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Conserved domains on  [gi|1034563125|ref|XP_016858245|]
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SLAM family member 9 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig_SLAM-like_N cd16842
N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule ...
 59-160 8.58e-36

N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family and similar proteins. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. Members of this group include proteins such as CD84, SLAM (CD150), Ly-9 (CD229), NTB-A (ly-108, SLAM6), 19A (CRACC), and SLAMF9. The genes coding for the SLAM family are nested on chromosome 1, in humans at 1q23, and in mice at 1H2. The SLAM family is a subset of the CD2 family, which also includes CD2 and CD58 located on chromosome 1 at 1p13 in humans. In mice, CD2 is located on chromosome 3, and there is no CD58 homolog. The SLAM family proteins are organized as an extracellular domain with either two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


:

Pssm-ID: 409517  Cd Length: 102  Bit Score: 124.74  E-value: 8.58e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563125  59 EVVAVLQESISLPLEIPPDEEVENIIWSSHKSLATVVPGKEGHPaTIMVTNPHYQGQVSFLDPSYSLHISNLSWEDSGLY 138
Cdd:cd16842     2 EVNGILGGSVTFPLNISDGQEIENITWSFKTSLAVIAPGEGGAP-EIIITDKSYKERLNISQNDYSLQISNLTMEDAGSY 80

                          90       100
                  ....*....|....*....|..
gi 1034563125 139 QAQVNLRTSQISTMQQYNICVY 160
Cdd:cd16842    81 RARINTKNSRVTITKEFTLHIY 102
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 2-44 4.39e-07

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd05753:

Pssm-ID: 472250  Cd Length: 83  Bit Score: 46.91  E-value: 4.39e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1034563125   2 RENQTLSMRGATMQSRGQYSCTGQVMYipqtFTQTSETAMVQV 44
Cdd:cd05753    45 YENSNFSIPQATLSDSGSYHCSGTVRI----KRRSSESVNITV 83
 
Name Accession Description Interval E-value
Ig_SLAM-like_N cd16842
N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule ...
 59-160 8.58e-36

N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family and similar proteins. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. Members of this group include proteins such as CD84, SLAM (CD150), Ly-9 (CD229), NTB-A (ly-108, SLAM6), 19A (CRACC), and SLAMF9. The genes coding for the SLAM family are nested on chromosome 1, in humans at 1q23, and in mice at 1H2. The SLAM family is a subset of the CD2 family, which also includes CD2 and CD58 located on chromosome 1 at 1p13 in humans. In mice, CD2 is located on chromosome 3, and there is no CD58 homolog. The SLAM family proteins are organized as an extracellular domain with either two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


Pssm-ID: 409517  Cd Length: 102  Bit Score: 124.74  E-value: 8.58e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563125  59 EVVAVLQESISLPLEIPPDEEVENIIWSSHKSLATVVPGKEGHPaTIMVTNPHYQGQVSFLDPSYSLHISNLSWEDSGLY 138
Cdd:cd16842     2 EVNGILGGSVTFPLNISDGQEIENITWSFKTSLAVIAPGEGGAP-EIIITDKSYKERLNISQNDYSLQISNLTMEDAGSY 80

                          90       100
                  ....*....|....*....|..
gi 1034563125 139 QAQVNLRTSQISTMQQYNICVY 160
Cdd:cd16842    81 RARINTKNSRVTITKEFTLHIY 102
Ig2_FcgammaR_like cd05753
Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; ...
 2-44 4.39e-07

Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs). Interactions between IgG and FcgammaR are important to the initiation of cellular and humoral response. IgG binding to FcgammaR leads to a cascade of signals and ultimately to functions such as antibody-dependent-cellular-cytotoxicity (ADCC), endocytosis, phagocytosis, release of inflammatory mediators, etc. FcgammaR has two Ig-like domains. This group also contains FcepsilonRI which binds IgE with high affinity.


Pssm-ID: 409411  Cd Length: 83  Bit Score: 46.91  E-value: 4.39e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1034563125   2 RENQTLSMRGATMQSRGQYSCTGQVMYipqtFTQTSETAMVQV 44
Cdd:cd05753    45 YENSNFSIPQATLSDSGSYHCSGTVRI----KRRSSESVNITV 83
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 56-143 4.32e-04

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 39.36  E-value: 4.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563125  56 GSEEVVAVLQESISLPLEIPPDEEVEN--IIWSshKSLATVVPGKEGHPATIMVTNPHYQGQVSFLDP----SYSLHISN 129
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTYSSSMSEAStsVYWY--RQPPGKGPTFLIAYYSNGSEEGVKKGRFSGRGDpsngDGSLTIQN 79

                          90
                  ....*....|....
gi 1034563125 130 LSWEDSGLYQAQVN 143
Cdd:pfam07686  80 LTLSDSGTYTCAVI 93
 
Name Accession Description Interval E-value
Ig_SLAM-like_N cd16842
N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule ...
 59-160 8.58e-36

N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family and similar proteins. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. Members of this group include proteins such as CD84, SLAM (CD150), Ly-9 (CD229), NTB-A (ly-108, SLAM6), 19A (CRACC), and SLAMF9. The genes coding for the SLAM family are nested on chromosome 1, in humans at 1q23, and in mice at 1H2. The SLAM family is a subset of the CD2 family, which also includes CD2 and CD58 located on chromosome 1 at 1p13 in humans. In mice, CD2 is located on chromosome 3, and there is no CD58 homolog. The SLAM family proteins are organized as an extracellular domain with either two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


Pssm-ID: 409517  Cd Length: 102  Bit Score: 124.74  E-value: 8.58e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563125  59 EVVAVLQESISLPLEIPPDEEVENIIWSSHKSLATVVPGKEGHPaTIMVTNPHYQGQVSFLDPSYSLHISNLSWEDSGLY 138
Cdd:cd16842     2 EVNGILGGSVTFPLNISDGQEIENITWSFKTSLAVIAPGEGGAP-EIIITDKSYKERLNISQNDYSLQISNLTMEDAGSY 80

                          90       100
                  ....*....|....*....|..
gi 1034563125 139 QAQVNLRTSQISTMQQYNICVY 160
Cdd:cd16842    81 RARINTKNSRVTITKEFTLHIY 102
Ig2_FcgammaR_like cd05753
Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; ...
 2-44 4.39e-07

Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains; The members here are composed of the second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs). Interactions between IgG and FcgammaR are important to the initiation of cellular and humoral response. IgG binding to FcgammaR leads to a cascade of signals and ultimately to functions such as antibody-dependent-cellular-cytotoxicity (ADCC), endocytosis, phagocytosis, release of inflammatory mediators, etc. FcgammaR has two Ig-like domains. This group also contains FcepsilonRI which binds IgE with high affinity.


Pssm-ID: 409411  Cd Length: 83  Bit Score: 46.91  E-value: 4.39e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1034563125   2 RENQTLSMRGATMQSRGQYSCTGQVMYipqtFTQTSETAMVQV 44
Cdd:cd05753    45 YENSNFSIPQATLSDSGSYHCSGTVRI----KRRSSESVNITV 83
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 56-143 4.32e-04

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 39.36  E-value: 4.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563125  56 GSEEVVAVLQESISLPLEIPPDEEVEN--IIWSshKSLATVVPGKEGHPATIMVTNPHYQGQVSFLDP----SYSLHISN 129
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTYSSSMSEAStsVYWY--RQPPGKGPTFLIAYYSNGSEEGVKKGRFSGRGDpsngDGSLTIQN 79

                          90
                  ....*....|....
gi 1034563125 130 LSWEDSGLYQAQVN 143
Cdd:pfam07686  80 LTLSDSGTYTCAVI 93
IgV_1_PVR_like cd05718
First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 ...
 58-138 1.79e-03

First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 and necl-5), and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155 and nectin-like protein 5 (necl-5)). Poliovirus (PV) binds to its cellular receptor (PVR/CD155) to initiate infection. CD155 is a membrane-anchored, single-span glycoprotein; its extracellular region has three Ig-like domains. There are four different isotypes of CD155 (referred to as alpha, beta, gamma, and delta), that result from alternate splicing of the CD155 mRNA, and have identical extracellular domains. CD155-beta and CD155-gamma are secreted; CD155-alpha and CD155-delta are membrane-bound and function as PV receptors. The virus recognition site is contained in the amino-terminal domain, D1. Having the virus attachment site on the receptor distal from the plasma membrane may be important for successful initiation of infection of cells by the virus. CD155 binds in the poliovirus "canyon" with a footprint similar to that of the intercellular adhesion molecule-1 receptor on human rhinoviruses. This group also includes the first Ig-like domain of nectin-1 (also known as poliovirus receptor related protein(PVRL)1; CD111), nectin-3 (also known as PVRL 3), nectin-4 (also known as PVRL4; LNIR receptor)and DNAX accessory molecule 1 (DNAM-1; CD226).


Pssm-ID: 409383  Cd Length: 113  Bit Score: 37.43  E-value: 1.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563125  58 EEVVAVLQESISLPLEIPP--DEEVENIIW-----SSHKSLATVvpgkegHPATIMVTNPHYQGQVSFLDPSY-----SL 125
Cdd:cd05718     7 TEVTGFLGGSVTLPCSLTSpgTTKITQVTWmkigaGSSQNVAVF------HPQYGPSVPNPYAERVEFLAARLglrnaTL 80

                          90
                  ....*....|...
gi 1034563125 126 HISNLSWEDSGLY 138
Cdd:cd05718    81 RIRNLRVEDEGNY 93
IgV_CD2_like_N cd05775
N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; ...
 57-139 4.82e-03

N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain (or domain 1) of T-cell surface antigen Clusters of Differentiation (CD) 2 and similar proteins. CD2 is a T-cell specific surface glycoprotein and is critically important for mediating adhesion between T cells and antigen-presenting cells or between cytolytic T cells and target cells. CD2 is located on chromosome 1 at 1p13 in humans and on chromosome 3 in mice. CD2 contains an extracellular domain with two or Ig-like domains, a single transmembrane segment, and a cytoplasmic region rich in proline and basic residues.


Pssm-ID: 409431  Cd Length: 98  Bit Score: 35.79  E-value: 4.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034563125  57 SEEVVAVLQESISLPLEIPPDEEVEnIIWSSHKSL-ATVVPGKEghpatIMVTNPhYQGQVSFLDPSYSLHISNLSWEDS 135
Cdd:cd05775     2 SGEVYGALGGNVTLTISSLQDDIDE-IKWKKTKDKiVEWENNIG-----PTYFGS-FKDRVLLDKESGSLTIKNLTKEDS 74


                  ....
gi 1034563125 136 GLYQ 139
Cdd:cd05775    75 GTYE 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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