLG-------D 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 501 VVVTGKDRLTAGLINIVSFDLLSKLE--RQLKTPFKVVIIDESHFLKNSRTARCRAAMPvlkvAKRVILLSGTP----AM 574
Cdd:COG1061 154 PLAGGGKKDSDAPITVATYQSLARRAhlDELGDRFGLVIIDEAHHAGAPSYRRILEAFP----AAYRLGLTATPfrsdGR 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 575 SRPAELYTQIIavkptffpqfhaFGLRYCDAkrmpwgwdysgssnlgelkllleeavmlrrLKSDVLSQlpakqrkivvi 654
Cdd:COG1061 230 EILLFLFDGIV------------YEYSLKEA------------------------------IEDGYLAP----------- 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 655 apgrinARTRAALDAAAKEMATTDKTKQQQKDALIlffnRTAEAKIPSVIEYILDllESGREKFLVFAHHKVVLDAITQE 734
Cdd:COG1061 257 ------PEYYGIRVDLTDERAEYDALSERLREALA----ADAERKDKILRELLRE--HPDDRKTLVFCSSVDHAEALAEL 324
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 795612006 735 LERKHVQHIRIDGSTSSAEREDLCQQFqlSERHAVAVLSITAANMGLTFSSADLVVFAELFWNPGVLIQAEDRVHR 810
Cdd:COG1061 325 LNEAGIRAAVVTGDTPKKEREEILEAF--RDGELRILVTVDVLNEGVDVPRLDVAILLRPTGSPREFIQRLGRGLR 398
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
699-895 |
1.85e-03 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 42.17 E-value: 1.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 699 KIPSVIEYILD-LLESGREKFLVFAHHKVVLDAITQELERKHVQHIRIDGSTSSAEREDLCQQFQL-------SERHAVA 770
Cdd:PRK13766 348 KLEKLREIVKEqLGKNPDSRIIVFTQYRDTAEKIVDLLEKEGIKAVRFVGQASKDGDKGMSQKEQIeildkfrAGEFNVL 427
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 771 VlSITAANMGLTFSSADLVVFAElfwnPgvlIQAEDR-VHRIGQT--SSVG-IHYLVAKGTADD-YLWPLI------QEK 839
Cdd:PRK13766 428 V-STSVAEEGLDIPSVDLVIFYE----P---VPSEIRsIQRKGRTgrQEEGrVVVLIAKGTRDEaYYWSSRrkekkmKEE 499
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 795612006 840 IKVLAEAgLSETNFSEMTESTDYLYKDPKQQKIYDlFQKSFEKEGSDMELLEAAET 895
Cdd:PRK13766 500 LKNLKGI-LNKKLQELDEEQKGEEEEKDEQLSLDD-FVKSKGKEEEEEEEKEEKDK 553
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| DEXHc_HARP_SMARCAL1 |
cd18010 |
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ... |
426-635 |
1.18e-112 |
|
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350768 [Multi-domain] Cd Length: 213 Bit Score: 344.96 E-value: 1.18e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 426 LMPFQRAGVNFAIAKGGRLLLADDMGLGKTIQAICIAAFYRKEWPLLVVVPSSVRFTWEQAFLRWLPSLSPDCINVVVTG 505
Cdd:cd18010 1 LLPFQREGVCFALRRGGRVLIADEMGLGKTVQAIAIAAYYREEWPLLIVCPSSLRLTWADEIERWLPSLPPDDIQVIVKS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 506 KDRLTAG--LINIVSFDLLSKLERQL-KTPFKVVIIDESHFLKNSRTARCRAAMPVLKVAKRVILLSGTPAMSRPAELYT 582
Cdd:cd18010 81 KDGLRDGdaKVVIVSYDLLRRLEKQLlARKFKVVICDESHYLKNSKAKRTKAALPLLKRAKRVILLSGTPALSRPIELFT 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 795612006 583 QIIAVKPTFFPQFHAFGLRYCDAKRMPWGWDYSGSSNLGELKLLLEEAVMLRR 635
Cdd:cd18010 161 QLDALDPKLFGRFHDFGRRYCAAKQGGFGWDYSGSSNLEELHLLLLATIMIRR 213
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
413-846 |
6.75e-83 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 281.73 E-value: 6.75e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 413 ADLSEVDPKLVSNLMPFQRAGVNFAIAK---GGRLLLADDMGLGKTIQAICIAAFYRKE---WPLLVVVPSSVRFTWEQA 486
Cdd:COG0553 229 EALESLPAGLKATLRPYQLEGAAWLLFLrrlGLGGLLADDMGLGKTIQALALLLELKERglaRPVLIVAPTSLVGNWQRE 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 487 FLRWLPSLSPdcinVVVTGKDRLTAGL-------INIVSFDLLSKLERQLK-TPFKVVIIDESHFLKNSRTARCRAAMpV 558
Cdd:COG0553 309 LAKFAPGLRV----LVLDGTRERAKGAnpfedadLVITSYGLLRRDIELLAaVDWDLVILDEAQHIKNPATKRAKAVR-A 383
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 559 LKvAKRVILLSGTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRYCDAKRmpwgwdySGSSNLGELKLLLEEAVMLRRLKS 638
Cdd:COG0553 384 LK-ARHRLALTGTPVENRLEELWSLLDFLNPGLLGSLKAFRERFARPIE-------KGDEEALERLRRLLRPFLLRRTKE 455
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 639 DVLSQLPAKQRKIVVIAPGRINARTRAALDAAAKEMATTDKTKQQQK---DALI----------LFFNRTAEAKIPS--- 702
Cdd:COG0553 456 DVLKDLPEKTEETLYVELTPEQRALYEAVLEYLRRELEGAEGIRRRGlilAALTrlrqicshpaLLLEEGAELSGRSakl 535
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 703 --VIEYILDLLESGrEKFLVFAHHKVVLDAITQELERKHVQHIRIDGSTSSAEREDLCQQFQLSERHAVAVLSITAANMG 780
Cdd:COG0553 536 eaLLELLEELLAEG-EKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPEAPVFLISLKAGGEG 614
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 795612006 781 LTFSSADLVVFAELFWNPGVLIQAEDRVHRIGQTSSVGIHYLVAKGTADDYLWPLIQEKIKvLAEA 846
Cdd:COG0553 615 LNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEEKRA-LAES 679
|
|
| DEXHc_Snf |
cd17919 |
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ... |
426-592 |
8.31e-46 |
|
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350677 [Multi-domain] Cd Length: 182 Bit Score: 162.35 E-value: 8.31e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 426 LMPFQRAGVNFAI---AKGGRLLLADDMGLGKTIQAICIAAFYRKE----WPLLVVVPSSVRFTWEQAFLRWLPSLSPdc 498
Cdd:cd17919 1 LRPYQLEGLNFLLelyENGPGGILADEMGLGKTLQAIAFLAYLLKEgkerGPVLVVCPLSVLENWEREFEKWTPDLRV-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 499 inVVVTG----------KDRLTAGLINIVSFDLLSKLERQL-KTPFKVVIIDESHFLKNSRTARCRAAMPVLkvAKRVIL 567
Cdd:cd17919 79 --VVYHGsqreraqiraKEKLDKFDVVLTTYETLRRDKASLrKFRWDLVVVDEAHRLKNPKSQLSKALKALR--AKRRLL 154
|
170 180
....*....|....*....|....*
gi 795612006 568 LSGTPAMSRPAELYTQIIAVKPTFF 592
Cdd:cd17919 155 LTGTPLQNNLEELWALLDFLDPPFL 179
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
698-823 |
1.09e-45 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 160.33 E-value: 1.09e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 698 AKIPSVIEYILDLLESGrEKFLVFAHHKVVLDAITQELERKHVQHIRIDGSTSSAEREDLCQQFQLSERHAVAVLSITAA 777
Cdd:cd18793 11 GKLEALLELLEELREPG-EKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDIRVFLLSTKAG 89
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 795612006 778 NMGLTFSSADLVVFAELFWNPGVLIQAEDRVHRIGQTSSVGIHYLV 823
Cdd:cd18793 90 GVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
|
|
| HARP |
pfam07443 |
HepA-related protein (HARP); This family represents a conserved region approximately 60 ... |
238-292 |
7.80e-28 |
|
HepA-related protein (HARP); This family represents a conserved region approximately 60 residues long within eukaryotic HepA-related protein (HARP). This exhibits single-stranded DNA-dependent ATPase activity, and is ubiquitously expressed in human and mouse tissues. Family members may contain more than one copy of this region.
Pssm-ID: 462166 Cd Length: 55 Bit Score: 106.48 E-value: 7.80e-28
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 795612006 238 FQVLIGYNAELIAVFKSLPSKRYDPDTKTWNFSMNDYSALMKAAQSLPTVNLQPL 292
Cdd:pfam07443 1 FEVEIGYHAELIAVFKQMPSRNYDPKTKKWNFSLEDYSKLMEAARALPQVELEPL 55
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
429-840 |
1.13e-26 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 117.59 E-value: 1.13e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 429 FQRAGVNFAI---AKGGRLLLADDMGLGKTIQAICIAAF---YRK-EWPLLVVVPSSVRFTWEQAFLRWLPSLSPdcINV 501
Cdd:PLN03142 173 YQLAGLNWLIrlyENGINGILADEMGLGKTLQTISLLGYlheYRGiTGPHMVVAPKSTLGNWMNEIRRFCPVLRA--VKF 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 502 VVTGKDR-------LTAGLINIV--SFDLLSKLERQLKT-PFKVVIIDESHFLKNSRTaRCRAAMPVLKVAKRvILLSGT 571
Cdd:PLN03142 251 HGNPEERahqreelLVAGKFDVCvtSFEMAIKEKTALKRfSWRYIIIDEAHRIKNENS-LLSKTMRLFSTNYR-LLITGT 328
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 572 PAMSRPAELYTQIIAVKPTFFPQFHAFGlrycdakrmpwGWDYSGSSNLGELKLLLEEAV----MLRRLKSDVLSQLPAK 647
Cdd:PLN03142 329 PLQNNLHELWALLNFLLPEIFSSAETFD-----------EWFQISGENDQQEVVQQLHKVlrpfLLRRLKSDVEKGLPPK 397
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 648 QRKIVVIAPGRINARTRAAL--------DAAAKEMATTDKTKQQQKDALILFFNRTAEAKIP-----SVIE-----YILD 709
Cdd:PLN03142 398 KETILKVGMSQMQKQYYKALlqkdldvvNAGGERKRLLNIAMQLRKCCNHPYLFQGAEPGPPyttgeHLVEnsgkmVLLD 477
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 710 -LLESGREK---FLVFAHHKVVLDAITQELERKHVQHIRIDGSTSSAEREDLCQQFQL--SERHaVAVLSITAANMGLTF 783
Cdd:PLN03142 478 kLLPKLKERdsrVLIFSQMTRLLDILEDYLMYRGYQYCRIDGNTGGEDRDASIDAFNKpgSEKF-VFLLSTRAGGLGINL 556
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 795612006 784 SSADLVVFAELFWNPGVLIQAEDRVHRIGQTSSVGIHYLVAKGTaddylwplIQEKI 840
Cdd:PLN03142 557 ATADIVILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFRFCTEYT--------IEEKV 605
|
|
| HARP |
pfam07443 |
HepA-related protein (HARP); This family represents a conserved region approximately 60 ... |
333-387 |
1.69e-26 |
|
HepA-related protein (HARP); This family represents a conserved region approximately 60 residues long within eukaryotic HepA-related protein (HARP). This exhibits single-stranded DNA-dependent ATPase activity, and is ubiquitously expressed in human and mouse tissues. Family members may contain more than one copy of this region.
Pssm-ID: 462166 Cd Length: 55 Bit Score: 102.63 E-value: 1.69e-26
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 795612006 333 FEADIGYSQDLIALFKQMDSRRYDVKTRKWSFLLEEHSKLIAKVRCLPQVQLDPL 387
Cdd:pfam07443 1 FEVEIGYHAELIAVFKQMPSRNYDPKTKKWNFSLEDYSKLMEAARALPQVELEPL 55
|
|
| DEXQc_arch_SWI2_SNF2 |
cd18012 |
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ... |
422-637 |
5.39e-26 |
|
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350770 [Multi-domain] Cd Length: 218 Bit Score: 106.88 E-value: 5.39e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 422 LVSNLMPFQRAGVNF--AIAK---GGrlLLADDMGLGKTIQAIC-IAAFYRKEW--PLLVVVPSSVRFTWEQAFLRWLPS 493
Cdd:cd18012 1 LKATLRPYQKEGFNWlsFLRHyglGG--ILADDMGLGKTLQTLAlLLSRKEEGRkgPSLVVAPTSLIYNWEEEAAKFAPE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 494 LspdciNVVV---TGKDRLTAGLIN-----IVSFDLLSKLERQLKT-PFKVVIIDESHFLKNSRTARCRAAMpVLKVAKR 564
Cdd:cd18012 79 L-----KVLVihgTKRKREKLRALEdydlvITSYGLLRRDIELLKEvKFHYLVLDEAQNIKNPQTKTAKAVK-ALKADHR 152
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 795612006 565 vILLSGTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRYcdakRMPwgWDYSGSSNLGELKLLLEEAVMLRRLK 637
Cdd:cd18012 153 -LALTGTPIENHLGELWSIFDFLNPGLLGSYKRFKKRF----AKP--IEKDGDEEALEELKKLISPFILRRLK 218
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
430-652 |
7.59e-23 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 99.68 E-value: 7.59e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 430 QRAGVNFAIAK------GGrlLLADDMGLGKTIQAICIAAF---YRKEW--PLLVVVPSSVRFTWEQAFLRWL--PSLSP 496
Cdd:pfam00176 2 QIEGVNWMLSLennlgrGG--ILADEMGLGKTLQTISLLLYlkhVDKNWggPTLIVVPLSLLHNWMNEFERWVspPALRV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 497 DCI-------NVVVTGKDRLTAGLINIVSFDLLSKLERQL-KTPFKVVIIDESHFLKNSRtARCRAAMPVLKVAKRvILL 568
Cdd:pfam00176 80 VVLhgnkrpqERWKNDPNFLADFDVVITTYETLRKHKELLkKVHWHRIVLDEGHRLKNSK-SKLSKALKSLKTRNR-WIL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 569 SGTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRYCDAKRMPwgwdysGSSNLGELKLLLEEAVMLRRLKSDVLSQLPAKQ 648
Cdd:pfam00176 158 TGTPLQNNLEELWALLNFLRPGPFGSLSTFRNWFDRPIERG------GGKKGVSRLHKLLKPFLLRRTKKDVEKSLPPKV 231
|
....
gi 795612006 649 RKIV 652
Cdd:pfam00176 232 EYIL 235
|
|
| DEXDc_RapA |
cd18011 |
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ... |
426-592 |
8.86e-22 |
|
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350769 [Multi-domain] Cd Length: 207 Bit Score: 94.28 E-value: 8.86e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 426 LMPFQRAGVNFAIAKG-GRLLLADDMGLGKTIQAICIAAFYRKEW---PLLVVVPSSVRFTW--EQAFLRWLPSLSPDCI 499
Cdd:cd18011 1 PLPHQIDAVLRALRKPpVRLLLADEVGLGKTIEAGLIIKELLLRGdakRVLILCPASLVEQWqdELQDKFGLPFLILDRE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 500 NV---VVTGKDRLTAGLINIVSFDLLSKLERQ----LKTPFKVVIIDESHFLKNSR----TARCRAAMPVLKVAKRVILL 568
Cdd:cd18011 81 TAaqlRRLIGNPFEEFPIVIVSLDLLKRSEERrgllLSEEWDLVVVDEAHKLRNSGggkeTKRYKLGRLLAKRARHVLLL 160
|
170 180
....*....|....*....|....
gi 795612006 569 SGTPAMSRPAELYTQIIAVKPTFF 592
Cdd:cd18011 161 TATPHNGKEEDFRALLSLLDPGRF 184
|
|
| DEXHc_RAD54 |
cd18004 |
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ... |
426-602 |
6.94e-20 |
|
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350762 [Multi-domain] Cd Length: 240 Bit Score: 90.04 E-value: 6.94e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 426 LMPFQRAGVNF--------AIAKGGRLLLADDMGLGKTIQAICIAafyrkeWPLL--------------VVVPSSVRFTW 483
Cdd:cd18004 1 LRPHQREGVQFlydcltgrRGYGGGGAILADEMGLGKTLQAIALV------WTLLkqgpygkptakkalIVCPSSLVGNW 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 484 EQAFLRWLP-------SLSPDCINVVVTGKDRLTAGL--INIVSFDLLSKLERQLKTP--FKVVIIDESHFLKNSRTaRC 552
Cdd:cd18004 75 KAEFDKWLGlrrikvvTADGNAKDVKASLDFFSSASTypVLIISYETLRRHAEKLSKKisIDLLICDEGHRLKNSES-KT 153
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 795612006 553 RAAMPVLKVAKRvILLSGTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRY 602
Cdd:cd18004 154 TKALNSLPCRRR-LLLTGTPIQNDLDEFFALVDFVNPGILGSLASFRKVF 202
|
|
| DEXHc_ATRX-like |
cd18007 |
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ... |
426-592 |
1.50e-19 |
|
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350765 [Multi-domain] Cd Length: 239 Bit Score: 88.89 E-value: 1.50e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 426 LMPFQRAGVNF----------AIAKGGRLLLADDMGLGKTIQAICI-----AAFYRKEWPLlVVVPSSVRFTWEQAFLRW 490
Cdd:cd18007 1 LKPHQVEGVRFlwsnlvgtdvGSDEGGGCILAHTMGLGKTLQVITFlhtylAAAPRRSRPL-VLCPASTLYNWEDEFKKW 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 491 LPSLSPDCINVVV-----TGKDRLTA-------GLINIVSFDLLSKL----------------ERQLKTPfKVVIIDESH 542
Cdd:cd18007 80 LPPDLRPLLVLVSlsaskRADARLRKinkwhkeGGVLLIGYELFRNLasnattdprlkqefiaALLDPGP-DLLVLDEGH 158
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 795612006 543 FLKNSRTARCRAAMpvlKV-AKRVILLSGTPAMSRPAELYTQIIAVKPTFF 592
Cdd:cd18007 159 RLKNEKSQLSKALS---KVkTKRRILLTGTPLQNNLKEYWTMVDFARPKYL 206
|
|
| DEXHc_SMARCAD1 |
cd17998 |
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ... |
426-592 |
2.31e-19 |
|
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350756 [Multi-domain] Cd Length: 187 Bit Score: 86.67 E-value: 2.31e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 426 LMPFQRAGVNFAI---AKGGRLLLADDMGLGKTIQAICIAAfYRKE----WPLLVVVPSSVRFTWEQAFLRWLPSLSPDC 498
Cdd:cd17998 1 LKDYQLIGLNWLNllyQKKLSGILADEMGLGKTIQVIAFLA-YLKEigipGPHLVVVPSSTLDNWLREFKRWCPSLKVEP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 499 ---------------------INVVVTgkdrlTAGLINIVSFDllSKLERQLKtpFKVVIIDESHFLKNSRTARCRAAMp 557
Cdd:cd17998 80 yygsqeerkhlrydilkgledFDVIVT-----TYNLATSNPDD--RSFFKRLK--LNYVVYDEGHMLKNMTSERYRHLM- 149
|
170 180 190
....*....|....*....|....*....|....*
gi 795612006 558 VLKVAKRvILLSGTPAMSRPAELYTQIIAVKPTFF 592
Cdd:cd17998 150 TINANFR-LLLTGTPLQNNLLELMSLLNFIMPKPF 183
|
|
| DEXDc_SHPRH-like |
cd18008 |
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ... |
426-635 |
3.56e-19 |
|
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350766 [Multi-domain] Cd Length: 241 Bit Score: 87.73 E-value: 3.56e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 426 LMPFQRAGVNFAIAKGGrlLLADDMGLGKTIQAI-CIAA------FYRKEWPL--------------LVVVPSSVRFTWE 484
Cdd:cd18008 1 LLPYQKQGLAWMLPRGG--ILADEMGLGKTIQALaLILAtrpqdpKIPEELEEnssdpkklylskttLIVVPLSLLSQWK 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 485 Q--------AFLRWL----------PSLSPDCiNVVVTGKDRLTAGLINIVSFDLLSKLERQ----LKTPFKVVIIDESH 542
Cdd:cd18008 79 DeiekhtkpGSLKVYvyhgskriksIEELSDY-DIVITTYGTLASEFPKNKKGGGRDSKEKEasplHRIRWYRVILDEAH 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 543 FLKNSRTARCRAAMpVLKvAKRVILLSGTPAMSRPAELYTQIIavkptfFPQFHAFGLRYCDAKRMPWGWDYsGSSNLGE 622
Cdd:cd18008 158 NIKNRSTKTSRAVC-ALK-AERRWCLTGTPIQNSLDDLYSLLR------FLRVEPFGDYPWFNSDISKPFSK-NDRKALE 228
|
250
....*....|...
gi 795612006 623 LKLLLEEAVMLRR 635
Cdd:cd18008 229 RLQALLKPILLRR 241
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
702-812 |
6.19e-19 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 83.03 E-value: 6.19e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 702 SVIEYILDLLESGR-EKFLVFAHHKVVLDAiTQELERKHVQHIRIDGSTSSAEREDLCQQFQLSERHAVavLSITAANMG 780
Cdd:pfam00271 1 EKLEALLELLKKERgGKVLIFSQTKKTLEA-ELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVL--VATDVAERG 77
|
90 100 110
....*....|....*....|....*....|..
gi 795612006 781 LTFSSADLVVFAELFWNPGVLIQAEDRVHRIG 812
Cdd:pfam00271 78 LDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEXHc_Mot1 |
cd17999 |
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ... |
426-581 |
6.97e-19 |
|
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350757 [Multi-domain] Cd Length: 232 Bit Score: 86.64 E-value: 6.97e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 426 LMPFQRAGVN---FAIAKGGRLLLADDMGLGKTIQAICIAA---FYRKEW------PLLVVVPSSVRFTWEQAFLRWLPS 493
Cdd:cd17999 1 LRPYQQEGINwlaFLNKYNLHGILCDDMGLGKTLQTLCILAsdhHKRANSfnsenlPSLVVCPPTLVGHWVAEIKKYFPN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 494 LSPDCINVVVTGKDR------LTAGLINIVSFDLLSK-LERQLKTPFKVVIIDESHFLKNSRTaRCRAAMPVLKVAKRVI 566
Cdd:cd17999 81 AFLKPLAYVGPPQERrrlreqGEKHNVIVASYDVLRNdIEVLTKIEWNYCVLDEGHIIKNSKT-KLSKAVKQLKANHRLI 159
|
170
....*....|....*
gi 795612006 567 lLSGTPAMSRPAELY 581
Cdd:cd17999 160 -LSGTPIQNNVLELW 173
|
|
| DEXQc_SRCAP |
cd18003 |
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ... |
426-598 |
1.93e-18 |
|
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350761 [Multi-domain] Cd Length: 223 Bit Score: 85.10 E-value: 1.93e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 426 LMPFQRAGVNFAIA---KGGRLLLADDMGLGKTIQAICIAAF---YRKEW-PLLVVVPSSVRFTWEQAFLRWLPSL---- 494
Cdd:cd18003 1 LREYQHIGLDWLATlyeKNLNGILADEMGLGKTIQTIALLAHlacEKGNWgPHLIVVPTSVMLNWEMEFKRWCPGFkilt 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 495 ---SPDCINVVVTGKDRLTAGLINIVSFDLLSKLERQLK-TPFKVVIIDESHFLKNSRTARCRAampVLKV-AKRVILLS 569
Cdd:cd18003 81 yygSAKERKLKRQGWMKPNSFHVCITSYQLVVQDHQVFKrKKWKYLILDEAHNIKNFKSQRWQT---LLNFnTQRRLLLT 157
|
170 180
....*....|....*....|....*....
gi 795612006 570 GTPAMSRPAELYTQIIAVKPTFFPQFHAF 598
Cdd:cd18003 158 GTPLQNSLMELWSLMHFLMPHIFQSHQEF 186
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
418-572 |
3.31e-18 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 84.08 E-value: 3.31e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 418 VDPKLVSNLMPFQRAGVNFAIAKGGRLLLADDMGLGKTIQA---ICIAAFYRKEWPLLVVVP-SSVRFTWEQAFLRWLPS 493
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSGLRDVILAAPTGSGKTLAAllpALEALKRGKGGRVLVLVPtRELAEQWAEELKKLGPS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 494 LSPDCINVVVTGK-----DRLTAGLINIV-----SFDLLSKLERQLKTPFKVVIIDESHFLKN-SRTARCRAAMPVLKVA 562
Cdd:smart00487 81 LGLKVVGLYGGDSkreqlRKLESGKTDILvttpgRLLDLLENDKLSLSNVDLVILDEAHRLLDgGFGDQLEKLLKLLPKN 160
|
170
....*....|
gi 795612006 563 KRVILLSGTP 572
Cdd:smart00487 161 VQLLLLSATP 170
|
|
| DEXHc_CHD6_7_8_9 |
cd17995 |
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ... |
426-606 |
3.43e-18 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350753 [Multi-domain] Cd Length: 223 Bit Score: 84.61 E-value: 3.43e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 426 LMPFQRAGVN---FAIAKGGRLLLADDMGLGKTIQAIC----IAAFYRKEWPLLVVVPSSVRFTWEQAFLRWLpslspdC 498
Cdd:cd17995 1 LRDYQLEGVNwllFNWYNRRNCILADEMGLGKTIQSIAflehLYQVEGIRGPFLVIAPLSTIPNWQREFETWT------D 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 499 INVVV---TGKDRLTAGLI-------------NIVSFDLL--------SKLERQLKTPFKVVIIDESHFLKNsrtaRCRA 554
Cdd:cd17995 75 MNVVVyhgSGESRQIIQQYemyfkdaqgrkkkGVYKFDVLittyemviADAEELRKIPWRVVVVDEAHRLKN----RNSK 150
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 795612006 555 AMPVLKVAK--RVILLSGTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRYCDAK 606
Cdd:cd17995 151 LLQGLKKLTleHKLLLTGTPLQNNTEELWSLLNFLEPEKFPSSEEFLEEFGDLK 204
|
|
| DEXQc_bact_SNF2 |
cd18013 |
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ... |
428-584 |
2.72e-17 |
|
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350771 [Multi-domain] Cd Length: 218 Bit Score: 81.63 E-value: 2.72e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 428 PFQRAGVNFAIA-KGGRLLLadDMGLGKT------IQAICIAAFYRkewPLLVVVPSSV-RFTWEQAFLRWlpSLSPDCI 499
Cdd:cd18013 3 PYQKVAINFIIEhPYCGLFL--DMGLGKTvttltaLSDLQLDDFTR---RVLVIAPLRVaRSTWPDEVEKW--NHLRNLT 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 500 NVVVTGKDRLTAGLIN------IVSFDLLSKL-ERQLKT-PFKVVIIDESHFLKNSRTARCRAAMPVLKVAKRVILLSGT 571
Cdd:cd18013 76 VSVAVGTERQRSKAANtpadlyVINRENLKWLvNKSGDPwPFDMVVIDELSSFKSPRSKRFKALRKVRPVIKRLIGLTGT 155
|
170
....*....|...
gi 795612006 572 PAMSRPAELYTQI 584
Cdd:cd18013 156 PSPNGLMDLWAQI 168
|
|
| DEXHc_ERCC6L |
cd18001 |
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ... |
426-581 |
4.54e-17 |
|
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350759 [Multi-domain] Cd Length: 232 Bit Score: 81.26 E-value: 4.54e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 426 LMPFQRAGVNFAIA-----KGGrlLLADDMGLGKTIQAIC-IAAFYRKEW--PLLVVVPSSVRFTWEQAFLRWLPSLspd 497
Cdd:cd18001 1 LYPHQREGVAWLWSlhdggKGG--ILADDMGLGKTVQICAfLSGMFDSGLikSVLVVMPTSLIPHWVKEFAKWTPGL--- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 498 ciNVVV------TGKDR-----LTAGLINIVSFDLLSKLERQLKTPFK------VVIIDESHFLKNS--RTARCRAAMPv 558
Cdd:cd18001 76 --RVKVfhgtskKERERnleriQRGGGVLLTTYGMVLSNTEQLSADDHdefkwdYVILDEGHKIKNSktKSAKSLREIP- 152
|
170 180
....*....|....*....|...
gi 795612006 559 lkvAKRVILLSGTPAMSRPAELY 581
Cdd:cd18001 153 ---AKNRIILTGTPIQNNLKELW 172
|
|
| DEXHc_SMARCA2_SMARCA4 |
cd17996 |
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ... |
445-598 |
1.30e-16 |
|
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350754 [Multi-domain] Cd Length: 233 Bit Score: 80.11 E-value: 1.30e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 445 LLADDMGLGKTIQAICIAA----FYRKEWPLLVVVPSSVRFTWEQAFLRWLPSL-------SPDC------------INV 501
Cdd:cd17996 26 ILADEMGLGKTIQTISLITylmeKKKNNGPYLVIVPLSTLSNWVSEFEKWAPSVskivykgTPDVrkklqsqiragkFNV 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 502 VVTG-----KDRLtaglinivsfdLLSKLErqlktpFKVVIIDESHFLKNsrtARCRAAMpVLK---VAKRVILLSGTPA 573
Cdd:cd17996 106 LLTTyeyiiKDKP-----------LLSKIK------WKYMIIDEGHRMKN---AQSKLTQ-TLNtyyHARYRLLLTGTPL 164
|
170 180
....*....|....*....|....*
gi 795612006 574 MSRPAELYTQIIAVKPTFFPQFHAF 598
Cdd:cd17996 165 QNNLPELWALLNFLLPKIFKSCKTF 189
|
|
| DEXHc_SMARCA1_SMARCA5 |
cd17997 |
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ... |
429-598 |
2.67e-16 |
|
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350755 [Multi-domain] Cd Length: 222 Bit Score: 78.90 E-value: 2.67e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 429 FQRAGVNFAIA---KGGRLLLADDMGLGKTIQAICIAAF---YRK-EWPLLVVVPSSVRFTWEQAFLRWLPSLSPdcinV 501
Cdd:cd17997 7 YQIRGLNWLISlfeNGINGILADEMGLGKTLQTISLLGYlkhYKNiNGPHLIIVPKSTLDNWMREFKRWCPSLRV----V 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 502 VVTGKDRLTAGLIN-----------IVSFDLLSKLERQLKT-PFKVVIIDESHFLKN-----SRTARcraampVLKVAKR 564
Cdd:cd17997 83 VLIGDKEERADIIRdvllpgkfdvcITSYEMVIKEKTVLKKfNWRYIIIDEAHRIKNeksklSQIVR------LFNSRNR 156
|
170 180 190
....*....|....*....|....*....|....
gi 795612006 565 vILLSGTPAMSRPAELYTQIIAVKPTFFPQFHAF 598
Cdd:cd17997 157 -LLLTGTPLQNNLHELWALLNFLLPDVFTSSEDF 189
|
|
| DEXHc_CHD3_4_5 |
cd17994 |
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ... |
426-604 |
9.57e-16 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350752 [Multi-domain] Cd Length: 196 Bit Score: 76.71 E-value: 9.57e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 426 LMPFQRAGVN---FAIAKGGRLLLADDMGLGKTIQAICIAAFYRKE----WPLLVVVPSSVRFTWEQAFLRWLPSLSpdc 498
Cdd:cd17994 1 LHPYQLEGLNwlrFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEghskGPFLVSAPLSTIINWEREFEMWAPDFY--- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 499 inVVVTGKDRLTAGLINIVSFD--LLSKLErqlktpFKVVIIDESHFLKNSRTARCRaAMPVLKVAKRViLLSGTPAMSR 576
Cdd:cd17994 78 --VVTYVGDHVLLTSYELISIDqaILGSID------WAVLVVDEAHRLKNNQSKFFR-ILNSYKIGYKL-LLTGTPLQNN 147
|
170 180
....*....|....*....|....*...
gi 795612006 577 PAELYTQIIAVKPTFFPQFHAFGLRYCD 604
Cdd:cd17994 148 LEELFHLLNFLTPERFNNLQGFLEEFAD 175
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
729-812 |
1.18e-15 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 72.63 E-value: 1.18e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 729 DAITQELERKHVQHIRIDGSTSSAEREDLCQQFQlsERHAVAVLSITAANMGLTFSSADLVVFAELFWNPGVLIQAEDRV 808
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFN--NGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRA 78
|
....
gi 795612006 809 HRIG 812
Cdd:smart00490 79 GRAG 82
|
|
| DEXHc_RAD54B |
cd18066 |
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ... |
426-589 |
1.95e-15 |
|
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350824 [Multi-domain] Cd Length: 235 Bit Score: 76.81 E-value: 1.95e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 426 LMPFQRAGVNF--------AIAKGGRLLLADDMGLGKTIQAICIAAFYRKEWP---------LLVVVPSSVRFTWEQAFL 488
Cdd:cd18066 1 LRPHQREGIEFlyecvmgmRVNERFGAILADEMGLGKTLQCISLIWTLLRQGPyggkpvikrALIVTPGSLVKNWKKEFQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 489 RWLPSlspDCINVVVTGKDRLTAGLIN-------IVSFD-LLSKLERQLKTPFKVVIIDESHFLKNSrTARCRAAMPVLK 560
Cdd:cd18066 81 KWLGS---ERIKVFTVDQDHKVEEFIAsplysvlIISYEmLLRSLDQISKLNFDLVICDEGHRLKNT-SIKTTTALTSLS 156
|
170 180
....*....|....*....|....*....
gi 795612006 561 VAKRVIlLSGTPAMSRPAELYTQIIAVKP 589
Cdd:cd18066 157 CERRII-LTGTPIQNDLQEFFALIDFVNP 184
|
|
| DEXHc_ERCC6L2 |
cd18005 |
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ... |
426-571 |
2.66e-15 |
|
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350763 [Multi-domain] Cd Length: 245 Bit Score: 76.65 E-value: 2.66e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 426 LMPFQRAGVNF-----AIAKGGrlLLADDMGLGKTIQAIC-IAAFYRKEW-----------------------PLLVVVP 476
Cdd:cd18005 1 LRDYQREGVEFmydlyKNGRGG--ILGDDMGLGKTVQVIAfLAAVLGKTGtrrdrennrprfkkkppassakkPVLIVAP 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 477 SSVRFTWEQAFLRWlPSLSPDCINVVvtGKD-----RLTAGL--INIVSFDLLSK-LERQLKTPFKVVIIDESHFLKNSR 548
Cdd:cd18005 79 LSVLYNWKDELDTW-GHFEVGVYHGS--RKDdelegRLKAGRleVVVTTYDTLRRcIDSLNSINWSAVIADEAHRIKNPK 155
|
170 180
....*....|....*....|...
gi 795612006 549 TARCRaAMPVLKVaKRVILLSGT 571
Cdd:cd18005 156 SKLTQ-AMKELKC-KVRIGLTGT 176
|
|
| DEXHc_CHD1_2 |
cd17993 |
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ... |
429-572 |
1.02e-14 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350751 [Multi-domain] Cd Length: 218 Bit Score: 74.31 E-value: 1.02e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 429 FQRAGVNFAI---AKGGRLLLADDMGLGKTIQAICIAAFYRKEW----PLLVVVPSSVRFTWEQAFLRWLPSLspdciNV 501
Cdd:cd17993 5 YQLTGLNWLAhswCKGNNGILADEMGLGKTVQTISFLSYLFHSQqqygPFLVVVPLSTMPAWQREFAKWAPDM-----NV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 502 VV-TGkdrltagliNIVSFDLLSKLE------RQLK-----TPFKVVI---------------IDESHFLKNSRTArCRA 554
Cdd:cd17993 80 IVyLG---------DIKSRDTIREYEfyfsqtKKLKfnvllTTYEIILkdkaflgsikwqylaVDEAHRLKNDESL-LYE 149
|
170
....*....|....*...
gi 795612006 555 AMPVLKVAKRvILLSGTP 572
Cdd:cd17993 150 ALKEFKTNNR-LLITGTP 166
|
|
| DEXHc_HELLS_SMARCA6 |
cd18009 |
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ... |
426-598 |
1.85e-14 |
|
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350767 [Multi-domain] Cd Length: 236 Bit Score: 73.96 E-value: 1.85e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 426 LMPFQRAGVNFAIA---KGGRLLLADDMGLGKTIQAICIAAFY--RKEW-PLLVVVPSSVRFTWEQAFLRWLPSlspdcI 499
Cdd:cd18009 4 MRPYQLEGMEWLRMlweNGINGILADEMGLGKTIQTIALLAHLreRGVWgPFLVIAPLSTLPNWVNEFARFTPS-----V 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 500 NVVV---TGKDRLT-AGLIN------------IVSFDLL----SKLERQlktPFKVVIIDESHFLKNSrtaRCR--AAMP 557
Cdd:cd18009 79 PVLLyhgTKEERERlRKKIMkregtlqdfpvvVTSYEIAmrdrKALQHY---AWKYLIVDEGHRLKNL---NCRliQELK 152
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 795612006 558 VLKVAKRvILLSGTPAMSRPAELYTQIIAVKPTFFPQFHAF 598
Cdd:cd18009 153 TFNSDNR-LLLTGTPLQNNLSELWSLLNFLLPDVFDDLSSF 192
|
|
| DEXHc_SMARCA5 |
cd18064 |
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ... |
426-648 |
3.06e-14 |
|
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350822 [Multi-domain] Cd Length: 244 Bit Score: 73.55 E-value: 3.06e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 426 LMPFQRAGVNFAIA---KGGRLLLADDMGLGKTIQAICIAAF---YRK-EWPLLVVVPSSVRFTWEQAFLRWLPSLSPDC 498
Cdd:cd18064 16 LRDYQVRGLNWLISlyeNGINGILADEMGLGKTLQTISLLGYmkhYRNiPGPHMVLVPKSTLHNWMAEFKRWVPTLRAVC 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 499 I-----NVVVTGKDRLTAGL--INIVSFDLLSKLERQLKT-PFKVVIIDESHFLKNSRTaRCRAAMPVLKVAKRvILLSG 570
Cdd:cd18064 96 LigdkdQRAAFVRDVLLPGEwdVCVTSYEMLIKEKSVFKKfNWRYLVIDEAHRIKNEKS-KLSEIVREFKTTNR-LLLTG 173
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 795612006 571 TPAMSRPAELYTQIIAVKPTFFPQFHAFGlRYCDAKrmpwgwDYSGSSNLGELKLLLEEAVMLRRLKSDVLSQLPAKQ 648
Cdd:cd18064 174 TPLQNNLHELWALLNFLLPDVFNSAEDFD-SWFDTN------NCLGDQKLVERLHMVLRPFLLRRIKADVEKSLPPKK 244
|
|
| DEXHc_CHD1L |
cd18006 |
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ... |
426-593 |
3.52e-14 |
|
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350764 [Multi-domain] Cd Length: 216 Bit Score: 72.47 E-value: 3.52e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 426 LMPFQRAGVNFAIAK---GGRLLLADDMGLGKTIQAICIAAFYRK----EWPLLVVVPSSVRFTWEQAFLRWLPSLSpdC 498
Cdd:cd18006 1 LRPYQLEGVNWLLQCraeQHGCILGDEMGLGKTCQTISLLWYLAGrlklLGPFLVLCPLSVLDNWKEELNRFAPDLS--V 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 499 INVVVTGKDR--LTAGLINIVSFD-LLSKLERQLKT-------PFKVVIIDESHFLKNSRTArCRAAMPVLKVAKRvILL 568
Cdd:cd18006 79 ITYMGDKEKRldLQQDIKSTNRFHvLLTTYEICLKDasflksfPWASLVVDEAHRLKNQNSL-LHKTLSEFSVDFR-LLL 156
|
170 180
....*....|....*....|....*
gi 795612006 569 SGTPAMSRPAELYTQIIAVKPTFFP 593
Cdd:cd18006 157 TGTPIQNSLQELYALLSFIEPNVFP 181
|
|
| DEXHc_SMARCA2 |
cd18063 |
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ... |
445-598 |
1.14e-12 |
|
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350821 [Multi-domain] Cd Length: 251 Bit Score: 68.94 E-value: 1.14e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 445 LLADDMGLGKTIQAICIAAFY----RKEWPLLVVVPSSVRFTWEQAFLRWLPSL-------SPDCINVVVTgkdRLTAGL 513
Cdd:cd18063 46 ILADEMGLGKTIQTIALITYLmehkRLNGPYLIIVPLSTLSNWTYEFDKWAPSVvkisykgTPAMRRSLVP---QLRSGK 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 514 INIV--SFDLLSKLERQL-KTPFKVVIIDESHFLKNSRtARCRAAMPVLKVAKRVILLSGTPAMSRPAELYTQIIAVKPT 590
Cdd:cd18063 123 FNVLltTYEYIIKDKHILaKIRWKYMIVDEGHRMKNHH-CKLTQVLNTHYVAPRRILLTGTPLQNKLPELWALLNFLLPT 201
|
....*...
gi 795612006 591 FFPQFHAF 598
Cdd:cd18063 202 IFKSCSTF 209
|
|
| DEXQc_INO80 |
cd18002 |
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ... |
445-598 |
1.68e-12 |
|
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350760 [Multi-domain] Cd Length: 229 Bit Score: 67.91 E-value: 1.68e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 445 LLADDMGLGKTIQAICIAAFYRKE---W-PLLVVVPSSVRFTWEQAFLRWLPSLSpdCINVVVTGKDRLT---------- 510
Cdd:cd18002 23 ILADEMGLGKTVQSIAVLAHLAEEhniWgPFLVIAPASTLHNWQQEISRFVPQFK--VLPYWGNPKDRKVlrkfwdrknl 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 511 ----AGL-INIVSFDLLSKLERQL-KTPFKVVIIDESHFLKNSRTARCRAAMPvLKVAKRvILLSGTPAMSRPAELYTQI 584
Cdd:cd18002 101 ytrdAPFhVVITSYQLVVQDEKYFqRVKWQYMVLDEAQAIKSSSSSRWKTLLS-FHCRNR-LLLTGTPIQNSMAELWALL 178
|
170
....*....|....
gi 795612006 585 IAVKPTFFPQFHAF 598
Cdd:cd18002 179 HFIMPTLFDSHDEF 192
|
|
| DEXHc_SMARCA1 |
cd18065 |
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ... |
417-592 |
1.81e-12 |
|
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350823 [Multi-domain] Cd Length: 233 Bit Score: 68.12 E-value: 1.81e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 417 EVDPKLVSN--LMPFQRAGVNFAIA---KGGRLLLADDMGLGKTIQAICIAAF---YRK-EWPLLVVVPSSVRFTWEQAF 487
Cdd:cd18065 5 EESPSYVKGgtLRDYQVRGLNWMISlyeNGVNGILADEMGLGKTLQTIALLGYlkhYRNiPGPHMVLVPKSTLHNWMNEF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 488 LRWLPSLSPDCInvvvTGKDRLTAGLIN-----------IVSFDLLSKLERQLKT-PFKVVIIDESHFLKNSRTaRCRAA 555
Cdd:cd18065 85 KRWVPSLRAVCL----IGDKDARAAFIRdvmmpgewdvcVTSYEMVIKEKSVFKKfNWRYLVIDEAHRIKNEKS-KLSEI 159
|
170 180 190
....*....|....*....|....*....|....*..
gi 795612006 556 MPVLKVAKRvILLSGTPAMSRPAELYTQIIAVKPTFF 592
Cdd:cd18065 160 VREFKTTNR-LLLTGTPLQNNLHELWALLNFLLPDVF 195
|
|
| DEXHc_RAD54A |
cd18067 |
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ... |
426-602 |
1.97e-12 |
|
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350825 [Multi-domain] Cd Length: 243 Bit Score: 68.27 E-value: 1.97e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 426 LMPFQRAGVNF--AIAKGGRL------LLADDMGLGKTIQaiCIAAFyrkeWPLL--------------VVVPSSVRFTW 483
Cdd:cd18067 1 LRPHQREGVKFlyRCVTGRRIrgshgcIMADEMGLGKTLQ--CITLM----WTLLrqspqckpeidkaiVVSPSSLVKNW 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 484 EQAFLRWL-PSLSPdcinVVVTGK-----DRLTAGLIN-----------IVSFDLL-SKLERQLKTPFKVVIIDESHFLK 545
Cdd:cd18067 75 ANELGKWLgGRLQP----LAIDGGskkeiDRKLVQWASqqgrrvstpvlIISYETFrLHVEVLQKGEVGLVICDEGHRLK 150
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 795612006 546 NSRTaRCRAAMPVLKVAKRVIlLSGTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRY 602
Cdd:cd18067 151 NSDN-QTYQALDSLNTQRRVL-LSGTPIQNDLSEYFSLVNFVNPGILGTAAEFKKNF 205
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
426-810 |
2.01e-12 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 70.82 E-value: 2.01e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 426 LMPFQRAGVNFAIA----KGGRLLLADDMGLGKTIQAICIAAFYRKEWPLLVVVPS-SVRFTWEQAFLRWLPslspdciN 500
Cdd:COG1061 81 LRPYQQEALEALLAalerGGGRGLVVAPTGTGKTVLALALAAELLRGKRVLVLVPRrELLEQWAEELRRFLG-------D 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 501 VVVTGKDRLTAGLINIVSFDLLSKLE--RQLKTPFKVVIIDESHFLKNSRTARCRAAMPvlkvAKRVILLSGTP----AM 574
Cdd:COG1061 154 PLAGGGKKDSDAPITVATYQSLARRAhlDELGDRFGLVIIDEAHHAGAPSYRRILEAFP----AAYRLGLTATPfrsdGR 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 575 SRPAELYTQIIavkptffpqfhaFGLRYCDAkrmpwgwdysgssnlgelkllleeavmlrrLKSDVLSQlpakqrkivvi 654
Cdd:COG1061 230 EILLFLFDGIV------------YEYSLKEA------------------------------IEDGYLAP----------- 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 655 apgrinARTRAALDAAAKEMATTDKTKQQQKDALIlffnRTAEAKIPSVIEYILDllESGREKFLVFAHHKVVLDAITQE 734
Cdd:COG1061 257 ------PEYYGIRVDLTDERAEYDALSERLREALA----ADAERKDKILRELLRE--HPDDRKTLVFCSSVDHAEALAEL 324
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 795612006 735 LERKHVQHIRIDGSTSSAEREDLCQQFqlSERHAVAVLSITAANMGLTFSSADLVVFAELFWNPGVLIQAEDRVHR 810
Cdd:COG1061 325 LNEAGIRAAVVTGDTPKKEREEILEAF--RDGELRILVTVDVLNEGVDVPRLDVAILLRPTGSPREFIQRLGRGLR 398
|
|
| DEXHc_CHD6 |
cd18058 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ... |
445-606 |
3.08e-12 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350816 [Multi-domain] Cd Length: 222 Bit Score: 66.99 E-value: 3.08e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 445 LLADDMGLGKTIQAICIAA--FYRK-EWPLLVVVPSSVRFTWEQAFLRWLPslspdcINVVVTGKDRLTAGLIN------ 515
Cdd:cd18058 23 ILADEMGLGKTIQSITFLSeiFLMGiRGPFLIIAPLSTITNWEREFRTWTE------MNAIVYHGSQISRQMIQqyemyy 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 516 -----------------IVSFDL-LSKLERQLKTPFKVVIIDESHFLKNsRTARCRAAMPVLKVAKRViLLSGTPAMSRP 577
Cdd:cd18058 97 rdeqgnplsgifkfqvvITTFEMiLADCPELKKINWSCVIIDEAHRLKN-RNCKLLEGLKLMALEHKV-LLTGTPLQNSV 174
|
170 180
....*....|....*....|....*....
gi 795612006 578 AELYTQIIAVKPTFFPQFHAFGLRYCDAK 606
Cdd:cd18058 175 EELFSLLNFLEPSQFPSETTFLEEFGDLK 203
|
|
| DEXHc_SMARCA4 |
cd18062 |
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ... |
445-598 |
3.72e-12 |
|
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350820 [Multi-domain] Cd Length: 251 Bit Score: 67.38 E-value: 3.72e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 445 LLADDMGLGKTIQAICIAA----FYRKEWPLLVVVPSSVRFTWEQAFLRWLPSL-------SPDCINVVVTgkdRLTAGL 513
Cdd:cd18062 46 ILADEMGLGKTIQTIALITylmeHKRINGPFLIIVPLSTLSNWVYEFDKWAPSVvkvsykgSPAARRAFVP---QLRSGK 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 514 INIV--SFDLLSKLERQL-KTPFKVVIIDESHFLKNSRtARCRAAMPVLKVAKRVILLSGTPAMSRPAELYTQIIAVKPT 590
Cdd:cd18062 123 FNVLltTYEYIIKDKQILaKIRWKYMIVDEGHRMKNHH-CKLTQVLNTHYVAPRRLLLTGTPLQNKLPELWALLNFLLPT 201
|
....*...
gi 795612006 591 FFPQFHAF 598
Cdd:cd18062 202 IFKSCSTF 209
|
|
| DEXHc_CHD2 |
cd18054 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ... |
426-598 |
7.88e-12 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350812 [Multi-domain] Cd Length: 237 Bit Score: 66.18 E-value: 7.88e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 426 LMPFQRAGVNF---AIAKGGRLLLADDMGLGKTIQAICIAAF----YRKEWPLLVVVPSSVRFTWEQAFLRWLPSlspdc 498
Cdd:cd18054 21 LRDYQLEGLNWlahSWCKNNSVILADEMGLGKTIQTISFLSYlfhqHQLYGPFLLVVPLSTLTSWQREFEIWAPE----- 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 499 INVVVTGKDRLTAGLINivSFDLLSKLERQLK-----TPFKVVI---------------IDESHFLKNSRTARCRAAMPV 558
Cdd:cd18054 96 INVVVYIGDLMSRNTIR--EYEWIHSQTKRLKfnaliTTYEILLkdktvlgsinwaflgVDEAHRLKNDDSLLYKTLIDF 173
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 795612006 559 LKVAKrvILLSGTPAMSRPAELYTQIIAVKPTFFPQFHAF 598
Cdd:cd18054 174 KSNHR--LLITGTPLQNSLKELWSLLHFIMPEKFEFWEDF 211
|
|
| DEXHc_ERCC6 |
cd18000 |
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ... |
426-591 |
8.65e-12 |
|
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350758 [Multi-domain] Cd Length: 193 Bit Score: 65.04 E-value: 8.65e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 426 LMPFQRAGVNFAIAKGGRL---LLADDMGLGKTIQAIC--IAAFYRKEW--PLLVVVPSSVRFTWEQAFLRWLPSLspdc 498
Cdd:cd18000 1 LFKYQQTGVQWLWELHCQRvggILGDEMGLGKTIQIIAflAALHHSKLGlgPSLIVCPATVLKQWVKEFHRWWPPF---- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 499 iNVVV-------TGKDR---------------LTAGLINIVSFDLLSKLERQL-KTPFKVVIIDESHFLKNSRtARCRAA 555
Cdd:cd18000 77 -RVVVlhssgsgTGSEEklgsierksqlirkvVGDGGILITTYEGFRKHKDLLlNHNWQYVILDEGHKIRNPD-AEITLA 154
|
170 180 190
....*....|....*....|....*....|....*.
gi 795612006 556 MPVLKVAKRVIlLSGTPAMSRPAELYTQIIAVKPTF 591
Cdd:cd18000 155 CKQLRTPHRLI-LSGTPIQNNLKELWSLFDFVFPPY 189
|
|
| DEXHc_CHD7 |
cd18059 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ... |
426-606 |
1.12e-11 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350817 [Multi-domain] Cd Length: 222 Bit Score: 65.44 E-value: 1.12e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 426 LMPFQRAGVN---FAIAKGGRLLLADDMGLGKTIQAIC-IAAFYRK--EWPLLVVVPSSVRFTWEQAFLRWLPslspdcI 499
Cdd:cd18059 1 LREYQLEGVNwllFNWYNTRNCILADEMGLGKTIQSITfLYEIYLKgiHGPFLVIAPLSTIPNWEREFRTWTE------L 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 500 NVVVTGKDRLTAGLIN-----------------------IVSFDL-LSKLERQLKTPFKVVIIDESHFLKNsRTARCRAA 555
Cdd:cd18059 75 NVVVYHGSQASRRTIQlyemyfkdpqgrvikgsykfhaiITTFEMiLTDCPELRNIPWRCVVIDEAHRLKN-RNCKLLEG 153
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 795612006 556 MPVLKVAKRViLLSGTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRYCDAK 606
Cdd:cd18059 154 LKMMDLEHKV-LLTGTPLQNTVEELFSLLHFLEPSRFPSETTFMQEFGDLK 203
|
|
| DEXHc_CHD8 |
cd18060 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ... |
426-606 |
1.62e-11 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350818 [Multi-domain] Cd Length: 222 Bit Score: 65.07 E-value: 1.62e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 426 LMPFQRAGVN---FAIAKGGRLLLADDMGLGKTIQAIC-IAAFYRK--EWPLLVVVPSSVRFTWEQAFLRWLPslspdcI 499
Cdd:cd18060 1 LREYQLEGVNwllFNWYNRQNCILADEMGLGKTIQSIAfLQEVYNVgiHGPFLVIAPLSTITNWEREFNTWTE------M 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 500 NVVV-------------------TGKDRLTAGLIN----IVSFDL-LSKLERQLKTPFKVVIIDESHFLKNsRTARCRAA 555
Cdd:cd18060 75 NTIVyhgslasrqmiqqyemyckDSRGRLIPGAYKfdalITTFEMiLSDCPELREIEWRCVIIDEAHRLKN-RNCKLLDS 153
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 795612006 556 MPVLKVAKRViLLSGTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRYCDAK 606
Cdd:cd18060 154 LKHMDLEHKV-LLTGTPLQNTVEELFSLLHFLEPSQFPSESEFLKDFGDLK 203
|
|
| DEXHc_CHD5 |
cd18057 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ... |
426-607 |
4.35e-11 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350815 [Multi-domain] Cd Length: 232 Bit Score: 63.93 E-value: 4.35e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 426 LMPFQRAGVN---FAIAKGGRLLLADDMGLGKTIQAIC-IAAFYRK---EWPLLVVVPSSVRFTWEQAFLRWlpslSPDC 498
Cdd:cd18057 1 LHPYQLEGLNwlrFSWAQGTDTILADEMGLGKTVQTIVfLYSLYKEghsKGPYLVSAPLSTIINWEREFEMW----APDF 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 499 INVVVTGkDRLTAGLI--NIVSFD----------LLSKLERQLK-----TPFKVV---------------IIDESHFLKN 546
Cdd:cd18057 77 YVVTYTG-DKESRSVIreNEFSFEdnairsgkkvFRMKKEAQIKfhvllTSYELItidqailgsiewaclVVDEAHRLKN 155
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 795612006 547 SRTARCRaAMPVLKVAKRvILLSGTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRYCDAKR 607
Cdd:cd18057 156 NQSKFFR-VLNSYKIDYK-LLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADISK 214
|
|
| DEXHc_CHD4 |
cd18056 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ... |
426-607 |
6.44e-11 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350814 [Multi-domain] Cd Length: 232 Bit Score: 63.55 E-value: 6.44e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 426 LMPFQRAGVN---FAIAKGGRLLLADDMGLGKTIQ-AICIAAFYRK---EWPLLVVVPSSVRFTWEQAFLRWLPSLSpdc 498
Cdd:cd18056 1 LHPYQLEGLNwlrFSWAQGTDTILADEMGLGKTVQtAVFLYSLYKEghsKGPFLVSAPLSTIINWEREFEMWAPDMY--- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 499 inVVVTGKDRLTAGLI--NIVSFD--------LLSKLERQLKTPFKV----------------------VIIDESHFLKN 546
Cdd:cd18056 78 --VVTYVGDKDSRAIIreNEFSFEdnairggkKASRMKKEASVKFHVlltsyelitidmailgsidwacLIVDEAHRLKN 155
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 795612006 547 SRTARCRaampVLK--VAKRVILLSGTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRYCDAKR 607
Cdd:cd18056 156 NQSKFFR----VLNgySLQHKLLLTGTPLQNNLEELFHLLNFLTPERFHNLEGFLEEFADIAK 214
|
|
| DEXHc_CHD3 |
cd18055 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ... |
429-607 |
2.45e-10 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350813 [Multi-domain] Cd Length: 232 Bit Score: 61.57 E-value: 2.45e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 429 FQRAGVN---FAIAKGGRLLLADDMGLGKTIQAICIAAFYRKE----WPLLVVVPSSVRFTWEQAFLRWlpslSPDCINV 501
Cdd:cd18055 4 YQLEGLNwlrFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEghtkGPFLVSAPLSTIINWEREFQMW----APDFYVV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 502 VVTG-KDRLTAGLINIVSFDLLS--------KLERQLKTPFKV----------------------VIIDESHFLKNSRTA 550
Cdd:cd18055 80 TYTGdKDSRAIIRENEFSFDDNAvkggkkafKMKREAQVKFHVlltsyelvtidqaalgsirwacLVVDEAHRLKNNQSK 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 795612006 551 RCRaAMPVLKVAKRvILLSGTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRYCDAKR 607
Cdd:cd18055 160 FFR-VLNGYKIDHK-LLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADISK 214
|
|
| DEXHc_CHD9 |
cd18061 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ... |
426-606 |
8.48e-10 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350819 [Multi-domain] Cd Length: 222 Bit Score: 60.02 E-value: 8.48e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 426 LMPFQRAGVN---FAIAKGGRLLLADDMGLGKTIQAIC-IAAFYRK--EWPLLVVVPSSVRFTWEQAFLRWLPslspdcI 499
Cdd:cd18061 1 LREYQLEGLNwllFNWYNRRNCILADEMGLGKTIQSITfLYEILLTgiRGPFLIIAPLSTIANWEREFRTWTD------L 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 500 NVVVTGKDRLTAGLIN-----------------------IVSFDLLSKLERQLKT-PFKVVIIDESHFLKNsRTARCRAA 555
Cdd:cd18061 75 NVVVYHGSLISRQMIQqyemyfrdsqgriirgayrfqaiITTFEMILGGCPELNAiDWRCVIIDEAHRLKN-KNCKLLEG 153
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 795612006 556 MPVLKVAKRViLLSGTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRYCDAK 606
Cdd:cd18061 154 LKLMNLEHKV-LLTGTPLQNTVEELFSLLHFLEPLRFPSESTFMQEFGDLK 203
|
|
| DEXHc_ATRX |
cd18068 |
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ... |
426-602 |
1.01e-09 |
|
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350826 [Multi-domain] Cd Length: 246 Bit Score: 59.90 E-value: 1.01e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 426 LMPFQRAGVNFAI------------AKGGRLLLADDMGLGKTIQAIC----------IAAFYRkewpLLVVVPSSVRFTW 483
Cdd:cd18068 1 LKPHQVDGVQFMWdccceslkktkkSPGSGCILAHCMGLGKTLQVVTflhtvllcekLENFSR----VLVVCPLNTVLNW 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 484 EQAFLRWLPSLS-PDCINV-----VVTGKDRLTA-------GLINIVSFDLLS--------KLERQLKTPFK-------- 534
Cdd:cd18068 77 LNEFEKWQEGLKdEEKIEVnelatYKRPQERSYKlqrwqeeGGVMIIGYDMYRilaqernvKSREKLKEIFNkalvdpgp 156
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 795612006 535 -VVIIDESHFLKNSRTARCRAAMPVLkvAKRVILLSGTPAMSRPAELYTQIIAVKPTFFPQFHAFGLRY 602
Cdd:cd18068 157 dFVVCDEGHILKNEASAVSKAMNSIR--TKRRIVLTGTPLQNNLIEYHCMVNFVKPNLLGTIKEFRNRF 223
|
|
| DEXHc_HLTF1_SMARC3 |
cd18071 |
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ... |
441-582 |
5.85e-09 |
|
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350829 [Multi-domain] Cd Length: 239 Bit Score: 57.86 E-value: 5.85e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 441 GGrlLLADDMGLGKTIQAICIAAFYrkewPLLVVVPSSVRFTWEQAFLRwlpSLSPDCINVVVT-GKDR-LTAGLI---- 514
Cdd:cd18071 50 GG--ILADDMGLGKTLTTISLILAN----FTLIVCPLSVLSNWETQFEE---HVKPGQLKVYTYhGGERnRDPKLLskyd 120
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 795612006 515 ------NIVSFDLLSKLERQLKT-PFKVVIIDESHFLKNSRTARCRAampVLKV-AKRVILLSGTPAMSRPAELYT 582
Cdd:cd18071 121 ivlttyNTLASDFGAKGDSPLHTiNWLRVVLDEGHQIRNPNAQQTKA---VLNLsSERRWVLTGTPIQNSPKDLGS 193
|
|
| DEXHc_CHD1 |
cd18053 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ... |
426-598 |
4.16e-08 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350811 [Multi-domain] Cd Length: 237 Bit Score: 55.06 E-value: 4.16e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 426 LMPFQRAGVNF---AIAKGGRLLLADDMGLGKTIQAICIAAFYRKEW----PLLVVVPSSVRFTWEQAFLRWLPSLspdc 498
Cdd:cd18053 21 LRDYQLNGLNWlahSWCKGNSCILADEMGLGKTIQTISFLNYLFHEHqlygPFLLVVPLSTLTSWQREIQTWAPQM---- 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 499 iNVVVTGKDRLTAGLINI----------VSFD-LLSKLERQLK-------TPFKVVIIDESHFLKNSRTARCRaAMPVLK 560
Cdd:cd18053 97 -NAVVYLGDINSRNMIRThewmhpqtkrLKFNiLLTTYEILLKdksflggLNWAFIGVDEAHRLKNDDSLLYK-TLIDFK 174
|
170 180 190
....*....|....*....|....*....|....*...
gi 795612006 561 VAKRvILLSGTPAMSRPAELYTQIIAVKPTFFPQFHAF 598
Cdd:cd18053 175 SNHR-LLITGTPLQNSLKELWSLLHFIMPEKFSSWEDF 211
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
426-572 |
6.29e-08 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 52.69 E-value: 6.29e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 426 LMPFQRAGVN--FAIAKGGRLLLADDMGLGKTIQAICIAAfYRKEWPLLVVVPS-SVRFTWEQAFLRWLPSLS------- 495
Cdd:cd17926 1 LRPYQEEALEawLAHKNNRRGILVLPTGSGKTLTALALIA-YLKELRTLIVVPTdALLDQWKERFEDFLGDSSigliggg 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 496 ----PDCINVVVTgkdrltagLINIVSFDLlsKLERQLKTPFKVVIIDESHFLkNSRTARcraAMPVLKVAKRVILLSGT 571
Cdd:cd17926 80 kkkdFDDANVVVA--------TYQSLSNLA--EEEKDLFDQFGLLIVDEAHHL-PAKTFS---EILKELNAKYRLGLTAT 145
|
.
gi 795612006 572 P 572
Cdd:cd17926 146 P 146
|
|
| DEXHc_ARIP4 |
cd18069 |
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ... |
436-591 |
4.73e-07 |
|
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350827 [Multi-domain] Cd Length: 227 Bit Score: 51.74 E-value: 4.73e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 436 FAIAKGGRLLLADDMGLGKTIQAIC-IAAFYR--KEWPLLVVVPSSVRFTWEQAFLRWLPSLS------PDCINVVVTGK 506
Cdd:cd18069 23 YKGSSGFGCILAHSMGLGKTLQVISfLDVLLRhtGAKTVLAIVPVNTLQNWLSEFNKWLPPPEalpnvrPRPFKVFILND 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 507 DRLT----AGLIN---------IVSFDLLsklerQLKTPFKVVIIDESHFLKNSrTARCRAAMPVLKvAKRVILLSGTPA 573
Cdd:cd18069 103 EHKTtaarAKVIEdwvkdggvlLMGYEMF-----RLRPGPDVVICDEGHRIKNC-HASTSQALKNIR-SRRRIVLTGYPL 175
|
170
....*....|....*...
gi 795612006 574 MSRPAELYTQIIAVKPTF 591
Cdd:cd18069 176 QNNLIEYWCMVDFVRPDF 193
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
441-571 |
5.25e-05 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 44.32 E-value: 5.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 441 GGRLLLADDMGLGKTIQA--ICIAAFYRKEWPLLVVVP-SSVRFTWEQAFLRWLPSLSPDCINV------VVTGKDRLTA 511
Cdd:cd00046 1 GENVLITAPTGSGKTLAAllAALLLLLKKGKKVLVLVPtKALALQTAERLRELFGPGIRVAVLVggssaeEREKNKLGDA 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 795612006 512 GLInIVS----FDLLSKLERQLKTPFKVVIIDESH-FLKNSRTAR------CRAAMPVLkvakRVILLSGT 571
Cdd:cd00046 81 DII-IATpdmlLNLLLREDRLFLKDLKLIIVDEAHaLLIDSRGALildlavRKAGLKNA----QVILLSAT 146
|
|
| DEXQc_SHPRH |
cd18070 |
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously ... |
426-518 |
6.25e-05 |
|
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously expressed protein that contains motifs characteristic of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 and is involved in DNA repair. SHPRH is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350828 [Multi-domain] Cd Length: 257 Bit Score: 45.80 E-value: 6.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 426 LMPFQRAGVNFAIAKGGrlLLADDMGLGKTIQAI-CIAAFYRKEWPLlvvvpssvrftwEQAFLRWLPSlspDCINVVVT 504
Cdd:cd18070 1 LLPYQRRAVNWMLVPGG--ILADEMGLGKTVEVLaLILLHPRPDNDL------------DAADDDSDEM---VCCPDCLV 63
|
90
....*....|....
gi 795612006 505 GKDRLTAGLINIVS 518
Cdd:cd18070 64 AETPVSSKATLIVC 77
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
451-542 |
5.69e-04 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 41.50 E-value: 5.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 451 GLGKTIQAICIAAFYRKEWPL---LVVVPS-SVRFTWEQAFLRWLPSLSPDCINVVVTGKDRLTAG----LINIVSFDLL 522
Cdd:pfam04851 33 GSGKTLTAAKLIARLFKKGPIkkvLFLVPRkDLLEQALEEFKKFLPNYVEIGEIISGDKKDESVDDnkivVTTIQSLYKA 112
|
90 100
....*....|....*....|..
gi 795612006 523 SKLERQLKTP--FKVVIIDESH 542
Cdd:pfam04851 113 LELASLELLPdfFDVIIIDEAH 134
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
699-895 |
1.85e-03 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 42.17 E-value: 1.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 699 KIPSVIEYILD-LLESGREKFLVFAHHKVVLDAITQELERKHVQHIRIDGSTSSAEREDLCQQFQL-------SERHAVA 770
Cdd:PRK13766 348 KLEKLREIVKEqLGKNPDSRIIVFTQYRDTAEKIVDLLEKEGIKAVRFVGQASKDGDKGMSQKEQIeildkfrAGEFNVL 427
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 771 VlSITAANMGLTFSSADLVVFAElfwnPgvlIQAEDR-VHRIGQT--SSVG-IHYLVAKGTADD-YLWPLI------QEK 839
Cdd:PRK13766 428 V-STSVAEEGLDIPSVDLVIFYE----P---VPSEIRsIQRKGRTgrQEEGrVVVLIAKGTRDEaYYWSSRrkekkmKEE 499
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 795612006 840 IKVLAEAgLSETNFSEMTESTDYLYKDPKQQKIYDlFQKSFEKEGSDMELLEAAET 895
Cdd:PRK13766 500 LKNLKGI-LNKKLQELDEEQKGEEEEKDEQLSLDD-FVKSKGKEEEEEEEKEEKDK 553
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
770-819 |
3.10e-03 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 37.30 E-value: 3.10e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 795612006 770 AVLSITAANMGLTFSSADLVVFAELFWNPGVLIQAEDRVHRIGQTSSVGI 819
Cdd:cd18785 25 ILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKDEGEVI 74
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
717-846 |
3.53e-03 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 40.91 E-value: 3.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 795612006 717 KFLVFAHHKVVLDAITQELERKHVQHIRIDGSTSSAEREDLCQQFQlSERHAVAVLSITAANmGLTFSSADLVVFAELfw 796
Cdd:PTZ00110 379 KILIFVETKKGADFLTKELRLDGWPALCIHGDKKQEERTWVLNEFK-TGKSPIMIATDVASR-GLDVKDVKYVINFDF-- 454
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 795612006 797 nPGvliQAEDRVHRIGQTSSVGihylvAKGTADDYLWP----LIQEKIKVLAEA 846
Cdd:PTZ00110 455 -PN---QIEDYVHRIGRTGRAG-----AKGASYTFLTPdkyrLARDLVKVLREA 499
|
|
| |
