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Conserved domains on  [gi|1034614936|ref|XP_016859910|]
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tRNA endonuclease ANKZF1 isoform X5 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
bVLRF1 pfam18826
Bacteroidetes VLRF1 release factor; Archaeo-eukaryotic release factor domain family belonging ...
 207-351 1.11e-70

Bacteroidetes VLRF1 release factor; Archaeo-eukaryotic release factor domain family belonging to the VLRF1 clade observed primarily in the bacteroidetes bacterial lineage. Contains a conserved glutamine residue in the release factor catalytic loop, suggesting it functions as an active peptidyl-tRNA hydrolase at the ribosome.


:

Pssm-ID: 465880  Cd Length: 143  Bit Score: 223.92  E-value: 1.11e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034614936 207 CVVLMAAAGHFAGAIFQGREVVTHKTFHRYTVRAKRGTAQGLRDARGGPSHSAGANLRRYNEATLYKDVRDLLAgpSWAK 286
Cdd:pfam18826   1 WALLMIGGGHFAGAVFSGGEVLAHKTFHRYTTRRKQGGSQSSNDNAKGKAKSAGASLRRYNEQALQEDIRELLS--EWKE 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034614936 287 ALEEAGTILLRAPRSGRSLFFGGKGAPLQRGDPRLWDIPLATRRPTFQELQRVLHKLTTLHVYEE 351
Cdd:pfam18826  79 DIDKCELIFIRAPGSNRKILFGYEGAPLDKDDPRLRSIPFPTRRPTFSELKRVFSELTTVKVSHK 143
ANKYR super family cl34000
Ankyrin repeat [Signal transduction mechanisms];
495-570 6.08e-08

Ankyrin repeat [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG0666:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 54.57  E-value: 6.08e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034614936 495 WNALLAACRAGDVGVLKLQLApSPADPRVLSllsaplgSGGFTLLHAAAAAGRGSVVRLLLEAGA-RTIDTRNGGTA 570
Cdd:COG0666   154 NTPLHLAAANGNLEIVKLLLE-AGADVNARD-------NDGETPLHLAAENGHLEIVKLLLEAGAdVNAKDNDGKTA 222
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 69-103 2.60e-03

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


:

Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 35.69  E-value: 2.60e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1034614936   69 SEKLFCSTCDQTFQNHQEQREHYKLDWHRFNLKQR 103
Cdd:smart00451   1 TGGFYCKLCNVTFTDEISVEAHLKGKKHKKNVKKR 35
 
Name Accession Description Interval E-value
bVLRF1 pfam18826
Bacteroidetes VLRF1 release factor; Archaeo-eukaryotic release factor domain family belonging ...
 207-351 1.11e-70

Bacteroidetes VLRF1 release factor; Archaeo-eukaryotic release factor domain family belonging to the VLRF1 clade observed primarily in the bacteroidetes bacterial lineage. Contains a conserved glutamine residue in the release factor catalytic loop, suggesting it functions as an active peptidyl-tRNA hydrolase at the ribosome.


Pssm-ID: 465880  Cd Length: 143  Bit Score: 223.92  E-value: 1.11e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034614936 207 CVVLMAAAGHFAGAIFQGREVVTHKTFHRYTVRAKRGTAQGLRDARGGPSHSAGANLRRYNEATLYKDVRDLLAgpSWAK 286
Cdd:pfam18826   1 WALLMIGGGHFAGAVFSGGEVLAHKTFHRYTTRRKQGGSQSSNDNAKGKAKSAGASLRRYNEQALQEDIRELLS--EWKE 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034614936 287 ALEEAGTILLRAPRSGRSLFFGGKGAPLQRGDPRLWDIPLATRRPTFQELQRVLHKLTTLHVYEE 351
Cdd:pfam18826  79 DIDKCELIFIRAPGSNRKILFGYEGAPLDKDDPRLRSIPFPTRRPTFSELKRVFSELTTVKVSHK 143
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
495-570 6.08e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 54.57  E-value: 6.08e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034614936 495 WNALLAACRAGDVGVLKLQLApSPADPRVLSllsaplgSGGFTLLHAAAAAGRGSVVRLLLEAGA-RTIDTRNGGTA 570
Cdd:COG0666   154 NTPLHLAAANGNLEIVKLLLE-AGADVNARD-------NDGETPLHLAAENGHLEIVKLLLEAGAdVNAKDNDGKTA 222
Ank_2 pfam12796
Ankyrin repeats (3 copies);
498-570 8.59e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 41.64  E-value: 8.59e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034614936 498 LLAACRAGDVGVLKLqLAPSPADPRVLSLLsaplgsgGFTLLHAAAAAGRGSVVRLLLEAGARTIDTrNGGTA 570
Cdd:pfam12796   1 LHLAAKNGNLELVKL-LLENGADANLQDKN-------GRTALHLAAKNGHLEIVKLLLEHADVNLKD-NGRTA 64
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 69-103 2.60e-03

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 35.69  E-value: 2.60e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1034614936   69 SEKLFCSTCDQTFQNHQEQREHYKLDWHRFNLKQR 103
Cdd:smart00451   1 TGGFYCKLCNVTFTDEISVEAHLKGKKHKKNVKKR 35
 
Name Accession Description Interval E-value
bVLRF1 pfam18826
Bacteroidetes VLRF1 release factor; Archaeo-eukaryotic release factor domain family belonging ...
 207-351 1.11e-70

Bacteroidetes VLRF1 release factor; Archaeo-eukaryotic release factor domain family belonging to the VLRF1 clade observed primarily in the bacteroidetes bacterial lineage. Contains a conserved glutamine residue in the release factor catalytic loop, suggesting it functions as an active peptidyl-tRNA hydrolase at the ribosome.


Pssm-ID: 465880  Cd Length: 143  Bit Score: 223.92  E-value: 1.11e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034614936 207 CVVLMAAAGHFAGAIFQGREVVTHKTFHRYTVRAKRGTAQGLRDARGGPSHSAGANLRRYNEATLYKDVRDLLAgpSWAK 286
Cdd:pfam18826   1 WALLMIGGGHFAGAVFSGGEVLAHKTFHRYTTRRKQGGSQSSNDNAKGKAKSAGASLRRYNEQALQEDIRELLS--EWKE 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034614936 287 ALEEAGTILLRAPRSGRSLFFGGKGAPLQRGDPRLWDIPLATRRPTFQELQRVLHKLTTLHVYEE 351
Cdd:pfam18826  79 DIDKCELIFIRAPGSNRKILFGYEGAPLDKDDPRLRSIPFPTRRPTFSELKRVFSELTTVKVSHK 143
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
495-570 6.08e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 54.57  E-value: 6.08e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034614936 495 WNALLAACRAGDVGVLKLQLApSPADPRVLSllsaplgSGGFTLLHAAAAAGRGSVVRLLLEAGA-RTIDTRNGGTA 570
Cdd:COG0666   154 NTPLHLAAANGNLEIVKLLLE-AGADVNARD-------NDGETPLHLAAENGHLEIVKLLLEAGAdVNAKDNDGKTA 222
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
495-570 3.94e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 51.88  E-value: 3.94e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034614936 495 WNALLAACRAGDVGVLKLQLApSPADPRVLsllsaplGSGGFTLLHAAAAAGRGSVVRLLLEAGARtIDTRN--GGTA 570
Cdd:COG0666   121 ETPLHLAAYNGNLEIVKLLLE-AGADVNAQ-------DNDGNTPLHLAAANGNLEIVKLLLEAGAD-VNARDndGETP 189
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
493-570 1.20e-06

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 50.72  E-value: 1.20e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034614936 493 ELWNALLAACRAGDVGVLKLQLApSPADPRVLSllsaplgSGGFTLLHAAAAAGRGSVVRLLLEAGARtIDTRN--GGTA 570
Cdd:COG0666    86 GGNTLLHAAARNGDLEIVKLLLE-AGADVNARD-------KDGETPLHLAAYNGNLEIVKLLLEAGAD-VNAQDndGNTP 156
Ank_2 pfam12796
Ankyrin repeats (3 copies);
498-570 8.59e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 41.64  E-value: 8.59e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034614936 498 LLAACRAGDVGVLKLqLAPSPADPRVLSLLsaplgsgGFTLLHAAAAAGRGSVVRLLLEAGARTIDTrNGGTA 570
Cdd:pfam12796   1 LHLAAKNGNLELVKL-LLENGADANLQDKN-------GRTALHLAAKNGHLEIVKLLLEHADVNLKD-NGRTA 64
Ank_2 pfam12796
Ankyrin repeats (3 copies);
495-566 1.03e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 41.25  E-value: 1.03e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034614936 495 WNALLAACRAGDVGVLKLqlapspadprVLSLLSAPLGSGGFTLLHAAAAAGRGSVVRLLLEAGARtIDTRN 566
Cdd:pfam12796  31 RTALHLAAKNGHLEIVKL----------LLEHADVNLKDNGRTALHYAARSGHLEIVKLLLEKGAD-INVKD 91
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 69-103 2.60e-03

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 35.69  E-value: 2.60e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1034614936   69 SEKLFCSTCDQTFQNHQEQREHYKLDWHRFNLKQR 103
Cdd:smart00451   1 TGGFYCKLCNVTFTDEISVEAHLKGKKHKKNVKKR 35
Ank_4 pfam13637
Ankyrin repeats (many copies);
495-555 2.90e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.10  E-value: 2.90e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034614936 495 WNALLAACRAGDVGVLKLqLAPSPADPRVLSllsaplgSGGFTLLHAAAAAGRGSVVRLLL 555
Cdd:pfam13637   2 LTALHAAAASGHLELLRL-LLEKGADINAVD-------GNGETALHFAASNGNVEVLKLLL 54
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
474-570 3.39e-03

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 39.94  E-value: 3.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034614936 474 AVAAPLGPLLDEAKAPGQPELWNALLAACRAGDVGVLKLQLAPSPADprvlsllsAPLGSGGFTLLHAAAAAGRGSVVRL 553
Cdd:COG0666    34 LLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI--------NAKDDGGNTLLHAAARNGDLEIVKL 105

                          90
                  ....*....|....*....
gi 1034614936 554 LLEAGArTIDTRN--GGTA 570
Cdd:COG0666   106 LLEAGA-DVNARDkdGETP 123
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 535-559 3.51e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 35.34  E-value: 3.51e-03
                          10        20
                  ....*....|....*....|....*.
gi 1034614936 535 GFTLLHAAAA-AGRGSVVRLLLEAGA 559
Cdd:pfam00023   2 GNTPLHLAAGrRGNLEIVKLLLSKGA 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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