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Conserved domains on  [gi|929516406|ref|XP_014118602|]
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PREDICTED: Niemann-Pick C1-like protein 1, partial [Pseudopodoces humilis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
2A060601 super family cl36767
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
 1-103 7.68e-23

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00917:

Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 91.51  E-value: 7.68e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929516406     1 DSYLVQFFLDLNQYLAVGVPTYFVTTGGFDFSSPNGTNAICSSAGCDDDSLTQtiqmatRFPNVSYLAIPATSWVDDFLD 80
Cdd:TIGR00917  836 DSYLQIYFASLTPLLEVGPPFYIVIKGDYNYTDFESQNKLCTMGGCDKDSIVN------VFNNLSYIAKPASSWLDDYLV 909

                           90       100
                   ....*....|....*....|...
gi 929516406    81 WLNPMGPCCRVYeceELQGEFCP 103
Cdd:TIGR00917  910 WLSPQASCCCRK---FTNGTFCN 929
 
Name Accession Description Interval E-value
2A060601 TIGR00917
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
 1-103 7.68e-23

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 91.51  E-value: 7.68e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929516406     1 DSYLVQFFLDLNQYLAVGVPTYFVTTGGFDFSSPNGTNAICSSAGCDDDSLTQtiqmatRFPNVSYLAIPATSWVDDFLD 80
Cdd:TIGR00917  836 DSYLQIYFASLTPLLEVGPPFYIVIKGDYNYTDFESQNKLCTMGGCDKDSIVN------VFNNLSYIAKPASSWLDDYLV 909

                           90       100
                   ....*....|....*....|...
gi 929516406    81 WLNPMGPCCRVYeceELQGEFCP 103
Cdd:TIGR00917  910 WLSPQASCCCRK---FTNGTFCN 929
 
Name Accession Description Interval E-value
2A060601 TIGR00917
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
 1-103 7.68e-23

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 91.51  E-value: 7.68e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929516406     1 DSYLVQFFLDLNQYLAVGVPTYFVTTGGFDFSSPNGTNAICSSAGCDDDSLTQtiqmatRFPNVSYLAIPATSWVDDFLD 80
Cdd:TIGR00917  836 DSYLQIYFASLTPLLEVGPPFYIVIKGDYNYTDFESQNKLCTMGGCDKDSIVN------VFNNLSYIAKPASSWLDDYLV 909

                           90       100
                   ....*....|....*....|...
gi 929516406    81 WLNPMGPCCRVYeceELQGEFCP 103
Cdd:TIGR00917  910 WLSPQASCCCRK---FTNGTFCN 929
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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