|
Name |
Accession |
Description |
Interval |
E-value |
| DEXHc_TTF2 |
cd18072 |
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ... |
570-820 |
1.96e-148 |
|
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350830 [Multi-domain] Cd Length: 241 Bit Score: 444.62 E-value: 1.96e-148
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 570 LLLHQKQALAWLLWRESQKPQGGILADDMGLGKTLTMIALILTQKNQEKKEEKEKSTALT-WLSKDDSCDFTSHGTLIIC 648
Cdd:cd18072 1 LLLHQKQALAWLLWRERQKPRGGILADDMGLGKTLTMIALILAQKNTQNRKEEEKEKALTeWESKKDSTLVPSAGTLVVC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 649 PASLIHHWKNEVEKRVNSNKLRVYLYHGPNRDSRARVLSTYDIVITTYSLVAKEIPTNKQEaeipganlnveGTSTPLLR 728
Cdd:cd18072 81 PASLVHQWKNEVESRVASNKLRVCLYHGPNRERIGEVLRDYDIVITTYSLVAKEIPTYKEE-----------SRSSPLFR 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 729 IAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPFDEFNLWRSQVDNGSKKGGER 808
Cdd:cd18072 150 IAWARIILDEAHNIKNPKVQASIAVCKLRAHARWALTGTPIQNNLLDMYSLLKFLRCSPFDDLKVWKKQVDNKSRKGGER 229
|
250
....*....|..
gi 1034562578 809 LSILTKSLLLRR 820
Cdd:cd18072 230 LNILTKSLLLRR 241
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
559-1142 |
8.70e-127 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 404.22 E-value: 8.70e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 559 VAEDPAGLKVPLLLHQKQALAWLLWRESQKPqGGILADDMGLGKTLTMIALILTQKNQEKKEEkekstaltwlskddscd 638
Cdd:COG0553 231 LESLPAGLKATLRPYQLEGAAWLLFLRRLGL-GGLLADDMGLGKTIQALALLLELKERGLARP----------------- 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 639 ftshgTLIICPASLIHHWKNEVEKRVNSnkLRVYLYHGP-NRDSRARVLSTYDIVITTYSLVAKEIPTnkqeaeipganl 717
Cdd:COG0553 293 -----VLIVAPTSLVGNWQRELAKFAPG--LRVLVLDGTrERAKGANPFEDADLVITSYGLLRRDIEL------------ 353
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 718 nvegtstpLLRIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFL---RCSPFDEFN-L 793
Cdd:COG0553 354 --------LAAVDWDLVILDEAQHIKNPATKRAKAVRALKARHRLALTGTPVENRLEELWSLLDFLnpgLLGSLKAFReR 425
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 794 WRSQVDNGSKKGGERLSILTKSLLLRRTKDQLdstgrpLVILPQRKFQLHHLKLSEDEETVYNvffarsrsALQSYLKRH 873
Cdd:COG0553 426 FARPIEKGDEEALERLRRLLRPFLLRRTKEDV------LKDLPEKTEETLYVELTPEQRALYE--------AVLEYLRRE 491
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 874 esrgnqsgrspnnpfsrvalefgseeprhsEAADSPRSSTVHILSQLLRLRQCCCHLSLLksaldpmelkgeglvlsLEE 953
Cdd:COG0553 492 ------------------------------LEGAEGIRRRGLILAALTRLRQICSHPALL-----------------LEE 524
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 954 QLSaltlSELRDSepsstvslngtffKMELFegmrestkissllaeLEAIQRNSASQKSVIV-SQWTNMLKVVALHLKKH 1032
Cdd:COG0553 525 GAE----LSGRSA-------------KLEAL---------------LELLEELLAEGEKVLVfSQFTDTLDLLEERLEER 572
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 1033 GLTYATIDGSVNPKQRMDLVEAFNHSRGPQVMLISLLAGGVGLNLTGGNHLFLLDMHWNPSLEDQACDRIYRVGQQKDVV 1112
Cdd:COG0553 573 GIEYAYLHGGTSAEERDELVDRFQEGPEAPVFLISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQ 652
|
570 580 590
....*....|....*....|....*....|
gi 1034562578 1113 IHRFVCEGTVEEKILQLQEKKKDLAKQVLS 1142
Cdd:COG0553 653 VYKLVAEGTIEEKILELLEEKRALAESVLG 682
|
|
| DEXDc_SHPRH-like |
cd18008 |
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ... |
570-820 |
3.90e-103 |
|
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350766 [Multi-domain] Cd Length: 241 Bit Score: 325.01 E-value: 3.90e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 570 LLLHQKQALAWLLWResqkpqGGILADDMGLGKTLTMIALILTQKNQEKKEEKEKSTaltwLSKDDSCDFTSHGTLIICP 649
Cdd:cd18008 1 LLPYQKQGLAWMLPR------GGILADEMGLGKTIQALALILATRPQDPKIPEELEE----NSSDPKKLYLSKTTLIVVP 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 650 ASLIHHWKNEVEKRVNSNKLRVYLYHGPNRDSRARVLSTYDIVITTYSLVAKEIPTNKQeaeiPGANLNVEGTSTPLLRI 729
Cdd:cd18008 71 LSLLSQWKDEIEKHTKPGSLKVYVYHGSKRIKSIEELSDYDIVITTYGTLASEFPKNKK----GGGRDSKEKEASPLHRI 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 730 AWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPFDEFNLWRSQV----DNGSKKG 805
Cdd:cd18008 147 RWYRVILDEAHNIKNRSTKTSRAVCALKAERRWCLTGTPIQNSLDDLYSLLRFLRVEPFGDYPWFNSDIskpfSKNDRKA 226
|
250
....*....|....*
gi 1034562578 806 GERLSILTKSLLLRR 820
Cdd:cd18008 227 LERLQALLKPILLRR 241
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
573-933 |
4.45e-74 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 247.60 E-value: 4.45e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 573 HQKQALAWLLWRESQKPQGGILADDMGLGKTLTMIALILTQKNQEKkeekekstaltwlskddscdFTSHGTLIICPASL 652
Cdd:pfam00176 1 YQIEGVNWMLSLENNLGRGGILADEMGLGKTLQTISLLLYLKHVDK--------------------NWGGPTLIVVPLSL 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 653 IHHWKNEVEKRVNSNKLRVYLYHGPNRDSRA-----RVLSTYDIVITTYSLVAKEiptnkqeaeipganlnvegtSTPLL 727
Cdd:pfam00176 61 LHNWMNEFERWVSPPALRVVVLHGNKRPQERwkndpNFLADFDVVITTYETLRKH--------------------KELLK 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 728 RIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPFDEFNLWRSQVDN-----GS 802
Cdd:pfam00176 121 KVHWHRIVLDEGHRLKNSKSKLSKALKSLKTRNRWILTGTPLQNNLEELWALLNFLRPGPFGSLSTFRNWFDRpiergGG 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 803 KKGGERLSILTKSLLLRRTKDQLDSTgrplviLPQRKFQLHHLKLSEDEETVYNVFFarsrsalqsylkrHESRGNQsgr 882
Cdd:pfam00176 201 KKGVSRLHKLLKPFLLRRTKKDVEKS------LPPKVEYILFCRLSKLQRKLYQTFL-------------LKKDLNA--- 258
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1034562578 883 spnnpfsrVALEFGSEEPRHSeaadsprsstvhILSQLLRLRQCCCHLSLL 933
Cdd:pfam00176 259 --------IKTGEGGREIKAS------------LLNILMRLRKICNHPGLI 289
|
|
| DEXHc_HLTF1_SMARC3 |
cd18071 |
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ... |
570-820 |
2.52e-64 |
|
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350829 [Multi-domain] Cd Length: 239 Bit Score: 218.11 E-value: 2.52e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 570 LLLHQKQALAWLLWRE-----------------------SQK--PQ---GGILADDMGLGKTLTMIALILTQKnqekkee 621
Cdd:cd18071 1 LLPHQKQALAWMVSREnsqdlppfweeavglflntitnfSQKkrPElvrGGILADDMGLGKTLTTISLILANF------- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 622 kekstaltwlskddscdftshgTLIICPASLIHHWKNEVEKRVNSNKLRVYLYHGPNRDSRARVLSTYDIVITTYSLVAK 701
Cdd:cd18071 74 ----------------------TLIVCPLSVLSNWETQFEEHVKPGQLKVYTYHGGERNRDPKLLSKYDIVLTTYNTLAS 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 702 EiptnkqeaeipganlnvEGT--STPLLRIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSL 779
Cdd:cd18071 132 D-----------------FGAkgDSPLHTINWLRVVLDEGHQIRNPNAQQTKAVLNLSSERRWVLTGTPIQNSPKDLGSL 194
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 1034562578 780 LKFLRCSPFDEFNLWRS----QVDNGSKKGGERLSILTKSLLLRR 820
Cdd:cd18071 195 LSFLHLKPFSNPEYWRRliqrPLTMGDPTGLKRLQVLMKQITLRR 239
|
|
| DEXQc_SHPRH |
cd18070 |
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously ... |
570-819 |
4.44e-56 |
|
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously expressed protein that contains motifs characteristic of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 and is involved in DNA repair. SHPRH is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350828 [Multi-domain] Cd Length: 257 Bit Score: 195.26 E-value: 4.44e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 570 LLLHQKQALAWLLWResqkpqGGILADDMGLGKTLTMIALILTQKNQEKKeekekSTALTWLSKDDSC---------DFT 640
Cdd:cd18070 1 LLPYQRRAVNWMLVP------GGILADEMGLGKTVEVLALILLHPRPDND-----LDAADDDSDEMVCcpdclvaetPVS 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 641 SHGTLIICPASLIHHWKNEVEKRVNSNkLRVYLYHGPNRDS-----RARVLSTYDIVITTYSLVAKEIptnkQEAEIPGA 715
Cdd:cd18070 70 SKATLIVCPSAILAQWLDEINRHVPSS-LKVLTYQGVKKDGalaspAPEILAEYDIVVTTYDVLRTEL----HYAEANRS 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 716 NL------NVEGTSTPLLRIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPFD 789
Cdd:cd18070 145 NRrrrrqkRYEAPPSPLVLVEWWRVCLDEAQMVESSTSKAAEMARRLPRVNRWCVSGTPIQRGLDDLFGLLSFLGVEPFC 224
|
250 260 270
....*....|....*....|....*....|..
gi 1034562578 790 EFNLWRSQVDN--GSKKGGERLSILTKSLLLR 819
Cdd:cd18070 225 DSDWWARVLIRpqGRNKAREPLAALLKELLWR 256
|
|
| DEXHc_Snf |
cd17919 |
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ... |
570-795 |
1.09e-53 |
|
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350677 [Multi-domain] Cd Length: 182 Bit Score: 185.46 E-value: 1.09e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 570 LLLHQKQALAWLLWRESQKPqGGILADDMGLGKTLTMIALILTQKNQekkeekekstaltwlsKDDSCDFtshgtLIICP 649
Cdd:cd17919 1 LRPYQLEGLNFLLELYENGP-GGILADEMGLGKTLQAIAFLAYLLKE----------------GKERGPV-----LVVCP 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 650 ASLIHHWKNEVEKRVNSnkLRVYLYHGPNRDSRAR----VLSTYDIVITTYSLVAKEIPTnkqeaeipganlnvegtstp 725
Cdd:cd17919 59 LSVLENWEREFEKWTPD--LRVVVYHGSQRERAQIrakeKLDKFDVVLTTYETLRRDKAS-------------------- 116
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 726 LLRIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCsPFdefnLWR 795
Cdd:cd17919 117 LRKFRWDLVVVDEAHRLKNPKSQLSKALKALRAKRRLLLTGTPLQNNLEELWALLDFLDP-PF----LLR 181
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
990-1117 |
5.67e-52 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 178.44 E-value: 5.67e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 990 STKISSLLAELEAIQRNSasQKSVIVSQWTNMLKVVALHLKKHGLTYATIDGSVNPKQRMDLVEAFNHSRGPQVMLISLL 1069
Cdd:cd18793 10 SGKLEALLELLEELREPG--EKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDIRVFLLSTK 87
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1034562578 1070 AGGVGLNLTGGNHLFLLDMHWNPSLEDQACDRIYRVGQQKDVVIHRFV 1117
Cdd:cd18793 88 AGGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
|
|
| DEXQc_arch_SWI2_SNF2 |
cd18012 |
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ... |
574-822 |
1.61e-50 |
|
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350770 [Multi-domain] Cd Length: 218 Bit Score: 177.76 E-value: 1.61e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 574 QKQALAWLlWRESQKPQGGILADDMGLGKTLTMIALILTQKNQEKkeekekstaltwlskddscdftSHGTLIICPASLI 653
Cdd:cd18012 9 QKEGFNWL-SFLRHYGLGGILADDMGLGKTLQTLALLLSRKEEGR----------------------KGPSLVVAPTSLI 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 654 HHWKNEVEKRvnSNKLRVYLYHGPNRDSRA-RVLSTYDIVITTYSLVAKEIptnkqEAeipganlnvegtstpLLRIAWA 732
Cdd:cd18012 66 YNWEEEAAKF--APELKVLVIHGTKRKREKlRALEDYDLVITSYGLLRRDI-----EL---------------LKEVKFH 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 733 RIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLrcSP-----FDEFN-LWRSQVDNGSKKGG 806
Cdd:cd18012 124 YLVLDEAQNIKNPQTKTAKAVKALKADHRLALTGTPIENHLGELWSIFDFL--NPgllgsYKRFKkRFAKPIEKDGDEEA 201
|
250
....*....|....*..
gi 1034562578 807 -ERLSILTKSLLLRRTK 822
Cdd:cd18012 202 lEELKKLISPFILRRLK 218
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
563-1133 |
6.26e-41 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 164.20 E-value: 6.26e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 563 PAGLKVPLLLHQKQALAWLLwRESQKPQGGILADDMGLGKTLTMIALiltqknqekkeekekstaLTWLSkdDSCDFTS- 641
Cdd:PLN03142 163 PSCIKGKMRDYQLAGLNWLI-RLYENGINGILADEMGLGKTLQTISL------------------LGYLH--EYRGITGp 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 642 HgtLIICPASLIHHWKNEVEKRVNSnkLRVYLYHGpNRDSRAR------VLSTYDIVITTYSLVAKEiptnkqeaeipga 715
Cdd:PLN03142 222 H--MVVAPKSTLGNWMNEIRRFCPV--LRAVKFHG-NPEERAHqreellVAGKFDVCVTSFEMAIKE------------- 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 716 nlnvegtSTPLLRIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPF---DEFN 792
Cdd:PLN03142 284 -------KTALKRFSWRYIIIDEAHRIKNENSLLSKTMRLFSTNYRLLITGTPLQNNLHELWALLNFLLPEIFssaETFD 356
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 793 LWRSQvdNGSKKGGERLSILTKSL---LLRRTKDQLDSTgrplviLPQRKFQLHHLKLSEDEETVYnvffarsRSALQSY 869
Cdd:PLN03142 357 EWFQI--SGENDQQEVVQQLHKVLrpfLLRRLKSDVEKG------LPPKKETILKVGMSQMQKQYY-------KALLQKD 421
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 870 LKrhesrgnqsgrspnnpfsrvALEFGSEEPRhseaadsprsstvhILSQLLRLRQCCCHLSLLKSAL-DPMELKGEGLV 948
Cdd:PLN03142 422 LD--------------------VVNAGGERKR--------------LLNIAMQLRKCCNHPYLFQGAEpGPPYTTGEHLV 467
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 949 lsleeqlsaltlselrdsEPSStvslngtffKMELFEgmrestkisSLLAELEaiQRNSasqKSVIVSQWTNMLKVVALH 1028
Cdd:PLN03142 468 ------------------ENSG---------KMVLLD---------KLLPKLK--ERDS---RVLIFSQMTRLLDILEDY 506
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 1029 LKKHGLTYATIDGSVNPKQRMDLVEAFNHSRGPQ-VMLISLLAGGVGLNLTGGNHLFLLDMHWNPSLEDQACDRIYRVGQ 1107
Cdd:PLN03142 507 LMYRGYQYCRIDGNTGGEDRDASIDAFNKPGSEKfVFLLSTRAGGLGINLATADIVILYDSDWNPQVDLQAQDRAHRIGQ 586
|
570 580
....*....|....*....|....*.
gi 1034562578 1108 QKDVVIHRFVCEGTVEEKILQLQEKK 1133
Cdd:PLN03142 587 KKEVQVFRFCTEYTIEEKVIERAYKK 612
|
|
| DEXHc_Mot1 |
cd17999 |
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ... |
592-783 |
2.63e-33 |
|
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350757 [Multi-domain] Cd Length: 232 Bit Score: 128.62 E-value: 2.63e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 592 GILADDMGLGKTLTMIALIltqknqekkeekekstALTWLSKDDSCDFTSHGTLIICPASLIHHWKNEVEKRVNSNKLRV 671
Cdd:cd17999 22 GILCDDMGLGKTLQTLCIL----------------ASDHHKRANSFNSENLPSLVVCPPTLVGHWVAEIKKYFPNAFLKP 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 672 YLYHGPNRDSRARV--LSTYDIVITTYSLVAKEIPTnkqeaeipganlnvegtstpLLRIAWARIILDEAHNVKNPRVQT 749
Cdd:cd17999 86 LAYVGPPQERRRLReqGEKHNVIVASYDVLRNDIEV--------------------LTKIEWNYCVLDEGHIIKNSKTKL 145
|
170 180 190
....*....|....*....|....*....|....
gi 1034562578 750 SIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFL 783
Cdd:cd17999 146 SKAVKQLKANHRLILSGTPIQNNVLELWSLFDFL 179
|
|
| DEXHc_ERCC6L |
cd18001 |
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ... |
573-783 |
1.43e-32 |
|
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350759 [Multi-domain] Cd Length: 232 Bit Score: 126.72 E-value: 1.43e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 573 HQKQALAWLlWRESQKPQGGILADDMGLGKTLTMIALIltqknqekkEEKEKSTALtwlskddscdftsHGTLIICPASL 652
Cdd:cd18001 4 HQREGVAWL-WSLHDGGKGGILADDMGLGKTVQICAFL---------SGMFDSGLI-------------KSVLVVMPTSL 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 653 IHHWKNEVEKRVNSnkLRVYLYHGPNRDSRAR----VLSTYDIVITTYSLVakeipTNKQEAeipganLNVEGTSTpllr 728
Cdd:cd18001 61 IPHWVKEFAKWTPG--LRVKVFHGTSKKERERnlerIQRGGGVLLTTYGMV-----LSNTEQ------LSADDHDE---- 123
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1034562578 729 IAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFL 783
Cdd:cd18001 124 FKWDYVILDEGHKIKNSKTKSAKSLREIPAKNRIILTGTPIQNNLKELWALFDFA 178
|
|
| DEXHc_ERCC6L2 |
cd18005 |
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ... |
570-834 |
8.23e-32 |
|
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350763 [Multi-domain] Cd Length: 245 Bit Score: 124.80 E-value: 8.23e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 570 LLLHQKQALAWLLWReSQKPQGGILADDMGLGKTLTMIALILT-------------QKNQEKKEEKEKSTALTWLskdds 636
Cdd:cd18005 1 LRDYQREGVEFMYDL-YKNGRGGILGDDMGLGKTVQVIAFLAAvlgktgtrrdrenNRPRFKKKPPASSAKKPVL----- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 637 cdftshgtlIICPASLIHHWKNEVEKRvnsNKLRVYLYHGPNRD----SRARvLSTYDIVITTYSLVAKEIPTnkqeaei 712
Cdd:cd18005 75 ---------IVAPLSVLYNWKDELDTW---GHFEVGVYHGSRKDdeleGRLK-AGRLEVVVTTYDTLRRCIDS------- 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 713 pganlnvegtstpLLRIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPFDEFN 792
Cdd:cd18005 135 -------------LNSINWSAVIADEAHRIKNPKSKLTQAMKELKCKVRIGLTGTLLQNNMKELWCLLDWAVPGALGSRS 201
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 1034562578 793 LWRSQVDNGSKKGGERLSILTKSLLLRRTKDQLDSTGRPLVI 834
Cdd:cd18005 202 QFKKHFSEPIKRGQRHTATARELRLGRKRKQELAVKLSKFFL 243
|
|
| DEXHc_ERCC6 |
cd18000 |
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ... |
573-782 |
2.67e-31 |
|
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350758 [Multi-domain] Cd Length: 193 Bit Score: 121.66 E-value: 2.67e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 573 HQKQALAWLLWRESQKpQGGILADDMGLGKTLTMIALIltqknqekkeekekstaltwlskdDSCDFTSHG---TLIICP 649
Cdd:cd18000 4 YQQTGVQWLWELHCQR-VGGILGDEMGLGKTIQIIAFL------------------------AALHHSKLGlgpSLIVCP 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 650 ASLIHHWKNEVEK----------------RVNSNKLRVYLYHGPNRDsraRVLSTYDIVITTYSLVAKEiptnkqeaeip 713
Cdd:cd18000 59 ATVLKQWVKEFHRwwppfrvvvlhssgsgTGSEEKLGSIERKSQLIR---KVVGDGGILITTYEGFRKH----------- 124
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034562578 714 ganlnvegtSTPLLRIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKF 782
Cdd:cd18000 125 ---------KDLLLNHNWQYVILDEGHKIRNPDAEITLACKQLRTPHRLILSGTPIQNNLKELWSLFDF 184
|
|
| DEXHc_RAD54 |
cd18004 |
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ... |
573-820 |
3.65e-30 |
|
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350762 [Multi-domain] Cd Length: 240 Bit Score: 120.08 E-value: 3.65e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 573 HQKQALAWL----LWRESQKPQGGILADDMGLGKTLTMIALILTQKNQekkeekekstaltwlSKDDSCdfTSHGTLIIC 648
Cdd:cd18004 4 HQREGVQFLydclTGRRGYGGGGAILADEMGLGKTLQAIALVWTLLKQ---------------GPYGKP--TAKKALIVC 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 649 PASLIHHWKNEVEKRVNSNKLRVYLYHGPNRDSRARVL-----STYDIVITTYSLVAKEiptnkqeaeipgANLNVEGTS 723
Cdd:cd18004 67 PSSLVGNWKAEFDKWLGLRRIKVVTADGNAKDVKASLDffssaSTYPVLIISYETLRRH------------AEKLSKKIS 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 724 TPLLriawariILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPFDEFNLWRSQVDNGSK 803
Cdd:cd18004 135 IDLL-------ICDEGHRLKNSESKTTKALNSLPCRRRLLLTGTPIQNDLDEFFALVDFVNPGILGSLASFRKVFEEPIL 207
|
250 260 270
....*....|....*....|....*....|...
gi 1034562578 804 KGGER----------------LSILTKSLLLRR 820
Cdd:cd18004 208 RSRDPdaseedkelgaersqeLSELTSRFILRR 240
|
|
| DEXHc_SMARCA1_SMARCA5 |
cd17997 |
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ... |
573-822 |
1.69e-28 |
|
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350755 [Multi-domain] Cd Length: 222 Bit Score: 114.73 E-value: 1.69e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 573 HQKQALAWLLwreSQKPQG--GILADDMGLGKTLTMIALI--LTQ-KNQEKkeekekstaltwlskddscdftSHgtLII 647
Cdd:cd17997 7 YQIRGLNWLI---SLFENGinGILADEMGLGKTLQTISLLgyLKHyKNING----------------------PH--LII 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 648 CPASLIHHWKNEVEKRVNSnkLRVYLYHGpNRDSRARVLST------YDIVITTYSLVAKEiptnkqeaeipganlnveg 721
Cdd:cd17997 60 VPKSTLDNWMREFKRWCPS--LRVVVLIG-DKEERADIIRDvllpgkFDVCITSYEMVIKE------------------- 117
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 722 tSTPLLRIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPF---DEFNLW--RS 796
Cdd:cd17997 118 -KTVLKKFNWRYIIIDEAHRIKNEKSKLSQIVRLFNSRNRLLLTGTPLQNNLHELWALLNFLLPDVFtssEDFDEWfnVN 196
|
250 260
....*....|....*....|....*.
gi 1034562578 797 QVDNGSKKGGERLSILTKSLLLRRTK 822
Cdd:cd17997 197 NCDDDNQEVVQRLHKVLRPFLLRRIK 222
|
|
| DEXQc_SRCAP |
cd18003 |
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ... |
573-820 |
1.22e-27 |
|
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350761 [Multi-domain] Cd Length: 223 Bit Score: 112.06 E-value: 1.22e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 573 HQKQALAWLLwRESQKPQGGILADDMGLGKTLTMIALiltqknqekkeekekstaLTWLSkddsCDFTSHGT-LIICPAS 651
Cdd:cd18003 4 YQHIGLDWLA-TLYEKNLNGILADEMGLGKTIQTIAL------------------LAHLA----CEKGNWGPhLIVVPTS 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 652 LIHHWKNEVEKRVNSNKLRVYlYHGPNRDSRARV----LSTYDIVITTYSLVAKEiptnkqeaeipganlnvegtSTPLL 727
Cdd:cd18003 61 VMLNWEMEFKRWCPGFKILTY-YGSAKERKLKRQgwmkPNSFHVCITSYQLVVQD--------------------HQVFK 119
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 728 RIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPF---DEFNLWRSQVDNGSKK 804
Cdd:cd18003 120 RKKWKYLILDEAHNIKNFKSQRWQTLLNFNTQRRLLLTGTPLQNSLMELWSLMHFLMPHIFqshQEFKEWFSNPLTAMSE 199
|
250 260
....*....|....*....|....
gi 1034562578 805 GGE--------RLSILTKSLLLRR 820
Cdd:cd18003 200 GSQeeneelvrRLHKVLRPFLLRR 223
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
569-798 |
3.55e-23 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 98.72 E-value: 3.55e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 569 PLLLHQKQALAWLLWREsqkpQGGILADDMGLGKTLTMIALILTQKNQEKKEEkekstaltwlskddscdftshgTLIIC 648
Cdd:smart00487 8 PLRPYQKEAIEALLSGL----RDVILAAPTGSGKTLAALLPALEALKRGKGGR----------------------VLVLV 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 649 P-ASLIHHWKNEVEKRVNSNKLR-VYLYHGPNRDSRARVLST--YDIVITTYSLVAKEIPTNKqeaeipganlnvegtst 724
Cdd:smart00487 62 PtRELAEQWAEELKKLGPSLGLKvVGLYGGDSKREQLRKLESgkTDILVTTPGRLLDLLENDK----------------- 124
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034562578 725 pLLRIAWARIILDEAHNVKNP--RVQTSIAVCKLQACA-RWAVTGTPIQNNLLDMYSLLK-FLRCSPFDEFNLWRSQV 798
Cdd:smart00487 125 -LSLSNVDLVILDEAHRLLDGgfGDQLEKLLKLLPKNVqLLLLSATPPEEIENLLELFLNdPVFIDVGFTPLEPIEQF 201
|
|
| DEXHc_HELLS_SMARCA6 |
cd18009 |
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ... |
570-822 |
5.12e-23 |
|
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350767 [Multi-domain] Cd Length: 236 Bit Score: 99.00 E-value: 5.12e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 570 LLLHQKQALAWL--LWresQKPQGGILADDMGLGKTLTMIALIltqknqekkeekekstALTWLSKDDScdftshGTLII 647
Cdd:cd18009 4 MRPYQLEGMEWLrmLW---ENGINGILADEMGLGKTIQTIALL----------------AHLRERGVWG------PFLVI 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 648 CPASLIHHWKNEVEKRVNSnkLRVYLYHGPN---------RDSRARVLSTYDIVITTYslvakEIPTNKQEAeipganln 718
Cdd:cd18009 59 APLSTLPNWVNEFARFTPS--VPVLLYHGTKeererlrkkIMKREGTLQDFPVVVTSY-----EIAMRDRKA-------- 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 719 vegtstpLLRIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPFD---EFNLW- 794
Cdd:cd18009 124 -------LQHYAWKYLIVDEGHRLKNLNCRLIQELKTFNSDNRLLLTGTPLQNNLSELWSLLNFLLPDVFDdlsSFESWf 196
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 1034562578 795 -----RSQVDNGSKKGGERLSILTKSL-------LLRRTK 822
Cdd:cd18009 197 dfsslSDNAADISNLSEEREQNIVHMLhailkpfLLRRLK 236
|
|
| DEXHc_ATRX-like |
cd18007 |
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ... |
570-784 |
5.86e-23 |
|
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350765 [Multi-domain] Cd Length: 239 Bit Score: 98.90 E-value: 5.86e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 570 LLLHQKQALAWLlWR-------ESQKPQGGILADDMGLGKTLTMIALILTqknqekkeekekstaltWLSKDDscdFTSH 642
Cdd:cd18007 1 LKPHQVEGVRFL-WSnlvgtdvGSDEGGGCILAHTMGLGKTLQVITFLHT-----------------YLAAAP---RRSR 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 643 gTLIICPASLIHHWKNEVEK----RVNSNKLRVYLYHGPNRDSRARVLSTY----DIVITTYS----LVAKEIPTNKQEA 710
Cdd:cd18007 60 -PLVLCPASTLYNWEDEFKKwlppDLRPLLVLVSLSASKRADARLRKINKWhkegGVLLIGYElfrnLASNATTDPRLKQ 138
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034562578 711 EIPGANLnVEGTSTpllriawarIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLR 784
Cdd:cd18007 139 EFIAALL-DPGPDL---------LVLDEGHRLKNEKSQLSKALSKVKTKRRILLTGTPLQNNLKEYWTMVDFAR 202
|
|
| DEXHc_CHD6_7_8_9 |
cd17995 |
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ... |
574-820 |
6.08e-23 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350753 [Multi-domain] Cd Length: 223 Bit Score: 98.47 E-value: 6.08e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 574 QKQALAWLL--WRESQkpqGGILADDMGLGKTLTMIALIltqknqekkeekekstaltwlskdDSCdFTSHGT----LII 647
Cdd:cd17995 5 QLEGVNWLLfnWYNRR---NCILADEMGLGKTIQSIAFL------------------------EHL-YQVEGIrgpfLVI 56
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 648 CPASLIHHWKNEVEKRVNsnkLRVYLYHGpNRDSRARVLS-----------------TYDIVITTYSLVAKEIPTnkqea 710
Cdd:cd17995 57 APLSTIPNWQREFETWTD---MNVVVYHG-SGESRQIIQQyemyfkdaqgrkkkgvyKFDVLITTYEMVIADAEE----- 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 711 eipganlnvegtstpLLRIAWARIILDEAHNVKNP--RVQTSIAVCKLQACArwAVTGTPIQNNLLDMYSLLKFLRCSPF 788
Cdd:cd17995 128 ---------------LRKIPWRVVVVDEAHRLKNRnsKLLQGLKKLTLEHKL--LLTGTPLQNNTEELWSLLNFLEPEKF 190
|
250 260 270
....*....|....*....|....*....|....*
gi 1034562578 789 DefNLWRSQVDNGSKKGGE---RLSILTKSLLLRR 820
Cdd:cd17995 191 P--SSEEFLEEFGDLKTAEqveKLQALLKPYMLRR 223
|
|
| DEXHc_CHD1L |
cd18006 |
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ... |
573-820 |
1.01e-21 |
|
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350764 [Multi-domain] Cd Length: 216 Bit Score: 94.81 E-value: 1.01e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 573 HQKQALAWLL-WRESQkpQGGILADDMGLGKTLTMIALILTQKNQEKKEEKEkstaltwlskddscdftshgtLIICPAS 651
Cdd:cd18006 4 YQLEGVNWLLqCRAEQ--HGCILGDEMGLGKTCQTISLLWYLAGRLKLLGPF---------------------LVLCPLS 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 652 LIHHWKNEVEKRVNSnkLRVYLYHGpNRDSRA------RVLSTYDIVITTYSLVAKEiptnkqeaeipganlnvegtSTP 725
Cdd:cd18006 61 VLDNWKEELNRFAPD--LSVITYMG-DKEKRLdlqqdiKSTNRFHVLLTTYEICLKD--------------------ASF 117
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 726 LLRIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPF-----DEFNLWRSQVDN 800
Cdd:cd18006 118 LKSFPWASLVVDEAHRLKNQNSLLHKTLSEFSVDFRLLLTGTPIQNSLQELYALLSFIEPNVFpkdklDDFIKAYSETDD 197
|
250 260
....*....|....*....|
gi 1034562578 801 GSKKGGERLSILTKsLLLRR 820
Cdd:cd18006 198 ESETVEELHLLLQP-FLLRR 216
|
|
| DEXHc_SMARCA1 |
cd18065 |
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ... |
569-822 |
1.63e-21 |
|
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350823 [Multi-domain] Cd Length: 233 Bit Score: 94.70 E-value: 1.63e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 569 PLLLHQKQALAWLLwRESQKPQGGILADDMGLGKTLTMIALILTQKNQEKKEEKEkstaltwlskddscdftshgtLIIC 648
Cdd:cd18065 15 TLRDYQVRGLNWMI-SLYENGVNGILADEMGLGKTLQTIALLGYLKHYRNIPGPH---------------------MVLV 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 649 PASLIHHWKNEVEKRVNSnkLRVYLYHGpNRDSRARVL------STYDIVITTYSLVAKEIPTNKqeaeipganlnvegt 722
Cdd:cd18065 73 PKSTLHNWMNEFKRWVPS--LRAVCLIG-DKDARAAFIrdvmmpGEWDVCVTSYEMVIKEKSVFK--------------- 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 723 stpllRIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPF---DEFNLWRSQVD 799
Cdd:cd18065 135 -----KFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFnsaDDFDSWFDTKN 209
|
250 260
....*....|....*....|....
gi 1034562578 800 N-GSKKGGERLSILTKSLLLRRTK 822
Cdd:cd18065 210 ClGDQKLVERLHAVLKPFLLRRIK 233
|
|
| DEXHc_RAD54B |
cd18066 |
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ... |
573-787 |
1.83e-21 |
|
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350824 [Multi-domain] Cd Length: 235 Bit Score: 94.53 E-value: 1.83e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 573 HQKQALAWLLWRESQKP----QGGILADDMGLGKTLTMIALILTQKNQEKkeekekstaltwlskdDSCDFTSHGTLIIC 648
Cdd:cd18066 4 HQREGIEFLYECVMGMRvnerFGAILADEMGLGKTLQCISLIWTLLRQGP----------------YGGKPVIKRALIVT 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 649 PASLIHHWKNEVEKRVNSNKLRVYLYHGPNRDSRARVLSTYDIVITTYSLVAKEIptnkqeAEIPGANLNVegtstpllr 728
Cdd:cd18066 68 PGSLVKNWKKEFQKWLGSERIKVFTVDQDHKVEEFIASPLYSVLIISYEMLLRSL------DQISKLNFDL--------- 132
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 1034562578 729 iawarIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFlrCSP 787
Cdd:cd18066 133 -----VICDEGHRLKNTSIKTTTALTSLSCERRIILTGTPIQNDLQEFFALIDF--VNP 184
|
|
| DEXHc_SMARCA2_SMARCA4 |
cd17996 |
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ... |
573-792 |
5.99e-21 |
|
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350754 [Multi-domain] Cd Length: 233 Bit Score: 93.20 E-value: 5.99e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 573 HQKQALAWLLWRESQKpQGGILADDMGLGKTLTMIALIltqknqekkeekeksTALTWLSKDdscdftsHGT-LIICPAS 651
Cdd:cd17996 7 YQLKGLQWMVSLYNNN-LNGILADEMGLGKTIQTISLI---------------TYLMEKKKN-------NGPyLVIVPLS 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 652 LIHHWKNEVEKRVNSnkLRVYLYHGPnRDSRARVLST-----YDIVITTYSLVAKEIPTnkqeaeipganlnvegtstpL 726
Cdd:cd17996 64 TLSNWVSEFEKWAPS--VSKIVYKGT-PDVRKKLQSQiragkFNVLLTTYEYIIKDKPL--------------------L 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 727 LRIAWARIILDEAHNVKNprvqtsiAVCKL--------QACARWAVTGTPIQNNLLDMYSLLKFL------RCSPFDE-F 791
Cdd:cd17996 121 SKIKWKYMIIDEGHRMKN-------AQSKLtqtlntyyHARYRLLLTGTPLQNNLPELWALLNFLlpkifkSCKTFEQwF 193
|
.
gi 1034562578 792 N 792
Cdd:cd17996 194 N 194
|
|
| DEXHc_SMARCAD1 |
cd17998 |
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ... |
573-788 |
1.74e-20 |
|
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350756 [Multi-domain] Cd Length: 187 Bit Score: 90.52 E-value: 1.74e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 573 HQKQALAWLLWRESQKpQGGILADDMGLGKTLTMIALI--LTQKNqekkeekekstaltwlskddscdftSHGT-LIICP 649
Cdd:cd17998 4 YQLIGLNWLNLLYQKK-LSGILADEMGLGKTIQVIAFLayLKEIG-------------------------IPGPhLVVVP 57
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 650 ASLIHHWKNEVEKRVNSnkLRVYLYHGpNRDSRARV-------LSTYDIVITTYSLVAkeipTNKQEAE-IPGANLNVeg 721
Cdd:cd17998 58 SSTLDNWLREFKRWCPS--LKVEPYYG-SQEERKHLrydilkgLEDFDVIVTTYNLAT----SNPDDRSfFKRLKLNY-- 128
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034562578 722 tstpllriawarIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPF 788
Cdd:cd17998 129 ------------VVYDEGHMLKNMTSERYRHLMTINANFRLLLTGTPLQNNLLELMSLLNFIMPKPF 183
|
|
| DEXQc_INO80 |
cd18002 |
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ... |
573-820 |
2.63e-19 |
|
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350760 [Multi-domain] Cd Length: 229 Bit Score: 88.33 E-value: 2.63e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 573 HQKQALAWLLwreSQKPQG--GILADDMGLGKTLTMIALiltqknqekkeekekstaLTWLSKDdscdftsHGT----LI 646
Cdd:cd18002 4 YQLKGLNWLA---NLYEQGinGILADEMGLGKTVQSIAV------------------LAHLAEE-------HNIwgpfLV 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 647 ICPASLIHHWKNEVEKRVNsnKLRVYLYHGPNRD--------SRARVL---STYDIVITTYSLVAKEIPTnkqeaeipga 715
Cdd:cd18002 56 IAPASTLHNWQQEISRFVP--QFKVLPYWGNPKDrkvlrkfwDRKNLYtrdAPFHVVITSYQLVVQDEKY---------- 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 716 nlnvegtstpLLRIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPFD---EFN 792
Cdd:cd18002 124 ----------FQRVKWQYMVLDEAQAIKSSSSSRWKTLLSFHCRNRLLLTGTPIQNSMAELWALLHFIMPTLFDshdEFN 193
|
250 260 270
....*....|....*....|....*....|....*.
gi 1034562578 793 LWRSQ-VDNGSKKGG-------ERLSILTKSLLLRR 820
Cdd:cd18002 194 EWFSKdIESHAENKTglnehqlKRLHMILKPFMLRR 229
|
|
| DEXHc_SMARCA5 |
cd18064 |
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ... |
573-831 |
4.31e-19 |
|
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350822 [Multi-domain] Cd Length: 244 Bit Score: 88.18 E-value: 4.31e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 573 HQKQALAWLLwRESQKPQGGILADDMGLGKTLTMIALILTQKNQEKKEEKEkstaltwlskddscdftshgtLIICPASL 652
Cdd:cd18064 19 YQVRGLNWLI-SLYENGINGILADEMGLGKTLQTISLLGYMKHYRNIPGPH---------------------MVLVPKST 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 653 IHHWKNEVEKRVNSnkLRVYLYHGpNRDSRARVL------STYDIVITTYSLVAKEIPTNKqeaeipganlnvegtstpl 726
Cdd:cd18064 77 LHNWMAEFKRWVPT--LRAVCLIG-DKDQRAAFVrdvllpGEWDVCVTSYEMLIKEKSVFK------------------- 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 727 lRIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPF---DEFNLWRSQVDN-GS 802
Cdd:cd18064 135 -KFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFnsaEDFDSWFDTNNClGD 213
|
250 260
....*....|....*....|....*....
gi 1034562578 803 KKGGERLSILTKSLLLRRTKDQLDSTGRP 831
Cdd:cd18064 214 QKLVERLHMVLRPFLLRRIKADVEKSLPP 242
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
992-1106 |
5.65e-19 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 83.41 E-value: 5.65e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 992 KISSLLAELEAIQRNsasqKSVIVSQWTNMLKVVALhLKKHGLTYATIDGSVNPKQRMDLVEAFNhsRGPQVMLISLLAG 1071
Cdd:pfam00271 2 KLEALLELLKKERGG----KVLIFSQTKKTLEAELL-LEKEGIKVARLHGDLSQEEREEILEDFR--KGKIDVLVATDVA 74
|
90 100 110
....*....|....*....|....*....|....*
gi 1034562578 1072 GVGLNLTGGNHLFLLDMHWNPSLEDQACDRIYRVG 1106
Cdd:pfam00271 75 ERGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEXHc_CHD1_2 |
cd17993 |
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ... |
574-820 |
1.13e-18 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350751 [Multi-domain] Cd Length: 218 Bit Score: 85.87 E-value: 1.13e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 574 QKQALAWL--LWresQKPQGGILADDMGLGKTLTMIALiltqknqekkeekekstaLTWLSKDdscdFTSHGT-LIICPA 650
Cdd:cd17993 6 QLTGLNWLahSW---CKGNNGILADEMGLGKTVQTISF------------------LSYLFHS----QQQYGPfLVVVPL 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 651 SLIHHWKNEVEKRVNSNKLRVYLyhgPNRDSRArVLSTYD------------IVITTYSLVAKEiptnKQEaeipganln 718
Cdd:cd17993 61 STMPAWQREFAKWAPDMNVIVYL---GDIKSRD-TIREYEfyfsqtkklkfnVLLTTYEIILKD----KAF--------- 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 719 vegtstpLLRIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPFDEFNLWRSQV 798
Cdd:cd17993 124 -------LGSIKWQYLAVDEAHRLKNDESLLYEALKEFKTNNRLLITGTPLQNSLKELWALLHFLMPGKFDIWEEFEEEH 196
|
250 260
....*....|....*....|..
gi 1034562578 799 DNGSKKGGERLSILTKSLLLRR 820
Cdd:cd17993 197 DEEQEKGIADLHKELEPFILRR 218
|
|
| DEXHc_HARP_SMARCAL1 |
cd18010 |
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ... |
570-820 |
1.01e-17 |
|
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350768 [Multi-domain] Cd Length: 213 Bit Score: 83.02 E-value: 1.01e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 570 LLLHQKQALAWLLWREsqkpqGGIL-ADDMGLGKTLTMIALILTQKNQekkeekekstaltW-LskddscdftshgtLII 647
Cdd:cd18010 1 LLPFQREGVCFALRRG-----GRVLiADEMGLGKTVQAIAIAAYYREE-------------WpL-------------LIV 49
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 648 CPASLIHHWKNEVEKRVNS-NKLRVYLYHGPNRDSRArvlSTYDIVITTYSLVAKEiptnkqeaeipganlnvegtSTPL 726
Cdd:cd18010 50 CPSSLRLTWADEIERWLPSlPPDDIQVIVKSKDGLRD---GDAKVVIVSYDLLRRL--------------------EKQL 106
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 727 LRIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAV--TGTPIQNNLLDMYSLLKFLR---CSPFDEFNLWRSQVDNG 801
Cdd:cd18010 107 LARKFKVVICDESHYLKNSKAKRTKAALPLLKRAKRVIllSGTPALSRPIELFTQLDALDpklFGRFHDFGRRYCAAKQG 186
|
250 260
....*....|....*....|....*..
gi 1034562578 802 SK----KGGERL----SILTKSLLLRR 820
Cdd:cd18010 187 GFgwdySGSSNLeelhLLLLATIMIRR 213
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
1025-1106 |
2.37e-16 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 74.94 E-value: 2.37e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 1025 VALHLKKHGLTYATIDGSVNPKQRMDLVEAFNhsRGPQVMLISLLAGGVGLNLTGGNHLFLLDMHWNPSLEDQACDRIYR 1104
Cdd:smart00490 3 LAELLKELGIKVARLHGGLSQEEREEILDKFN--NGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGR 80
|
..
gi 1034562578 1105 VG 1106
Cdd:smart00490 81 AG 82
|
|
| DEXDc_RapA |
cd18011 |
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ... |
570-783 |
5.49e-16 |
|
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350769 [Multi-domain] Cd Length: 207 Bit Score: 78.10 E-value: 5.49e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 570 LLLHQKQALAWLLwreSQKPQGGILADDMGLGKTLTMIALILtqknqekkeekekstALTWLSKDDSCdftshgtLIICP 649
Cdd:cd18011 1 PLPHQIDAVLRAL---RKPPVRLLLADEVGLGKTIEAGLIIK---------------ELLLRGDAKRV-------LILCP 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 650 ASLIHHWKNEVEKRVNSNKLRVY-LYHGPNRDSRARVLSTYDIVITTYSLVakeiptnKQEAEIPGAnlnvegtstpLLR 728
Cdd:cd18011 56 ASLVEQWQDELQDKFGLPFLILDrETAAQLRRLIGNPFEEFPIVIVSLDLL-------KRSEERRGL----------LLS 118
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034562578 729 IAWARIILDEAHNVKN---PRVQTSIAVCKLQACARWAV---TGTPIQNNLLDMYSLLKFL 783
Cdd:cd18011 119 EEWDLVVVDEAHKLRNsggGKETKRYKLGRLLAKRARHVlllTATPHNGKEEDFRALLSLL 179
|
|
| DEXHc_CHD8 |
cd18060 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ... |
573-820 |
8.63e-16 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350818 [Multi-domain] Cd Length: 222 Bit Score: 77.79 E-value: 8.63e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 573 HQKQALAWLLWRESQKpQGGILADDMGLGKTLTMIALILTQKNQEKKEEKekstaltwlskddscdftshgtLIICPASL 652
Cdd:cd18060 4 YQLEGVNWLLFNWYNR-QNCILADEMGLGKTIQSIAFLQEVYNVGIHGPF----------------------LVIAPLST 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 653 IHHWKNEVEKRVNSNKLrvyLYHGP-------------NRDSRARVLS---TYDIVITTYSLVAKEIPTnkqeaeipgan 716
Cdd:cd18060 61 ITNWEREFNTWTEMNTI---VYHGSlasrqmiqqyemyCKDSRGRLIPgayKFDALITTFEMILSDCPE----------- 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 717 lnvegtstpLLRIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPF-DEFNLWR 795
Cdd:cd18060 127 ---------LREIEWRCVIIDEAHRLKNRNCKLLDSLKHMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSQFpSESEFLK 197
|
250 260
....*....|....*....|....*
gi 1034562578 796 SQVDNGSKKGGERLSILTKSLLLRR 820
Cdd:cd18060 198 DFGDLKTEEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_CHD2 |
cd18054 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ... |
573-820 |
6.93e-15 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350812 [Multi-domain] Cd Length: 237 Bit Score: 75.43 E-value: 6.93e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 573 HQKQALAWLL--WRESQKPqggILADDMGLGKTLTMIALiltqknqekkeekekstaLTWLskddscdFTSHGT----LI 646
Cdd:cd18054 24 YQLEGLNWLAhsWCKNNSV---ILADEMGLGKTIQTISF------------------LSYL-------FHQHQLygpfLL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 647 ICPASLIHHWKNEVEKRVNSNKLRVYLYHGPNRD---------SRARVLStYDIVITTYSLVAKEiptnkqeaeipganl 717
Cdd:cd18054 76 VVPLSTLTSWQREFEIWAPEINVVVYIGDLMSRNtireyewihSQTKRLK-FNALITTYEILLKD--------------- 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 718 nvegtSTPLLRIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPFDEFNLWRSQ 797
Cdd:cd18054 140 -----KTVLGSINWAFLGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFEFWEDFEED 214
|
250 260
....*....|....*....|...
gi 1034562578 798 VDNGSKKGGERLSILTKSLLLRR 820
Cdd:cd18054 215 HGKGRENGYQSLHKVLEPFLLRR 237
|
|
| DEXHc_CHD6 |
cd18058 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ... |
573-820 |
3.11e-14 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350816 [Multi-domain] Cd Length: 222 Bit Score: 73.15 E-value: 3.11e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 573 HQKQALAWLLWRESQKpQGGILADDMGLGKTLTMIaliltqknqekkeekekstalTWLSkdDSCDFTSHGT-LIICPAS 651
Cdd:cd18058 4 YQLEGMNWLLFNWYNR-KNCILADEMGLGKTIQSI---------------------TFLS--EIFLMGIRGPfLIIAPLS 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 652 LIHHWKNEVEKRVNSNklrVYLYHGPN-------------RDSRARVLS---TYDIVITTYSLVAKEIPTnkqeaeipga 715
Cdd:cd18058 60 TITNWEREFRTWTEMN---AIVYHGSQisrqmiqqyemyyRDEQGNPLSgifKFQVVITTFEMILADCPE---------- 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 716 nlnvegtstpLLRIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPF-DEFNLW 794
Cdd:cd18058 127 ----------LKKINWSCVIIDEAHRLKNRNCKLLEGLKLMALEHKVLLTGTPLQNSVEELFSLLNFLEPSQFpSETTFL 196
|
250 260
....*....|....*....|....*.
gi 1034562578 795 RSQVDNGSKKGGERLSILTKSLLLRR 820
Cdd:cd18058 197 EEFGDLKTEEQVKKLQSILKPMMLRR 222
|
|
| DEXHc_RAD54A |
cd18067 |
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ... |
573-782 |
7.17e-14 |
|
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350825 [Multi-domain] Cd Length: 243 Bit Score: 72.50 E-value: 7.17e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 573 HQKQALAWLlWR--ESQKPQGG---ILADDMGLGKTLTMIALIltqknqekkeekekstaLTWLSKDDSCDFTSHGTLII 647
Cdd:cd18067 4 HQREGVKFL-YRcvTGRRIRGShgcIMADEMGLGKTLQCITLM-----------------WTLLRQSPQCKPEIDKAIVV 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 648 CPASLIHHWKNEVEKRVNSNkLRVYLYHGPNRDSRARVLStydivittyslvakeiptnkQEAEIPGANLnvegtSTPLL 727
Cdd:cd18067 66 SPSSLVKNWANELGKWLGGR-LQPLAIDGGSKKEIDRKLV--------------------QWASQQGRRV-----STPVL 119
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 728 RIAW---------------ARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKF 782
Cdd:cd18067 120 IISYetfrlhvevlqkgevGLVICDEGHRLKNSDNQTYQALDSLNTQRRVLLSGTPIQNDLSEYFSLVNF 189
|
|
| DEXQc_bact_SNF2 |
cd18013 |
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ... |
573-783 |
3.27e-12 |
|
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350771 [Multi-domain] Cd Length: 218 Bit Score: 67.37 E-value: 3.27e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 573 HQKQALAWLLwresQKPQGGILADdMGLGKTLTMIaliltqknqekkeekeksTALTWLSKDdscDFTSHgTLIICPASL 652
Cdd:cd18013 4 YQKVAINFII----EHPYCGLFLD-MGLGKTVTTL------------------TALSDLQLD---DFTRR-VLVIAPLRV 56
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 653 IHH-WKNEVEKRVNSNKLRVYLYHGPNRDSRARVLSTYDIVITTYSLVAKEIptNKQEAEIPganlnvegtstpllriaW 731
Cdd:cd18013 57 ARStWPDEVEKWNHLRNLTVSVAVGTERQRSKAANTPADLYVINRENLKWLV--NKSGDPWP-----------------F 117
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1034562578 732 ARIILDEAHNVKNPRVQTSIAVCKLQACARWAV--TGTPIQNNLLDMYSLLKFL 783
Cdd:cd18013 118 DMVVIDELSSFKSPRSKRFKALRKVRPVIKRLIglTGTPSPNGLMDLWAQIALL 171
|
|
| DEXHc_CHD7 |
cd18059 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ... |
573-820 |
1.04e-11 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350817 [Multi-domain] Cd Length: 222 Bit Score: 65.82 E-value: 1.04e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 573 HQKQALAWLL--WRESQKpqgGILADDMGLGKTLTMIALILTqknqekkeekekstalTWLSKddscdftSHGT-LIICP 649
Cdd:cd18059 4 YQLEGVNWLLfnWYNTRN---CILADEMGLGKTIQSITFLYE----------------IYLKG-------IHGPfLVIAP 57
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 650 ASLIHHWKNEVEkrvNSNKLRVYLYHGPN-------------RDSRARVLS---TYDIVITTYSLVAKEIPTnkqeaeip 713
Cdd:cd18059 58 LSTIPNWEREFR---TWTELNVVVYHGSQasrrtiqlyemyfKDPQGRVIKgsyKFHAIITTFEMILTDCPE-------- 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 714 ganlnvegtstpLLRIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPF-DEFN 792
Cdd:cd18059 127 ------------LRNIPWRCVVIDEAHRLKNRNCKLLEGLKMMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSRFpSETT 194
|
250 260
....*....|....*....|....*...
gi 1034562578 793 LWRSQVDNGSKKGGERLSILTKSLLLRR 820
Cdd:cd18059 195 FMQEFGDLKTEEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_SMARCA2 |
cd18063 |
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ... |
573-822 |
1.16e-11 |
|
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350821 [Multi-domain] Cd Length: 251 Bit Score: 66.24 E-value: 1.16e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 573 HQKQALAWLLWRESQKpQGGILADDMGLGKTLTMIALIltqknqekkeekekstalTWLSKDDSCDFTshgTLIICPASL 652
Cdd:cd18063 27 YQLQGLEWMVSLYNNN-LNGILADEMGLGKTIQTIALI------------------TYLMEHKRLNGP---YLIIVPLST 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 653 IHHWKNEVEKRVNSNKLRVYLYHGPNRDSRARVLST--YDIVITTYSLVAKEiptnkqeaeipganlnvegtSTPLLRIA 730
Cdd:cd18063 85 LSNWTYEFDKWAPSVVKISYKGTPAMRRSLVPQLRSgkFNVLLTTYEYIIKD--------------------KHILAKIR 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 731 WARIILDEAHNVKNPRVQ-TSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFL------RCSPFDE-----FNLWRSQV 798
Cdd:cd18063 145 WKYMIVDEGHRMKNHHCKlTQVLNTHYVAPRRILLTGTPLQNKLPELWALLNFLlptifkSCSTFEQwfnapFAMTGERV 224
|
250 260
....*....|....*....|....*..
gi 1034562578 799 DNGSKKG---GERLSILTKSLLLRRTK 822
Cdd:cd18063 225 DLNEEETiliIRRLHKVLRPFLLRRLK 251
|
|
| DEXHc_CHD9 |
cd18061 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ... |
573-820 |
2.25e-11 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350819 [Multi-domain] Cd Length: 222 Bit Score: 65.03 E-value: 2.25e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 573 HQKQALAWLLWRESQKpQGGILADDMGLGKTLTMIALIltqknqekkeekeKSTALTWLSKDdscdftshgTLIICPASL 652
Cdd:cd18061 4 YQLEGLNWLLFNWYNR-RNCILADEMGLGKTIQSITFL-------------YEILLTGIRGP---------FLIIAPLST 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 653 IHHWKNEVEKRVNSNklrVYLYHGP-------------NRDSRARVLS---TYDIVITTYSLVAkeiptnkqeaeipgan 716
Cdd:cd18061 61 IANWEREFRTWTDLN---VVVYHGSlisrqmiqqyemyFRDSQGRIIRgayRFQAIITTFEMIL---------------- 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 717 lnveGTSTPLLRIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPFDEFNLWRS 796
Cdd:cd18061 122 ----GGCPELNAIDWRCVIIDEAHRLKNKNCKLLEGLKLMNLEHKVLLTGTPLQNTVEELFSLLHFLEPLRFPSESTFMQ 197
|
250 260
....*....|....*....|....*
gi 1034562578 797 QV-DNGSKKGGERLSILTKSLLLRR 820
Cdd:cd18061 198 EFgDLKTEEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_CHD3_4_5 |
cd17994 |
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ... |
573-820 |
3.04e-11 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350752 [Multi-domain] Cd Length: 196 Bit Score: 64.00 E-value: 3.04e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 573 HQKQALAWLLWRESQKPQGgILADDMGLGKTLTMIALILTqknqekkeekekstaltwLSKDDSCD--FtshgtLIICPA 650
Cdd:cd17994 4 YQLEGLNWLRFSWAQGTDT-ILADEMGLGKTIQTIVFLYS------------------LYKEGHSKgpF-----LVSAPL 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 651 SLIHHWKNEVEkrVNSNKLRVYLYHGPNrdsrarvlstydIVITTYSLVAKEIPTnkqeaeipganlnvegtstpLLRIA 730
Cdd:cd17994 60 STIINWEREFE--MWAPDFYVVTYVGDH------------VLLTSYELISIDQAI--------------------LGSID 105
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 731 WARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPFDEFNLWRSQVDNGSKKGG-ERL 809
Cdd:cd17994 106 WAVLVVDEAHRLKNNQSKFFRILNSYKIGYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLQGFLEEFADISKEDQiKKL 185
|
250
....*....|.
gi 1034562578 810 SILTKSLLLRR 820
Cdd:cd17994 186 HDLLGPHMLRR 196
|
|
| DEXHc_SMARCA4 |
cd18062 |
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ... |
573-822 |
4.74e-11 |
|
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350820 [Multi-domain] Cd Length: 251 Bit Score: 64.30 E-value: 4.74e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 573 HQKQALAWLLWRESQKpQGGILADDMGLGKTLTMIALIltqknqekkeekekstalTWLSKDDSCDFTshgTLIICPASL 652
Cdd:cd18062 27 YQIKGLEWLVSLYNNN-LNGILADEMGLGKTIQTIALI------------------TYLMEHKRINGP---FLIIVPLST 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 653 IHHWKNEVEKRVNSnkLRVYLYHGPNRDSRARV----LSTYDIVITTYSLVAKEiptnkqeaeipganlnvegtSTPLLR 728
Cdd:cd18062 85 LSNWVYEFDKWAPS--VVKVSYKGSPAARRAFVpqlrSGKFNVLLTTYEYIIKD--------------------KQILAK 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 729 IAWARIILDEAHNVKNPRVQ-TSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFL------RCSPFDE-----FNLWRS 796
Cdd:cd18062 143 IRWKYMIVDEGHRMKNHHCKlTQVLNTHYVAPRRLLLTGTPLQNKLPELWALLNFLlptifkSCSTFEQwfnapFAMTGE 222
|
250 260
....*....|....*....|....*....
gi 1034562578 797 QVDNGSKKG---GERLSILTKSLLLRRTK 822
Cdd:cd18062 223 KVDLNEEETiliIRRLHKVLRPFLLRRLK 251
|
|
| DEXHc_ATRX |
cd18068 |
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ... |
584-784 |
1.12e-10 |
|
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350826 [Multi-domain] Cd Length: 246 Bit Score: 63.37 E-value: 1.12e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 584 RESQKPQG--GILADDMGLGKTLTMIALILTqknqekkeekekstaLTWLSKDDSCDftshGTLIICPASLIHHWKNEVE 661
Cdd:cd18068 21 KKTKKSPGsgCILAHCMGLGKTLQVVTFLHT---------------VLLCEKLENFS----RVLVVCPLNTVLNWLNEFE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 662 KRV----NSNKLRVY---LYHGPNRDSRA--RVLSTYDIVITTYSL-----VAKEIPTNKQEAEI-------PGANLnve 720
Cdd:cd18068 82 KWQeglkDEEKIEVNelaTYKRPQERSYKlqRWQEEGGVMIIGYDMyrilaQERNVKSREKLKEIfnkalvdPGPDF--- 158
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034562578 721 gtstpllriawarIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLR 784
Cdd:cd18068 159 -------------VVCDEGHILKNEASAVSKAMNSIRTKRRIVLTGTPLQNNLIEYHCMVNFVK 209
|
|
| DEXHc_CHD3 |
cd18055 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ... |
570-820 |
1.32e-10 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350813 [Multi-domain] Cd Length: 232 Bit Score: 62.72 E-value: 1.32e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 570 LLLHQKQALAWLLWRESQKPQGgILADDMGLGKTLTMIALILTqknqekkeekekstaltwLSKDDScdfTSHGTLIICP 649
Cdd:cd18055 1 LHMYQLEGLNWLRFSWAQGTDT-ILADEMGLGKTIQTIVFLYS------------------LYKEGH---TKGPFLVSAP 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 650 ASLIHHWKNEVEkrVNSNKLRVYLYHGpNRDSRARVLSTYDIVITTYSLVAKEIPTNKQEAEIpgaNLNVEGTSTPLL-- 727
Cdd:cd18055 59 LSTIINWEREFQ--MWAPDFYVVTYTG-DKDSRAIIRENEFSFDDNAVKGGKKAFKMKREAQV---KFHVLLTSYELVti 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 728 ------RIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPFDEFNLWRSQVDNG 801
Cdd:cd18055 133 dqaalgSIRWACLVVDEAHRLKNNQSKFFRVLNGYKIDHKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADI 212
|
250 260
....*....|....*....|
gi 1034562578 802 SKKGG-ERLSILTKSLLLRR 820
Cdd:cd18055 213 SKEDQiKKLHDLLGPHMLRR 232
|
|
| DEXHc_ARIP4 |
cd18069 |
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ... |
591-784 |
2.20e-10 |
|
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350827 [Multi-domain] Cd Length: 227 Bit Score: 62.14 E-value: 2.20e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 591 GGILADDMGLGKTLTMIALIltqknqekkeekekstaltwlskDDSCDFTSHGT-LIICPASLIHHWKNEVEK------- 662
Cdd:cd18069 30 GCILAHSMGLGKTLQVISFL-----------------------DVLLRHTGAKTvLAIVPVNTLQNWLSEFNKwlpppea 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 663 --RVNSNKLRVYLYHGPNR--DSRARVLSTYD----IVITTYSLVAKEiptnkqeaeiPGANLnvegtstpllriawarI 734
Cdd:cd18069 87 lpNVRPRPFKVFILNDEHKttAARAKVIEDWVkdggVLLMGYEMFRLR----------PGPDV----------------V 140
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1034562578 735 ILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLR 784
Cdd:cd18069 141 ICDEGHRIKNCHASTSQALKNIRSRRRIVLTGYPLQNNLIEYWCMVDFVR 190
|
|
| DEXHc_CHD5 |
cd18057 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ... |
573-820 |
1.46e-09 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350815 [Multi-domain] Cd Length: 232 Bit Score: 59.69 E-value: 1.46e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 573 HQKQALAWLLWRESQKPQGgILADDMGLGKTLTMIALILTqknqekkeekekstaltwLSKDDScdfTSHGTLIICPASL 652
Cdd:cd18057 4 YQLEGLNWLRFSWAQGTDT-ILADEMGLGKTVQTIVFLYS------------------LYKEGH---SKGPYLVSAPLST 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 653 IHHWKNEVEkrVNSNKLRVYLYHGpNRDSRARV----LSTYDIVITTyslvAKEIPTNKQEAEIpgaNLNVEGTSTPLL- 727
Cdd:cd18057 62 IINWEREFE--MWAPDFYVVTYTG-DKESRSVIreneFSFEDNAIRS----GKKVFRMKKEAQI---KFHVLLTSYELIt 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 728 -------RIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPFDEFNLWRSQVDN 800
Cdd:cd18057 132 idqailgSIEWACLVVDEAHRLKNNQSKFFRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFAD 211
|
250 260
....*....|....*....|.
gi 1034562578 801 GSKKGG-ERLSILTKSLLLRR 820
Cdd:cd18057 212 ISKEDQiKKLHDLLGPHMLRR 232
|
|
| DEXHc_CHD1 |
cd18053 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ... |
573-820 |
2.66e-09 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350811 [Multi-domain] Cd Length: 237 Bit Score: 58.91 E-value: 2.66e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 573 HQKQALAWLLwRESQKPQGGILADDMGLGKTLTMIALiltqknqekkeekekstaLTWLskddscdFTSHGT----LIIC 648
Cdd:cd18053 24 YQLNGLNWLA-HSWCKGNSCILADEMGLGKTIQTISF------------------LNYL-------FHEHQLygpfLLVV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 649 PASLIHHWKNEVEKRVNSNKLRVYLYHGPNRD---------SRARVLStYDIVITTYSLVAKEiptnkqeaeipganlnv 719
Cdd:cd18053 78 PLSTLTSWQREIQTWAPQMNAVVYLGDINSRNmirthewmhPQTKRLK-FNILLTTYEILLKD----------------- 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 720 egtSTPLLRIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFLRCSPFDEFNLWRSQVD 799
Cdd:cd18053 140 ---KSFLGGLNWAFIGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFSSWEDFEEEHG 216
|
250 260
....*....|....*....|.
gi 1034562578 800 NGSKKGGERLSILTKSLLLRR 820
Cdd:cd18053 217 KGREYGYASLHKELEPFLLRR 237
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
560-768 |
2.37e-08 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 58.11 E-value: 2.37e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 560 AEDPAGLKVPLLLHQKQALAWLLWRESQKPQGGILADDMGLGKTLTMIALILTQKNQEKkeekekstaltwlskddscdf 639
Cdd:COG1061 71 GDEASGTSFELRPYQQEALEALLAALERGGGRGLVVAPTGTGKTVLALALAAELLRGKR--------------------- 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 640 tshgTLIICP-ASLIHHWKNEVEKrvnsnKLRVYLYHGPNRDsrarvlSTYDIVITTYSLVAKEIPTNKqeaeipganln 718
Cdd:COG1061 130 ----VLVLVPrRELLEQWAEELRR-----FLGDPLAGGGKKD------SDAPITVATYQSLARRAHLDE----------- 183
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1034562578 719 vegtstplLRIAWARIILDEAHNVKNPRVQTSIAvcKLQACARWAVTGTP 768
Cdd:COG1061 184 --------LGDRFGLVIIDEAHHAGAPSYRRILE--AFPAAYRLGLTATP 223
|
|
| DEXHc_CHD4 |
cd18056 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ... |
573-783 |
4.84e-08 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350814 [Multi-domain] Cd Length: 232 Bit Score: 55.07 E-value: 4.84e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 573 HQKQALAWLLWRESQKPQGgILADDMGLGKTLTMIALILTqknqekkeekekstaltwLSKDDScdftSHGTLII-CPAS 651
Cdd:cd18056 4 YQLEGLNWLRFSWAQGTDT-ILADEMGLGKTVQTAVFLYS------------------LYKEGH----SKGPFLVsAPLS 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 652 LIHHWKNEVEkrVNSNKLRVYLYHGpNRDSRARV----LSTYDIVITTyslvAKEIPTNKQEAEIpgaNLNVEGTSTPLL 727
Cdd:cd18056 61 TIINWEREFE--MWAPDMYVVTYVG-DKDSRAIIreneFSFEDNAIRG----GKKASRMKKEASV---KFHVLLTSYELI 130
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034562578 728 --------RIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQNNLLDMYSLLKFL 783
Cdd:cd18056 131 tidmailgSIDWACLIVDEAHRLKNNQSKFFRVLNGYSLQHKLLLTGTPLQNNLEELFHLLNFL 194
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
573-742 |
1.32e-06 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 49.23 E-value: 1.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 573 HQKQALAWLLWRESQKPqgGILADDMGLGKTLTMIALIltqknqekkeekekstaltwlskddsCDFTSHGTLIICP-AS 651
Cdd:cd17926 4 YQEEALEAWLAHKNNRR--GILVLPTGSGKTLTALALI--------------------------AYLKELRTLIVVPtDA 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 652 LIHHWKNEVEKRVNSNKLRvYLYHGPNRDSRARvlstyDIVITTYSLVakeipTNKQEAEIPGANlnvegtstpllriAW 731
Cdd:cd17926 56 LLDQWKERFEDFLGDSSIG-LIGGGKKKDFDDA-----NVVVATYQSL-----SNLAEEEKDLFD-------------QF 111
|
170
....*....|.
gi 1034562578 732 ARIILDEAHNV 742
Cdd:cd17926 112 GLLIVDEAHHL 122
|
|
| zf-GRF |
pfam06839 |
GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding ... |
4-39 |
8.00e-06 |
|
GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding proteins. It seems likely that this domain is involved in nucleic acid binding. It is named GRF after three conserved residues in the centre of the alignment of the domain. This zinc finger may be related to pfam01396.
Pssm-ID: 462017 Cd Length: 45 Bit Score: 43.93 E-value: 8.00e-06
10 20 30
....*....|....*....|....*....|....*....
gi 1034562578 4 VRCPeHGTFCFLKTGVRDGPNKGKSFYVC---RADTCSF 39
Cdd:pfam06839 1 PLCP-CGQRAVLLTVRKTGPNPGRQFYKCpvgREKQCGF 38
|
|
| PTZ00108 |
PTZ00108 |
DNA topoisomerase 2-like protein; Provisional |
147-378 |
1.89e-03 |
|
DNA topoisomerase 2-like protein; Provisional
Pssm-ID: 240271 [Multi-domain] Cd Length: 1388 Bit Score: 42.73 E-value: 1.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 147 EEKKADKKQREKGDQLFDQKK--EQKPEMMEKDLSSGLVPKKKQSVVQEKKQEEGAEIQCEAETGGTHKRDFSEIKSQQC 224
Cdd:PTZ00108 1148 EEKEIAKEQRLKSKTKGKASKlrKPKLKKKEKKKKKSSADKSKKASVVGNSKRVDSDEKRKLDDKPDNKKSNSSGSDQED 1227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 225 QGNELTRPSASSQEKSSGKSQDVQRESEPLREKVTQLL---------PQNVHSHNSISKPQKGGPLNKEYTNW-EAKETK 294
Cdd:PTZ00108 1228 DEEQKTKPKKSSVKRLKSKKNNSSKSSEDNDEFSSDDLskegkpknaPKRVSAVQYSPPPPSKRPDGESNGGSkPSSPTK 1307
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034562578 295 AKDGPSIQATQKSLPQGhfqERPETHSVPAPGGPAAQAAPAAPGLSLGEGREAATSSDDEEEDDVVFVSSKPGSPLLFDS 374
Cdd:PTZ00108 1308 KKVKKRLEGSLAALKKK---KKSEKKTARKKKSKTRVKQASASQSSRLLRRPRKKKSDSSSEDDDDSEVDDSEDEDDEDD 1384
|
....
gi 1034562578 375 TLDL 378
Cdd:PTZ00108 1385 EDDD 1388
|
|
| |
